OS9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.13096233
2L-phenylalanine catabolic process (GO:0006559)5.13096233
3L-phenylalanine metabolic process (GO:0006558)4.93328678
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.93328678
5aromatic amino acid family catabolic process (GO:0009074)4.33787179
6sulfur amino acid catabolic process (GO:0000098)4.28727932
7alpha-linolenic acid metabolic process (GO:0036109)4.28652234
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.23698378
9complement activation, alternative pathway (GO:0006957)4.13898443
10protein carboxylation (GO:0018214)4.12395774
11peptidyl-glutamic acid carboxylation (GO:0017187)4.12395774
12cysteine metabolic process (GO:0006534)4.01261859
13barbed-end actin filament capping (GO:0051016)3.89814147
14high-density lipoprotein particle remodeling (GO:0034375)3.85596187
15urea cycle (GO:0000050)3.85466789
16urea metabolic process (GO:0019627)3.85466789
17intestinal cholesterol absorption (GO:0030299)3.82184770
18bile acid biosynthetic process (GO:0006699)3.81123743
19kynurenine metabolic process (GO:0070189)3.77432341
20regulation of cholesterol homeostasis (GO:2000188)3.75786060
21regulation of protein activation cascade (GO:2000257)3.74942853
22negative regulation of fibrinolysis (GO:0051918)3.74134017
23glyoxylate metabolic process (GO:0046487)3.72820993
24protein localization to endosome (GO:0036010)3.70151107
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.69371937
26tryptophan catabolic process (GO:0006569)3.67813778
27indole-containing compound catabolic process (GO:0042436)3.67813778
28indolalkylamine catabolic process (GO:0046218)3.67813778
29reverse cholesterol transport (GO:0043691)3.65006047
30Golgi transport vesicle coating (GO:0048200)3.63600990
31COPI coating of Golgi vesicle (GO:0048205)3.63600990
32negative regulation of sterol transport (GO:0032372)3.62700411
33negative regulation of cholesterol transport (GO:0032375)3.62700411
34lysine catabolic process (GO:0006554)3.61040021
35lysine metabolic process (GO:0006553)3.61040021
36regulation of complement activation (GO:0030449)3.59069462
37cellular modified amino acid catabolic process (GO:0042219)3.56848118
38tryptophan metabolic process (GO:0006568)3.55905304
39nitrogen cycle metabolic process (GO:0071941)3.49353974
40homocysteine metabolic process (GO:0050667)3.46606015
41regulation of triglyceride catabolic process (GO:0010896)3.45092974
42regulation of fibrinolysis (GO:0051917)3.42007564
43phospholipid efflux (GO:0033700)3.41017661
44bile acid metabolic process (GO:0008206)3.38710275
45plasma lipoprotein particle remodeling (GO:0034369)3.31247522
46protein-lipid complex remodeling (GO:0034368)3.31247522
47macromolecular complex remodeling (GO:0034367)3.31247522
48plasma lipoprotein particle clearance (GO:0034381)3.27605758
49valine metabolic process (GO:0006573)3.25481351
50skin morphogenesis (GO:0043589)3.19679870
51cholesterol efflux (GO:0033344)3.17999272
52acylglycerol homeostasis (GO:0055090)3.11872645
53triglyceride homeostasis (GO:0070328)3.11872645
54negative regulation of erythrocyte differentiation (GO:0045647)3.11866124
55glycosphingolipid catabolic process (GO:0046479)3.11187838
56regulation of cholesterol esterification (GO:0010872)3.10708344
57pinocytosis (GO:0006907)3.10334479
58tyrosine metabolic process (GO:0006570)3.09612638
59cellular ketone body metabolic process (GO:0046950)3.09587746
60aromatic amino acid family metabolic process (GO:0009072)3.09565438
61response to peptidoglycan (GO:0032494)3.09024702
62glutamate metabolic process (GO:0006536)3.07796794
63bile acid and bile salt transport (GO:0015721)3.07357640
64ethanol oxidation (GO:0006069)3.03988605
65amino-acid betaine metabolic process (GO:0006577)3.03585776
66antigen processing and presentation of endogenous antigen (GO:0019883)3.02863186
67serine family amino acid catabolic process (GO:0009071)2.97465363
68alpha-amino acid catabolic process (GO:1901606)2.97191623
69plasma lipoprotein particle assembly (GO:0034377)2.96532690
70phospholipid homeostasis (GO:0055091)2.96164899
71positive regulation of fatty acid beta-oxidation (GO:0032000)2.96124445
72drug catabolic process (GO:0042737)2.95895564
73drug transmembrane transport (GO:0006855)2.92923059
74regulation of fatty acid beta-oxidation (GO:0031998)2.91974808
75cellular amino acid catabolic process (GO:0009063)2.90750039
76coenzyme catabolic process (GO:0009109)2.90451067
77* maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.89632423
784-hydroxyproline metabolic process (GO:0019471)2.89100183
79protein-lipid complex assembly (GO:0065005)2.88907291
80positive regulation of lipid catabolic process (GO:0050996)2.88788748
81regulation of extracellular matrix disassembly (GO:0010715)2.86704091
82antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.86097855
83antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.86097855
84short-chain fatty acid metabolic process (GO:0046459)2.85961768
852-oxoglutarate metabolic process (GO:0006103)2.85498448
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.85264170
87complement activation, classical pathway (GO:0006958)2.84581161
88complement activation (GO:0006956)2.84423003
89positive regulation of fatty acid biosynthetic process (GO:0045723)2.82553553
90regulation of cholesterol biosynthetic process (GO:0045540)2.82335964
91glycolipid catabolic process (GO:0019377)2.80533881
92peptide catabolic process (GO:0043171)2.79249004
93positive regulation of triglyceride metabolic process (GO:0090208)2.78985948
94lipoprotein metabolic process (GO:0042157)2.78614850
95activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.76600014
96positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.76263792
97cholesterol homeostasis (GO:0042632)2.76218616
98dicarboxylic acid biosynthetic process (GO:0043650)2.76215107
99positive regulation of lipoprotein lipase activity (GO:0051006)2.75994017
100positive regulation of triglyceride lipase activity (GO:0061365)2.75994017
101retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.75111023
