ORM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.10563003
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.53328066
3L-phenylalanine catabolic process (GO:0006559)7.53328066
4epoxygenase P450 pathway (GO:0019373)7.53032721
5omega-hydroxylase P450 pathway (GO:0097267)7.38003123
6L-phenylalanine metabolic process (GO:0006558)7.21471021
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.21471021
8aromatic amino acid family catabolic process (GO:0009074)6.73733339
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.20027667
10tryptophan catabolic process (GO:0006569)6.10110182
11indole-containing compound catabolic process (GO:0042436)6.10110182
12indolalkylamine catabolic process (GO:0046218)6.10110182
13kynurenine metabolic process (GO:0070189)5.88786092
14urea metabolic process (GO:0019627)5.78055337
15urea cycle (GO:0000050)5.78055337
16regulation of plasminogen activation (GO:0010755)5.73061984
17tryptophan metabolic process (GO:0006568)5.71239514
18bile acid biosynthetic process (GO:0006699)5.70649134
19negative regulation of fibrinolysis (GO:0051918)5.67457657
20complement activation, alternative pathway (GO:0006957)5.66995185
21glyoxylate metabolic process (GO:0046487)5.57291949
22regulation of protein activation cascade (GO:2000257)5.55474103
23high-density lipoprotein particle remodeling (GO:0034375)5.54999662
24drug metabolic process (GO:0017144)5.49896953
25regulation of fibrinolysis (GO:0051917)5.44144046
26protein carboxylation (GO:0018214)5.35723311
27peptidyl-glutamic acid carboxylation (GO:0017187)5.35723311
28alpha-linolenic acid metabolic process (GO:0036109)5.31237338
29nitrogen cycle metabolic process (GO:0071941)5.31033040
30oxidative demethylation (GO:0070989)5.30800956
31regulation of humoral immune response (GO:0002920)5.28011149
32cysteine metabolic process (GO:0006534)5.27183373
33sulfur amino acid catabolic process (GO:0000098)5.25827212
34regulation of complement activation (GO:0030449)5.17443016
35regulation of triglyceride catabolic process (GO:0010896)5.04022776
36negative regulation of blood coagulation (GO:0030195)4.99537017
37negative regulation of hemostasis (GO:1900047)4.99537017
38serine family amino acid catabolic process (GO:0009071)4.97332691
39regulation of cholesterol esterification (GO:0010872)4.89177114
40aromatic amino acid family metabolic process (GO:0009072)4.87905543
41bile acid metabolic process (GO:0008206)4.87164028
42reverse cholesterol transport (GO:0043691)4.82361686
43tyrosine metabolic process (GO:0006570)4.78673236
44plasma lipoprotein particle remodeling (GO:0034369)4.75826234
45protein-lipid complex remodeling (GO:0034368)4.75826234
46macromolecular complex remodeling (GO:0034367)4.75826234
47phospholipid efflux (GO:0033700)4.74947339
48phenylpropanoid metabolic process (GO:0009698)4.73351899
49positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.71546802
50homocysteine metabolic process (GO:0050667)4.71195929
51fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.68966746
52acylglycerol homeostasis (GO:0055090)4.68593187
53triglyceride homeostasis (GO:0070328)4.68593187
54negative regulation of coagulation (GO:0050819)4.54288887
55ethanol metabolic process (GO:0006067)4.54005842
56alpha-amino acid catabolic process (GO:1901606)4.53355246
57negative regulation of wound healing (GO:0061045)4.52890636
58positive regulation of blood coagulation (GO:0030194)4.49285032
59positive regulation of hemostasis (GO:1900048)4.49285032
60plasma lipoprotein particle clearance (GO:0034381)4.45948460
61negative regulation of sterol transport (GO:0032372)4.44160771
62negative regulation of cholesterol transport (GO:0032375)4.44160771
63lysine catabolic process (GO:0006554)4.40395660
64lysine metabolic process (GO:0006553)4.40395660
65amino-acid betaine metabolic process (GO:0006577)4.37451029
66coenzyme catabolic process (GO:0009109)4.31013129
67regulation of apoptotic cell clearance (GO:2000425)4.30696230
68killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.29129388
69disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.29129388
70indolalkylamine metabolic process (GO:0006586)4.29125873
71bile acid and bile salt transport (GO:0015721)4.24941026
72amine catabolic process (GO:0009310)4.21732771
73cellular biogenic amine catabolic process (GO:0042402)4.21732771
74S-adenosylmethionine metabolic process (GO:0046500)4.20829773
75glycine metabolic process (GO:0006544)4.19201732
76imidazole-containing compound metabolic process (GO:0052803)4.19136657
