OR9N1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal ganglion cell axon guidance (GO:0031290)7.28595776
2cell wall macromolecule catabolic process (GO:0016998)6.87721927
3positive regulation of protein deacetylation (GO:0090312)6.80887026
4negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)6.40251801
5neurotransmitter-gated ion channel clustering (GO:0072578)5.94999710
6RNA destabilization (GO:0050779)5.79182499
7cell wall macromolecule metabolic process (GO:0044036)5.77750409
8protein localization to cilium (GO:0061512)5.73040528
9cellular ketone body metabolic process (GO:0046950)5.70350683
10somite rostral/caudal axis specification (GO:0032525)5.60337516
11detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)5.52179757
12forebrain neuron development (GO:0021884)5.44041559
13cholesterol biosynthetic process (GO:0006695)5.14162591
14neuronal stem cell maintenance (GO:0097150)5.12189022
15ketone body metabolic process (GO:1902224)5.07303754
16response to folic acid (GO:0051593)4.92233770
17positive regulation of action potential (GO:0045760)4.88071321
18exploration behavior (GO:0035640)4.80947288
19membrane budding (GO:0006900)4.79602180
20detection of chemical stimulus involved in sensory perception of taste (GO:0050912)4.73221264
21regulation of protein deacetylation (GO:0090311)4.71381066
22intraciliary transport (GO:0042073)4.51594653
23sterol biosynthetic process (GO:0016126)4.42561024
24protein localization to synapse (GO:0035418)4.30157183
25left/right axis specification (GO:0070986)4.27130138
26cranial nerve morphogenesis (GO:0021602)4.22592420
27sympathetic nervous system development (GO:0048485)4.18166228
28hemoglobin metabolic process (GO:0020027)4.08067876
29epithelial cilium movement (GO:0003351)4.07743698
30spinal cord association neuron differentiation (GO:0021527)4.04778012
31positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.99713889
32behavioral response to ethanol (GO:0048149)3.98859218
33regulation of timing of cell differentiation (GO:0048505)3.98554652
34cellular response to cholesterol (GO:0071397)3.95944549
35calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.95275520
36central nervous system neuron development (GO:0021954)3.95220118
37mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.92983096
38positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.92983096
39layer formation in cerebral cortex (GO:0021819)3.86690709
40positive regulation of oligodendrocyte differentiation (GO:0048714)3.81827643
41regulation of development, heterochronic (GO:0040034)3.80076682
42homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)3.79829593
43negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.74038669
44positive regulation of dendritic spine morphogenesis (GO:0061003)3.73482899
45gastrulation with mouth forming second (GO:0001702)3.66892499
46maturation of 5.8S rRNA (GO:0000460)3.66700263
47short-term memory (GO:0007614)3.63092552
48regulation of penile erection (GO:0060405)3.55443857
49neural tube formation (GO:0001841)3.54235109
50negative regulation of signal transduction by p53 class mediator (GO:1901797)3.53958646
51regulation of somitogenesis (GO:0014807)3.53332381
52positive regulation of sodium ion transmembrane transport (GO:1902307)3.51054255
53interkinetic nuclear migration (GO:0022027)3.50476864
54ADP metabolic process (GO:0046031)3.46564579
55molting cycle (GO:0042303)3.45219070
56hair cycle (GO:0042633)3.45219070
57cell differentiation in spinal cord (GO:0021515)3.44206740
58interferon-gamma production (GO:0032609)3.36626168
59response to misfolded protein (GO:0051788)3.34390288
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33143880
61positive regulation of cellular amide metabolic process (GO:0034250)3.31767316
62cardiac right ventricle morphogenesis (GO:0003215)3.31048714
63alkaloid metabolic process (GO:0009820)3.30770787
64regulation of action potential (GO:0098900)3.29514329
65isoprenoid biosynthetic process (GO:0008299)3.28580892
66nonmotile primary cilium assembly (GO:0035058)3.27622758
67protein localization to microtubule cytoskeleton (GO:0072698)3.25033173
68negative regulation of chemotaxis (GO:0050922)3.22783931
