OR8S1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.08072370
2RNA localization (GO:0006403)4.37306619
3piRNA metabolic process (GO:0034587)4.37262976
4water-soluble vitamin biosynthetic process (GO:0042364)3.98571077
5L-fucose catabolic process (GO:0042355)3.95945700
6fucose catabolic process (GO:0019317)3.95945700
7L-fucose metabolic process (GO:0042354)3.95945700
8cytochrome complex assembly (GO:0017004)3.87433716
9negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.82594655
10positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.81581463
11protein complex biogenesis (GO:0070271)3.79679142
12maturation of 5.8S rRNA (GO:0000460)3.73318448
13regulation of cilium movement (GO:0003352)3.67517473
14indole-containing compound catabolic process (GO:0042436)3.54573384
15indolalkylamine catabolic process (GO:0046218)3.54573384
16tryptophan catabolic process (GO:0006569)3.54573384
17kynurenine metabolic process (GO:0070189)3.53308417
18mitochondrial respiratory chain complex assembly (GO:0033108)3.51850731
19secretory granule organization (GO:0033363)3.51097518
20pseudouridine synthesis (GO:0001522)3.50779661
21regulation of mitochondrial translation (GO:0070129)3.43301859
22preassembly of GPI anchor in ER membrane (GO:0016254)3.41024906
23detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.40892711
24behavioral response to nicotine (GO:0035095)3.31413730
25C4-dicarboxylate transport (GO:0015740)3.28801488
26arginine catabolic process (GO:0006527)3.28626565
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26116131
28pyrimidine nucleobase catabolic process (GO:0006208)3.19755399
29alanine transport (GO:0032328)3.17088706
30proline transport (GO:0015824)3.15425128
31cilium morphogenesis (GO:0060271)3.13926421
32protein polyglutamylation (GO:0018095)3.13151688
33positive regulation of translational initiation (GO:0045948)3.10652747
34retinal cone cell development (GO:0046549)3.10645454
35S-adenosylmethionine metabolic process (GO:0046500)3.10479777
36multicellular organism reproduction (GO:0032504)3.09425889
37indolalkylamine metabolic process (GO:0006586)3.07980450
38respiratory chain complex IV assembly (GO:0008535)3.07423476
39negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.05506062
40ubiquinone biosynthetic process (GO:0006744)3.03214632
41axoneme assembly (GO:0035082)3.02581249
42signal peptide processing (GO:0006465)3.02328072
43positive regulation of mitochondrial fission (GO:0090141)3.00386595
44epithelial cilium movement (GO:0003351)2.98797577
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96187489
46mitochondrial respiratory chain complex I assembly (GO:0032981)2.96187489
47NADH dehydrogenase complex assembly (GO:0010257)2.96187489
48neural tube formation (GO:0001841)2.95770243
49protein-cofactor linkage (GO:0018065)2.95092350
50DNA integration (GO:0015074)2.93266566
51platelet dense granule organization (GO:0060155)2.91747272
52regulation of neurotransmitter uptake (GO:0051580)2.91015722
53behavioral response to ethanol (GO:0048149)2.89420087
54DNA deamination (GO:0045006)2.87800830
55tryptophan metabolic process (GO:0006568)2.87134053
56mannosylation (GO:0097502)2.86673729
57regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.86272515
58L-ascorbic acid metabolic process (GO:0019852)2.84235012
59intraciliary transport (GO:0042073)2.83800468
60ubiquinone metabolic process (GO:0006743)2.80986952
61nucleobase catabolic process (GO:0046113)2.79850308
62rRNA modification (GO:0000154)2.79741385
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.77836668
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.77836668
65detection of light stimulus involved in sensory perception (GO:0050962)2.77221165
66detection of light stimulus involved in visual perception (GO:0050908)2.77221165
67negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74472613
68male meiosis I (GO:0007141)2.74269982
69ketone body metabolic process (GO:1902224)2.73399363
70cellular ketone body metabolic process (GO:0046950)2.69454283
71establishment of protein localization to mitochondrial membrane (GO:0090151)2.67562949
