ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	alpha-linolenic acid metabolic process (GO:0036109)	5.47526514
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.00756182
3	L-phenylalanine catabolic process (GO:0006559)	5.00756182
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.99438221
5	L-phenylalanine metabolic process (GO:0006558)	4.99438221
6	valine metabolic process (GO:0006573)	4.94264466
7	regulation of sequestering of triglyceride (GO:0010889)	4.83798754
8	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.81866699
9	positive regulation of fatty acid beta-oxidation (GO:0032000)	4.73449315
10	regulation of triglyceride catabolic process (GO:0010896)	4.65419483
11	sulfur amino acid catabolic process (GO:0000098)	4.63739924
12	fatty acid beta-oxidation (GO:0006635)	4.41823633
13	positive regulation of fatty acid oxidation (GO:0046321)	4.38959577
14	biotin metabolic process (GO:0006768)	4.37610519
15	very-low-density lipoprotein particle assembly (GO:0034379)	4.30305060
16	regulation of fatty acid beta-oxidation (GO:0031998)	4.23568941
17	triglyceride catabolic process (GO:0019433)	4.21211182
18	low-density lipoprotein particle clearance (GO:0034383)	4.19385645
19	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.18545809
20	fatty acid oxidation (GO:0019395)	4.18307868
21	lysine metabolic process (GO:0006553)	4.17331911
22	lysine catabolic process (GO:0006554)	4.17331911
23	plasma lipoprotein particle assembly (GO:0034377)	4.14398430
24	acylglycerol catabolic process (GO:0046464)	4.13953167
25	neutral lipid catabolic process (GO:0046461)	4.13953167
26	fatty acid transmembrane transport (GO:1902001)	4.13879557
27	lipid oxidation (GO:0034440)	4.10206666
28	aromatic amino acid family catabolic process (GO:0009074)	4.09482254
29	fatty acid catabolic process (GO:0009062)	4.06674077
30	complement activation, alternative pathway (GO:0006957)	4.06319096
31	cysteine metabolic process (GO:0006534)	4.05451768
32	triglyceride homeostasis (GO:0070328)	4.04734367
33	acylglycerol homeostasis (GO:0055090)	4.04734367
34	regulation of fatty acid oxidation (GO:0046320)	3.98230077
35	positive regulation of lipid catabolic process (GO:0050996)	3.98194810
36	regulation of cholesterol esterification (GO:0010872)	3.94551728
37	protein-lipid complex assembly (GO:0065005)	3.91605619
38	regulation of plasminogen activation (GO:0010755)	3.91154958
39	2-oxoglutarate metabolic process (GO:0006103)	3.87085722
40	plasma lipoprotein particle clearance (GO:0034381)	3.86343915
41	acetyl-CoA metabolic process (GO:0006084)	3.84493040
42	carnitine shuttle (GO:0006853)	3.84266715
43	bile acid biosynthetic process (GO:0006699)	3.82559583
44	high-density lipoprotein particle remodeling (GO:0034375)	3.82309353
45	short-chain fatty acid metabolic process (GO:0046459)	3.82195874
46	amino-acid betaine metabolic process (GO:0006577)	3.81633267
47	branched-chain amino acid catabolic process (GO:0009083)	3.80341752
48	protein carboxylation (GO:0018214)	3.73969166
49	peptidyl-glutamic acid carboxylation (GO:0017187)	3.73969166
50	monocarboxylic acid catabolic process (GO:0072329)	3.73150548
51	blood coagulation, intrinsic pathway (GO:0007597)	3.72587450
52	positive regulation of triglyceride metabolic process (GO:0090208)	3.72272916
53	urea cycle (GO:0000050)	3.70808934
54	urea metabolic process (GO:0019627)	3.70808934
55	regulation of apoptotic cell clearance (GO:2000425)	3.69688679
56	branched-chain amino acid metabolic process (GO:0009081)	3.69428279
57	reverse cholesterol transport (GO:0043691)	3.69388634
58	negative regulation of fibrinolysis (GO:0051918)	3.69200081
59	positive regulation of triglyceride lipase activity (GO:0061365)	3.68497378
60	positive regulation of lipoprotein lipase activity (GO:0051006)	3.68497378
61	ethanol oxidation (GO:0006069)	3.66977380
62	regulation of protein activation cascade (GO:2000257)	3.63520540
63	ethanol metabolic process (GO:0006067)	3.60953545
64	glyoxylate metabolic process (GO:0046487)	3.59190141
65	regulation of extracellular matrix disassembly (GO:0010715)	3.58447929
66	serine family amino acid catabolic process (GO:0009071)	3.58007956
67	positive regulation of extracellular matrix organization (GO:1903055)	3.56219029
68	kynurenine metabolic process (GO:0070189)	3.55860260
69	fibrinolysis (GO:0042730)	3.55751581
70	positive regulation of fatty acid metabolic process (GO:0045923)	3.54539559
71	diacylglycerol metabolic process (GO:0046339)	3.54383479
72	regulation of cholesterol homeostasis (GO:2000188)	3.51361986
73	homocysteine metabolic process (GO:0050667)	3.47703193
74	regulation of complement activation (GO:0030449)	3.47501994
75	intestinal cholesterol absorption (GO:0030299)	3.46315812
76	regulation of triglyceride metabolic process (GO:0090207)	3.46091357
77	negative regulation of lipase activity (GO:0060192)	3.41250745
78	complement activation, classical pathway (GO:0006958)	3.41149885
79	nitrogen cycle metabolic process (GO:0071941)	3.40515647
80	thioester biosynthetic process (GO:0035384)	3.39679234
81	acyl-CoA biosynthetic process (GO:0071616)	3.39679234
82	proline metabolic process (GO:0006560)	3.39563094
83	acute-phase response (GO:0006953)	3.39213381
84	bile acid metabolic process (GO:0008206)	3.39209999
85	protein activation cascade (GO:0072376)	3.37837925
86	tryptophan catabolic process (GO:0006569)	3.36751069
87	indole-containing compound catabolic process (GO:0042436)	3.36751069
88	indolalkylamine catabolic process (GO:0046218)	3.36751069
89	regulation of fibrinolysis (GO:0051917)	3.35273430
90	regulation of extracellular matrix organization (GO:1903053)	3.34867848
91	protein-lipid complex remodeling (GO:0034368)	3.33586680
92	macromolecular complex remodeling (GO:0034367)	3.33586680
93	plasma lipoprotein particle remodeling (GO:0034369)	3.33586680
