ORAOV1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.20570959
2ribosomal large subunit biogenesis (GO:0042273)6.01414595
3translational termination (GO:0006415)5.90500430
4chaperone-mediated protein transport (GO:0072321)5.73757539
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.44399246
6cotranslational protein targeting to membrane (GO:0006613)5.32148108
7protein targeting to ER (GO:0045047)5.32075216
8ribosomal small subunit assembly (GO:0000028)5.10649410
9protein localization to endoplasmic reticulum (GO:0070972)5.07326372
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.04298729
11sphingoid metabolic process (GO:0046519)4.95791345
12metanephric mesenchyme development (GO:0072075)4.73356381
13sphingosine metabolic process (GO:0006670)4.69873097
14viral life cycle (GO:0019058)4.64777368
15translational elongation (GO:0006414)4.56415890
16cellular protein complex disassembly (GO:0043624)4.52166098
17negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.51921587
18kidney mesenchyme development (GO:0072074)4.45998171
19viral mRNA export from host cell nucleus (GO:0046784)4.43331995
20detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.42319587
21pattern specification involved in kidney development (GO:0061004)4.41491310
22attachment of spindle microtubules to kinetochore (GO:0008608)4.36888753
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.27807265
24translational initiation (GO:0006413)4.25690647
25diol metabolic process (GO:0034311)4.25459788
26tryptophan catabolic process (GO:0006569)4.16404499
27indole-containing compound catabolic process (GO:0042436)4.16404499
28indolalkylamine catabolic process (GO:0046218)4.16404499
29negative regulation of cell cycle G2/M phase transition (GO:1902750)4.15156316
30detection of light stimulus involved in sensory perception (GO:0050962)4.12583617
31detection of light stimulus involved in visual perception (GO:0050908)4.12583617
32negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)4.02006087
33protein complex disassembly (GO:0043241)3.98918010
34flavonoid metabolic process (GO:0009812)3.98709687
35ribosomal small subunit biogenesis (GO:0042274)3.95298182
36DNA methylation involved in gamete generation (GO:0043046)3.94453449
37positive regulation of developmental pigmentation (GO:0048087)3.93053150
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.92493541
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.92493541
40NADH dehydrogenase complex assembly (GO:0010257)3.92493541
41regulation of posttranscriptional gene silencing (GO:0060147)3.87487298
42regulation of gene silencing by miRNA (GO:0060964)3.87487298
43regulation of gene silencing by RNA (GO:0060966)3.87487298
44indolalkylamine metabolic process (GO:0006586)3.87054648
45regulation of development, heterochronic (GO:0040034)3.84255773
46macromolecular complex disassembly (GO:0032984)3.83613728
47protein K11-linked deubiquitination (GO:0035871)3.82099508
48kynurenine metabolic process (GO:0070189)3.81942122
49maturation of 5.8S rRNA (GO:0000460)3.80486649
50regulation of hippo signaling (GO:0035330)3.78203465
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.71225342
52protein complex biogenesis (GO:0070271)3.70667005
53DNA ligation (GO:0006266)3.67751072
54regulation of nuclear cell cycle DNA replication (GO:0033262)3.67016393
55mitochondrial respiratory chain complex assembly (GO:0033108)3.66142776
56behavioral response to nicotine (GO:0035095)3.65119657
57paraxial mesoderm development (GO:0048339)3.64110196
58middle ear morphogenesis (GO:0042474)3.61830133
59protein targeting to membrane (GO:0006612)3.59489289
60pseudouridine synthesis (GO:0001522)3.58894859
61transcription elongation from RNA polymerase III promoter (GO:0006385)3.57459084
62termination of RNA polymerase III transcription (GO:0006386)3.57459084
63mesenchymal cell differentiation involved in kidney development (GO:0072161)3.53691954
64mesenchymal cell differentiation involved in renal system development (GO:2001012)3.53691954
65regulation of pigment cell differentiation (GO:0050932)3.50810697
66maturation of SSU-rRNA (GO:0030490)3.49550712
67myoblast migration (GO:0051451)3.40771156
68neural tube formation (GO:0001841)3.40340902
69tooth mineralization (GO:0034505)3.39713667
70left/right axis specification (GO:0070986)3.39137697
71translation (GO:0006412)3.36699017
72cranial nerve morphogenesis (GO:0021602)3.35550899
73tryptophan metabolic process (GO:0006568)3.32257415
74response to misfolded protein (GO:0051788)3.30684029
75piRNA metabolic process (GO:0034587)3.30562403
76cellular biogenic amine catabolic process (GO:0042402)3.28936594
77amine catabolic process (GO:0009310)3.28936594
78negative regulation of epidermal cell differentiation (GO:0045605)3.27141065
79ncRNA 3-end processing (GO:0043628)3.25869773
80protein neddylation (GO:0045116)3.25087523
81regulation of heart morphogenesis (GO:2000826)3.24984518
82tachykinin receptor signaling pathway (GO:0007217)3.24001104
83regulation of secondary heart field cardioblast proliferation (GO:0003266)3.19539198
84regulation of cardioblast proliferation (GO:0003264)3.19539198
85sulfate transmembrane transport (GO:1902358)3.18929452
86positive regulation of gastrulation (GO:2000543)3.18656161
87detection of chemical stimulus involved in sensory perception (GO:0050907)3.18246758
88negative regulation of keratinocyte proliferation (GO:0010839)3.13750261
89pyrimidine dimer repair (GO:0006290)3.12766468
90neural crest cell development (GO:0014032)3.11963059
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.10263649
92short-term memory (GO:0007614)3.10031715
93reflex (GO:0060004)3.09736516
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09604042
95sulfate transport (GO:0008272)3.09023571
96negative regulation of epidermis development (GO:0045683)3.06940016
97ATP synthesis coupled proton transport (GO:0015986)3.06304099
98energy coupled proton transport, down electrochemical gradient (GO:0015985)3.06304099
99cilium or flagellum-dependent cell motility (GO:0001539)3.00916544
100nuclear-transcribed mRNA catabolic process (GO:0000956)3.00263848
101regulation of mitochondrial translation (GO:0070129)2.99746987
102GTP biosynthetic process (GO:0006183)2.99589139
103seminiferous tubule development (GO:0072520)2.97891459
