ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gas transport (GO:0015669)	9.21040330
2	regulation of DNA methylation (GO:0044030)	7.71686994
3	regulation of female gonad development (GO:2000194)	7.19148029
4	piRNA metabolic process (GO:0034587)	6.99374580
5	synapsis (GO:0007129)	6.76463503
6	regulation of acrosome reaction (GO:0060046)	6.69949912
7	male meiosis I (GO:0007141)	6.47632114
8	meiotic cell cycle (GO:0051321)	6.05917444
9	DNA methylation involved in gamete generation (GO:0043046)	5.73460013
10	chromosome organization involved in meiosis (GO:0070192)	5.62040991
11	meiosis I (GO:0007127)	5.53611167
12	regulation of meiosis I (GO:0060631)	5.46269354
13	regulation of histone H3-K9 methylation (GO:0051570)	5.35388224
14	synaptonemal complex assembly (GO:0007130)	5.32226382
15	homocysteine metabolic process (GO:0050667)	5.20859746
16	multicellular organism reproduction (GO:0032504)	5.02676891
17	meiotic nuclear division (GO:0007126)	4.98213839
18	negative regulation of reproductive process (GO:2000242)	4.97913173
19	male meiosis (GO:0007140)	4.77180290
20	regulation of mitotic spindle organization (GO:0060236)	4.71054383
21	mitotic chromosome condensation (GO:0007076)	4.67857930
22	synaptonemal complex organization (GO:0070193)	4.67718401
23	female gamete generation (GO:0007292)	4.59956956
24	glycine transport (GO:0015816)	4.52240858
25	oocyte development (GO:0048599)	4.49189472
26	protein localization to chromosome (GO:0034502)	4.48051208
27	protein localization to chromosome, centromeric region (GO:0071459)	4.44546314
28	gene silencing by RNA (GO:0031047)	4.39548871
29	regulation of spindle organization (GO:0090224)	4.36412852
30	protoporphyrinogen IX metabolic process (GO:0046501)	4.19376130
31	meiotic cell cycle process (GO:1903046)	4.15735901
32	protein kinase C signaling (GO:0070528)	4.10842952
33	positive regulation of histone H3-K4 methylation (GO:0051571)	4.04827802
34	protoporphyrinogen IX biosynthetic process (GO:0006782)	3.99239813
35	negative regulation of histone methylation (GO:0031061)	3.95992638
36	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.94739511
37	positive regulation of humoral immune response (GO:0002922)	3.88328043
38	binding of sperm to zona pellucida (GO:0007339)	3.76352806
39	primitive streak formation (GO:0090009)	3.69599618
40	protein localization to kinetochore (GO:0034501)	3.67367226
41	CENP-A containing nucleosome assembly (GO:0034080)	3.67156583
42	histone H3-K9 demethylation (GO:0033169)	3.59458279
43	regulation of histone H3-K4 methylation (GO:0051569)	3.55365433
44	regulation of steroid hormone secretion (GO:2000831)	3.54538607
45	mitotic metaphase plate congression (GO:0007080)	3.52881377
46	regulation of spindle checkpoint (GO:0090231)	3.50796619
47	sister chromatid cohesion (GO:0007062)	3.50446013
48	reproduction (GO:0000003)	3.48168576
49	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.40942947
50	histone exchange (GO:0043486)	3.40114245
51	erythrocyte development (GO:0048821)	3.33080128
52	S-adenosylmethionine metabolic process (GO:0046500)	3.30300194
53	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.27445342
54	attachment of spindle microtubules to kinetochore (GO:0008608)	3.25386255
55	positive regulation of histone methylation (GO:0031062)	3.25198356
56	phosphorelay signal transduction system (GO:0000160)	3.24785430
57	regulation of histone methylation (GO:0031060)	3.24785205
58	chromatin remodeling at centromere (GO:0031055)	3.24121675
59	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.23236271
60	proteasome assembly (GO:0043248)	3.20985484
61	histone phosphorylation (GO:0016572)	3.17609011
62	erythrocyte maturation (GO:0043249)	3.15606198
63	retinal cone cell development (GO:0046549)	3.11432213
64	DNA replication checkpoint (GO:0000076)	3.10821775
