ORM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.54365852
2epoxygenase P450 pathway (GO:0019373)7.31787607
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.11817451
4L-phenylalanine catabolic process (GO:0006559)7.11817451
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.94847321
6L-phenylalanine metabolic process (GO:0006558)6.94847321
7omega-hydroxylase P450 pathway (GO:0097267)6.88696940
8aromatic amino acid family catabolic process (GO:0009074)6.49037835
9negative regulation of fibrinolysis (GO:0051918)6.30553626
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.27403794
11heme transport (GO:0015886)6.16027171
12tryptophan catabolic process (GO:0006569)6.03756080
13indole-containing compound catabolic process (GO:0042436)6.03756080
14indolalkylamine catabolic process (GO:0046218)6.03756080
15high-density lipoprotein particle remodeling (GO:0034375)5.99996890
16regulation of cholesterol esterification (GO:0010872)5.98166974
17regulation of protein activation cascade (GO:2000257)5.90889572
18complement activation, alternative pathway (GO:0006957)5.89045499
19ethanol oxidation (GO:0006069)5.88500257
20urea cycle (GO:0000050)5.87615163
21urea metabolic process (GO:0019627)5.87615163
22regulation of fibrinolysis (GO:0051917)5.85265124
23* acute-phase response (GO:0006953)5.73101444
24kynurenine metabolic process (GO:0070189)5.70776004
25tryptophan metabolic process (GO:0006568)5.58717570
26peptidyl-glutamic acid carboxylation (GO:0017187)5.56682137
27protein carboxylation (GO:0018214)5.56682137
28uronic acid metabolic process (GO:0006063)5.53389538
29glucuronate metabolic process (GO:0019585)5.53389538
30drug metabolic process (GO:0017144)5.46400543
31regulation of complement activation (GO:0030449)5.40004023
32nitrogen cycle metabolic process (GO:0071941)5.36710050
33phospholipid efflux (GO:0033700)5.28651432
34glyoxylate metabolic process (GO:0046487)5.25741652
35oxidative demethylation (GO:0070989)5.24002834
36bile acid biosynthetic process (GO:0006699)5.17292238
37regulation of triglyceride catabolic process (GO:0010896)5.16448977
38plasma lipoprotein particle remodeling (GO:0034369)5.13881597
39protein-lipid complex remodeling (GO:0034368)5.13881597
40macromolecular complex remodeling (GO:0034367)5.13881597
41reverse cholesterol transport (GO:0043691)5.01383615
42negative regulation of hemostasis (GO:1900047)5.01195555
43negative regulation of blood coagulation (GO:0030195)5.01195555
44phenylpropanoid metabolic process (GO:0009698)4.96657507
45negative regulation of sterol transport (GO:0032372)4.84385387
46negative regulation of cholesterol transport (GO:0032375)4.84385387
47ethanol metabolic process (GO:0006067)4.78088341
48cysteine metabolic process (GO:0006534)4.72648365
49positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.71773417
50sulfur amino acid catabolic process (GO:0000098)4.71086406
51aromatic amino acid family metabolic process (GO:0009072)4.68587831
52plasma lipoprotein particle clearance (GO:0034381)4.67228566
53serine family amino acid catabolic process (GO:0009071)4.65787482
54opsonization (GO:0008228)4.61569364
55alpha-linolenic acid metabolic process (GO:0036109)4.61175105
56negative regulation of coagulation (GO:0050819)4.56217708
57negative regulation of wound healing (GO:0061045)4.55343472
58tyrosine metabolic process (GO:0006570)4.53009987
59cholesterol efflux (GO:0033344)4.50404164
60fibrinolysis (GO:0042730)4.50287784
61plasma lipoprotein particle assembly (GO:0034377)4.44382167
62positive regulation of hemostasis (GO:1900048)4.41244659
63positive regulation of blood coagulation (GO:0030194)4.41244659
64bile acid metabolic process (GO:0008206)4.39529275
65fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.38086042
66iron coordination entity transport (GO:1901678)4.37209199
67acylglycerol homeostasis (GO:0055090)4.35783588
68triglyceride homeostasis (GO:0070328)4.35783588
69negative regulation of lipase activity (GO:0060192)4.32778743
70benzene-containing compound metabolic process (GO:0042537)4.27721813
71homocysteine metabolic process (GO:0050667)4.23277384
72negative regulation of protein activation cascade (GO:2000258)4.23165599
73alpha-amino acid catabolic process (GO:1901606)4.23159791
74indolalkylamine metabolic process (GO:0006586)4.16736529
75very-low-density lipoprotein particle assembly (GO:0034379)4.16676942
76negative regulation of complement activation (GO:0045916)4.15008650
77arginine metabolic process (GO:0006525)4.12841184
78amine catabolic process (GO:0009310)4.12432137