77cholesterol efflux (GO:0033344)4.15536000
78cellular amino acid catabolic process (GO:0009063)4.15296301
79fibrinolysis (GO:0042730)4.14729571
80glutamate metabolic process (GO:0006536)4.14433350
81positive regulation of coagulation (GO:0050820)4.12819463
82benzene-containing compound metabolic process (GO:0042537)4.06733021
83arginine metabolic process (GO:0006525)4.06138878
84negative regulation of complement activation (GO:0045916)4.04824827
85cellular glucuronidation (GO:0052695)4.02965522
86serine family amino acid metabolic process (GO:0009069)4.02345501
87cellular ketone body metabolic process (GO:0046950)3.99677752
88cellular modified amino acid catabolic process (GO:0042219)3.99464109
89negative regulation of lipase activity (GO:0060192)3.97428032
90plasma lipoprotein particle assembly (GO:0034377)3.96373329
91* acute-phase response (GO:0006953)3.94861308
92ethanol oxidation (GO:0006069)3.94787164
93intestinal cholesterol absorption (GO:0030299)3.91190715
94alkaloid metabolic process (GO:0009820)3.90696120
95hormone catabolic process (GO:0042447)3.90616759
96heme transport (GO:0015886)3.90613852
97complement activation, classical pathway (GO:0006958)3.89958464
98aldehyde catabolic process (GO:0046185)3.88849258
99* acute inflammatory response (GO:0002526)3.88394228
100dicarboxylic acid biosynthetic process (GO:0043650)3.88095981
101complement activation (GO:0006956)3.86870383
102positive regulation of lipoprotein lipase activity (GO:0051006)3.85974317
103positive regulation of triglyceride lipase activity (GO:0061365)3.85974317
104blood coagulation, intrinsic pathway (GO:0007597)3.85120382
105protein activation cascade (GO:0072376)3.83432307
106cytolysis (GO:0019835)3.77414136
107cofactor catabolic process (GO:0051187)3.76561768
108low-density lipoprotein particle remodeling (GO:0034374)3.76406960
109serine family amino acid biosynthetic process (GO:0009070)3.76286975
110positive regulation of lipid catabolic process (GO:0050996)3.75913004
111positive regulation of fatty acid biosynthetic process (GO:0045723)3.74177348
112acetyl-CoA metabolic process (GO:0006084)3.72968023
113drug catabolic process (GO:0042737)3.72610160
114opsonization (GO:0008228)3.71197792
115very-low-density lipoprotein particle assembly (GO:0034379)3.70892347
116regulation of acute inflammatory response (GO:0002673)3.70094517
117cholesterol homeostasis (GO:0042632)3.66528407
118phospholipid homeostasis (GO:0055091)3.65639392
119flavonoid metabolic process (GO:0009812)3.64546270
120regulation of cholesterol homeostasis (GO:2000188)3.64224752
121carboxylic acid catabolic process (GO:0046395)3.61933217
122organic acid catabolic process (GO:0016054)3.61933217
123regulation of lipoprotein particle clearance (GO:0010984)3.61081964
124sterol homeostasis (GO:0055092)3.60867939
125plasma lipoprotein particle organization (GO:0071827)3.59663295
126negative regulation of protein activation cascade (GO:2000258)3.59283545
127glucuronate metabolic process (GO:0019585)3.57091079
128uronic acid metabolic process (GO:0006063)3.57091079
129protein-lipid complex assembly (GO:0065005)3.55293831
130regulation of bile acid biosynthetic process (GO:0070857)3.50833413
131response to mercury ion (GO:0046689)3.48160489

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.13015171
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.98365490
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.81165288
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.29863002
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.42346409
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.29272163
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.12901863
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.02504505
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.89267858
10* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14693632
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01246505
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7913007
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.91259711
14CLOCK_20551151_ChIP-Seq_293T_Human1.73771231
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57461003
16FOXA2_19822575_ChIP-Seq_HepG2_Human1.54620142
17HTT_18923047_ChIP-ChIP_STHdh_Human1.48117091
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40596010
19GATA1_22025678_ChIP-Seq_K562_Human1.37592373
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37123495
21* HNF4A_19822575_ChIP-Seq_HepG2_Human1.33715311
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29260865