104cardiovascular system development (GO:0072358)2.96875607
105heterochromatin organization (GO:0070828)2.95587561
106establishment of mitotic spindle orientation (GO:0000132)2.95374274
107regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.95213021
108heart valve formation (GO:0003188)2.94623834
109endocardial cushion morphogenesis (GO:0003203)2.94396236
110regulation of keratinocyte proliferation (GO:0010837)2.93916787
111NAD biosynthetic process (GO:0009435)2.92622272
112regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.92439646
113regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.92439646
114transcription-coupled nucleotide-excision repair (GO:0006283)2.92301657
115spliceosomal complex assembly (GO:0000245)2.91717313
116signal peptide processing (GO:0006465)2.91648800
117DNA catabolic process, exonucleolytic (GO:0000738)2.91196881
118mesenchyme morphogenesis (GO:0072132)2.90936630
119regulation of mesonephros development (GO:0061217)2.90853102
120regulation of meiosis I (GO:0060631)2.89559201
121regulation of somitogenesis (GO:0014807)2.87183817
122mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.86500467
123regulation of mesoderm development (GO:2000380)2.86257251
124behavioral response to ethanol (GO:0048149)2.85903261
125cell differentiation involved in metanephros development (GO:0072202)2.85484362
126auditory receptor cell stereocilium organization (GO:0060088)2.85152281
127pituitary gland development (GO:0021983)2.83776204
128mRNA catabolic process (GO:0006402)2.83226481
129regulation of mesenchymal cell apoptotic process (GO:2001053)2.83203564
130photoreceptor cell maintenance (GO:0045494)2.82939248
131aromatic amino acid family catabolic process (GO:0009074)2.81737711
132mesenchymal cell proliferation (GO:0010463)2.81537962
133mesenchymal cell development (GO:0014031)2.79839412
134regulation of glomerulus development (GO:0090192)2.79062081
135tRNA processing (GO:0008033)2.78627520
136proteasome assembly (GO:0043248)2.77722925
137lymph vessel development (GO:0001945)2.76709551
138phosphatidylinositol acyl-chain remodeling (GO:0036149)2.76627370
139sympathetic nervous system development (GO:0048485)2.75839496
140regulation of rhodopsin mediated signaling pathway (GO:0022400)2.74934068
141L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.74679776
142righting reflex (GO:0060013)2.73383330
143embryonic cranial skeleton morphogenesis (GO:0048701)2.73092810
144nephron tubule formation (GO:0072079)2.73002460
145negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.72324210
146centriole replication (GO:0007099)2.72041839
147regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.71249842
148transcription from mitochondrial promoter (GO:0006390)2.71151228
149DNA damage response, detection of DNA damage (GO:0042769)2.70844170
150positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.70668041
151outer ear morphogenesis (GO:0042473)2.70011710
152establishment of spindle orientation (GO:0051294)2.69709507
153artery development (GO:0060840)2.69617358
154positive regulation of mesonephros development (GO:0061213)2.68984087
155neuron fate specification (GO:0048665)2.67771965
156snRNA transcription (GO:0009301)2.67078230
157positive regulation of mitochondrial fission (GO:0090141)2.66516001
158spliceosomal snRNP assembly (GO:0000387)2.66119544
159opioid receptor signaling pathway (GO:0038003)2.65459183
160developmental induction (GO:0031128)2.65114575
161mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.64975972
1627-methylguanosine mRNA capping (GO:0006370)2.64419402
163positive regulation of embryonic development (GO:0040019)2.63961478
164protein K11-linked ubiquitination (GO:0070979)2.62618229
165regulation of mitochondrial fission (GO:0090140)2.62458315
166regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.62196289
167negative regulation of translational initiation (GO:0045947)2.61663440
168mannosylation (GO:0097502)2.61486230
169cellular response to ATP (GO:0071318)2.60434290
170cell-cell signaling involved in cell fate commitment (GO:0045168)2.59664933
171cell proliferation involved in kidney development (GO:0072111)2.59136493
172nephron epithelium morphogenesis (GO:0072088)2.59073385
173nephron tubule morphogenesis (GO:0072078)2.59073385
174cell migration involved in heart development (GO:0060973)2.57877828
175establishment of mitotic spindle localization (GO:0040001)2.54619010
176RNA capping (GO:0036260)2.54458702
1777-methylguanosine RNA capping (GO:0009452)2.54458702
178negative regulation of kidney development (GO:0090185)2.54168700
179kinetochore assembly (GO:0051382)2.54123368
180mesonephros development (GO:0001823)2.54089287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse7.18380775
2E2F7_22180533_ChIP-Seq_HELA_Human5.16533809
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.58132135
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.22477502
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.99864886
6VDR_22108803_ChIP-Seq_LS180_Human3.78889946
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.78037767
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.68377271
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.10187248
10RBPJ_22232070_ChIP-Seq_NCS_Mouse3.09058057
11ZNF274_21170338_ChIP-Seq_K562_Hela3.06030739
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.03550250
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.82836236
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.67476147
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.62670333
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.50113931
17* ETS1_20019798_ChIP-Seq_JURKAT_Human2.49993161
18ELK1_22589737_ChIP-Seq_MCF10A_Human2.46734041
19AR_21572438_ChIP-Seq_LNCaP_Human2.46231349
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.40349123
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37839099
22EZH2_22144423_ChIP-Seq_EOC_Human2.31387620
23GBX2_23144817_ChIP-Seq_PC3_Human2.25261919
24KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.20356510
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19952288
26DCP1A_22483619_ChIP-Seq_HELA_Human2.17580826
27ELK1_19687146_ChIP-ChIP_HELA_Human2.14101913
28* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13289777
