OSBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.90718201
2regulation of RNA export from nucleus (GO:0046831)4.26573667
3desmosome organization (GO:0002934)4.25261409
4nuclear pore organization (GO:0006999)4.16280331
5lysine metabolic process (GO:0006553)3.97311710
6lysine catabolic process (GO:0006554)3.97311710
7regulation of nucleobase-containing compound transport (GO:0032239)3.95557276
8L-phenylalanine catabolic process (GO:0006559)3.88022761
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.88022761
10alpha-linolenic acid metabolic process (GO:0036109)3.87212200
11carnitine shuttle (GO:0006853)3.76582305
12fatty acid transmembrane transport (GO:1902001)3.68609767
13vesicle coating (GO:0006901)3.68564124
14histone H3-K36 demethylation (GO:0070544)3.66640059
152-oxoglutarate metabolic process (GO:0006103)3.63212856
16mitotic chromosome condensation (GO:0007076)3.62565988
17L-phenylalanine metabolic process (GO:0006558)3.62551350
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.62551350
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.47425999
20mitotic sister chromatid cohesion (GO:0007064)3.40996504
21COPI coating of Golgi vesicle (GO:0048205)3.39967431
22Golgi transport vesicle coating (GO:0048200)3.39967431
23positive regulation of fatty acid beta-oxidation (GO:0032000)3.38776896
24pore complex assembly (GO:0046931)3.31697846
25aspartate family amino acid catabolic process (GO:0009068)3.30327246
26regulation of NFAT protein import into nucleus (GO:0051532)3.29851047
27regulation of cholesterol homeostasis (GO:2000188)3.29274220
284-hydroxyproline metabolic process (GO:0019471)3.28189938
29dicarboxylic acid biosynthetic process (GO:0043650)3.27018824
30regulation of fatty acid beta-oxidation (GO:0031998)3.26614238
31peptidyl-glutamic acid carboxylation (GO:0017187)3.22807734
32protein carboxylation (GO:0018214)3.22807734
33hemidesmosome assembly (GO:0031581)3.22521433
34histone H3-K9 demethylation (GO:0033169)3.21336949
35regulation of early endosome to late endosome transport (GO:2000641)3.20679839
36triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.19272964
37sulfur amino acid catabolic process (GO:0000098)3.17068314
38cytoskeletal anchoring at plasma membrane (GO:0007016)3.16514125
39phospholipid homeostasis (GO:0055091)3.16412415
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.16341778
41negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.15742703
42fatty acid beta-oxidation (GO:0006635)3.13485459
43kynurenine metabolic process (GO:0070189)3.12075345
44tricarboxylic acid metabolic process (GO:0072350)3.11414995
45aromatic amino acid family catabolic process (GO:0009074)3.10629987
46plasma membrane repair (GO:0001778)3.09905895
47glyoxylate metabolic process (GO:0046487)3.08779572
48regulation of triglyceride catabolic process (GO:0010896)3.06333349
49cell-substrate junction assembly (GO:0007044)3.00678075
50focal adhesion assembly (GO:0048041)2.99897680
51cell-substrate adherens junction assembly (GO:0007045)2.99897680
52skin morphogenesis (GO:0043589)2.99804931
53valine metabolic process (GO:0006573)2.98690250
54sarcomere organization (GO:0045214)2.98599652
55adherens junction assembly (GO:0034333)2.97732962
56embryonic process involved in female pregnancy (GO:0060136)2.97670793
57regulation of fatty acid oxidation (GO:0046320)2.97254172
58positive regulation of lipid catabolic process (GO:0050996)2.93537285
59cysteine metabolic process (GO:0006534)2.93015925
60negative regulation of fibrinolysis (GO:0051918)2.92877570
61COPII vesicle coating (GO:0048208)2.92370514
62fatty acid oxidation (GO:0019395)2.91977208
63protein localization to endosome (GO:0036010)2.91384566
64urea cycle (GO:0000050)2.91326958
65urea metabolic process (GO:0019627)2.91326958
66positive regulation of fatty acid oxidation (GO:0046321)2.91219717
67activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.90565416
68carnitine transmembrane transport (GO:1902603)2.89313938
69complement activation, alternative pathway (GO:0006957)2.88890060