102sterol homeostasis (GO:0055092)2.74951733
103transcytosis (GO:0045056)2.74425180
104apoptotic cell clearance (GO:0043277)2.73981632
105plasma lipoprotein particle organization (GO:0071827)2.72282365
106intestinal absorption (GO:0050892)2.71936511
107detection of other organism (GO:0098543)2.71589186
108indolalkylamine metabolic process (GO:0006586)2.70364197
109benzene-containing compound metabolic process (GO:0042537)2.70052337
110protein-lipid complex subunit organization (GO:0071825)2.69419251
111fibrinolysis (GO:0042730)2.67969589
112ketone body metabolic process (GO:1902224)2.66864351
113basement membrane organization (GO:0071711)2.66351145
114cytolysis (GO:0019835)2.66224998
115fatty acid oxidation (GO:0019395)2.65484098
116detection of molecule of bacterial origin (GO:0032490)2.65038008
117regulation of leukocyte degranulation (GO:0043300)2.63570601
118positive regulation by symbiont of host defense response (GO:0052509)2.63168998
119modulation by symbiont of host defense response (GO:0052031)2.63168998
120modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.63168998
121modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.63168998
122positive regulation by organism of defense response of other organism involved in symbiotic interact2.63168998
123modulation by symbiont of host immune response (GO:0052553)2.63168998
124mannose metabolic process (GO:0006013)2.63053879
125* protein retention in ER lumen (GO:0006621)2.62135850
126acute-phase response (GO:0006953)2.62069475
127cholesterol transport (GO:0030301)2.61761588
128response to laminar fluid shear stress (GO:0034616)2.60759110
129detection of bacterium (GO:0016045)2.60042379
130macrophage activation involved in immune response (GO:0002281)2.60011754
131negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.59870418
132negative regulation of cell killing (GO:0031342)2.59870418
133positive regulation of extracellular matrix organization (GO:1903055)2.58728846
134detection of external biotic stimulus (GO:0098581)2.58038263
135positive regulation of Cdc42 GTPase activity (GO:0043089)2.56492240
136response to muramyl dipeptide (GO:0032495)2.55015084
137stress fiber assembly (GO:0043149)2.54731848
138adhesion of symbiont to host (GO:0044406)2.54453975
139lipopolysaccharide-mediated signaling pathway (GO:0031663)2.52258847
140low-density lipoprotein particle clearance (GO:0034383)2.49141228
141cellular response to thyroid hormone stimulus (GO:0097067)2.48567588
142positive regulation of cellular amide metabolic process (GO:0034250)2.48487327
143amyloid precursor protein catabolic process (GO:0042987)2.47455335
144oligosaccharide catabolic process (GO:0009313)2.44754750
145epithelial cell differentiation involved in prostate gland development (GO:0060742)2.43766019
146positive regulation of receptor recycling (GO:0001921)2.42624323
147response to thyroid hormone (GO:0097066)2.42400285
148regulation of myeloid leukocyte mediated immunity (GO:0002886)2.40046473
149surfactant homeostasis (GO:0043129)2.38999666
150positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.38034475
151adhesion of symbiont to host cell (GO:0044650)2.36534826
152virion attachment to host cell (GO:0019062)2.36534826
153positive regulation of gamma-delta T cell activation (GO:0046645)2.34510899
154hyaluronan catabolic process (GO:0030214)2.32783148
155cell adhesion mediated by integrin (GO:0033627)2.31953979
156fibril organization (GO:0097435)2.30967931
157positive regulation of leukocyte degranulation (GO:0043302)2.30797380
158regulation of early endosome to late endosome transport (GO:2000641)2.30721854
159positive regulation of phagocytosis (GO:0050766)2.30672625
160amino sugar catabolic process (GO:0046348)2.30608045
161positive regulation of nuclease activity (GO:0032075)2.30504087
162neutrophil activation involved in immune response (GO:0002283)2.29996486
163regulation of extracellular matrix organization (GO:1903053)2.29547223
164regulation of mast cell degranulation (GO:0043304)2.29272220
165ceramide catabolic process (GO:0046514)2.29030974
166detection of biotic stimulus (GO:0009595)2.24946277
167regulation of apoptotic cell clearance (GO:2000425)2.22962946
168keratan sulfate catabolic process (GO:0042340)2.21923297
169hypotonic response (GO:0006971)2.20576093
170endoplasmic reticulum unfolded protein response (GO:0030968)2.19260360
171membrane protein ectodomain proteolysis (GO:0006509)2.18681865
172negative regulation of interleukin-12 production (GO:0032695)2.18257544
173regulation of T-helper 2 cell differentiation (GO:0045628)2.18128280
174glial cell migration (GO:0008347)2.18064499
175cortical actin cytoskeleton organization (GO:0030866)2.17287168
176negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.16142058
177regulation of membrane protein ectodomain proteolysis (GO:0051043)2.14731637
178regulation of superoxide anion generation (GO:0032928)2.13388943
179negative regulation of type 2 immune response (GO:0002829)2.12155473
180glucose 6-phosphate metabolic process (GO:0051156)2.10350507
181embryo implantation (GO:0007566)2.10268753
182modulation by symbiont of host cellular process (GO:0044068)2.10054886
183endodermal cell differentiation (GO:0035987)2.10044948
184positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.08645643
185semaphorin-plexin signaling pathway (GO:0071526)2.07550865
186pentose-phosphate shunt (GO:0006098)2.06952345
187NIK/NF-kappaB signaling (GO:0038061)2.06705585
188cellular copper ion homeostasis (GO:0006878)2.06038490
189ER-nucleus signaling pathway (GO:0006984)2.06029433
190regulation of nuclease activity (GO:0032069)2.05659542
191regulation of cholesterol storage (GO:0010885)2.05272345
192angiotensin maturation (GO:0002003)2.04638850

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.13151426
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.24547372
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.61642572
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.27159362
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.53836320