72positive regulation of signal transduction by p53 class mediator (GO:1901798)2.67015514
73C-terminal protein lipidation (GO:0006501)2.66863910
74reflex (GO:0060004)2.66501022
75negative regulation of axon guidance (GO:1902668)2.65381760
76gamma-aminobutyric acid transport (GO:0015812)2.65090926
77C-terminal protein amino acid modification (GO:0018410)2.64764877
78positive regulation of action potential (GO:0045760)2.64485493
79DNA double-strand break processing (GO:0000729)2.62284933
80negative regulation of signal transduction by p53 class mediator (GO:1901797)2.59656995
81nonmotile primary cilium assembly (GO:0035058)2.58993858
82negative regulation of axon extension involved in axon guidance (GO:0048843)2.58903220
83photoreceptor cell development (GO:0042461)2.58518311
84negative regulation of telomere maintenance (GO:0032205)2.58051606
85inositol phosphate catabolic process (GO:0071545)2.57475123
86negative regulation of membrane potential (GO:0045837)2.53825970
87amine catabolic process (GO:0009310)2.52020187
88cellular biogenic amine catabolic process (GO:0042402)2.52020187
89cilium organization (GO:0044782)2.51317579
90benzene-containing compound metabolic process (GO:0042537)2.48185370
91rRNA catabolic process (GO:0016075)2.47885096
92synapsis (GO:0007129)2.47840629
93negative regulation of heart rate (GO:0010459)2.47676285
94tRNA processing (GO:0008033)2.46923093
95male meiosis (GO:0007140)2.45332396
96recombinational repair (GO:0000725)2.45177248
97nitric oxide mediated signal transduction (GO:0007263)2.44749855
98cilium assembly (GO:0042384)2.44184123
99double-strand break repair via homologous recombination (GO:0000724)2.43826184
100auditory receptor cell stereocilium organization (GO:0060088)2.43192913

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.78649806
2IGF1R_20145208_ChIP-Seq_DFB_Human3.68566695
3VDR_22108803_ChIP-Seq_LS180_Human3.46293691
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.81248034
5GBX2_23144817_ChIP-Seq_PC3_Human2.77812579
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.58860304
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47832269
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.40857508
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.32849457
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31844061
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31679615
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25995110
13FUS_26573619_Chip-Seq_HEK293_Human2.10913240
14TAF15_26573619_Chip-Seq_HEK293_Human2.09889324
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05647116
16P300_19829295_ChIP-Seq_ESCs_Human2.03019008
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00988360
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92609021
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.83952742
20EWS_26573619_Chip-Seq_HEK293_Human1.83368527
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81962870
22ER_23166858_ChIP-Seq_MCF-7_Human1.81021399
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76718635
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73136829
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71649025
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64111475
27MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59750907
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.59117474
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54412305
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53184333
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52731659
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52625302
33CBP_20019798_ChIP-Seq_JUKART_Human1.52625302
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.50824358
35STAT3_23295773_ChIP-Seq_U87_Human1.50038637
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49584662
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48099321
38SMAD4_21799915_ChIP-Seq_A2780_Human1.47722414
39MYC_18940864_ChIP-ChIP_HL60_Human1.46707381
40KLF5_20875108_ChIP-Seq_MESCs_Mouse1.45083935
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43077298
42BCAT_22108803_ChIP-Seq_LS180_Human1.42905868
