ORC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1atrial cardiac muscle cell action potential (GO:0086014)5.34820520
2kidney morphogenesis (GO:0060993)5.25906488
3behavioral response to nicotine (GO:0035095)5.23661830
4DNA replication checkpoint (GO:0000076)5.06650909
5DNA strand elongation involved in DNA replication (GO:0006271)5.01364163
6DNA replication initiation (GO:0006270)4.94625136
7telomere maintenance via semi-conservative replication (GO:0032201)4.89117300
8pseudouridine synthesis (GO:0001522)4.88061782
9mitotic metaphase plate congression (GO:0007080)4.78714630
10DNA strand elongation (GO:0022616)4.77023405
11CENP-A containing nucleosome assembly (GO:0034080)4.71722945
12negative regulation of organelle assembly (GO:1902116)4.67373036
13regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.66265331
14chromatin remodeling at centromere (GO:0031055)4.64174058
15telomere maintenance via recombination (GO:0000722)4.52809347
16peristalsis (GO:0030432)4.46740800
17mitotic recombination (GO:0006312)4.28905699
18urinary tract smooth muscle contraction (GO:0014848)4.20103708
19DNA replication-independent nucleosome assembly (GO:0006336)4.19222223
20DNA replication-independent nucleosome organization (GO:0034724)4.19222223
21kinetochore organization (GO:0051383)4.12048514
22metaphase plate congression (GO:0051310)4.09793777
23protein localization to kinetochore (GO:0034501)4.08755010
24negative regulation of telomere maintenance (GO:0032205)4.08510887
25nucleobase biosynthetic process (GO:0046112)4.04970335
26purine nucleobase biosynthetic process (GO:0009113)4.00252097
27attachment of spindle microtubules to kinetochore (GO:0008608)3.97795034
28DNA replication-dependent nucleosome assembly (GO:0006335)3.97699926
29DNA replication-dependent nucleosome organization (GO:0034723)3.97699926
30telomere maintenance via telomere lengthening (GO:0010833)3.95808127
31histone exchange (GO:0043486)3.92929053
32negative regulation of interleukin-1 beta production (GO:0032691)3.92565774
33kinetochore assembly (GO:0051382)3.90751126
34negative regulation of translation, ncRNA-mediated (GO:0040033)3.89433394
35regulation of translation, ncRNA-mediated (GO:0045974)3.89433394
36negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.89433394
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.88407421
38DNA unwinding involved in DNA replication (GO:0006268)3.87688178
39nucleotide-excision repair, DNA gap filling (GO:0006297)3.87516261
40DNA deamination (GO:0045006)3.82847460
41histone-serine phosphorylation (GO:0035404)3.80106202
42positive regulation of CREB transcription factor activity (GO:0032793)3.75623056
43maturation of SSU-rRNA (GO:0030490)3.72481030
44establishment of chromosome localization (GO:0051303)3.72283892
45regulation of mesoderm development (GO:2000380)3.70645625
46epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.70390004
47protein K6-linked ubiquitination (GO:0085020)3.63758587
48regulation of gene silencing by RNA (GO:0060966)3.63585046
49regulation of posttranscriptional gene silencing (GO:0060147)3.63585046
50regulation of gene silencing by miRNA (GO:0060964)3.63585046
51transcription-coupled nucleotide-excision repair (GO:0006283)3.62960342
52fucose catabolic process (GO:0019317)3.60992405
53L-fucose metabolic process (GO:0042354)3.60992405
54L-fucose catabolic process (GO:0042355)3.60992405
55nonmotile primary cilium assembly (GO:0035058)3.59832931
56antigen processing and presentation via MHC class Ib (GO:0002475)3.58631121
57ribosomal small subunit assembly (GO:0000028)3.58092364
58protein localization to chromosome, centromeric region (GO:0071459)3.57250310
59positive regulation of guanylate cyclase activity (GO:0031284)3.56385532
60regulation of double-strand break repair via homologous recombination (GO:0010569)3.54801496
61formation of translation preinitiation complex (GO:0001731)3.54184807
62postsynaptic membrane organization (GO:0001941)3.53760386
63mitotic nuclear envelope disassembly (GO:0007077)3.53321490
64ribosome assembly (GO:0042255)3.50903578
65spliceosomal snRNP assembly (GO:0000387)3.50588348
66maturation of 5.8S rRNA (GO:0000460)3.50420091
67proteasome assembly (GO:0043248)3.49943692
68positive regulation of respiratory burst (GO:0060267)3.49041989
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.48974175
70ribosome biogenesis (GO:0042254)3.46310189
71regulation of nuclear cell cycle DNA replication (GO:0033262)3.45733918
72pericardium development (GO:0060039)3.45634988
73deoxyribonucleotide biosynthetic process (GO:0009263)3.45598699
74regulation of hippo signaling (GO:0035330)3.44251874
75mitotic sister chromatid segregation (GO:0000070)3.43699457
767-methylguanosine mRNA capping (GO:0006370)3.42731755
77negative regulation of interleukin-1 production (GO:0032692)3.42551358
78deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.41057564
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.38700895
807-methylguanosine RNA capping (GO:0009452)3.38200351
81RNA capping (GO:0036260)3.38200351
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37558739
83meiotic chromosome segregation (GO:0045132)3.37371602
84spindle checkpoint (GO:0031577)3.37107517
85rRNA modification (GO:0000154)3.36903590
86tRNA methylation (GO:0030488)3.36374930
87sulfate transport (GO:0008272)3.31531433
88transcription elongation from RNA polymerase III promoter (GO:0006385)3.30911973
89termination of RNA polymerase III transcription (GO:0006386)3.30911973
90ribonucleoprotein complex biogenesis (GO:0022613)3.29840938
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29711961
92mitotic chromosome condensation (GO:0007076)3.29559984
93establishment of integrated proviral latency (GO:0075713)3.29475365
94response to pheromone (GO:0019236)3.29076810
95adult feeding behavior (GO:0008343)3.28561007
96musculoskeletal movement (GO:0050881)3.27529729
97multicellular organismal movement (GO:0050879)3.27529729
98regulation of histone phosphorylation (GO:0033127)3.26392641
99membrane disassembly (GO:0030397)3.24968429
100nuclear envelope disassembly (GO:0051081)3.24968429
101gap junction assembly (GO:0016264)3.23997849
102IMP biosynthetic process (GO:0006188)3.22666455
103nuclear pore organization (GO:0006999)3.22410278
104negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22112390
105negative regulation of sister chromatid segregation (GO:0033046)3.22112390
