ORAI3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.12434135
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.12434135
3ribosomal small subunit assembly (GO:0000028)5.76499899
4antigen processing and presentation of endogenous antigen (GO:0019883)5.41616808
5DNA deamination (GO:0045006)4.64130920
6cellular response to zinc ion (GO:0071294)4.21397158
7response to peptidoglycan (GO:0032494)4.11834165
8viral transcription (GO:0019083)4.03012435
9antigen processing and presentation via MHC class Ib (GO:0002475)3.95013241
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.90627983
11response to interferon-beta (GO:0035456)3.87165531
12translational termination (GO:0006415)3.82390016
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.77519004
14Arp2/3 complex-mediated actin nucleation (GO:0034314)3.75942012
15positive regulation of B cell differentiation (GO:0045579)3.75110872
16platelet dense granule organization (GO:0060155)3.75041022
17negative regulation of phagocytosis (GO:0050765)3.65158594
18cotranslational protein targeting to membrane (GO:0006613)3.64473350
19protein targeting to ER (GO:0045047)3.63988308
20response to interferon-alpha (GO:0035455)3.61117750
21positive regulation of gamma-delta T cell activation (GO:0046645)3.60762813
22regulation of B cell receptor signaling pathway (GO:0050855)3.58614365
23detection of bacterium (GO:0016045)3.57731791
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.53265942
25detection of other organism (GO:0098543)3.50404363
26positive regulation by symbiont of host defense response (GO:0052509)3.47352104
27modulation by symbiont of host defense response (GO:0052031)3.47352104
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.47352104
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.47352104
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.47352104
31modulation by symbiont of host immune response (GO:0052553)3.47352104
32protein localization to endoplasmic reticulum (GO:0070972)3.46035577
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.45227482
34translational elongation (GO:0006414)3.44426356
35regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.43716303
36regulation of mast cell degranulation (GO:0043304)3.34303281
37definitive hemopoiesis (GO:0060216)3.32907381
38neutrophil activation involved in immune response (GO:0002283)3.26090781
39regulation of B cell differentiation (GO:0045577)3.22980088
40killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.12956870
41disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.12956870
42detection of external biotic stimulus (GO:0098581)3.10329854
43response to type I interferon (GO:0034340)3.08350174
44type I interferon signaling pathway (GO:0060337)3.07410574
45cellular response to type I interferon (GO:0071357)3.07410574
46regulation of myeloid leukocyte mediated immunity (GO:0002886)3.05233910
47negative regulation of erythrocyte differentiation (GO:0045647)3.03343271
48regulation of mast cell activation involved in immune response (GO:0033006)3.00353186
49neutrophil mediated immunity (GO:0002446)2.99904665
50immunoglobulin mediated immune response (GO:0016064)2.99124854
51defense response to protozoan (GO:0042832)2.98379944
52viral life cycle (GO:0019058)2.97865665
53megakaryocyte development (GO:0035855)2.96369573
54mature B cell differentiation involved in immune response (GO:0002313)2.95769666
55positive regulation of lamellipodium assembly (GO:0010592)2.92431656
56B cell receptor signaling pathway (GO:0050853)2.92150921
57cellular extravasation (GO:0045123)2.92115594
58respiratory burst (GO:0045730)2.91807015
59response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.85442973
60response to host immune response (GO:0052572)2.85442973
61production of molecular mediator involved in inflammatory response (GO:0002532)2.85055140
62regulation of antigen processing and presentation (GO:0002577)2.84588200
63pentose-phosphate shunt (GO:0006098)2.84276842
64telomere maintenance via semi-conservative replication (GO:0032201)2.83010511
65angiogenesis involved in wound healing (GO:0060055)2.81613573
66regulation of leukocyte degranulation (GO:0043300)2.81562486
67nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.81550243
68response to protozoan (GO:0001562)2.80848400
69ribosomal small subunit biogenesis (GO:0042274)2.79795560
70macrophage activation involved in immune response (GO:0002281)2.79463122
71detection of biotic stimulus (GO:0009595)2.77940693
72detection of molecule of bacterial origin (GO:0032490)2.77899782
73regulation of gamma-delta T cell differentiation (GO:0045586)2.74203267
74pinocytosis (GO:0006907)2.73796567
75DNA strand elongation involved in DNA replication (GO:0006271)2.73771140
76purine-containing compound salvage (GO:0043101)2.71813762
77regulation of natural killer cell differentiation (GO:0032823)2.71337108
78T cell homeostasis (GO:0043029)2.71080449
79regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.68568142
80endosome to melanosome transport (GO:0035646)2.68294034
81endosome to pigment granule transport (GO:0043485)2.68294034
82regulation of B cell apoptotic process (GO:0002902)2.67856586
83actin nucleation (GO:0045010)2.66830829
84negative regulation of granulocyte differentiation (GO:0030853)2.66725682
85DNA strand elongation (GO:0022616)2.64474272
