ORC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.78231277
2kinetochore organization (GO:0051383)4.32405590
3CENP-A containing nucleosome assembly (GO:0034080)4.29418831
4telomere maintenance via semi-conservative replication (GO:0032201)4.29183979
5DNA strand elongation involved in DNA replication (GO:0006271)4.28849354
6nuclear pore organization (GO:0006999)4.27005701
7mitotic metaphase plate congression (GO:0007080)4.23537834
8DNA strand elongation (GO:0022616)4.22989647
9DNA replication initiation (GO:0006270)4.21152159
10chromatin remodeling at centromere (GO:0031055)4.18178469
11nuclear pore complex assembly (GO:0051292)4.14321341
12telomere maintenance via recombination (GO:0000722)4.11745127
13IMP biosynthetic process (GO:0006188)4.11495437
14mitotic sister chromatid cohesion (GO:0007064)4.02045461
15nucleobase biosynthetic process (GO:0046112)4.01472165
16purine nucleobase biosynthetic process (GO:0009113)4.00986179
17meiotic chromosome segregation (GO:0045132)3.98414133
18mitotic recombination (GO:0006312)3.96943512
19DNA unwinding involved in DNA replication (GO:0006268)3.88425668
20DNA replication-independent nucleosome organization (GO:0034724)3.88214540
21DNA replication-independent nucleosome assembly (GO:0006336)3.88214540
22establishment of integrated proviral latency (GO:0075713)3.87307164
23protein localization to kinetochore (GO:0034501)3.84882749
24metaphase plate congression (GO:0051310)3.84626347
25DNA ligation (GO:0006266)3.82032415
26attachment of spindle microtubules to kinetochore (GO:0008608)3.81619922
27kinetochore assembly (GO:0051382)3.80088084
28negative regulation of DNA recombination (GO:0045910)3.76370843
29proteasome assembly (GO:0043248)3.75099308
30cullin deneddylation (GO:0010388)3.73152702
31regulation of mitotic spindle checkpoint (GO:1903504)3.70997669
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.70997669
33mitotic nuclear envelope disassembly (GO:0007077)3.70211950
34DNA replication checkpoint (GO:0000076)3.66380591
35telomere maintenance via telomere lengthening (GO:0010833)3.61970839
36non-recombinational repair (GO:0000726)3.61797715
37double-strand break repair via nonhomologous end joining (GO:0006303)3.61797715
38establishment of chromosome localization (GO:0051303)3.53856442
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.53455176
40histone exchange (GO:0043486)3.52650130
41protein localization to chromosome, centromeric region (GO:0071459)3.49743281
42regulation of helicase activity (GO:0051095)3.46660050
43mitotic chromosome condensation (GO:0007076)3.46603416
44IMP metabolic process (GO:0046040)3.45941624
45telomere organization (GO:0032200)3.42986098
46ribosomal small subunit assembly (GO:0000028)3.42888163
47telomere maintenance (GO:0000723)3.42366295
48snRNA processing (GO:0016180)3.40987276
49nuclear envelope disassembly (GO:0051081)3.40830458
50membrane disassembly (GO:0030397)3.40830458
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.40215869
52protein deneddylation (GO:0000338)3.40087376
53spindle assembly checkpoint (GO:0071173)3.39412121
54DNA catabolic process, exonucleolytic (GO:0000738)3.38127390
55spindle checkpoint (GO:0031577)3.38102064
56maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.38099650
57pore complex assembly (GO:0046931)3.35571454
58negative regulation of mitotic sister chromatid separation (GO:2000816)3.35221551
59negative regulation of mitotic sister chromatid segregation (GO:0033048)3.35221551
60negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.35221551
61negative regulation of sister chromatid segregation (GO:0033046)3.35221551
62negative regulation of DNA-dependent DNA replication (GO:2000104)3.35201067
63regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.34688125
64regulation of spindle organization (GO:0090224)3.33997768
65ribosome biogenesis (GO:0042254)3.33091613
66regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.32234040
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31520205
68mitotic spindle assembly checkpoint (GO:0007094)3.31491813
69regulation of mitotic metaphase/anaphase transition (GO:0030071)3.28371667
70negative regulation of chromosome segregation (GO:0051985)3.28272762
71mitotic sister chromatid segregation (GO:0000070)3.24696432
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23029323
73negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.22610084
74sister chromatid segregation (GO:0000819)3.21883053
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21622584
76resolution of meiotic recombination intermediates (GO:0000712)3.21313779
77synapsis (GO:0007129)3.20465500
78protein K6-linked ubiquitination (GO:0085020)3.19751599
79regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18782121
80mitotic spindle checkpoint (GO:0071174)3.18250240
81regulation of nuclear cell cycle DNA replication (GO:0033262)3.17029102
82regulation of DNA endoreduplication (GO:0032875)3.16580271
83regulation of double-strand break repair via homologous recombination (GO:0010569)3.16175618
84regulation of mitotic sister chromatid separation (GO:0010965)3.15248253
85regulation of mitotic sister chromatid segregation (GO:0033047)3.15248253
86regulation of sister chromatid segregation (GO:0033045)3.15248253
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14814547
88somatic diversification of immune receptors via somatic mutation (GO:0002566)3.13665264
89somatic hypermutation of immunoglobulin genes (GO:0016446)3.13665264
