OR9Q1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)7.11201336
2ribosomal small subunit biogenesis (GO:0042274)4.34818095
3cell proliferation in forebrain (GO:0021846)4.32310340
4dendritic spine morphogenesis (GO:0060997)4.12984228
5protein neddylation (GO:0045116)4.05145250
6viral transcription (GO:0019083)4.02649791
7ribosomal small subunit assembly (GO:0000028)4.02039559
8maturation of SSU-rRNA (GO:0030490)3.98994051
9RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.91425275
10tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.91425275
11translational termination (GO:0006415)3.82521835
12chaperone-mediated protein transport (GO:0072321)3.81223158
13energy coupled proton transport, down electrochemical gradient (GO:0015985)3.73492497
14ATP synthesis coupled proton transport (GO:0015986)3.73492497
15substrate-independent telencephalic tangential migration (GO:0021826)3.65428026
16substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.65428026
17pyrimidine nucleobase catabolic process (GO:0006208)3.53131511
18transmission of nerve impulse (GO:0019226)3.51268314
19retinal ganglion cell axon guidance (GO:0031290)3.48563367
20indolalkylamine metabolic process (GO:0006586)3.33145257
21seminiferous tubule development (GO:0072520)3.30130913
22establishment of protein localization to mitochondrial membrane (GO:0090151)3.30120812
23protein polyglutamylation (GO:0018095)3.26486548
24membrane repolarization during action potential (GO:0086011)3.24015081
25protein complex biogenesis (GO:0070271)3.23765625
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.21509557
27cardiovascular system development (GO:0072358)3.20928712
28establishment of mitochondrion localization (GO:0051654)3.19999266
29nonmotile primary cilium assembly (GO:0035058)3.18202347
30signal peptide processing (GO:0006465)3.17060841
31translational elongation (GO:0006414)3.15235595
32membrane repolarization (GO:0086009)3.06391625
33detection of light stimulus involved in sensory perception (GO:0050962)3.05889570
34detection of light stimulus involved in visual perception (GO:0050908)3.05889570
35kynurenine metabolic process (GO:0070189)3.05821043
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04813819
37regulation of female receptivity (GO:0045924)3.04190458
38membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.04093394
39viral life cycle (GO:0019058)3.03306530
40axon ensheathment in central nervous system (GO:0032291)3.02772968
41central nervous system myelination (GO:0022010)3.02772968
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02254374
43axonal fasciculation (GO:0007413)3.01914837
44negative regulation of transcription regulatory region DNA binding (GO:2000678)3.01656304
45GTP biosynthetic process (GO:0006183)3.01555476
46fat-soluble vitamin catabolic process (GO:0042363)2.99411460
47vitamin catabolic process (GO:0009111)2.99411460
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98698701
49somite development (GO:0061053)2.97493875
50indole-containing compound catabolic process (GO:0042436)2.97063582
51indolalkylamine catabolic process (GO:0046218)2.97063582
52tryptophan catabolic process (GO:0006569)2.97063582
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95876463
54water-soluble vitamin biosynthetic process (GO:0042364)2.95800396
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.94514950
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92465382
57mitochondrial respiratory chain complex I assembly (GO:0032981)2.92465382
58NADH dehydrogenase complex assembly (GO:0010257)2.92465382
59ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.92106063
60cotranslational protein targeting to membrane (GO:0006613)2.90054166
61protein targeting to ER (GO:0045047)2.88440703
62negative regulation of response to food (GO:0032096)2.87178432
63negative regulation of appetite (GO:0032099)2.87178432
64mitochondrial respiratory chain complex assembly (GO:0033108)2.83821841
65establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.81551872
66mitochondrion transport along microtubule (GO:0047497)2.81551872
67head development (GO:0060322)2.80533313
68neuron recognition (GO:0008038)2.78896691
69adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.76762894
70nucleobase catabolic process (GO:0046113)2.74952462
71establishment of protein localization to endoplasmic reticulum (GO:0072599)2.74771811
72regulation of potassium ion transmembrane transporter activity (GO:1901016)2.74545971
73cellular protein complex disassembly (GO:0043624)2.73531044
74postsynaptic membrane organization (GO:0001941)2.71165004
75positive regulation of potassium ion transmembrane transport (GO:1901381)2.70373504
76epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69002226
77protein localization to endoplasmic reticulum (GO:0070972)2.68633769
78neurofilament cytoskeleton organization (GO:0060052)2.67354026
79respiratory electron transport chain (GO:0022904)2.62648565
80G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61089018
81neuronal action potential propagation (GO:0019227)2.60857757
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60332358
83electron transport chain (GO:0022900)2.59809747
84epithelial cilium movement (GO:0003351)2.59424048
85short-term memory (GO:0007614)2.57035830
86regulation of potassium ion transmembrane transport (GO:1901379)2.56399435
87UTP biosynthetic process (GO:0006228)2.55621501
88axonemal dynein complex assembly (GO:0070286)2.55460215
89synaptic transmission, cholinergic (GO:0007271)2.55104851
90female mating behavior (GO:0060180)2.54497565
91adaptation of signaling pathway (GO:0023058)2.53667350
92serotonin metabolic process (GO:0042428)2.52068896
93regulation of membrane repolarization (GO:0060306)2.51398272
94L-fucose catabolic process (GO:0042355)2.50154339
95fucose catabolic process (GO:0019317)2.50154339
96L-fucose metabolic process (GO:0042354)2.50154339
97base-excision repair, AP site formation (GO:0006285)2.46445838
98nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.45738499
99multicellular organismal signaling (GO:0035637)2.45390901
100DNA deamination (GO:0045006)2.45054118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.43232664
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.41419100
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.24542479
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.67059106
5VDR_22108803_ChIP-Seq_LS180_Human2.62073887
6ZNF274_21170338_ChIP-Seq_K562_Hela2.55938517
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.43892616
8REST_21632747_ChIP-Seq_MESCs_Mouse2.34111505
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29925468
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.24488866
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.21313574
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19550589
13IRF1_19129219_ChIP-ChIP_H3396_Human2.06730157
14EZH2_27294783_Chip-Seq_ESCs_Mouse1.99731471
15SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96430875
16JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95828757
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.95283901
18GBX2_23144817_ChIP-Seq_PC3_Human1.92271725
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80869575
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79418250
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78752521
22REST_18959480_ChIP-ChIP_MESCs_Mouse1.73236911
23RNF2_27304074_Chip-Seq_NSC_Mouse1.66940448
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64519417
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64519417
26* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58736748
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58005511
28IGF1R_20145208_ChIP-Seq_DFB_Human1.57233672
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.56801036
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55204922
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54299887
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52598522
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51686434
34EWS_26573619_Chip-Seq_HEK293_Human1.51032761
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49865141
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46410008
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45480815
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45480815