86negative regulation of interleukin-12 production (GO:0032695)2.64368342
87positive regulation of lamellipodium organization (GO:1902745)2.64276093
88cellular protein complex disassembly (GO:0043624)2.63833504
89lymph node development (GO:0048535)2.62375180
90necroptotic process (GO:0070266)2.62048611
91xenobiotic catabolic process (GO:0042178)2.62045289
92negative regulation of innate immune response (GO:0045824)2.61463251
93myeloid dendritic cell activation (GO:0001773)2.60720592
94secretory granule organization (GO:0033363)2.60634937
95hyaluronan catabolic process (GO:0030214)2.60075240
96phosphatidylglycerol biosynthetic process (GO:0006655)2.59675954
97response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.59618158
98response to host (GO:0075136)2.59618158
99response to host defenses (GO:0052200)2.59618158
100positive regulation of antigen processing and presentation (GO:0002579)2.59405600
101toxin transport (GO:1901998)2.59282317
102B cell mediated immunity (GO:0019724)2.58318684
103translational initiation (GO:0006413)2.58266445
104regulation of dendritic cell antigen processing and presentation (GO:0002604)2.57066863
105myeloid leukocyte mediated immunity (GO:0002444)2.55901906
106respiratory chain complex IV assembly (GO:0008535)2.55712274
107regulation of macrophage cytokine production (GO:0010935)2.55666866
108mature B cell differentiation (GO:0002335)2.55610726
109negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.54256968
110myeloid cell activation involved in immune response (GO:0002275)2.53555193
111regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.53511220
112negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.52660278
113valine metabolic process (GO:0006573)2.52530146
114positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.52141440
115endothelium development (GO:0003158)2.51940779
116regulation of necroptotic process (GO:0060544)2.51682180
117positive regulation of natural killer cell differentiation (GO:0032825)2.51583264
118maturation of SSU-rRNA (GO:0030490)2.50183464
119execution phase of apoptosis (GO:0097194)2.50113555
120regulation of mast cell activation (GO:0033003)2.50044754
121peptidyl-glutamic acid carboxylation (GO:0017187)2.48920990
122protein carboxylation (GO:0018214)2.48920990
123NADPH regeneration (GO:0006740)2.47956724
124negative regulation of bone mineralization (GO:0030502)2.47825129
125negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.47793939
126negative regulation of cell killing (GO:0031342)2.47793939
127regulation of gamma-delta T cell activation (GO:0046643)2.47129046
128phagocytosis, engulfment (GO:0006911)2.46590895
129defense response to fungus (GO:0050832)2.46492788
130NIK/NF-kappaB signaling (GO:0038061)2.45767393
131neutrophil activation (GO:0042119)2.44787739
132amino sugar catabolic process (GO:0046348)2.44717102
133protein targeting to membrane (GO:0006612)2.44397871
134tricarboxylic acid metabolic process (GO:0072350)2.44358133
135regulation of superoxide anion generation (GO:0032928)2.43451287
136cellular response to interferon-beta (GO:0035458)2.42665659
137reactive oxygen species biosynthetic process (GO:1903409)2.41081694
138signal peptide processing (GO:0006465)2.41073877
139macrophage differentiation (GO:0030225)2.39520594
140Golgi transport vesicle coating (GO:0048200)2.38330471
141COPI coating of Golgi vesicle (GO:0048205)2.38330471
142positive regulation of fatty acid biosynthetic process (GO:0045723)2.38300527
143regulation of interferon-beta biosynthetic process (GO:0045357)2.38297968
144sequestering of metal ion (GO:0051238)2.38140492
145barbed-end actin filament capping (GO:0051016)2.37859298
146complement activation, alternative pathway (GO:0006957)2.36888184
147purine nucleotide salvage (GO:0032261)2.36342688
148deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.36274452
149positive regulation of chemokine secretion (GO:0090197)2.35827107
150negative regulation of cytokine production involved in immune response (GO:0002719)2.35763842
151negative regulation of T-helper cell differentiation (GO:0045623)2.35716532
152negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.35716532
153negative regulation of nitric oxide biosynthetic process (GO:0045019)2.35525193
154microglial cell activation (GO:0001774)2.35008549
155response to muramyl dipeptide (GO:0032495)2.33983990
156positive regulation of granulocyte differentiation (GO:0030854)2.33523346
157positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.32668393
158interferon-gamma-mediated signaling pathway (GO:0060333)2.30752123
159positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.30578871
160L-phenylalanine catabolic process (GO:0006559)2.30399088
161erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.30399088
162regulation of granulocyte differentiation (GO:0030852)2.28417843
163positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.28100935
164regulation of phagocytosis (GO:0050764)2.27325887
165leukocyte degranulation (GO:0043299)2.26867156
166regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.26585642
167positive regulation of tumor necrosis factor production (GO:0032760)2.25125833
168granulocyte activation (GO:0036230)2.24261288
169negative regulation of interleukin-6 production (GO:0032715)2.23642629

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.95696711