106negative regulation of mitotic sister chromatid separation (GO:2000816)3.22112390
107negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22112390
108* cell cycle G1/S phase transition (GO:0044843)3.22020547
109* G1/S transition of mitotic cell cycle (GO:0000082)3.22020547
110negative regulation of chromosome segregation (GO:0051985)3.19561519
111ribosomal large subunit biogenesis (GO:0042273)3.19374541
112regulation of spindle organization (GO:0090224)3.19311043
113rRNA processing (GO:0006364)3.18898651
114spliceosomal complex assembly (GO:0000245)3.18605435
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.18563380
116mismatch repair (GO:0006298)3.17365257
117regulation of guanylate cyclase activity (GO:0031282)3.16984770
118protein deneddylation (GO:0000338)3.14660951
119centriole replication (GO:0007099)3.14205291
120cullin deneddylation (GO:0010388)3.13318935
121spindle assembly checkpoint (GO:0071173)3.13164245
122mitotic spindle checkpoint (GO:0071174)3.11633208
123mitotic spindle assembly checkpoint (GO:0007094)3.10683057
124regulation of mitotic metaphase/anaphase transition (GO:0030071)3.10376578
125cornea development in camera-type eye (GO:0061303)3.10024400
126rRNA metabolic process (GO:0016072)3.08951330
127ribosomal small subunit biogenesis (GO:0042274)3.08314827
128regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.07900884
129regulation of chromosome segregation (GO:0051983)3.07265704
130regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.07238200
131negative regulation of ligase activity (GO:0051352)3.07233726
132negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07233726
133exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07119455
134chromatin assembly or disassembly (GO:0006333)3.06750969
135mitochondrial respiratory chain complex I assembly (GO:0032981)3.06643934
136NADH dehydrogenase complex assembly (GO:0010257)3.06643934
137mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.06643934
138maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.06295965
139telomere organization (GO:0032200)3.06124920
140folic acid-containing compound biosynthetic process (GO:0009396)3.05303095
141telomere maintenance (GO:0000723)3.03574866
142viral mRNA export from host cell nucleus (GO:0046784)3.03333350
143regulation of respiratory system process (GO:0044065)3.02169709
144piRNA metabolic process (GO:0034587)3.01784034
145regulation of microtubule-based movement (GO:0060632)3.01743956
146sister chromatid segregation (GO:0000819)3.01530089
147phasic smooth muscle contraction (GO:0014821)3.01247918
148reciprocal meiotic recombination (GO:0007131)3.00752270
149reciprocal DNA recombination (GO:0035825)3.00752270
150L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.00062809
151chromosome segregation (GO:0007059)2.99505889
152somatic hypermutation of immunoglobulin genes (GO:0016446)2.98895395
153positive regulation of sodium ion transmembrane transport (GO:1902307)2.97103461
154rRNA catabolic process (GO:0016075)2.96835256
155regulation of telomere maintenance (GO:0032204)2.96424466
156endosome to melanosome transport (GO:0035646)2.92395846
157endosome to pigment granule transport (GO:0043485)2.92395846
158positive regulation of antigen processing and presentation (GO:0002579)2.88460948
159sulfation (GO:0051923)2.86531719
160nodal signaling pathway (GO:0038092)2.86499126
161protein polyglutamylation (GO:0018095)2.85879419
162cellular ketone body metabolic process (GO:0046950)2.85162708
163positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.82414716
164kynurenine metabolic process (GO:0070189)2.82385610
165cardiovascular system development (GO:0072358)2.77628703
166somatic diversification of immune receptors via somatic mutation (GO:0002566)2.77059018
167response to xenobiotic stimulus (GO:0009410)2.76089480
168lysine metabolic process (GO:0006553)2.75922845
169lysine catabolic process (GO:0006554)2.75922845
170detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74114315
171mitochondrion morphogenesis (GO:0070584)2.71621777
172endoderm formation (GO:0001706)2.67325318
173organ growth (GO:0035265)2.67083220
174primary amino compound metabolic process (GO:1901160)2.66766312
175embryonic foregut morphogenesis (GO:0048617)2.66730647
176epithelial cilium movement (GO:0003351)2.65170876
177ubiquinone biosynthetic process (GO:0006744)2.63835393
178embryonic axis specification (GO:0000578)2.62461904
179indole-containing compound catabolic process (GO:0042436)2.61257493
180indolalkylamine catabolic process (GO:0046218)2.61257493
181tryptophan catabolic process (GO:0006569)2.61257493
182replication fork processing (GO:0031297)2.60936237
183DNA demethylation (GO:0080111)2.59585772
184RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.58657211
185tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.58657211
186dorsal/ventral axis specification (GO:0009950)2.58152598
187tRNA modification (GO:0006400)2.58046527
188positive regulation of synaptic transmission, GABAergic (GO:0032230)2.57321826
189dermatan sulfate biosynthetic process (GO:0030208)2.57236844
190arginine catabolic process (GO:0006527)2.56942212
191negative regulation of DNA-dependent DNA replication (GO:2000104)2.56025004
192cytidine metabolic process (GO:0046087)2.53876290
193cytidine catabolic process (GO:0006216)2.53876290
194cytidine deamination (GO:0009972)2.53876290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.23296003
2ZNF274_21170338_ChIP-Seq_K562_Hela5.16090412
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.30181662
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.09023929
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.99138101
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.97952075
7EZH2_22144423_ChIP-Seq_EOC_Human3.59127164
8GATA1_22025678_ChIP-Seq_K562_Human3.55318189
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.43473564
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.40688795
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.39269855
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23437552
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17345574
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.99073452
15VDR_22108803_ChIP-Seq_LS180_Human2.97017971
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.95917020
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92441360
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91649118