69cilium movement (GO:0003341)3.21801546
70neuron recognition (GO:0008038)3.20545957
71cellular response to sterol (GO:0036315)3.19820030
72apoptotic process involved in development (GO:1902742)3.16098507
73axon regeneration (GO:0031103)3.12934734
74cellular response to nitric oxide (GO:0071732)3.11108800
75positive regulation of dendritic spine development (GO:0060999)3.07066306
76behavioral response to nicotine (GO:0035095)3.06595785
77positive regulation of CREB transcription factor activity (GO:0032793)3.06043930
78spinal cord motor neuron differentiation (GO:0021522)3.05495993
79dendritic spine morphogenesis (GO:0060997)3.04098542
80forebrain neuron differentiation (GO:0021879)3.02815458
81circadian sleep/wake cycle process (GO:0022410)3.00530327
82platelet dense granule organization (GO:0060155)2.99101784
83cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.93113352
84cell-cell adhesion (GO:0098609)2.91238430
85ubiquinone metabolic process (GO:0006743)2.90766979
86regulation of telomere maintenance (GO:0032204)2.86553044
87left/right pattern formation (GO:0060972)2.84331706
88behavioral response to cocaine (GO:0048148)2.84106157
89regulation of synapse assembly (GO:0051963)2.82803631
90cerebral cortex neuron differentiation (GO:0021895)2.81589940
91regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)2.80270180
92axoneme assembly (GO:0035082)2.79469554
93substrate-independent telencephalic tangential migration (GO:0021826)2.76474608
94substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.76474608
95protein localization to cytoskeleton (GO:0044380)2.75950584
96mitochondrial fission (GO:0000266)2.72008602
97positive regulation of mitochondrial fission (GO:0090141)2.71780958
98negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.67628830
99developmental pigmentation (GO:0048066)2.67562729
100regulation of beta-amyloid formation (GO:1902003)2.67329426

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse6.87979153
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.16452123
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.81463208
4VDR_22108803_ChIP-Seq_LS180_Human3.38844938
5EZH2_22144423_ChIP-Seq_EOC_Human3.30096741
6FUS_26573619_Chip-Seq_HEK293_Human2.98580316
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71110836
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.61264799
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.53434122
10ZNF274_21170338_ChIP-Seq_K562_Hela2.50948699
11GBX2_23144817_ChIP-Seq_PC3_Human2.43325795
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.30589560
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.26257022
14AR_21572438_ChIP-Seq_LNCaP_Human2.16498352
15SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.11847504
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03321111
17CBX2_27304074_Chip-Seq_ESCs_Mouse1.99771789
18PIAS1_25552417_ChIP-Seq_VCAP_Human1.93225111
19POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.89129045
20TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89129045
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88075811
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85545468
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.80435832
24RNF2_27304074_Chip-Seq_NSC_Mouse1.79407094
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74546050
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.72222050
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.67058118
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63784391
29P300_19829295_ChIP-Seq_ESCs_Human1.59878143
30EWS_26573619_Chip-Seq_HEK293_Human1.58517625
31ER_23166858_ChIP-Seq_MCF-7_Human1.58225431
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57959600
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57391861
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57280728
35CBP_20019798_ChIP-Seq_JUKART_Human1.56049017
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56049017
37TAF15_26573619_Chip-Seq_HEK293_Human1.55717133
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.53428681
39IGF1R_20145208_ChIP-Seq_DFB_Human1.52318573
40KLF5_20875108_ChIP-Seq_MESCs_Mouse1.50486412