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.26045035
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.97921037
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.78863616
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.44163238
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.42560074
11* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.33754817
12CLOCK_20551151_ChIP-Seq_293T_Human2.17555124
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96363295
14VDR_24763502_ChIP-Seq_THP-1_Human1.80818460
15IRF8_22096565_ChIP-ChIP_GC-B_Human1.77846101
16GATA1_22025678_ChIP-Seq_K562_Human1.73845771
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71701299
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66961353
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64627940
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.64382066
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63993193
22MYC_22102868_ChIP-Seq_BL_Human1.63117877
23RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.62726826
24LXR_22292898_ChIP-Seq_THP-1_Human1.61271285
25* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58125736
26* FOXA2_19822575_ChIP-Seq_HepG2_Human1.55728518
27* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.55704766
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52447718
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51678427
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.51462829
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.48162915
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.44693200
33SPI1_23127762_ChIP-Seq_K562_Human1.42522685
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42127018
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39410206
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39311434
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38141937
38MAF_26560356_Chip-Seq_TH1_Human1.34614937
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.33456702
40PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29371875
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.28954962
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28418325
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27089954
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26115749
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.25167107
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23517265
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23335430
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23097942
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23018715
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22537146
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.21128734
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20789615
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.19565692
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18142693
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.18079040
56UTX_26944678_Chip-Seq_JUKART_Human1.17720281
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17693207
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17423254
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16154179
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14874029
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14236331
62RACK7_27058665_Chip-Seq_MCF-7_Human1.13458236
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.13115814
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12542955
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12358012
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12134857
67GATA1_19941826_ChIP-Seq_K562_Human1.11608688
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11424780
69* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11158785
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10621680
71ATF3_27146783_Chip-Seq_COLON_Human1.09063589
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.07812468
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07617858
74MAF_26560356_Chip-Seq_TH2_Human1.06621496
75SMC4_20622854_ChIP-Seq_HELA_Human1.06416681
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.06085894
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05941296
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05934685
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05153564
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04980415
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.04741940
82TP53_22127205_ChIP-Seq_IMR90_Human1.04170449
83ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03706310
84STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03417169
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01828185
86AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01314481
87GATA4_25053715_ChIP-Seq_YYC3_Human1.00607972
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00420591
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00207628
90* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99401870
91HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99322802
92BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99010081
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98592058
94SOX2_20726797_ChIP-Seq_SW620_Human0.98344053
95CDX2_20551321_ChIP-Seq_CACO-2_Human0.98151575
96* SPI1_23547873_ChIP-Seq_NB4_Human0.97500532
97HNF4A_19822575_ChIP-Seq_HepG2_Human0.97482056
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97129194
99GATA2_19941826_ChIP-Seq_K562_Human0.96882809
100ELK3_25401928_ChIP-Seq_HUVEC_Human0.96828557
101KDM2B_26808549_Chip-Seq_DND41_Human0.95828099
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95605858
103TCF7_22412390_ChIP-Seq_EML_Mouse0.95095759
104KDM2B_26808549_Chip-Seq_K562_Human0.93795280
105DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93586246
106GATA1_19941827_ChIP-Seq_MEL_Mouse0.93078176
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92065692
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90424705
109PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90262954