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82327164
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81286651
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69849720
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.62393482
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.51209554
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.49668907
25VDR_23849224_ChIP-Seq_CD4+_Human2.41475188
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31579598
27XRN2_22483619_ChIP-Seq_HELA_Human2.30788352
28AR_21909140_ChIP-Seq_LNCAP_Human2.30527258
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24069692
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16885571
31DCP1A_22483619_ChIP-Seq_HELA_Human2.15426616
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14965844
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13346369
34E2F1_21310950_ChIP-Seq_MCF-7_Human2.13068984
35CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10417331
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.05490165
37ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03768924
38FOXP3_21729870_ChIP-Seq_TREG_Human2.03479628
39EWS_26573619_Chip-Seq_HEK293_Human2.03353410
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02977784
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02714983
42GBX2_23144817_ChIP-Seq_PC3_Human2.00595494
43MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00143954
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99697784
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96091359
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94838363
47GABP_19822575_ChIP-Seq_HepG2_Human1.93962924
48TTF2_22483619_ChIP-Seq_HELA_Human1.93944442
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.92353169
50ELK1_19687146_ChIP-ChIP_HELA_Human1.92014740
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89156065
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88401453
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86840025
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.84413631
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84413631
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.83397283
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83338529
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81801461
59* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80414500
60FUS_26573619_Chip-Seq_HEK293_Human1.78571495
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76341341
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72583002
63ER_23166858_ChIP-Seq_MCF-7_Human1.69762981
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69256168
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.67142275
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67084227
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.66204935
68REST_21632747_ChIP-Seq_MESCs_Mouse1.65713728
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.57297650
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56698583
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54182819
72HOXB7_26014856_ChIP-Seq_BT474_Human1.53780580
73AR_21572438_ChIP-Seq_LNCaP_Human1.53469287
74TP53_22573176_ChIP-Seq_HFKS_Human1.51005985
75* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49596562
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49161411
77P300_19829295_ChIP-Seq_ESCs_Human1.47060178
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46724225
79RNF2_27304074_Chip-Seq_NSC_Mouse1.46533997
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.45135229
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43307453
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41895942
83STAT3_23295773_ChIP-Seq_U87_Human1.41701394
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41057790
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40883004
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40407794
87ERA_21632823_ChIP-Seq_H3396_Human1.39514644
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38467488
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.38285945
90CIITA_25753668_ChIP-Seq_RAJI_Human1.37530776
91RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37408956
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36721897
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33696300
94KDM5A_27292631_Chip-Seq_BREAST_Human1.32547267
95TCF4_23295773_ChIP-Seq_U87_Human1.32199888
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.31691322
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31691322
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31100251
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.30831681
100SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29904288
101AR_25329375_ChIP-Seq_VCAP_Human1.28407393
102TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24677374
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.23273331
104TP53_16413492_ChIP-PET_HCT116_Human1.22378763
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21752014
106IGF1R_20145208_ChIP-Seq_DFB_Human1.19615280
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19167765
108MYC_18940864_ChIP-ChIP_HL60_Human1.17492191
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17274126
110ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16734002
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16637489
112EZH2_27304074_Chip-Seq_ESCs_Mouse1.16172651
113SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12109954
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.11068636
115MYC_19829295_ChIP-Seq_ESCs_Human1.10622987
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09604598
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08732507
118SALL1_21062744_ChIP-ChIP_HESCs_Human1.06644757
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05708847
120NANOG_20526341_ChIP-Seq_ESCs_Human1.05236258
121KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04332415
122REST_18959480_ChIP-ChIP_MESCs_Mouse1.04251227
123FLI1_27457419_Chip-Seq_LIVER_Mouse1.04213735
124OCT1_27270436_Chip-Seq_PROSTATE_Human1.03181717
125SOX2_19829295_ChIP-Seq_ESCs_Human1.02941221
126NANOG_19829295_ChIP-Seq_ESCs_Human1.02941221
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02921929
128POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02609748
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01938213
130TCF4_22108803_ChIP-Seq_LS180_Human1.01729461