43AR_25329375_ChIP-Seq_VCAP_Human1.41330856
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40197232
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37201314
46RNF2_27304074_Chip-Seq_NSC_Mouse1.37178269
47ELK1_19687146_ChIP-ChIP_HELA_Human1.37018110
48* TCF4_22108803_ChIP-Seq_LS180_Human1.36124525
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35607800
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.35056407
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33728614
52* TCF4_23295773_ChIP-Seq_U87_Human1.33497814
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32854275
54NANOG_19829295_ChIP-Seq_ESCs_Human1.32046008
55SOX2_19829295_ChIP-Seq_ESCs_Human1.32046008
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31072217
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.29946097
58CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29204497
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.29003811
60TP53_22573176_ChIP-Seq_HFKS_Human1.28415847
61IRF1_19129219_ChIP-ChIP_H3396_Human1.28211469
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27195045
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.27002097
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26226150
65* RUNX2_22187159_ChIP-Seq_PCA_Human1.25005931
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24658767
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22689621
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22656121
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22656121
70TP53_16413492_ChIP-PET_HCT116_Human1.21965071
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21195503
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.19979292
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19454689
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18998485
75* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18437440
76* FOXA1_25329375_ChIP-Seq_VCAP_Human1.18437440
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18025768
78AR_21572438_ChIP-Seq_LNCaP_Human1.16524893
79VDR_23849224_ChIP-Seq_CD4+_Human1.15969188
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.14717604
81EZH2_22144423_ChIP-Seq_EOC_Human1.14455947
82NCOR_22424771_ChIP-Seq_293T_Human1.13158550
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.12545388
84P53_22387025_ChIP-Seq_ESCs_Mouse1.11131151
85AR_20517297_ChIP-Seq_VCAP_Human1.09631632
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09340540
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08256521
88HOXB7_26014856_ChIP-Seq_BT474_Human1.08083157
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07277676
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.03441183
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.03354411
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.03198755
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02602239
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01523673
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01458591
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01270446
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.00514575
98REST_21632747_ChIP-Seq_MESCs_Mouse0.99783688
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99623028
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99535977

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.32636251
2MP0006292_abnormal_olfactory_placode3.20410980
3MP0004147_increased_porphyrin_level2.74130344
4MP0001986_abnormal_taste_sensitivity2.68432000
5MP0003646_muscle_fatigue2.64257033
6MP0005084_abnormal_gallbladder_morpholo2.40206095
7MP0006072_abnormal_retinal_apoptosis2.36831983
8MP0008877_abnormal_DNA_methylation2.18986703
9MP0005551_abnormal_eye_electrophysiolog2.16967828
10MP0002102_abnormal_ear_morphology2.16207493
11MP0003880_abnormal_central_pattern2.15269553
12MP0000372_irregular_coat_pigmentation2.15084836
13MP0005646_abnormal_pituitary_gland2.14609477
14MP0003136_yellow_coat_color2.10757101
15MP0002938_white_spotting2.05145788
16MP0009046_muscle_twitch1.98530814
17MP0001968_abnormal_touch/_nociception1.97686686
18MP0008875_abnormal_xenobiotic_pharmacok1.91667928