65	DNA replication-independent nucleosome organization (GO:0034724)	3.08382338
66	DNA replication-independent nucleosome assembly (GO:0006336)	3.08382338
67	DNA synthesis involved in DNA repair (GO:0000731)	3.06832895
68	nuclear pore organization (GO:0006999)	3.01030748
69	regulation of meiosis (GO:0040020)	2.99622325
70	fertilization (GO:0009566)	2.99558085
71	viral transcription (GO:0019083)	2.98404491
72	positive regulation of reproductive process (GO:2000243)	2.93506034
73	gene silencing (GO:0016458)	2.92028424
74	regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)	2.91218478
75	N-terminal protein amino acid acetylation (GO:0006474)	2.89919646
76	positive regulation of chromosome segregation (GO:0051984)	2.88844278
77	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	2.86257916
78	translational termination (GO:0006415)	2.85119116
79	positive regulation of gastrulation (GO:2000543)	2.83938282
80	regulation of meiotic cell cycle (GO:0051445)	2.83374996
81	chromosome segregation (GO:0007059)	2.80598472
82	metaphase plate congression (GO:0051310)	2.80541112
83	sperm-egg recognition (GO:0035036)	2.80216693
84	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.79586537
85	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.79586537
86	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.79586537
87	maturation of SSU-rRNA (GO:0030490)	2.78106122
88	DNA damage induced protein phosphorylation (GO:0006975)	2.77691708
89	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.76016199
90	regulation of response to osmotic stress (GO:0047484)	2.74533323
91	establishment of chromosome localization (GO:0051303)	2.72808987
92	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.72794258
93	centriole replication (GO:0007099)	2.71829561
94	regulation of reproductive process (GO:2000241)	2.71288272
95	nuclear pore complex assembly (GO:0051292)	2.70044074
96	regulation of nucleobase-containing compound transport (GO:0032239)	2.69925010
97	chromatin assembly or disassembly (GO:0006333)	2.67384156
98	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	15.6795693
99	regulation of retinoic acid receptor signaling pathway (GO:0048385)	13.1265401
100	oxygen transport (GO:0015671)	10.3445081

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	9.99703405
2	E2F7_22180533_ChIP-Seq_HELA_Human	6.27498813
3	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	5.07695009
4	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	5.07695009
5	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	5.07695009
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.44591082
7	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.29597506
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.03068977
9	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.96742116
10	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.89031379
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.68921495
12	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.68487322
13	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.35661992
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.24816344
15	GATA1_19941826_ChIP-Seq_K562_Human	2.10034802
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.06714978
17	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.96550760
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.95998310
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.91120984
20	VDR_22108803_ChIP-Seq_LS180_Human	1.90460607
21	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.82734670
22	NCOR1_26117541_ChIP-Seq_K562_Human	1.82717567
23	AR_21909140_ChIP-Seq_LNCAP_Human	1.80143857
24	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.64841540
25	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.61012592