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01415269
132NCOR_22424771_ChIP-Seq_293T_Human1.00962898
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00962740
134FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00785680
135KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00419480
136TAF15_26573619_Chip-Seq_HEK293_Human0.99821373
137SMAD4_21799915_ChIP-Seq_A2780_Human0.99367929
138RNF2_27304074_Chip-Seq_ESCs_Mouse0.99333828
139ELK1_22589737_ChIP-Seq_MCF10A_Human0.98941127
140SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98756329
141CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98600277
142TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98254823
143RUNX2_22187159_ChIP-Seq_PCA_Human0.97972812
144P53_21459846_ChIP-Seq_SAOS-2_Human0.97456714
145BCAT_22108803_ChIP-Seq_LS180_Human0.96646554
146TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95468042
147FLI1_21867929_ChIP-Seq_TH2_Mouse0.95062665
148AR_20517297_ChIP-Seq_VCAP_Human0.94192752
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93905250
150EGR1_19374776_ChIP-ChIP_THP-1_Human0.93372930
151BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93073974
152FOXH1_21741376_ChIP-Seq_EPCs_Human0.92715708
153TAF2_19829295_ChIP-Seq_ESCs_Human0.92265497
154NOTCH1_21737748_ChIP-Seq_TLL_Human0.91833179
155TFEB_21752829_ChIP-Seq_HELA_Human0.91647442
156EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91229487
157TDRD3_21172665_ChIP-Seq_MCF-7_Human0.90460201
158KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89489014
159KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89401063
160DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88513898
161STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87949506
162ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87782991
163EZH2_27294783_Chip-Seq_ESCs_Mouse0.87417845
164DROSHA_22980978_ChIP-Seq_HELA_Human0.86981995
165JARID2_20064375_ChIP-Seq_MESCs_Mouse0.84188516
166NANOG_21062744_ChIP-ChIP_HESCs_Human0.82008805
167IRF1_19129219_ChIP-ChIP_H3396_Human0.81897920
168SOX17_20123909_ChIP-Seq_XEN_Mouse0.81456764
169SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80068567
170NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80048965
171GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78529401
172NANOG_16153702_ChIP-ChIP_HESCs_Human0.78155885
173CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77325736
174CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76652440
175TCF3_18692474_ChIP-Seq_MEFs_Mouse0.73052123
176PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72803885
177POU5F1_16153702_ChIP-ChIP_HESCs_Human0.72746183
178NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.72705196
179* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72640302
180DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70593536
181CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.70208245
182SOX2_16153702_ChIP-ChIP_HESCs_Human0.69863060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.97111780
2MP0010094_abnormal_chromosome_stability5.06806093
3MP0003111_abnormal_nucleus_morphology4.68670018
4MP0004957_abnormal_blastocyst_morpholog4.64413151
5MP0008057_abnormal_DNA_replication4.29113828
6MP0003077_abnormal_cell_cycle4.22090377
7MP0003646_muscle_fatigue3.86761629
8MP0008058_abnormal_DNA_repair3.84808793
9MP0002735_abnormal_chemical_nociception3.12192098
10MP0008932_abnormal_embryonic_tissue3.11028900
11MP0008007_abnormal_cellular_replicative3.08394050
12MP0003195_calcinosis2.83934200
13MP0008877_abnormal_DNA_methylation2.81720518
14MP0003123_paternal_imprinting2.72128357
15MP0005167_abnormal_blood-brain_barrier2.59220456
16MP0003718_maternal_effect2.49815234
17MP0004043_abnormal_pH_regulation2.47446530
18MP0008872_abnormal_physiological_respon2.42071729
19MP0003786_premature_aging2.34336808
20MP0001348_abnormal_lacrimal_gland2.25534676
21MP0001730_embryonic_growth_arrest2.15146527
22MP0000350_abnormal_cell_proliferation2.12272052
23MP0009046_muscle_twitch2.09933394
24MP0006292_abnormal_olfactory_placode2.06341539
25MP0005551_abnormal_eye_electrophysiolog1.96392918
26MP0003121_genomic_imprinting1.87940441
27MP0005645_abnormal_hypothalamus_physiol1.68167707
28MP0003315_abnormal_perineum_morphology1.66794610
29MP0001697_abnormal_embryo_size1.64827978
30MP0003137_abnormal_impulse_conducting1.61295268
31MP0002210_abnormal_sex_determination1.61011407
32MP0009745_abnormal_behavioral_response1.60602647
33MP0001485_abnormal_pinna_reflex1.59097870
34MP0001672_abnormal_embryogenesis/_devel1.56780818
35MP0005380_embryogenesis_phenotype1.56780818
36MP0002396_abnormal_hematopoietic_system1.55565376
37MP0004885_abnormal_endolymph1.54369122
38MP0002085_abnormal_embryonic_tissue1.50710886
39MP0000569_abnormal_digit_pigmentation1.49773112
40MP0000427_abnormal_hair_cycle1.49478738
41MP0002160_abnormal_reproductive_system1.47493415
42MP0002080_prenatal_lethality1.42018688
43MP0003890_abnormal_embryonic-extraembry1.41842095
44MP0002638_abnormal_pupillary_reflex1.41802385
45MP0002733_abnormal_thermal_nociception1.40407147
46MP0009840_abnormal_foam_cell1.39900008
47MP0000383_abnormal_hair_follicle1.38890724
48MP0000490_abnormal_crypts_of1.38147773
49MP0002102_abnormal_ear_morphology1.37457704
50MP0000313_abnormal_cell_death1.36901894
51MP0004742_abnormal_vestibular_system1.35283244
52MP0008875_abnormal_xenobiotic_pharmacok1.35165192
53MP0001145_abnormal_male_reproductive1.33799606
54MP0004924_abnormal_behavior1.33408127
55MP0005386_behavior/neurological_phenoty1.33408127
56MP0002837_dystrophic_cardiac_calcinosis1.33311509
57MP0005253_abnormal_eye_physiology1.32967669
58MP0003984_embryonic_growth_retardation1.32186385
59MP0010307_abnormal_tumor_latency1.31198884
60MP0003806_abnormal_nucleotide_metabolis1.28830229
61MP0001929_abnormal_gametogenesis1.28785599
62MP0002088_abnormal_embryonic_growth/wei1.28362735
63MP0002084_abnormal_developmental_patter1.28099384
64MP0001986_abnormal_taste_sensitivity1.27891267
65MP0002234_abnormal_pharynx_morphology1.27123400
66MP0001970_abnormal_pain_threshold1.26461935
67MP0002272_abnormal_nervous_system1.25736876
68MP0003878_abnormal_ear_physiology1.25406993
69MP0005377_hearing/vestibular/ear_phenot1.25406993
70MP0000653_abnormal_sex_gland1.25126953
71MP0002734_abnormal_mechanical_nocicepti1.24195910
72MP0004142_abnormal_muscle_tone1.23211133
73MP0010352_gastrointestinal_tract_polyps1.22848296
74MP0002019_abnormal_tumor_incidence1.18342986