2E2F7_22180533_ChIP-Seq_HELA_Human3.85182977
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26981128
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.09833108
5SCL_19346495_ChIP-Seq_HPC-7_Human3.08896700
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.01910307
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.83063025
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.77633935
9* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.69740909
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.69479145
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.61540050
12GATA1_22025678_ChIP-Seq_K562_Human2.60892388
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.53898113
14VDR_21846776_ChIP-Seq_THP-1_Human2.45170635
15MYC_22102868_ChIP-Seq_BL_Human2.44213978
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.40810885
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39036813
18* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.35033257
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.32415913
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30886619
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16431222
22* SPI1_23547873_ChIP-Seq_NB4_Human2.14137341
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.09935494
24LXR_22292898_ChIP-Seq_THP-1_Human2.09869766
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06692909
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05029455
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03395228
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.97405869
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.96590795
30* IRF8_27001747_Chip-Seq_BMDM_Mouse1.94328112
31* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.89476481
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.89267045
33VDR_24763502_ChIP-Seq_THP-1_Human1.84397819
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83486872
35MAF_26560356_Chip-Seq_TH1_Human1.83241801
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.81578534
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81001940
38* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.80496341
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78924416
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.78923848
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78649427
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.78036817
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75893624
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.70225229
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.67606550
46* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.65537380
47MYB_26560356_Chip-Seq_TH2_Human1.65449834
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64849046
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64588258
50BCL6_27268052_Chip-Seq_Bcells_Human1.64264095
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61775505
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59587866
53* ELF1_20517297_ChIP-Seq_JURKAT_Human1.57348980
54* MYB_26560356_Chip-Seq_TH1_Human1.56768054
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54149981
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52407637
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.52295341
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51084701
59* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.51078438
60* GATA2_21666600_ChIP-Seq_HMVEC_Human1.49774192
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49242982
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49094972
63UTX_26944678_Chip-Seq_JUKART_Human1.45320574
64TCF7_22412390_ChIP-Seq_EML_Mouse1.44262934
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43576880
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41991369
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41865858
68GATA1_19941826_ChIP-Seq_K562_Human1.40933948
69BCOR_27268052_Chip-Seq_Bcells_Human1.39863152
70KDM2B_26808549_Chip-Seq_DND41_Human1.39424455
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.38876858
72JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37570516
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34945081
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34710511
75* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34124682
76* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33911999
77* SPI1_23127762_ChIP-Seq_K562_Human1.33753860
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33382428
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30310431
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30042683
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29550067
82PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28254123
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28060589
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26187279
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25420730
86VDR_23849224_ChIP-Seq_CD4+_Human1.24996693
87RXR_22158963_ChIP-Seq_LIVER_Mouse1.24785287
88CIITA_25753668_ChIP-Seq_RAJI_Human1.24199456
89VDR_24787735_ChIP-Seq_THP-1_Human1.24098534
90FOXP3_21729870_ChIP-Seq_TREG_Human1.23840792
91* GATA1_19941827_ChIP-Seq_MEL_Mouse1.23417731
92P68_20966046_ChIP-Seq_HELA_Human1.22533354
93MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22148850