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24569770
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20388623
25RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16454685
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13428339
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07988955
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01841177
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00187584
30SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95738130
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94172785
32IRF8_22096565_ChIP-ChIP_GC-B_Human0.92561065
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92325358
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88143329
35ESR2_21235772_ChIP-Seq_MCF-7_Human0.86064408
36GATA4_25053715_ChIP-Seq_YYC3_Human0.85603030
37ZNF263_19887448_ChIP-Seq_K562_Human0.83637425
38AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83101682
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82040652
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81914885
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80603400
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79232666
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79061514
44SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78049620
45* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.71702794
46TRIM28_21343339_ChIP-Seq_HEK293_Human0.71120112
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70314114
48NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70314114
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.69739941
50KAP1_22055183_ChIP-Seq_ESCs_Mouse0.69297762
51RARA_24833708_ChIP-Seq_LIVER_Mouse0.69197481
52NFE2_27457419_Chip-Seq_LIVER_Mouse0.69147778
53AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68876257
54ESR1_21235772_ChIP-Seq_MCF-7_Human0.68651011
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.68508106
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.67486019
57SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67060807
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66363892
59* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66243909
60BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65325199
61SOX2_21211035_ChIP-Seq_LN229_Human0.65088921
62CEBPB_22108803_ChIP-Seq_LS180_Human0.63842580
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.63703928
64RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60245601
65RAC3_21632823_ChIP-Seq_H3396_Human0.59164044
66CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.58908851
67LXR_22292898_ChIP-Seq_THP-1_Human0.58149645
68* RARB_24833708_ChIP-Seq_LIVER_Mouse0.57607862
69HNFA_21074721_ChIP-Seq_CACO-2_Human0.57336032
70FOXO3_23340844_ChIP-Seq_DLD1_Human0.57332531
71SPI1_20517297_ChIP-Seq_HL60_Human0.56512000
72FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56141337
73SMC4_20622854_ChIP-Seq_HELA_Human0.55525317
74TCF4_18268006_ChIP-ChIP_LS174T_Human0.55147051
75FOXA1_25552417_ChIP-Seq_VCAP_Human0.54637781
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.54239837
77AR_20517297_ChIP-Seq_VCAP_Human0.53834159
78STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53679547
79DNAJC2_21179169_ChIP-ChIP_NT2_Human0.53511287
80EGR1_19032775_ChIP-ChIP_M12_Human0.52463999
81POU5F1_16518401_ChIP-PET_MESCs_Mouse0.51738861
82EZH2_27294783_Chip-Seq_NPCs_Mouse0.51547737
83PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.51140457
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.50974966
85GATA1_19941827_ChIP-Seq_MEL_Mouse0.50770911
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.50395845
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.50017865
88FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49927178
89P53_21459846_ChIP-Seq_SAOS-2_Human0.49628051
90CBP_21632823_ChIP-Seq_H3396_Human0.49566995
91CDX2_20551321_ChIP-Seq_CACO-2_Human0.49530439
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.49413070
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.49317177
94FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.49185537
95* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.48977541
96PPAR_26484153_Chip-Seq_NCI-H1993_Human0.48752505
97MYC_19915707_ChIP-ChIP_AK7_Human0.48710138
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.48159572
99IRF1_19129219_ChIP-ChIP_H3396_Human0.47480281
100PHF8_20622853_ChIP-Seq_HELA_Human0.47419659
101SOX2_20726797_ChIP-Seq_SW620_Human0.47264527
102BCAT_22108803_ChIP-Seq_LS180_Human0.47055657
103SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.45943421
104PIAS1_25552417_ChIP-Seq_VCAP_Human0.45374869
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.45128002
106GATA6_21074721_ChIP-Seq_CACO-2_Human0.45028526
107SMAD1_18555785_Chip-Seq_ESCs_Mouse0.44470064
108E2F1_20622854_ChIP-Seq_HELA_Human0.44258575
109ESET_19884257_ChIP-Seq_ESCs_Mouse0.44116819
110ESR1_20079471_ChIP-ChIP_T-47D_Human0.43787967
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43703807
112SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43641420
113GATA6_25053715_ChIP-Seq_YYC3_Human0.43532936
114TAF2_19829295_ChIP-Seq_ESCs_Human0.42861541
115STAT1_17558387_ChIP-Seq_HELA_Human0.42827032
116GATA3_24758297_ChIP-Seq_MCF-7_Human0.41849201
117TP63_17297297_ChIP-ChIP_HaCaT_Human0.40296836
118GATA2_19941826_ChIP-Seq_K562_Human0.39805693
119ERG_21242973_ChIP-ChIP_JURKAT_Human0.39367059
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.38078166
121GATA1_19941826_ChIP-Seq_K562_Human0.37808488
122CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36807313
123MYC_27129775_Chip-Seq_CORNEA_Mouse0.36798571
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.36604503
125STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36345046
126ERG_20517297_ChIP-Seq_VCAP_Human0.35405468
127FOXH1_21741376_ChIP-Seq_EPCs_Human0.35334659
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.35279762
129CSB_26484114_Chip-Seq_FIBROBLAST_Human0.35147932
130P63_26484246_Chip-Seq_KERATINOCYTES_Human0.34983678
131P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.34777211
132GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.34191695
133SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.33805796

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.05836707
2MP0005360_urolithiasis7.34262621
3MP0005085_abnormal_gallbladder_physiolo6.27143631
4MP0005365_abnormal_bile_salt6.02596885
5MP0008875_abnormal_xenobiotic_pharmacok4.97236058
6MP0003806_abnormal_nucleotide_metabolis3.98981187
7MP0003252_abnormal_bile_duct3.71473591
8MP0010329_abnormal_lipoprotein_level3.62454851
9MP0009840_abnormal_foam_cell3.34110623
10MP0005083_abnormal_biliary_tract2.94054766
11MP0003191_abnormal_cellular_cholesterol2.90684514
12MP0003195_calcinosis2.75264478
13MP0005332_abnormal_amino_acid2.70618504
14MP0001666_abnormal_nutrient_absorption2.52987088
15MP0000609_abnormal_liver_physiology2.19017303
16MP0004019_abnormal_vitamin_homeostasis2.16066074
17MP0002118_abnormal_lipid_homeostasis2.14949411
18MP0002138_abnormal_hepatobiliary_system1.91493607
19MP0005319_abnormal_enzyme/_coenzyme1.79894693
20MP0003868_abnormal_feces_composition1.75942159
21MP0003011_delayed_dark_adaptation1.72189255
22MP0001764_abnormal_homeostasis1.62344032
23MP0005451_abnormal_body_composition1.58165934
24MP0005584_abnormal_enzyme/coenzyme_acti1.56270061
25MP0009697_abnormal_copulation1.43303779
26MP0003186_abnormal_redox_activity1.30429389
27MP0003705_abnormal_hypodermis_morpholog1.29017061
28MP0002254_reproductive_system_inflammat1.24598327
29MP0009643_abnormal_urine_homeostasis1.23348198
30MP0002132_abnormal_respiratory_system1.19709009
31MP0005670_abnormal_white_adipose1.18694891
32MP0003656_abnormal_erythrocyte_physiolo1.16817309
33MP0000598_abnormal_liver_morphology1.15774322
34MP0000604_amyloidosis1.14404351
35MP0009764_decreased_sensitivity_to1.12112709
36MP0005647_abnormal_sex_gland1.12084058
37MP0009763_increased_sensitivity_to1.06970137
38MP0001915_intracranial_hemorrhage1.00202929
39MP0005636_abnormal_mineral_homeostasis0.93589903
40MP0002796_impaired_skin_barrier0.92492842
41MP0008469_abnormal_protein_level0.91949976
42MP0002971_abnormal_brown_adipose0.87532646
43MP0009642_abnormal_blood_homeostasis0.86954399
44MP0010368_abnormal_lymphatic_system0.86074685
45MP0004130_abnormal_muscle_cell0.82016617
46MP0002876_abnormal_thyroid_physiology0.81453770
47MP0009765_abnormal_xenobiotic_induced0.80786115
48MP0005408_hypopigmentation0.78632797
49MP0006036_abnormal_mitochondrial_physio0.77162733
50MP0002078_abnormal_glucose_homeostasis0.76786368
51MP0005376_homeostasis/metabolism_phenot0.76566176
52MP0005334_abnormal_fat_pad0.76555179
53MP0003690_abnormal_glial_cell0.72912162
54MP0003879_abnormal_hair_cell0.71464666
55MP0001661_extended_life_span0.71376365
56MP0002282_abnormal_trachea_morphology0.71162256
57MP0005220_abnormal_exocrine_pancreas0.71118896
58MP0005535_abnormal_body_temperature0.69694718
59MP0005058_abnormal_lysosome_morphology0.68966466
60MP0005187_abnormal_penis_morphology0.66419554
61MP0000566_synostosis0.66205643