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.13113245
91snRNA metabolic process (GO:0016073)3.13057452
92histone H2A acetylation (GO:0043968)3.10040833
93replication fork processing (GO:0031297)3.09463085
94L-serine metabolic process (GO:0006563)3.09088588
95DNA replication-dependent nucleosome assembly (GO:0006335)3.08602834
96DNA replication-dependent nucleosome organization (GO:0034723)3.08602834
97positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08513098
98regulation of centriole replication (GO:0046599)3.07791698
99mismatch repair (GO:0006298)3.07453662
100DNA geometric change (GO:0032392)3.06966463
101regulation of centrosome cycle (GO:0046605)3.06509716
102DNA duplex unwinding (GO:0032508)3.05198975
103water-soluble vitamin biosynthetic process (GO:0042364)3.04976632
104intra-S DNA damage checkpoint (GO:0031573)3.04861369
105telomere maintenance via telomerase (GO:0007004)3.01992237
106regulation of chromosome segregation (GO:0051983)2.98774634
107folic acid-containing compound biosynthetic process (GO:0009396)2.98767227
108DNA strand renaturation (GO:0000733)2.98579300
109recombinational repair (GO:0000725)2.98378571
110DNA damage response, detection of DNA damage (GO:0042769)2.98022183
111negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97680356
112negative regulation of ligase activity (GO:0051352)2.97680356
113somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.97013262
114somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.97013262
115isotype switching (GO:0045190)2.97013262
116maturation of 5.8S rRNA (GO:0000460)2.96585935
117chromosome segregation (GO:0007059)2.96583833
118viral mRNA export from host cell nucleus (GO:0046784)2.96304333
119regulation of histone H3-K9 methylation (GO:0051570)2.95992514
120regulation of DNA damage checkpoint (GO:2000001)2.95704480
121double-strand break repair via homologous recombination (GO:0000724)2.95375321
122response to X-ray (GO:0010165)2.94521285
123DNA synthesis involved in DNA repair (GO:0000731)2.93596007
124mitotic G2/M transition checkpoint (GO:0044818)2.92936093
125formation of translation preinitiation complex (GO:0001731)2.92732748
126ATP-dependent chromatin remodeling (GO:0043044)2.92627374
127histone mRNA metabolic process (GO:0008334)2.90118225
128establishment of viral latency (GO:0019043)2.89865364
129establishment of protein localization to mitochondrial membrane (GO:0090151)2.88984750
130postreplication repair (GO:0006301)2.88291101
131ribosome assembly (GO:0042255)2.88002358
132translesion synthesis (GO:0019985)2.87288688
133deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86149034
134amino acid activation (GO:0043038)2.85032036
135tRNA aminoacylation (GO:0043039)2.85032036
136pseudouridine synthesis (GO:0001522)2.84738098
137tRNA aminoacylation for protein translation (GO:0006418)2.82262374
138dosage compensation (GO:0007549)2.82165113
139peptidyl-histidine modification (GO:0018202)2.79874886
140RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.79820751
141chromatin assembly or disassembly (GO:0006333)2.77000979

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.94012609
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.20720666
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.08440673
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.84196969
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25127803
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17395213
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.80281761
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63385307
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.63382149
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61534353
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60368293
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.60239818
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.58597006
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.44059086
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41365443
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39702934
17VDR_23849224_ChIP-Seq_CD4+_Human2.36356075
18ZNF274_21170338_ChIP-Seq_K562_Hela2.30244447
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.29610195
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29517446
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.28858869
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27768755
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24591987
24YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22020293
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20241644
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.19890722
27FOXP3_21729870_ChIP-Seq_TREG_Human2.17285336
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17231245
29RBPJ_22232070_ChIP-Seq_NCS_Mouse2.16982190
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16554015
31ELK1_19687146_ChIP-ChIP_HELA_Human2.05640057
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02862825
33* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02833089
34VDR_22108803_ChIP-Seq_LS180_Human1.94506694
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.92047640
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91570225
37* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91014918
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90964229
39AR_21909140_ChIP-Seq_LNCAP_Human1.87391691