79cellular biogenic amine catabolic process (GO:0042402)4.12432137
80intestinal cholesterol absorption (GO:0030299)4.12344229
81complement activation, classical pathway (GO:0006958)4.10709507
82positive regulation of coagulation (GO:0050820)4.05726966
83protein activation cascade (GO:0072376)4.05061038
84positive regulation of lipoprotein lipase activity (GO:0051006)4.04509663
85positive regulation of triglyceride lipase activity (GO:0061365)4.04509663
86lysine metabolic process (GO:0006553)4.03444757
87lysine catabolic process (GO:0006554)4.03444757
88complement activation (GO:0006956)4.01692405
89blood coagulation, intrinsic pathway (GO:0007597)4.01573256
90S-adenosylmethionine metabolic process (GO:0046500)4.01348009
91regulation of apoptotic cell clearance (GO:2000425)4.00100331
92protein-lipid complex assembly (GO:0065005)3.97537454
93hormone catabolic process (GO:0042447)3.96470389
94alkaloid metabolic process (GO:0009820)3.96225919
95coenzyme catabolic process (GO:0009109)3.95143756
96* acute inflammatory response (GO:0002526)3.89197204
97amino-acid betaine metabolic process (GO:0006577)3.87496817
98plasma lipoprotein particle organization (GO:0071827)3.86034122
99positive regulation of lipid catabolic process (GO:0050996)3.85446681
100glutamate metabolic process (GO:0006536)3.83319266
101cellular amino acid catabolic process (GO:0009063)3.82751390
102regulation of humoral immune response (GO:0002920)3.81284904
103regulation of plasminogen activation (GO:0010755)3.80582776
104cofactor catabolic process (GO:0051187)3.79018245
105drug catabolic process (GO:0042737)3.77622609
106low-density lipoprotein particle remodeling (GO:0034374)3.77150888
107dicarboxylic acid biosynthetic process (GO:0043650)3.76943860
108killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.76652928
109disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.76652928
110cellular modified amino acid catabolic process (GO:0042219)3.73271159
111bile acid and bile salt transport (GO:0015721)3.72787584
112glycine metabolic process (GO:0006544)3.69501909
113response to phenylpropanoid (GO:0080184)3.69210683
114imidazole-containing compound metabolic process (GO:0052803)3.65751976
115serine family amino acid metabolic process (GO:0009069)3.65588127
116regulation of lipoprotein particle clearance (GO:0010984)3.65507434
117protein-lipid complex subunit organization (GO:0071825)3.62598356
118positive regulation of fatty acid biosynthetic process (GO:0045723)3.62365560
119flavonoid metabolic process (GO:0009812)3.59872976
120aldehyde catabolic process (GO:0046185)3.58504931
121response to nitrosative stress (GO:0051409)3.57436772
122lipoprotein metabolic process (GO:0042157)3.56095743
123serine family amino acid biosynthetic process (GO:0009070)3.55327948
124cholesterol homeostasis (GO:0042632)3.54995240
125cellular glucuronidation (GO:0052695)3.54275712
126negative regulation of fatty acid biosynthetic process (GO:0045717)3.53937303
127positive regulation of humoral immune response (GO:0002922)3.52996097
128regulation of acute inflammatory response (GO:0002673)3.51049069
129sterol homeostasis (GO:0055092)3.50118538
130cytolysis (GO:0019835)3.49594474
131regulation of bile acid biosynthetic process (GO:0070857)3.44549827

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.89344628
2* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.82032508
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.73658052
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.09572000
5* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.64319401
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.27620361
7* PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.05028036
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.51141006
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.10989632
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0057431
11* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97360553
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.96830420
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88161533
14CLOCK_20551151_ChIP-Seq_293T_Human1.77882767
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74651965
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58471336
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.57038883
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56986092
19ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51349658
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.50589510
21* HNF4A_19822575_ChIP-Seq_HepG2_Human1.30555720