70acetyl-CoA metabolic process (GO:0006084)2.88366248
71negative regulation of potassium ion transmembrane transport (GO:1901380)2.87789823
72epithelial cell-cell adhesion (GO:0090136)2.87591857
73lipid oxidation (GO:0034440)2.83766079
74amino-acid betaine metabolic process (GO:0006577)2.83537689
75carnitine transport (GO:0015879)2.83280116
76amino-acid betaine transport (GO:0015838)2.83280116
77fatty acid catabolic process (GO:0009062)2.82853846
78bundle of His cell to Purkinje myocyte communication (GO:0086069)2.82000094
79protein localization to microtubule (GO:0035372)2.81143858
80positive regulation of histone deacetylation (GO:0031065)2.79577760
81plasma lipoprotein particle clearance (GO:0034381)2.79556731
82short-chain fatty acid metabolic process (GO:0046459)2.78712651
83low-density lipoprotein particle clearance (GO:0034383)2.75055701
84cardiac myofibril assembly (GO:0055003)2.74711820
85glutamate metabolic process (GO:0006536)2.74323210
86growth hormone receptor signaling pathway (GO:0060396)2.72695459
87histone lysine demethylation (GO:0070076)2.72089447
88positive regulation of nuclease activity (GO:0032075)2.72049308
89regulation of protein activation cascade (GO:2000257)2.69766661
90high-density lipoprotein particle remodeling (GO:0034375)2.69631878
91cellular modified amino acid catabolic process (GO:0042219)2.68900055
92proline biosynthetic process (GO:0006561)2.68380533
93bile acid biosynthetic process (GO:0006699)2.68181482
94monocarboxylic acid catabolic process (GO:0072329)2.67019996
95cellular ketone body metabolic process (GO:0046950)2.66312416
96positive regulation of glycolytic process (GO:0045821)2.65196398
97activation of Rac GTPase activity (GO:0032863)2.65140813
98regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.64075181
99creatine metabolic process (GO:0006600)2.62875373
100positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.62219485
101histone demethylation (GO:0016577)2.61833209
102regulation of sequestering of triglyceride (GO:0010889)2.61653654
103oxaloacetate metabolic process (GO:0006107)2.61280933
104protein retention in ER lumen (GO:0006621)2.61157401
105intracellular lipid transport (GO:0032365)2.61100328
106homocysteine metabolic process (GO:0050667)2.59605495
107nitrogen cycle metabolic process (GO:0071941)2.58691559
108iron ion import (GO:0097286)2.58521866
109regulation of glucose import in response to insulin stimulus (GO:2001273)2.57738725
110hypotonic response (GO:0006971)2.56627088
111regulation of complement activation (GO:0030449)2.56123787
112hormone catabolic process (GO:0042447)2.55758117
113ethanol oxidation (GO:0006069)2.55342912
114intestinal cholesterol absorption (GO:0030299)2.54826124
115positive regulation of triglyceride metabolic process (GO:0090208)2.54591354
116positive regulation of glycogen biosynthetic process (GO:0045725)2.53946085
117reverse cholesterol transport (GO:0043691)2.53685868
118macroautophagy (GO:0016236)2.53042959
119insulin-like growth factor receptor signaling pathway (GO:0048009)2.51161889
120regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51050700
121retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.50900622
122carnitine metabolic process (GO:0009437)2.50764599
123branching involved in mammary gland duct morphogenesis (GO:0060444)2.50583211
124negative regulation of cholesterol transport (GO:0032375)2.49115271
125negative regulation of sterol transport (GO:0032372)2.49115271
126cell adhesion mediated by integrin (GO:0033627)2.48403096
127regulation of fibrinolysis (GO:0051917)2.47565268
128endoplasmic reticulum unfolded protein response (GO:0030968)2.47389774
129regulation of histone H3-K27 methylation (GO:0061085)2.47354809
130indole-containing compound catabolic process (GO:0042436)2.46912325
131indolalkylamine catabolic process (GO:0046218)2.46912325
132tryptophan catabolic process (GO:0006569)2.46912325
133cellular response to unfolded protein (GO:0034620)2.46817027
134protein export from nucleus (GO:0006611)2.46371681