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87145516
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86323951
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.85496336
43XRN2_22483619_ChIP-Seq_HELA_Human1.85220522
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81404084
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76947622
46TAF15_26573619_Chip-Seq_HEK293_Human1.76278014
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.74345807
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73871736
49CIITA_25753668_ChIP-Seq_RAJI_Human1.71448392
50DCP1A_22483619_ChIP-Seq_HELA_Human1.70237260
51GABP_19822575_ChIP-Seq_HepG2_Human1.69277811
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63200127
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62046345
54IGF1R_20145208_ChIP-Seq_DFB_Human1.61987093
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59820928
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55231508
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52942863
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51900848
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.51083094
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51068212
61TTF2_22483619_ChIP-Seq_HELA_Human1.50769427
62P300_19829295_ChIP-Seq_ESCs_Human1.48621402
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48416952
64GBX2_23144817_ChIP-Seq_PC3_Human1.47237343
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46364532
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45259135
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.41359613
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41145052
69KDM5A_27292631_Chip-Seq_BREAST_Human1.38818848
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37766376
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35343450
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32658718
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32177972
74GATA1_22025678_ChIP-Seq_K562_Human1.29907311
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27784399
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.24503521
77IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22114212
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19441077
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.18620883
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17183977
81* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16276690
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15297491
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14079195
84TFEB_21752829_ChIP-Seq_HELA_Human1.11651580
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11305754
86MYC_22102868_ChIP-Seq_BL_Human1.10558683
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08607957
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08406384
89SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08389447
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07932908
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05889330
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05058199
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04956444
94CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02275613
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.00915331
96SPI1_23547873_ChIP-Seq_NB4_Human1.00717449
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00036229
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99957271
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98576464
100PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97898739
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95374432
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95258991
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94153349
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94029403
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93075573
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92390542
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92223158
108SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92157893
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92139829
110CBP_20019798_ChIP-Seq_JUKART_Human0.92139829
111KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91250523
112EWS_26573619_Chip-Seq_HEK293_Human0.90215779
113NFE2_27457419_Chip-Seq_LIVER_Mouse0.89223818
114IRF1_19129219_ChIP-ChIP_H3396_Human0.88930383
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88794069
116CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87308557
117HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87107902
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84311956
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84263684
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84143149
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82745924
122SOX2_19829295_ChIP-Seq_ESCs_Human0.82513594
123NANOG_19829295_ChIP-Seq_ESCs_Human0.82513594
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82429050
125MYC_18940864_ChIP-ChIP_HL60_Human0.82138691
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81397151
127KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77145231
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75766017
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.74612472
130BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.73463827
131FUS_26573619_Chip-Seq_HEK293_Human0.73144543