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89315277
111RUNX_20019798_ChIP-Seq_JUKART_Human0.89131164
112P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87301191
113GATA6_25053715_ChIP-Seq_YYC3_Human0.87286454
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86935707
115ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86261888
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.85344751
117CREB1_26743006_Chip-Seq_LNCaP_Human0.84481937
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.83405485
119TBX20_22080862_ChIP-Seq_HEART_Mouse0.83405485
120ERG_21242973_ChIP-ChIP_JURKAT_Human0.83057645
121MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.82139018
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81164467
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81148294
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80104823
125EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.79869330
126MYB_21317192_ChIP-Seq_ERMYB_Mouse0.79759145
127ZNF263_19887448_ChIP-Seq_K562_Human0.79565428
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79349451
129RUNX1_27514584_Chip-Seq_MCF-7_Human0.79256216
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78824128
131FOXA1_25552417_ChIP-Seq_VCAP_Human0.77987906
132RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.77693729
133EGR1_19032775_ChIP-ChIP_M12_Human0.77466016
134EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77420754
135FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76652489
136VDR_21846776_ChIP-Seq_THP-1_Human0.75255011
137NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74573356
138NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74573356
139DROSHA_22980978_ChIP-Seq_HELA_Human0.73276445
140* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73106149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.87314343
2MP0005360_urolithiasis5.36006706
3MP0005365_abnormal_bile_salt4.73970864
4MP0005085_abnormal_gallbladder_physiolo4.29119001
5MP0008875_abnormal_xenobiotic_pharmacok3.64284277
6MP0003252_abnormal_bile_duct3.20118196
7MP0009840_abnormal_foam_cell3.01491993
8MP0001666_abnormal_nutrient_absorption2.99025559
9MP0005083_abnormal_biliary_tract2.96703303
10MP0010329_abnormal_lipoprotein_level2.87086989
11MP0003191_abnormal_cellular_cholesterol2.67391308
12MP0003195_calcinosis2.31805471
13MP0003300_gastrointestinal_ulcer2.27859938
14MP0005332_abnormal_amino_acid2.12335367
15MP0005058_abnormal_lysosome_morphology2.11136960
16MP0003705_abnormal_hypodermis_morpholog2.08235953
17MP0004858_abnormal_nervous_system1.99278913
18MP0002138_abnormal_hepatobiliary_system1.94299652
19MP0002118_abnormal_lipid_homeostasis1.88980203
20MP0000609_abnormal_liver_physiology1.84912022
21MP0000858_altered_metastatic_potential1.83586635
22MP0003868_abnormal_feces_composition1.82885867
23MP0005257_abnormal_intraocular_pressure1.81684946
24MP0010234_abnormal_vibrissa_follicle1.77091667
25MP0001958_emphysema1.74818349
26MP0008260_abnormal_autophagy1.74276689
27MP0002998_abnormal_bone_remodeling1.73020199
28MP0009643_abnormal_urine_homeostasis1.67313230
29MP0005220_abnormal_exocrine_pancreas1.64625508
30MP0005025_abnormal_response_to1.61918408
31MP0004019_abnormal_vitamin_homeostasis1.61576232
32MP0002909_abnormal_adrenal_gland1.61522437
33MP0003091_abnormal_cell_migration1.60810591
34MP0003279_aneurysm1.59224709
35MP0001835_abnormal_antigen_presentation1.57778375
36MP0000604_amyloidosis1.56511677
37MP0004272_abnormal_basement_membrane1.55917861
38MP0003806_abnormal_nucleotide_metabolis1.55906551
39MP0009785_altered_susceptibility_to1.53789782
40MP0001849_ear_inflammation1.49323661
41MP0005076_abnormal_cell_differentiation1.48711744
42MP0000343_altered_response_to1.45911523
43MP0005000_abnormal_immune_tolerance1.45084784
44MP0005319_abnormal_enzyme/_coenzyme1.44614145
45MP0009278_abnormal_bone_marrow1.43752333
46MP0003453_abnormal_keratinocyte_physiol1.43516921
47MP0002148_abnormal_hypersensitivity_rea1.41053097
48MP0005164_abnormal_response_to1.40661202
49MP0005409_darkened_coat_color1.38983980
50MP0003448_altered_tumor_morphology1.38875495
51MP0003172_abnormal_lysosome_physiology1.37953433
52MP0009780_abnormal_chondrocyte_physiolo1.37033565
53MP0005387_immune_system_phenotype1.29896391
54MP0005023_abnormal_wound_healing1.29621207
55MP0005584_abnormal_enzyme/coenzyme_acti1.29609646
56MP0003283_abnormal_digestive_organ1.28410089
57MP0008438_abnormal_cutaneous_collagen1.27559804
58MP0005275_abnormal_skin_tensile1.26779134
59MP0010155_abnormal_intestine_physiology1.26279352
60MP0003828_pulmonary_edema1.25727079
61MP0003183_abnormal_peptide_metabolism1.25589315
62MP0003329_amyloid_beta_deposits1.21685772
63MP0003303_peritoneal_inflammation1.20375298
64MP0008961_abnormal_basal_metabolism1.17594050
65MP0004510_myositis1.17285104
66MP0004043_abnormal_pH_regulation1.16606159
67MP0001756_abnormal_urination1.13915912
68MP0001944_abnormal_pancreas_morphology1.12098253
69MP0002078_abnormal_glucose_homeostasis1.12060223
70MP0001765_abnormal_ion_homeostasis1.11135639
71MP0005390_skeleton_phenotype1.10460400
72MP0001542_abnormal_bone_strength1.10439219
73MP0002452_abnormal_antigen_presenting1.09626580
74MP0003075_altered_response_to1.08881728
75MP0003656_abnormal_erythrocyte_physiolo1.07978715
76MP0002060_abnormal_skin_morphology1.07475003
77MP0004782_abnormal_surfactant_physiolog1.06912202
78MP0002723_abnormal_immune_serum1.05592270
79MP0002254_reproductive_system_inflammat1.05561637
80MP0002877_abnormal_melanocyte_morpholog1.05408752
81MP0003436_decreased_susceptibility_to1.05101733
82MP0005636_abnormal_mineral_homeostasis1.05021442
83MP0004130_abnormal_muscle_cell1.02200050
84MP0002693_abnormal_pancreas_physiology0.99638166
85MP0002166_altered_tumor_susceptibility0.99159638
86MP0002420_abnormal_adaptive_immunity0.98782058
87MP0001819_abnormal_immune_cell0.98706457
88MP0008469_abnormal_protein_level0.98511140
89MP0003795_abnormal_bone_structure0.97843568
90MP0000598_abnormal_liver_morphology0.97784489
91MP0005464_abnormal_platelet_physiology0.96944339