135peptidyl-lysine dimethylation (GO:0018027)2.45956645
136negative regulation of fatty acid biosynthetic process (GO:0045717)2.45667119
137tricarboxylic acid cycle (GO:0006099)2.45594772
138regulation of nuclease activity (GO:0032069)2.45422577
139drug transmembrane transport (GO:0006855)2.45209665
140bile acid metabolic process (GO:0008206)2.44572288
141peptidyl-threonine modification (GO:0018210)2.44387918
142regulation of water loss via skin (GO:0033561)2.44327589
143ER-nucleus signaling pathway (GO:0006984)2.44140196
144positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.43291612
145ER overload response (GO:0006983)2.42337455
146negative regulation of cell size (GO:0045792)2.41531721
147regulation of translational fidelity (GO:0006450)2.40143705
148protein hydroxylation (GO:0018126)2.39199138
149stress fiber assembly (GO:0043149)2.38440655
150nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.34173444
151RNA stabilization (GO:0043489)2.33980241
152mRNA stabilization (GO:0048255)2.33980241
153cellular protein complex localization (GO:0034629)2.33445682
154positive regulation of p38MAPK cascade (GO:1900745)2.33228167
155positive regulation of macroautophagy (GO:0016239)2.32585787
156peptidyl-proline hydroxylation (GO:0019511)2.30877134
157glucocorticoid receptor signaling pathway (GO:0042921)2.30624661
158protein demethylation (GO:0006482)2.29353676
159protein dealkylation (GO:0008214)2.29353676
160peptidyl-threonine phosphorylation (GO:0018107)2.29141585
161paraxial mesoderm development (GO:0048339)2.28124152
162negative regulation of fatty acid transport (GO:2000192)2.27299211
163positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.25856394
164NADH metabolic process (GO:0006734)2.25512393
165mammary gland epithelial cell proliferation (GO:0033598)2.25205801
166hippo signaling (GO:0035329)2.24302638
167DNA synthesis involved in DNA repair (GO:0000731)2.24139406
168regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.23032385
169negative regulation of protein localization to plasma membrane (GO:1903077)2.22180477
170negative regulation of histone methylation (GO:0031061)2.21910680
171regulation of transforming growth factor beta1 production (GO:0032908)2.21770204
172Golgi organization (GO:0007030)2.20972220
173regulation of transforming growth factor beta2 production (GO:0032909)2.20699905
174cellular response to topologically incorrect protein (GO:0035967)2.20585136
175response to epidermal growth factor (GO:0070849)2.20405147
176cellular response to epidermal growth factor stimulus (GO:0071364)2.19879124
177response to endoplasmic reticulum stress (GO:0034976)2.19776636
178negative regulation of DNA repair (GO:0045738)2.19502866
179maternal placenta development (GO:0001893)2.18217708
180NLS-bearing protein import into nucleus (GO:0006607)2.13477652
181negative regulation of anoikis (GO:2000811)2.13096315
182surfactant homeostasis (GO:0043129)2.09300449
183basement membrane organization (GO:0071711)2.09030533

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.65737030
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.17005488
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.80696163
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.76424597
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.69746787
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.67382981
7E2F7_22180533_ChIP-Seq_HELA_Human3.07455564
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.04142204
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.77341657
10AR_21909140_ChIP-Seq_LNCAP_Human2.64966733
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58852902
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.46741471
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.43847145
14CLOCK_20551151_ChIP-Seq_293T_Human2.36735910
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23978932
16PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.06524336
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.05705445