94	cholesterol efflux (GO:0033344)	3.33473149
95	tricarboxylic acid metabolic process (GO:0072350)	3.33185256
96	plasma lipoprotein particle organization (GO:0071827)	3.31704997
97	alpha-amino acid catabolic process (GO:1901606)	3.31591181
98	low-density lipoprotein particle remodeling (GO:0034374)	3.31222808
99	carnitine metabolic process (GO:0009437)	3.29942300
100	organic acid catabolic process (GO:0016054)	3.28736786
101	carboxylic acid catabolic process (GO:0046395)	3.28736786
102	regulation of triglyceride biosynthetic process (GO:0010866)	3.27670535
103	cellular amino acid catabolic process (GO:0009063)	3.27342598
104	positive regulation of blood coagulation (GO:0030194)	3.25668063
105	positive regulation of hemostasis (GO:1900048)	3.25668063
106	protein-lipid complex subunit organization (GO:0071825)	3.24284278
107	regulation of lipid catabolic process (GO:0050994)	3.23806654
108	triglyceride metabolic process (GO:0006641)	3.23572256
109	fatty-acyl-CoA biosynthetic process (GO:0046949)	3.20572516
110	oxaloacetate metabolic process (GO:0006107)	3.19095737
111	complement activation (GO:0006956)	3.18301813
112	NADH metabolic process (GO:0006734)	3.17652544
113	tryptophan metabolic process (GO:0006568)	3.17537509
114	epoxygenase P450 pathway (GO:0019373)	3.17448933
115	cellular ketone body metabolic process (GO:0046950)	3.16753908
116	regulation of cholesterol storage (GO:0010885)	3.16732066
117	cellular modified amino acid catabolic process (GO:0042219)	3.16504020
118	negative regulation of cholesterol transport (GO:0032375)	3.15409852
119	negative regulation of sterol transport (GO:0032372)	3.15409852
120	positive regulation of triglyceride biosynthetic process (GO:0010867)	3.15108799
121	phospholipid efflux (GO:0033700)	3.13572868
122	fatty acid homeostasis (GO:0055089)	3.12129288
123	regulation of cholesterol biosynthetic process (GO:0045540)	3.11356906
124	acylglycerol metabolic process (GO:0006639)	3.10512408
125	regulation of humoral immune response (GO:0002920)	3.09858821
126	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	3.09342658
127	carnitine transmembrane transport (GO:1902603)	3.09294563
128	regulation of bile acid biosynthetic process (GO:0070857)	3.08418231
129	tyrosine metabolic process (GO:0006570)	3.07914710
130	negative regulation of blood coagulation (GO:0030195)	3.07768744
131	negative regulation of hemostasis (GO:1900047)	3.07768744
132	coenzyme catabolic process (GO:0009109)	3.07690682
133	neutral lipid metabolic process (GO:0006638)	3.06013290
134	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.02584029
135	positive regulation of coagulation (GO:0050820)	3.01149306
136	negative regulation of protein activation cascade (GO:2000258)	2.98834682
137	regulation of cholesterol metabolic process (GO:0090181)	2.91829323
138	progesterone metabolic process (GO:0042448)	2.90532767
139	intestinal absorption (GO:0050892)	2.87927396
140	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.84432020
141	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	2.79497813
142	negative regulation of fatty acid transport (GO:2000192)	2.78695267
143	proline biosynthetic process (GO:0006561)	2.78486613
144	negative regulation of lipid transport (GO:0032369)	2.76577957
145	exogenous drug catabolic process (GO:0042738)	2.74989135
146	negative regulation of coagulation (GO:0050819)	2.72841305
147	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	2.67444204
148	negative regulation of wound healing (GO:0061045)	2.67167049
149	lipoprotein metabolic process (GO:0042157)	2.67089166
150	basement membrane organization (GO:0071711)	2.66597818
151	Golgi transport vesicle coating (GO:0048200)	2.65044110
152	COPI coating of Golgi vesicle (GO:0048205)	2.65044110
153	glutamate metabolic process (GO:0006536)	2.64109768
154	regulation of glucose import in response to insulin stimulus (GO:2001273)	2.61807257
155	response to mercury ion (GO:0046689)	2.59528120
156	cellular glucuronidation (GO:0052695)	2.54786827
157	positive regulation of steroid metabolic process (GO:0045940)	2.54691951
158	acute inflammatory response (GO:0002526)	2.54292834
159	cholesterol homeostasis (GO:0042632)	2.50249454
160	negative regulation of complement activation (GO:0045916)	2.50246983
161	positive regulation of fatty acid biosynthetic process (GO:0045723)	2.49872537

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	8.07076054
2	* PPARG_19300518_ChIP-PET_3T3-L1_Mouse	8.00372720
3	* RXR_22158963_ChIP-Seq_LIVER_Mouse	6.05357929
4	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	5.28831072
5	* LXR_22158963_ChIP-Seq_LIVER_Mouse	4.72495060
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	3.88660927
7	* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	3.88097890
8	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.37833141
9	CLOCK_20551151_ChIP-Seq_293T_Human	3.28990616
10	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.16250975
11	* CEBPA_23403033_ChIP-Seq_LIVER_Mouse	3.08233945
12	ZNF263_19887448_ChIP-Seq_K562_Human	2.37990390
13	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.14512964
14	MYC_22102868_ChIP-Seq_BL_Human	2.08837129
15	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.06565501
16	* TCF7_22412390_ChIP-Seq_EML_Mouse	1.95554178
17	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.88876304
18	GATA1_22025678_ChIP-Seq_K562_Human	1.87073063
19	VDR_21846776_ChIP-Seq_THP-1_Human	1.80502641
20	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.72418547
21	* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.58812315
22	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.52542292
23	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.51362890
24	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.48101721