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44518423
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40622145
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40434716
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36849455
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.36316704
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36265478
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36093507
46ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35931662
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34732729
48FUS_26573619_Chip-Seq_HEK293_Human1.34650772
49NCOR_22424771_ChIP-Seq_293T_Human1.29614783
50P300_19829295_ChIP-Seq_ESCs_Human1.26774595
51P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26375838
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26192014
53* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26154046
54TP53_22573176_ChIP-Seq_HFKS_Human1.21110676
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20859205
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20377545
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19672648
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19423541
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18279467
60SMAD4_21799915_ChIP-Seq_A2780_Human1.18184287
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12658738
62SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12478252
63ER_23166858_ChIP-Seq_MCF-7_Human1.10851146
64* TCF4_23295773_ChIP-Seq_U87_Human1.09614401
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.09420171
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.08932595
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.08892899
68TAF2_19829295_ChIP-Seq_ESCs_Human1.08787275
69SMAD3_21741376_ChIP-Seq_ESCs_Human1.06617058
70BCAT_22108803_ChIP-Seq_LS180_Human1.06180222
71DROSHA_22980978_ChIP-Seq_HELA_Human1.05015967
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04312047
73* CBP_20019798_ChIP-Seq_JUKART_Human1.04156004
74* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04156004
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03024236
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02871538
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02787357
78STAT3_23295773_ChIP-Seq_U87_Human1.01873799
79NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99693718
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99604282
81KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99493951
82* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99295044
83GATA1_26923725_Chip-Seq_HPCs_Mouse0.99051253
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98531944
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98269222
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97014523
87NANOG_20526341_ChIP-Seq_ESCs_Human0.96567264
88RUNX2_22187159_ChIP-Seq_PCA_Human0.95741207
89PIAS1_25552417_ChIP-Seq_VCAP_Human0.95010793
90MYC_19829295_ChIP-Seq_ESCs_Human0.94763955
91SOX2_19829295_ChIP-Seq_ESCs_Human0.94661517
92NANOG_19829295_ChIP-Seq_ESCs_Human0.94661517
93SMAD3_21741376_ChIP-Seq_EPCs_Human0.93977076
94AR_25329375_ChIP-Seq_VCAP_Human0.93941837
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93871875
96P53_21459846_ChIP-Seq_SAOS-2_Human0.93071729
97AR_21572438_ChIP-Seq_LNCaP_Human0.92891677
98* TCF4_22108803_ChIP-Seq_LS180_Human0.92670913
99JUN_21703547_ChIP-Seq_K562_Human0.91514908
100POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90942605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.64047290
2MP0006292_abnormal_olfactory_placode3.93410991
3MP0003646_muscle_fatigue3.48136862
4MP0003787_abnormal_imprinting3.17857211
5MP0003123_paternal_imprinting3.10337498
6MP0003121_genomic_imprinting2.42411740
7MP0002653_abnormal_ependyma_morphology2.40095868
8MP0003122_maternal_imprinting2.38433876
9MP0002837_dystrophic_cardiac_calcinosis2.29391487
10MP0002163_abnormal_gland_morphology2.25764341
11MP0005423_abnormal_somatic_nervous2.11997230
12MP0002160_abnormal_reproductive_system2.11842737
13MP0006276_abnormal_autonomic_nervous2.11318039
14MP0008877_abnormal_DNA_methylation2.06249531
15MP0005551_abnormal_eye_electrophysiolog1.88667003