18ZNF263_19887448_ChIP-Seq_K562_Human1.91426266
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91052889
20* FOXA2_19822575_ChIP-Seq_HepG2_Human1.85429588
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82807003
22EGR1_23403033_ChIP-Seq_LIVER_Mouse1.80746960
23TBX20_22328084_ChIP-Seq_HEART_Mouse1.79859021
24TBX20_22080862_ChIP-Seq_HEART_Mouse1.79859021
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.78152050
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77486318
27MYC_22102868_ChIP-Seq_BL_Human1.77312480
28* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74880341
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.73321509
30GATA1_22025678_ChIP-Seq_K562_Human1.73196244
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.72996943
32SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.72996943
33* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.72166891
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71362070
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.71023896
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.65797155
37* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.63094524
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61206132
39CHD1_26751641_Chip-Seq_LNCaP_Human1.59387209
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.52502356
41TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.51668381
42GATA1_19941826_ChIP-Seq_K562_Human1.46934413
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45577413
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45161634
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42394274
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.39375600
47KDM2B_26808549_Chip-Seq_DND41_Human1.39328857
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37014396
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36868797
50* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.36626919
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35582361
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32637721
53TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32285447
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32011049
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32004233
56UBF1/2_26484160_Chip-Seq_HMECs_Human1.30321164
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29227496
58TCF7_22412390_ChIP-Seq_EML_Mouse1.27914914
59SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27752293
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27303344
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27224303
62NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.26992622
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26110061
64CTNNB1_20460455_ChIP-Seq_HCT116_Human1.25909737
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25368004
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24753319
67LXR_22292898_ChIP-Seq_THP-1_Human1.24616930
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.23955960
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.21282178
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20046014
71* RACK7_27058665_Chip-Seq_MCF-7_Human1.19903729
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19556823
73* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19451127
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19332480
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18698313
76* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18307738
77KDM2B_26808549_Chip-Seq_K562_Human1.17695211
78* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16927628
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15992992
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15576344
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14978248
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14356123
83FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14353515
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14209134
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.13731278
