ORC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1CENP-A containing nucleosome assembly (GO:0034080)4.73615544
2chromatin remodeling at centromere (GO:0031055)4.60709327
3mitotic metaphase plate congression (GO:0007080)4.48324237
4DNA double-strand break processing (GO:0000729)4.31865131
5rRNA modification (GO:0000154)4.19959806
6protein K6-linked ubiquitination (GO:0085020)4.14611090
7rRNA methylation (GO:0031167)4.12310299
8sister chromatid segregation (GO:0000819)4.06402323
9pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.04278417
10metaphase plate congression (GO:0051310)4.03242366
11kinetochore organization (GO:0051383)4.02345745
12piRNA metabolic process (GO:0034587)4.02070363
13proteasome assembly (GO:0043248)4.01131431
14DNA replication-independent nucleosome organization (GO:0034724)3.95161258
15DNA replication-independent nucleosome assembly (GO:0006336)3.95161258
16kinetochore assembly (GO:0051382)3.89538494
17maturation of 5.8S rRNA (GO:0000460)3.88152517
18purine nucleobase biosynthetic process (GO:0009113)3.86123662
19histone exchange (GO:0043486)3.83376547
20telomere maintenance via semi-conservative replication (GO:0032201)3.82558154
21attachment of spindle microtubules to kinetochore (GO:0008608)3.76295155
22DNA replication checkpoint (GO:0000076)3.75594289
23telomere maintenance via recombination (GO:0000722)3.74232162
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.73037742
25DNA strand elongation involved in DNA replication (GO:0006271)3.72373317
26meiotic chromosome segregation (GO:0045132)3.71863906
27* DNA replication initiation (GO:0006270)3.70495701
28regulation of centriole replication (GO:0046599)3.65783096
297-methylguanosine mRNA capping (GO:0006370)3.65757678
30DNA strand elongation (GO:0022616)3.60556304
31nucleobase biosynthetic process (GO:0046112)3.59585442
32RNA capping (GO:0036260)3.58426563
337-methylguanosine RNA capping (GO:0009452)3.58426563
34base-excision repair, AP site formation (GO:0006285)3.58078825
35establishment of chromosome localization (GO:0051303)3.57672335
36DNA methylation involved in gamete generation (GO:0043046)3.52607332
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.52556557
38negative regulation of ligase activity (GO:0051352)3.52556557
39establishment of integrated proviral latency (GO:0075713)3.52274989
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.47982917
41pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.43824791
42mitotic recombination (GO:0006312)3.43391195
43DNA deamination (GO:0045006)3.42098099
44microtubule depolymerization (GO:0007019)3.42066590
45mitotic sister chromatid cohesion (GO:0007064)3.41985345
46DNA catabolic process, exonucleolytic (GO:0000738)3.40714674
47transcription-coupled nucleotide-excision repair (GO:0006283)3.40658950
48telomere maintenance via telomere lengthening (GO:0010833)3.40248240
49negative regulation of DNA-dependent DNA replication (GO:2000104)3.39650801
50synapsis (GO:0007129)3.38030792
51transcription from mitochondrial promoter (GO:0006390)3.36873636
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.34121254
53transcription elongation from RNA polymerase I promoter (GO:0006362)3.33912345
54regulation of chromosome segregation (GO:0051983)3.33884150
55non-recombinational repair (GO:0000726)3.32610840
56double-strand break repair via nonhomologous end joining (GO:0006303)3.32610840
57pyrimidine nucleotide catabolic process (GO:0006244)3.29153574
58respiratory chain complex IV assembly (GO:0008535)3.26816151
59termination of RNA polymerase I transcription (GO:0006363)3.26776576
60nucleotide-excision repair, DNA gap filling (GO:0006297)3.24195752
61transcription elongation from RNA polymerase III promoter (GO:0006385)3.21481078
62termination of RNA polymerase III transcription (GO:0006386)3.21481078
63mitotic nuclear envelope disassembly (GO:0007077)3.20614732
64IMP biosynthetic process (GO:0006188)3.19733111
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19581003
66positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.18691702
67protein deneddylation (GO:0000338)3.18499320
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17882186
69regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15580634
70regulation of mitotic spindle checkpoint (GO:1903504)3.15580634
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.14971837
72signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.14971837
73signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.14971837
74mismatch repair (GO:0006298)3.14015851
75DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.12619172
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11878752
77tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11878752
78signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.11738686
79intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.11738686
80spindle checkpoint (GO:0031577)3.11060672
81nuclear pore complex assembly (GO:0051292)3.10429220
82maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.09924651
83regulation of DNA endoreduplication (GO:0032875)3.08944847
84tRNA aminoacylation (GO:0043039)3.08227893