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.70461393
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.69788640
134FLI1_27457419_Chip-Seq_LIVER_Mouse0.69608613
135NANOG_21062744_ChIP-ChIP_HESCs_Human0.69573249
136FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.67563561
137MYB_21317192_ChIP-Seq_ERMYB_Mouse0.66013558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.78787688
2MP0010094_abnormal_chromosome_stability4.69160354
3MP0008057_abnormal_DNA_replication4.20128590
4MP0003111_abnormal_nucleus_morphology4.17054091
5MP0008058_abnormal_DNA_repair3.90845905
6MP0003077_abnormal_cell_cycle3.71004978
7MP0002396_abnormal_hematopoietic_system3.53408707
8MP0004957_abnormal_blastocyst_morpholog3.42001264
9MP0008007_abnormal_cellular_replicative3.21547303
10MP0008877_abnormal_DNA_methylation2.83806894
11MP0002102_abnormal_ear_morphology2.66911605
12MP0010352_gastrointestinal_tract_polyps2.17833163
13MP0001529_abnormal_vocalization2.02133322
14MP0003123_paternal_imprinting2.01981192
15MP0004808_abnormal_hematopoietic_stem2.00471145
16MP0008932_abnormal_embryonic_tissue1.94833225
17MP0010307_abnormal_tumor_latency1.94051723
18MP0009697_abnormal_copulation1.93137957
19MP0003121_genomic_imprinting1.89323489
20MP0000350_abnormal_cell_proliferation1.82824063
21MP0003880_abnormal_central_pattern1.76298182
22MP0003787_abnormal_imprinting1.75090950
23MP0003763_abnormal_thymus_physiology1.71792741
24MP0003786_premature_aging1.71703809
25MP0006072_abnormal_retinal_apoptosis1.70440478
26MP0000490_abnormal_crypts_of1.65837555
27MP0000569_abnormal_digit_pigmentation1.65235417
28MP0001730_embryonic_growth_arrest1.64464533
29MP0001984_abnormal_olfaction1.56943823
30MP0006035_abnormal_mitochondrial_morpho1.55601491
31MP0003567_abnormal_fetal_cardiomyocyte1.51052007
32MP0008789_abnormal_olfactory_epithelium1.47950513
33MP0005380_embryogenesis_phenotype1.39261687
34MP0001672_abnormal_embryogenesis/_devel1.39261687
35MP0006292_abnormal_olfactory_placode1.38995360
36MP0004133_heterotaxia1.37762650
37MP0001188_hyperpigmentation1.35825308
38MP0003136_yellow_coat_color1.35801235
39MP0001697_abnormal_embryo_size1.33695903
40MP0001293_anophthalmia1.28914408
41MP0004147_increased_porphyrin_level1.28729212
42MP0003984_embryonic_growth_retardation1.28527823
43MP0004197_abnormal_fetal_growth/weight/1.28334729
44MP0002233_abnormal_nose_morphology1.28157517
45MP0002088_abnormal_embryonic_growth/wei1.26264942
46MP0000703_abnormal_thymus_morphology1.25034242
47MP0003122_maternal_imprinting1.24843824
48MP0004215_abnormal_myocardial_fiber1.24268508
49MP0000313_abnormal_cell_death1.23807991
50MP0002095_abnormal_skin_pigmentation1.23794323
51MP0002398_abnormal_bone_marrow1.22517979
52MP0000372_irregular_coat_pigmentation1.19382613
53MP0002080_prenatal_lethality1.17387317
54MP0002019_abnormal_tumor_incidence1.16561091
55MP0005499_abnormal_olfactory_system1.16342824
56MP0005394_taste/olfaction_phenotype1.16342824
57MP0003119_abnormal_digestive_system1.16138214
58MP0006036_abnormal_mitochondrial_physio1.15735906
59MP0000647_abnormal_sebaceous_gland1.15074221
60MP0010030_abnormal_orbit_morphology1.14602081
61MP0002210_abnormal_sex_determination1.14410552
62MP0003806_abnormal_nucleotide_metabolis1.12659765
63MP0005397_hematopoietic_system_phenotyp1.12204158
64MP0001545_abnormal_hematopoietic_system1.12204158
65MP0001485_abnormal_pinna_reflex1.11569893
66MP0002009_preneoplasia1.10903760
67MP0005253_abnormal_eye_physiology1.10770897
68MP0002938_white_spotting1.10757980
69MP0003941_abnormal_skin_development1.09946651
70MP0001119_abnormal_female_reproductive1.09901765
71MP0002085_abnormal_embryonic_tissue1.09049649
72MP0003890_abnormal_embryonic-extraembry1.09003528
73MP0002086_abnormal_extraembryonic_tissu1.08805139
74MP0000015_abnormal_ear_pigmentation1.08775339
75MP0000689_abnormal_spleen_morphology1.07967878
76MP0002084_abnormal_developmental_patter1.07259441
77MP0002722_abnormal_immune_system1.06968268
78MP0002837_dystrophic_cardiac_calcinosis1.05838186
79MP0003943_abnormal_hepatobiliary_system1.03542064
80MP0002736_abnormal_nociception_after1.03051735
81MP0002090_abnormal_vision1.02384793
82MP0001835_abnormal_antigen_presentation1.01572950
83MP0003221_abnormal_cardiomyocyte_apopto1.00147423
84MP0005075_abnormal_melanosome_morpholog0.98513530
85MP0006276_abnormal_autonomic_nervous0.97399742
86MP0003186_abnormal_redox_activity0.96957718
87MP0005248_abnormal_Harderian_gland0.95477100
88MP0005174_abnormal_tail_pigmentation0.95052564
89MP0005367_renal/urinary_system_phenotyp0.94586465
90MP0000516_abnormal_urinary_system0.94586465
91MP0002006_tumorigenesis0.92197791
92MP0005076_abnormal_cell_differentiation0.91627259
93MP0003195_calcinosis0.91370462
94MP0008995_early_reproductive_senescence0.90953509
95MP0005084_abnormal_gallbladder_morpholo0.90891227
96MP0001177_atelectasis0.90186171
97MP0002075_abnormal_coat/hair_pigmentati0.89990167
98MP0001145_abnormal_male_reproductive0.89498199
99MP0005671_abnormal_response_to0.89428551
100MP0000566_synostosis0.87961266
101MP0001186_pigmentation_phenotype0.87494770
102MP0001929_abnormal_gametogenesis0.87234524
103MP0003755_abnormal_palate_morphology0.86825384
104MP0002254_reproductive_system_inflammat0.86498417
105MP0000049_abnormal_middle_ear0.86026108
106MP0005551_abnormal_eye_electrophysiolog0.85683009
107MP0009703_decreased_birth_body0.85342840
108MP0002429_abnormal_blood_cell0.85333509
109MP0000653_abnormal_sex_gland0.84365076
110MP0001299_abnormal_eye_distance/0.81895833