19MP0008789_abnormal_olfactory_epithelium1.88779827
20MP0002837_dystrophic_cardiac_calcinosis1.85590383
21MP0002876_abnormal_thyroid_physiology1.85299896
22MP0005410_abnormal_fertilization1.78667195
23MP0005253_abnormal_eye_physiology1.76919795
24MP0009745_abnormal_behavioral_response1.67795449
25MP0001984_abnormal_olfaction1.65542996
26MP0008872_abnormal_physiological_respon1.65278681
27MP0001501_abnormal_sleep_pattern1.62894741
28MP0000631_abnormal_neuroendocrine_gland1.61249219
29MP0005645_abnormal_hypothalamus_physiol1.61188972
30MP0002736_abnormal_nociception_after1.58213333
31MP0002272_abnormal_nervous_system1.56912473
32MP0002163_abnormal_gland_morphology1.54122392
33MP0004133_heterotaxia1.51680839
34MP0001486_abnormal_startle_reflex1.50158405
35MP0008995_early_reproductive_senescence1.44681535
36MP0005394_taste/olfaction_phenotype1.41987542
37MP0005499_abnormal_olfactory_system1.41987542
38MP0000427_abnormal_hair_cycle1.37353220
39MP0006276_abnormal_autonomic_nervous1.37215990
40MP0002638_abnormal_pupillary_reflex1.33518434
41MP0000569_abnormal_digit_pigmentation1.32544692
42MP0008058_abnormal_DNA_repair1.28738315
43MP0002557_abnormal_social/conspecific_i1.26294080
44MP0003718_maternal_effect1.26078653
45MP0004142_abnormal_muscle_tone1.22249529
46MP0002751_abnormal_autonomic_nervous1.21742318
47MP0008775_abnormal_heart_ventricle1.20672142
48MP0000647_abnormal_sebaceous_gland1.20457330
49MP0003787_abnormal_imprinting1.18886423
50MP0004885_abnormal_endolymph1.15832891
51MP0004043_abnormal_pH_regulation1.15279303
52MP0005423_abnormal_somatic_nervous1.15124285
53MP0002277_abnormal_respiratory_mucosa1.11969046
54MP0002928_abnormal_bile_duct1.10117810
55MP0004134_abnormal_chest_morphology1.07513890
56MP0005379_endocrine/exocrine_gland_phen1.06847108
57MP0002572_abnormal_emotion/affect_behav1.06770208
58MP0003698_abnormal_male_reproductive1.06333959
59MP0002735_abnormal_chemical_nociception1.06174067
60MP0005332_abnormal_amino_acid1.05580126
61MP0002234_abnormal_pharynx_morphology1.04549517
62MP0006035_abnormal_mitochondrial_morpho1.03587248
63MP0001485_abnormal_pinna_reflex1.02647773
64MP0002160_abnormal_reproductive_system1.01874204
65MP0005386_behavior/neurological_phenoty1.00729044
66MP0004924_abnormal_behavior1.00729044
67MP0000778_abnormal_nervous_system1.00673665
68MP0002064_seizures1.00168072
69MP0001929_abnormal_gametogenesis0.98133700
70MP0002184_abnormal_innervation0.97794673
71MP0003252_abnormal_bile_duct0.95442627
72MP0001529_abnormal_vocalization0.94664358
73MP0004215_abnormal_myocardial_fiber0.94523889
74MP0005389_reproductive_system_phenotype0.93941535
75MP0003121_genomic_imprinting0.93252289
76MP0003635_abnormal_synaptic_transmissio0.92182684
77MP0001970_abnormal_pain_threshold0.90286125
78MP0002095_abnormal_skin_pigmentation0.89261758
79MP0005195_abnormal_posterior_eye0.88804135
80MP0003943_abnormal_hepatobiliary_system0.88537248
81MP0001756_abnormal_urination0.87700397
82MP0002733_abnormal_thermal_nociception0.87444228
83MP0003786_premature_aging0.87383339
84MP0002210_abnormal_sex_determination0.85756448
85MP0001764_abnormal_homeostasis0.85551439
86MP0003283_abnormal_digestive_organ0.85354236
87MP0006036_abnormal_mitochondrial_physio0.84007165
88MP0005083_abnormal_biliary_tract0.84004963
89MP0010386_abnormal_urinary_bladder0.82135611
90MP0002063_abnormal_learning/memory/cond0.81763474
91MP0005367_renal/urinary_system_phenotyp0.81569436
92MP0000516_abnormal_urinary_system0.81569436
93MP0003137_abnormal_impulse_conducting0.81270977
94MP0005248_abnormal_Harderian_gland0.81209656
95MP0005075_abnormal_melanosome_morpholog0.80691361
96MP0002752_abnormal_somatic_nervous0.79682427
97MP0003011_delayed_dark_adaptation0.78750562
98MP0002653_abnormal_ependyma_morphology0.77514982
99MP0000653_abnormal_sex_gland0.76964800
100MP0005187_abnormal_penis_morphology0.76943077

Predicted human phenotypes

RankGene SetZ-score
1Nephronophthisis (HP:0000090)4.08396686
2Pancreatic cysts (HP:0001737)4.05545623
3Pancreatic fibrosis (HP:0100732)4.01058122
4Abnormality of midbrain morphology (HP:0002418)3.94995883