16MP0004142_abnormal_muscle_tone1.88537230
17MP0002638_abnormal_pupillary_reflex1.78064186
18MP0008789_abnormal_olfactory_epithelium1.76498475
19MP0000778_abnormal_nervous_system1.75084161
20MP0002736_abnormal_nociception_after1.73896327
21MP0001968_abnormal_touch/_nociception1.67786291
22MP0009745_abnormal_behavioral_response1.66052898
23MP0002272_abnormal_nervous_system1.63494340
24MP0004885_abnormal_endolymph1.61950114
25MP0005389_reproductive_system_phenotype1.59611054
26MP0002557_abnormal_social/conspecific_i1.58124069
27MP0004130_abnormal_muscle_cell1.55924683
28MP0003635_abnormal_synaptic_transmissio1.54977524
29MP0004145_abnormal_muscle_electrophysio1.50824472
30MP0003136_yellow_coat_color1.46198333
31MP0004859_abnormal_synaptic_plasticity1.43111705
32MP0005394_taste/olfaction_phenotype1.42605502
33MP0005499_abnormal_olfactory_system1.42605502
34MP0000631_abnormal_neuroendocrine_gland1.42082274
35MP0002572_abnormal_emotion/affect_behav1.41991651
36MP0002063_abnormal_learning/memory/cond1.41023577
37MP0001440_abnormal_grooming_behavior1.40937048
38MP0000049_abnormal_middle_ear1.40053141
39MP0003880_abnormal_central_pattern1.38620334
40MP0005646_abnormal_pituitary_gland1.37806635
41MP0002184_abnormal_innervation1.37492616
42MP0001529_abnormal_vocalization1.34212300
43MP0001970_abnormal_pain_threshold1.32361231
44MP0000955_abnormal_spinal_cord1.32202660
45MP0005379_endocrine/exocrine_gland_phen1.28699559
46MP0002733_abnormal_thermal_nociception1.27710013
47MP0003195_calcinosis1.25420870
48MP0002928_abnormal_bile_duct1.24923917
49MP0002064_seizures1.21090004
50MP0005195_abnormal_posterior_eye1.19939945
51MP0002752_abnormal_somatic_nervous1.18832738
52MP0002734_abnormal_mechanical_nocicepti1.16918498
53MP0009046_muscle_twitch1.16545724
54MP0003283_abnormal_digestive_organ1.11359672
55MP0001986_abnormal_taste_sensitivity1.11234947
56MP0002938_white_spotting1.10140160
57MP0002882_abnormal_neuron_morphology1.09294203
58MP0002876_abnormal_thyroid_physiology1.09049033
59MP0003879_abnormal_hair_cell1.08300469
60MP0005645_abnormal_hypothalamus_physiol1.08217937
61MP0002095_abnormal_skin_pigmentation1.08095756
62MP0004133_heterotaxia1.07131755
63MP0003011_delayed_dark_adaptation1.05718342
64MP0003942_abnormal_urinary_system1.05060625
65MP0000026_abnormal_inner_ear1.04433909
66MP0009053_abnormal_anal_canal1.04057535
67MP0002102_abnormal_ear_morphology1.01145904
68MP0004742_abnormal_vestibular_system0.99858244
69MP0006072_abnormal_retinal_apoptosis0.98904909
70MP0005360_urolithiasis0.98049653
71MP0001486_abnormal_startle_reflex0.96602165
72MP0000372_irregular_coat_pigmentation0.96541745
73MP0002067_abnormal_sensory_capabilities0.95613673
74MP0001485_abnormal_pinna_reflex0.94982150
75MP0001919_abnormal_reproductive_system0.94407971
76MP0005386_behavior/neurological_phenoty0.93016792
77MP0004924_abnormal_behavior0.93016792
78MP0008872_abnormal_physiological_respon0.92451422
79MP0001905_abnormal_dopamine_level0.92182969
80MP0001984_abnormal_olfaction0.91773411
81MP0002234_abnormal_pharynx_morphology0.91475523
82MP0009384_cardiac_valve_regurgitation0.88725779
83MP0000534_abnormal_ureter_morphology0.88419053
84MP0001293_anophthalmia0.86736252
85MP0005253_abnormal_eye_physiology0.86199353
86MP0002229_neurodegeneration0.83808687
87MP0000230_abnormal_systemic_arterial0.83793065
88MP0003119_abnormal_digestive_system0.83704862
89MP0002152_abnormal_brain_morphology0.83007301
90MP0004858_abnormal_nervous_system0.81748760
91MP0001963_abnormal_hearing_physiology0.80030142
92MP0002210_abnormal_sex_determination0.79398786
93MP0008875_abnormal_xenobiotic_pharmacok0.79353406
94MP0008775_abnormal_heart_ventricle0.78362425
95MP0005187_abnormal_penis_morphology0.77995022
96MP0000427_abnormal_hair_cycle0.75778702
97MP0001188_hyperpigmentation0.75673593
98MP0003938_abnormal_ear_development0.74486326
99MP0002138_abnormal_hepatobiliary_system0.74353040
100MP0003936_abnormal_reproductive_system0.73253801

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)4.43425743
2Pendular nystagmus (HP:0012043)3.90391644
3Congenital stationary night blindness (HP:0007642)3.60703011
4Abnormal rod and cone electroretinograms (HP:0008323)3.44405521