111MP0002697_abnormal_eye_size0.81778972
112MP0002166_altered_tumor_susceptibility0.81451798
113MP0000631_abnormal_neuroendocrine_gland0.81153817
114MP0003137_abnormal_impulse_conducting0.80514997
115MP0003718_maternal_effect0.79805740
116MP0002111_abnormal_tail_morphology0.79749722
117MP0001800_abnormal_humoral_immune0.79723184
118MP0002234_abnormal_pharynx_morphology0.79595074
119MP0009672_abnormal_birth_weight0.79559071
120MP0003698_abnormal_male_reproductive0.79378463
121MP0000427_abnormal_hair_cycle0.78887951
122MP0000716_abnormal_immune_system0.78775145
123MP0005391_vision/eye_phenotype0.77870804
124MP0006054_spinal_hemorrhage0.77759612
125MP0009333_abnormal_splenocyte_physiolog0.77235127
126MP0005389_reproductive_system_phenotype0.75977395
127MP0001286_abnormal_eye_development0.75654761
128MP0003385_abnormal_body_wall0.75591770
129MP0000371_diluted_coat_color0.74116985
130MP0003861_abnormal_nervous_system0.72787753
131MP0001324_abnormal_eye_pigmentation0.72554313
132MP0005171_absent_coat_pigmentation0.72461528
133MP0001919_abnormal_reproductive_system0.72342170
134MP0005384_cellular_phenotype0.72335773
135MP0002160_abnormal_reproductive_system0.72332197
136MP0000358_abnormal_cell_content/0.68636406
137MP0003937_abnormal_limbs/digits/tail_de0.67752448
138MP0002420_abnormal_adaptive_immunity0.66396989
139MP0003315_abnormal_perineum_morphology0.66101757
140MP0001986_abnormal_taste_sensitivity0.65889474
141MP0002877_abnormal_melanocyte_morpholog0.65715941
142MP0001819_abnormal_immune_cell0.63982239
143MP0002132_abnormal_respiratory_system0.62055471
144MP0002452_abnormal_antigen_presenting0.61499999
145MP0005621_abnormal_cell_physiology0.57146875
146MP0005409_darkened_coat_color0.57040220
147MP0000428_abnormal_craniofacial_morphol0.56311090
148MP0002751_abnormal_autonomic_nervous0.55961197
149MP0002163_abnormal_gland_morphology0.55077889
150MP0002277_abnormal_respiratory_mucosa0.54500492
151MP0002109_abnormal_limb_morphology0.53113526

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.49670496
2Birth length less than 3rd percentile (HP:0003561)4.37112155
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.14464719
4Microvesicular hepatic steatosis (HP:0001414)3.80862309
5Abnormality of chromosome stability (HP:0003220)3.46676030
6Volvulus (HP:0002580)3.17831003
7Methylmalonic acidemia (HP:0002912)3.03505283
8Medulloblastoma (HP:0002885)3.02553161
9Myelodysplasia (HP:0002863)2.98718138
1011 pairs of ribs (HP:0000878)2.92305437
11Hyperglycinemia (HP:0002154)2.90607178
12Acute myeloid leukemia (HP:0004808)2.90024067
13Abnormality of the preputium (HP:0100587)2.89874782
14Meckel diverticulum (HP:0002245)2.86287040
15Degeneration of anterior horn cells (HP:0002398)2.82613362
16Abnormality of the anterior horn cell (HP:0006802)2.82613362
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.79147818
18Abnormality of the ileum (HP:0001549)2.77124745
19Patellar aplasia (HP:0006443)2.74759101
20Abnormal number of incisors (HP:0011064)2.63335681
21Nephroblastoma (Wilms tumor) (HP:0002667)2.58203738
22Selective tooth agenesis (HP:0001592)2.58001153
23Acute necrotizing encephalopathy (HP:0006965)2.57514963
24Bone marrow hypocellularity (HP:0005528)2.56415732
25Premature graying of hair (HP:0002216)2.56353984
26Colon cancer (HP:0003003)2.51788374
27Aplasia/Hypoplasia of the patella (HP:0006498)2.50889070
28Duodenal stenosis (HP:0100867)2.48467900
29Small intestinal stenosis (HP:0012848)2.48467900
30Methylmalonic aciduria (HP:0012120)2.47524323
31Aplastic anemia (HP:0001915)2.46581335
32Acute lymphatic leukemia (HP:0006721)2.46027822
33Deep philtrum (HP:0002002)2.45902311
34Increased hepatocellular lipid droplets (HP:0006565)2.45529892
35Acute encephalopathy (HP:0006846)2.45209948
36Oral leukoplakia (HP:0002745)2.45066468
37Embryonal renal neoplasm (HP:0011794)2.44432698
38Optic nerve coloboma (HP:0000588)2.42823293
39Agnosia (HP:0010524)2.38394236
40Ectopic kidney (HP:0000086)2.37719587
41Increased CSF lactate (HP:0002490)2.35304347
42Lipid accumulation in hepatocytes (HP:0006561)2.34436467
43Renal cortical cysts (HP:0000803)2.30464715
44Sloping forehead (HP:0000340)2.28233287
45Triphalangeal thumb (HP:0001199)2.26223533
46Prominent nose (HP:0000448)2.26203331
47Abnormality of serum amino acid levels (HP:0003112)2.23607767
48Rough bone trabeculation (HP:0100670)2.22904416
49Long eyelashes (HP:0000527)2.22049411
50Abnormal trabecular bone morphology (HP:0100671)2.21758685
51Abnormal lung lobation (HP:0002101)2.21178551
52Progressive macrocephaly (HP:0004481)2.21101255
53Abnormal mitochondria in muscle tissue (HP:0008316)2.20264222
54IgM deficiency (HP:0002850)2.19928002
55Abnormality of the astrocytes (HP:0100707)2.19645272
56Astrocytoma (HP:0009592)2.19645272
57Type 2 muscle fiber atrophy (HP:0003554)2.19317081
58Type I transferrin isoform profile (HP:0003642)2.19058123
59Abnormality of methionine metabolism (HP:0010901)2.18948296
60Abnormality of the fingertips (HP:0001211)2.17300953
61Lymphoma (HP:0002665)2.16975040
62Mitochondrial inheritance (HP:0001427)2.16448046
63Increased nuchal translucency (HP:0010880)2.16123377
64Abnormality of the duodenum (HP:0002246)2.15833949
65Cellular immunodeficiency (HP:0005374)2.14412668
66Abnormality of the incisor (HP:0000676)2.14411323
67Reduced antithrombin III activity (HP:0001976)2.14295970
68Thrombocytosis (HP:0001894)2.13361338
69Ependymoma (HP:0002888)2.12582778