75MP0000566_synostosis1.18313591
76MP0003567_abnormal_fetal_cardiomyocyte1.16435234
77MP0001486_abnormal_startle_reflex1.15821868
78MP0005389_reproductive_system_phenotype1.15149654
79MP0001119_abnormal_female_reproductive1.14411075
80MP0001968_abnormal_touch/_nociception1.13079613
81MP0003937_abnormal_limbs/digits/tail_de1.12461589
82MP0000631_abnormal_neuroendocrine_gland1.11676649
83MP0004133_heterotaxia1.10972483
84MP0002086_abnormal_extraembryonic_tissu1.09706125
85MP0001529_abnormal_vocalization1.09523881
86MP0002557_abnormal_social/conspecific_i1.08232731
87MP0004197_abnormal_fetal_growth/weight/1.06367109
88MP0002067_abnormal_sensory_capabilities1.05813900
89MP0002572_abnormal_emotion/affect_behav1.04994219
90MP0003941_abnormal_skin_development1.03750407
91MP0001293_anophthalmia1.01889534
92MP0003119_abnormal_digestive_system1.01507852
93MP0003283_abnormal_digestive_organ1.01236419
94MP0002064_seizures1.00896665
95MP0001849_ear_inflammation1.00396953
96MP0010030_abnormal_orbit_morphology1.00299016
97MP0002653_abnormal_ependyma_morphology0.99596192
98MP0008775_abnormal_heart_ventricle0.98937360
99MP0005195_abnormal_posterior_eye0.97068470
100MP0004808_abnormal_hematopoietic_stem0.95296493
101MP0000230_abnormal_systemic_arterial0.94275970
102MP0002063_abnormal_learning/memory/cond0.93345607
103MP0002736_abnormal_nociception_after0.93151047
104MP0001501_abnormal_sleep_pattern0.92912186
105MP0003186_abnormal_redox_activity0.91543975
106MP0009333_abnormal_splenocyte_physiolog0.89894953
107MP0009379_abnormal_foot_pigmentation0.89790084
108MP0003136_yellow_coat_color0.87868988
109MP0005391_vision/eye_phenotype0.86702692
110MP0002938_white_spotting0.86372496
111MP0005448_abnormal_energy_balance0.86355528
112MP0009697_abnormal_copulation0.84248462
113MP0005646_abnormal_pituitary_gland0.83265692
114MP0002111_abnormal_tail_morphology0.82972999
115MP0003943_abnormal_hepatobiliary_system0.82736111
116MP0002132_abnormal_respiratory_system0.82266411
117MP0003787_abnormal_imprinting0.80834040
118MP0008961_abnormal_basal_metabolism0.79440096
119MP0000358_abnormal_cell_content/0.78420021
120MP0003635_abnormal_synaptic_transmissio0.78256223
121MP0004130_abnormal_muscle_cell0.78153494
122MP0001286_abnormal_eye_development0.76722897
123MP0005384_cellular_phenotype0.76575444
124MP0001324_abnormal_eye_pigmentation0.75991577
125MP0002254_reproductive_system_inflammat0.75185142
126MP0008260_abnormal_autophagy0.75109503
127MP0003763_abnormal_thymus_physiology0.74568693
128MP0003950_abnormal_plasma_membrane0.74472895
129MP0000778_abnormal_nervous_system0.74004536
130MP0002751_abnormal_autonomic_nervous0.73655227
131MP0009672_abnormal_birth_weight0.73214082
132MP0000703_abnormal_thymus_morphology0.73102209
133MP0003638_abnormal_response/metabolism_0.72933258
134MP0006276_abnormal_autonomic_nervous0.72835745
135MP0008789_abnormal_olfactory_epithelium0.72603268
136MP0003938_abnormal_ear_development0.72440435
137MP0002822_catalepsy0.72267613
138MP0002876_abnormal_thyroid_physiology0.71630531
139MP0001919_abnormal_reproductive_system0.71574774
140MP0003698_abnormal_male_reproductive0.70793863
141MP0005266_abnormal_metabolism0.70710210
142MP0001186_pigmentation_phenotype0.68798009
143MP0002163_abnormal_gland_morphology0.68548969
144MP0001188_hyperpigmentation0.68514786
145MP0005395_other_phenotype0.68407155
146MP0004215_abnormal_myocardial_fiber0.68286279
147MP0002095_abnormal_skin_pigmentation0.67624806
148MP0003699_abnormal_female_reproductive0.67053055
149MP0000049_abnormal_middle_ear0.66716362
150MP0005621_abnormal_cell_physiology0.63161466
151MP0006035_abnormal_mitochondrial_morpho0.63094174
152MP0002161_abnormal_fertility/fecundity0.62349929
153MP0003755_abnormal_palate_morphology0.61247899
154MP0006036_abnormal_mitochondrial_physio0.58975833
155MP0009703_decreased_birth_body0.58559540
156MP0003936_abnormal_reproductive_system0.58365027
157MP0006072_abnormal_retinal_apoptosis0.57859849
158MP0003221_abnormal_cardiomyocyte_apopto0.57049472
159MP0005408_hypopigmentation0.56922680
160MP0003861_abnormal_nervous_system0.56663723
161MP0002075_abnormal_coat/hair_pigmentati0.56617756
162MP0002722_abnormal_immune_system0.55164292
163MP0000678_abnormal_parathyroid_gland0.54898068
164MP0002398_abnormal_bone_marrow0.54735252
165MP0002114_abnormal_axial_skeleton0.54282726
166MP0000432_abnormal_head_morphology0.53098027
167MP0004147_increased_porphyrin_level0.52451907

Predicted human phenotypes

RankGene SetZ-score
1* Birth length less than 3rd percentile (HP:0003561)5.25939544
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.60945250
3Chromsome breakage (HP:0040012)4.59863189
4Molar tooth sign on MRI (HP:0002419)4.54049249
5Abnormality of midbrain morphology (HP:0002418)4.54049249
6Hyperventilation (HP:0002883)4.29359982
7Congenital stationary night blindness (HP:0007642)4.18760931
8Type II lissencephaly (HP:0007260)3.98519046
9Reticulocytopenia (HP:0001896)3.90833634
10* Breast hypoplasia (HP:0003187)3.70383376
11Meckel diverticulum (HP:0002245)3.68464852
12Protruding tongue (HP:0010808)3.64444456
13Nephronophthisis (HP:0000090)3.61054516
14True hermaphroditism (HP:0010459)3.59177938
15Abnormality of chromosome stability (HP:0003220)3.56401845
16Abnormality of the preputium (HP:0100587)3.51276434
17* Patellar aplasia (HP:0006443)3.48085863
18Abnormality of the ileum (HP:0001549)3.46527886
19Inability to walk (HP:0002540)3.34613300
20Diastasis recti (HP:0001540)3.34221409
21Aplasia/Hypoplasia of the uvula (HP:0010293)3.31317031
22Carpal bone hypoplasia (HP:0001498)3.29041138
23* Aplasia/Hypoplasia of the patella (HP:0006498)3.25683376
24Oral leukoplakia (HP:0002745)3.25093864
25Abnormality of the labia minora (HP:0012880)3.18564177
26Lissencephaly (HP:0001339)3.18155027
27Pendular nystagmus (HP:0012043)3.18019839
28Abnormality of cells of the erythroid lineage (HP:0012130)3.11958669
29Abnormality of alanine metabolism (HP:0010916)3.10172823
30Hyperalaninemia (HP:0003348)3.10172823
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.10172823
32Absent radius (HP:0003974)3.05974634
33Abnormality of the renal medulla (HP:0100957)3.04123976
34Abnormal number of erythroid precursors (HP:0012131)3.02607770
35Long foot (HP:0001833)3.01543034
36Colon cancer (HP:0003003)2.99207571
37Rough bone trabeculation (HP:0100670)2.96084303
38Chorioretinal atrophy (HP:0000533)2.94516109
39Abnormality of the anterior horn cell (HP:0006802)2.93395666