94SPI1_20517297_ChIP-Seq_HL60_Human1.21432695
95SRF_21415370_ChIP-Seq_HL-1_Mouse1.21096148
96* ELK3_25401928_ChIP-Seq_HUVEC_Human1.19979639
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19467132
98SA1_27219007_Chip-Seq_ERYTHROID_Human1.19187086
99FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18730673
100LXR_22158963_ChIP-Seq_LIVER_Mouse1.18467628
101ETS1_20019798_ChIP-Seq_JURKAT_Human1.16207975
102XRN2_22483619_ChIP-Seq_HELA_Human1.14249853
103MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13738137
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13455126
105* NCOR1_26117541_ChIP-Seq_K562_Human1.12066538
106CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11628817
107RACK7_27058665_Chip-Seq_MCF-7_Human1.11450973
108CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11408314
109E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10494570
110RUNX_20019798_ChIP-Seq_JUKART_Human1.10256371
111CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10154419
112STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09165368
113MAF_26560356_Chip-Seq_TH2_Human1.08108897
114STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07831847
115VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07053832
116GABP_19822575_ChIP-Seq_HepG2_Human1.06260445
117GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05039594
118* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04899235
119PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04366727
120KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04257709
121ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04153256
122EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03990035
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03709233
124* P300_27268052_Chip-Seq_Bcells_Human1.03367346
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03227299
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03195163
127CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02935626
128PU_27001747_Chip-Seq_BMDM_Mouse1.02730016
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02252667
130* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01405279
131PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00911649
132TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00316591
133ZNF263_19887448_ChIP-Seq_K562_Human1.00221211
134FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00078366
135TFEB_21752829_ChIP-Seq_HELA_Human0.99784517
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99480687
137CTCF_26484167_Chip-Seq_Bcells_Mouse0.98868351
138* GATA3_27048872_Chip-Seq_THYMUS_Human0.98096103
139E2F1_20622854_ChIP-Seq_HELA_Human0.97471040
140TET1_21451524_ChIP-Seq_MESCs_Mouse0.97009496
141IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96932319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.56654091
2MP0002396_abnormal_hematopoietic_system2.96015283
3MP0005397_hematopoietic_system_phenotyp2.79423923
4MP0001545_abnormal_hematopoietic_system2.79423923
5MP0003436_decreased_susceptibility_to2.77858546
6MP0000685_abnormal_immune_system2.73992523
7MP0003724_increased_susceptibility_to2.66707199
8MP0009785_altered_susceptibility_to2.66385067
9MP0002132_abnormal_respiratory_system2.55021622
10MP0005025_abnormal_response_to2.41709395
11MP0005464_abnormal_platelet_physiology2.34075704
12MP0002419_abnormal_innate_immunity2.30201423
13MP0001800_abnormal_humoral_immune2.25458733
14MP0005671_abnormal_response_to2.24430538
15MP0005000_abnormal_immune_tolerance2.24061465
16MP0002148_abnormal_hypersensitivity_rea2.19223655
17MP0002452_abnormal_antigen_presenting2.18766303
18MP0003303_peritoneal_inflammation2.09234306
19MP0002420_abnormal_adaptive_immunity2.07036666
20MP0002723_abnormal_immune_serum2.06900187
21MP0001853_heart_inflammation2.06854234
22MP0001790_abnormal_immune_system2.05808749
23MP0005387_immune_system_phenotype2.05808749
24MP0001819_abnormal_immune_cell2.04639815
25MP0009278_abnormal_bone_marrow2.03362830
26MP0004808_abnormal_hematopoietic_stem2.01585990
27MP0003191_abnormal_cellular_cholesterol1.96421382
28MP0003763_abnormal_thymus_physiology1.95138397
29MP0002398_abnormal_bone_marrow1.89640559
30MP0002138_abnormal_hepatobiliary_system1.84652010
31MP0005058_abnormal_lysosome_morphology1.83050088
32MP0002166_altered_tumor_susceptibility1.82334158
33MP0000716_abnormal_immune_system1.76369007
34MP0001873_stomach_inflammation1.72638859
35MP0000689_abnormal_spleen_morphology1.71827723
36MP0002405_respiratory_system_inflammati1.71637132
37MP0000465_gastrointestinal_hemorrhage1.71577713
38MP0001845_abnormal_inflammatory_respons1.68557534
39MP0002429_abnormal_blood_cell1.59835580
40MP0000858_altered_metastatic_potential1.58773018
41MP0002722_abnormal_immune_system1.56711274
42MP0008438_abnormal_cutaneous_collagen1.55484089
43MP0006054_spinal_hemorrhage1.53661331
44MP0009840_abnormal_foam_cell1.52138137
45MP0003300_gastrointestinal_ulcer1.51796427
46MP0008004_abnormal_stomach_pH1.49625065
47MP0002877_abnormal_melanocyte_morpholog1.47646659
48MP0005174_abnormal_tail_pigmentation1.47506246
49MP0001533_abnormal_skeleton_physiology1.47406032
50MP0010155_abnormal_intestine_physiology1.46620549
51MP0008469_abnormal_protein_level1.46510181
52MP0000343_altered_response_to1.41225489
53MP0000490_abnormal_crypts_of1.37653094
54MP0010368_abnormal_lymphatic_system1.33963744