70Medial flaring of the eyebrow (HP:0010747)2.11815204
71Neoplasm of the adrenal gland (HP:0100631)2.11752945
72Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09297006
73Clubbing of toes (HP:0100760)2.08385510
74Abnormality of serine family amino acid metabolism (HP:0010894)2.04532394
75Abnormality of glycine metabolism (HP:0010895)2.04532394
76Abnormality of the carotid arteries (HP:0005344)2.02537444
77Abnormality of cells of the erythroid lineage (HP:0012130)2.00352000
78Cortical dysplasia (HP:0002539)1.99369296
79Glioma (HP:0009733)1.99182672
80Rhabdomyosarcoma (HP:0002859)1.99170720
81Abnormality of the renal collecting system (HP:0004742)1.99043901
82Neoplasm of the pancreas (HP:0002894)1.97726402
83Cerebral edema (HP:0002181)1.96088785
84Reticulocytopenia (HP:0001896)1.95904180
85Lip pit (HP:0100267)1.94756651
86Absent thumb (HP:0009777)1.94550615
87Severe visual impairment (HP:0001141)1.94004214
88True hermaphroditism (HP:0010459)1.93986639
89Septo-optic dysplasia (HP:0100842)1.93533330
90Absent radius (HP:0003974)1.92307046
91Increased serum pyruvate (HP:0003542)1.92233252
92Hepatocellular necrosis (HP:0001404)1.92225346
93Facial cleft (HP:0002006)1.91668857
94Genital tract atresia (HP:0001827)1.90350542
95Oligodactyly (hands) (HP:0001180)1.89381958
96Gastrointestinal atresia (HP:0002589)1.89265053
97Muscle fiber atrophy (HP:0100295)1.87552341
98Congenital primary aphakia (HP:0007707)1.87196229
99Small hand (HP:0200055)1.86981802
100Breast hypoplasia (HP:0003187)1.86746754
101Impulsivity (HP:0100710)1.86659016
102Aplasia involving forearm bones (HP:0009822)1.86656530
103Absent forearm bone (HP:0003953)1.86656530
104Increased serum lactate (HP:0002151)1.86296068
105Horseshoe kidney (HP:0000085)1.85684974
106Hepatic necrosis (HP:0002605)1.84451187
107Abnormality of the labia minora (HP:0012880)1.83808992
108Abnormality of DNA repair (HP:0003254)1.83507338
109Vaginal atresia (HP:0000148)1.83345149
110Molar tooth sign on MRI (HP:0002419)1.83030429
111Abnormality of midbrain morphology (HP:0002418)1.83030429
112Abnormal spermatogenesis (HP:0008669)1.81657166
113Aseptic necrosis (HP:0010885)1.81456923
114Abnormality of the prostate (HP:0008775)1.81247029
115Basal cell carcinoma (HP:0002671)1.80994771
116Deviation of the thumb (HP:0009603)1.80204488
117Papillary thyroid carcinoma (HP:0002895)1.79807583
118Abnormality of the columella (HP:0009929)1.79796118
119Amaurosis fugax (HP:0100576)1.79563529
120Proximal placement of thumb (HP:0009623)1.78981457
121Neoplasm of the colon (HP:0100273)1.78742406
122Short 4th metacarpal (HP:0010044)1.78695330
123Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78695330
124Pancreatic islet-cell hyperplasia (HP:0004510)1.77845597
125Abnormality of glycolysis (HP:0004366)1.77823956
126Abnormality of the vitamin B12 metabolism (HP:0004341)1.77476402
127Gait imbalance (HP:0002141)1.76081764
128B lymphocytopenia (HP:0010976)1.75053785
129Abnormality of B cell number (HP:0010975)1.75053785
130Duplicated collecting system (HP:0000081)1.74476782
131Postnatal microcephaly (HP:0005484)1.73829904
132Abnormality of vitamin B metabolism (HP:0004340)1.73643619
133Multiple enchondromatosis (HP:0005701)1.73331373
134Bifid tongue (HP:0010297)1.73132086
135Astigmatism (HP:0000483)1.72551606
136Pancreatic fibrosis (HP:0100732)1.72504156
137Nephrogenic diabetes insipidus (HP:0009806)1.72173858
138Broad palm (HP:0001169)1.72126698
139Cafe-au-lait spot (HP:0000957)1.71488560
140Abnormal hair whorl (HP:0010721)1.70904322
141Stenosis of the external auditory canal (HP:0000402)1.70237624
142Supernumerary spleens (HP:0009799)1.70147057
143Neoplasm of the oral cavity (HP:0100649)1.69516043
144Tracheoesophageal fistula (HP:0002575)1.69474062
145Abnormal protein glycosylation (HP:0012346)1.68986152
146Abnormal glycosylation (HP:0012345)1.68986152
147Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.68986152
148Abnormal protein N-linked glycosylation (HP:0012347)1.68986152
149Long clavicles (HP:0000890)1.68350048
150Ovarian neoplasm (HP:0100615)1.66754231
151Intestinal atresia (HP:0011100)1.66465114
152Absent septum pellucidum (HP:0001331)1.66449432
153Pancreatic cysts (HP:0001737)1.65526586
154Carpal bone hypoplasia (HP:0001498)1.65480349
155Nephronophthisis (HP:0000090)1.65075148
156Capillary hemangiomas (HP:0005306)1.64113888
157Clitoromegaly (HP:0000057)1.63968170
158Short tibia (HP:0005736)1.63731807
159Dandy-Walker malformation (HP:0001305)1.63665141
160Esophageal atresia (HP:0002032)1.63486551
161Hypoplastic pelvis (HP:0008839)1.63086839
162Abnormality of the renal cortex (HP:0011035)1.62835014
163Alveolar cell carcinoma (HP:0006519)1.62606018
164Atresia of the external auditory canal (HP:0000413)1.62588127
165Abnormality of the clitoris (HP:0000056)1.61066550
166High pitched voice (HP:0001620)1.60533714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.34951732
2EIF2AK14.27973637
3BUB13.59222991
4TRIM283.11535847
5EIF2AK33.06451759
6WNK32.99360011
7SRPK12.91584144
8WEE12.71804821
9PLK42.71407881
10ZAK2.57043113
11MST42.47140269
12BRSK22.45685818
13ACVR1B2.27969608
14NEK22.13630450
15STK162.12728657
16ATR2.03421111
17PBK2.01545586
18MKNK11.95482142
19TTK1.95464896
20EIF2AK21.85061870
21VRK11.81624737
22TSSK61.79003876
23MKNK21.75244311
24NEK11.68440184
25BCR1.62644533
26CCNB11.61252333
27PLK31.60217100
28MAP4K21.59767923
29PLK11.54653020
30BRSK11.54245977
31PLK21.54108549
32CHEK21.51060701
33TXK1.44248092
34ERBB31.42901304
35AURKB1.42785827