22HTT_18923047_ChIP-ChIP_STHdh_Human1.26956312
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22089059
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20878509
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.20562528
26GATA1_22025678_ChIP-Seq_K562_Human1.14978651
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13964889
28RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07274230
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03755803
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02093238
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00551457
32ESR2_21235772_ChIP-Seq_MCF-7_Human0.94461822
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93875013
34SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87906156
35BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86392602
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83556129
37ESR1_21235772_ChIP-Seq_MCF-7_Human0.81539293
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81494592
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81174253
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80259998
41* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79133329
42NFE2_27457419_Chip-Seq_LIVER_Mouse0.77915857
43ZNF263_19887448_ChIP-Seq_K562_Human0.77757036
44SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77003512
45SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76315071
46AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73171873
47GATA4_25053715_ChIP-Seq_YYC3_Human0.71870289
48SOX2_21211035_ChIP-Seq_LN229_Human0.71764661
49TCF4_18268006_ChIP-ChIP_LS174T_Human0.70677152
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.67810553
51RARA_24833708_ChIP-Seq_LIVER_Mouse0.67743703
52BP1_19119308_ChIP-ChIP_Hs578T_Human0.67437897
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.66402459
54NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65735517
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65735517
56CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.64986068
57AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64813456
58HNFA_21074721_ChIP-Seq_CACO-2_Human0.63842652
59FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63046473
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.62432303
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.62088990
62RAC3_21632823_ChIP-Seq_H3396_Human0.60848207
63STAT3_1855785_ChIP-Seq_MESCs_Mouse0.60558172
64LXR_22292898_ChIP-Seq_THP-1_Human0.59731212
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58571162
66TP53_18474530_ChIP-ChIP_U2OS_Human0.58377957
67BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58228303
68EZH2_27294783_Chip-Seq_NPCs_Mouse0.57975141
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.57893446
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57589300
71CEBPB_22108803_ChIP-Seq_LS180_Human0.55792913
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.55790490
73CDX2_20551321_ChIP-Seq_CACO-2_Human0.55785317
74DNAJC2_21179169_ChIP-ChIP_NT2_Human0.55657456
75POU5F1_16518401_ChIP-PET_MESCs_Mouse0.55641553
76SPI1_20517297_ChIP-Seq_HL60_Human0.55166843
77RAD21_21589869_ChIP-Seq_MESCs_Mouse0.55130763
78GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.55011291
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.54672110
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.54239748
81SMC4_20622854_ChIP-Seq_HELA_Human0.53108947
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.52779066
83SMAD1_18555785_Chip-Seq_ESCs_Mouse0.52752341
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.52509188
85SUZ12_27294783_Chip-Seq_NPCs_Mouse0.52468979
86PHF8_20622853_ChIP-Seq_HELA_Human0.52396201
87ELF1_20517297_ChIP-Seq_JURKAT_Human0.52272723
88SOX2_20726797_ChIP-Seq_SW620_Human0.52116669
89RARB_24833708_ChIP-Seq_LIVER_Mouse0.51940910
90RUNX1_27457419_Chip-Seq_LIVER_Mouse0.50849221
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.50796298
92GATA6_21074721_ChIP-Seq_CACO-2_Human0.50507387
93CBX2_22325352_ChIP-Seq_293T-Rex_Human0.50286742
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.49858214
95PCGF2_27294783_Chip-Seq_NPCs_Mouse0.49811676
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.49474785
97ESRRB_18555785_Chip-Seq_ESCs_Mouse0.49346400
98NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.49269357
99AR_20517297_ChIP-Seq_VCAP_Human0.49256944
100FOXA1_25552417_ChIP-Seq_VCAP_Human0.49194321
101* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.48967849
102ETV2_25802403_ChIP-Seq_MESCs_Mouse0.48681887