55MP0001986_abnormal_taste_sensitivity1.33895943
56MP0009333_abnormal_splenocyte_physiolog1.33379513
57MP0005075_abnormal_melanosome_morpholog1.33128998
58MP0003186_abnormal_redox_activity1.33047556
59MP0003656_abnormal_erythrocyte_physiolo1.26722678
60MP0005084_abnormal_gallbladder_morpholo1.24098179
61MP0002139_abnormal_hepatobiliary_system1.23383577
62MP0003195_calcinosis1.22580438
63MP0005365_abnormal_bile_salt1.21558782
64MP0006082_CNS_inflammation1.21431445
65MP0008260_abnormal_autophagy1.20795001
66MP0003172_abnormal_lysosome_physiology1.18594598
67MP0002006_tumorigenesis1.18432450
68MP0002933_joint_inflammation1.16073952
69MP0000015_abnormal_ear_pigmentation1.15509439
70MP0009764_decreased_sensitivity_to1.14881739
71MP0005220_abnormal_exocrine_pancreas1.10170395
72MP0000703_abnormal_thymus_morphology1.09957448
73MP0009379_abnormal_foot_pigmentation1.09676726
74MP0003866_abnormal_defecation1.05654791
75MP0003566_abnormal_cell_adhesion1.04720466
76MP0009763_increased_sensitivity_to1.04460018
77MP0003828_pulmonary_edema1.04388843
78MP0004947_skin_inflammation1.03873051
79MP0005390_skeleton_phenotype1.03758776
80MP0002998_abnormal_bone_remodeling1.03284221
81MP0010386_abnormal_urinary_bladder1.02665426
82MP0001879_abnormal_lymphatic_vessel1.01327160
83MP0001851_eye_inflammation1.00519251
84MP0003806_abnormal_nucleotide_metabolis0.98725034
85MP0000681_abnormal_thyroid_gland0.98634329
86MP0006036_abnormal_mitochondrial_physio0.97573391
87MP0005164_abnormal_response_to0.97565145
88MP0002019_abnormal_tumor_incidence0.97501586
89MP0005319_abnormal_enzyme/_coenzyme0.97461430
90MP0001764_abnormal_homeostasis0.97098350
91MP0003075_altered_response_to0.95257262
92MP0005165_increased_susceptibility_to0.95172293
93MP0000598_abnormal_liver_morphology0.94508679
94MP0004883_abnormal_blood_vessel0.93452250
95MP0005410_abnormal_fertilization0.92364173
96MP0005083_abnormal_biliary_tract0.90717912
97MP0003183_abnormal_peptide_metabolism0.90658428
98MP0002693_abnormal_pancreas_physiology0.90265866
99MP0000609_abnormal_liver_physiology0.89848300
100MP0005166_decreased_susceptibility_to0.89539697
101MP0005584_abnormal_enzyme/coenzyme_acti0.89324600
102MP0010329_abnormal_lipoprotein_level0.86244370
103MP0009643_abnormal_urine_homeostasis0.85831009
104MP0008007_abnormal_cellular_replicative0.85368939
105MP0003943_abnormal_hepatobiliary_system0.84536664
106MP0005310_abnormal_salivary_gland0.83663615
107MP0005367_renal/urinary_system_phenotyp0.83651027
108MP0000516_abnormal_urinary_system0.83651027
109MP0008875_abnormal_xenobiotic_pharmacok0.83212883
110MP0004147_increased_porphyrin_level0.83019577
111MP0001661_extended_life_span0.82879017
112MP0000604_amyloidosis0.82877382
113MP0005085_abnormal_gallbladder_physiolo0.80904533
114MP0002095_abnormal_skin_pigmentation0.80712703
115MP0005332_abnormal_amino_acid0.80653290
116MP0001663_abnormal_digestive_system0.79908220
117MP0003252_abnormal_bile_duct0.79886328
118MP0000249_abnormal_blood_vessel0.79541790
119MP0001756_abnormal_urination0.78799295
120MP0001348_abnormal_lacrimal_gland0.78610376
121MP0004510_myositis0.78352004
122MP0002928_abnormal_bile_duct0.76882178
123MP0002118_abnormal_lipid_homeostasis0.76867671
124MP0003279_aneurysm0.76571618
125MP0003795_abnormal_bone_structure0.75559150
126MP0010352_gastrointestinal_tract_polyps0.72289723
127MP0005360_urolithiasis0.68301581

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)5.17592435
2Abnormality of liposaccharide metabolism (HP:0010968)4.44286486
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.44286486
4Abnormality of glycolipid metabolism (HP:0010969)4.44286486
5Chronic otitis media (HP:0000389)4.30009655
6Abnormality of the nasal mucosa (HP:0000433)3.91581059
7Elevated erythrocyte sedimentation rate (HP:0003565)3.85011016
8Recurrent abscess formation (HP:0002722)3.77735474
9IgM deficiency (HP:0002850)3.76681519
10Eczematoid dermatitis (HP:0000976)3.70187794
11Recurrent bacterial skin infections (HP:0005406)3.66287354
12Spontaneous hematomas (HP:0007420)3.52336377
13Nasal polyposis (HP:0100582)3.45967243
14Petechiae (HP:0000967)3.36398310
15Reduced antithrombin III activity (HP:0001976)3.34743746
16Abnormality of cells of the erythroid lineage (HP:0012130)3.28010523
17Abnormal number of erythroid precursors (HP:0012131)3.27932574
18Type I transferrin isoform profile (HP:0003642)3.09834373
19Myositis (HP:0100614)3.04955913
20Recurrent gram-negative bacterial infections (HP:0005420)3.04685304
21Orchitis (HP:0100796)3.04454796
22Abnormal protein glycosylation (HP:0012346)3.01802120
23Abnormal glycosylation (HP:0012345)3.01802120
24Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.01802120
25Abnormal protein N-linked glycosylation (HP:0012347)3.01802120
26Aplastic anemia (HP:0001915)2.99704777
27Vacuolated lymphocytes (HP:0001922)2.99692942
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.97303092
29Generalized aminoaciduria (HP:0002909)2.86453863
30Increased neuronal autofluorescent lipopigment (HP:0002074)2.82829987
31Epistaxis (HP:0000421)2.80972870
32Abnormal platelet function (HP:0011869)2.80431475
33Impaired platelet aggregation (HP:0003540)2.80431475
34Abnormality of T cell physiology (HP:0011840)2.80280735
35Recurrent bronchitis (HP:0002837)2.79318356
36Prolonged bleeding time (HP:0003010)2.74986796
37Mucopolysacchariduria (HP:0008155)2.71532835