36BRD41.40060645
37FLT31.36312526
38SIK31.33619254
39PASK1.32273777
40DYRK31.31912821
41TEC1.28814613
42VRK21.26589380
43CDK71.26443768
44RPS6KA41.25904987
45RPS6KB21.24584120
46PNCK1.22160388
47MAP3K41.13144949
48CHEK11.11692432
49CDK121.07135900
50CSNK1G11.07127061
51ATM1.06924248
52TGFBR11.05388433
53CDK81.03809176
54STK38L1.01838722
55CASK0.97403640
56AKT30.97169428
57NME10.95049105
58TAF10.94172206
59CSNK1G30.91366968
60CSNK1G20.88253235
61CDK40.88147184
62MAP4K10.85747750
63MAPK130.83306193
64ERBB40.80802052
65OXSR10.79091889
66DYRK20.78561834
67YES10.78341365
68CSNK1A1L0.78189125
69CDK60.76596780
70STK40.76457297
71GRK10.75624095
72AURKA0.74427855
73IRAK40.73960164
74CDK20.71274200
75STK100.70044827
76PDK20.69079218
77STK390.67600324
78NEK90.66374620
79SGK20.66299970
80BRAF0.65295515
81RPS6KB10.64721878
82BTK0.64623176
83SCYL20.64214692
84PAK30.63920064
85PIM10.63877960
86CDK10.62256157
87MAP2K70.61019730
88BCKDK0.59955643
89CAMK1D0.59841115
90NUAK10.57944734
91OBSCN0.57594278
92FGFR20.57482216
93STK30.56815287
94TLK10.55993437
95KIT0.55435484
96CSNK2A10.54407029
97MAP3K80.53881772
98STK240.53240987
99JAK30.53065615
100CLK10.51559200
101PRKCG0.50992651
102EPHA40.50844041
103MELK0.49797396
104INSRR0.49744182
105MINK10.49700546
106PINK10.49201326
107CDK90.48907307
108CDK30.48647007
109CSNK2A20.46956521
110CSF1R0.46471352
111TYK20.45217248
112CSNK1E0.44095562
113TNIK0.44017986
114NME20.43228163
115ITK0.42402004
116IRAK30.41967921
117TAOK20.40624183
118NLK0.40560089
119WNK40.39094074
120PRKDC0.37641949
121LATS10.37021411
122PRKCE0.36518514
123CAMKK20.35480254
124ZAP700.35077389
125CHUK0.34314712
126SGK30.33743188
127MAPK140.32971494
128RPS6KA50.31957194
129SYK0.30850506
130CDK190.29977578
131CSNK1A10.27683286
132ADRBK20.26827552
133ALK0.26510826
134KSR10.26274130
135AKT10.26085298
136BMPR1B0.25961927
137FGFR10.25654950
138EEF2K0.25582817
139LYN0.25335662
140FRK0.24958043
141NEK60.24158966

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.80894825
2Mismatch repair_Homo sapiens_hsa034304.39880623
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.58841582
4Homologous recombination_Homo sapiens_hsa034403.53843586
5Non-homologous end-joining_Homo sapiens_hsa034503.13391048
6* Cell cycle_Homo sapiens_hsa041102.93168527
7Base excision repair_Homo sapiens_hsa034102.92713219
8RNA polymerase_Homo sapiens_hsa030202.90266789
9RNA transport_Homo sapiens_hsa030132.85499607
10Fanconi anemia pathway_Homo sapiens_hsa034602.84711062
11Spliceosome_Homo sapiens_hsa030402.83499995
12Nucleotide excision repair_Homo sapiens_hsa034202.71336980
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.70256182
14One carbon pool by folate_Homo sapiens_hsa006702.66127195
15Proteasome_Homo sapiens_hsa030502.60830461
16Propanoate metabolism_Homo sapiens_hsa006402.39763142
17Pyrimidine metabolism_Homo sapiens_hsa002402.35334080
18RNA degradation_Homo sapiens_hsa030182.31379330
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.14433138
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03174531
21Ribosome_Homo sapiens_hsa030101.93784424
22Basal transcription factors_Homo sapiens_hsa030221.89721302
23mRNA surveillance pathway_Homo sapiens_hsa030151.70656796
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68543874
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67816043
26Oxidative phosphorylation_Homo sapiens_hsa001901.66751981
27p53 signaling pathway_Homo sapiens_hsa041151.66438555
28Parkinsons disease_Homo sapiens_hsa050121.56360319
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55409505
30Pyruvate metabolism_Homo sapiens_hsa006201.54208555
31Steroid biosynthesis_Homo sapiens_hsa001001.53097994
32Fatty acid elongation_Homo sapiens_hsa000621.51774337
33Purine metabolism_Homo sapiens_hsa002301.47515091
34Vitamin B6 metabolism_Homo sapiens_hsa007501.40521837
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33085467
36Epstein-Barr virus infection_Homo sapiens_hsa051691.24567831
37Herpes simplex infection_Homo sapiens_hsa051681.24484391
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22443826
39Systemic lupus erythematosus_Homo sapiens_hsa053221.22213148
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21432200
41Huntingtons disease_Homo sapiens_hsa050161.13705200
42Butanoate metabolism_Homo sapiens_hsa006501.10458331
43Carbon metabolism_Homo sapiens_hsa012001.07954668
44Protein export_Homo sapiens_hsa030601.04452427
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03046246
46Viral carcinogenesis_Homo sapiens_hsa052030.96041872
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89490715
48Primary immunodeficiency_Homo sapiens_hsa053400.88673526
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85568542
50Antigen processing and presentation_Homo sapiens_hsa046120.85130745
51HTLV-I infection_Homo sapiens_hsa051660.84849756
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84842604
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84499042
54Glutathione metabolism_Homo sapiens_hsa004800.83858770
55Selenocompound metabolism_Homo sapiens_hsa004500.80973119
56Alzheimers disease_Homo sapiens_hsa050100.80745688
57Peroxisome_Homo sapiens_hsa041460.79024058
58Fatty acid metabolism_Homo sapiens_hsa012120.78559172
59Oocyte meiosis_Homo sapiens_hsa041140.77884413
60Measles_Homo sapiens_hsa051620.74062296
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73321815
62Phototransduction_Homo sapiens_hsa047440.72552248