85amino acid activation (GO:0043038)3.08227893
86tRNA aminoacylation for protein translation (GO:0006418)3.07576811
87positive regulation of ligase activity (GO:0051351)3.07235265
88nuclear pore organization (GO:0006999)3.06820950
89regulation of cellular amino acid metabolic process (GO:0006521)3.06732284
90signal transduction involved in DNA damage checkpoint (GO:0072422)3.05603849
91signal transduction involved in DNA integrity checkpoint (GO:0072401)3.05603849
92regulation of telomere maintenance via telomerase (GO:0032210)3.04430171
93resolution of meiotic recombination intermediates (GO:0000712)3.04300154
94spliceosomal complex assembly (GO:0000245)3.03074115
95signal transduction involved in cell cycle checkpoint (GO:0072395)3.02224052
96chromosome segregation (GO:0007059)3.01405957
97centriole replication (GO:0007099)3.01397487
98regulation of meiosis I (GO:0060631)3.01372544
99positive regulation of chromosome segregation (GO:0051984)3.00917053
100cullin deneddylation (GO:0010388)3.00171896
101negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.99743901
102transcription from RNA polymerase I promoter (GO:0006360)2.95928758
103protein localization to kinetochore (GO:0034501)2.95563151
104negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95095434
105negative regulation of sister chromatid segregation (GO:0033046)2.95095434
106negative regulation of mitotic sister chromatid separation (GO:2000816)2.95095434
107negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95095434
108anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95044527
109spliceosomal snRNP assembly (GO:0000387)2.95000396
110somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.94165978
111somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.94165978
112isotype switching (GO:0045190)2.94165978
113RNA methylation (GO:0001510)2.94082490
114negative regulation of telomere maintenance (GO:0032205)2.93415096
115mitotic spindle checkpoint (GO:0071174)2.92080021
116mitotic sister chromatid segregation (GO:0000070)2.90545939
117DNA ligation (GO:0006266)2.90232369
118regulation of double-strand break repair via homologous recombination (GO:0010569)2.90201935
119negative regulation of chromosome segregation (GO:0051985)2.89879094
120DNA replication-dependent nucleosome assembly (GO:0006335)2.89180827
121DNA replication-dependent nucleosome organization (GO:0034723)2.89180827
122viral mRNA export from host cell nucleus (GO:0046784)2.89169152
123rRNA processing (GO:0006364)2.88594030
124transcription initiation from RNA polymerase I promoter (GO:0006361)2.87200870
125spindle assembly checkpoint (GO:0071173)2.87073842
126regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.86597903
127regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.85987930
128somatic hypermutation of immunoglobulin genes (GO:0016446)2.85696304
129somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85696304
130regulation of nuclear cell cycle DNA replication (GO:0033262)2.85684592
131replication fork processing (GO:0031297)2.84694122
132regulation of mitotic sister chromatid separation (GO:0010965)2.84114610
133regulation of mitotic sister chromatid segregation (GO:0033047)2.84114610
134regulation of sister chromatid segregation (GO:0033045)2.84114610
135mitotic spindle assembly checkpoint (GO:0007094)2.84011143
136L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.83541781
137nucleotide-excision repair (GO:0006289)2.83004695
138deoxyribonucleotide biosynthetic process (GO:0009263)2.82717584
139regulation of mitotic metaphase/anaphase transition (GO:0030071)2.82100595
140ribosome assembly (GO:0042255)2.81886676
141DNA synthesis involved in DNA repair (GO:0000731)2.81275564
142negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80699319
143protein localization to chromosome, centromeric region (GO:0071459)2.79692662

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.57164538
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.11928408
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.49601342
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.34509016
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.26594538
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.26508907
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.20656084
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.18032403
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00974712
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84223500
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.67076079
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.62941314
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.60664965
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.58280479
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54740238
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54614540
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49007704
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41943651
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36046748
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33580486
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31773029