5Reticulocytopenia (HP:0001896)3.42174386
6Myokymia (HP:0002411)3.40377469
7Abnormality of midbrain morphology (HP:0002418)3.34780720
8Molar tooth sign on MRI (HP:0002419)3.34780720
9Acute necrotizing encephalopathy (HP:0006965)3.33817747
10Decreased central vision (HP:0007663)3.22581006
11Medial flaring of the eyebrow (HP:0010747)3.19193508
12Hyperglycinemia (HP:0002154)3.17758514
13Pancreatic fibrosis (HP:0100732)3.14386579
14Acute encephalopathy (HP:0006846)3.12588570
15Abnormality of cells of the erythroid lineage (HP:0012130)3.06796938
16Septo-optic dysplasia (HP:0100842)3.01948008
17Gait imbalance (HP:0002141)3.00514179
18Agitation (HP:0000713)2.96947706
19Pancreatic cysts (HP:0001737)2.95227601
20True hermaphroditism (HP:0010459)2.93842325
21Abnormal mitochondria in muscle tissue (HP:0008316)2.93415600
22Progressive macrocephaly (HP:0004481)2.88715854
23Abolished electroretinogram (ERG) (HP:0000550)2.80845760
24Asplenia (HP:0001746)2.73026373
25Congenital primary aphakia (HP:0007707)2.72804451
26Nephronophthisis (HP:0000090)2.71689386
27Nephrogenic diabetes insipidus (HP:0009806)2.69388133
28Abnormal ciliary motility (HP:0012262)2.68982630
29Aplasia/Hypoplasia of the spleen (HP:0010451)2.64838891
30Increased corneal curvature (HP:0100692)2.61319442
31Keratoconus (HP:0000563)2.61319442
32Adrenal hypoplasia (HP:0000835)2.60965610
33Lissencephaly (HP:0001339)2.59276649
34Abnormal respiratory motile cilium physiology (HP:0012261)2.51597723
35Type II lissencephaly (HP:0007260)2.48672446
36Mitochondrial inheritance (HP:0001427)2.48609469
37Dynein arm defect of respiratory motile cilia (HP:0012255)2.46387117
38Absent/shortened dynein arms (HP:0200106)2.46387117
39Anencephaly (HP:0002323)2.42529594
40Abnormal number of erythroid precursors (HP:0012131)2.41999100
41Attenuation of retinal blood vessels (HP:0007843)2.38790158
42Pallor (HP:0000980)2.35527069
43Hyperthyroidism (HP:0000836)2.28784019
44Abnormal hemoglobin (HP:0011902)2.25906499
45Stenosis of the external auditory canal (HP:0000402)2.25804028
46Optic nerve hypoplasia (HP:0000609)2.25374608
47Increased CSF lactate (HP:0002490)2.25203738
48Short femoral neck (HP:0100864)2.20942329
49Growth hormone deficiency (HP:0000824)2.19063036
50Macrocytic anemia (HP:0001972)2.17110186
51Sclerocornea (HP:0000647)2.16480126
52Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.15220318
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.15127194
54Genital tract atresia (HP:0001827)2.14774020
55Vaginal atresia (HP:0000148)2.14743382
56Optic disc pallor (HP:0000543)2.14507760
57Abnormality of the renal medulla (HP:0100957)2.14115886
58Cystic liver disease (HP:0006706)2.12559933
59Pachygyria (HP:0001302)2.12059217
60Bony spicule pigmentary retinopathy (HP:0007737)2.09642325
61Poor coordination (HP:0002370)2.09347775
62Abnormality of alanine metabolism (HP:0010916)2.08859461
63Hyperalaninemia (HP:0003348)2.08859461
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08859461
65Enlarged kidneys (HP:0000105)2.05311823
66Metaphyseal dysplasia (HP:0100255)2.03986776
67Postaxial foot polydactyly (HP:0001830)2.02658192
68Broad-based gait (HP:0002136)2.02070939
69Osteomalacia (HP:0002749)2.01678888
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01291829
71Cerebral edema (HP:0002181)2.00372134
72Epileptic encephalopathy (HP:0200134)1.99322620
73Abnormality of the labia minora (HP:0012880)1.98720174
74Polyphagia (HP:0002591)1.97345343
75Dyskinesia (HP:0100660)1.96190650
76Abnormal respiratory motile cilium morphology (HP:0005938)1.95229928
77Abnormal respiratory epithelium morphology (HP:0012253)1.95229928
78Progressive cerebellar ataxia (HP:0002073)1.95171087
79Male pseudohermaphroditism (HP:0000037)1.94881356
80Absent thumb (HP:0009777)1.92958818
81Drooling (HP:0002307)1.89161174
82Abnormality of the 4th metacarpal (HP:0010012)1.87324963
83Hepatocellular necrosis (HP:0001404)1.85603420
84Abnormality of renal resorption (HP:0011038)1.82968479
85Neoplasm of the adrenal cortex (HP:0100641)1.82695658
86Hyperventilation (HP:0002883)1.82190761
87Symphalangism affecting the phalanges of the hand (HP:0009773)1.81913142
88Aplasia/Hypoplasia of the tongue (HP:0010295)1.80876049