26	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.60376884
27	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.58767569
28	RBPJ_21746931_ChIP-Seq_IB4_Human	1.57895600
29	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.56256916
30	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.53376146
31	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.53369464
32	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.52704481
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.49400252
34	NFYB_21822215_ChIP-Seq_K562_Human	1.45296962
35	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.44830802
36	PHF8_20622853_ChIP-Seq_HELA_Human	1.43691995
37	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.41601369
38	ETV1_20927104_ChIP-Seq_GIST48_Human	1.41596346
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39653749
40	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.38686460
41	GATA2_19941826_ChIP-Seq_K562_Human	1.37936446
42	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.37887205
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.37713378
44	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.34457316
45	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.34412171
46	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.33925126
47	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.33830484
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.32170214
49	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.31970963
50	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.30468193
51	HTT_18923047_ChIP-ChIP_STHdh_Human	1.28885177
52	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.27172316
53	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.22913358
54	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.22794005
55	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.20291716
56	TBL1_22424771_ChIP-Seq_293T_Human	1.19494181
57	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.17244005
58	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.14323056
59	VDR_23849224_ChIP-Seq_CD4+_Human	1.12074360
60	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.10826913
61	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.10573019
62	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10551895
63	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.10358068
64	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08761439
65	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.07809833
66	IRF1_19129219_ChIP-ChIP_H3396_Human	1.07778316
67	CTCF_21964334_Chip-Seq_Bcells_Human	1.07444597
68	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.05317163
69	NFYA_21822215_ChIP-Seq_K562_Human	1.03793699
70	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.03542708
71	XRN2_22483619_ChIP-Seq_HELA_Human	1.01815202
72	TTF2_22483619_ChIP-Seq_HELA_Human	1.01260317
73	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.99044755
74	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.98966715
75	TP53_22573176_ChIP-Seq_HFKS_Human	0.97712706
76	GABP_19822575_ChIP-Seq_HepG2_Human	0.97296365
77	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.93754389
78	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.93159746
79	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.89872680
80	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.88319064
81	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	0.88231512
82	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.87108469
83	KDM5A_27292631_Chip-Seq_BREAST_Human	0.85179618
84	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.81487785
85	DCP1A_22483619_ChIP-Seq_HELA_Human	0.80568783
86	BCOR_27268052_Chip-Seq_Bcells_Human	0.80400855
87	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.78364153