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29766499
23VDR_23849224_ChIP-Seq_CD4+_Human2.25903927
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17386270
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.15306240
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06334906
27FOXP3_21729870_ChIP-Seq_TREG_Human1.95106986
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.90640465
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85566375
30ELK1_19687146_ChIP-ChIP_HELA_Human1.84944562
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83139594
32* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77606770
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75065983
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75009633
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.74285350
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73024647
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.70904879
38IRF1_19129219_ChIP-ChIP_H3396_Human1.69923801
39DCP1A_22483619_ChIP-Seq_HELA_Human1.69921597
40TTF2_22483619_ChIP-Seq_HELA_Human1.66650919
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62570707
42MYC_18940864_ChIP-ChIP_HL60_Human1.62012250
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60791493
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60210913
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.60018587
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59476388
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.55848319
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54072548
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53297064
50XRN2_22483619_ChIP-Seq_HELA_Human1.50703843
51GABP_19822575_ChIP-Seq_HepG2_Human1.48773518
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48104199
53KAP1_22055183_ChIP-Seq_ESCs_Mouse1.44496119
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.43237607
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40713979
56AR_21909140_ChIP-Seq_LNCAP_Human1.40681910
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39943137
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39895948
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34799823
60ZNF274_21170338_ChIP-Seq_K562_Hela1.34784785
61ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.32114194
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.30552767
63* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27099030
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25677396
65VDR_22108803_ChIP-Seq_LS180_Human1.25552521
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21373702
67EWS_26573619_Chip-Seq_HEK293_Human1.17971147
68CIITA_25753668_ChIP-Seq_RAJI_Human1.17305175
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.16075872
70FUS_26573619_Chip-Seq_HEK293_Human1.13485025
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12037322
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.09877359
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09701899
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09685705
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07919764
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07464486
77NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.06372024
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.06231572
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06134629
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05093939
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01951836
82RNF2_27304074_Chip-Seq_NSC_Mouse1.00625043
83SOX17_20123909_ChIP-Seq_XEN_Mouse0.99146665
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98826878
85PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92137276
86BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90623184
87P300_19829295_ChIP-Seq_ESCs_Human0.90449460
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89983940
89CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89646677
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89240642
91EZH2_27294783_Chip-Seq_NPCs_Mouse0.88565513
92ELK1_22589737_ChIP-Seq_MCF10A_Human0.88300437
93GATA1_26923725_Chip-Seq_HPCs_Mouse0.86852686
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.86805488
95TFEB_21752829_ChIP-Seq_HELA_Human0.86715151
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85849814
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.85638880
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84074283
99TAF15_26573619_Chip-Seq_HEK293_Human0.83645926
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83181309
101EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.82135317
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82000184
103NMYC_18555785_Chip-Seq_ESCs_Mouse0.81067675
104KDM5A_27292631_Chip-Seq_BREAST_Human0.80558239
105GBX2_23144817_ChIP-Seq_PC3_Human0.80448658
106ELF5_23300383_ChIP-Seq_T47D_Human0.80145749
107CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79141937
108IGF1R_20145208_ChIP-Seq_DFB_Human0.78274762
109KLF4_18555785_Chip-Seq_ESCs_Mouse0.77923917
110ZFX_18555785_Chip-Seq_ESCs_Mouse0.77865899
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77618996
112KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.77618996
113KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77618996
114P300_18555785_Chip-Seq_ESCs_Mouse0.77490743
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76354284
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.74008670
117TP53_22573176_ChIP-Seq_HFKS_Human0.72294347
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.71699692
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.71259120
120BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.71152753
121SALL4_22934838_ChIP-ChIP_CD34+_Human0.71120447
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.70600128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.22250165
2MP0003693_abnormal_embryo_hatching4.09860282
3MP0003718_maternal_effect3.71750626
4MP0006292_abnormal_olfactory_placode3.66090836
5MP0008058_abnormal_DNA_repair3.63020016
6MP0003111_abnormal_nucleus_morphology3.54537887
7MP0000372_irregular_coat_pigmentation3.47014256
8MP0008057_abnormal_DNA_replication3.42650329
9MP0008877_abnormal_DNA_methylation3.33465070
10MP0004957_abnormal_blastocyst_morpholog3.17997991
11MP0002102_abnormal_ear_morphology3.09820085
12MP0003077_abnormal_cell_cycle2.97851426
13MP0008932_abnormal_embryonic_tissue2.61389212
14MP0003136_yellow_coat_color2.33552978
15MP0000566_synostosis2.20823680
16MP0001188_hyperpigmentation2.01954008
17MP0005451_abnormal_body_composition1.98818332
18MP0003786_premature_aging1.98006334
19MP0008007_abnormal_cellular_replicative1.92892213
20MP0009697_abnormal_copulation1.89317459
21MP0004147_increased_porphyrin_level1.82509176
22MP0001986_abnormal_taste_sensitivity1.79751280
23MP0002210_abnormal_sex_determination1.74628590
24MP0001929_abnormal_gametogenesis1.73908739
25MP0001529_abnormal_vocalization1.69785420
26MP0006035_abnormal_mitochondrial_morpho1.68469360
27MP0006072_abnormal_retinal_apoptosis1.65067873
28MP0003315_abnormal_perineum_morphology1.62087460
29MP0006036_abnormal_mitochondrial_physio1.57341509
30MP0005646_abnormal_pituitary_gland1.57217434
31MP0003806_abnormal_nucleotide_metabolis1.55653450
32MP0000653_abnormal_sex_gland1.53755441
33MP0001293_anophthalmia1.48853459
34MP0001119_abnormal_female_reproductive1.46176732
35MP0000015_abnormal_ear_pigmentation1.43812062
36MP0010307_abnormal_tumor_latency1.43225151
37MP0008260_abnormal_autophagy1.43182976
38MP0002277_abnormal_respiratory_mucosa1.42543826
39MP0004133_heterotaxia1.42498099
40MP0001145_abnormal_male_reproductive1.40228479
41MP0003890_abnormal_embryonic-extraembry1.39078427
42MP0002132_abnormal_respiratory_system1.36196036
43MP0002396_abnormal_hematopoietic_system1.28877623
44MP0001905_abnormal_dopamine_level1.28551703
45MP0002160_abnormal_reproductive_system1.27394897
46MP0000358_abnormal_cell_content/1.22761072
47MP0005379_endocrine/exocrine_gland_phen1.22303942
48MP0001485_abnormal_pinna_reflex1.21114567
49MP0010030_abnormal_orbit_morphology1.20581857
50MP0005389_reproductive_system_phenotype1.19456821
51MP0002938_white_spotting1.18939114
52MP0002234_abnormal_pharynx_morphology1.17080950
53MP0002090_abnormal_vision1.15436327
54MP0003699_abnormal_female_reproductive1.14088788
55MP0004381_abnormal_hair_follicle1.14045554
56MP0003121_genomic_imprinting1.13361064
57MP0003195_calcinosis1.12877701
58MP0003123_paternal_imprinting1.10418235
59MP0000350_abnormal_cell_proliferation1.10398402
60MP0005408_hypopigmentation1.10270072
61MP0008789_abnormal_olfactory_epithelium1.09826392
62MP0003763_abnormal_thymus_physiology1.09169439
63MP0002095_abnormal_skin_pigmentation1.07398015
64MP0003698_abnormal_male_reproductive1.06583677
65MP0005075_abnormal_melanosome_morpholog1.06390295
66MP0005395_other_phenotype1.06091584
67MP0003787_abnormal_imprinting1.06028634
68MP0005171_absent_coat_pigmentation1.05838323
69MP0000490_abnormal_crypts_of1.05332926
70MP0008995_early_reproductive_senescence1.05092396
71MP0002249_abnormal_larynx_morphology1.03513575
72MP0003937_abnormal_limbs/digits/tail_de1.02457456
73MP0002080_prenatal_lethality1.01974300
74MP0001919_abnormal_reproductive_system0.99675670
75MP0000313_abnormal_cell_death0.97841905
76MP0002161_abnormal_fertility/fecundity0.93440493
77MP0003984_embryonic_growth_retardation0.92984253
78MP0002088_abnormal_embryonic_growth/wei0.92282316
79MP0003941_abnormal_skin_development0.91336781
80MP0001730_embryonic_growth_arrest0.91057609
81MP0000026_abnormal_inner_ear0.90215257
82MP0003943_abnormal_hepatobiliary_system0.89739724
83MP0003938_abnormal_ear_development0.89716988
84MP0005174_abnormal_tail_pigmentation0.88143268
85MP0000631_abnormal_neuroendocrine_gland0.87539090
86MP0004142_abnormal_muscle_tone0.87488543
87MP0000647_abnormal_sebaceous_gland0.87142873
88MP0002085_abnormal_embryonic_tissue0.85446428
89MP0001324_abnormal_eye_pigmentation0.84743959
90MP0005499_abnormal_olfactory_system0.83227926
91MP0005394_taste/olfaction_phenotype0.83227926
92MP0000613_abnormal_salivary_gland0.82462322
93MP0003950_abnormal_plasma_membrane0.82431590
94MP0003646_muscle_fatigue0.80029418
95MP0009379_abnormal_foot_pigmentation0.79436232
96MP0000427_abnormal_hair_cycle0.78543467
97MP0002019_abnormal_tumor_incidence0.77485931