5Molar tooth sign on MRI (HP:0002419)3.94995883
6True hermaphroditism (HP:0010459)3.85530519
7Abnormality of the renal medulla (HP:0100957)3.34612777
8Hyperventilation (HP:0002883)3.28097064
9Type II lissencephaly (HP:0007260)3.19737006
10Medial flaring of the eyebrow (HP:0010747)3.14527123
11Congenital stationary night blindness (HP:0007642)3.01761879
12Pendular nystagmus (HP:0012043)2.97599305
13Increased corneal curvature (HP:0100692)2.90485434
14Keratoconus (HP:0000563)2.90485434
15Attenuation of retinal blood vessels (HP:0007843)2.90161423
16Chronic hepatic failure (HP:0100626)2.73928018
17Hyperglycinuria (HP:0003108)2.72868948
18Abnormal rod and cone electroretinograms (HP:0008323)2.72313685
19Abnormality of the renal cortex (HP:0011035)2.71549627
20Congenital primary aphakia (HP:0007707)2.70746955
21Gait imbalance (HP:0002141)2.69388029
22Nephrogenic diabetes insipidus (HP:0009806)2.62993091
23Abolished electroretinogram (ERG) (HP:0000550)2.61320704
24Hemiparesis (HP:0001269)2.58733255
25Aplasia/Hypoplasia of the tongue (HP:0010295)2.53103918
26Cerebellar dysplasia (HP:0007033)2.48007469
27Cystic liver disease (HP:0006706)2.46792851
28Tubular atrophy (HP:0000092)2.43334490
29Concave nail (HP:0001598)2.43249135
30Lissencephaly (HP:0001339)2.42481691
31Abnormality of macular pigmentation (HP:0008002)2.41259535
32Renal cortical cysts (HP:0000803)2.38352273
33Acute necrotizing encephalopathy (HP:0006965)2.38128542
34Increased CSF lactate (HP:0002490)2.35939090
35Abnormality of serine family amino acid metabolism (HP:0010894)2.34958658
36Abnormality of glycine metabolism (HP:0010895)2.34958658
37Neoplasm of the adrenal cortex (HP:0100641)2.34661636
38Severe muscular hypotonia (HP:0006829)2.31306938
39Agitation (HP:0000713)2.31292993
40Large for gestational age (HP:0001520)2.27161605
41Mitochondrial inheritance (HP:0001427)2.26141328
42Acute encephalopathy (HP:0006846)2.23509590
43Adrenal hypoplasia (HP:0000835)2.23019214
44Decreased central vision (HP:0007663)2.19699054
45Hyperglycinemia (HP:0002154)2.17958975
46Sclerocornea (HP:0000647)2.17512707
47Congenital hepatic fibrosis (HP:0002612)2.16459427
48Genital tract atresia (HP:0001827)2.15925032
49Retinal dysplasia (HP:0007973)2.15367636
50Progressive macrocephaly (HP:0004481)2.14401157
51Abnormal drinking behavior (HP:0030082)2.13793857
52Polydipsia (HP:0001959)2.13793857
53Gaze-evoked nystagmus (HP:0000640)2.13574354
54Hypothermia (HP:0002045)2.07059858
55Methylmalonic acidemia (HP:0002912)2.06559962
56Broad-based gait (HP:0002136)2.06439912
57Postaxial foot polydactyly (HP:0001830)2.05649769
58Tachypnea (HP:0002789)2.05353856
59Vaginal atresia (HP:0000148)2.04187781
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02415181
61Absent/shortened dynein arms (HP:0200106)2.01760360
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.01760360
63Aplasia/Hypoplasia of the tibia (HP:0005772)2.01458432
64Absent speech (HP:0001344)2.01223296
65Hepatocellular necrosis (HP:0001404)1.97299554
66Bony spicule pigmentary retinopathy (HP:0007737)1.94775367
67Abnormality of proline metabolism (HP:0010907)1.94496853
68Hydroxyprolinuria (HP:0003080)1.94496853
69Preaxial hand polydactyly (HP:0001177)1.94140065
70Furrowed tongue (HP:0000221)1.93128851
713-Methylglutaconic aciduria (HP:0003535)1.92215789
72Intestinal atresia (HP:0011100)1.91811027
73Abnormal mitochondria in muscle tissue (HP:0008316)1.90317079
74Ketoacidosis (HP:0001993)1.90152901
75Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89976364
76Progressive inability to walk (HP:0002505)1.87454172
77Abnormal respiratory epithelium morphology (HP:0012253)1.85882901
78Abnormal respiratory motile cilium morphology (HP:0005938)1.85882901
79Cerebral hypomyelination (HP:0006808)1.84944346
80Drooling (HP:0002307)1.84166628
81Postaxial hand polydactyly (HP:0001162)1.83391187
82Hepatic necrosis (HP:0002605)1.82503844
83Anencephaly (HP:0002323)1.82234940
84Methylmalonic aciduria (HP:0012120)1.81636459
85Aganglionic megacolon (HP:0002251)1.80240971
86Rib fusion (HP:0000902)1.80227034
87Febrile seizures (HP:0002373)1.79519345
88Abnormality of the fovea (HP:0000493)1.78749998