88	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.74061166
89	CHD1_26751641_Chip-Seq_LNCaP_Human	0.73797044
90	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.72995399
91	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.72391529
92	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.72160441
93	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.72011905
94	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.70085994
95	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.69996867
96	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.69561747
97	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.69537013
98	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.69206243
99	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.69185557
100	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.68847790

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	6.79032357
2	MP0000015_abnormal_ear_pigmentation	4.02572654
3	MP0008877_abnormal_DNA_methylation	3.80963023
4	MP0006292_abnormal_olfactory_placode	3.53977931
5	MP0004147_increased_porphyrin_level	3.53282350
6	MP0003879_abnormal_hair_cell	3.13770290
7	MP0008058_abnormal_DNA_repair	3.02457259
8	MP0003693_abnormal_embryo_hatching	3.01706560
9	MP0002139_abnormal_hepatobiliary_system	2.71429380
10	MP0008789_abnormal_olfactory_epithelium	2.67258133
11	MP0003656_abnormal_erythrocyte_physiolo	2.66804482
12	MP0002210_abnormal_sex_determination	2.64581066
13	MP0005395_other_phenotype	2.55512862
14	MP0003878_abnormal_ear_physiology	2.47580908
15	MP0005377_hearing/vestibular/ear_phenot	2.47580908
16	MP0001929_abnormal_gametogenesis	2.47167511
17	MP0003111_abnormal_nucleus_morphology	2.44461692
18	MP0005499_abnormal_olfactory_system	2.35836983
19	MP0005394_taste/olfaction_phenotype	2.35836983
20	MP0003699_abnormal_female_reproductive	2.26480888
21	MP0010307_abnormal_tumor_latency	2.19650316
22	MP0003077_abnormal_cell_cycle	2.13988495
23	MP0005397_hematopoietic_system_phenotyp	2.11751650
24	MP0001545_abnormal_hematopoietic_system	2.11751650
25	MP0005410_abnormal_fertilization	1.89345592
26	MP0005646_abnormal_pituitary_gland	1.88811605
27	MP0010094_abnormal_chromosome_stability	1.86563606
28	MP0002095_abnormal_skin_pigmentation	1.82137390
29	MP0000653_abnormal_sex_gland	1.81991955
30	MP0008057_abnormal_DNA_replication	1.76440767
31	MP0008932_abnormal_embryonic_tissue	1.76270863
32	MP0008995_early_reproductive_senescence	1.73711123
33	MP0001986_abnormal_taste_sensitivity	1.65092554
34	MP0002161_abnormal_fertility/fecundity	1.64265588
35	MP0003698_abnormal_male_reproductive	1.60844898
36	MP0004957_abnormal_blastocyst_morpholog	1.59809914
37	MP0005076_abnormal_cell_differentiation	1.52726418
38	MP0001145_abnormal_male_reproductive	1.52206450
39	MP0000678_abnormal_parathyroid_gland	1.51180163
40	MP0003136_yellow_coat_color	1.47982730
41	MP0002160_abnormal_reproductive_system	1.46111750
42	MP0005360_urolithiasis	1.40743741
43	MP0009379_abnormal_foot_pigmentation	1.39531437
44	MP0010030_abnormal_orbit_morphology	1.38584285
45	MP0001730_embryonic_growth_arrest	1.35672857
46	MP0001119_abnormal_female_reproductive	1.34413968
47	MP0003890_abnormal_embryonic-extraembry	1.32713033
48	MP0005389_reproductive_system_phenotype	1.32128621
49	MP0001881_abnormal_mammary_gland	1.27209429
50	MP0003950_abnormal_plasma_membrane	1.23703607
51	MP0005647_abnormal_sex_gland	1.23652561
52	MP0002138_abnormal_hepatobiliary_system	1.21734883
53	MP0001324_abnormal_eye_pigmentation	1.14421533
54	MP0009278_abnormal_bone_marrow	1.13610842
55	MP0004233_abnormal_muscle_weight	1.11567294
56	MP0004142_abnormal_muscle_tone	1.11414669
57	MP0002234_abnormal_pharynx_morphology	1.10909467
58	MP0003646_muscle_fatigue	1.08950331
59	MP0001672_abnormal_embryogenesis/_devel	1.08553969
60	MP0005380_embryogenesis_phenotype	1.08553969