103FOXO3_23340844_ChIP-Seq_DLD1_Human0.47990170
104CBP_21632823_ChIP-Seq_H3396_Human0.45480607
105EGR1_19032775_ChIP-ChIP_M12_Human0.45362144
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.44800052
107FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.44298858
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43098540
109STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.42935236
110GATA2_19941826_ChIP-Seq_K562_Human0.42685267
111NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.42596942
112* TRIM28_21343339_ChIP-Seq_HEK293_Human0.42008008
113GATA6_25053715_ChIP-Seq_YYC3_Human0.41881747
114PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.41546841
115MYC_19915707_ChIP-ChIP_AK7_Human0.41479546
116SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.40941464
117FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.40349061
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.40224778
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39828886
120SRY_22984422_ChIP-ChIP_TESTIS_Rat0.39687497
121GATA1_19941826_ChIP-Seq_K562_Human0.39175179
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.38851897
123FOXH1_21741376_ChIP-Seq_EPCs_Human0.38455492
124CSB_26484114_Chip-Seq_FIBROBLAST_Human0.37466653
125MYC_27129775_Chip-Seq_CORNEA_Mouse0.37463816
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.37135456
127EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.37084674
128TAF2_19829295_ChIP-Seq_ESCs_Human0.36855118
129NCOR_22424771_ChIP-Seq_293T_Human0.36705943
130SPI1_26923725_Chip-Seq_HPCs_Mouse0.36497032
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.36283181
132CDX2_22108803_ChIP-Seq_LS180_Human0.36140357
133RACK7_27058665_Chip-Seq_MCF-7_Human0.36082739
134* P53_21459846_ChIP-Seq_SAOS-2_Human0.36044518
135OCT4_18692474_ChIP-Seq_MEFs_Mouse0.35646074

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.18544255
2MP0005360_urolithiasis7.35032263
3MP0005085_abnormal_gallbladder_physiolo6.15023547
4MP0005365_abnormal_bile_salt6.09560059
5MP0008875_abnormal_xenobiotic_pharmacok4.70283255
6MP0009840_abnormal_foam_cell3.72903859
7MP0003191_abnormal_cellular_cholesterol3.66122890
8MP0003806_abnormal_nucleotide_metabolis3.65792908
9MP0010329_abnormal_lipoprotein_level3.50992866
10MP0003252_abnormal_bile_duct3.38421129
11MP0005083_abnormal_biliary_tract2.96634801
12MP0005332_abnormal_amino_acid2.78495117
13MP0003195_calcinosis2.70238648
14MP0001666_abnormal_nutrient_absorption2.46706015
15MP0000609_abnormal_liver_physiology2.16907519
16MP0002138_abnormal_hepatobiliary_system2.14694348
17MP0002118_abnormal_lipid_homeostasis2.09973895
18MP0004019_abnormal_vitamin_homeostasis2.08508135
19MP0005319_abnormal_enzyme/_coenzyme1.76911090
20MP0003011_delayed_dark_adaptation1.60816689
21MP0001764_abnormal_homeostasis1.59475099
22MP0005584_abnormal_enzyme/coenzyme_acti1.52156319
23MP0003868_abnormal_feces_composition1.45068195
24MP0000604_amyloidosis1.44515275
25MP0009697_abnormal_copulation1.40387402
26MP0009643_abnormal_urine_homeostasis1.35722613
27MP0009764_decreased_sensitivity_to1.32630471
28MP0009763_increased_sensitivity_to1.23587841
29MP0003705_abnormal_hypodermis_morpholog1.23012870
30MP0005636_abnormal_mineral_homeostasis1.18066004
31MP0002132_abnormal_respiratory_system1.16311908
32MP0000598_abnormal_liver_morphology1.15852407
33MP0003656_abnormal_erythrocyte_physiolo1.14080050
34MP0002254_reproductive_system_inflammat1.13029134
35MP0008469_abnormal_protein_level1.11686484
36MP0003186_abnormal_redox_activity1.11049770
37MP0005670_abnormal_white_adipose1.07300597
38MP0001915_intracranial_hemorrhage1.06441324
39MP0001881_abnormal_mammary_gland1.03328986
40MP0005647_abnormal_sex_gland0.98616981
41MP0003690_abnormal_glial_cell0.97470673
42MP0009642_abnormal_blood_homeostasis0.96106733
43MP0005464_abnormal_platelet_physiology0.88266935
44MP0009765_abnormal_xenobiotic_induced0.87512777
45MP0002971_abnormal_brown_adipose0.84212448
46MP0005451_abnormal_body_composition0.83321376
47MP0010368_abnormal_lymphatic_system0.82394992
48MP0005376_homeostasis/metabolism_phenot0.77966799
49MP0003329_amyloid_beta_deposits0.77599101
50MP0009053_abnormal_anal_canal0.76952932
51MP0003436_decreased_susceptibility_to0.75701083
52MP0005408_hypopigmentation0.74314467
53MP0005084_abnormal_gallbladder_morpholo0.71752124
54MP0005187_abnormal_penis_morphology0.71467345
55MP0002078_abnormal_glucose_homeostasis0.71087263
56MP0003879_abnormal_hair_cell0.70332788
57MP0005220_abnormal_exocrine_pancreas0.69642311
58MP0005334_abnormal_fat_pad0.69187296