25	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.46310758
26	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.43883968
27	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.43874842
28	* ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.41747248
29	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.41434105
30	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.37489878
31	LXR_22292898_ChIP-Seq_THP-1_Human	1.36215658
32	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.31452479
33	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.30783131
34	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.29708211
35	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.28487784
36	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.28220906
37	MAF_26560356_Chip-Seq_TH1_Human	1.27160688
38	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.25578138
39	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.24505290
40	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.22490693
41	* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.21836646
42	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.21545418
43	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.20822919
44	VDR_24763502_ChIP-Seq_THP-1_Human	1.20162818
45	* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.19844934
46	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.19231541
47	* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.17779738
48	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.17719369
49	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.17193933
50	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.16026834
51	* SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.15750727
52	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.14997692
53	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.13610005
54	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.13607044
55	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.10491744
56	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.10371184
57	* UTX_26944678_Chip-Seq_JUKART_Human	1.09063221
58	* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.07875305
59	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.07852239
60	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.07338711
61	* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.06647748
62	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.03650462
63	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.02449773
64	MAF_26560356_Chip-Seq_TH2_Human	1.01605234
65	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.00068279
66	NCOR1_26117541_ChIP-Seq_K562_Human	1.00061763
67	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.99987933
68	GATA1_19941826_ChIP-Seq_K562_Human	0.99392585
69	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.98772486
70	RACK7_27058665_Chip-Seq_MCF-7_Human	0.98290781
71	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.98229384
72	* HNF4A_19822575_ChIP-Seq_HepG2_Human	0.97710474
73	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.97597330
74	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.95958462
75	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.95749610
76	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.94602604
77	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.94560534
78	GATA6_25053715_ChIP-Seq_YYC3_Human	0.94500536
79	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.94171231
80	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.94079031
81	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.94079031
82	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.93573893
83	* ERG_21242973_ChIP-ChIP_JURKAT_Human	0.93368600
84	CREB1_26743006_Chip-Seq_LNCaP_Human	0.92916780
85	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.92364081
86	FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human	0.89577794
87	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.89024995
88	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.88649291
89	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.88624317
90	KDM2B_26808549_Chip-Seq_K562_Human	0.88062340
91	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.87920568
92	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.87055469
93	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.86984152
94	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.86525510
95	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.85903471
96	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.84244629
97	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.84010576
98	* ATF3_27146783_Chip-Seq_COLON_Human	0.83998863
99	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.83600308
100	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.82417866
101	* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.81358413
102	* SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.79984817
103	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.79879598
104	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.79131630
105	* P68_20966046_ChIP-Seq_HELA_Human	0.77556357
106	GATA4_25053715_ChIP-Seq_YYC3_Human	0.76945796
107	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.76918099
108	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.74658487
109	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.74422003
110	* GATA1_19941827_ChIP-Seq_MEL_Mouse	0.74086066
111	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.73703142
112	* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.72564499
113	* RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.72441327
114	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.72126229
115	* SMC4_20622854_ChIP-Seq_HELA_Human	0.72090710