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50339941
42SMAD4_21799915_ChIP-Seq_A2780_Human1.48079246
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41734779
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41402095
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41295129
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40941736
47STAT3_23295773_ChIP-Seq_U87_Human1.40395846
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39926144
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34641141
50TAL1_26923725_Chip-Seq_HPCs_Mouse1.33995729
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33767534
52RUNX2_22187159_ChIP-Seq_PCA_Human1.33634146
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32305974
54TCF4_23295773_ChIP-Seq_U87_Human1.31960771
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31819871
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27952312
57TP53_18474530_ChIP-ChIP_U2OS_Human1.27619978
58KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25943859
59FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.23642211
60BCAT_22108803_ChIP-Seq_LS180_Human1.21283384
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19545221
62KDM2B_26808549_Chip-Seq_REH_Human1.17786616
63SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17230756
64AR_25329375_ChIP-Seq_VCAP_Human1.16874550
65TP53_22573176_ChIP-Seq_HFKS_Human1.15224619
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.14856508
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14040680
68JUN_21703547_ChIP-Seq_K562_Human1.10653643
69ERG_20517297_ChIP-Seq_VCAP_Human1.10334288
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09830929
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.07424936
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07134465
73TCF4_22108803_ChIP-Seq_LS180_Human1.07009662
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05222478
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04515326
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.04419499
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03642096
78P53_22387025_ChIP-Seq_ESCs_Mouse1.03489061
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02200536
80NANOG_19829295_ChIP-Seq_ESCs_Human1.02086416
81SOX2_19829295_ChIP-Seq_ESCs_Human1.02086416
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01593138
83NCOR_22424771_ChIP-Seq_293T_Human1.00992783
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00682382
85REST_18959480_ChIP-ChIP_MESCs_Mouse0.99874657
86NANOG_18555785_Chip-Seq_ESCs_Mouse0.99773914
87TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99183917
88TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98921672
89BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97219552
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96247225
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96148270
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95651803
93REST_21632747_ChIP-Seq_MESCs_Mouse0.95617932
94SMAD4_21741376_ChIP-Seq_EPCs_Human0.95223927
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.90580611
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.89694478
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89414206
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89359090
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.88440496
100POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88418479

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005367_renal/urinary_system_phenotyp5.19596155
2MP0000516_abnormal_urinary_system5.19596155
3MP0005171_absent_coat_pigmentation4.73963013
4MP0005670_abnormal_white_adipose4.11889315
5MP0003880_abnormal_central_pattern3.77862730
6MP0004133_heterotaxia3.43187332
7MP0000372_irregular_coat_pigmentation3.28651823
8MP0003890_abnormal_embryonic-extraembry3.01240443
9MP0003183_abnormal_peptide_metabolism2.98151569
10MP0002938_white_spotting2.90577932
11MP0008961_abnormal_basal_metabolism2.77025201
12MP0003195_calcinosis2.50033200
13MP0000569_abnormal_digit_pigmentation2.48181385
14MP0010368_abnormal_lymphatic_system2.28015913
15MP0002736_abnormal_nociception_after2.26614937
16MP0003221_abnormal_cardiomyocyte_apopto2.22249533