62MP0009785_altered_susceptibility_to0.65975520
63MP0009053_abnormal_anal_canal0.65251039
64MP0005666_abnormal_adipose_tissue0.65135266
65MP0005084_abnormal_gallbladder_morpholo0.65083614
66MP0003329_amyloid_beta_deposits0.62280203
67MP0004381_abnormal_hair_follicle0.60225144
68MP0005023_abnormal_wound_healing0.60167558
69MP0010234_abnormal_vibrissa_follicle0.59595757
70MP0005266_abnormal_metabolism0.58029232
71MP0001756_abnormal_urination0.57634950
72MP0000639_abnormal_adrenal_gland0.57521138
73MP0005464_abnormal_platelet_physiology0.57205262
74MP0005448_abnormal_energy_balance0.57196595
75MP0002249_abnormal_larynx_morphology0.56973565
76MP0003436_decreased_susceptibility_to0.55175755
77MP0003724_increased_susceptibility_to0.53395843
78MP0001881_abnormal_mammary_gland0.53179484
79MP0000579_abnormal_nail_morphology0.50907024
80MP0002060_abnormal_skin_morphology0.50357922
81MP0005395_other_phenotype0.49758107
82MP0006035_abnormal_mitochondrial_morpho0.49547077
83MP0003638_abnormal_response/metabolism_0.48034569
84MP0008873_increased_physiological_sensi0.47581725
85MP0004782_abnormal_surfactant_physiolog0.46777233
86MP0004883_abnormal_blood_vessel0.46695154
87MP0002136_abnormal_kidney_physiology0.46453153
88MP0003453_abnormal_keratinocyte_physiol0.45186822
89MP0009384_cardiac_valve_regurgitation0.44593718
90MP0002837_dystrophic_cardiac_calcinosis0.43957528
91MP0008874_decreased_physiological_sensi0.42714167
92MP0009115_abnormal_fat_cell0.42687048
93MP0003718_maternal_effect0.42651807
94MP0003075_altered_response_to0.41992255
95MP0005248_abnormal_Harderian_gland0.40705838
96MP0005166_decreased_susceptibility_to0.39719542
97MP0002822_catalepsy0.39699888
98MP0001243_abnormal_dermal_layer0.39355195
99MP0003953_abnormal_hormone_level0.38954948
100MP0002970_abnormal_white_adipose0.38832601
101MP0000427_abnormal_hair_cycle0.38669166
102MP0002089_abnormal_postnatal_growth/wei0.38471874
103MP0002928_abnormal_bile_duct0.35536349
104MP0005501_abnormal_skin_physiology0.35401437
105MP0004185_abnormal_adipocyte_glucose0.34994481
106MP0008872_abnormal_physiological_respon0.34803382
107MP0009672_abnormal_birth_weight0.34232832
108MP0000249_abnormal_blood_vessel0.33263663
109MP0004947_skin_inflammation0.31905779
110MP0001845_abnormal_inflammatory_respons0.31791258
111MP0005164_abnormal_response_to0.31693436
112MP0001851_eye_inflammation0.31352751
113MP0002168_other_aberrant_phenotype0.31346986
114MP0001853_heart_inflammation0.30403387
115MP0000467_abnormal_esophagus_morphology0.29566280
116MP0003172_abnormal_lysosome_physiology0.28764258
117MP0004272_abnormal_basement_membrane0.27673716
118MP0000920_abnormal_myelination0.26931790
119MP0002128_abnormal_blood_circulation0.22528472
120MP0003632_abnormal_nervous_system0.21874663
121MP0002419_abnormal_innate_immunity0.21848769
122MP0001545_abnormal_hematopoietic_system0.21206633
123MP0005397_hematopoietic_system_phenotyp0.21206633
124MP0000858_altered_metastatic_potential0.21066805
125MP0005167_abnormal_blood-brain_barrier0.19481359
126MP0005025_abnormal_response_to0.19186177

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.33862921
2Deep venous thrombosis (HP:0002625)7.30348443
3Intrahepatic cholestasis (HP:0001406)7.04185922
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.75376488
5Prolonged partial thromboplastin time (HP:0003645)6.52733151
6Hypobetalipoproteinemia (HP:0003563)6.31074289
7Xanthomatosis (HP:0000991)6.23857073
8Complement deficiency (HP:0004431)5.85397605
9Hyperlipoproteinemia (HP:0010980)5.75489295
10Hypolipoproteinemia (HP:0010981)4.79035150
11Joint hemorrhage (HP:0005261)4.76172128
12Abnormality of the common coagulation pathway (HP:0010990)4.69033701
13Epidermoid cyst (HP:0200040)4.60700989
14Hyperammonemia (HP:0001987)4.53412671
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.43117627
16Abnormality of complement system (HP:0005339)4.31635228
17Abnormality of methionine metabolism (HP:0010901)4.28881682
18Hypoalphalipoproteinemia (HP:0003233)4.25405284
19Hyperglycinemia (HP:0002154)4.22772939
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.21570522
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.19956268
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.13461238
23Ketosis (HP:0001946)4.10907221
24Fat malabsorption (HP:0002630)4.00182373
25Hyperglycinuria (HP:0003108)3.79584848
26Abnormality of pyrimidine metabolism (HP:0004353)3.78126217
27Abnormality of the intrinsic pathway (HP:0010989)3.76569135
28Abnormality of serine family amino acid metabolism (HP:0010894)3.76314613