116	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.71935140
117	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.71832417
118	GATA2_19941826_ChIP-Seq_K562_Human	0.71749038
119	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.71243254
120	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.71110170
121	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.70909815
122	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.70890028
123	* TP63_22573176_ChIP-Seq_HFKS_Human	0.70241563
124	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.70230099
125	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.68447354
126	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.68118664
127	* RARB_24833708_ChIP-Seq_LIVER_Mouse	0.68108801
128	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.68083542
129	* BCOR_27268052_Chip-Seq_Bcells_Human	0.68063145
130	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.67496774
131	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.67043436
132	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.65267086
133	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.63657185
134	CTCF_27219007_Chip-Seq_Bcells_Human	0.63267280
135	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.62277889
136	* RARA_24833708_ChIP-Seq_LIVER_Mouse	0.62250733
137	KDM2B_26808549_Chip-Seq_DND41_Human	0.61088677
138	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.61046336
139	KLF4_19829295_ChIP-Seq_ESCs_Human	0.60809197
140	CTCF_21964334_Chip-Seq_Bcells_Human	0.59855020

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	5.87924118
2	MP0005365_abnormal_bile_salt	4.98081436
3	MP0005360_urolithiasis	4.83302185
4	MP0005670_abnormal_white_adipose	4.07211021
5	MP0005085_abnormal_gallbladder_physiolo	4.06617967
6	MP0010329_abnormal_lipoprotein_level	3.66021153
7	MP0008875_abnormal_xenobiotic_pharmacok	3.25288109
8	MP0004130_abnormal_muscle_cell	3.04425713
9	MP0003252_abnormal_bile_duct	2.84738532
10	MP0005666_abnormal_adipose_tissue	2.79864310
11	MP0005451_abnormal_body_composition	2.67445345
12	MP0009840_abnormal_foam_cell	2.45713174
13	MP0003806_abnormal_nucleotide_metabolis	2.45470528
14	MP0002118_abnormal_lipid_homeostasis	2.40946890
15	MP0003191_abnormal_cellular_cholesterol	2.32249306
16	MP0003705_abnormal_hypodermis_morpholog	2.30421648
17	MP0001666_abnormal_nutrient_absorption	2.28946448
18	MP0005332_abnormal_amino_acid	2.27304336
19	MP0004185_abnormal_adipocyte_glucose	2.16410531
20	MP0005375_adipose_tissue_phenotype	2.12359460
21	MP0000609_abnormal_liver_physiology	2.09690261
22	MP0002971_abnormal_brown_adipose	2.08951518
23	MP0003195_calcinosis	2.01944300
24	MP0008438_abnormal_cutaneous_collagen	2.01215242
25	MP0005083_abnormal_biliary_tract	1.98711385
26	MP0000013_abnormal_adipose_tissue	1.92914345
27	MP0002837_dystrophic_cardiac_calcinosis	1.91181213
28	MP0003566_abnormal_cell_adhesion	1.88505690
29	MP0003436_decreased_susceptibility_to	1.76859829
30	MP0001984_abnormal_olfaction	1.74493434
31	MP0002138_abnormal_hepatobiliary_system	1.71365504
32	MP0000858_altered_metastatic_potential	1.70879138
33	MP0005319_abnormal_enzyme/_coenzyme	1.69825224
34	MP0003011_delayed_dark_adaptation	1.67757423
35	MP0000003_abnormal_adipose_tissue	1.67685770
36	MP0002132_abnormal_respiratory_system	1.65690758
37	MP0002909_abnormal_adrenal_gland	1.57090628
38	MP0005584_abnormal_enzyme/coenzyme_acti	1.55908331
39	MP0005334_abnormal_fat_pad	1.54887259
40	MP0005275_abnormal_skin_tensile	1.53945910
41	MP0005409_darkened_coat_color	1.53402372
42	MP0008260_abnormal_autophagy	1.52195078
43	MP0005464_abnormal_platelet_physiology	1.50309517
44	MP0001661_extended_life_span	1.48062658
45	MP0002078_abnormal_glucose_homeostasis	1.47242254
46	MP0005535_abnormal_body_temperature	1.47234424
47	MP0003172_abnormal_lysosome_physiology	1.47033256
48	MP0004019_abnormal_vitamin_homeostasis	1.47007456
49	MP0004264_abnormal_extraembryonic_tissu	1.45990635
50	MP0005257_abnormal_intraocular_pressure	1.41951305
51	MP0002089_abnormal_postnatal_growth/wei	1.36300700
52	MP0003868_abnormal_feces_composition	1.35550134
53	MP0003303_peritoneal_inflammation	1.35203623
54	MP0006036_abnormal_mitochondrial_physio	1.33180094
55	MP0009643_abnormal_urine_homeostasis	1.33042394
56	MP0005076_abnormal_cell_differentiation	1.31909287
57	MP0002166_altered_tumor_susceptibility	1.30760703
58	MP0000685_abnormal_immune_system	1.30599414
59	MP0001764_abnormal_homeostasis	1.30074978
60	MP0003091_abnormal_cell_migration	1.26616829
61	MP0005448_abnormal_energy_balance	1.25654361
62	MP0003183_abnormal_peptide_metabolism	1.25438691
63	MP0009115_abnormal_fat_cell	1.25295724
64	MP0002970_abnormal_white_adipose	1.23867465
65	MP0008961_abnormal_basal_metabolism	1.23500136
66	MP0001849_ear_inflammation	1.21781193
67	MP0010234_abnormal_vibrissa_follicle	1.15333591
68	MP0003959_abnormal_lean_body	1.13784102
69	MP0001348_abnormal_lacrimal_gland	1.13653052
70	MP0003656_abnormal_erythrocyte_physiolo	1.12730992
71	MP0003453_abnormal_keratinocyte_physiol	1.12396258
72	MP0005023_abnormal_wound_healing	1.11311645
73	MP0004858_abnormal_nervous_system	1.11205687
74	MP0002933_joint_inflammation	1.11100727
75	MP0001915_intracranial_hemorrhage	1.10708856
76	MP0004947_skin_inflammation	1.09378024
77	MP0009333_abnormal_splenocyte_physiolog	1.08803387
78	MP0003724_increased_susceptibility_to	1.08378513
79	MP0002876_abnormal_thyroid_physiology	1.07235322
80	MP0005220_abnormal_exocrine_pancreas	1.06690348
81	MP0003186_abnormal_redox_activity	1.06106356
82	MP0001958_emphysema	1.05875868
83	MP0002090_abnormal_vision	1.01210307
84	MP0005647_abnormal_sex_gland	1.00172036
85	MP0010155_abnormal_intestine_physiology	1.00000901
86	MP0000678_abnormal_parathyroid_gland	0.95886162
87	MP0003763_abnormal_thymus_physiology	0.95096644