17MP0001501_abnormal_sleep_pattern1.96697026
18MP0006072_abnormal_retinal_apoptosis1.92961391
19MP0001486_abnormal_startle_reflex1.77905913
20MP0001485_abnormal_pinna_reflex1.73472093
21MP0006276_abnormal_autonomic_nervous1.68535983
22MP0002095_abnormal_skin_pigmentation1.66197792
23MP0004859_abnormal_synaptic_plasticity1.65213845
24MP0004043_abnormal_pH_regulation1.60987565
25MP0004215_abnormal_myocardial_fiber1.59891337
26MP0002735_abnormal_chemical_nociception1.59772167
27MP0002751_abnormal_autonomic_nervous1.58498236
28MP0001529_abnormal_vocalization1.54427392
29MP0000955_abnormal_spinal_cord1.51918973
30MP0001968_abnormal_touch/_nociception1.48868229
31MP0000534_abnormal_ureter_morphology1.47396142
32MP0003136_yellow_coat_color1.46918154
33MP0002822_catalepsy1.44474869
34MP0002249_abnormal_larynx_morphology1.41864330
35MP0002572_abnormal_emotion/affect_behav1.41233668
36MP0005253_abnormal_eye_physiology1.34749279
37MP0006292_abnormal_olfactory_placode1.31550051
38MP0003119_abnormal_digestive_system1.27049508
39MP0009046_muscle_twitch1.25928693
40MP0005187_abnormal_penis_morphology1.22668890
41MP0002234_abnormal_pharynx_morphology1.18944485
42MP0000751_myopathy1.17697585
43MP0010329_abnormal_lipoprotein_level1.17272900
44MP0005085_abnormal_gallbladder_physiolo1.16694499
45MP0008569_lethality_at_weaning1.09928543
46MP0006138_congestive_heart_failure1.08719125
47MP0000681_abnormal_thyroid_gland1.08698070
48MP0004885_abnormal_endolymph1.06090454
49MP0002063_abnormal_learning/memory/cond1.05151878
50MP0002928_abnormal_bile_duct1.04994304
51MP0005174_abnormal_tail_pigmentation1.01568397
52MP0009745_abnormal_behavioral_response0.98726723
53MP0000778_abnormal_nervous_system0.96027920
54MP0004742_abnormal_vestibular_system0.93655720
55MP0002882_abnormal_neuron_morphology0.92435773
56MP0002090_abnormal_vision0.91720930
57MP0003122_maternal_imprinting0.89963474
58MP0003938_abnormal_ear_development0.86589583
59MP0005391_vision/eye_phenotype0.85453357
60MP0000631_abnormal_neuroendocrine_gland0.85369053
61MP0002067_abnormal_sensory_capabilities0.85322182
62MP0002127_abnormal_cardiovascular_syste0.84412928
63MP0002752_abnormal_somatic_nervous0.84270090
64MP0000026_abnormal_inner_ear0.83580420
65MP0002184_abnormal_innervation0.83311432
66MP0009697_abnormal_copulation0.82813141
67MP0004145_abnormal_muscle_electrophysio0.82204935
68MP0000465_gastrointestinal_hemorrhage0.82091614
69MP0005377_hearing/vestibular/ear_phenot0.80650286
70MP0003878_abnormal_ear_physiology0.80650286
71MP0000049_abnormal_middle_ear0.80462680
72MP0003635_abnormal_synaptic_transmissio0.80271470
73MP0002272_abnormal_nervous_system0.79988944
74MP0005248_abnormal_Harderian_gland0.77843175
75MP0002152_abnormal_brain_morphology0.77622093
76MP0008789_abnormal_olfactory_epithelium0.76893139
77MP0004811_abnormal_neuron_physiology0.74263994
78MP0005195_abnormal_posterior_eye0.73529495
79MP0005551_abnormal_eye_electrophysiolog0.73369318
80MP0003121_genomic_imprinting0.73240937
81MP0008057_abnormal_DNA_replication0.72692159
82MP0002638_abnormal_pupillary_reflex0.72332730
83MP0001440_abnormal_grooming_behavior0.71404089
84MP0000678_abnormal_parathyroid_gland0.70684697
85MP0002557_abnormal_social/conspecific_i0.70115918
86MP0002064_seizures0.69868494
87MP0009250_abnormal_appendicular_skeleto0.69514364
88MP0003137_abnormal_impulse_conducting0.67645246
89MP0002092_abnormal_eye_morphology0.67376722
90MP0002111_abnormal_tail_morphology0.66546038
91MP0002282_abnormal_trachea_morphology0.65810822
92MP0004270_analgesia0.64646237
93MP0002229_neurodegeneration0.64037333
94MP0003861_abnormal_nervous_system0.62974257
95MP0002837_dystrophic_cardiac_calcinosis0.62797332
96MP0001293_anophthalmia0.61987825
97MP0005083_abnormal_biliary_tract0.59949425
98MP0004085_abnormal_heartbeat0.59758165
99MP0005448_abnormal_energy_balance0.59747168
100MP0002066_abnormal_motor_capabilities/c0.59312908

Predicted human phenotypes

RankGene SetZ-score
1Failure to thrive in infancy (HP:0001531)8.13247302
2Febrile seizures (HP:0002373)5.48432067
3Split foot (HP:0001839)4.70251911
4Congenital sensorineural hearing impairment (HP:0008527)3.88769239
5Renal hypoplasia (HP:0000089)3.75953821