89Abnormality of cochlea (HP:0000375)1.80800908
90Short 4th metacarpal (HP:0010044)1.78627822
91Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78627822
92Abnormality of the renal cortex (HP:0011035)1.77280367
93Renal Fanconi syndrome (HP:0001994)1.76796696
94Specific learning disability (HP:0001328)1.76292811
95Abnormality of DNA repair (HP:0003254)1.73270752
96Lipid accumulation in hepatocytes (HP:0006561)1.73008617
97Hepatoblastoma (HP:0002884)1.72567434
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.71813482
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70721650
100Focal seizures (HP:0007359)1.70470377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.09213136
2CASK2.62631031
3WNK32.52147469
4MARK12.41812888
5NTRK22.37654828
6WNK42.37580126
7BMPR1B2.28102834
8DYRK22.26216893
9MAP3K42.18841414
10GRK12.15285627
11TYRO32.02226323
12MAPK131.96585471
13PIK3CA1.79312571
14NUAK11.77321506
15MAP2K71.70771647
16PLK21.69655130
17NTRK31.69313008
18ADRBK21.65957133
19ACVR1B1.54233306
20EPHB21.53054693
21TIE11.50449124
22NME21.40167282
23STK391.36230915
24ZAK1.31708151
25PRKCG1.29655912
26PINK11.26125595
27CAMKK21.18085302
28PKN11.12612031
29INSRR1.10872116
30MINK11.05727776
31DMPK1.05315100
32ADRBK11.04476487
33STK111.03307646
34EPHA41.02112941
35PRKCZ0.99912878
36BCKDK0.97565683
37PRKACA0.96583254
38MAP3K110.94555926
39OXSR10.93615543
40BRAF0.93580335
41MAP3K90.92849940
42SGK2230.89903385
43SGK4940.89903385
44PRKD30.89302737
45DYRK30.86989982
46ERBB20.84872012
47PHKG10.81240299
48PHKG20.81240299
49CAMK2A0.80784866
50CAMK10.80080770
51RPS6KA20.79750501
52ABL20.77332916
53PAK30.75058660
54PRKCE0.74322305
55MAP2K20.73972908
56SGK20.73719647
57STK160.72740134
58PRKCQ0.71659482
59MAPK150.69383777
60CSNK1G20.68127074
61CDK50.67932200
62RPS6KA60.66597059
63ILK0.66507709
64FGFR20.66040524
65TGFBR10.62881133
66CAMKK10.58908013
67CDK190.58059002
68PRKACG0.56827647
69PRKCA0.56211748
70PRKCI0.55479486
71TRIM280.55093703
72SGK10.52508200
73PRKCH0.52396849
74GRK70.52175455
75MAP4K20.51261320
76CSNK1G30.50400522
77CSNK1D0.49296448
78PRKD20.46442639
79CSNK1A10.45942666
80LRRK20.45738989
81CSNK2A20.45349315
82PLK40.45135893
83RPS6KA30.44479461
84OBSCN0.43127413
85PRKG10.42557479
86LIMK10.42321697
87DYRK1A0.41763772
88CSNK2A10.41610724
89RPS6KA50.40900876
90DYRK1B0.40769618
91CSNK1A1L0.39694690
92RPS6KL10.39349038
93RPS6KC10.39349038
94RPS6KA40.39245270
95CAMK2B0.39207067
96PRKCD0.39000594
97PLK30.38231161
98AKT10.36757899
99TXK0.36573708
100CSNK1E0.35991300

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.92293117
2Oxidative phosphorylation_Homo sapiens_hsa001903.64992722
3Parkinsons disease_Homo sapiens_hsa050123.01276026
4Phototransduction_Homo sapiens_hsa047442.72288485
5Cardiac muscle contraction_Homo sapiens_hsa042602.65490180
6Nicotine addiction_Homo sapiens_hsa050332.60912842
7Huntingtons disease_Homo sapiens_hsa050162.30334029
8Alzheimers disease_Homo sapiens_hsa050102.19693690
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11563477
10Sulfur relay system_Homo sapiens_hsa041222.05156241
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.89085040
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.80082439
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.77867934
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77370945
15Tryptophan metabolism_Homo sapiens_hsa003801.74203767
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66028159
17Linoleic acid metabolism_Homo sapiens_hsa005911.65025399
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62759779
19Morphine addiction_Homo sapiens_hsa050321.60308609
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55604719
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51299983
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49279873
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48303208
24Retinol metabolism_Homo sapiens_hsa008301.46936887
25Butanoate metabolism_Homo sapiens_hsa006501.46461258
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.42705004
27Chemical carcinogenesis_Homo sapiens_hsa052041.41497695
28Insulin secretion_Homo sapiens_hsa049111.35205843
29RNA polymerase_Homo sapiens_hsa030201.29282486