98MP0009672_abnormal_birth_weight0.77166758
99MP0002638_abnormal_pupillary_reflex0.77152439
100MP0002282_abnormal_trachea_morphology0.76999790
101MP0001697_abnormal_embryo_size0.76709483
102MP0003119_abnormal_digestive_system0.76420318
103MP0002233_abnormal_nose_morphology0.74715488
104MP0001963_abnormal_hearing_physiology0.73502048
105MP0002751_abnormal_autonomic_nervous0.73246636
106MP0002177_abnormal_outer_ear0.72628226
107MP0003567_abnormal_fetal_cardiomyocyte0.72397175
108MP0000371_diluted_coat_color0.72110019
109MP0001984_abnormal_olfaction0.71780678
110MP0001286_abnormal_eye_development0.70848660
111MP0000678_abnormal_parathyroid_gland0.70606712
112MP0005551_abnormal_eye_electrophysiolog0.70202831
113MP0003880_abnormal_central_pattern0.70091377
114MP0001186_pigmentation_phenotype0.69253239
115MP0003186_abnormal_redox_activity0.68501846
116MP0001672_abnormal_embryogenesis/_devel0.68372393
117MP0005380_embryogenesis_phenotype0.68372393
118MP0009703_decreased_birth_body0.67426922
119MP0001764_abnormal_homeostasis0.67170425
120MP0005253_abnormal_eye_physiology0.67120374
121MP0005423_abnormal_somatic_nervous0.67047390
122MP0005410_abnormal_fertilization0.66710869
123MP0010234_abnormal_vibrissa_follicle0.66635875
124MP0001727_abnormal_embryo_implantation0.66368153
125MP0001661_extended_life_span0.65506485
126MP0000569_abnormal_digit_pigmentation0.65305896
127MP0000462_abnormal_digestive_system0.64945637
128MP0004197_abnormal_fetal_growth/weight/0.64515818
129MP0000049_abnormal_middle_ear0.64183170
130MP0002111_abnormal_tail_morphology0.63964525
131MP0002084_abnormal_developmental_patter0.61951502
132MP0009333_abnormal_splenocyte_physiolog0.61644352
133MP0002163_abnormal_gland_morphology0.60845053
134MP0002653_abnormal_ependyma_morphology0.60841530
135MP0002086_abnormal_extraembryonic_tissu0.60385255
136MP0002736_abnormal_nociception_after0.59229638
137MP0005391_vision/eye_phenotype0.57866059
138MP0010678_abnormal_skin_adnexa0.56883311
139MP0001177_atelectasis0.55696908

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.74352696
2Chromsome breakage (HP:0040012)5.56758709
3Birth length less than 3rd percentile (HP:0003561)5.52579051
4Breast hypoplasia (HP:0003187)3.92812581
5Duplicated collecting system (HP:0000081)3.79964540
6Abnormality of the preputium (HP:0100587)3.56827912
7Abnormality of the renal collecting system (HP:0004742)3.46164860
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.32232311
9Meckel diverticulum (HP:0002245)3.31931801
10Abnormality of methionine metabolism (HP:0010901)3.25186207
11Abnormality of the ileum (HP:0001549)3.19071452
12Abnormality of chromosome stability (HP:0003220)3.18800786
13Reticulocytopenia (HP:0001896)3.09827052
14Acute encephalopathy (HP:0006846)2.97633898
15Supernumerary spleens (HP:0009799)2.89913095
16Patellar aplasia (HP:0006443)2.80331138
17Small intestinal stenosis (HP:0012848)2.79663277
18Duodenal stenosis (HP:0100867)2.79663277
19Volvulus (HP:0002580)2.77707242
20Nephroblastoma (Wilms tumor) (HP:0002667)2.75571936
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.74483957
22Abnormality of alanine metabolism (HP:0010916)2.74483957
23Hyperalaninemia (HP:0003348)2.74483957
24Abnormality of aspartate family amino acid metabolism (HP:0010899)2.70703162
25Absent radius (HP:0003974)2.69811505
26Aplastic anemia (HP:0001915)2.67466881
27Oral leukoplakia (HP:0002745)2.59180959
28Abnormality of the labia minora (HP:0012880)2.58557168
29Progressive macrocephaly (HP:0004481)2.57810675
30Aplasia involving forearm bones (HP:0009822)2.57532860
31Absent forearm bone (HP:0003953)2.57532860
32Aplasia/Hypoplasia of the patella (HP:0006498)2.56674542
333-Methylglutaconic aciduria (HP:0003535)2.55817228
34Abnormal mitochondria in muscle tissue (HP:0008316)2.55238537
35Abnormality of DNA repair (HP:0003254)2.53867020
36Embryonal renal neoplasm (HP:0011794)2.53764404
37Gonadotropin excess (HP:0000837)2.53450175
38Type 2 muscle fiber atrophy (HP:0003554)2.51243529
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.49372282
40Increased serum pyruvate (HP:0003542)2.49271219
41Abnormality of glycolysis (HP:0004366)2.49271219
42Bone marrow hypocellularity (HP:0005528)2.47988652
43Cerebral hypomyelination (HP:0006808)2.46531152
44Clubbing of toes (HP:0100760)2.41845850
45Abnormal lung lobation (HP:0002101)2.40489195
46Microvesicular hepatic steatosis (HP:0001414)2.40338314
47Aplasia/Hypoplasia of the fovea (HP:0008060)2.36320927
48Hypoplasia of the fovea (HP:0007750)2.36320927
49Abnormality of the duodenum (HP:0002246)2.35874357
50Abnormality of the heme biosynthetic pathway (HP:0010472)2.34822285
51Pancreatic fibrosis (HP:0100732)2.34559229
52Cerebral edema (HP:0002181)2.32259319
53Myelodysplasia (HP:0002863)2.29251047
54Abnormality of the anterior horn cell (HP:0006802)2.28553060
55Degeneration of anterior horn cells (HP:0002398)2.28553060
56Adrenal hypoplasia (HP:0000835)2.28456489
57Septo-optic dysplasia (HP:0100842)2.27797800
58Medulloblastoma (HP:0002885)2.26904819
59Upper limb muscle weakness (HP:0003484)2.26333781
60Absent thumb (HP:0009777)2.23932316
61Triphalangeal thumb (HP:0001199)2.23789103