92MP0008004_abnormal_stomach_pH0.95428096
93MP0001545_abnormal_hematopoietic_system0.94670190
94MP0005397_hematopoietic_system_phenotyp0.94670190
95MP0005165_increased_susceptibility_to0.94339872
96MP0004947_skin_inflammation0.93290599
97MP0009764_decreased_sensitivity_to0.92601545
98MP0004883_abnormal_blood_vessel0.92355518
99MP0002405_respiratory_system_inflammati0.92057347
100MP0000767_abnormal_smooth_muscle0.91236702
101MP0000920_abnormal_myelination0.91080790
102MP0001851_eye_inflammation0.91030335
103MP0002928_abnormal_bile_duct0.89615114
104MP0000013_abnormal_adipose_tissue0.89614801
105MP0002933_joint_inflammation0.89134668
106MP0001853_heart_inflammation0.88822609
107MP0000681_abnormal_thyroid_gland0.88820154
108MP0009642_abnormal_blood_homeostasis0.88759873
109MP0003690_abnormal_glial_cell0.88662203
110MP0001800_abnormal_humoral_immune0.88076483
111MP0000678_abnormal_parathyroid_gland0.87788876
112MP0005167_abnormal_blood-brain_barrier0.87685426
113MP0009384_cardiac_valve_regurgitation0.86865923
114MP0005503_abnormal_tendon_morphology0.86467105
115MP0003045_fibrosis0.85952050
116MP0005670_abnormal_white_adipose0.84512082
117MP0002822_catalepsy0.84026883
118MP0004264_abnormal_extraembryonic_tissu0.83766172
119MP0009333_abnormal_splenocyte_physiolog0.83041988
120MP0002796_impaired_skin_barrier0.82923193
121MP0001915_intracranial_hemorrhage0.82421975
122MP0000465_gastrointestinal_hemorrhage0.82244787
123MP0003634_abnormal_glial_cell0.81818112
124MP0002136_abnormal_kidney_physiology0.81607697
125MP0001533_abnormal_skeleton_physiology0.80171425
126MP0004808_abnormal_hematopoietic_stem0.78971913
127MP0001764_abnormal_homeostasis0.78116811
128MP0000249_abnormal_blood_vessel0.77854789
129MP0009763_increased_sensitivity_to0.77568976
130MP0005334_abnormal_fat_pad0.77545702
131MP0005535_abnormal_body_temperature0.77430603
132MP0006082_CNS_inflammation0.76760241
133MP0005671_abnormal_response_to0.76661382
134MP0001845_abnormal_inflammatory_respons0.76449874
135MP0005310_abnormal_salivary_gland0.75937141
136MP0005448_abnormal_energy_balance0.74720514
137MP0002896_abnormal_bone_mineralization0.73599071
138MP0003724_increased_susceptibility_to0.71626234
139MP0003566_abnormal_cell_adhesion0.70830662
140MP0004185_abnormal_adipocyte_glucose0.70307133
141MP0002168_other_aberrant_phenotype0.70090330
142MP0000639_abnormal_adrenal_gland0.69611536
143MP0005166_decreased_susceptibility_to0.68978697
144MP0001873_stomach_inflammation0.68784787
145MP0003638_abnormal_response/metabolism_0.68319678
146MP0005666_abnormal_adipose_tissue0.68293782
147MP0005084_abnormal_gallbladder_morpholo0.67540917
148MP0000685_abnormal_immune_system0.67264450
149MP0003866_abnormal_defecation0.67115555
150MP0002971_abnormal_brown_adipose0.66819434
151MP0005451_abnormal_body_composition0.66260426
152MP0003959_abnormal_lean_body0.65487611
153MP0000003_abnormal_adipose_tissue0.65392866
154MP0003953_abnormal_hormone_level0.64466307
155MP0010368_abnormal_lymphatic_system0.64460415
156MP0005375_adipose_tissue_phenotype0.64428459
157MP0009765_abnormal_xenobiotic_induced0.63209417
158MP0005647_abnormal_sex_gland0.62990120
159MP0002419_abnormal_innate_immunity0.62512894
160MP0006054_spinal_hemorrhage0.60858278
161MP0001790_abnormal_immune_system0.59444552

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.32205745
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.85975696
3Intrahepatic cholestasis (HP:0001406)4.63750547
4Xanthomatosis (HP:0000991)4.52398261
5Complement deficiency (HP:0004431)4.43036440
6Abnormality of glycolipid metabolism (HP:0010969)4.36718197
7Abnormality of liposaccharide metabolism (HP:0010968)4.36718197
8Abnormality of glycosphingolipid metabolism (HP:0004343)4.36718197
9Abnormality of monocarboxylic acid metabolism (HP:0010996)4.29968718
10Protrusio acetabuli (HP:0003179)3.97613032
11Premature rupture of membranes (HP:0001788)3.94042848
12Abnormality of the common coagulation pathway (HP:0010990)3.88066852
13Prolonged partial thromboplastin time (HP:0003645)3.76151019
14Vertebral compression fractures (HP:0002953)3.57222616
15Ketosis (HP:0001946)3.55082577
16Hyperlipoproteinemia (HP:0010980)3.44058917
17Hypoglycemic coma (HP:0001325)3.43613523
18Abnormality of complement system (HP:0005339)3.39340103
19Abnormality of the intrinsic pathway (HP:0010989)3.38003747
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.29624566
21Hypobetalipoproteinemia (HP:0003563)3.25371598
22Mucopolysacchariduria (HP:0008155)3.25058829
23Urinary glycosaminoglycan excretion (HP:0003541)3.25058829
24Ketoacidosis (HP:0001993)3.22396999
25Systemic lupus erythematosus (HP:0002725)3.19491297
26Dysostosis multiplex (HP:0000943)3.14818009
27Joint hemorrhage (HP:0005261)3.13492596
28Fat malabsorption (HP:0002630)3.12958681
29Eczematoid dermatitis (HP:0000976)3.05160151
30Abnormality of polysaccharide metabolism (HP:0011012)3.02660355
31Abnormality of glycosaminoglycan metabolism (HP:0004371)3.02660355
32Abnormality of mucopolysaccharide metabolism (HP:0011020)3.02660355
33Myocardial infarction (HP:0001658)2.98632531
34Abnormality of macrophages (HP:0004311)2.93699510
35Epidermoid cyst (HP:0200040)2.87108781
36Hyperammonemia (HP:0001987)2.86412600
37Hypoalphalipoproteinemia (HP:0003233)2.82011976
38Conjugated hyperbilirubinemia (HP:0002908)2.80872077
39Hypolipoproteinemia (HP:0010981)2.78562265
40Abnormality of sulfur amino acid metabolism (HP:0004339)2.75878859
41Hypoglycemic seizures (HP:0002173)2.69733686
42Loss of speech (HP:0002371)2.63566395
43Gout (HP:0001997)2.62990726
44Glomerulonephritis (HP:0000099)2.62198860
45Vacuolated lymphocytes (HP:0001922)2.60125159
46Abnormality of purine metabolism (HP:0004352)2.59986722
47Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.53790498
48Hyperglycinuria (HP:0003108)2.53040644
49Skin nodule (HP:0200036)2.50042499
50Late onset (HP:0003584)2.49726295
51Mitral stenosis (HP:0001718)2.48098664
52Cervical subluxation (HP:0003308)2.44260431
53Hyperinsulinemic hypoglycemia (HP:0000825)2.42175440
54Recurrent gram-negative bacterial infections (HP:0005420)2.41159799