86GATA2_19941826_ChIP-Seq_K562_Human1.13325910
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12925598
88EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11668979
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11589224
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10855092
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10320943
92* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09959714
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09592703
94GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.08175829
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07647691
96* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07388677
97TP63_17297297_ChIP-ChIP_HaCaT_Human1.06476013
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06340509
99* ELK3_25401928_ChIP-Seq_HUVEC_Human1.06114370
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05031377
101* GATA6_25053715_ChIP-Seq_YYC3_Human1.04352470
102NCOR1_26117541_ChIP-Seq_K562_Human1.03783308
103TFEB_21752829_ChIP-Seq_HELA_Human1.02344094
104DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01789419
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01143112
106GATA4_25053715_ChIP-Seq_YYC3_Human1.01044226
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01043071
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00607957
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00154546
110* HNF4A_19822575_ChIP-Seq_HepG2_Human0.99958290
111CREB1_26743006_Chip-Seq_LNCaP_Human0.99571841
112* ATF3_27146783_Chip-Seq_COLON_Human0.98724174
113KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96969885
114KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96969885
115KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96969885
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96902414
117KDM2B_26808549_Chip-Seq_JURKAT_Human0.96890846
118* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93947664
119EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91878512
120NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91131626
121BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90940751
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89602361
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89577311
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89195832
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88123156
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88123156
127WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88096992
128FOXA1_25552417_ChIP-Seq_VCAP_Human0.87329748
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87095592
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86444166
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86399372
132EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85631424
133EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84945720
134E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84936532
135NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84823401
136FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84433347
137GATA1_19941827_ChIP-Seq_MEL_Mouse0.84141887
138HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83852316
139* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82972812
140DROSHA_22980978_ChIP-Seq_HELA_Human0.82837786
141SPI1_23127762_ChIP-Seq_K562_Human0.82382135
142CJUN_26792858_Chip-Seq_BT549_Human0.81973737

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.19594958
2MP0005360_urolithiasis4.00891232
3MP0002837_dystrophic_cardiac_calcinosis3.44331485
4MP0005365_abnormal_bile_salt3.41602748
5MP0005085_abnormal_gallbladder_physiolo3.31144941
6MP0003705_abnormal_hypodermis_morpholog3.04741589
7MP0005451_abnormal_body_composition3.00111173
8MP0003252_abnormal_bile_duct2.88217121
9MP0004233_abnormal_muscle_weight2.47014952
10MP0005409_darkened_coat_color2.46472776
11MP0008875_abnormal_xenobiotic_pharmacok2.40929805
12MP0004084_abnormal_cardiac_muscle2.38519501
13MP0004130_abnormal_muscle_cell2.37723968