88	MP0009780_abnormal_chondrocyte_physiolo	0.94867916
89	MP0001756_abnormal_urination	0.94493620
90	MP0001533_abnormal_skeleton_physiology	0.93652394
91	MP0000598_abnormal_liver_morphology	0.93312415
92	MP0000566_synostosis	0.89705243
93	MP0001851_eye_inflammation	0.88916786
94	MP0003329_amyloid_beta_deposits	0.88202704
95	MP0000604_amyloidosis	0.87616978
96	MP0005025_abnormal_response_to	0.87499442
97	MP0004043_abnormal_pH_regulation	0.87174167
98	MP0001881_abnormal_mammary_gland	0.86532875
99	MP0003953_abnormal_hormone_level	0.85287785
100	MP0000249_abnormal_blood_vessel	0.84726654
101	MP0001944_abnormal_pancreas_morphology	0.84382978
102	MP0010368_abnormal_lymphatic_system	0.82458854
103	MP0005387_immune_system_phenotype	0.81302028
104	MP0001790_abnormal_immune_system	0.81302028
105	MP0005408_hypopigmentation	0.81292728
106	MP0009642_abnormal_blood_homeostasis	0.78536427
107	MP0008469_abnormal_protein_level	0.77034378
108	MP0000767_abnormal_smooth_muscle	0.76640937
109	MP0004782_abnormal_surfactant_physiolog	0.76233051
110	MP0005636_abnormal_mineral_homeostasis	0.76187744
111	MP0005330_cardiomyopathy	0.74011156
112	MP0002254_reproductive_system_inflammat	0.73288132
113	MP0002998_abnormal_bone_remodeling	0.72951166
114	MP0002060_abnormal_skin_morphology	0.72892173
115	MP0000230_abnormal_systemic_arterial	0.72800222
116	MP0005164_abnormal_response_to	0.72798408
117	MP0003879_abnormal_hair_cell	0.71447598
118	MP0005452_abnormal_adipose_tissue	0.71289543
119	MP0002796_impaired_skin_barrier	0.70874047
120	MP0003300_gastrointestinal_ulcer	0.70566556
121	MP0002249_abnormal_larynx_morphology	0.70147519
122	MP0001800_abnormal_humoral_immune	0.68829326
123	MP0002419_abnormal_innate_immunity	0.68577523
124	MP0005058_abnormal_lysosome_morphology	0.66759160
125	MP0008775_abnormal_heart_ventricle	0.66460269
126	MP0009763_increased_sensitivity_to	0.66428166
127	MP0003690_abnormal_glial_cell	0.65362169
128	MP0005551_abnormal_eye_electrophysiolog	0.65289430
129	MP0006138_congestive_heart_failure	0.64658258
130	MP0009384_cardiac_valve_regurgitation	0.63173258
131	MP0005084_abnormal_gallbladder_morpholo	0.62650281
132	MP0004147_increased_porphyrin_level	0.61298738
133	MP0002269_muscular_atrophy	0.60629731
134	MP0004272_abnormal_basement_membrane	0.60262744
135	MP0004087_abnormal_muscle_fiber	0.58516042
136	MP0006035_abnormal_mitochondrial_morpho	0.58371942
137	MP0005248_abnormal_Harderian_gland	0.57183806
138	MP0004036_abnormal_muscle_relaxation	0.56195573
139	MP0003221_abnormal_cardiomyocyte_apopto	0.54798349
140	MP0005376_homeostasis/metabolism_phenot	0.54335997
141	MP0004084_abnormal_cardiac_muscle	0.52876079
142	MP0009765_abnormal_xenobiotic_induced	0.51556025
143	MP0002877_abnormal_melanocyte_morpholog	0.50036445
144	MP0009764_decreased_sensitivity_to	0.49899012
145	MP0005620_abnormal_muscle_contractility	0.49662890
146	MP0000751_myopathy	0.49228108
147	MP0002168_other_aberrant_phenotype	0.48874433
148	MP0005595_abnormal_vascular_smooth	0.48819485
149	MP0005266_abnormal_metabolism	0.48096975
150	MP0000639_abnormal_adrenal_gland	0.47900093

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	5.07419233
2	Hyperglycinuria (HP:0003108)	5.03722702
3	Deep venous thrombosis (HP:0002625)	4.95081832
4	Xanthomatosis (HP:0000991)	4.93133886
5	Hypoglycemic coma (HP:0001325)	4.69147877
6	Ketosis (HP:0001946)	4.46381503
7	Abnormality of glycine metabolism (HP:0010895)	4.44693022
8	Abnormality of serine family amino acid metabolism (HP:0010894)	4.44693022
9	Hyperlipoproteinemia (HP:0010980)	4.40416579
10	Hyperglycinemia (HP:0002154)	4.34716122
11	Complement deficiency (HP:0004431)	4.21553425
12	Intrahepatic cholestasis (HP:0001406)	4.19601887
13	Hyperammonemia (HP:0001987)	4.08851802
14	Ketoacidosis (HP:0001993)	4.00760501
15	Abnormality of fatty-acid metabolism (HP:0004359)	3.99939236
16	Systemic lupus erythematosus (HP:0002725)	3.90487476
17	Hypoalphalipoproteinemia (HP:0003233)	3.87628980
18	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.83468095
19	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.79020896
20	Epidermoid cyst (HP:0200040)	3.70079295
21	Hypobetalipoproteinemia (HP:0003563)	3.66418194
22	Hypolipoproteinemia (HP:0010981)	3.57443792
23	Prolonged partial thromboplastin time (HP:0003645)	3.53228811
24	Glomerulonephritis (HP:0000099)	3.46256067
25	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.39034122
26	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.23684826
27	Myoglobinuria (HP:0002913)	3.23130521
28	Oligomenorrhea (HP:0000876)	3.20006309
29	Abnormality of the common coagulation pathway (HP:0010990)	3.11169230
30	Menorrhagia (HP:0000132)	3.04249731
31	Abnormality of the intrinsic pathway (HP:0010989)	3.04230577
32	Dicarboxylic aciduria (HP:0003215)	3.01591883
33	Abnormality of dicarboxylic acid metabolism (HP:0010995)	3.01591883
34	Abnormality of complement system (HP:0005339)	2.90565281
35	Abnormality of proline metabolism (HP:0010907)	2.84565690
36	Hydroxyprolinuria (HP:0003080)	2.84565690
37	Flat acetabular roof (HP:0003180)	2.83287166
38	Purpura (HP:0000979)	2.82349105
39	Hypercholesterolemia (HP:0003124)	2.82239712
40	Hypertriglyceridemia (HP:0002155)	2.80688608
41	Skin nodule (HP:0200036)	2.79785731
42	Nephritis (HP:0000123)	2.70220000
43	Hypoglycemic seizures (HP:0002173)	2.69277438
44	Gingival bleeding (HP:0000225)	2.64895729
45	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.59560628
46	Recurrent gram-negative bacterial infections (HP:0005420)	2.58735885
47	Acanthosis nigricans (HP:0000956)	2.58081500
48	Abnormality of serum amino acid levels (HP:0003112)	2.55513592
49	Fat malabsorption (HP:0002630)	2.53377187
50	Generalized aminoaciduria (HP:0002909)	2.51986917
51	Abnormality of purine metabolism (HP:0004352)	2.48636606