55Hypercholesterolemia (HP:0003124)2.40246917
56Arterial tortuosity (HP:0005116)2.39643974
57Aortic dissection (HP:0002647)2.38155648
58Vascular tortuosity (HP:0004948)2.37324772
59Atrophic scars (HP:0001075)2.36446956
60Abnormality of glycine metabolism (HP:0010895)2.36035451
61Abnormality of serine family amino acid metabolism (HP:0010894)2.36035451
62Thin bony cortex (HP:0002753)2.36026618
63Recurrent abscess formation (HP:0002722)2.35369506
64Hyperglycinemia (HP:0002154)2.32321373
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.31637033
66Amyloidosis (HP:0011034)2.30427520
67Increased neuronal autofluorescent lipopigment (HP:0002074)2.28214673
68Spondylolisthesis (HP:0003302)2.25583487
69Steatorrhea (HP:0002570)2.24938552
70Abnormality of fatty-acid metabolism (HP:0004359)2.21379431
71Sensorimotor neuropathy (HP:0007141)2.19373800
72Hepatocellular carcinoma (HP:0001402)2.16858211
73Hydroxyprolinuria (HP:0003080)2.16722283
74Abnormality of proline metabolism (HP:0010907)2.16722283
75Nuclear cataract (HP:0100018)2.15568518
76Menorrhagia (HP:0000132)2.15121251
77Purpura (HP:0000979)2.14172119
78Hyperbilirubinemia (HP:0002904)2.13870483
79Blue sclerae (HP:0000592)2.13192713
80Abnormality of nucleobase metabolism (HP:0010932)2.12977192
81Abnormality of aspartate family amino acid metabolism (HP:0010899)2.12542642
82Esophageal varix (HP:0002040)2.11781432
83Recurrent bacterial skin infections (HP:0005406)2.11680696
84Protuberant abdomen (HP:0001538)2.08756217
85J-shaped sella turcica (HP:0002680)2.08319651
86Myositis (HP:0100614)2.07857227
87Nephritis (HP:0000123)2.07613043
88Hyperglycemia (HP:0003074)2.05932067
89Wormian bones (HP:0002645)2.04957197
90Pancreatitis (HP:0001733)2.03829395
91Gingivitis (HP:0000230)2.03365019
92Dilatation of the ascending aorta (HP:0005111)2.03314093
93Vascular calcification (HP:0004934)1.99692159
94Symptomatic seizures (HP:0011145)1.97953127
95Fragile skin (HP:0001030)1.96666655
96Hyperacusis (HP:0010780)1.96617413
97Orchitis (HP:0100796)1.94642470
98Bone pain (HP:0002653)1.93521621
99Cellulitis (HP:0100658)1.93242256
100Abnormality of endocrine pancreas physiology (HP:0012093)1.93062127
101Abnormality of the pancreatic islet cells (HP:0006476)1.93062127
102Bladder diverticulum (HP:0000015)1.92937194
103Thoracic kyphosis (HP:0002942)1.91932722
104Pathologic fracture (HP:0002756)1.91774883
105Osteolytic defects of the hand bones (HP:0009699)1.91489902
106Osteolytic defects of the phalanges of the hand (HP:0009771)1.91489902
107Gingival bleeding (HP:0000225)1.90385978
108Flat acetabular roof (HP:0003180)1.90024896
109Asymmetric septal hypertrophy (HP:0001670)1.89030877
110Cardiovascular calcification (HP:0011915)1.88868363
111Cerebral aneurysm (HP:0004944)1.88226227
112Increased CSF protein (HP:0002922)1.86877715
113Increased variability in muscle fiber diameter (HP:0003557)1.86580365
114Increased cerebral lipofuscin (HP:0011813)1.86456278
115Abnormality of dentin (HP:0010299)1.85647536
116Retinal atrophy (HP:0001105)1.84676066
117Abdominal distention (HP:0003270)1.84539225
118Spastic diplegia (HP:0001264)1.83973884
119Biconcave vertebral bodies (HP:0004586)1.83879575
120Neurofibrillary tangles (HP:0002185)1.83427751
121Abnormality of the thoracic spine (HP:0100711)1.83358361
122Abnormality of methionine metabolism (HP:0010901)1.82363584
123Distal upper limb amyotrophy (HP:0007149)1.82361863
124Upper limb amyotrophy (HP:0009129)1.82361863
125Achilles tendon contracture (HP:0001771)1.81708718
126Abnormal cartilage morphology (HP:0002763)1.81129021
127Axonal loss (HP:0003447)1.81056735
128Back pain (HP:0003418)1.78950496
129Hemorrhage of the eye (HP:0011885)1.78931140
130Turricephaly (HP:0000262)1.78883958
131Global brain atrophy (HP:0002283)1.78669515
132Abnormal enzyme/coenzyme activity (HP:0012379)1.78027906
133Malnutrition (HP:0004395)1.77817415
134Neonatal onset (HP:0003623)1.77753196
135Cerebral inclusion bodies (HP:0100314)1.77080382
136Increased connective tissue (HP:0009025)1.77070019
137Broad face (HP:0000283)1.76421053
138Peritonitis (HP:0002586)1.74768727
139Aortic aneurysm (HP:0004942)1.74228065
140Irritability (HP:0000737)1.74038595
141Joint stiffness (HP:0001387)1.73638288
142Polygenic inheritance (HP:0010982)1.73544581
143Stroke (HP:0001297)1.72135284
144Genu recurvatum (HP:0002816)1.71475588
145Spontaneous hematomas (HP:0007420)1.71211629
146Polycythemia (HP:0001901)1.70661805
147Upper motor neuron abnormality (HP:0002127)1.70341775
148Neuronal loss in central nervous system (HP:0002529)1.69442527
149Elevated alkaline phosphatase (HP:0003155)1.68120449
150Delayed CNS myelination (HP:0002188)1.68067767
151Abnormality of the Achilles tendon (HP:0005109)1.68029187
152Generalized aminoaciduria (HP:0002909)1.67998557
153Cardiomegaly (HP:0001640)1.67575231
154Hyperparathyroidism (HP:0000843)1.66976121
155Distal lower limb muscle weakness (HP:0009053)1.66745558
156Colitis (HP:0002583)1.66644252
157Centrally nucleated skeletal muscle fibers (HP:0003687)1.65967117
158Metabolic acidosis (HP:0001942)1.65775010
159Supranuclear gaze palsy (HP:0000605)1.65765323
160Interstitial pulmonary disease (HP:0006530)1.65099518
161Aneurysm (HP:0002617)1.64940614
162Apathy (HP:0000741)1.63467830
163Abnormality of skeletal muscle fiber size (HP:0012084)1.63198073
164Short nail (HP:0001799)1.62971476
165Coxa vara (HP:0002812)1.62632038
166Abnormality of the peritoneum (HP:0002585)1.62552462
167Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.62202822
168Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.62052702
169Diminished motivation (HP:0000745)1.61481489
170Mitral regurgitation (HP:0001653)1.61248937
171Ulnar bowing (HP:0003031)1.61135186

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.41386486
2TRIB33.86728256
3TAOK33.49497025
4SIK13.03619236
5BCKDK2.88746772
6FGFR42.77184640
7PKN22.75685798
8PRPF4B2.53409478
9INSRR2.34531492
10MST1R2.22403390
11PTK62.12463066
12FRK2.01900841
13EPHB11.98354153
14SMG11.84821232
15EEF2K1.73167484
16RIPK11.72323832
17RIPK41.54747993
18YES11.53934974
19JAK11.53896446