40Degeneration of anterior horn cells (HP:0002398)2.93395666
41Small intestinal stenosis (HP:0012848)2.92324977
42Duodenal stenosis (HP:0100867)2.92324977
43Aplasia involving forearm bones (HP:0009822)2.89856881
44Absent forearm bone (HP:0003953)2.89856881
45Aplastic anemia (HP:0001915)2.88636118
46Depressed nasal tip (HP:0000437)2.81613774
47Partial agenesis of the corpus callosum (HP:0001338)2.80703028
48Cerebral hypomyelination (HP:0006808)2.79777737
49Absent thumb (HP:0009777)2.78495646
50Duplicated collecting system (HP:0000081)2.76031525
51Abnormal respiratory epithelium morphology (HP:0012253)2.74604854
52Abnormal respiratory motile cilium morphology (HP:0005938)2.74604854
53Supernumerary spleens (HP:0009799)2.73110488
54Medulloblastoma (HP:0002885)2.72591851
55Aplasia/Hypoplasia involving the musculature (HP:0001460)2.70903001
56Abnormal lung lobation (HP:0002101)2.70329425
57Bone marrow hypocellularity (HP:0005528)2.69151343
58Large for gestational age (HP:0001520)2.68451674
59Myelodysplasia (HP:0002863)2.66466320
60Clumsiness (HP:0002312)2.63734800
61Selective tooth agenesis (HP:0001592)2.63192409
62Abnormality of the renal cortex (HP:0011035)2.58756200
63Impulsivity (HP:0100710)2.57004127
64Ectopic kidney (HP:0000086)2.54321066
6511 pairs of ribs (HP:0000878)2.53288917
66Horseshoe kidney (HP:0000085)2.53038182
67Triphalangeal thumb (HP:0001199)2.52647266
68Premature graying of hair (HP:0002216)2.52147366
69Attenuation of retinal blood vessels (HP:0007843)2.51892741
70Abnormality of the pons (HP:0007361)2.49986302
71Abnormality of the renal collecting system (HP:0004742)2.49720197
72Nephroblastoma (Wilms tumor) (HP:0002667)2.46208807
73Genetic anticipation (HP:0003743)2.45457900
74Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.42645638
75Broad-based gait (HP:0002136)2.42437895
76Congenital, generalized hypertrichosis (HP:0004540)2.42375262
77Sloping forehead (HP:0000340)2.41432525
78Cerebellar dysplasia (HP:0007033)2.39641410
79Cystic liver disease (HP:0006706)2.39428027
80Abnormality of the duodenum (HP:0002246)2.38410822
81Progressive inability to walk (HP:0002505)2.37264782
82Macrocytic anemia (HP:0001972)2.36439040
83Embryonal renal neoplasm (HP:0011794)2.35610172
84Agnosia (HP:0010524)2.32621432
85Tubular atrophy (HP:0000092)2.31895037
86Secondary amenorrhea (HP:0000869)2.29354508
87Medial flaring of the eyebrow (HP:0010747)2.28083894
88Fair hair (HP:0002286)2.27020650
89Neoplasm of the pancreas (HP:0002894)2.26929991
90Sclerocornea (HP:0000647)2.26899080
91Hypoplasia of the pons (HP:0012110)2.25422124
92Concave nail (HP:0001598)2.25180999
93Abnormal trabecular bone morphology (HP:0100671)2.24782235
94Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24778137
95Retinal dysplasia (HP:0007973)2.23130451
96Hypoplasia of the capital femoral epiphysis (HP:0003090)2.21113389
97Myokymia (HP:0002411)2.20230892
98Short thumb (HP:0009778)2.19862087
99Dynein arm defect of respiratory motile cilia (HP:0012255)2.19330149
100Absent/shortened dynein arms (HP:0200106)2.19330149
101Poor head control (HP:0002421)2.18378311
102Hypoplastic labia majora (HP:0000059)2.18289997
103Pallor (HP:0000980)2.18142449
104Anencephaly (HP:0002323)2.15977572
105Furrowed tongue (HP:0000221)2.15731316
106Gait imbalance (HP:0002141)2.14126967
107Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13316276
108Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13128464
109Long nose (HP:0003189)2.12395519
110Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12179615
111Poor speech (HP:0002465)2.11850570
112Abnormal ciliary motility (HP:0012262)2.10961650
113Clubbing of toes (HP:0100760)2.10672606
114Congenital primary aphakia (HP:0007707)2.09813408
115Tracheoesophageal fistula (HP:0002575)2.09718698
116Optic nerve hypoplasia (HP:0000609)2.09341833
117Abnormality of the carotid arteries (HP:0005344)2.09082888
118Pancreatic cysts (HP:0001737)2.07882403
119Cleft eyelid (HP:0000625)2.06890486
120Ependymoma (HP:0002888)2.06363434
121Type I transferrin isoform profile (HP:0003642)2.05432045
122Cellular immunodeficiency (HP:0005374)2.04930082
123Premature ovarian failure (HP:0008209)2.04375466
124Pancreatic fibrosis (HP:0100732)2.02992573
125Chronic hepatic failure (HP:0100626)2.02688780
126Irregular epiphyses (HP:0010582)2.02117086
127Widely spaced teeth (HP:0000687)2.01325893
128Dandy-Walker malformation (HP:0001305)2.01176215
129Facial hemangioma (HP:0000329)2.00069487
130Abnormality of the labia majora (HP:0012881)1.98407755
131Rhabdomyosarcoma (HP:0002859)1.96652349
132Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96246428
133Increased hepatocellular lipid droplets (HP:0006565)1.95334533
134Pancytopenia (HP:0001876)1.95143701
135Abnormal number of incisors (HP:0011064)1.94884174
136Aplasia/Hypoplasia of the tongue (HP:0010295)1.94493041
137Abolished electroretinogram (ERG) (HP:0000550)1.94416483
138Male pseudohermaphroditism (HP:0000037)1.94005506
139Increased corneal curvature (HP:0100692)1.93643404
140Keratoconus (HP:0000563)1.93643404
1413-Methylglutaconic aciduria (HP:0003535)1.92839820
142Global brain atrophy (HP:0002283)1.92819485
143Non-midline cleft lip (HP:0100335)1.92060573
144Severe muscular hypotonia (HP:0006829)1.91070888
145Anterior segment dysgenesis (HP:0007700)1.90328870
146Abnormal spermatogenesis (HP:0008669)1.89766957
147Nephrogenic diabetes insipidus (HP:0009806)1.88789878
148Facial cleft (HP:0002006)1.88217025
149Increased serum lactate (HP:0002151)1.87551985
150Spastic tetraparesis (HP:0001285)1.85635472
151Poor coordination (HP:0002370)1.85175383
152Abdominal situs inversus (HP:0003363)1.82849624
153Abnormality of abdominal situs (HP:0011620)1.82849624
154Large eyes (HP:0001090)1.82612197
155Abnormal rod and cone electroretinograms (HP:0008323)1.81905069
156Stenosis of the external auditory canal (HP:0000402)1.81859545
157Exertional dyspnea (HP:0002875)1.80026741
158* Atresia of the external auditory canal (HP:0000413)1.78619580
159Abnormality of the vitreous humor (HP:0004327)1.78236478
160Abnormality of DNA repair (HP:0003254)1.77868836
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77842349
162Absent epiphyses (HP:0010577)1.77842349
163Progressive cerebellar ataxia (HP:0002073)1.76932722
164Small hand (HP:0200055)1.75394124
165Hypoplasia of the radius (HP:0002984)1.75167857
166Ureteral duplication (HP:0000073)1.74442447
167Aplasia/Hypoplasia of the tibia (HP:0005772)1.74110272