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12293866
30CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09615190
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.03549069
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.03176691
33ER_23166858_ChIP-Seq_MCF-7_Human2.01588798
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01247761
35TP53_16413492_ChIP-PET_HCT116_Human1.99644013
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.95631933
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92867171
38XRN2_22483619_ChIP-Seq_HELA_Human1.92852987
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.92817517
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89923822
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86832933
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.86039832
43TP53_20018659_ChIP-ChIP_R1E_Mouse1.83084950
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79893149
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77233901
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.77233901
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75176785
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.74587562
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74242037
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71788855
51TTF2_22483619_ChIP-Seq_HELA_Human1.71648317
52TAF15_26573619_Chip-Seq_HEK293_Human1.66729330
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62443530
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60948045
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.57675687
56KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.57675687
57KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.57675687
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57096057
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55908105
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.54883167
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.54108344
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.53582113
63FUS_26573619_Chip-Seq_HEK293_Human1.53076463
64MYC_18940864_ChIP-ChIP_HL60_Human1.52595771
65IGF1R_20145208_ChIP-Seq_DFB_Human1.51204866
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50354245
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.41034671
68STAT3_23295773_ChIP-Seq_U87_Human1.40209726
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.39639623
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38510872
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38080571
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.37905620
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35306434
74P300_19829295_ChIP-Seq_ESCs_Human1.32822234
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32324603
76TDRD3_21172665_ChIP-Seq_MCF-7_Human1.31863854
77HOXB7_26014856_ChIP-Seq_BT474_Human1.28783146
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28199299
79TP63_17297297_ChIP-ChIP_HaCaT_Human1.28141994
80* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27466382
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26337328
82NANOG_19829295_ChIP-Seq_ESCs_Human1.26013190
83SOX2_19829295_ChIP-Seq_ESCs_Human1.26013190
84BCAT_22108803_ChIP-Seq_LS180_Human1.23940907
85ERA_21632823_ChIP-Seq_H3396_Human1.23861743
86AR_21909140_ChIP-Seq_LNCAP_Human1.23175565
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22753873
88* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22513334
89FOXA1_25329375_ChIP-Seq_VCAP_Human1.22319958
90FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22319958
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22290029
92EZH2_27304074_Chip-Seq_ESCs_Mouse1.21630839
93P53_21459846_ChIP-Seq_SAOS-2_Human1.20326715
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20038025
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19970578
96MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.19282621
97CBP_20019798_ChIP-Seq_JUKART_Human1.17960247
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17960247
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.17697548
100TP53_22573176_ChIP-Seq_HFKS_Human1.17370938
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16672457
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16231902
103NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16222841
104NANOG_16153702_ChIP-ChIP_HESCs_Human1.15984535
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14957018
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14868444
107* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14533171
108NOTCH1_21737748_ChIP-Seq_TLL_Human1.14196695
109TCF4_22108803_ChIP-Seq_LS180_Human1.14196559
110* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13436066
111SOX17_20123909_ChIP-Seq_XEN_Mouse1.11168156
112MYC_19829295_ChIP-Seq_ESCs_Human1.10888231
113NANOG_20526341_ChIP-Seq_ESCs_Human1.09727749
114PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09427806
115EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09416911
116TCF4_23295773_ChIP-Seq_U87_Human1.08917323
117DROSHA_22980978_ChIP-Seq_HELA_Human1.07852343
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07851157
119STAT1_20625510_ChIP-Seq_HELA_Human1.07836872
120* NCOR_22424771_ChIP-Seq_293T_Human1.06859814
121E2F1_21310950_ChIP-Seq_MCF-7_Human1.06760623
122HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06368782
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05093753
124VDR_23849224_ChIP-Seq_CD4+_Human1.04897389
125YY1_22570637_ChIP-Seq_MALME-3M_Human1.03133868
126AR_25329375_ChIP-Seq_VCAP_Human1.03023051
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02633842
128FOXP3_21729870_ChIP-Seq_TREG_Human1.01521043
129RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01209823
130ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00436430
131SOX2_20726797_ChIP-Seq_SW620_Human1.00100711
132OCT4_20526341_ChIP-Seq_ESCs_Human0.99561099
133EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98858865
134SMAD4_21741376_ChIP-Seq_EPCs_Human0.98344143
135IRF1_19129219_ChIP-ChIP_H3396_Human0.98223718
136* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97453227
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96687320
138AR_20517297_ChIP-Seq_VCAP_Human0.96612357
139STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96240146
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94614149
141REST_21632747_ChIP-Seq_MESCs_Mouse0.94033851
142WDR5_24793694_ChIP-Seq_LNCAP_Human0.93960348
143VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93446287
144POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93283117
145KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93115281
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92972321
147SMAD3_21741376_ChIP-Seq_EPCs_Human0.92238690
148EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91917313
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.91648545
150* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91055194
151EWS_26573619_Chip-Seq_HEK293_Human0.90653151
152PRDM14_20953172_ChIP-Seq_ESCs_Human0.88739488
153RNF2_27304074_Chip-Seq_NSC_Mouse0.88609243
154SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88178976
155* GABP_19822575_ChIP-Seq_HepG2_Human0.88150832
156CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88051649
157CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87937784
158OCT1_27270436_Chip-Seq_PROSTATE_Human0.87544999
159LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86812961
160SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86507860
161* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84972807
162TP53_18474530_ChIP-ChIP_U2OS_Human0.83928893
163EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83275202
164SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81527406
165SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81527406
166EZH2_18974828_ChIP-Seq_MESCs_Mouse0.79567956
167RNF2_18974828_ChIP-Seq_MESCs_Mouse0.79567956
168SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.78961990
169SOX2_16153702_ChIP-ChIP_HESCs_Human0.78868319
170SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77928424
171JARID2_20075857_ChIP-Seq_MESCs_Mouse0.77635790
172CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.76891181
173SMC3_22415368_ChIP-Seq_MEFs_Mouse0.75848137
174PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74781768
175FOXM1_23109430_ChIP-Seq_U2OS_Human0.74340329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.07787987
2MP0010030_abnormal_orbit_morphology4.60254272
3MP0002837_dystrophic_cardiac_calcinosis4.26250531
4MP0005084_abnormal_gallbladder_morpholo4.10735702
5MP0002653_abnormal_ependyma_morphology4.08398275
6MP0000566_synostosis3.65966395
7MP0003941_abnormal_skin_development3.31108326
8MP0001346_abnormal_lacrimal_gland3.23313230
9MP0005171_absent_coat_pigmentation3.02854154
10MP0006292_abnormal_olfactory_placode2.96550572
11MP0008961_abnormal_basal_metabolism2.88420842
12MP0002928_abnormal_bile_duct2.77540235
13MP0000049_abnormal_middle_ear2.72963237
14MP0003646_muscle_fatigue2.66002538
15MP0005257_abnormal_intraocular_pressure2.58219142
16MP0009250_abnormal_appendicular_skeleto2.37387149
17MP0009053_abnormal_anal_canal2.35211457
18MP0002277_abnormal_respiratory_mucosa2.34001367
19MP0003136_yellow_coat_color2.31347200
20MP0005409_darkened_coat_color2.26427733
21MP0003252_abnormal_bile_duct2.25538558
22MP0003385_abnormal_body_wall2.24806085
23MP0003315_abnormal_perineum_morphology2.24493825
24MP0000569_abnormal_digit_pigmentation2.19896348
25MP0005503_abnormal_tendon_morphology2.11922555
26MP0008789_abnormal_olfactory_epithelium2.09438438
27MP0002249_abnormal_larynx_morphology1.99784699
28MP0003878_abnormal_ear_physiology1.96018454
29MP0005377_hearing/vestibular/ear_phenot1.96018454
30MP0001968_abnormal_touch/_nociception1.95798067
31MP0003942_abnormal_urinary_system1.95479565
32MP0003045_fibrosis1.94698957
33MP0005174_abnormal_tail_pigmentation1.92911384
34MP0000678_abnormal_parathyroid_gland1.92487189
35MP0005670_abnormal_white_adipose1.89455233
36MP0002736_abnormal_nociception_after1.88816921
37MP0002282_abnormal_trachea_morphology1.85755745
38MP0009697_abnormal_copulation1.82194000
39MP0002163_abnormal_gland_morphology1.82083608
40MP0004043_abnormal_pH_regulation1.80264652
41MP0002138_abnormal_hepatobiliary_system1.78381289
42MP0005551_abnormal_eye_electrophysiolog1.76705670
43MP0001188_hyperpigmentation1.73430878
44MP0003879_abnormal_hair_cell1.73364515
45MP0004272_abnormal_basement_membrane1.70342056
46MP0000428_abnormal_craniofacial_morphol1.69664165
47MP0005367_renal/urinary_system_phenotyp1.65040360
48MP0000516_abnormal_urinary_system1.65040360
49MP0002177_abnormal_outer_ear1.64925649
50MP0003195_calcinosis1.64799395
51MP0000762_abnormal_tongue_morphology1.63188985
52MP0003938_abnormal_ear_development1.62845958
53MP0008932_abnormal_embryonic_tissue1.60243285
54MP0008438_abnormal_cutaneous_collagen1.57310111
55MP0000613_abnormal_salivary_gland1.52578567
56MP0002098_abnormal_vibrissa_morphology1.52129063
57MP0002938_white_spotting1.51259051
58MP0003755_abnormal_palate_morphology1.50264498
59MP0001286_abnormal_eye_development1.49364521
60MP0004130_abnormal_muscle_cell1.48507708
61MP0002638_abnormal_pupillary_reflex1.43187753
62MP0009046_muscle_twitch1.41542662
63MP0002160_abnormal_reproductive_system1.39729101
64MP0000681_abnormal_thyroid_gland1.39649487
65MP0005379_endocrine/exocrine_gland_phen1.37437382
66MP0003937_abnormal_limbs/digits/tail_de1.37279889
67MP0003806_abnormal_nucleotide_metabolis1.35268784
68MP0000427_abnormal_hair_cycle1.35119155
69MP0006072_abnormal_retinal_apoptosis1.33548308
70MP0003123_paternal_imprinting1.33449357
71MP0008057_abnormal_DNA_replication1.31116918
72MP0008872_abnormal_physiological_respon1.29425733
73MP0001485_abnormal_pinna_reflex1.28737186
74MP0003115_abnormal_respiratory_system1.28684653
75MP0001501_abnormal_sleep_pattern1.25231309
76MP0002233_abnormal_nose_morphology1.24662036
77MP0001958_emphysema1.23200948
78MP0001270_distended_abdomen1.22354074
79MP0009384_cardiac_valve_regurgitation1.19988633
80MP0008875_abnormal_xenobiotic_pharmacok1.17504346
81MP0005085_abnormal_gallbladder_physiolo1.16875452
82MP0001986_abnormal_taste_sensitivity1.16800178
83MP0004142_abnormal_muscle_tone1.15266034
84MP0002932_abnormal_joint_morphology1.13692600
85MP0002009_preneoplasia1.13679262
86MP0004381_abnormal_hair_follicle1.13235098
87MP0004147_increased_porphyrin_level1.12200693
88MP0005508_abnormal_skeleton_morphology1.12171090