38Urinary glycosaminoglycan excretion (HP:0003541)2.71532835
39Abnormality of macrophages (HP:0004311)2.66718540
40Recurrent fungal infections (HP:0002841)2.66167767
41Cellulitis (HP:0100658)2.65731511
42Stomatitis (HP:0010280)2.62602471
43Recurrent skin infections (HP:0001581)2.61281090
44Increased cerebral lipofuscin (HP:0011813)2.61007814
45Loss of speech (HP:0002371)2.59111666
46Complement deficiency (HP:0004431)2.58873381
47Reticulocytopenia (HP:0001896)2.56296595
48Poor head control (HP:0002421)2.54654353
49Interstitial pulmonary disease (HP:0006530)2.52896536
50Recurrent viral infections (HP:0004429)2.52266148
51Mediastinal lymphadenopathy (HP:0100721)2.51443944
52Peritonitis (HP:0002586)2.48645073
53Meningitis (HP:0001287)2.47727272
54Cervical subluxation (HP:0003308)2.46807664
55Gastrointestinal inflammation (HP:0004386)2.46035825
56Pulmonary embolism (HP:0002204)2.44889111
57Amyloidosis (HP:0011034)2.43556722
58Abnormality of complement system (HP:0005339)2.42043140
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.41616400
60Abnormality of polysaccharide metabolism (HP:0011012)2.41616400
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.41616400
62Optic neuritis (HP:0100653)2.41059467
63Retrobulbar optic neuritis (HP:0100654)2.41059467
64Dysostosis multiplex (HP:0000943)2.39085804
65Microcytic anemia (HP:0001935)2.37074186
66Abnormality of iron homeostasis (HP:0011031)2.36320184
67Autoimmune thrombocytopenia (HP:0001973)2.35278784
68Chronic obstructive pulmonary disease (HP:0006510)2.33493812
69Obstructive lung disease (HP:0006536)2.33493812
70Hepatosplenomegaly (HP:0001433)2.32658153
71Chronic sinusitis (HP:0011109)2.32442863
72Chronic mucocutaneous candidiasis (HP:0002728)2.32373683
73Recurrent cutaneous fungal infections (HP:0011370)2.32373683
74Episodic fever (HP:0001954)2.31024050
75Prolonged neonatal jaundice (HP:0006579)2.30955467
76Hypoglycemic coma (HP:0001325)2.29517393
77Purpura (HP:0000979)2.29069849
78Arterial thrombosis (HP:0004420)2.28491726
79Colitis (HP:0002583)2.26998505
80Hematochezia (HP:0002573)2.26233904
81Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.22830903
82Microretrognathia (HP:0000308)2.21684078
83Gingival bleeding (HP:0000225)2.21532977
84Agammaglobulinemia (HP:0004432)2.18794729
85Decreased electroretinogram (ERG) amplitude (HP:0000654)2.18552903
86Inflammation of the large intestine (HP:0002037)2.16426693
87Abnormality of the heme biosynthetic pathway (HP:0010472)2.14770282
88Pulmonary infiltrates (HP:0002113)2.14411952
89Granulocytopenia (HP:0001913)2.13425881
90Hypochromic anemia (HP:0001931)2.13043628
91Myocardial infarction (HP:0001658)2.12501612
92Abnormality of T cells (HP:0002843)2.10824075
93Deep venous thrombosis (HP:0002625)2.10700635
94Exertional dyspnea (HP:0002875)2.10418803
95Increased muscle lipid content (HP:0009058)2.09389489
96Abnormality of transition element cation homeostasis (HP:0011030)2.08776441
97Hepatic necrosis (HP:0002605)2.07940641
98Systemic lupus erythematosus (HP:0002725)2.06241165
99Gastrointestinal infarctions (HP:0005244)2.05506431
100Polycythemia (HP:0001901)2.04758462
101Ovoid vertebral bodies (HP:0003300)2.04700855
102Spondylolisthesis (HP:0003302)2.04211354
103Hemoptysis (HP:0002105)2.03772048
104Vertebral compression fractures (HP:0002953)2.03669012
105Polygenic inheritance (HP:0010982)2.02947252
106Gastrointestinal stroma tumor (HP:0100723)2.02107222
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01768699
108Fatigue (HP:0012378)2.01621292
109Protrusio acetabuli (HP:0003179)2.00178714
110Chest pain (HP:0100749)2.00135765
111Thrombophlebitis (HP:0004418)1.99181180
112Periodontitis (HP:0000704)1.98283729
113Vasculitis (HP:0002633)1.97673357
114Abnormality of cells of the lymphoid lineage (HP:0012140)1.97598297
115Rectal prolapse (HP:0002035)1.97527903
116Abnormality of fatty-acid metabolism (HP:0004359)1.97369227
117Lymphopenia (HP:0001888)1.97223855
118Joint stiffness (HP:0001387)1.97169786
119Acute hepatic failure (HP:0006554)1.96672781
120Abnormality of aromatic amino acid family metabolism (HP:0004338)1.96396456
121Thoracic kyphosis (HP:0002942)1.95711172
122Urticaria (HP:0001025)1.95544167
123Increased intramyocellular lipid droplets (HP:0012240)1.93752686
124Hypertensive crisis (HP:0100735)1.92894468
125Progressive neurologic deterioration (HP:0002344)1.92853692
126Glomerulonephritis (HP:0000099)1.92149551
127Panhypogammaglobulinemia (HP:0003139)1.91930409
128Encephalitis (HP:0002383)1.91427256
129Hypergammaglobulinemia (HP:0010702)1.91227602
130Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90970373
131Gingivitis (HP:0000230)1.90180722
132Menorrhagia (HP:0000132)1.89646683
133Abnormality of the common coagulation pathway (HP:0010990)1.89204740
134Osteomyelitis (HP:0002754)1.89087830
135Agnosia (HP:0010524)1.87896738
136Bruising susceptibility (HP:0000978)1.87309482
137Basal ganglia calcification (HP:0002135)1.87050902
138Increased serum ferritin (HP:0003281)1.86895290
139Bronchitis (HP:0012387)1.85955655
140Increased IgE level (HP:0003212)1.84270988
141Anorexia (HP:0002039)1.83950910
142Amaurosis fugax (HP:0100576)1.83890422
143Restrictive lung disease (HP:0002091)1.83607795
144Joint hemorrhage (HP:0005261)1.83332707
145Hypoplasia of the thymus (HP:0000778)1.83304060
146Abnormality of the lumbar spine (HP:0100712)1.82716618