61	MP0003186_abnormal_redox_activity	1.05914343
62	MP0000350_abnormal_cell_proliferation	1.04669981
63	MP0001664_abnormal_digestion	1.04332231
64	MP0000631_abnormal_neuroendocrine_gland	0.99877543
65	MP0005083_abnormal_biliary_tract	0.93438635
66	MP0003183_abnormal_peptide_metabolism	0.93180763
67	MP0001919_abnormal_reproductive_system	0.92059396
68	MP0010234_abnormal_vibrissa_follicle	0.89973527
69	MP0003303_peritoneal_inflammation	0.86752043
70	MP0004885_abnormal_endolymph	0.83270454
71	MP0000313_abnormal_cell_death	0.82617199
72	MP0005075_abnormal_melanosome_morpholog	0.81602529
73	MP0005501_abnormal_skin_physiology	0.80088822
74	MP0001764_abnormal_homeostasis	0.79497905
75	MP0005636_abnormal_mineral_homeostasis	0.79459903
76	MP0006276_abnormal_autonomic_nervous	0.77608774
77	MP0002132_abnormal_respiratory_system	0.76708982
78	MP0003984_embryonic_growth_retardation	0.76188900
79	MP0001697_abnormal_embryo_size	0.74177704
80	MP0001502_abnormal_circadian_rhythm	0.71725620
81	MP0002088_abnormal_embryonic_growth/wei	0.71724327
82	MP0001293_anophthalmia	0.70120292
83	MP0002269_muscular_atrophy	0.69943277
84	MP0009840_abnormal_foam_cell	0.68464466
85	MP0003941_abnormal_skin_development	0.67879914
86	MP0003786_premature_aging	0.65028510
87	MP0002084_abnormal_developmental_patter	0.64800347
88	MP0002177_abnormal_outer_ear	0.64175540
89	MP0000372_irregular_coat_pigmentation	0.60917317
90	MP0005409_darkened_coat_color	0.59097256
91	MP0004381_abnormal_hair_follicle	0.58559748
92	MP0006054_spinal_hemorrhage	0.55368488
93	MP0006036_abnormal_mitochondrial_physio	0.55250026
94	MP0002796_impaired_skin_barrier	0.53265857
95	MP0003959_abnormal_lean_body	0.52891623
96	MP0000371_diluted_coat_color	0.51630035
97	MP0003119_abnormal_digestive_system	0.51253231
98	MP0002080_prenatal_lethality	0.51162929
99	MP0002085_abnormal_embryonic_tissue	0.48633666
100	MP0008004_abnormal_stomach_pH	0.46499600

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal hemoglobin (HP:0011902)	9.99198945
2	Abnormality of the heme biosynthetic pathway (HP:0010472)	9.41464826
3	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	5.60010024
4	Pallor (HP:0000980)	4.70625810
5	Abnormality of homocysteine metabolism (HP:0010919)	4.66007372
6	Homocystinuria (HP:0002156)	4.66007372
7	Albinism (HP:0001022)	4.60445467
8	Reticulocytosis (HP:0001923)	4.19994105
9	Male infertility (HP:0003251)	4.09525761
10	Cholecystitis (HP:0001082)	3.75960212
11	Abnormal gallbladder physiology (HP:0012438)	3.75960212
12	Abnormality of the fovea (HP:0000493)	3.54706626
13	Abnormality of reticulocytes (HP:0004312)	3.51470249
14	Osteomalacia (HP:0002749)	3.48343782
15	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.47290600
16	Abnormality of the anterior horn cell (HP:0006802)	3.45053293
17	Degeneration of anterior horn cells (HP:0002398)	3.45053293
18	Rectal prolapse (HP:0002035)	3.42108877
19	Abdominal situs inversus (HP:0003363)	3.37594478
20	Abnormality of abdominal situs (HP:0011620)	3.37594478
21	Supernumerary spleens (HP:0009799)	3.30354607
22	Anterior segment dysgenesis (HP:0007700)	3.24325567
23	Microcytic anemia (HP:0001935)	3.12396136
24	Central scotoma (HP:0000603)	2.94598836
25	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.91179683
26	Gastrointestinal infarctions (HP:0005244)	2.87770216
27	Esophageal neoplasm (HP:0100751)	2.81202644
28	Neoplasm of head and neck (HP:0012288)	2.81202644
29	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.79622434
30	Hypoplasia of the fovea (HP:0007750)	2.79622434
31	Abnormality of DNA repair (HP:0003254)	2.77873109
32	Polycythemia (HP:0001901)	2.71810632
33	Azoospermia (HP:0000027)	2.71691325
34	Premature ovarian failure (HP:0008209)	2.69116945
35	Abnormal platelet function (HP:0011869)	2.65606263