89MP0005197_abnormal_uvea_morphology1.11563245
90MP0002751_abnormal_autonomic_nervous1.09141179
91MP0002116_abnormal_craniofacial_bone1.08614645
92MP0008007_abnormal_cellular_replicative1.08448951
93MP0009745_abnormal_behavioral_response1.08367838
94MP0000163_abnormal_cartilage_morphology1.05314232
95MP0001299_abnormal_eye_distance/1.05234150
96MP0002168_other_aberrant_phenotype1.04348642
97MP0008058_abnormal_DNA_repair1.04132783
98MP0000467_abnormal_esophagus_morphology1.03795201
99MP0000631_abnormal_neuroendocrine_gland1.03666117
100MP0005646_abnormal_pituitary_gland1.03404181
101MP0001486_abnormal_startle_reflex1.03186383
102MP0002735_abnormal_chemical_nociception1.02527887
103MP0003011_delayed_dark_adaptation1.02120854
104MP0000733_abnormal_muscle_development1.01872542
105MP0003943_abnormal_hepatobiliary_system1.01176620
106MP0003935_abnormal_craniofacial_develop0.99356821
107MP0001879_abnormal_lymphatic_vessel0.98518033
108MP0003890_abnormal_embryonic-extraembry0.98166389
109MP0002109_abnormal_limb_morphology0.97414406
110MP0005448_abnormal_energy_balance0.96747417
111MP0003119_abnormal_digestive_system0.96265407
112MP0005253_abnormal_eye_physiology0.95689462
113MP0000372_irregular_coat_pigmentation0.95395588
114MP0005389_reproductive_system_phenotype0.94321595
115MP0009764_decreased_sensitivity_to0.94178425
116MP0001905_abnormal_dopamine_level0.93851637
117MP0001919_abnormal_reproductive_system0.93228194
118MP0002876_abnormal_thyroid_physiology0.92963714
119MP0003122_maternal_imprinting0.91750647
120MP0000538_abnormal_urinary_bladder0.91460240
121MP0001177_atelectasis0.91447798
122MP0002111_abnormal_tail_morphology0.90963443
123MP0000767_abnormal_smooth_muscle0.89687319
124MP0003718_maternal_effect0.89560525
125MP0002102_abnormal_ear_morphology0.88985844
126MP0002572_abnormal_emotion/affect_behav0.88785852
127MP0000432_abnormal_head_morphology0.87795625
128MP0005248_abnormal_Harderian_gland0.86966615
129MP0010368_abnormal_lymphatic_system0.86903702
130MP0005195_abnormal_posterior_eye0.86743630
131MP0005395_other_phenotype0.86338424
132MP0002933_joint_inflammation0.83905891
133MP0000858_altered_metastatic_potential0.83443231
134MP0004133_heterotaxia0.83095553
135MP0008877_abnormal_DNA_methylation0.82529703
136MP0000015_abnormal_ear_pigmentation0.80859754
137MP0005075_abnormal_melanosome_morpholog0.80100773
138MP0002075_abnormal_coat/hair_pigmentati0.79355980
139MP0000534_abnormal_ureter_morphology0.77533571
140MP0006276_abnormal_autonomic_nervous0.76967529
141MP0005408_hypopigmentation0.76790459
142MP0005275_abnormal_skin_tensile0.76008855
143MP0005394_taste/olfaction_phenotype0.74970213
144MP0005499_abnormal_olfactory_system0.74970213
145MP0005220_abnormal_exocrine_pancreas0.74832011
146MP0001970_abnormal_pain_threshold0.74456640
147MP0001529_abnormal_vocalization0.74267708
148MP0002210_abnormal_sex_determination0.74205702
149MP0003786_premature_aging0.73266026
150MP0005266_abnormal_metabolism0.73036314
151MP0002272_abnormal_nervous_system0.72252219
152MP0001340_abnormal_eyelid_morphology0.71309386
153MP0001293_anophthalmia0.71181281
154MP0005410_abnormal_fertilization0.70937501
155MP0003279_aneurysm0.70544466
156MP0004883_abnormal_blood_vessel0.69766508
157MP0002113_abnormal_skeleton_development0.69382847
158MP0000750_abnormal_muscle_regeneration0.68782583
159MP0001542_abnormal_bone_strength0.67938493
160MP0003077_abnormal_cell_cycle0.67110173
161MP0002752_abnormal_somatic_nervous0.66707524
162MP0003787_abnormal_imprinting0.66152535
163MP0001764_abnormal_homeostasis0.65583366
164MP0000026_abnormal_inner_ear0.65077151
165MP0002114_abnormal_axial_skeleton0.64962443
166MP0002095_abnormal_skin_pigmentation0.64941071
167MP0000470_abnormal_stomach_morphology0.63630902
168MP0002733_abnormal_thermal_nociception0.63519474
169MP0003186_abnormal_redox_activity0.62066624
170MP0000230_abnormal_systemic_arterial0.59105036
171MP0002064_seizures0.58452466
172MP0000371_diluted_coat_color0.57116341
173MP0002693_abnormal_pancreas_physiology0.56091279
174MP0000778_abnormal_nervous_system0.55877182

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)5.19763662
2Abnormal hemoglobin (HP:0011902)4.95826060
3Submucous cleft hard palate (HP:0000176)4.85328640
4Reticulocytopenia (HP:0001896)4.85120596
5Molar tooth sign on MRI (HP:0002419)4.42607252
6Abnormality of midbrain morphology (HP:0002418)4.42607252
7Lip pit (HP:0100267)4.07482961
8Nephronophthisis (HP:0000090)4.01901063
9Adrenal hypoplasia (HP:0000835)3.84654210
10Concave nail (HP:0001598)3.76921890
11Abnormality of the renal medulla (HP:0100957)3.69976593
12Pancreatic fibrosis (HP:0100732)3.62036268
13Bronchomalacia (HP:0002780)3.58533593
14Pulmonary artery stenosis (HP:0004415)3.51822987
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.41302543
16Tracheomalacia (HP:0002779)3.35777866
17Pendular nystagmus (HP:0012043)3.35537170
18Genetic anticipation (HP:0003743)3.27837629
193-Methylglutaconic aciduria (HP:0003535)3.13114136
20Congenital stationary night blindness (HP:0007642)3.11405960
21Diastasis recti (HP:0001540)3.08391000
22Macrocytic anemia (HP:0001972)3.01176284
23Abnormal mitochondria in muscle tissue (HP:0008316)2.98397834
24Down-sloping shoulders (HP:0200021)2.96862850
25Attenuation of retinal blood vessels (HP:0007843)2.89337860
26Chin dimple (HP:0010751)2.86543088
27Focal motor seizures (HP:0011153)2.86534121
28Acute encephalopathy (HP:0006846)2.81167717
29Parakeratosis (HP:0001036)2.78365101
30Abnormality of the renal cortex (HP:0011035)2.71849416
31Type II lissencephaly (HP:0007260)2.64910800
32Abnormality of the nasal septum (HP:0000419)2.64410252
33Secondary amenorrhea (HP:0000869)2.59012397
34Chronic hepatic failure (HP:0100626)2.58600570
35Progressive macrocephaly (HP:0004481)2.54098324
36Gaze-evoked nystagmus (HP:0000640)2.53920804
37Small hand (HP:0200055)2.52684478
38Polyuria (HP:0000103)2.50899422
39Progressive cerebellar ataxia (HP:0002073)2.50190458
40Clumsiness (HP:0002312)2.48629455
41Pallor (HP:0000980)2.46904704
42Dialeptic seizures (HP:0011146)2.46675501
43Periauricular skin pits (HP:0100277)2.46237794
44Preauricular pit (HP:0004467)2.46237794
45True hermaphroditism (HP:0010459)2.46068950
46Aplasia/hypoplasia of the uterus (HP:0008684)2.45286571
47Abnormality of alanine metabolism (HP:0010916)2.44089169