62Muscle fiber atrophy (HP:0100295)2.23508249
63Increased hepatocellular lipid droplets (HP:0006565)2.23318317
64Sloping forehead (HP:0000340)2.22711458
65Hepatocellular necrosis (HP:0001404)2.20768740
66True hermaphroditism (HP:0010459)2.18551781
67Pancreatic cysts (HP:0001737)2.17352945
68Colon cancer (HP:0003003)2.16514435
69Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16387364
70Hepatic necrosis (HP:0002605)2.14487847
71Reduced antithrombin III activity (HP:0001976)2.14199054
72Ependymoma (HP:0002888)2.13837817
73Abnormality of the carotid arteries (HP:0005344)2.11301874
74Duplication of thumb phalanx (HP:0009942)2.10984812
75Abnormality of the fovea (HP:0000493)2.09251142
76Methylmalonic acidemia (HP:0002912)2.08852344
77Premature ovarian failure (HP:0008209)2.08759168
78Horseshoe kidney (HP:0000085)2.07894378
79Hypergonadotropic hypogonadism (HP:0000815)2.05176972
80Abnormality of the fetal cardiovascular system (HP:0010948)2.04610661
81Abnormal umbilical cord blood vessels (HP:0011403)2.04610661
82Single umbilical artery (HP:0001195)2.04610661
83Neoplasm of the adrenal gland (HP:0100631)2.03322870
84Megaloblastic anemia (HP:0001889)2.02604114
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01768408
86Abnormal protein N-linked glycosylation (HP:0012347)2.01768408
87Abnormal protein glycosylation (HP:0012346)2.01768408
88Abnormal glycosylation (HP:0012345)2.01768408
89Glioma (HP:0009733)2.00921064
90Type I transferrin isoform profile (HP:0003642)2.00125207
91Rhabdomyosarcoma (HP:0002859)1.99753766
92Bifid tongue (HP:0010297)1.95056348
93Absent septum pellucidum (HP:0001331)1.94731425
94Nephrogenic diabetes insipidus (HP:0009806)1.94341548
95Abnormal number of erythroid precursors (HP:0012131)1.93397382
96Medial flaring of the eyebrow (HP:0010747)1.93091016
97Pancytopenia (HP:0001876)1.92846421
98Respiratory difficulties (HP:0002880)1.91988876
99Abnormality of the septum pellucidum (HP:0007375)1.91773494
100Ectopic kidney (HP:0000086)1.91406512
101Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90971776
102Abnormality of cells of the erythroid lineage (HP:0012130)1.90802887
103Abnormality of sulfur amino acid metabolism (HP:0004339)1.90427377
104Abnormal spermatogenesis (HP:0008669)1.89905492
105Impulsivity (HP:0100710)1.89805870
106Congenital primary aphakia (HP:0007707)1.89073383
107Increased nuchal translucency (HP:0010880)1.88488246
108Increased serum lactate (HP:0002151)1.88029609
109Neoplasm of the colon (HP:0100273)1.86877638
110Horizontal nystagmus (HP:0000666)1.86207179
111Short thumb (HP:0009778)1.86135867
112Multiple enchondromatosis (HP:0005701)1.85914981
113Premature graying of hair (HP:0002216)1.85869632
114Pancreatic islet-cell hyperplasia (HP:0004510)1.85151733
115Abnormality of serum amino acid levels (HP:0003112)1.84957189
116Male pseudohermaphroditism (HP:0000037)1.84904398
117Squamous cell carcinoma (HP:0002860)1.84283312
118Gait imbalance (HP:0002141)1.84243840
119Lactic acidosis (HP:0003128)1.84071793
120Asplenia (HP:0001746)1.83936730
121Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83084316
122Abnormality of the clitoris (HP:0000056)1.80829773
123Lipid accumulation in hepatocytes (HP:0006561)1.80779179
124Intestinal atresia (HP:0011100)1.80005475
125Oligohydramnios (HP:0001562)1.79639842
126Abnormal biliary tract physiology (HP:0012439)1.79524362
127Bile duct proliferation (HP:0001408)1.79524362
128Patchy hypopigmentation of hair (HP:0011365)1.79298550
129Aplasia/Hypoplasia of the macula (HP:0008059)1.77988191
130Mitochondrial inheritance (HP:0001427)1.77287255
131Secondary amenorrhea (HP:0000869)1.77012364
132Median cleft lip (HP:0000161)1.76552463
133CNS hypomyelination (HP:0003429)1.75837203
134Breast aplasia (HP:0100783)1.75231255
135Preaxial hand polydactyly (HP:0001177)1.74394057
136Acute necrotizing encephalopathy (HP:0006965)1.74288915
137Abnormality of the axillary hair (HP:0100134)1.74194489
138Abnormality of secondary sexual hair (HP:0009888)1.74194489
139Increased CSF lactate (HP:0002490)1.73876917
140Aplasia/Hypoplasia of the breasts (HP:0010311)1.73745248
141Posterior subcapsular cataract (HP:0007787)1.73410456
142Abnormal gallbladder physiology (HP:0012438)1.72614734
143Cholecystitis (HP:0001082)1.72614734
144Pallor (HP:0000980)1.72567497
145Renal Fanconi syndrome (HP:0001994)1.70662660
146Abnormality of the umbilical cord (HP:0010881)1.70344686
147Rough bone trabeculation (HP:0100670)1.70012248
148Methylmalonic aciduria (HP:0012120)1.69474446
149Abnormality of the astrocytes (HP:0100707)1.69249408
150Astrocytoma (HP:0009592)1.69249408
151Clitoromegaly (HP:0000057)1.69127408
152Sparse eyelashes (HP:0000653)1.68113014
153Aganglionic megacolon (HP:0002251)1.67803879
154Leukodystrophy (HP:0002415)1.67528311
155Abnormalities of placenta or umbilical cord (HP:0001194)1.67270946
156Abnormality of cochlea (HP:0000375)1.66640725
157Choanal atresia (HP:0000453)1.66031241

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.45682876
2BUB12.93856935
3MST42.93288254
4TTK2.86942286
5PLK42.81373506
6MKNK22.72322449
7CDC72.71893071
8SRPK12.69702948
9CASK2.58642970
10VRK22.52699404
11VRK12.46403308