59MP0001661_extended_life_span0.68081953
60MP0006036_abnormal_mitochondrial_physio0.68035796
61MP0003724_increased_susceptibility_to0.66126908
62MP0000639_abnormal_adrenal_gland0.65053202
63MP0004130_abnormal_muscle_cell0.64416148
64MP0002282_abnormal_trachea_morphology0.62333447
65MP0001756_abnormal_urination0.59895657
66MP0005535_abnormal_body_temperature0.58129159
67MP0002136_abnormal_kidney_physiology0.57267847
68MP0005395_other_phenotype0.56775628
69MP0003075_altered_response_to0.56516029
70MP0008873_increased_physiological_sensi0.55574655
71MP0005166_decreased_susceptibility_to0.54279354
72MP0000566_synostosis0.54014511
73MP0002089_abnormal_postnatal_growth/wei0.53720703
74MP0002876_abnormal_thyroid_physiology0.53465513
75MP0005023_abnormal_wound_healing0.52523907
76MP0005448_abnormal_energy_balance0.50445898
77MP0003638_abnormal_response/metabolism_0.49811404
78MP0008874_decreased_physiological_sensi0.48874422
79MP0002249_abnormal_larynx_morphology0.48500434
80MP0005666_abnormal_adipose_tissue0.47580329
81MP0005164_abnormal_response_to0.46601442
82MP0005266_abnormal_metabolism0.45795473
83MP0000579_abnormal_nail_morphology0.45246745
84MP0001845_abnormal_inflammatory_respons0.45087130
85MP0004883_abnormal_blood_vessel0.44831342
86MP0000249_abnormal_blood_vessel0.43031720
87MP0009384_cardiac_valve_regurgitation0.42278202
88MP0009785_altered_susceptibility_to0.42191675
89MP0008872_abnormal_physiological_respon0.41353917
90MP0003122_maternal_imprinting0.40267571
91MP0002796_impaired_skin_barrier0.38830833
92MP0002168_other_aberrant_phenotype0.38309197
93MP0009115_abnormal_fat_cell0.37351041
94MP0004264_abnormal_extraembryonic_tissu0.37104968
95MP0002135_abnormal_kidney_morphology0.35774817
96MP0003453_abnormal_keratinocyte_physiol0.35004532
97MP0003718_maternal_effect0.34323445
98MP0003953_abnormal_hormone_level0.33983834
99MP0005025_abnormal_response_to0.33831435
100MP0005167_abnormal_blood-brain_barrier0.33536794
101MP0003172_abnormal_lysosome_physiology0.33481274
102MP0003300_gastrointestinal_ulcer0.33210544
103MP0001243_abnormal_dermal_layer0.32331730
104MP0006035_abnormal_mitochondrial_morpho0.32242886
105MP0006082_CNS_inflammation0.32070896
106MP0005058_abnormal_lysosome_morphology0.31850485
107MP0003303_peritoneal_inflammation0.31664802
108MP0002419_abnormal_innate_immunity0.31406297
109MP0002970_abnormal_white_adipose0.31385802
110MP0002928_abnormal_bile_duct0.30334820
111MP0005248_abnormal_Harderian_gland0.28897294
112MP0004272_abnormal_basement_membrane0.27028440
113MP0000920_abnormal_myelination0.25382828
114MP0002090_abnormal_vision0.25342854
115MP0003959_abnormal_lean_body0.23390517
116MP0001851_eye_inflammation0.20778480
117MP0003632_abnormal_nervous_system0.20773518
118MP0005197_abnormal_uvea_morphology0.19777515
119MP0002128_abnormal_blood_circulation0.19617342
120MP0000467_abnormal_esophagus_morphology0.18833507

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.43046313
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.15179686
3Abnormality of monocarboxylic acid metabolism (HP:0010996)7.06148793
4Prolonged partial thromboplastin time (HP:0003645)6.78732659
5Intrahepatic cholestasis (HP:0001406)6.51959955
6Complement deficiency (HP:0004431)6.39642166
7Hypobetalipoproteinemia (HP:0003563)5.98611070
8Xanthomatosis (HP:0000991)5.98309580
9Hyperlipoproteinemia (HP:0010980)5.65239786
10Abnormality of the common coagulation pathway (HP:0010990)5.48355467
11Joint hemorrhage (HP:0005261)5.16607343
12Spontaneous abortion (HP:0005268)4.93809287
13Abnormality of complement system (HP:0005339)4.69112354
14Hypolipoproteinemia (HP:0010981)4.66960334
15Hyperammonemia (HP:0001987)4.34464974
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.32113956
17Abnormality of methionine metabolism (HP:0010901)4.27715853
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.26394703
19Hypoalphalipoproteinemia (HP:0003233)4.25661273
20Epidermoid cyst (HP:0200040)4.20627994
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.14580504
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.08435099
23Abnormality of pyrimidine metabolism (HP:0004353)4.03392461
24Ketosis (HP:0001946)3.94486614
25Abnormality of the intrinsic pathway (HP:0010989)3.85588611
26Fat malabsorption (HP:0002630)3.83544957
27Hypoglycemic coma (HP:0001325)3.72409362
28Hyperglycinemia (HP:0002154)3.68016316
29Hypercholesterolemia (HP:0003124)3.52841796
30Amyloidosis (HP:0011034)3.51397676
31Gingival bleeding (HP:0000225)3.48287648
32Glomerulonephritis (HP:0000099)3.32503174