14MP0003300_gastrointestinal_ulcer2.36063365
15MP0010234_abnormal_vibrissa_follicle2.27950057
16MP0002796_impaired_skin_barrier2.27638666
17MP0009840_abnormal_foam_cell2.15896138
18MP0010329_abnormal_lipoprotein_level2.09883320
19MP0003941_abnormal_skin_development2.09482868
20MP0005083_abnormal_biliary_tract2.05969704
21MP0001666_abnormal_nutrient_absorption2.05934558
22MP0003453_abnormal_keratinocyte_physiol1.96613912
23MP0004036_abnormal_muscle_relaxation1.94871821
24MP0003195_calcinosis1.93114890
25MP0002877_abnormal_melanocyte_morpholog1.87388296
26MP0000751_myopathy1.87008862
27MP0009780_abnormal_chondrocyte_physiolo1.86808997
28MP0008057_abnormal_DNA_replication1.82877112
29MP0005330_cardiomyopathy1.73830881
30MP0004087_abnormal_muscle_fiber1.72809525
31MP0003806_abnormal_nucleotide_metabolis1.70833018
32MP0003950_abnormal_plasma_membrane1.68888287
33MP0004185_abnormal_adipocyte_glucose1.68119985
34MP0005666_abnormal_adipose_tissue1.64523468
35MP0003191_abnormal_cellular_cholesterol1.59631060
36MP0002118_abnormal_lipid_homeostasis1.58824822
37MP0001730_embryonic_growth_arrest1.58617306
38MP0008438_abnormal_cutaneous_collagen1.58025135
39MP0010678_abnormal_skin_adnexa1.56850790
40MP0002060_abnormal_skin_morphology1.56641367
41MP0003566_abnormal_cell_adhesion1.51779279
42MP0008961_abnormal_basal_metabolism1.51761328
43MP0000609_abnormal_liver_physiology1.51265801
44MP0005332_abnormal_amino_acid1.51044381
45MP0004043_abnormal_pH_regulation1.49604389
46MP0010630_abnormal_cardiac_muscle1.47960556
47MP0005501_abnormal_skin_physiology1.45983795
48MP0005023_abnormal_wound_healing1.42430082
49MP0005375_adipose_tissue_phenotype1.41728444
50MP0000749_muscle_degeneration1.41558556
51MP0004215_abnormal_myocardial_fiber1.41353076
52MP0000747_muscle_weakness1.37896202
53MP0000678_abnormal_parathyroid_gland1.35033737
54MP0005319_abnormal_enzyme/_coenzyme1.33912406
55MP0000013_abnormal_adipose_tissue1.33212980
56MP0002269_muscular_atrophy1.31761070
57MP0004782_abnormal_surfactant_physiolog1.29768121
58MP0003646_muscle_fatigue1.29645917
59MP0010307_abnormal_tumor_latency1.28546489
60MP0000003_abnormal_adipose_tissue1.27916133
61MP0002909_abnormal_adrenal_gland1.27676186
62MP0001216_abnormal_epidermal_layer1.26488074
63MP0003693_abnormal_embryo_hatching1.26098673
64MP0009643_abnormal_urine_homeostasis1.25278399
65MP0008775_abnormal_heart_ventricle1.25155061
66MP0002972_abnormal_cardiac_muscle1.25100415
67MP0003868_abnormal_feces_composition1.23323112
68MP0002009_preneoplasia1.22671603
69MP0002086_abnormal_extraembryonic_tissu1.16405193
70MP0003984_embryonic_growth_retardation1.15603835
71MP0002078_abnormal_glucose_homeostasis1.15540241
72MP0005275_abnormal_skin_tensile1.14764638
73MP0005670_abnormal_white_adipose1.13940749
74MP0005257_abnormal_intraocular_pressure1.13671974
75MP0001544_abnormal_cardiovascular_syste1.13071730
76MP0005385_cardiovascular_system_phenoty1.13071730
77MP0001672_abnormal_embryogenesis/_devel1.13001710
78MP0005380_embryogenesis_phenotype1.13001710
79MP0006054_spinal_hemorrhage1.12912059
80MP0005620_abnormal_muscle_contractility1.11173446
81MP0002088_abnormal_embryonic_growth/wei1.10754611
82MP0003656_abnormal_erythrocyte_physiolo1.10293429
83MP0009672_abnormal_birth_weight1.10049344
84MP0002138_abnormal_hepatobiliary_system1.08521590
85MP0004957_abnormal_blastocyst_morpholog1.07371148
86MP0005584_abnormal_enzyme/coenzyme_acti1.06860337
87MP0004808_abnormal_hematopoietic_stem1.06676038
88MP0004510_myositis1.05789875
89MP0000537_abnormal_urethra_morphology1.05638721
90MP0001915_intracranial_hemorrhage1.05622087
91MP0005621_abnormal_cell_physiology1.05019291
92MP0000377_abnormal_hair_follicle1.04183117
93MP0006138_congestive_heart_failure1.02996814
94MP0000350_abnormal_cell_proliferation1.02797367
95MP0000762_abnormal_tongue_morphology1.02340359
96MP0005058_abnormal_lysosome_morphology1.02147709
97MP0003045_fibrosis1.02029763
98MP0010352_gastrointestinal_tract_polyps1.01414767
99MP0003303_peritoneal_inflammation1.00201737