6Focal motor seizures (HP:0011153)3.74501164
7Rib fusion (HP:0000902)3.58589784
8Severe global developmental delay (HP:0011344)3.26774882
9Broad alveolar ridges (HP:0000187)3.11763027
10Abnormal auditory evoked potentials (HP:0006958)3.10800957
11Patchy hypopigmentation of hair (HP:0011365)3.08740641
12Intestinal atresia (HP:0011100)3.08439386
13Congenital, generalized hypertrichosis (HP:0004540)3.06537970
14Medial flaring of the eyebrow (HP:0010747)3.04961682
15Progressive external ophthalmoplegia (HP:0000590)3.02647298
16Methylmalonic acidemia (HP:0002912)2.98124801
17Gait imbalance (HP:0002141)2.95661471
18Papillary thyroid carcinoma (HP:0002895)2.93114412
19Congenital primary aphakia (HP:0007707)2.88997043
20External ophthalmoplegia (HP:0000544)2.80124122
21Median cleft lip (HP:0000161)2.77750199
22Shoulder girdle muscle weakness (HP:0003547)2.77301627
23Hyperglycinemia (HP:0002154)2.71532508
24Abnormality of the axillary hair (HP:0100134)2.67973786
25Abnormality of secondary sexual hair (HP:0009888)2.67973786
26Hypoplastic pelvis (HP:0008839)2.67628720
27Molar tooth sign on MRI (HP:0002419)2.63729932
28Abnormality of midbrain morphology (HP:0002418)2.63729932
29Progressive cerebellar ataxia (HP:0002073)2.63143436
30Myelomeningocele (HP:0002475)2.59219329
31Thyroid carcinoma (HP:0002890)2.56041889
32Complete atrioventricular canal defect (HP:0001674)2.54536775
33Short humerus (HP:0005792)2.50706966
34Abnormal respiratory epithelium morphology (HP:0012253)2.49833394
35Abnormal respiratory motile cilium morphology (HP:0005938)2.49833394
36Methylmalonic aciduria (HP:0012120)2.49791247
37Poor coordination (HP:0002370)2.49046017
38Parakeratosis (HP:0001036)2.47560891
39High anterior hairline (HP:0009890)2.46381224
40Pelvic girdle muscle weakness (HP:0003749)2.42624148
41White forelock (HP:0002211)2.42577880
42Neonatal respiratory distress (HP:0002643)2.40936731
43Tubulointerstitial nephritis (HP:0001970)2.38537690
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.36591522
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.36282435
46Absent/shortened dynein arms (HP:0200106)2.36282435
47Anomalous pulmonary venous return (HP:0010772)2.35481720
48Mutism (HP:0002300)2.35381578
49Aplasia/hypoplasia of the humerus (HP:0006507)2.35242687
50Nephrogenic diabetes insipidus (HP:0009806)2.34731966
51Adactyly (HP:0009776)2.34616232
52Narrow forehead (HP:0000341)2.34466852
53Cortical visual impairment (HP:0100704)2.34041790
54Amyotrophic lateral sclerosis (HP:0007354)2.32405652
55Cutaneous finger syndactyly (HP:0010554)2.30167481
56Meningocele (HP:0002435)2.28473899
57Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.25266593
58Short 4th metacarpal (HP:0010044)2.25266593
59Abnormality of placental membranes (HP:0011409)2.23238224
60Amniotic constriction ring (HP:0009775)2.23238224
61Abnormality of the renal medulla (HP:0100957)2.17716710
62Abnormality of the shoulder girdle musculature (HP:0001435)2.17580951
63Abnormality of the hip-girdle musculature (HP:0001445)2.17107036
64Abnormality of the musculature of the pelvis (HP:0001469)2.17107036
65Hyperkalemia (HP:0002153)2.15105391
66Epidermoid cyst (HP:0200040)2.14583153
67Supernumerary spleens (HP:0009799)2.13751222
68Postaxial hand polydactyly (HP:0001162)2.12823064
69Long foot (HP:0001833)2.07167811
70True hermaphroditism (HP:0010459)2.05276398
71Abnormality of abdominal situs (HP:0011620)2.03047488
72Abdominal situs inversus (HP:0003363)2.03047488
73Aplasia/Hypoplasia involving the musculature (HP:0001460)2.01998870
74Abnormality of the pulmonary veins (HP:0011718)2.00600158
75Heterochromia iridis (HP:0001100)1.99957396
76Vaginal atresia (HP:0000148)1.99246496
77Atrioventricular canal defect (HP:0006695)1.97768661
78Hypokalemic alkalosis (HP:0001949)1.96841209
79Colon cancer (HP:0003003)1.94648203
80Abnormal ciliary motility (HP:0012262)1.91836312
81Genital tract atresia (HP:0001827)1.90988495
82Gastrointestinal atresia (HP:0002589)1.89883673
83Blue irides (HP:0000635)1.88852428
84Confusion (HP:0001289)1.87407393
85Tented upper lip vermilion (HP:0010804)1.86641459
86Proximal placement of thumb (HP:0009623)1.86329798
87Cutaneous syndactyly (HP:0012725)1.85993535