89Aplasia/Hypoplasia of the fovea (HP:0008060)1.78275790
90Hypoplasia of the fovea (HP:0007750)1.78275790
91Occipital encephalocele (HP:0002085)1.77508260
92Abnormality of alanine metabolism (HP:0010916)1.76940907
93Hyperalaninemia (HP:0003348)1.76940907
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76940907
95Optic disc pallor (HP:0000543)1.76361000
96Submucous cleft hard palate (HP:0000176)1.76252140
97Inability to walk (HP:0002540)1.76180663
98Male pseudohermaphroditism (HP:0000037)1.73602527
99Poor coordination (HP:0002370)1.72417137
100Lethargy (HP:0001254)1.72161409

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.34153445
2NUAK13.19627955
3WNK33.14435487
4MAP4K22.94279058
5RIPK12.61079081
6CASK2.43869564
7TRIM282.09176252
8ADRBK22.09113119
9ZAK2.08433615
10BMPR1B2.06545231
11STK38L2.05053145
12MAPK132.05018734
13FGFR21.87509390
14PRKCI1.83039067
15OXSR11.80824210
16GRK11.80815344
17BCR1.78715476
18MKNK21.75795827
19INSRR1.72177877
20PRKCE1.69941125
21EIF2AK31.69616582
22PAK31.61647425
23TAOK31.58784170
24TNIK1.56359870
25MAP3K41.46080640
26STK391.45891895
27PINK11.42557804
28BCKDK1.41406882
29DYRK21.29436364
30BMPR21.26861909
31PDK21.26528851
32PLK21.24733954
33CSNK1G21.21349620
34CDK191.18542806
35PRKCG1.17454982
36MAP2K71.16594061
37CSNK1G31.15774163
38EPHA41.13461457
39NTRK21.09723878
40CSNK1G11.06893909
41CSNK1A1L1.05287544
42MKNK10.97854225
43PRKD30.94153274
44ACVR1B0.93438888
45MARK10.90080500
46MST40.89494745
47WNK40.87309496
48TIE10.85844610
49FLT30.82972639
50RPS6KA40.81790647
51ADRBK10.75278849
52ERBB30.74460376
53TLK10.71555719
54VRK10.70345579
55STK380.69957795
56PLK30.67447865
57DAPK30.61238539
58NME10.60115322
59PRKCZ0.59473004
60MUSK0.57973884
61PHKG10.57761179
62PHKG20.57761179
63IKBKB0.56391924
64PTK2B0.56004113
65AKT30.54827484
66PKN10.54524497
67FER0.54322876
68DYRK30.53318898
69VRK20.53297800
70BRSK20.52976996
71PRKCQ0.51361027
72NTRK30.48927071
73PRKD20.46866196
74MAP4K10.46532625
75EPHA30.46436524
76NEK10.45552103
77IRAK10.44327328
78TXK0.43987156
79PRKACA0.43903814
80CSNK1A10.43601903
81DAPK20.41953494
82PIK3CA0.41319564
83PLK40.40940264
84CAMK2A0.40544354
85RPS6KA50.38205069
86PASK0.37074439
87ATR0.36695610
88ATM0.36159872
89PLK10.36016788
90GRK50.35231624
91CSNK1D0.34796440
92PRKCA0.34761601
93DYRK1A0.34459103
94MARK30.32764559
95STK110.32439477
96KIT0.30151912
97TEC0.29721740
98WEE10.29302760
99PRKAA10.29142690
100KSR10.27888995

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.39177550
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.98950745
3Phototransduction_Homo sapiens_hsa047442.59401263
4Protein export_Homo sapiens_hsa030602.54030229
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.37512872
6Caffeine metabolism_Homo sapiens_hsa002322.35465446
7Butanoate metabolism_Homo sapiens_hsa006502.34242516
8Nicotine addiction_Homo sapiens_hsa050331.90517193
9Maturity onset diabetes of the young_Homo sapiens_hsa049501.88871257
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88673462
11Nitrogen metabolism_Homo sapiens_hsa009101.86760001
12Oxidative phosphorylation_Homo sapiens_hsa001901.84357726
13Selenocompound metabolism_Homo sapiens_hsa004501.76803182
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71917454
15Regulation of autophagy_Homo sapiens_hsa041401.69935480
16Tryptophan metabolism_Homo sapiens_hsa003801.63693611
17Linoleic acid metabolism_Homo sapiens_hsa005911.61926446
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60350300
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59221912
20Fanconi anemia pathway_Homo sapiens_hsa034601.57075740
21Propanoate metabolism_Homo sapiens_hsa006401.54959184
22RNA polymerase_Homo sapiens_hsa030201.49756566
23RNA degradation_Homo sapiens_hsa030181.44100171
24Homologous recombination_Homo sapiens_hsa034401.43352090
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41178674
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39638188
27Peroxisome_Homo sapiens_hsa041461.39046723
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35548026
29Proteasome_Homo sapiens_hsa030501.34817574
30Sulfur relay system_Homo sapiens_hsa041221.32536510