52	Hyperbilirubinemia (HP:0002904)	2.45572426
53	Eczematoid dermatitis (HP:0000976)	2.44096365
54	Metabolic acidosis (HP:0001942)	2.43511426
55	Late onset (HP:0003584)	2.41633280
56	Myocardial infarction (HP:0001658)	2.38931643
57	Hyperglycemia (HP:0003074)	2.37323241
58	Abnormality of carpal bone ossification (HP:0006257)	2.35095998
59	Mitral stenosis (HP:0001718)	2.33789280
60	Brushfield spots (HP:0001088)	2.33614461
61	Hyperinsulinemic hypoglycemia (HP:0000825)	2.33272401
62	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.32645148
63	Abnormal tarsal ossification (HP:0008369)	2.29853871
64	Rhabdomyolysis (HP:0003201)	2.29029102
65	Pigmentary retinal degeneration (HP:0001146)	2.27157382
66	Insulin-resistant diabetes mellitus (HP:0000831)	2.25205086
67	Vertebral compression fractures (HP:0002953)	2.25189527
68	Joint hemorrhage (HP:0005261)	2.24590019
69	Pancreatitis (HP:0001733)	2.22757710
70	Cholelithiasis (HP:0001081)	2.22119881
71	Insulin resistance (HP:0000855)	2.21423277
72	Abnormal cartilage morphology (HP:0002763)	2.21228433
73	Lethargy (HP:0001254)	2.19418084
74	Abnormal gallbladder morphology (HP:0012437)	2.18948498
75	Cerebral aneurysm (HP:0004944)	2.15652000
76	Gout (HP:0001997)	2.14960866
77	Vascular calcification (HP:0004934)	2.14268531
78	Hepatocellular carcinoma (HP:0001402)	2.11945558
79	Cholecystitis (HP:0001082)	2.10969019
80	Abnormal gallbladder physiology (HP:0012438)	2.10969019
81	Conjugated hyperbilirubinemia (HP:0002908)	2.07939887
82	Abnormal ossification of hand bones (HP:0005921)	2.07374013
83	Gastrointestinal infarctions (HP:0005244)	2.05279047
84	Arterial tortuosity (HP:0005116)	2.03385853
85	Cardiovascular calcification (HP:0011915)	2.03323605
86	Sensorimotor neuropathy (HP:0007141)	2.03262058
87	Abnormal platelet volume (HP:0011876)	2.03133736
88	Hemorrhage of the eye (HP:0011885)	2.02442839
89	Delayed CNS myelination (HP:0002188)	2.02146373
90	Prolonged bleeding time (HP:0003010)	1.99578955
91	Epistaxis (HP:0000421)	1.99012091
92	Abnormality of nucleobase metabolism (HP:0010932)	1.98666615
93	Back pain (HP:0003418)	1.98465745
94	Rickets (HP:0002748)	1.97575132
95	Polygenic inheritance (HP:0010982)	1.96638449
96	Vascular tortuosity (HP:0004948)	1.96261844
97	Increased mean platelet volume (HP:0011877)	1.95966560
98	Cupped ribs (HP:0000887)	1.95406818
99	Palpitations (HP:0001962)	1.95072789
100	Vomiting (HP:0002013)	1.93805285
101	Neonatal onset (HP:0003623)	1.93199956
102	Aneurysm (HP:0002617)	1.91211428
103	Small epiphyses (HP:0010585)	1.91110369
104	Growth hormone excess (HP:0000845)	1.90590620
105	Asymmetry of the thorax (HP:0001555)	1.89488214
106	Irritability (HP:0000737)	1.89386979
107	Nausea (HP:0002018)	1.89227138
108	Peritonitis (HP:0002586)	1.87662553
109	Abnormality of methionine metabolism (HP:0010901)	1.87636889
110	Subcapsular cataract (HP:0000523)	1.87025479
111	Coxa vara (HP:0002812)	1.86995664
112	Poikilocytosis (HP:0004447)	1.86062679
113	Malnutrition (HP:0004395)	1.85039764
114	Limb hypertonia (HP:0002509)	1.84815972
115	Cerebral edema (HP:0002181)	1.84527345
116	Polycythemia (HP:0001901)	1.84508997
117	Increased muscle lipid content (HP:0009058)	1.84408965
118	Amyloidosis (HP:0011034)	1.83801466
119	Thin bony cortex (HP:0002753)	1.83446279
120	Premature rupture of membranes (HP:0001788)	1.83103352
121	Emphysema (HP:0002097)	1.81363177
122	Protrusio acetabuli (HP:0003179)	1.81254614
123	Acanthocytosis (HP:0001927)	1.80615553
124	Turricephaly (HP:0000262)	1.79986631
125	Right ventricular cardiomyopathy (HP:0011663)	1.78856388
126	Central scotoma (HP:0000603)	1.77939953
127	Achilles tendon contracture (HP:0001771)	1.77722640
128	Colitis (HP:0002583)	1.77680206
129	Steatorrhea (HP:0002570)	1.77446871
130	Tetraparesis (HP:0002273)	1.77315317
131	Abnormality of the gallbladder (HP:0005264)	1.75905484
132	Exercise-induced myalgia (HP:0003738)	1.75145027
133	Spastic diplegia (HP:0001264)	1.73693391
134	Spontaneous abortion (HP:0005268)	1.72850890
135	Long toe (HP:0010511)	1.72648595
136	Abnormal hand bone ossification (HP:0010660)	1.71798429
137	Abnormality of the Achilles tendon (HP:0005109)	1.71644046
138	Stroke (HP:0001297)	1.71166182
139	Cellulitis (HP:0100658)	1.71055302
140	Gastrointestinal stroma tumor (HP:0100723)	1.70940506
141	Abnormal foot bone ossification (HP:0010675)	1.70611912
142	Gingivitis (HP:0000230)	1.70217956
143	Hypophosphatemia (HP:0002148)	1.68140908
144	Thrombophlebitis (HP:0004418)	1.67312643
145	Blue sclerae (HP:0000592)	1.66644649
146	Metaphyseal cupping (HP:0003021)	1.66214712
147	Pulmonary embolism (HP:0002204)	1.65320436
148	Elevated alkaline phosphatase (HP:0003155)	1.64955647
149	Biconcave vertebral bodies (HP:0004586)	1.64099938
150	Hypochromic anemia (HP:0001931)	1.63914398
151	Dilatation of the ascending aorta (HP:0005111)	1.60568832
152	Mucopolysacchariduria (HP:0008155)	1.60537515
153	Urinary glycosaminoglycan excretion (HP:0003541)	1.60537515
154	Osteomalacia (HP:0002749)	1.60424710
155	Aortic aneurysm (HP:0004942)	1.59927710
156	Cerebral inclusion bodies (HP:0100314)	1.58324286
157	Abnormal enzyme/coenzyme activity (HP:0012379)	1.55719826
158	Abnormality of the peritoneum (HP:0002585)	1.55228241
159	Abnormality of the acetabulum (HP:0003170)	1.55123005
160	Increased IgE level (HP:0003212)	1.54854883
161	Abnormality of alkaline phosphatase activity (HP:0004379)	1.54600616
162	Osteoarthritis (HP:0002758)	1.54531620
163	Increased variability in muscle fiber diameter (HP:0003557)	1.54031750
164	Bronchomalacia (HP:0002780)	1.53570895
165	Abnormality of the lumbar spine (HP:0100712)	1.52617280

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	5.41682018
2	TRIB3	5.34157771
3	ERN1	4.08373245
4	SIK1	4.02377937
5	PRPF4B	3.18166470
6	CAMK1D	2.80973207
7	CDK12	2.73893144
8	PKN2	2.73687879