147Abnormality of the thoracic spine (HP:0100711)1.82509567
148Recurrent lower respiratory tract infections (HP:0002783)1.82244457
149Hemorrhage of the eye (HP:0011885)1.80501358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT33.07776080
2ERN12.96405294
3KIT2.77271409
4MAP4K12.65832697
5NME22.57148215
6BTK2.33276738
7MAP3K32.29082911
8TAOK32.26032979
9TEC2.24852123
10BCKDK2.21027013
11TGFBR22.19461412
12PIM22.17818755
13SCYL22.15413020
14EEF2K2.12872039
15IRAK42.02298835
16IRAK31.99151236
17BLK1.98365421
18TBK11.97186379
19TNK21.95280112
20MAP2K31.95215055
21ZAP701.94721518
22KDR1.91124748
23JAK31.88750993
24TYK21.71258712
25TESK21.64018912
26TGFBR11.60459714
27PINK11.59656991
28STK161.54647404
29RPS6KA41.54532715
30LRRK21.51940956
31CSF1R1.51691800
32SYK1.37268429
33TIE11.36224571
34MATK1.34235461
35TRIB31.32935978
36ARAF1.32146135
37PASK1.31418372
38SIK31.30696831
39VRK11.29053881
40PRKD21.25556088
41RIPK41.24509043
42PKN21.23469493
43WEE11.22979376
44EIF2AK31.16666075
45IKBKE1.15944003
46MAP3K11.15235976
47CDK81.14362193
48STK101.14146291
49SIK11.10108110
50MAP3K101.08087849
51MAP3K141.07215091
52FES1.04586193
53IKBKB1.03470274
54PRPF4B1.00439506
55CDK190.98463917
56LYN0.96622722
57ACVR1B0.92924963
58LCK0.87958232
59EPHB10.87651965
60PIM10.85888824
61ITK0.83728219
62MAP3K70.83022312
63DDR20.82022317
64PRKCQ0.81469998
65RPS6KA60.79318791
66NLK0.78949768
67RPS6KB20.78356129
68FGFR40.78073320
69MAPKAPK30.76606585
70MAP2K60.76577885
71TNIK0.76340864
72HCK0.76264137
73PDPK10.76218827
74MAP3K130.76069156
75MAPK110.75503752
76GRK60.74299573
77TAOK20.73533266
78CSK0.73492043
79HIPK20.73010535
80TAOK10.72892549
81MAPKAPK50.69734891
82MAPK70.68297162
83DYRK30.68139023
84MYLK0.65792313
85IRAK10.65729379
86SMG10.65302547
87DAPK30.65221844
88MOS0.64967499
89CDK40.64696976
90PDK10.64437133
91ABL20.62939792
92TRPM70.62850076
93MAP3K110.61934155
94RPS6KC10.61934069
95RPS6KL10.61934069
96MAPK150.61509836
97PRKG20.61078800
98BRSK20.59415218
99ADRBK10.58394054
100FGFR30.56961756
101JAK10.55957557
102PTK2B0.55693570
103DAPK10.54889099
104JAK20.54782289
105MAPK120.51280181
106MAPK40.50808581
107RET0.50717823
108DYRK1B0.50570861
109TESK10.49885471
110ADRBK20.49446698
111PIK3CG0.49382609
112RIPK10.48999802
113MAPKAPK20.48208944
114GRK50.48130271
115SIK20.47317511
116CLK10.46829923
117RAF10.45137036
118FGR0.44734887
119EPHA30.44428615
120CDC42BPA0.43702594
121RPS6KA20.43690769
122PTK60.43541103
123MAP4K20.42989635
124PAK40.42837958
125ILK0.42123617
126CHUK0.41575264
127MAP3K80.41228866
128CAMKK20.40626673
129PRKCD0.40398711
130CDK90.40010400
131PRKD10.39786619
132MAP3K50.39326925
133TLK10.39313896
134MARK30.38822173
135GRK70.37935345
136MARK20.37786806
137FRK0.36543652
138MUSK0.36450234

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.65026054
2Ribosome_Homo sapiens_hsa030103.41933433
3Asthma_Homo sapiens_hsa053102.51760044
4Allograft rejection_Homo sapiens_hsa053302.47311165
5Other glycan degradation_Homo sapiens_hsa005112.43978865
6Mismatch repair_Homo sapiens_hsa034302.34476263
7Autoimmune thyroid disease_Homo sapiens_hsa053202.23737056
8Leishmaniasis_Homo sapiens_hsa051402.17460568
9Graft-versus-host disease_Homo sapiens_hsa053322.14662288
10Base excision repair_Homo sapiens_hsa034102.04642713
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.02483593
12B cell receptor signaling pathway_Homo sapiens_hsa046622.00535017
13Sulfur relay system_Homo sapiens_hsa041221.98728450
14Protein export_Homo sapiens_hsa030601.97004510
15Antigen processing and presentation_Homo sapiens_hsa046121.96144210
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.94725210
17Primary immunodeficiency_Homo sapiens_hsa053401.85268451
18Staphylococcus aureus infection_Homo sapiens_hsa051501.79316900
19Type I diabetes mellitus_Homo sapiens_hsa049401.74693342
20Folate biosynthesis_Homo sapiens_hsa007901.64181518
21N-Glycan biosynthesis_Homo sapiens_hsa005101.62207321
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.59296332
23Osteoclast differentiation_Homo sapiens_hsa043801.44770789
24Pyrimidine metabolism_Homo sapiens_hsa002401.40938619
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.40804849
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.36717234
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33865616
28Shigellosis_Homo sapiens_hsa051311.32670659
29Rheumatoid arthritis_Homo sapiens_hsa053231.32424588
30Phagosome_Homo sapiens_hsa041451.32060714
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31878630
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.31487867
33Measles_Homo sapiens_hsa051621.31324722
34Legionellosis_Homo sapiens_hsa051341.31239724
35Homologous recombination_Homo sapiens_hsa034401.30135306
36Herpes simplex infection_Homo sapiens_hsa051681.29895128
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29677747
38Arachidonic acid metabolism_Homo sapiens_hsa005901.28773647
39Chemical carcinogenesis_Homo sapiens_hsa052041.24646655
40Pentose phosphate pathway_Homo sapiens_hsa000301.24311714
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22366636
42Pertussis_Homo sapiens_hsa051331.20741346
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20400992
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18378261
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17496258
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17388521