100MP0003890_abnormal_embryonic-extraembry0.99738003
101MP0000627_abnormal_mammary_gland0.97515096
102MP0002971_abnormal_brown_adipose0.97426496
103MP0002098_abnormal_vibrissa_morphology0.95975727
104MP0005076_abnormal_cell_differentiation0.94804260
105MP0002106_abnormal_muscle_physiology0.94489177
106MP0004272_abnormal_basement_membrane0.92844334
107MP0002896_abnormal_bone_mineralization0.92646816
108MP0000467_abnormal_esophagus_morphology0.91979226
109MP0003111_abnormal_nucleus_morphology0.91976385
110MP0002396_abnormal_hematopoietic_system0.91452280
111MP0001661_extended_life_span0.90778678
112MP0000604_amyloidosis0.90285264
113MP0002084_abnormal_developmental_patter0.90136473
114MP0000759_abnormal_skeletal_muscle0.90087869
115MP0004947_skin_inflammation0.89601161
116MP0001881_abnormal_mammary_gland0.89498307
117MP0001765_abnormal_ion_homeostasis0.89103402
118MP0003329_amyloid_beta_deposits0.88767660
119MP0002080_prenatal_lethality0.88518012
120MP0003221_abnormal_cardiomyocyte_apopto0.87317202
121MP0004264_abnormal_extraembryonic_tissu0.85597073
122MP0000750_abnormal_muscle_regeneration0.85576905
123MP0010368_abnormal_lymphatic_system0.85568747
124MP0001697_abnormal_embryo_size0.85011411
125MP0009053_abnormal_anal_canal0.83981333
126MP0002234_abnormal_pharynx_morphology0.83582746
127MP0004197_abnormal_fetal_growth/weight/0.83365934
128MP0009384_cardiac_valve_regurgitation0.82430917
129MP0001944_abnormal_pancreas_morphology0.82186932
130MP0005220_abnormal_exocrine_pancreas0.82175342
131MP0005167_abnormal_blood-brain_barrier0.81930574
132MP0001756_abnormal_urination0.81549676
133MP0000733_abnormal_muscle_development0.81234264
134MP0004085_abnormal_heartbeat0.80731960
135MP0004145_abnormal_muscle_electrophysio0.79918291
136MP0005187_abnormal_penis_morphology0.78804149
137MP0000579_abnormal_nail_morphology0.78068159
138MP0000598_abnormal_liver_morphology0.77936660
139MP0005334_abnormal_fat_pad0.77602118
140MP0003077_abnormal_cell_cycle0.76794293
141MP0002089_abnormal_postnatal_growth/wei0.76609775
142MP0001849_ear_inflammation0.75646040
143MP0003283_abnormal_digestive_organ0.75645618
144MP0002928_abnormal_bile_duct0.75574367
145MP0005623_abnormal_meninges_morphology0.74766629
146MP0009931_abnormal_skin_appearance0.74011234
147MP0008260_abnormal_autophagy0.73966936
148MP0005369_muscle_phenotype0.73872257
149MP0003091_abnormal_cell_migration0.73480534
150MP0009703_decreased_birth_body0.73142566
151MP0003279_aneurysm0.72904353
152MP0000383_abnormal_hair_follicle0.71878904
153MP0002693_abnormal_pancreas_physiology0.71388014
154MP0002085_abnormal_embryonic_tissue0.70787191
155MP0004484_altered_response_of0.70190542
156MP0003959_abnormal_lean_body0.70002721
157MP0005535_abnormal_body_temperature0.68306376
158MP0002166_altered_tumor_susceptibility0.67876558

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.07254800
2Deep venous thrombosis (HP:0002625)4.03712997
3Intrahepatic cholestasis (HP:0001406)3.54892232
4Right ventricular cardiomyopathy (HP:0011663)3.51534772
5Xanthomatosis (HP:0000991)3.49453121
6Hyporeflexia of lower limbs (HP:0002600)3.49386943
7Ketoacidosis (HP:0001993)3.46024063
8Sudden death (HP:0001699)3.33636970
9Ketosis (HP:0001946)3.33591686
10Exercise-induced muscle cramps (HP:0003710)3.27236693
11Hyperinsulinemic hypoglycemia (HP:0000825)3.15446573
12Myoglobinuria (HP:0002913)3.08722023
13Abnormality of the common coagulation pathway (HP:0010990)3.01356399
14Exercise-induced myalgia (HP:0003738)2.98797034
15Abnormality of aromatic amino acid family metabolism (HP:0004338)2.94341481
16Abnormality of monocarboxylic acid metabolism (HP:0010996)2.91448084
17Hypoglycemic seizures (HP:0002173)2.85021033
18Flat acetabular roof (HP:0003180)2.82549400
19Ventricular tachycardia (HP:0004756)2.80228849
20Asymmetric septal hypertrophy (HP:0001670)2.76323551
21Muscle fiber splitting (HP:0003555)2.71340413
22Ankyloglossia (HP:0010296)2.70286055
23Increased connective tissue (HP:0009025)2.69320057
24Hyperlipoproteinemia (HP:0010980)2.68361630
25Complement deficiency (HP:0004431)2.66561542