29Abnormality of glycine metabolism (HP:0010895)3.76314613
30Hypoglycemic coma (HP:0001325)3.72074359
31Hypercholesterolemia (HP:0003124)3.55830637
32Spontaneous abortion (HP:0005268)3.51145800
33Conjugated hyperbilirubinemia (HP:0002908)3.50046149
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27380940
35Abnormality of fatty-acid metabolism (HP:0004359)3.24385113
36Hyperbilirubinemia (HP:0002904)3.14057259
37Steatorrhea (HP:0002570)3.06881386
38Myocardial infarction (HP:0001658)3.03275179
39Abnormality of nucleobase metabolism (HP:0010932)3.02929684
40Abnormality of serum amino acid levels (HP:0003112)2.99658033
41Systemic lupus erythematosus (HP:0002725)2.98062144
42Purpura (HP:0000979)2.92775164
43Hepatocellular carcinoma (HP:0001402)2.86775477
44Ketoacidosis (HP:0001993)2.86582177
45Skin nodule (HP:0200036)2.81566431
46Delayed CNS myelination (HP:0002188)2.81152194
47Hypochromic microcytic anemia (HP:0004840)2.73534158
48Amyloidosis (HP:0011034)2.66672735
49Abnormality of purine metabolism (HP:0004352)2.65331418
50Metabolic acidosis (HP:0001942)2.64214550
51Glomerulonephritis (HP:0000099)2.61778910
52Abnormal gallbladder physiology (HP:0012438)2.60825553
53Cholecystitis (HP:0001082)2.60825553
54Lethargy (HP:0001254)2.57889386
55Recurrent gram-negative bacterial infections (HP:0005420)2.57361539
56Osteomalacia (HP:0002749)2.56704581
57Vascular calcification (HP:0004934)2.54011164
58Gingival bleeding (HP:0000225)2.49200838
59Dicarboxylic aciduria (HP:0003215)2.47152870
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47152870
61Pulmonary embolism (HP:0002204)2.46439790
62Abnormal gallbladder morphology (HP:0012437)2.45686296
63Cerebral edema (HP:0002181)2.40705984
64Cholelithiasis (HP:0001081)2.39522814
65Spastic diplegia (HP:0001264)2.39044570
66Acanthocytosis (HP:0001927)2.38926972
67Mitral stenosis (HP:0001718)2.38280386
68Gout (HP:0001997)2.36028051
69Neonatal onset (HP:0003623)2.34341618
70Hypoglycemic seizures (HP:0002173)2.33084099
71Irritability (HP:0000737)2.32542252
72Cardiovascular calcification (HP:0011915)2.25931969
73Esophageal varix (HP:0002040)2.23481749
74Thrombophlebitis (HP:0004418)2.20152507
75Reduced antithrombin III activity (HP:0001976)2.15779561
76Malnutrition (HP:0004395)2.13392292
77Pancreatitis (HP:0001733)2.13131619
78Menorrhagia (HP:0000132)2.12175429
79Brushfield spots (HP:0001088)2.12141155
80Late onset (HP:0003584)2.11658934
81Joint swelling (HP:0001386)2.07263393
82Sensorimotor neuropathy (HP:0007141)2.05778921
83Vomiting (HP:0002013)2.04539579
84Gangrene (HP:0100758)2.02783889
85Abnormality of iron homeostasis (HP:0011031)2.02608204
86Enlarged kidneys (HP:0000105)2.00577254
87Abnormality of the gallbladder (HP:0005264)2.00429148
88Epistaxis (HP:0000421)1.99817558
89Increased serum ferritin (HP:0003281)1.97627597
90Hemorrhage of the eye (HP:0011885)1.96962417
91Opisthotonus (HP:0002179)1.96960121
92Abnormality of transition element cation homeostasis (HP:0011030)1.96444739
93Fair hair (HP:0002286)1.95175105
94Abnormal cartilage morphology (HP:0002763)1.94455995
95Nephritis (HP:0000123)1.92156742
96Arthropathy (HP:0003040)1.91844587
97Rickets (HP:0002748)1.91613551
98Generalized aminoaciduria (HP:0002909)1.90652102
99Abnormality of the Achilles tendon (HP:0005109)1.90392058
100Hydroxyprolinuria (HP:0003080)1.90296683
101Abnormality of proline metabolism (HP:0010907)1.90296683
102Hyperinsulinemic hypoglycemia (HP:0000825)1.87468879
103Hypophosphatemic rickets (HP:0004912)1.85564902
104Bifid scrotum (HP:0000048)1.85149800
105Elevated alkaline phosphatase (HP:0003155)1.84467449
106Hyperphosphaturia (HP:0003109)1.84348545
107Poikilocytosis (HP:0004447)1.80162865
108Alkalosis (HP:0001948)1.78167634
109Hypertriglyceridemia (HP:0002155)1.77989213
110Elevated hepatic transaminases (HP:0002910)1.77172164
111Abnormal enzyme/coenzyme activity (HP:0012379)1.76772534
112Abnormal delivery (HP:0001787)1.75588713
113Hyperglycemia (HP:0003074)1.74471616
114Renal cortical cysts (HP:0000803)1.72280925
115Neonatal hypoglycemia (HP:0001998)1.71006884
116Abnormality of vitamin metabolism (HP:0100508)1.69725945
117Abnormality of alkaline phosphatase activity (HP:0004379)1.69556895
118Abnormality of urine glucose concentration (HP:0011016)1.65817647
119Glycosuria (HP:0003076)1.65817647
120Increased mean platelet volume (HP:0011877)1.63213060
121Increased serum pyruvate (HP:0003542)1.58100192
122Impaired platelet aggregation (HP:0003540)1.52240098
123Abnormal platelet function (HP:0011869)1.52240098