33Systemic lupus erythematosus (HP:0002725)3.28913848
34Conjugated hyperbilirubinemia (HP:0002908)3.25014004
35Hyperglycinuria (HP:0003108)3.23313523
36Abnormality of glycine metabolism (HP:0010895)3.20073473
37Abnormality of serine family amino acid metabolism (HP:0010894)3.20073473
38Abnormality of nucleobase metabolism (HP:0010932)3.19029597
39Hyperbilirubinemia (HP:0002904)2.98650711
40Steatorrhea (HP:0002570)2.97457158
41Myocardial infarction (HP:0001658)2.97040030
42Generalized aminoaciduria (HP:0002909)2.94985087
43Recurrent gram-negative bacterial infections (HP:0005420)2.91286851
44Purpura (HP:0000979)2.90556983
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.86831365
46Abnormality of iron homeostasis (HP:0011031)2.85728335
47Abnormality of fatty-acid metabolism (HP:0004359)2.83084769
48Ketoacidosis (HP:0001993)2.80669382
49Abnormality of purine metabolism (HP:0004352)2.76848165
50Osteomalacia (HP:0002749)2.76712390
51Thrombophlebitis (HP:0004418)2.72536644
52Abnormality of transition element cation homeostasis (HP:0011030)2.68807107
53Hepatocellular carcinoma (HP:0001402)2.68122502
54Abnormality of serum amino acid levels (HP:0003112)2.67044050
55Skin nodule (HP:0200036)2.64096533
56Hypochromic microcytic anemia (HP:0004840)2.61228777
57Mitral stenosis (HP:0001718)2.61223366
58Reduced antithrombin III activity (HP:0001976)2.57947537
59Vascular calcification (HP:0004934)2.56124104
60Hypoglycemic seizures (HP:0002173)2.55842411
61Nephritis (HP:0000123)2.52683031
62Lethargy (HP:0001254)2.49264958
63Spastic diplegia (HP:0001264)2.42958723
64Late onset (HP:0003584)2.40544571
65Cerebral edema (HP:0002181)2.40500399
66Delayed CNS myelination (HP:0002188)2.38847940
67Gout (HP:0001997)2.38837944
68Metabolic acidosis (HP:0001942)2.37827392
69Irritability (HP:0000737)2.36804548
70Menorrhagia (HP:0000132)2.36211865
71Neonatal onset (HP:0003623)2.35894385
72Cardiovascular calcification (HP:0011915)2.28143761
73Esophageal varix (HP:0002040)2.23906349
74Arthropathy (HP:0003040)2.19788889
75Abnormal gallbladder morphology (HP:0012437)2.19582943
76Joint swelling (HP:0001386)2.19524992
77Cholecystitis (HP:0001082)2.18095075
78Abnormal gallbladder physiology (HP:0012438)2.18095075
79Cholelithiasis (HP:0001081)2.15961687
80Hyperinsulinemic hypoglycemia (HP:0000825)2.11691179
81Acanthocytosis (HP:0001927)2.04902361
82Abnormality of the Achilles tendon (HP:0005109)2.04692954
83Hyperphosphaturia (HP:0003109)2.04046904
84Dicarboxylic aciduria (HP:0003215)2.03766762
85Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03766762
86Fair hair (HP:0002286)2.03314328
87Pancreatitis (HP:0001733)2.00266676
88Vomiting (HP:0002013)1.98116709
89Gangrene (HP:0100758)1.96668351
90Sensorimotor neuropathy (HP:0007141)1.95211036
91Opisthotonus (HP:0002179)1.95168524
92Enlarged kidneys (HP:0000105)1.90448277
93Hyperglycemia (HP:0003074)1.88552944
94Epistaxis (HP:0000421)1.88193737
95Brushfield spots (HP:0001088)1.88111399
96Abnormality of urine glucose concentration (HP:0011016)1.85064612
97Glycosuria (HP:0003076)1.85064612
98Hemorrhage of the eye (HP:0011885)1.83543597
99Elevated alkaline phosphatase (HP:0003155)1.83408295
100Rickets (HP:0002748)1.81506961
101Alkalosis (HP:0001948)1.81432828
102Bifid scrotum (HP:0000048)1.80852686
103Increased serum ferritin (HP:0003281)1.80691982
104Malnutrition (HP:0004395)1.79086975
105Hypophosphatemic rickets (HP:0004912)1.78006719
106Abnormality of the gallbladder (HP:0005264)1.77752734
107Abnormal cartilage morphology (HP:0002763)1.76123878
108Symptomatic seizures (HP:0011145)1.74820150
109Pulmonary embolism (HP:0002204)1.74113631
110Abnormality of vitamin metabolism (HP:0100508)1.72887613
111Back pain (HP:0003418)1.70341471
112Hypertriglyceridemia (HP:0002155)1.70104476
113Abnormality of alkaline phosphatase activity (HP:0004379)1.69520143
114Hydroxyprolinuria (HP:0003080)1.68721852
115Abnormality of proline metabolism (HP:0010907)1.68721852
116Neonatal hypoglycemia (HP:0001998)1.67555431
117Abnormal enzyme/coenzyme activity (HP:0012379)1.67490480
118Abnormal urine phosphate concentration (HP:0012599)1.66519542
119Increased serum pyruvate (HP:0003542)1.66490659
120Poikilocytosis (HP:0004447)1.65723713
121Abnormal tarsal ossification (HP:0008369)1.65507129
122Abnormal delivery (HP:0001787)1.64467141
123Increased mean platelet volume (HP:0011877)1.59670159
124Abnormal platelet function (HP:0011869)1.52976730
125Impaired platelet aggregation (HP:0003540)1.52976730
126Potter facies (HP:0002009)1.52862374
127Facial shape deformation (HP:0011334)1.52862374