31Tyrosine metabolism_Homo sapiens_hsa003501.28169401
32Parkinsons disease_Homo sapiens_hsa050121.26730915
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21831565
34Taste transduction_Homo sapiens_hsa047421.20779335
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.19931620
36* Olfactory transduction_Homo sapiens_hsa047401.19916941
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18740658
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17716494
39Chemical carcinogenesis_Homo sapiens_hsa052041.16929957
40Non-homologous end-joining_Homo sapiens_hsa034501.15144871
41Collecting duct acid secretion_Homo sapiens_hsa049661.15039534
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14985972
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.12522873
44Ether lipid metabolism_Homo sapiens_hsa005651.10181143
45Lysine degradation_Homo sapiens_hsa003101.05450023
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.05437062
47Glutathione metabolism_Homo sapiens_hsa004801.05202260
48beta-Alanine metabolism_Homo sapiens_hsa004101.03422196
49Basal transcription factors_Homo sapiens_hsa030221.02973381
50ABC transporters_Homo sapiens_hsa020101.02590231
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99040184
52Insulin secretion_Homo sapiens_hsa049110.96369492
53Mineral absorption_Homo sapiens_hsa049780.96343652
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93763787
55Huntingtons disease_Homo sapiens_hsa050160.92866643
56Circadian entrainment_Homo sapiens_hsa047130.89268367
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86606079
58Glycerolipid metabolism_Homo sapiens_hsa005610.83626059
59Retinol metabolism_Homo sapiens_hsa008300.82921365
60Morphine addiction_Homo sapiens_hsa050320.82511782
61Salivary secretion_Homo sapiens_hsa049700.81167553
62Fatty acid metabolism_Homo sapiens_hsa012120.80951306
63Purine metabolism_Homo sapiens_hsa002300.79948744
64One carbon pool by folate_Homo sapiens_hsa006700.77257522
65Metabolic pathways_Homo sapiens_hsa011000.75080793
66Fatty acid elongation_Homo sapiens_hsa000620.74771749
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74590232
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72424638
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72389430
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71710382
71Fatty acid degradation_Homo sapiens_hsa000710.70059853
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69565697
73Alzheimers disease_Homo sapiens_hsa050100.68638022
74GABAergic synapse_Homo sapiens_hsa047270.68193427
75Cardiac muscle contraction_Homo sapiens_hsa042600.65364701
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62773552
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.62420304
78Fat digestion and absorption_Homo sapiens_hsa049750.62307210
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57862845
80RNA transport_Homo sapiens_hsa030130.57839048
81Glutamatergic synapse_Homo sapiens_hsa047240.57753825
82Circadian rhythm_Homo sapiens_hsa047100.56063228
83Arachidonic acid metabolism_Homo sapiens_hsa005900.55798078
84Arginine and proline metabolism_Homo sapiens_hsa003300.55110771
85Serotonergic synapse_Homo sapiens_hsa047260.54748432
86Pyrimidine metabolism_Homo sapiens_hsa002400.54356541
87Ovarian steroidogenesis_Homo sapiens_hsa049130.50534012
88Asthma_Homo sapiens_hsa053100.48938649
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.48872384
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48537988
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47293024
92Steroid biosynthesis_Homo sapiens_hsa001000.46898221
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44158283
94Synaptic vesicle cycle_Homo sapiens_hsa047210.42790185
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41818107
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40062412
97Amphetamine addiction_Homo sapiens_hsa050310.39264549
98Dopaminergic synapse_Homo sapiens_hsa047280.39146902
99Sphingolipid metabolism_Homo sapiens_hsa006000.36872454
100Type I diabetes mellitus_Homo sapiens_hsa049400.36628858

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