124Abnormal urine phosphate concentration (HP:0012599)1.49826148
125Abnormal platelet volume (HP:0011876)1.49503886
126Cerebral palsy (HP:0100021)1.49133800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.79373577
2ERN15.15659370
3FGFR44.54111126
4SIK14.12787979
5ERBB43.17759041
6INSRR2.71150880
7TAOK32.69015826
8MST1R2.47233677
9MAP2K42.24895112
10PRPF4B2.03098228
11TRIB32.00331380
12LATS11.92887656
13MAPK111.91098644
14TNK21.89892255
15PKN21.84935521
16ICK1.80383466
17TYK21.63403250
18FLT31.61499943
19PIK3CG1.60955103
20PTK61.55839187
21NEK91.53349953
22ABL21.45375872
23NTRK31.37588099
24DAPK21.35899771
25FRK1.35601842
26FGFR21.33774878
27JAK21.27029102
28MAP3K31.24815578
29MAP3K71.21070592
30TBK11.20081312
31PRKAA21.17719804
32CAMK1D1.14674050
33BLK1.13345661
34KDR1.09070548
35MAP3K141.07949263
36ERBB21.07339215
37JAK11.06775999
38NLK1.06649992
39MAP2K31.05919613
40EPHA31.05584905
41EPHB11.04480643
42GRK60.97444736
43STK38L0.97441367
44MET0.96175625
45MAPK40.95124974
46WNK40.92599331
47PINK10.92223494
48PDK20.89746858
49ZAP700.89481258
50MAP3K110.88490396
51RIPK10.87019844
52PRKCZ0.86249082
53CDK60.81342273
54MAPK120.76502802
55CAMK2G0.75417415
56PRKACG0.74378493
57MAPKAPK30.73583219
58CAMKK20.73560851
59MAPK150.73422922
60KSR20.72483341
61FGFR30.71512734
62IRAK30.71499022
63MAP3K100.71416307
64TGFBR20.71182863
65GSK3A0.70860338
66CDK120.70741673
67DYRK1B0.69630797
68MAP2K60.69531038
69IKBKE0.67219886
70PRKG10.65016264
71CSK0.62211622
72AKT30.60071100
73MAP2K10.59196191
74PRKAA10.58238693
75SGK4940.58146040
76SGK2230.58146040
77EIF2AK10.57967783
78TIE10.57827564
79MAP3K60.57761871
80FGFR10.56445952
81PTK20.55836368
82SGK10.53304661
83PRKACA0.52730897
84SCYL20.52281598
85MAP3K50.51180862
86CAMK1G0.50492799
87PKN10.50348091
88CAMKK10.50258560
89PDPK10.50204880
90CSNK1D0.49043684
91CSNK1E0.48908773
92EEF2K0.48543043
93MAPK70.48141130
94SGK30.47570978
95IGF1R0.44966079
96CSF1R0.43676653
97SRC0.43606831
98RPS6KA30.42577714
99GRK10.42200230
100PRKCB0.41816754
101PRKCQ0.41780959
102LATS20.41274843
103PRKACB0.38663786
104EGFR0.37326990
105RET0.37326080
106PDK30.37064704
107PDK40.37064704
108MAP3K20.36263932
109CSNK1G10.35945586
110CSNK2A20.34556323
111CSNK2A10.34467549
112BMX0.33818642
113MTOR0.33722431
114IRAK10.33663087
115FER0.33650818
116MAP3K10.33633894
117TAOK20.33285899
118MAP3K130.33091008
119CDK40.32137586
120BRSK20.31736098
121PRKCG0.31147682
122EPHB20.30757962
123EPHA20.29923580
124CAMK40.28973596
125ABL10.28378102
126SGK20.27363050
127PDK10.27090894
128MAP2K20.26819491
129PDGFRA0.26105193
130PAK30.26102111
131PIK3CA0.25939955
132PBK0.25309891
133EPHA40.25303160

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.48225286
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.53775046
3Nitrogen metabolism_Homo sapiens_hsa009103.52751064
4Arginine biosynthesis_Homo sapiens_hsa002203.19828602
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.19694692
6Complement and coagulation cascades_Homo sapiens_hsa046102.94561793
7Tryptophan metabolism_Homo sapiens_hsa003802.63727787
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55484199
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.54751330
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50787023
11Fatty acid degradation_Homo sapiens_hsa000712.42812528
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32605535
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15618587
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13563895
15Peroxisome_Homo sapiens_hsa041462.07767197
16Butanoate metabolism_Homo sapiens_hsa006501.99485696
17Chemical carcinogenesis_Homo sapiens_hsa052041.96276691
18PPAR signaling pathway_Homo sapiens_hsa033201.95626092
19Caffeine metabolism_Homo sapiens_hsa002321.95022317
20Propanoate metabolism_Homo sapiens_hsa006401.92254785
21Staphylococcus aureus infection_Homo sapiens_hsa051501.92234184
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91678426
23Histidine metabolism_Homo sapiens_hsa003401.88084221
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.85160115
25Fatty acid metabolism_Homo sapiens_hsa012121.79276760
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73308148
27Retinol metabolism_Homo sapiens_hsa008301.69763515
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.69648305
29Phenylalanine metabolism_Homo sapiens_hsa003601.67649850
30beta-Alanine metabolism_Homo sapiens_hsa004101.65567867
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59988399
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59072624