168Bilateral microphthalmos (HP:0007633)1.73468852
169Decreased activity of mitochondrial respiratory chain (HP:0008972)1.73046061
170Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.73046061
171Cafe-au-lait spot (HP:0000957)1.72810416
172Type 2 muscle fiber atrophy (HP:0003554)1.72416044
173Aplasia/Hypoplasia of the earlobes (HP:0009906)1.72293181
174Optic nerve coloboma (HP:0000588)1.72085109
175Abnormality of the heme biosynthetic pathway (HP:0010472)1.72071814
176Prominent supraorbital ridges (HP:0000336)1.71737934
177Squamous cell carcinoma (HP:0002860)1.70731253
178Decreased central vision (HP:0007663)1.69248134
179Neoplasm of the colon (HP:0100273)1.69235567
180Vaginal atresia (HP:0000148)1.68944510
181Microvesicular hepatic steatosis (HP:0001414)1.68629545
182CNS hypomyelination (HP:0003429)1.67935548
183Trismus (HP:0000211)1.67453762

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B6.03606951
2BUB14.67264409
3CDC74.36661747
4WEE14.20862878
5CASK3.72229706
6DAPK23.60502369
7EIF2AK13.53293348
8PLK43.21172393
9SRPK13.06430365
10STK162.65133104
11FRK2.59841940
12TTK2.49924604
13ADRBK22.49570008
14BRSK22.41050947
15VRK12.32886210
16EIF2AK32.30034748
17ACVR1B2.27594585
18WNK42.22681704
19PLK12.19451491
20MKNK12.15751806
21NEK22.07958376
22CAMKK12.06974367
23INSRR2.03513996
24TSSK62.02693125
25PLK31.98937007
26ZAK1.92874174
27NEK11.91045241
28NME21.86870427
29CCNB11.80645848
30PASK1.79929807
31MKNK21.79915082
32AURKB1.70445420
33CAMK1D1.66398038
34CHEK21.63628719
35ATR1.62611714
36TESK21.60596357
37DYRK31.57659092
38BRSK11.57065200
39TLK11.53341722
40GRK11.52632023
41CDK71.48034045
42STK38L1.42440601
43WNK31.40753843
44AURKA1.40354420
45BRAF1.38574932
46CAMKK21.36938934
47NEK91.36314440
48ADRBK11.30862508
49CDK81.28962512
50CAMK1G1.26093595
51RPS6KA41.16514313
52TNIK1.16398486
53CHEK11.13978147
54DYRK21.09527900
55PTK2B1.07754959
56SIK21.06440573
57MAP3K81.02578237
58PBK1.02272374
59EIF2AK20.97937224
60IRAK30.95352219
61STK40.93159500
62RPS6KB20.87400796
63ATM0.86598650
64MAP2K60.86324731
65EPHA20.85120237
66MAP2K10.83503555
67WNK10.82674561
68MAPK130.82222677
69PINK10.76585845
70CDK20.76259392
71PRKCI0.76005200
72CDK40.73978694
73CSNK2A10.72006992
74CAMK10.71981686
75MELK0.69912093
76MAPK150.69399777
77ARAF0.69225476
78MAP3K70.69162131
79MET0.68728821
80AKT30.66729130
81* CDK10.65523496
82NME10.63900739
83CAMK40.63650412
84CSNK2A20.63567241
85PAK40.62704049
86STK100.61066218
87LATS20.60995865
88PIM10.60334924
89RPS6KA60.59577334
90RPS6KA50.59071425
91NTRK20.59032493
92PRKCG0.58773813
93PIM20.56391171
94MAP3K40.56157738
95BRD40.55814353
96CAMK2A0.55593679
97STK240.53623124
98PNCK0.53338932
99PAK10.52829740
100TGFBR10.51655609
101MAP4K20.51558970
102OXSR10.51533464
103TESK10.51253214
104MAP3K60.49525975
105SCYL20.47425755
106TAOK30.47118379
107NTRK30.47053164
108TIE10.46614309
109LIMK10.46525632
110CLK10.46494701
111STK30.44487080
112IRAK40.42255883
113PKN10.41396597
114CDK30.40947979
115MST40.40870125
116CDK120.38803105
117YES10.38700351
118STK390.36195310
119BMX0.35960450
120PAK30.35424693
121ABL20.33858286
122KDR0.32646046
123PLK20.32108601
124PIK3CA0.31708646
125PAK60.31603735
126NEK60.30686082
127RAF10.30046528
128MAPKAPK50.29479930
129ERBB30.29233466
130CSNK1G30.29056663
131MARK10.28649056
132BMPR20.27884549
133CSNK1E0.27496062
134PRKDC0.26771573
135PRKAA20.24477700
136CHUK0.24388383
137PRKAA10.24084996
138CSNK1A10.23471197
139MAP2K70.23150810
140CDK180.22662530
141CDK11A0.22515642
142MOS0.21923082
143PRKCQ0.21577090
144CDK150.21067659
145ALK0.20524156
146PRKCE0.19913946
147LATS10.18559686
148NUAK10.17923596
149PRKCH0.17606511
150MAPK140.17514968
151AKT20.17450248
152STK110.17374749
153TYRO30.16352937
154CDK140.15899223
155PRKCZ0.15822472
156PRKACA0.15755840
157TEC0.14865439
158MUSK0.14811949
159PRKACB0.14166517
160IKBKB0.13521867
161CSNK1D0.13278755

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.14562660
2Mismatch repair_Homo sapiens_hsa034304.44188744
3RNA polymerase_Homo sapiens_hsa030203.79677762
4Proteasome_Homo sapiens_hsa030503.66443940
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.58059892
6Homologous recombination_Homo sapiens_hsa034403.35888467
7Spliceosome_Homo sapiens_hsa030403.24654819
8Ribosome_Homo sapiens_hsa030103.22814780
9Nucleotide excision repair_Homo sapiens_hsa034203.09224462
10RNA transport_Homo sapiens_hsa030133.02287412
11Nitrogen metabolism_Homo sapiens_hsa009103.01019243
12Base excision repair_Homo sapiens_hsa034102.99372059
13* Cell cycle_Homo sapiens_hsa041102.91977802
14Pyrimidine metabolism_Homo sapiens_hsa002402.75710776
15Fanconi anemia pathway_Homo sapiens_hsa034602.68473677
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.56843080
17Phototransduction_Homo sapiens_hsa047442.55709543
18Basal transcription factors_Homo sapiens_hsa030222.49312891
19RNA degradation_Homo sapiens_hsa030182.20276841
20One carbon pool by folate_Homo sapiens_hsa006702.18970744
21Butanoate metabolism_Homo sapiens_hsa006502.16920555
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.13792155
23Non-homologous end-joining_Homo sapiens_hsa034502.12414109
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09678399
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.05501470
26ABC transporters_Homo sapiens_hsa020102.04278048
27Nicotine addiction_Homo sapiens_hsa050331.82370180
28mRNA surveillance pathway_Homo sapiens_hsa030151.67878079
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66509445
30p53 signaling pathway_Homo sapiens_hsa041151.63438980
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62474110
32Purine metabolism_Homo sapiens_hsa002301.60528506
33Protein export_Homo sapiens_hsa030601.58220214
34Tryptophan metabolism_Homo sapiens_hsa003801.54827316
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47462658
36Caffeine metabolism_Homo sapiens_hsa002321.29023446
37Fatty acid biosynthesis_Homo sapiens_hsa000611.28912607
38Oocyte meiosis_Homo sapiens_hsa041141.17278402
39Epstein-Barr virus infection_Homo sapiens_hsa051691.15500190
40Serotonergic synapse_Homo sapiens_hsa047261.14217842
41Systemic lupus erythematosus_Homo sapiens_hsa053221.11731169
42Huntingtons disease_Homo sapiens_hsa050161.11672647
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06602656
44Ovarian steroidogenesis_Homo sapiens_hsa049131.02314516
45Olfactory transduction_Homo sapiens_hsa047400.99608551
46Morphine addiction_Homo sapiens_hsa050320.99178703