20TESK11.50730635
21MOS1.49531965
22TYK21.49344862
23NME21.48118249
24PDGFRA1.44929283
25EPHA21.41476698
26PAK41.40884682
27CDC42BPA1.37236455
28FLT31.35774859
29TESK21.32838493
30MAPK151.29954006
31CDK121.29329024
32TBK11.28309624
33TGFBR21.28109577
34MAP3K111.25083813
35JAK21.19139297
36MAP3K101.19088450
37MAP3K21.18034591
38RET1.17719901
39PRKCH1.16702473
40CAMK1D1.13727533
41FGFR31.10142703
42SCYL21.08829156
43PIK3CG1.08533325
44LRRK21.07036040
45PTK21.06750172
46CAMK1G1.06261278
47IRAK41.05281465
48TAOK21.05227898
49NTRK11.04397780
50EPHA31.03159643
51MAP4K11.01981353
52MAP3K11.00818485
53DAPK21.00354393
54FGFR20.99385238
55CAMKK10.96577920
56MARK20.95998792
57CSK0.93837429
58ZAP700.90576150
59FGR0.90401555
60MAP2K20.88542888
61ARAF0.87358243
62MET0.86052936
63WNK40.85923629
64MAP3K70.85752584
65HIPK20.85104738
66GRK60.84234370
67LATS20.83920837
68KSR20.82774994
69DYRK1B0.78986180
70PIM20.77738691
71JAK30.76356517
72LATS10.76213503
73ITK0.75773797
74MAP3K60.74393703
75MAP3K130.73401061
76MAPK110.72427857
77EPHB20.72421446
78TAOK10.71889966
79PDGFRB0.71666794
80MATK0.71161071
81PDPK10.70934360
82CDK60.70433681
83FER0.69931743
84BMX0.68622841
85DDR20.65987141
86IRAK30.64693422
87KIT0.62835291
88IKBKE0.61689364
89CSF1R0.61481928
90PRKD30.61261522
91FES0.59961727
92MAP2K40.58969070
93SIK30.58426428
94CAMKK20.57172815
95MAPKAPK20.56030422
96SIK20.55729409
97PDK10.55350590
98MAPKAPK30.54752875
99RPS6KC10.54071326
100RPS6KL10.54071326
101LMTK20.53863733
102NEK90.53691507
103STK380.53681412
104PRKD10.52056132
105TTN0.51499414
106BLK0.51145811
107ERBB40.50835319
108PRKG20.50005566
109GSK3A0.49247661
110SGK30.49133686
111MAP2K30.47554266
112STK100.47512051
113IRAK20.47437873
114MAP3K30.47358155
115RPS6KA20.46843603
116PRKAA20.46307603
117MAP2K10.46097087
118PAK30.46043095
119MAPK70.45902578
120ABL20.45598115
121HCK0.44961758
122LYN0.44719293
123MAP3K90.42932486
124PRKD20.42836361
125MTOR0.42049295
126BTK0.41723214
127MAP3K140.41534402
128IGF1R0.40271702
129TRPM70.40054951
130EGFR0.39395988
131PRKCZ0.38894928
132ICK0.38493890
133MAP3K80.38418809
134KDR0.36977087
135PAK20.36008798
136PRKAA10.35876167

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.47967859
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.40223870
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.84836312
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61612328
5Arginine biosynthesis_Homo sapiens_hsa002202.53081406
6Tryptophan metabolism_Homo sapiens_hsa003802.34382246
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.32252185
8Complement and coagulation cascades_Homo sapiens_hsa046102.31747085
9Sulfur metabolism_Homo sapiens_hsa009202.20106727
10Fatty acid degradation_Homo sapiens_hsa000712.17446855
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13384926
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.94572923
13Staphylococcus aureus infection_Homo sapiens_hsa051501.92019386
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87868655
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.83394186
16Caffeine metabolism_Homo sapiens_hsa002321.75661552
17Butanoate metabolism_Homo sapiens_hsa006501.72368451
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69769949
19PPAR signaling pathway_Homo sapiens_hsa033201.66368087
20Fat digestion and absorption_Homo sapiens_hsa049751.65741918
21Bile secretion_Homo sapiens_hsa049761.63065142
22Leishmaniasis_Homo sapiens_hsa051401.58970818
23Histidine metabolism_Homo sapiens_hsa003401.53305701
24Fatty acid metabolism_Homo sapiens_hsa012121.49940063
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48292860
26Peroxisome_Homo sapiens_hsa041461.46366863
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44864063
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44505746
29Chronic myeloid leukemia_Homo sapiens_hsa052201.40770478
30ABC transporters_Homo sapiens_hsa020101.38149600
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37083849
32Propanoate metabolism_Homo sapiens_hsa006401.36298240
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33986331
34Acute myeloid leukemia_Homo sapiens_hsa052211.33151357
35Malaria_Homo sapiens_hsa051441.31823596
36Starch and sucrose metabolism_Homo sapiens_hsa005001.30879585
37Phagosome_Homo sapiens_hsa041451.28980878
38beta-Alanine metabolism_Homo sapiens_hsa004101.28874151
39Tuberculosis_Homo sapiens_hsa051521.26931827
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25912465
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25204099
42Selenocompound metabolism_Homo sapiens_hsa004501.24835735
43Pancreatic cancer_Homo sapiens_hsa052121.21879748
44Chemical carcinogenesis_Homo sapiens_hsa052041.20983177
45B cell receptor signaling pathway_Homo sapiens_hsa046621.17813626
46Non-small cell lung cancer_Homo sapiens_hsa052231.15614880
47Toxoplasmosis_Homo sapiens_hsa051451.15236912
48TNF signaling pathway_Homo sapiens_hsa046681.14075270
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13695524
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13129624
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.11899177
52Salmonella infection_Homo sapiens_hsa051321.09242246
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.07845113
54Notch signaling pathway_Homo sapiens_hsa043301.07791621
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.05932369
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04166358
57Lysosome_Homo sapiens_hsa041421.01583673
58NF-kappa B signaling pathway_Homo sapiens_hsa040641.00081114
59Phenylalanine metabolism_Homo sapiens_hsa003600.99715349
60VEGF signaling pathway_Homo sapiens_hsa043700.99130246
61Other glycan degradation_Homo sapiens_hsa005110.98369008
62Influenza A_Homo sapiens_hsa051640.97290327
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97134021
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.96885275
65* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96587575
66Sulfur relay system_Homo sapiens_hsa041220.96048534
67Vibrio cholerae infection_Homo sapiens_hsa051100.90836472
68Hepatitis B_Homo sapiens_hsa051610.90458923