33Selenocompound metabolism_Homo sapiens_hsa004501.54992219
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52612394
35Tyrosine metabolism_Homo sapiens_hsa003501.49194813
36Bile secretion_Homo sapiens_hsa049761.42494101
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38535496
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.35506348
39Pyruvate metabolism_Homo sapiens_hsa006201.34747235
40Fatty acid elongation_Homo sapiens_hsa000621.30304630
41Sulfur metabolism_Homo sapiens_hsa009201.28976984
42Starch and sucrose metabolism_Homo sapiens_hsa005001.25395244
43Biosynthesis of amino acids_Homo sapiens_hsa012301.25036096
44Steroid biosynthesis_Homo sapiens_hsa001001.24917870
45Folate biosynthesis_Homo sapiens_hsa007901.23300062
46Fat digestion and absorption_Homo sapiens_hsa049751.22767795
47ABC transporters_Homo sapiens_hsa020101.18375497
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16557450
49Carbon metabolism_Homo sapiens_hsa012001.14062219
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.06652724
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.96528358
52Sulfur relay system_Homo sapiens_hsa041220.94177481
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92624088
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92346439
55Arginine and proline metabolism_Homo sapiens_hsa003300.88615296
56Vitamin B6 metabolism_Homo sapiens_hsa007500.87598916
57Vitamin digestion and absorption_Homo sapiens_hsa049770.87154743
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82329162
59Fatty acid biosynthesis_Homo sapiens_hsa000610.76222303
60Glutathione metabolism_Homo sapiens_hsa004800.72604702
61Lysine degradation_Homo sapiens_hsa003100.72590347
62Glycerolipid metabolism_Homo sapiens_hsa005610.70725293
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69973456
64One carbon pool by folate_Homo sapiens_hsa006700.66221534
65Pentose phosphate pathway_Homo sapiens_hsa000300.64635264
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49909669
67Metabolic pathways_Homo sapiens_hsa011000.45732871
68Prion diseases_Homo sapiens_hsa050200.42708572
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38685330
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32844360
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.28523928
72Linoleic acid metabolism_Homo sapiens_hsa005910.28467824
73Fructose and mannose metabolism_Homo sapiens_hsa000510.28130649
74Insulin resistance_Homo sapiens_hsa049310.25193504
75Galactose metabolism_Homo sapiens_hsa000520.24253475
76Other glycan degradation_Homo sapiens_hsa005110.21155753
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.20908227
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18862172
79Glucagon signaling pathway_Homo sapiens_hsa049220.10312047
80AMPK signaling pathway_Homo sapiens_hsa041520.06475392
81Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2260555
82Bladder cancer_Homo sapiens_hsa05219-0.2075640
83Renin-angiotensin system_Homo sapiens_hsa04614-0.2065534
84Ether lipid metabolism_Homo sapiens_hsa00565-0.2022370
85Type II diabetes mellitus_Homo sapiens_hsa04930-0.2020136
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2019838
87Circadian rhythm_Homo sapiens_hsa04710-0.2015698
88Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2000292
89Amoebiasis_Homo sapiens_hsa05146-0.1955680
90Pertussis_Homo sapiens_hsa05133-0.1901545
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1817082
92Sphingolipid metabolism_Homo sapiens_hsa00600-0.1774050
93Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1540105
94Regulation of autophagy_Homo sapiens_hsa04140-0.1535493
95Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1522395
96Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1511982
97African trypanosomiasis_Homo sapiens_hsa05143-0.1424513
98N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1364871
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1299899
100Hepatitis C_Homo sapiens_hsa05160-0.1234327
101Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0994712
102Insulin signaling pathway_Homo sapiens_hsa04910-0.0857300
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0819032
104Serotonergic synapse_Homo sapiens_hsa04726-0.0787496
105Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0769140
106Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0377579
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0166329
108Mineral absorption_Homo sapiens_hsa04978-0.0095348

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