9	SMG1	2.34474418
10	RIPK1	2.33485826
11	INSRR	2.14316951
12	FGFR4	2.06677553
13	PDK4	2.05991321
14	PDK3	2.05991321
15	CAMK1G	1.99703988
16	LATS1	1.84147896
17	RIPK4	1.57907676
18	MAP3K13	1.55624722
19	TAOK3	1.50981924
20	LMTK2	1.50941714
21	PDGFRA	1.50269235
22	ICK	1.47116181
23	MAP4K1	1.46861801
24	EPHA2	1.46374272
25	PTK6	1.44666643
26	FRK	1.43079070
27	EEF2K	1.42231221
28	MATK	1.36383011
29	PHKG1	1.28276276
30	PHKG2	1.28276276
31	PINK1	1.24091404
32	FLT3	1.22863092
33	TESK1	1.17455624
34	DAPK2	1.16954043
35	MST1R	1.16281390
36	PRKAA2	1.14594197
37	CDC42BPA	1.12181675
38	MAPKAPK3	1.11442567
39	PIK3CG	1.10408159
40	PRKD3	1.10214086
41	ZAP70	1.08510583
42	PDK2	1.07449729
43	EPHA3	1.07282132
44	GRK6	1.00943410
45	MAP3K7	0.97279170
46	ARAF	0.96945345
47	PRKAA1	0.95977872
48	MAP2K1	0.93846605
49	DDR2	0.93816232
50	DYRK1B	0.92998486
51	MAPK11	0.92760956
52	RET	0.91275888
53	SIK2	0.89771870
54	KSR2	0.86323570
55	LATS2	0.84430348
56	TAOK2	0.84073896
57	PAK3	0.83291119
58	MAP3K11	0.82479753
59	MAP2K4	0.81960394
60	FER	0.81372851
61	MAP3K10	0.80828810
62	MTOR	0.80434208
63	JAK2	0.78631416
64	MAP3K2	0.75291619
65	EPHB2	0.74364081
66	TGFBR2	0.73890991
67	IRAK3	0.71445964
68	CSK	0.70967865
69	JAK1	0.70332992
70	PDPK1	0.66695388
71	MAP3K6	0.65806518
72	MAP3K14	0.65683394
73	TTN	0.64898072
74	MAPK15	0.63878741
75	PTK2	0.63482700
76	TAOK1	0.63073626
77	JAK3	0.63071943
78	CDK9	0.62567282
79	CDK6	0.61101495
80	PRKD2	0.60525840
81	CAMKK1	0.60177983
82	BMX	0.59620572
83	MAP2K2	0.59478636
84	PRKACG	0.59227326
85	CDK4	0.58727359
86	CDK7	0.57879713
87	HIPK2	0.57761119
88	FGFR2	0.57120300
89	TIE1	0.56934631
90	NEK1	0.56262880
91	STK38	0.55371122
92	PRKCH	0.55204657
93	NTRK1	0.54742704
94	MAP3K1	0.54202604
95	SIK3	0.53696261
96	PRKCZ	0.52336661
97	PRKD1	0.51966282
98	STK38L	0.51855108
99	PRKG2	0.51831274
100	IRAK1	0.51383602
101	PAK2	0.51299762
102	FGFR3	0.51219931
103	MAP3K9	0.51110650
104	IRAK4	0.50458896
105	PAK6	0.47336366
106	CSF1R	0.46922228
107	BTK	0.45788945
108	MAPK12	0.45292328
109	MAP3K3	0.45036047
110	PDK1	0.44801511
111	MET	0.44358929
112	HCK	0.44141474
113	PAK4	0.43977705
114	RPS6KC1	0.43828814
115	RPS6KL1	0.43828814
116	CAMKK2	0.43566875
117	BLK	0.43228943
118	NEK9	0.41226990
119	TNK2	0.40908724
120	MAP3K8	0.40024366
121	WNK1	0.39941736
122	IKBKE	0.38893376
123	YES1	0.38889258
124	LRRK2	0.38340978
125	ERBB2	0.37769152
126	IRAK2	0.37613591
127	FGR	0.37227833
128	TYK2	0.37167455
129	BRAF	0.36479336
130	MYLK	0.36337626
131	NLK	0.35839323
132	GSK3A	0.35789372
133	CAMK2G	0.35744125
134	TYRO3	0.35464714
135	SGK3	0.35322987
136	AKT3	0.34912659
137	MAP2K3	0.34500585
138	MARK2	0.32800178
139	PDGFRB	0.31557169
140	EPHB1	0.31132276
141	RPS6KA2	0.30942261
142	ILK	0.30564266
143	DAPK3	0.29150044
144	CSNK1G1	0.29018891
145	TBK1	0.28758592

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.22293606
2	Fatty acid degradation_Homo sapiens_hsa00071	3.18739790
3	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	3.10222556
4	Propanoate metabolism_Homo sapiens_hsa00640	3.09368219
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.94883180
6	PPAR signaling pathway_Homo sapiens_hsa03320	2.83711499
7	Fatty acid metabolism_Homo sapiens_hsa01212	2.70629805
8	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.62492673
9	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.40004558
10	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.37415762
11	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.31411447
12	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.28884573
13	Arginine biosynthesis_Homo sapiens_hsa00220	2.22124344
14	Tryptophan metabolism_Homo sapiens_hsa00380	2.18902946
15	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.17726709
16	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.04497627
17	Butanoate metabolism_Homo sapiens_hsa00650	2.02041242
18	Pyruvate metabolism_Homo sapiens_hsa00620	1.94684408
19	Peroxisome_Homo sapiens_hsa04146	1.83672355
20	Complement and coagulation cascades_Homo sapiens_hsa04610	1.83085843
21	Caffeine metabolism_Homo sapiens_hsa00232	1.82923003
22	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.79980035
23	beta-Alanine metabolism_Homo sapiens_hsa00410	1.73007195
24	Other glycan degradation_Homo sapiens_hsa00511	1.69611062
25	Fat digestion and absorption_Homo sapiens_hsa04975	1.66721062
26	Carbon metabolism_Homo sapiens_hsa01200	1.64706393
27	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.49028560
28	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.41497568
29	Glycerolipid metabolism_Homo sapiens_hsa00561	1.40033803
30	Bile secretion_Homo sapiens_hsa04976	1.37807335
31	Fatty acid elongation_Homo sapiens_hsa00062	1.31271402
32	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.30522210
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.29354084
34	Sulfur metabolism_Homo sapiens_hsa00920	1.27118376
35	Non-small cell lung cancer_Homo sapiens_hsa05223	1.26853831
36	Acute myeloid leukemia_Homo sapiens_hsa05221	1.23312194
37	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.21485161
38	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.20453347
39	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.19793183
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.17946395
41	Selenocompound metabolism_Homo sapiens_hsa00450	1.17880322
42	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.16675083
43	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.15609745
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.14442588
45	ABC transporters_Homo sapiens_hsa02010	1.14358245
46	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.12630159
47	Phenylalanine metabolism_Homo sapiens_hsa00360	1.10670859
48	Retinol metabolism_Homo sapiens_hsa00830	1.09447052
49	Histidine metabolism_Homo sapiens_hsa00340	1.08607705