12MKNK12.46302568
13TRIM282.44663809
14EIF2AK12.22375286
15WEE12.18415058
16CDK82.06507770
17LATS12.04725019
18BRAF1.94089963
19ACVR1B1.89324814
20PLK11.80686374
21MUSK1.66425080
22PLK31.65189477
23ZAK1.64826761
24BMPR1B1.64480895
25CHEK21.49365091
26GRK11.49215762
27TSSK61.39713360
28TNIK1.38792543
29EIF2AK21.38365925
30AURKA1.33071213
31ERBB41.32264192
32MAP3K61.31793718
33TLK11.30264129
34CCNB11.29717690
35EIF2AK31.28090143
36STK31.27298774
37TAF11.27095877
38DYRK21.26974219
39ATR1.26854216
40PDK21.26467469
41NEK61.19916578
42AURKB1.19874939
43CDK191.19863831
44BRSK21.19376369
45DYRK31.19001248
46FRK1.13501723
47PASK1.12721720
48ERBB31.11604803
49CDK71.10342322
50MAPK131.08382634
51BMPR21.07800588
52AKT31.06251787
53NME11.04533598
54PBK1.04220357
55CSNK1G31.02523986
56CDK30.98394434
57PNCK0.95917415
58MAP2K70.93656585
59NEK20.92606886
60ADRBK20.88989613
61BCR0.88837250
62YES10.87308135
63MELK0.87017148
64STK100.85859664
65CSNK1A1L0.84804236
66SCYL20.83147953
67IRAK20.82646072
68RPS6KB20.81424351
69IRAK30.80021583
70TXK0.78824457
71CSNK1G10.77556732
72NME20.76732289
73ATM0.76503684
74CHEK10.76170204
75STK390.72225897
76IRAK10.70402611
77BRD40.70340006
78CLK10.67030890
79CSNK2A10.65824553
80TGFBR10.65505841
81IRAK40.65337831
82MAPKAPK50.64720165
83TAOK30.64503531
84BRSK10.60978566
85MOS0.60267088
86FGFR10.58855965
87TESK20.56265613
88CSNK2A20.56081971
89INSRR0.55889474
90PRKCI0.55592995
91CDK10.53692616
92RPS6KA50.53281241
93NUAK10.53237665
94DAPK10.52760371
95OXSR10.51941650
96GRK70.50343840
97CSNK1G20.49279487
98PAK40.47865128
99CDK20.46291849
100MAP3K80.45731251
101MAP4K20.45614323
102PLK20.45045392
103EPHA20.41967128
104TEC0.40657030
105MAPKAPK30.40259782
106MST1R0.40067430
107NEK10.37791425
108WNK30.36741128
109CDK90.36621971
110MAP3K120.36301749
111CDK40.35211193
112CSNK1E0.34974006
113SIK30.33922341
114NLK0.33894127
115MARK30.32368282
116ALK0.31361930
117STK40.30668125
118PAK10.30326644
119PKN10.28134175
120PRKDC0.26561812
121CSNK1D0.26356363
122FER0.25418015
123DYRK1A0.24579176
124STK38L0.24381567
125MET0.23688854
126BCKDK0.23216351
127STK240.20486161
128PRKACB0.17759613

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.20441543
2DNA replication_Homo sapiens_hsa030304.01246849
3RNA polymerase_Homo sapiens_hsa030203.68361684
4Homologous recombination_Homo sapiens_hsa034403.49457564
5Fanconi anemia pathway_Homo sapiens_hsa034603.35644823
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.32387809
7Nucleotide excision repair_Homo sapiens_hsa034203.02882103
8Proteasome_Homo sapiens_hsa030503.02440787
9Basal transcription factors_Homo sapiens_hsa030222.96978510
10Non-homologous end-joining_Homo sapiens_hsa034502.87331065
11Spliceosome_Homo sapiens_hsa030402.68132391
12Ribosome_Homo sapiens_hsa030102.67312807
13Base excision repair_Homo sapiens_hsa034102.65554027
14RNA degradation_Homo sapiens_hsa030182.55852162
15RNA transport_Homo sapiens_hsa030132.53227702
16Pyrimidine metabolism_Homo sapiens_hsa002402.44994661
17* Cell cycle_Homo sapiens_hsa041102.36642614
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05484363
19One carbon pool by folate_Homo sapiens_hsa006702.00202488
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88372758
21Propanoate metabolism_Homo sapiens_hsa006401.86764118
22Protein export_Homo sapiens_hsa030601.82435246
23Vitamin B6 metabolism_Homo sapiens_hsa007501.62383478
24Purine metabolism_Homo sapiens_hsa002301.61068613
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58165027
26mRNA surveillance pathway_Homo sapiens_hsa030151.54127581
27Pyruvate metabolism_Homo sapiens_hsa006201.50076562
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42016070
29p53 signaling pathway_Homo sapiens_hsa041151.35669784
30Oxidative phosphorylation_Homo sapiens_hsa001901.30508169
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23383892
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21092360
33Huntingtons disease_Homo sapiens_hsa050161.17985350
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17487556
35Parkinsons disease_Homo sapiens_hsa050121.11260443
36Ether lipid metabolism_Homo sapiens_hsa005651.09421451
37Linoleic acid metabolism_Homo sapiens_hsa005911.05631096
38Arachidonic acid metabolism_Homo sapiens_hsa005900.97676876
39Carbon metabolism_Homo sapiens_hsa012000.93924659
40Biosynthesis of amino acids_Homo sapiens_hsa012300.93558686
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87868044
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87000504
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86648157
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86082494
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85741725
46Epstein-Barr virus infection_Homo sapiens_hsa051690.80327358
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79472006
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78743589
49Butanoate metabolism_Homo sapiens_hsa006500.78447809
50Autoimmune thyroid disease_Homo sapiens_hsa053200.77860331
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.77458406
52Oocyte meiosis_Homo sapiens_hsa041140.74685019
53Phototransduction_Homo sapiens_hsa047440.74462487