36	Impaired platelet aggregation (HP:0003540)	2.65606263
37	Infertility (HP:0000789)	2.65155566
38	Birth length less than 3rd percentile (HP:0003561)	2.60439336
39	Facial hemangioma (HP:0000329)	2.59380763
40	Gonadotropin excess (HP:0000837)	2.55070506
41	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.53940048
42	Abnormality of the labia minora (HP:0012880)	2.48751743
43	Generalized aminoaciduria (HP:0002909)	2.42871795
44	Chromsome breakage (HP:0040012)	2.42379220
45	Malnutrition (HP:0004395)	2.42220383
46	Spontaneous abortion (HP:0005268)	2.42189284
47	Truncus arteriosus (HP:0001660)	2.42073786
48	Acute necrotizing encephalopathy (HP:0006965)	2.39672408
49	Abnormal lung lobation (HP:0002101)	2.36961444
50	Oligodactyly (hands) (HP:0001180)	2.36224636
51	Ocular albinism (HP:0001107)	2.35316606
52	Hypokinesia (HP:0002375)	2.30964522
53	Absent septum pellucidum (HP:0001331)	2.29666818
54	Congenital ichthyosiform erythroderma (HP:0007431)	2.29184337
55	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.25334332
56	Hypophosphatemic rickets (HP:0004912)	2.23001404
57	Abnormal mitochondria in muscle tissue (HP:0008316)	2.20656597
58	Lip pit (HP:0100267)	2.17634637
59	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.17125327
60	Abnormality of macular pigmentation (HP:0008002)	2.14771091
61	Acute encephalopathy (HP:0006846)	2.14277857
62	Papillary thyroid carcinoma (HP:0002895)	2.13266542
63	Poikilocytosis (HP:0004447)	2.13142400
64	Cholelithiasis (HP:0001081)	2.09439073
65	Bowel incontinence (HP:0002607)	2.08398889
66	Reticulocytopenia (HP:0001896)	2.06808777
67	Abnormality of nail color (HP:0100643)	2.04687993
68	Abnormality of cells of the erythroid lineage (HP:0012130)	2.04335226
69	Biliary tract neoplasm (HP:0100574)	2.01911653
70	Aplasia/Hypoplasia of the macula (HP:0008059)	2.01833540
71	Small intestinal stenosis (HP:0012848)	2.00208813
72	Duodenal stenosis (HP:0100867)	2.00208813
73	Abnormal large intestine physiology (HP:0012700)	1.99040091
74	Septo-optic dysplasia (HP:0100842)	1.98190545
75	Acanthocytosis (HP:0001927)	1.96989951
76	Anencephaly (HP:0002323)	1.94219480
77	Abnormality of the septum pellucidum (HP:0007375)	1.93921557
78	Progressive macrocephaly (HP:0004481)	1.93473277
79	Macrocytic anemia (HP:0001972)	1.92410139
80	Abnormal spermatogenesis (HP:0008669)	1.90820017
81	Hyperthyroidism (HP:0000836)	1.90540300
82	Nausea (HP:0002018)	1.90193002
83	Iris hypopigmentation (HP:0007730)	1.87546372
84	Subcapsular cataract (HP:0000523)	1.87464364
85	Generalized hypopigmentation (HP:0007513)	1.86626258
86	Capillary hemangiomas (HP:0005306)	1.85086945
87	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.84732345
88	Atelectasis (HP:0100750)	1.81254283
89	Impulsivity (HP:0100710)	1.80879166
90	Abnormal gallbladder morphology (HP:0012437)	1.79458207
91	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.78102078
92	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.78102078
93	Proximal tubulopathy (HP:0000114)	1.74054164
94	Microretrognathia (HP:0000308)	1.72079693
95	Wrist flexion contracture (HP:0001239)	1.71501529
96	Abnormal number of erythroid precursors (HP:0012131)	1.71344873
97	Gonadal dysgenesis (HP:0000133)	1.70302876
98	Hypoplasia of the uterus (HP:0000013)	1.69928622
99	Abnormality of the fingertips (HP:0001211)	1.69639887
100	Dysmetric saccades (HP:0000641)	1.65453954

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	4.07744487
2	KSR2	3.87923157
3	MAP3K9	3.29668958
4	TTK	3.22303512
5	MAP3K13	3.03279284
6	ARAF	3.01707637
7	PDK2	2.75060917
8	TRPM7	2.72246235
9	TAOK3	2.67042659
10	RIPK1	2.63247614
11	BMPR2	2.58661403
12	RAF1	2.55569280
13	NEK6	2.37695519
14	MET	2.18013170
15	RIPK4	1.98961859
16	BRAF	1.91589112
17	DMPK	1.84586071
18	STK24	1.80903434
19	BUB1	1.80148435
20	CDC7	1.71813197