69Glycerolipid metabolism_Homo sapiens_hsa005610.90097106
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.89847146
71Antigen processing and presentation_Homo sapiens_hsa046120.89706776
72Focal adhesion_Homo sapiens_hsa045100.87438286
73Apoptosis_Homo sapiens_hsa042100.86435134
74Retinol metabolism_Homo sapiens_hsa008300.85766918
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85669742
76Lysine degradation_Homo sapiens_hsa003100.84556968
77Pyruvate metabolism_Homo sapiens_hsa006200.84280870
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83626920
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.82860943
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82306896
81Shigellosis_Homo sapiens_hsa051310.82169588
82Rheumatoid arthritis_Homo sapiens_hsa053230.81704618
83Viral myocarditis_Homo sapiens_hsa054160.81576590
84Folate biosynthesis_Homo sapiens_hsa007900.81268620
85ECM-receptor interaction_Homo sapiens_hsa045120.80916469
86Allograft rejection_Homo sapiens_hsa053300.80229299
87Tyrosine metabolism_Homo sapiens_hsa003500.80156738
88Renal cell carcinoma_Homo sapiens_hsa052110.78794243
89Proteoglycans in cancer_Homo sapiens_hsa052050.78408938
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77764812
91Measles_Homo sapiens_hsa051620.77658179
92Endocytosis_Homo sapiens_hsa041440.76363687
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75725012
94Insulin resistance_Homo sapiens_hsa049310.75310829
95Small cell lung cancer_Homo sapiens_hsa052220.73606156
96Autoimmune thyroid disease_Homo sapiens_hsa053200.72889593
97Prion diseases_Homo sapiens_hsa050200.72696396
98Graft-versus-host disease_Homo sapiens_hsa053320.71851966
99Chemokine signaling pathway_Homo sapiens_hsa040620.70603221
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70385845
101Endometrial cancer_Homo sapiens_hsa052130.70310142
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.69860416
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69433202
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69296176
105Glioma_Homo sapiens_hsa052140.69186606
106Vitamin digestion and absorption_Homo sapiens_hsa049770.67754916
107Legionellosis_Homo sapiens_hsa051340.67431831
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66384137
109Pancreatic secretion_Homo sapiens_hsa049720.65773714
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64838361
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.64102340
112Hematopoietic cell lineage_Homo sapiens_hsa046400.62603649
113Sphingolipid metabolism_Homo sapiens_hsa006000.61919744
114Protein digestion and absorption_Homo sapiens_hsa049740.61832612
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61682047
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61667059
117T cell receptor signaling pathway_Homo sapiens_hsa046600.61624790
118Arginine and proline metabolism_Homo sapiens_hsa003300.60471474
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.60429300
120Thyroid cancer_Homo sapiens_hsa052160.60401146
121Platelet activation_Homo sapiens_hsa046110.59032577
122GnRH signaling pathway_Homo sapiens_hsa049120.58389229
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.58233734
124Biosynthesis of amino acids_Homo sapiens_hsa012300.57472386
125Carbon metabolism_Homo sapiens_hsa012000.57411947
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57278151
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56995826
128Type II diabetes mellitus_Homo sapiens_hsa049300.54647248
129Fatty acid elongation_Homo sapiens_hsa000620.54314963
130HIF-1 signaling pathway_Homo sapiens_hsa040660.54200568
131mTOR signaling pathway_Homo sapiens_hsa041500.53547997
132Herpes simplex infection_Homo sapiens_hsa051680.53532914
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53359420
134Steroid biosynthesis_Homo sapiens_hsa001000.52031962
135African trypanosomiasis_Homo sapiens_hsa051430.51260452
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.50949055
137Renin-angiotensin system_Homo sapiens_hsa046140.50166659
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.49777638
139Estrogen signaling pathway_Homo sapiens_hsa049150.48705550
140Thyroid hormone synthesis_Homo sapiens_hsa049180.48398235
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46089429
142Galactose metabolism_Homo sapiens_hsa000520.42273603
143Fatty acid biosynthesis_Homo sapiens_hsa000610.40207087
144N-Glycan biosynthesis_Homo sapiens_hsa005100.40159146
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38111824
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36901468
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35116935
148Insulin secretion_Homo sapiens_hsa049110.32262245
149Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31649071
150Amoebiasis_Homo sapiens_hsa051460.31118560
151Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30726719
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28388723
153AMPK signaling pathway_Homo sapiens_hsa041520.27369780
154Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24729289
155Glucagon signaling pathway_Homo sapiens_hsa049220.23541963
156Insulin signaling pathway_Homo sapiens_hsa049100.21318801
157Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21188723
158Pertussis_Homo sapiens_hsa051330.21151358
159Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20806783
160Prolactin signaling pathway_Homo sapiens_hsa049170.20773831
161Osteoclast differentiation_Homo sapiens_hsa043800.19677051
162Bladder cancer_Homo sapiens_hsa052190.19544619
163Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19466213
164Pentose phosphate pathway_Homo sapiens_hsa000300.19218542
165Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17812410
166Fructose and mannose metabolism_Homo sapiens_hsa000510.16777143
167Hepatitis C_Homo sapiens_hsa051600.16164452
168Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15260513
169alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14687174
170Glutathione metabolism_Homo sapiens_hsa004800.14248375

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