48Hyperalaninemia (HP:0003348)2.44089169
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.44089169
50Abnormal pupillary function (HP:0007686)2.41513029
51Natal tooth (HP:0000695)2.39469829
52Severe visual impairment (HP:0001141)2.39074854
53Tubular atrophy (HP:0000092)2.38954323
54Triphalangeal thumb (HP:0001199)2.35720392
55Bony spicule pigmentary retinopathy (HP:0007737)2.35309448
56Cerebellar dysplasia (HP:0007033)2.35005827
57Sclerocornea (HP:0000647)2.34922518
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.34366122
59Absent thumb (HP:0009777)2.32572674
60Abolished electroretinogram (ERG) (HP:0000550)2.32399336
61Congenital, generalized hypertrichosis (HP:0004540)2.30028244
62Inability to walk (HP:0002540)2.29614959
63Hyperventilation (HP:0002883)2.29217728
64Premature rupture of membranes (HP:0001788)2.27381072
65Colon cancer (HP:0003003)2.26424206
66Morphological abnormality of the middle ear (HP:0008609)2.24707881
67Breast hypoplasia (HP:0003187)2.24370040
68Hypothermia (HP:0002045)2.22825032
69Polydipsia (HP:0001959)2.21790177
70Abnormal drinking behavior (HP:0030082)2.21790177
71Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.21310912
72Ridged nail (HP:0001807)2.20925237
73Abnormal number of incisors (HP:0011064)2.20869305
74Rib fusion (HP:0000902)2.17913218
7511 pairs of ribs (HP:0000878)2.17578062
76Bifid uvula (HP:0000193)2.13496234
77Abnormal sex determination (HP:0012244)2.13218844
78Sex reversal (HP:0012245)2.13218844
79Congenital hepatic fibrosis (HP:0002612)2.12660102
80Hypoplasia of the pons (HP:0012110)2.11212896
81Hypoplastic ischia (HP:0003175)2.09873670
82Hepatocellular necrosis (HP:0001404)2.09667726
83Type I transferrin isoform profile (HP:0003642)2.09445545
84Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09419366
85Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09419366
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09308859
87Medial flaring of the eyebrow (HP:0010747)2.08727072
88Calf muscle hypertrophy (HP:0008981)2.08316571
89Median cleft lip (HP:0000161)2.07999045
90Abnormality of dental color (HP:0011073)2.05207245
91Hyperglycinuria (HP:0003108)2.04886949
92Aplasia/Hypoplasia of the patella (HP:0006498)2.04165110
93Retinitis pigmentosa (HP:0000510)2.04092224
94Abnormality of the nasolacrimal system (HP:0000614)2.04086474
95Increased density of long bones (HP:0006392)2.03590819
96Abnormality of proline metabolism (HP:0010907)2.03479987
97Hydroxyprolinuria (HP:0003080)2.03479987
98Depressed nasal ridge (HP:0000457)2.01697007
99Porencephaly (HP:0002132)2.00519809
100Pancreatic cysts (HP:0001737)1.99992509
101Popliteal pterygium (HP:0009756)1.99035288
102Syringomyelia (HP:0003396)1.96940983
103Spinal cord lesions (HP:0100561)1.96940983
104Muscle hypertrophy of the lower extremities (HP:0008968)1.96576338
105Mitochondrial inheritance (HP:0001427)1.96326304
106Abnormality of renal resorption (HP:0011038)1.95805021
107Chorioretinal atrophy (HP:0000533)1.94846382
108Poikiloderma (HP:0001029)1.93974124
109Abnormal respiratory motile cilium physiology (HP:0012261)1.93664085
110Anencephaly (HP:0002323)1.93362358
111Abnormal pancreas size (HP:0012094)1.92680433
112Hepatoblastoma (HP:0002884)1.92566528
113Nasolacrimal duct obstruction (HP:0000579)1.91332691
114Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90818071
115Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90581361
116Abnormal protein N-linked glycosylation (HP:0012347)1.90581361
117Abnormal protein glycosylation (HP:0012346)1.90581361
118Abnormal glycosylation (HP:0012345)1.90581361
119Increased corneal curvature (HP:0100692)1.90213695
120Keratoconus (HP:0000563)1.90213695
121Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88009839
122Abnormality of the lacrimal duct (HP:0011481)1.86975386
123Patent foramen ovale (HP:0001655)1.86813766
124Obstructive sleep apnea (HP:0002870)1.86418006
125Progressive external ophthalmoplegia (HP:0000590)1.86345021
126Abnormality of the pons (HP:0007361)1.86001995
127Decreased circulating renin level (HP:0003351)1.85544712
128Absent eyebrow (HP:0002223)1.84873667
129Opisthotonus (HP:0002179)1.84869637
130Abnormal rod and cone electroretinograms (HP:0008323)1.84041906
131Decreased central vision (HP:0007663)1.83747282
132Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83586277
133Abnormal ciliary motility (HP:0012262)1.83493925
134Tubulointerstitial nephritis (HP:0001970)1.83076233
135Fragile nails (HP:0001808)1.83065069
136Bile duct proliferation (HP:0001408)1.82355220
137Abnormal biliary tract physiology (HP:0012439)1.82355220
138Congenital sensorineural hearing impairment (HP:0008527)1.82050140
139Abnormal urine output (HP:0012590)1.81716411
140Abnormality of the incisor (HP:0000676)1.80838486
141Abnormal number of erythroid precursors (HP:0012131)1.80722753
142Ileus (HP:0002595)1.80412726
143Renal dysplasia (HP:0000110)1.79172600
144Abnormality of cells of the erythroid lineage (HP:0012130)1.78915212
145Abnormality of macular pigmentation (HP:0008002)1.78815792
146Absent eyelashes (HP:0000561)1.78640141
147Thyroid-stimulating hormone excess (HP:0002925)1.78013309
148Fibular aplasia (HP:0002990)1.77428666
149Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.76945941
150Optic disc pallor (HP:0000543)1.76529110
151Hepatic necrosis (HP:0002605)1.76171949
152Abnormality of the pulmonary veins (HP:0011718)1.75774347
153Coarctation of aorta (HP:0001680)1.75644115
154Bifid tongue (HP:0010297)1.75604657
155Aplasia/Hypoplasia of the tongue (HP:0010295)1.74775185
156Aplasia/Hypoplasia of the tibia (HP:0005772)1.74619829
157Abnormality of the metopic suture (HP:0005556)1.73622685
158Calcaneovalgus deformity (HP:0001848)1.72234199
159Horseshoe kidney (HP:0000085)1.71346896
160Male pseudohermaphroditism (HP:0000037)1.70802346
161Patellar aplasia (HP:0006443)1.70743382
162Seborrheic dermatitis (HP:0001051)1.70535694
163Increased hepatocellular lipid droplets (HP:0006565)1.70383155
164Abnormality of incisor morphology (HP:0011063)1.67976174
165Short middle phalanx of the 5th finger (HP:0004220)1.66775265
166Dry hair (HP:0011359)1.66591125
167Corneal dystrophy (HP:0001131)1.66463095
168Rectal prolapse (HP:0002035)1.65409015
169Abnormality of the parietal bone (HP:0002696)1.65301386