88Oligodactyly (HP:0012165)1.83182052
89Pancreatic cysts (HP:0001737)1.82758686
90Synostosis of carpal bones (HP:0005048)1.81060489
91Synostosis involving the elbow (HP:0003938)1.79462994
92Humeroradial synostosis (HP:0003041)1.79462994
93Specific learning disability (HP:0001328)1.79156563
94Pancreatic fibrosis (HP:0100732)1.78975001
95Hemivertebrae (HP:0002937)1.77413495
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77230136
97Large for gestational age (HP:0001520)1.76081130
98Hallux valgus (HP:0001822)1.75780034
99Smooth philtrum (HP:0000319)1.75206596
100Abnormality of homocysteine metabolism (HP:0010919)1.74462284

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF15.96233583
2FGFR35.44715638
3MAP3K45.01852822
4MAP2K74.89413127
5WNK33.75430399
6DYRK1A3.13610192
7MAP3K63.10345252
8MAP2K42.85032791
9EPHB12.70463589
10BCR2.64430773
11EPHA32.11529516
12MAPK132.00404057
13MARK11.97506474
14MKNK21.78093068
15MAP4K21.73670862
16MKNK11.51926644
17PASK1.40548051
18FRK1.40015905
19SRPK11.38583095
20PAK61.36356308
21ADRBK21.34806917
22CAMKK21.33543395
23CAMKK11.31779731
24WNK41.24469400
25CSNK1G31.21883789
26CSNK1A1L1.18232977
27DYRK1B1.10134331
28CSNK1G21.05049839
29DAPK21.04874398
30MAP3K51.03924573
31PNCK0.98399481
32TRIM280.94358290
33CDK30.92706731
34CSNK1G10.91875168
35DYRK30.88302610
36ERBB30.86460156
37CASK0.85992380
38BRSK20.74833268
39INSRR0.73223930
40MATK0.72812423
41EPHA40.69300234
42UHMK10.69087071
43ERBB20.67979842
44STK390.67209505
45BCKDK0.66520383
46PRKCG0.65662430
47NUAK10.62949435
48NTRK10.62363065
49PKN10.61881158
50DYRK20.58618119
51OXSR10.55003954
52PINK10.54187182
53ADRBK10.50942814
54ATR0.49963657
55PAK30.49912390
56CDK80.48421960
57TESK10.48357166
58MAPK150.47577633
59PRKD30.46911473
60CAMK2A0.46305461
61CAMK40.45574403
62CLK10.44339984
63WNK10.43972959
64SGK10.42192096
65CAMK2B0.41388305
66NEK10.40895595
67TAOK30.40721389
68CSNK1E0.36887666
69VRK20.35558394
70PRKACB0.35244808
71GRK10.34837472
72IRAK40.34320711
73PLK20.34130256
74INSR0.34087001
75BRSK10.31834771
76MOS0.31706881
77NTRK20.31557379
78PRKACA0.31274286
79VRK10.31108299
80MAP2K60.29672831
81CHUK0.28351632
82LIMK10.28183904
83PRKAA20.27829804
84RPS6KA40.27795914
85PRKCE0.27700117
86CDK190.26125501
87PIK3CA0.24082180
88CDK140.23628514
89IRAK20.23144561
90BMPR1B0.22690964
91CAMK2D0.22468946
92OBSCN0.20675028
93CSNK1A10.20382646
94IRAK10.19979236
95PRKCB0.19797365
96CAMK10.17915159
97PRKCZ0.14969352
98NME10.14205998
99TRPM70.13736913
100PRKACG0.13559807

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.86984965
2Steroid biosynthesis_Homo sapiens_hsa001004.95355757
3Propanoate metabolism_Homo sapiens_hsa006404.17590649
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.42106476
5Pyruvate metabolism_Homo sapiens_hsa006203.35291863
6Butanoate metabolism_Homo sapiens_hsa006503.29248071
7Cysteine and methionine metabolism_Homo sapiens_hsa002703.09635954
8Taste transduction_Homo sapiens_hsa047422.90869869
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02235540
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78044026
11Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.76286534
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68898156
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58789408
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57440475
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50334533
16Basal transcription factors_Homo sapiens_hsa030221.47401409
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32058514
18Linoleic acid metabolism_Homo sapiens_hsa005911.30631311
19Fat digestion and absorption_Homo sapiens_hsa049751.27211178
20Caffeine metabolism_Homo sapiens_hsa002321.25272259
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24941762
22Nitrogen metabolism_Homo sapiens_hsa009101.23211011
23Circadian rhythm_Homo sapiens_hsa047101.20009359
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17505168
25Nicotine addiction_Homo sapiens_hsa050331.11907102
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11343678
27Axon guidance_Homo sapiens_hsa043601.09058644
28Arginine and proline metabolism_Homo sapiens_hsa003301.06668443
29Glucagon signaling pathway_Homo sapiens_hsa049220.94764549