21	NTRK3	1.69682009
22	KSR1	1.68949890
23	AURKA	1.45367565
24	CHEK2	1.42509925
25	MELK	1.42047580
26	PLK1	1.38493244
27	MAP3K5	1.35360538
28	CLK1	1.35047029
29	STK3	1.29504188
30	MOS	1.25323511
31	PRKCI	1.23736958
32	MAP3K8	1.21108883
33	BRSK1	1.20973005
34	MAP3K2	1.19977177
35	CDK9	1.19527316
36	NEK2	1.18323353
37	BRSK2	1.14667332
38	EIF2AK3	1.14347209
39	RET	1.09671695
40	CDK19	1.09061936
41	SRPK1	1.06545148
42	CDK12	1.00739408
43	ABL2	0.98333772
44	NME2	0.97888357
45	PKN1	0.97738238
46	MAP2K1	0.97181296
47	CDK7	0.96577640
48	DYRK3	0.96576700
49	JAK3	0.95894983
50	LRRK2	0.93764652
51	CHEK1	0.93344616
52	RPS6KB1	0.92794629
53	TESK2	0.87694310
54	CCNB1	0.87355161
55	TSSK6	0.86586420
56	PIM1	0.86463492
57	PLK4	0.86395778
58	TRIM28	0.80312555
59	ATM	0.75049854
60	PLK3	0.74136577
61	MARK3	0.71596507
62	CDK2	0.69252447
63	PTK2	0.69062197
64	AURKB	0.68380534
65	EEF2K	0.68059146
66	WNK1	0.65464543
67	ZAK	0.62768004
68	LATS2	0.62466035
69	WEE1	0.60546077
70	MAPK12	0.59749163
71	STK4	0.58077497
72	NEK1	0.57205758
73	CDK1	0.56982289
74	PAK1	0.55697482
75	CSNK2A2	0.54969664
76	ATR	0.54334004
77	BMX	0.53096700
78	CHUK	0.52692760
79	MAPK11	0.52062492
80	CSNK2A1	0.50772592
81	MAPK13	0.48752425
82	FLT3	0.48593852
83	CSNK1E	0.48382328
84	RPS6KA2	0.47417643
85	RPS6KA5	0.45091451
86	PDK1	0.44550205
87	ILK	0.40322471
88	IKBKB	0.39990907
89	NTRK2	0.39581529
90	MAP3K1	0.38674735
91	PRKG1	0.37318571
92	PBK	0.36267326
93	PDPK1	0.35152584
94	CDK11A	0.34593571
95	NME1	0.32937619
96	MTOR	0.31715616
97	MAPK10	0.30579349
98	RPS6KA1	0.29628003
99	RPS6KB2	0.28770310
100	TNK2	0.27849514

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	5.06604820
2	Cell cycle_Homo sapiens_hsa04110	4.06432506
3	Ribosome_Homo sapiens_hsa03010	3.21649979
4	Base excision repair_Homo sapiens_hsa03410	3.20157897
5	Mismatch repair_Homo sapiens_hsa03430	3.10726451
6	Nucleotide excision repair_Homo sapiens_hsa03420	2.78428335
7	Oocyte meiosis_Homo sapiens_hsa04114	2.71051490
8	RNA transport_Homo sapiens_hsa03013	2.56329823
9	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.47312691
10	DNA replication_Homo sapiens_hsa03030	2.36154160
11	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.36059972
12	mRNA surveillance pathway_Homo sapiens_hsa03015	2.33655162
13	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.26194611
14	One carbon pool by folate_Homo sapiens_hsa00670	2.12533771
15	Folate biosynthesis_Homo sapiens_hsa00790	2.03278920
16	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.02491014
17	RNA degradation_Homo sapiens_hsa03018	1.99849252
18	Homologous recombination_Homo sapiens_hsa03440	1.92994248
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.86170282
20	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.81366933
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.67670615
22	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.63837065
23	Thyroid cancer_Homo sapiens_hsa05216	1.61876233
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.60283665
25	Huntingtons disease_Homo sapiens_hsa05016	1.60072302
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.59116391
27	Nicotine addiction_Homo sapiens_hsa05033	1.53166065
28	p53 signaling pathway_Homo sapiens_hsa04115	1.49061487
29	RNA polymerase_Homo sapiens_hsa03020	1.47185894
30	Parkinsons disease_Homo sapiens_hsa05012	1.42283585
31	Olfactory transduction_Homo sapiens_hsa04740	1.42266873
32	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.33622852
33	mTOR signaling pathway_Homo sapiens_hsa04150	1.30914740
34	Proteasome_Homo sapiens_hsa03050	1.30854048
35	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.29407972
36	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.25699342
37	Caffeine metabolism_Homo sapiens_hsa00232	1.25185325
38	Oxidative phosphorylation_Homo sapiens_hsa00190	1.10546466