170Flared metaphyses (HP:0003015)1.65017386
171Increased number of teeth (HP:0011069)1.64301971
172Anomalous pulmonary venous return (HP:0010772)1.64133580
173Acute necrotizing encephalopathy (HP:0006965)1.61457700
174Increased CSF lactate (HP:0002490)1.60746926
175Short nail (HP:0001799)1.60564080
176Abnormality of the distal phalanges of the toes (HP:0010182)1.59814843
177Skin pits (HP:0100276)1.59566764
178Partial duplication of the phalanx of hand (HP:0009999)1.57356112
179Abnormal lung lobation (HP:0002101)1.55887417
180Lipid accumulation in hepatocytes (HP:0006561)1.55734256
181Aplasia of the musculature (HP:0100854)1.54923704
182Cystic liver disease (HP:0006706)1.54753802
183Broad toe (HP:0001837)1.53792084

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK17.48900918
2TLK16.04296529
3LATS14.91205357
4LATS23.45070414
5CASK3.00304302
6CDK192.96435414
7NTRK22.91575339
8MKNK22.57407800
9EIF2AK12.53221682
10ADRBK22.45599362
11RPS6KA42.32326909
12STK38L2.26186564
13EPHB22.21980738
14INSRR2.13532174
15EPHA22.11301340
16MKNK12.04412143
17NEK22.03467016
18ACVR1B2.03288785
19SRPK12.03263686
20MST42.02995924
21NME21.97493079
22PLK41.82751089
23NEK91.73104830
24STK381.68361663
25STK161.56770691
26GRK11.47910741
27PBK1.46541032
28CDC71.43472668
29ZAK1.42391265
30ERBB31.42116992
31PINK11.41278657
32BUB11.40488467
33WNK41.34747183
34VRK21.32927869
35BCR1.30793363
36MAP2K71.29475249
37PRKD21.29258334
38BMPR1B1.27976353
39YES11.25341853
40EIF2AK31.20644739
41MAP4K11.16762631
42MAP3K41.16430796
43IRAK11.15002463
44TAOK31.08319021
45AKT31.06431091
46IRAK31.03254828
47WNK30.93136543
48TGFBR10.92933195
49TXK0.92218582
50TESK20.88492163
51MAPKAPK30.88487113
52OXSR10.88284012
53PIM20.87911105
54DAPK30.87511813
55IRAK40.87189235
56NUAK10.85948515
57TESK10.84858830
58MAPK150.81189505
59MYLK0.81073971
60CHUK0.79361913
61MAP2K20.79347512
62MAP4K20.78296776
63LIMK10.77578128
64MAP3K100.77150664
65MAP3K110.74872141
66CLK10.74328943
67PIK3CG0.73521455
68EIF2AK20.73036824
69PIK3CA0.72789743
70RPS6KA50.70922223
71PRKCI0.68721898
72BRSK10.68609214
73BMPR20.67579294
74TNK20.67323310
75MAPK130.66171757
76CAMK10.64788893
77DAPK20.63659585
78SIK20.58935287
79NME10.58005233
80IRAK20.57713535
81PRKAA20.57292558
82AURKB0.57071199
83CHEK20.56766594
84DYRK1B0.55518588
85ADRBK10.55175969
86STK30.54677495
87RPS6KB20.54414540
88CSNK1A1L0.54190362
89ERBB20.53765772
90BLK0.52155376
91TEC0.51102529
92MELK0.48862725
93TRPM70.48199247
94EPHA30.48017399
95PRKCG0.47622416
96LRRK20.46297793
97PRKCE0.46157421
98DYRK1A0.45605202
99CDK70.45072421
100STK390.44048730
101RPS6KA60.43014324
102NLK0.42678174
103VRK10.42494180
104IKBKE0.41220228
105PRKD10.41161887
106MAP3K70.40459911
107BRAF0.39927900
108FES0.39802986
109CSNK2A10.39424124
110STK40.39276410
111AURKA0.38857309
112PNCK0.38480515
113STK240.37809238
114PRKD30.37620888
115PRKACB0.37595093
116MAP2K60.36665640
117ABL20.36554522
118PRKACA0.36538286
119ATR0.35477058
120DYRK30.35212780
121CSNK1A10.35108524
122GRK70.35069217
123FER0.35026007
124STK110.34748290
125CDK80.34558543
126PAK20.33797467
127PRKCQ0.31704844
128PLK20.31022465
129KIT0.30521095
130PLK30.29960659
131PIM10.29353316
132TYK20.29341087
133STK100.28155620
134CHEK10.28130440
135DYRK20.28111158
136MAPKAPK20.28038351
137PKN10.27437829
138CDC42BPA0.26571710
139FRK0.26129140
140GSK3B0.26016587
141AKT10.25910180
142CSNK1E0.25500977
143MATK0.25415241
144CDK30.23748916
145WEE10.23495374
146ILK0.23379978
147PLK10.21091497
148ROCK10.20899238
149OBSCN0.19933575
150ROCK20.19588323
151RPS6KC10.19421208
152RPS6KL10.19421208
153UHMK10.19107517
154PTK2B0.17854073
155IKBKB0.17043612
156CAMK2G0.16874652
157MARK30.14817271

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.07906420
2Protein export_Homo sapiens_hsa030603.67145882
3RNA polymerase_Homo sapiens_hsa030203.42193071
4Homologous recombination_Homo sapiens_hsa034403.29795564
5Spliceosome_Homo sapiens_hsa030402.80939382
6Mismatch repair_Homo sapiens_hsa034302.72319103
7Proteasome_Homo sapiens_hsa030502.51042735
8DNA replication_Homo sapiens_hsa030302.47513413
9Olfactory transduction_Homo sapiens_hsa047401.97563577
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82905005
11Pyrimidine metabolism_Homo sapiens_hsa002401.78835790
12Oxidative phosphorylation_Homo sapiens_hsa001901.77611405
13Steroid hormone biosynthesis_Homo sapiens_hsa001401.75057798
14Nucleotide excision repair_Homo sapiens_hsa034201.67241471
15Fanconi anemia pathway_Homo sapiens_hsa034601.66972359
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63350960
17Base excision repair_Homo sapiens_hsa034101.63316996
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63269185
19Cell cycle_Homo sapiens_hsa041101.62708985
20Ovarian steroidogenesis_Homo sapiens_hsa049131.62507106
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61015478
22Basal transcription factors_Homo sapiens_hsa030221.58878564
23Nicotine addiction_Homo sapiens_hsa050331.58515673
24p53 signaling pathway_Homo sapiens_hsa041151.57213737
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54100067
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.53639503
27Parkinsons disease_Homo sapiens_hsa050121.53596054
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53169073
29Taste transduction_Homo sapiens_hsa047421.53034548
30Sulfur relay system_Homo sapiens_hsa041221.50868086
31Morphine addiction_Homo sapiens_hsa050321.45960558
32Chemical carcinogenesis_Homo sapiens_hsa052041.34798223
33Huntingtons disease_Homo sapiens_hsa050161.32599949
34RNA transport_Homo sapiens_hsa030131.29686858
35Bladder cancer_Homo sapiens_hsa052191.29388767
36ABC transporters_Homo sapiens_hsa020101.25914330
37Basal cell carcinoma_Homo sapiens_hsa052171.23921244
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.20831158
39Ether lipid metabolism_Homo sapiens_hsa005651.18058836
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17246081
41Dorso-ventral axis formation_Homo sapiens_hsa043201.16336546
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13507511
43Thyroid cancer_Homo sapiens_hsa052161.13038584
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11956660
45Sphingolipid metabolism_Homo sapiens_hsa006001.11760720
46Collecting duct acid secretion_Homo sapiens_hsa049661.11089358