47Vitamin B6 metabolism_Homo sapiens_hsa007500.99141264
48Glycerolipid metabolism_Homo sapiens_hsa005610.98676481
49Parkinsons disease_Homo sapiens_hsa050120.96967286
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95945126
51Taste transduction_Homo sapiens_hsa047420.94887239
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94127996
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93365668
54Histidine metabolism_Homo sapiens_hsa003400.92853643
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92826593
56Oxidative phosphorylation_Homo sapiens_hsa001900.90938923
57Chemical carcinogenesis_Homo sapiens_hsa052040.90771081
58GABAergic synapse_Homo sapiens_hsa047270.86384272
59Cardiac muscle contraction_Homo sapiens_hsa042600.85305673
60Insulin secretion_Homo sapiens_hsa049110.84962908
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79532088
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79431602
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78749891
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78289379
65Glutamatergic synapse_Homo sapiens_hsa047240.77383545
66Calcium signaling pathway_Homo sapiens_hsa040200.77268560
67Viral carcinogenesis_Homo sapiens_hsa052030.76802217
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76530280
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71835405
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70887851
71Circadian entrainment_Homo sapiens_hsa047130.70377163
72Folate biosynthesis_Homo sapiens_hsa007900.69808479
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68892387
74Propanoate metabolism_Homo sapiens_hsa006400.68634802
75Fat digestion and absorption_Homo sapiens_hsa049750.68572721
76beta-Alanine metabolism_Homo sapiens_hsa004100.68164280
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.67749410
78Herpes simplex infection_Homo sapiens_hsa051680.67375181
79Peroxisome_Homo sapiens_hsa041460.66426751
80Vitamin digestion and absorption_Homo sapiens_hsa049770.64686965
81Long-term depression_Homo sapiens_hsa047300.61293717
82Arginine and proline metabolism_Homo sapiens_hsa003300.60295897
83Mineral absorption_Homo sapiens_hsa049780.60082183
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60026138
85HTLV-I infection_Homo sapiens_hsa051660.59646968
86Lysine degradation_Homo sapiens_hsa003100.58817955
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.58751334
88Retinol metabolism_Homo sapiens_hsa008300.58436661
89Dorso-ventral axis formation_Homo sapiens_hsa043200.58076539
90Arginine biosynthesis_Homo sapiens_hsa002200.57942979
91Alcoholism_Homo sapiens_hsa050340.57652661
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.57604394
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55837860
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55339943
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54006819
96Glutathione metabolism_Homo sapiens_hsa004800.52954909
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.52131670
98Pentose phosphate pathway_Homo sapiens_hsa000300.52107782
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51641429
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51101508
101Tyrosine metabolism_Homo sapiens_hsa003500.50120915
102Antigen processing and presentation_Homo sapiens_hsa046120.49865708
103TGF-beta signaling pathway_Homo sapiens_hsa043500.49054501
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.47100534
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.46157470
106MicroRNAs in cancer_Homo sapiens_hsa052060.41554342
107Arachidonic acid metabolism_Homo sapiens_hsa005900.40996675
108Thyroid cancer_Homo sapiens_hsa052160.40631178
109Alzheimers disease_Homo sapiens_hsa050100.37617866
110Biosynthesis of amino acids_Homo sapiens_hsa012300.36833121
111Regulation of autophagy_Homo sapiens_hsa041400.36754947
112Hippo signaling pathway_Homo sapiens_hsa043900.32347412
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.32019751
114N-Glycan biosynthesis_Homo sapiens_hsa005100.31545458
115Metabolic pathways_Homo sapiens_hsa011000.30365911
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29952710
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29657675
118Selenocompound metabolism_Homo sapiens_hsa004500.28825335
119Small cell lung cancer_Homo sapiens_hsa052220.26403226
120Linoleic acid metabolism_Homo sapiens_hsa005910.26353649
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24925499
122Basal cell carcinoma_Homo sapiens_hsa052170.23974199
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23326402
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22876932
125Colorectal cancer_Homo sapiens_hsa052100.22707460
126Hedgehog signaling pathway_Homo sapiens_hsa043400.16957700
127Legionellosis_Homo sapiens_hsa051340.16575130
128Hepatitis B_Homo sapiens_hsa051610.16305627
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15959867
130Shigellosis_Homo sapiens_hsa051310.15455248
131Apoptosis_Homo sapiens_hsa042100.15186337
132Fructose and mannose metabolism_Homo sapiens_hsa000510.12581949
133Pathways in cancer_Homo sapiens_hsa052000.12260788
134Sulfur relay system_Homo sapiens_hsa041220.11864696
135Primary immunodeficiency_Homo sapiens_hsa053400.11448574
136Ether lipid metabolism_Homo sapiens_hsa005650.10545663
137Wnt signaling pathway_Homo sapiens_hsa043100.10095187
138Bladder cancer_Homo sapiens_hsa052190.09940489
139Measles_Homo sapiens_hsa051620.09782933
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08737764
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.08368491
142Asthma_Homo sapiens_hsa053100.05847480
143Renin-angiotensin system_Homo sapiens_hsa046140.04879828
144Melanoma_Homo sapiens_hsa052180.04292372
145Prostate cancer_Homo sapiens_hsa052150.04281894
146Carbon metabolism_Homo sapiens_hsa012000.02912821
147NF-kappa B signaling pathway_Homo sapiens_hsa040640.02636040
148Hematopoietic cell lineage_Homo sapiens_hsa046400.02184198
149Maturity onset diabetes of the young_Homo sapiens_hsa049500.01271442
150Autoimmune thyroid disease_Homo sapiens_hsa053200.00407693
151Sphingolipid metabolism_Homo sapiens_hsa006000.00390573
152NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0137929
153HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0136330
154Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0085808
155Circadian rhythm_Homo sapiens_hsa04710-0.0067170

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