30Homologous recombination_Homo sapiens_hsa034401.23468045
31Glutamatergic synapse_Homo sapiens_hsa047241.22730102
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21946577
33Caffeine metabolism_Homo sapiens_hsa002321.18833462
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18322168
35Nitrogen metabolism_Homo sapiens_hsa009101.17918260
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14937479
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14650201
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14485647
39RNA degradation_Homo sapiens_hsa030181.13510825
40* Olfactory transduction_Homo sapiens_hsa047401.13135762
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10689979
42GABAergic synapse_Homo sapiens_hsa047271.05911872
43Serotonergic synapse_Homo sapiens_hsa047261.05539855
44Circadian entrainment_Homo sapiens_hsa047130.99152331
45Fat digestion and absorption_Homo sapiens_hsa049750.97938953
46Steroid biosynthesis_Homo sapiens_hsa001000.97050148
47Fanconi anemia pathway_Homo sapiens_hsa034600.97048553
48Ether lipid metabolism_Homo sapiens_hsa005650.95792061
49Peroxisome_Homo sapiens_hsa041460.93675166
50Axon guidance_Homo sapiens_hsa043600.92446184
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92313134
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91282626
53Protein export_Homo sapiens_hsa030600.89703126
54Dopaminergic synapse_Homo sapiens_hsa047280.88996911
55beta-Alanine metabolism_Homo sapiens_hsa004100.88844204
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88717795
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.88434948
58Cocaine addiction_Homo sapiens_hsa050300.86394443
59Synaptic vesicle cycle_Homo sapiens_hsa047210.86146015
60Phenylalanine metabolism_Homo sapiens_hsa003600.79828076
61Cholinergic synapse_Homo sapiens_hsa047250.77548435
62Propanoate metabolism_Homo sapiens_hsa006400.77488519
63Glycerolipid metabolism_Homo sapiens_hsa005610.72654034
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72251144
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.70203406
66Taste transduction_Homo sapiens_hsa047420.68401583
67Hedgehog signaling pathway_Homo sapiens_hsa043400.67168741
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66411274
69Metabolic pathways_Homo sapiens_hsa011000.65656820
70Tyrosine metabolism_Homo sapiens_hsa003500.64725663
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.63395096
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.59336768
73Arginine and proline metabolism_Homo sapiens_hsa003300.59090042
74Collecting duct acid secretion_Homo sapiens_hsa049660.58384463
75Histidine metabolism_Homo sapiens_hsa003400.57957362
76Arachidonic acid metabolism_Homo sapiens_hsa005900.52567376
77Salivary secretion_Homo sapiens_hsa049700.51647424
78Starch and sucrose metabolism_Homo sapiens_hsa005000.51547351
79Gastric acid secretion_Homo sapiens_hsa049710.49818993
80Basal cell carcinoma_Homo sapiens_hsa052170.49712312
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.47404502
82Ovarian steroidogenesis_Homo sapiens_hsa049130.46607668
83cAMP signaling pathway_Homo sapiens_hsa040240.44796575
84Calcium signaling pathway_Homo sapiens_hsa040200.44560050
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.43726285
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43510953
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42344643
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40448347
89Fatty acid degradation_Homo sapiens_hsa000710.39113210
90Oxytocin signaling pathway_Homo sapiens_hsa049210.38415283
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38295638
92ABC transporters_Homo sapiens_hsa020100.36911004
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34659547
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34008279
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33771244
96Melanoma_Homo sapiens_hsa052180.33298096
97Pyrimidine metabolism_Homo sapiens_hsa002400.32518522
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32274750
99Basal transcription factors_Homo sapiens_hsa030220.31516442
100Amphetamine addiction_Homo sapiens_hsa050310.31277387

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