47Alzheimers disease_Homo sapiens_hsa050101.09262306
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05258017
49Hedgehog signaling pathway_Homo sapiens_hsa043401.04322355
50RNA degradation_Homo sapiens_hsa030181.03733305
51Tryptophan metabolism_Homo sapiens_hsa003801.03100115
52Melanoma_Homo sapiens_hsa052181.01463268
53TGF-beta signaling pathway_Homo sapiens_hsa043501.01273291
54Hippo signaling pathway_Homo sapiens_hsa043900.96471160
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94974523
56Arachidonic acid metabolism_Homo sapiens_hsa005900.94159915
57MicroRNAs in cancer_Homo sapiens_hsa052060.91955204
58Steroid biosynthesis_Homo sapiens_hsa001000.91546775
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.90312601
60Prostate cancer_Homo sapiens_hsa052150.88337472
61Purine metabolism_Homo sapiens_hsa002300.87429062
62mRNA surveillance pathway_Homo sapiens_hsa030150.86383968
63Salivary secretion_Homo sapiens_hsa049700.84598937
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84230592
65Nitrogen metabolism_Homo sapiens_hsa009100.83867466
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82621426
67Calcium signaling pathway_Homo sapiens_hsa040200.80877262
68Herpes simplex infection_Homo sapiens_hsa051680.80596726
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80490910
70Butanoate metabolism_Homo sapiens_hsa006500.80288351
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79699974
72Systemic lupus erythematosus_Homo sapiens_hsa053220.78684228
73Notch signaling pathway_Homo sapiens_hsa043300.78414057
74Wnt signaling pathway_Homo sapiens_hsa043100.78411078
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78172666
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76552173
77Glycerolipid metabolism_Homo sapiens_hsa005610.74986527
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74359875
79Glutamatergic synapse_Homo sapiens_hsa047240.73379391
80Selenocompound metabolism_Homo sapiens_hsa004500.72476401
81Epstein-Barr virus infection_Homo sapiens_hsa051690.72411623
82Folate biosynthesis_Homo sapiens_hsa007900.71851946
83Other glycan degradation_Homo sapiens_hsa005110.71295362
84Retinol metabolism_Homo sapiens_hsa008300.69945299
85Tight junction_Homo sapiens_hsa045300.68796970
86GABAergic synapse_Homo sapiens_hsa047270.67751314
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67710184
88Vitamin digestion and absorption_Homo sapiens_hsa049770.64230653
89ECM-receptor interaction_Homo sapiens_hsa045120.64060336
90N-Glycan biosynthesis_Homo sapiens_hsa005100.61786127
91Proteoglycans in cancer_Homo sapiens_hsa052050.61011042
92Non-homologous end-joining_Homo sapiens_hsa034500.60832965
93Serotonergic synapse_Homo sapiens_hsa047260.60301618
94Phototransduction_Homo sapiens_hsa047440.60030323
95Metabolic pathways_Homo sapiens_hsa011000.58903113
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57633234
97Melanogenesis_Homo sapiens_hsa049160.56377943
98Circadian entrainment_Homo sapiens_hsa047130.54502381
99HTLV-I infection_Homo sapiens_hsa051660.53890404
100Measles_Homo sapiens_hsa051620.52942723
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52068124
102Insulin secretion_Homo sapiens_hsa049110.51956389
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.51429810
104Pathways in cancer_Homo sapiens_hsa052000.51118490
105Small cell lung cancer_Homo sapiens_hsa052220.50831996
106Cardiac muscle contraction_Homo sapiens_hsa042600.50142308
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49988091
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47517936
109Adherens junction_Homo sapiens_hsa045200.47459471
110Axon guidance_Homo sapiens_hsa043600.47324199
111Glutathione metabolism_Homo sapiens_hsa004800.47024222
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46933815
113Renin-angiotensin system_Homo sapiens_hsa046140.46511384
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44343894
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44228682
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43992405
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43456903
118Hepatitis C_Homo sapiens_hsa051600.42976719
119Lysine degradation_Homo sapiens_hsa003100.41956527
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40150251
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38880244
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36890907
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.36263584
124Glioma_Homo sapiens_hsa052140.35763287
125beta-Alanine metabolism_Homo sapiens_hsa004100.34537235
126Alcoholism_Homo sapiens_hsa050340.34058107
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.33773927
128Histidine metabolism_Homo sapiens_hsa003400.32977163
129Hepatitis B_Homo sapiens_hsa051610.32261956
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31517658
131Pertussis_Homo sapiens_hsa051330.31266500
132Dilated cardiomyopathy_Homo sapiens_hsa054140.30444966
133Thyroid hormone synthesis_Homo sapiens_hsa049180.30409534
134One carbon pool by folate_Homo sapiens_hsa006700.29482420
135Shigellosis_Homo sapiens_hsa051310.29377443
136Sulfur metabolism_Homo sapiens_hsa009200.28811077
137Cocaine addiction_Homo sapiens_hsa050300.28707751
138Bile secretion_Homo sapiens_hsa049760.28641862
139Intestinal immune network for IgA production_Homo sapiens_hsa046720.28639202
140Chronic myeloid leukemia_Homo sapiens_hsa052200.28059723
141Arginine and proline metabolism_Homo sapiens_hsa003300.27872829
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.26749215
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.25886352
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25831920
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25804452
146Fatty acid elongation_Homo sapiens_hsa000620.25779512
147Regulation of autophagy_Homo sapiens_hsa041400.25430148
148Focal adhesion_Homo sapiens_hsa045100.25284183
149Linoleic acid metabolism_Homo sapiens_hsa005910.24976416
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24852773
151Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24648392
152FoxO signaling pathway_Homo sapiens_hsa040680.23594659
153Hematopoietic cell lineage_Homo sapiens_hsa046400.23066949
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20831985

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