128Abnormal biliary tract physiology (HP:0012439)1.52602745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.29396211
2ERN15.99437525
3FGFR44.94681933
4SIK13.32783284
5ERBB43.10506540
6TAOK33.03008049
7DAPK22.60913592
8INSRR2.35959693
9EPHB12.10224136
10EPHA32.06181680
11MAP2K42.04948267
12TRIB32.03524684
13MST1R1.86265699
14PTK61.82286019
15TYK21.81977557
16PIK3CG1.78342772
17MAPK111.77806716
18PRPF4B1.57231980
19NTRK31.49815081
20NEK91.42469848
21PKN21.39572738
22JAK21.39296693
23TBK11.38054947
24GRK61.33976328
25CDK121.32903337
26JAK11.24644542
27ABL21.20643535
28ERBB21.18802817
29EIF2AK11.14382597
30MAP3K141.14006083
31LATS11.12423987
32RIPK11.11045603
33PIK3CA1.09817839
34FLT31.09737785
35MAP3K21.08955103
36PDGFRA1.08471258
37MAP3K71.06913395
38FRK1.06544013
39CAMK1D1.04216318
40IRAK31.02369458
41MAPK120.94886620
42PRKAA20.94386543
43WNK40.94318928
44MAP3K110.92225480
45CAMK2G0.91675638
46FGFR10.88191546
47FGFR20.84179774
48MAPK40.82313851
49AKT30.81714757
50PRKG10.81109647
51TNK20.80723109
52TGFBR20.80463884
53KDR0.80168961
54PRKCZ0.79245641
55MAP2K30.78556497
56MET0.77555065
57IKBKE0.77403130
58PRKACG0.77055189
59FGFR30.75162357
60MAP2K10.71554874
61SGK10.70263848
62MAPKAPK30.69862799
63MAP3K30.68847515
64CAMKK20.68458114
65CSNK1D0.66704646
66CSK0.64964315
67MAP2K60.64865132
68DYRK1B0.63417970
69PRKACA0.63217902
70TAOK20.62902253
71PKN10.62373510
72GSK3A0.62049340
73SCYL20.60941456
74PDK20.60889072
75MAP3K130.59173725
76CSF1R0.58974116
77PTK20.58364194
78CDK40.57716313
79MAP3K120.55792812
80CDK60.53849711
81CAMKK10.53616029
82PDPK10.53558782
83RPS6KA30.53427182
84KSR20.53373696
85MAP3K50.52818841
86SGK20.52177674
87PRKCB0.52170567
88PINK10.51298573
89SRC0.48837508
90CAMK1G0.48756626
91MAP3K100.48541903
92RET0.48412362
93EGFR0.47461614
94IGF1R0.46316553
95CSNK2A20.46196394
96EPHA40.45121679
97MAPK150.44048508
98MAPK70.43643286
99MAP3K60.42802374
100MAP3K10.42626891
101PRKCQ0.42436983
102CSNK2A10.42011344
103BMX0.41896760
104MAP4K10.41062908
105PRKCG0.40868739
106CAMK40.39900291
107MTOR0.39138480
108EPHA20.38960335
109IRAK10.38273078
110SGK30.37811063
111RPS6KB10.37475231
112KIT0.36995172
113PRKAA10.36697715
114BLK0.36112853
115CDK70.34781860
116MYLK0.34198777
117ZAP700.33947922
118STK38L0.33641187
119ICK0.33513666
120DAPK30.33442765
121TIE10.32545058
122PAK30.32496523
123PDK10.32137502
124MAPK30.31553863
125NLK0.29084529
126PRKACB0.28452049
127PRKCA0.27401476
128FER0.26537232
129CSNK1E0.26177404
130IKBKB0.25715935
131CSNK1G10.25629810
132SGK4940.25194946
133SGK2230.25194946
134JAK30.23612993
135EPHB20.23537100
136PRKCH0.22343139

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.44650672
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.89278516
3Arginine biosynthesis_Homo sapiens_hsa002203.47801578
4Complement and coagulation cascades_Homo sapiens_hsa046103.45701445
5Nitrogen metabolism_Homo sapiens_hsa009103.31055657
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.02022274
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.60287289
8Tryptophan metabolism_Homo sapiens_hsa003802.57719081
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.39357093
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.32516201
11Staphylococcus aureus infection_Homo sapiens_hsa051502.32497911
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.31578860
13Fatty acid degradation_Homo sapiens_hsa000712.17095239
14Caffeine metabolism_Homo sapiens_hsa002322.16629256
15Chemical carcinogenesis_Homo sapiens_hsa052042.12932903
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10066735
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.02076402
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.01223341
19Peroxisome_Homo sapiens_hsa041462.00544004
20PPAR signaling pathway_Homo sapiens_hsa033201.86058917
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.80248403
22Butanoate metabolism_Homo sapiens_hsa006501.79885746
23Histidine metabolism_Homo sapiens_hsa003401.78941246
24Propanoate metabolism_Homo sapiens_hsa006401.72734107
25Phenylalanine metabolism_Homo sapiens_hsa003601.69810289
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.64869261
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60380956
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.59214777
29Fatty acid metabolism_Homo sapiens_hsa012121.55389323
30Selenocompound metabolism_Homo sapiens_hsa004501.55055129
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50084411
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.49453234