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73639194
55Folate biosynthesis_Homo sapiens_hsa007900.69859115
56N-Glycan biosynthesis_Homo sapiens_hsa005100.69693706
57Systemic lupus erythematosus_Homo sapiens_hsa053220.69668830
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69020178
59Fatty acid metabolism_Homo sapiens_hsa012120.68077002
60Regulation of autophagy_Homo sapiens_hsa041400.66935057
61Sphingolipid metabolism_Homo sapiens_hsa006000.66190197
62Caffeine metabolism_Homo sapiens_hsa002320.65865527
63Peroxisome_Homo sapiens_hsa041460.63793839
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63650110
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61484593
66Alzheimers disease_Homo sapiens_hsa050100.60063170
67Sulfur metabolism_Homo sapiens_hsa009200.59237356
68Fatty acid degradation_Homo sapiens_hsa000710.58559491
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56675444
70Primary immunodeficiency_Homo sapiens_hsa053400.56181269
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55889725
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.52637154
73Other glycan degradation_Homo sapiens_hsa005110.52508431
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51420501
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50735913
76Metabolic pathways_Homo sapiens_hsa011000.50558961
77Herpes simplex infection_Homo sapiens_hsa051680.47982629
78Allograft rejection_Homo sapiens_hsa053300.46963619
79beta-Alanine metabolism_Homo sapiens_hsa004100.45385731
80Nicotine addiction_Homo sapiens_hsa050330.44822608
81Glutathione metabolism_Homo sapiens_hsa004800.41729402
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40195676
83Hematopoietic cell lineage_Homo sapiens_hsa046400.40027885
84Ovarian steroidogenesis_Homo sapiens_hsa049130.39349111
85Lysine degradation_Homo sapiens_hsa003100.39281402
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38358389
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38176581
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37493839
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37158180
90Asthma_Homo sapiens_hsa053100.35911053
91Fatty acid elongation_Homo sapiens_hsa000620.34974877
92Sulfur relay system_Homo sapiens_hsa041220.34692051
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.34100681
94Retinol metabolism_Homo sapiens_hsa008300.33861135
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32074515
96Tryptophan metabolism_Homo sapiens_hsa003800.30872140
97Viral carcinogenesis_Homo sapiens_hsa052030.30759137
98Arginine and proline metabolism_Homo sapiens_hsa003300.30663196
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30657699
100Nitrogen metabolism_Homo sapiens_hsa009100.29769233
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29309658
102Steroid biosynthesis_Homo sapiens_hsa001000.29295481
103Chemical carcinogenesis_Homo sapiens_hsa052040.28115110
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27860834
105TGF-beta signaling pathway_Homo sapiens_hsa043500.27765644
106Alcoholism_Homo sapiens_hsa050340.27576427
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26690862
108Circadian rhythm_Homo sapiens_hsa047100.26512284
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25318537
110Tyrosine metabolism_Homo sapiens_hsa003500.25088651
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23741936
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.22993747
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.21427743
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20994928
115Cardiac muscle contraction_Homo sapiens_hsa042600.20576531
116Serotonergic synapse_Homo sapiens_hsa047260.20354535
117HTLV-I infection_Homo sapiens_hsa051660.19884751
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.19691249
119Arginine biosynthesis_Homo sapiens_hsa002200.19690052
120Graft-versus-host disease_Homo sapiens_hsa053320.19467217
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18189039
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.16743662
123Collecting duct acid secretion_Homo sapiens_hsa049660.16573512
124Vitamin digestion and absorption_Homo sapiens_hsa049770.16542947
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.15720328
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.15281937
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14193351
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13639243
129Hippo signaling pathway_Homo sapiens_hsa043900.13506025
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12568009
131Measles_Homo sapiens_hsa051620.10116724
132Olfactory transduction_Homo sapiens_hsa047400.09462400
133Selenocompound metabolism_Homo sapiens_hsa004500.08704124
134Type I diabetes mellitus_Homo sapiens_hsa049400.08642790
135Taste transduction_Homo sapiens_hsa047420.08052875
136Basal cell carcinoma_Homo sapiens_hsa052170.07761684
137Hedgehog signaling pathway_Homo sapiens_hsa043400.07365443
138Pentose phosphate pathway_Homo sapiens_hsa000300.06725844
139Wnt signaling pathway_Homo sapiens_hsa043100.06711075
140Antigen processing and presentation_Homo sapiens_hsa046120.06069111

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