47Nucleotide excision repair_Homo sapiens_hsa034201.15272951
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.12482183
49Acute myeloid leukemia_Homo sapiens_hsa052211.11906812
50Galactose metabolism_Homo sapiens_hsa000521.10892124
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10655578
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10009088
53Viral myocarditis_Homo sapiens_hsa054161.09827501
54Hematopoietic cell lineage_Homo sapiens_hsa046401.09467275
55Lysosome_Homo sapiens_hsa041421.09425331
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.06685237
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.02759374
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.01136158
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00300014
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.99230500
61Selenocompound metabolism_Homo sapiens_hsa004500.98888521
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97176060
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95839248
64Hepatitis B_Homo sapiens_hsa051610.93412882
65Apoptosis_Homo sapiens_hsa042100.91695812
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.90355919
67Proteasome_Homo sapiens_hsa030500.89717353
68Systemic lupus erythematosus_Homo sapiens_hsa053220.89155386
69Tyrosine metabolism_Homo sapiens_hsa003500.88301143
70Complement and coagulation cascades_Homo sapiens_hsa046100.87375970
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87230632
72Tuberculosis_Homo sapiens_hsa051520.86222761
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85797784
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85620286
75Glutathione metabolism_Homo sapiens_hsa004800.85330442
76Influenza A_Homo sapiens_hsa051640.85295315
77Platelet activation_Homo sapiens_hsa046110.84375384
78Peroxisome_Homo sapiens_hsa041460.81866491
79One carbon pool by folate_Homo sapiens_hsa006700.80962085
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80690292
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.80539504
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80232795
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79457051
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79307912
85Toxoplasmosis_Homo sapiens_hsa051450.78770737
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.75952396
87Malaria_Homo sapiens_hsa051440.75320916
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75110536
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72755744
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71801585
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71565208
92Spliceosome_Homo sapiens_hsa030400.71363459
93RNA polymerase_Homo sapiens_hsa030200.71122182
94Fructose and mannose metabolism_Homo sapiens_hsa000510.71096759
95Caffeine metabolism_Homo sapiens_hsa002320.69092547
96Fatty acid degradation_Homo sapiens_hsa000710.67508945
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67365632
98Tryptophan metabolism_Homo sapiens_hsa003800.67207369
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66065748
100TNF signaling pathway_Homo sapiens_hsa046680.64558976
101Retinol metabolism_Homo sapiens_hsa008300.63083480
102Sulfur metabolism_Homo sapiens_hsa009200.61167459
103ABC transporters_Homo sapiens_hsa020100.60297703
104beta-Alanine metabolism_Homo sapiens_hsa004100.59857857
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59479921
106Epstein-Barr virus infection_Homo sapiens_hsa051690.58546505
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57783343
108Starch and sucrose metabolism_Homo sapiens_hsa005000.57660067
109PPAR signaling pathway_Homo sapiens_hsa033200.57370684
110Amoebiasis_Homo sapiens_hsa051460.56486710
111RNA degradation_Homo sapiens_hsa030180.56344714
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56001807
113African trypanosomiasis_Homo sapiens_hsa051430.55532985
114Hepatitis C_Homo sapiens_hsa051600.55052582
115Chronic myeloid leukemia_Homo sapiens_hsa052200.53564275
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52583720
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51725609
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.51623950
119Purine metabolism_Homo sapiens_hsa002300.51317928
120Phenylalanine metabolism_Homo sapiens_hsa003600.48570013
121Chemokine signaling pathway_Homo sapiens_hsa040620.47456084
122Regulation of autophagy_Homo sapiens_hsa041400.46838136
123Non-homologous end-joining_Homo sapiens_hsa034500.46508099
124Sphingolipid metabolism_Homo sapiens_hsa006000.44634208
125Fatty acid elongation_Homo sapiens_hsa000620.44397025
126Fatty acid metabolism_Homo sapiens_hsa012120.44228734
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43618309
128Salmonella infection_Homo sapiens_hsa051320.43050822
129Thyroid cancer_Homo sapiens_hsa052160.42500712
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42469623
131Biosynthesis of amino acids_Homo sapiens_hsa012300.41629369
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41460215
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40310503
134Carbon metabolism_Homo sapiens_hsa012000.39504995
135Non-small cell lung cancer_Homo sapiens_hsa052230.39123948
136Collecting duct acid secretion_Homo sapiens_hsa049660.36793049
137Butanoate metabolism_Homo sapiens_hsa006500.35799451

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