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49334849
34beta-Alanine metabolism_Homo sapiens_hsa004101.47110112
35Tyrosine metabolism_Homo sapiens_hsa003501.44378130
36Retinol metabolism_Homo sapiens_hsa008301.44111008
37Bile secretion_Homo sapiens_hsa049761.42234516
38Folate biosynthesis_Homo sapiens_hsa007901.40708742
39Steroid biosynthesis_Homo sapiens_hsa001001.38361613
40Biosynthesis of amino acids_Homo sapiens_hsa012301.33293870
41Fat digestion and absorption_Homo sapiens_hsa049751.29034001
42Pyruvate metabolism_Homo sapiens_hsa006201.25414336
43Starch and sucrose metabolism_Homo sapiens_hsa005001.22744848
44Sulfur metabolism_Homo sapiens_hsa009201.18110672
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14828011
46ABC transporters_Homo sapiens_hsa020101.13867231
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.12075578
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11087628
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08798549
50Carbon metabolism_Homo sapiens_hsa012001.07891927
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.07809337
52Arachidonic acid metabolism_Homo sapiens_hsa005900.98689844
53Vitamin digestion and absorption_Homo sapiens_hsa049770.95972839
54Glutathione metabolism_Homo sapiens_hsa004800.95172416
55Fatty acid elongation_Homo sapiens_hsa000620.94755199
56Sulfur relay system_Homo sapiens_hsa041220.94376359
57Arginine and proline metabolism_Homo sapiens_hsa003300.91323276
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88730606
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87468329
60Fatty acid biosynthesis_Homo sapiens_hsa000610.83581386
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82293921
62Vitamin B6 metabolism_Homo sapiens_hsa007500.80143558
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69176908
64Lysine degradation_Homo sapiens_hsa003100.64167247
65Pentose phosphate pathway_Homo sapiens_hsa000300.62599106
66One carbon pool by folate_Homo sapiens_hsa006700.55841148
67Glycerolipid metabolism_Homo sapiens_hsa005610.53805922
68Prion diseases_Homo sapiens_hsa050200.51207940
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44812034
70Metabolic pathways_Homo sapiens_hsa011000.40965100
71Galactose metabolism_Homo sapiens_hsa000520.38148769
72Fructose and mannose metabolism_Homo sapiens_hsa000510.32212451
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.26733819
74Insulin resistance_Homo sapiens_hsa049310.24778447
75Other glycan degradation_Homo sapiens_hsa005110.21560501
76Glucagon signaling pathway_Homo sapiens_hsa049220.11900464
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11069098
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.10274917
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08898722
80Linoleic acid metabolism_Homo sapiens_hsa005910.05290135
81AMPK signaling pathway_Homo sapiens_hsa041520.03389851
82Type II diabetes mellitus_Homo sapiens_hsa04930-0.2274566
83Prolactin signaling pathway_Homo sapiens_hsa04917-0.2253440
84Circadian rhythm_Homo sapiens_hsa04710-0.2204712
85Regulation of autophagy_Homo sapiens_hsa04140-0.2113419
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1986999
87Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1844379
88Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1783617
89Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1758304
90Renin-angiotensin system_Homo sapiens_hsa04614-0.1662359
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1644318
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1593605
93Sphingolipid metabolism_Homo sapiens_hsa00600-0.1513230
94Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1474625
95Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1447317
96Amoebiasis_Homo sapiens_hsa05146-0.1352317
97Bladder cancer_Homo sapiens_hsa05219-0.1192990
98Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1150393
99Serotonergic synapse_Homo sapiens_hsa04726-0.0995704
100Insulin signaling pathway_Homo sapiens_hsa04910-0.0899094
101N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0819779
102Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0808390
103Pertussis_Homo sapiens_hsa05133-0.0786101
104Hepatitis C_Homo sapiens_hsa05160-0.0666101
105African trypanosomiasis_Homo sapiens_hsa05143-0.0600969
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0501215
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0400187
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0307889
109Mineral absorption_Homo sapiens_hsa04978-0.0154830

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