39	Spliceosome_Homo sapiens_hsa03040	1.04376561
40	Pyruvate metabolism_Homo sapiens_hsa00620	0.97644922
41	Sulfur metabolism_Homo sapiens_hsa00920	0.93548794
42	Malaria_Homo sapiens_hsa05144	0.91281190
43	Cardiac muscle contraction_Homo sapiens_hsa04260	0.89775991
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.76331081
45	GABAergic synapse_Homo sapiens_hsa04727	0.75327075
46	Non-small cell lung cancer_Homo sapiens_hsa05223	0.71341450
47	Viral carcinogenesis_Homo sapiens_hsa05203	0.69693840
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.69452763
49	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.67979020
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.65376539
51	ABC transporters_Homo sapiens_hsa02010	0.63228310
52	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.60256588
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.57785871
54	Circadian rhythm_Homo sapiens_hsa04710	0.57649965
55	FoxO signaling pathway_Homo sapiens_hsa04068	0.56922577
56	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.56584755
57	Morphine addiction_Homo sapiens_hsa05032	0.54755141
58	Taste transduction_Homo sapiens_hsa04742	0.53567318
59	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.51174099
60	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.50066202
61	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.49256711
62	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.48765864
63	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.43873403
64	Sulfur relay system_Homo sapiens_hsa04122	0.42838632
65	Prion diseases_Homo sapiens_hsa05020	0.42837788
66	Gap junction_Homo sapiens_hsa04540	0.42759168
67	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.36515319
68	Herpes simplex infection_Homo sapiens_hsa05168	0.36514254
69	Selenocompound metabolism_Homo sapiens_hsa00450	0.35928434
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.34243082
71	Purine metabolism_Homo sapiens_hsa00230	0.33135876
72	Metabolic pathways_Homo sapiens_hsa01100	0.32997166
73	Alzheimers disease_Homo sapiens_hsa05010	0.30903920
74	Insulin signaling pathway_Homo sapiens_hsa04910	0.27664226
75	Prolactin signaling pathway_Homo sapiens_hsa04917	0.27539909
76	Influenza A_Homo sapiens_hsa05164	0.27437824
77	Shigellosis_Homo sapiens_hsa05131	0.27119066
78	Adherens junction_Homo sapiens_hsa04520	0.27008648
79	Apoptosis_Homo sapiens_hsa04210	0.25419871
80	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.24729825
81	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.24693328
82	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.23832023
83	Bile secretion_Homo sapiens_hsa04976	0.23288516
84	Non-homologous end-joining_Homo sapiens_hsa03450	0.22659099
85	Fatty acid elongation_Homo sapiens_hsa00062	0.22655027
86	Renal cell carcinoma_Homo sapiens_hsa05211	0.22306714
87	MicroRNAs in cancer_Homo sapiens_hsa05206	0.21960900
88	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.21358642
89	Mineral absorption_Homo sapiens_hsa04978	0.20000583
90	Sphingolipid metabolism_Homo sapiens_hsa00600	0.19874476
91	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.19694063
92	ErbB signaling pathway_Homo sapiens_hsa04012	0.19080565
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.18420843
94	Collecting duct acid secretion_Homo sapiens_hsa04966	0.16432900
95	HTLV-I infection_Homo sapiens_hsa05166	0.13144335
96	Acute myeloid leukemia_Homo sapiens_hsa05221	0.10547824
97	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.10382737
98	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.10275600
99	Small cell lung cancer_Homo sapiens_hsa05222	0.09728977
100	Measles_Homo sapiens_hsa05162	0.09184801

OR8G3P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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