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.70979349
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69444378
65Thyroid cancer_Homo sapiens_hsa052160.69000027
66N-Glycan biosynthesis_Homo sapiens_hsa005100.66801380
67Metabolic pathways_Homo sapiens_hsa011000.65014483
68MicroRNAs in cancer_Homo sapiens_hsa052060.63679132
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63167810
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.59892329
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58919684
72Fatty acid degradation_Homo sapiens_hsa000710.58710919
73Hematopoietic cell lineage_Homo sapiens_hsa046400.54763697
74Legionellosis_Homo sapiens_hsa051340.54382354
75Small cell lung cancer_Homo sapiens_hsa052220.52091645
76Nitrogen metabolism_Homo sapiens_hsa009100.51688694
77Pentose phosphate pathway_Homo sapiens_hsa000300.51494941
78Colorectal cancer_Homo sapiens_hsa052100.50939142
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.50767498
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50692880
81Hepatitis B_Homo sapiens_hsa051610.50449490
82Alcoholism_Homo sapiens_hsa050340.49754777
83beta-Alanine metabolism_Homo sapiens_hsa004100.48889061
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47881253
85Biosynthesis of amino acids_Homo sapiens_hsa012300.47525293
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47169427
87Influenza A_Homo sapiens_hsa051640.46057772
88Tryptophan metabolism_Homo sapiens_hsa003800.45888461
89Apoptosis_Homo sapiens_hsa042100.44075871
90Nicotine addiction_Homo sapiens_hsa050330.43432414
91Lysine degradation_Homo sapiens_hsa003100.43111184
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41706788
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.41613534
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.41526278
95Arginine and proline metabolism_Homo sapiens_hsa003300.41051111
96Cardiac muscle contraction_Homo sapiens_hsa042600.40974845
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40577971
98Hedgehog signaling pathway_Homo sapiens_hsa043400.38333659
99Sulfur metabolism_Homo sapiens_hsa009200.37340901
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36931537
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.36914986
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36551168
103Acute myeloid leukemia_Homo sapiens_hsa052210.35981612
104Hippo signaling pathway_Homo sapiens_hsa043900.35021344
105Retinol metabolism_Homo sapiens_hsa008300.34968928
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34522585
107Circadian rhythm_Homo sapiens_hsa047100.34443188
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34202031
109Caffeine metabolism_Homo sapiens_hsa002320.33695294
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33609371
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33519476
112Folate biosynthesis_Homo sapiens_hsa007900.32343769
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31311295
114Chronic myeloid leukemia_Homo sapiens_hsa052200.31128888
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31049663
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30955713
117Basal cell carcinoma_Homo sapiens_hsa052170.30857728
118Olfactory transduction_Homo sapiens_hsa047400.30614913
119TGF-beta signaling pathway_Homo sapiens_hsa043500.29341763
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29027305
121Non-small cell lung cancer_Homo sapiens_hsa052230.28437697
122HIF-1 signaling pathway_Homo sapiens_hsa040660.27163140
123Galactose metabolism_Homo sapiens_hsa000520.26983346
124FoxO signaling pathway_Homo sapiens_hsa040680.26734999
125Fructose and mannose metabolism_Homo sapiens_hsa000510.26470982
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25978922
127Pathways in cancer_Homo sapiens_hsa052000.25884923
128Taste transduction_Homo sapiens_hsa047420.25523002
129Renin-angiotensin system_Homo sapiens_hsa046140.25297799
130Regulation of autophagy_Homo sapiens_hsa041400.24079779
131Prostate cancer_Homo sapiens_hsa052150.22328378
132mTOR signaling pathway_Homo sapiens_hsa041500.22072822
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.21579837
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.21417690
135Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21384007
136Type I diabetes mellitus_Homo sapiens_hsa049400.20929052
137T cell receptor signaling pathway_Homo sapiens_hsa046600.20831378
138Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20816061
139Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19976216
140Collecting duct acid secretion_Homo sapiens_hsa049660.19909046
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19565929
142B cell receptor signaling pathway_Homo sapiens_hsa046620.18703371
143Endometrial cancer_Homo sapiens_hsa052130.17501642
144Pancreatic cancer_Homo sapiens_hsa052120.17281702
145Other glycan degradation_Homo sapiens_hsa005110.16592775
146Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16579872
147Allograft rejection_Homo sapiens_hsa053300.16150204
148Shigellosis_Homo sapiens_hsa051310.15752303
149Vitamin digestion and absorption_Homo sapiens_hsa049770.15553404
150Wnt signaling pathway_Homo sapiens_hsa043100.14997029
151Ether lipid metabolism_Homo sapiens_hsa005650.14265598
152Chemical carcinogenesis_Homo sapiens_hsa052040.13422088
153Cyanoamino acid metabolism_Homo sapiens_hsa004600.12544796
154Viral myocarditis_Homo sapiens_hsa054160.10801450

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