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92954262
31Cyanoamino acid metabolism_Homo sapiens_hsa004600.89988310
32Tryptophan metabolism_Homo sapiens_hsa003800.88525642
33Dopaminergic synapse_Homo sapiens_hsa047280.87748118
34Spliceosome_Homo sapiens_hsa030400.86330797
35Glutamatergic synapse_Homo sapiens_hsa047240.84118394
36Ether lipid metabolism_Homo sapiens_hsa005650.80234662
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74597035
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74518188
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74190876
40Olfactory transduction_Homo sapiens_hsa047400.74079446
41Collecting duct acid secretion_Homo sapiens_hsa049660.73045127
42Protein export_Homo sapiens_hsa030600.71176186
43Oxidative phosphorylation_Homo sapiens_hsa001900.70397678
44Peroxisome_Homo sapiens_hsa041460.70174089
45Retinol metabolism_Homo sapiens_hsa008300.70122509
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70017202
47Morphine addiction_Homo sapiens_hsa050320.69971203
48Long-term depression_Homo sapiens_hsa047300.65802022
49Circadian entrainment_Homo sapiens_hsa047130.63023599
50One carbon pool by folate_Homo sapiens_hsa006700.62357721
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59315814
52Metabolic pathways_Homo sapiens_hsa011000.58697373
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53658303
54GABAergic synapse_Homo sapiens_hsa047270.51978258
55TGF-beta signaling pathway_Homo sapiens_hsa043500.50672121
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49953082
57Nucleotide excision repair_Homo sapiens_hsa034200.49785274
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46960632
59Phototransduction_Homo sapiens_hsa047440.45824031
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45301163
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.44439490
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43648754
63AMPK signaling pathway_Homo sapiens_hsa041520.43201940
64Serotonergic synapse_Homo sapiens_hsa047260.42635165
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41614020
66Fatty acid metabolism_Homo sapiens_hsa012120.41319076
67Gastric acid secretion_Homo sapiens_hsa049710.40543272
68Huntingtons disease_Homo sapiens_hsa050160.39039439
69Parkinsons disease_Homo sapiens_hsa050120.37461008
70Fanconi anemia pathway_Homo sapiens_hsa034600.36326369
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35498522
72Chemical carcinogenesis_Homo sapiens_hsa052040.35275286
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.33719918
74ABC transporters_Homo sapiens_hsa020100.33388352
75Biosynthesis of amino acids_Homo sapiens_hsa012300.32126773
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30779334
77Cocaine addiction_Homo sapiens_hsa050300.30406433
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29910627
79Cholinergic synapse_Homo sapiens_hsa047250.29000282
80Oxytocin signaling pathway_Homo sapiens_hsa049210.26668687
81Glycerolipid metabolism_Homo sapiens_hsa005610.25041741
82RNA degradation_Homo sapiens_hsa030180.24789095
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24239560
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22712335
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21124661
86Salivary secretion_Homo sapiens_hsa049700.21082183
87Arachidonic acid metabolism_Homo sapiens_hsa005900.20840669
88Cardiac muscle contraction_Homo sapiens_hsa042600.20141102
89Purine metabolism_Homo sapiens_hsa002300.20110362
90Oocyte meiosis_Homo sapiens_hsa041140.19505591
91Vitamin digestion and absorption_Homo sapiens_hsa049770.18777144
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.18636116
93Tyrosine metabolism_Homo sapiens_hsa003500.18087261
94Selenocompound metabolism_Homo sapiens_hsa004500.16764685
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16344000
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15676009
97Alcoholism_Homo sapiens_hsa050340.14857974
98Basal cell carcinoma_Homo sapiens_hsa052170.14320731
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13488078
100African trypanosomiasis_Homo sapiens_hsa051430.13327968

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