50	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.04089757
51	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.03964799
52	Pancreatic cancer_Homo sapiens_hsa05212	1.03684931
53	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.00153532
54	Tyrosine metabolism_Homo sapiens_hsa00350	0.99761824
55	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.99110927
56	Folate biosynthesis_Homo sapiens_hsa00790	0.99086424
57	Endometrial cancer_Homo sapiens_hsa05213	0.96878728
58	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.96166401
59	Sulfur relay system_Homo sapiens_hsa04122	0.95864915
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.95060732
61	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.91822977
62	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.86869497
63	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.86515343
64	Insulin resistance_Homo sapiens_hsa04931	0.86198429
65	AMPK signaling pathway_Homo sapiens_hsa04152	0.85491241
66	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.82752190
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.79957766
68	Thyroid cancer_Homo sapiens_hsa05216	0.79072855
69	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.78811988
70	Lysine degradation_Homo sapiens_hsa00310	0.76798909
71	VEGF signaling pathway_Homo sapiens_hsa04370	0.72615146
72	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.72020510
73	Notch signaling pathway_Homo sapiens_hsa04330	0.71594328
74	Hepatitis C_Homo sapiens_hsa05160	0.69397138
75	Renal cell carcinoma_Homo sapiens_hsa05211	0.68814899
76	Glucagon signaling pathway_Homo sapiens_hsa04922	0.68301057
77	Pentose phosphate pathway_Homo sapiens_hsa00030	0.66590402
78	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.65558326
79	Bladder cancer_Homo sapiens_hsa05219	0.64018492
80	Renin-angiotensin system_Homo sapiens_hsa04614	0.63777896
81	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.63417933
82	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.62068205
83	Insulin signaling pathway_Homo sapiens_hsa04910	0.61696206
84	Focal adhesion_Homo sapiens_hsa04510	0.60267604
85	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.58476973
86	Prostate cancer_Homo sapiens_hsa05215	0.57237303
87	Prolactin signaling pathway_Homo sapiens_hsa04917	0.56831797
88	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.56123168
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.54262875
90	Osteoclast differentiation_Homo sapiens_hsa04380	0.53074693
91	Galactose metabolism_Homo sapiens_hsa00052	0.52897988
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.50904414
93	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.50768058
94	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.50244665
95	Pertussis_Homo sapiens_hsa05133	0.50200271
96	Toxoplasmosis_Homo sapiens_hsa05145	0.48846142
97	Amoebiasis_Homo sapiens_hsa05146	0.48712081
98	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.48077760
99	Adherens junction_Homo sapiens_hsa04520	0.47797744
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47557606
101	ECM-receptor interaction_Homo sapiens_hsa04512	0.47091953
102	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.47020383
103	Choline metabolism in cancer_Homo sapiens_hsa05231	0.46591228
104	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.46158894
105	Leishmaniasis_Homo sapiens_hsa05140	0.45867990
106	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.44607804
107	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.44402783
108	Influenza A_Homo sapiens_hsa05164	0.44009810
109	Proteoglycans in cancer_Homo sapiens_hsa05205	0.43701780
110	ErbB signaling pathway_Homo sapiens_hsa04012	0.42340529
111	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.41765783
112	Small cell lung cancer_Homo sapiens_hsa05222	0.41080542
113	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.40986071
114	Protein digestion and absorption_Homo sapiens_hsa04974	0.39894471
115	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.39194896
116	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.36921170
117	Metabolic pathways_Homo sapiens_hsa01100	0.36730439
118	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.36499350
119	Olfactory transduction_Homo sapiens_hsa04740	0.34041521
120	Prion diseases_Homo sapiens_hsa05020	0.33747553
121	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.32563563
122	Glutathione metabolism_Homo sapiens_hsa00480	0.28068638
123	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.26635173
124	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.25052286
125	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.23829993
126	Type II diabetes mellitus_Homo sapiens_hsa04930	0.22160004
127	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.21581020
128	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.20739319
129	Circadian rhythm_Homo sapiens_hsa04710	0.15771911
130	Insulin secretion_Homo sapiens_hsa04911	0.15583410
131	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.15358159
132	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.15182180
133	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.15129307
134	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.14864417
135	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.14585524
136	mTOR signaling pathway_Homo sapiens_hsa04150	0.12368152
137	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.10843446
138	Renin secretion_Homo sapiens_hsa04924	0.08876710
139	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.08601960
140	Linoleic acid metabolism_Homo sapiens_hsa00591	0.06081098
141	Lysosome_Homo sapiens_hsa04142	0.05957424

ORMDL3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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