26Hyperammonemia (HP:0001987)2.61633373
27Hyperglycemia (HP:0003074)2.60064049
28Difficulty running (HP:0009046)2.59642866
29Bundle branch block (HP:0011710)2.58234345
30Abnormality of the intrinsic pathway (HP:0010989)2.55674210
31Centrally nucleated skeletal muscle fibers (HP:0003687)2.54144998
32Dysmetric saccades (HP:0000641)2.53460826
33Hypoalphalipoproteinemia (HP:0003233)2.52808425
34Skin nodule (HP:0200036)2.51059648
35Subaortic stenosis (HP:0001682)2.48970299
36Abnormality of the left ventricular outflow tract (HP:0011103)2.48970299
37Lymphangioma (HP:0100764)2.44370864
38Epidermoid cyst (HP:0200040)2.44243126
39Abnormality of fatty-acid metabolism (HP:0004359)2.44108143
40Cerebral aneurysm (HP:0004944)2.42995532
41Premature rupture of membranes (HP:0001788)2.42805302
42Arterial tortuosity (HP:0005116)2.42709050
43Calf muscle hypertrophy (HP:0008981)2.36053754
44Vertebral arch anomaly (HP:0008438)2.35244800
45Advanced eruption of teeth (HP:0006288)2.29857871
46Abnormality of glutamine family amino acid metabolism (HP:0010902)2.28292279
47Hypolipoproteinemia (HP:0010981)2.27607751
48Hypobetalipoproteinemia (HP:0003563)2.24948180
49Vascular tortuosity (HP:0004948)2.24710807
50Gout (HP:0001997)2.24341381
51Osteolytic defects of the hand bones (HP:0009699)2.23633364
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.23633364
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.22857647
54Myocardial infarction (HP:0001658)2.22387733
55Aneurysm (HP:0002617)2.21749010
56Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.20939778
57Hyperglycinuria (HP:0003108)2.17991615
58Muscle hypertrophy of the lower extremities (HP:0008968)2.17215549
59Abnormality of endocrine pancreas physiology (HP:0012093)2.15572650
60Abnormality of the pancreatic islet cells (HP:0006476)2.15572650
61Syncope (HP:0001279)2.14088681
62Abnormality of purine metabolism (HP:0004352)2.11056007
63Atrioventricular block (HP:0001678)2.10389452
64Papillary thyroid carcinoma (HP:0002895)2.10183943
65Spinal rigidity (HP:0003306)2.09670525
66Abnormality of glycine metabolism (HP:0010895)2.06415423
67Abnormality of serine family amino acid metabolism (HP:0010894)2.06415423
68Termporal pattern (HP:0011008)2.05949288
69Insidious onset (HP:0003587)2.05949288
70Type 1 muscle fiber predominance (HP:0003803)2.05337312
71Lipoatrophy (HP:0100578)2.05210119
72Abnormality of oral frenula (HP:0000190)2.05138158
73EMG: myopathic abnormalities (HP:0003458)2.04917304
74Distal upper limb amyotrophy (HP:0007149)2.03984878
75Upper limb amyotrophy (HP:0009129)2.03984878
76Short nail (HP:0001799)2.02420283
77Macroorchidism (HP:0000053)2.01471279
78Prolonged partial thromboplastin time (HP:0003645)2.01359552
79Distal lower limb amyotrophy (HP:0008944)2.00616597
80Late onset (HP:0003584)1.97969192
81Symptomatic seizures (HP:0011145)1.97006778
82Pancreatic islet-cell hyperplasia (HP:0004510)1.96935167
83Abnormality of sulfur amino acid metabolism (HP:0004339)1.96566160
84Fat malabsorption (HP:0002630)1.95731257
85Shallow orbits (HP:0000586)1.94869483
86Thin bony cortex (HP:0002753)1.94125660
87Hyperacusis (HP:0010780)1.93156805
88Hamartoma of the eye (HP:0010568)1.93103797
89Heart block (HP:0012722)1.91546022
90Hepatocellular carcinoma (HP:0001402)1.91276952
91Abnormality of carpal bone ossification (HP:0006257)1.90376575
92Ventricular arrhythmia (HP:0004308)1.90268383
93Palpitations (HP:0001962)1.89645653
94Abnormality of the Achilles tendon (HP:0005109)1.89592095
95Abnormality of the calf musculature (HP:0001430)1.89399477
96Difficulty climbing stairs (HP:0003551)1.89353911
97Mildly elevated creatine phosphokinase (HP:0008180)1.88678024
98Dilated cardiomyopathy (HP:0001644)1.88138352
99Increased variability in muscle fiber diameter (HP:0003557)1.88051705
100Back pain (HP:0003418)1.87919287
101Abnormality of skeletal muscle fiber size (HP:0012084)1.87903235
102Heterotopia (HP:0002282)1.87842738
103Rhabdomyolysis (HP:0003201)1.87037725
104Progressive external ophthalmoplegia (HP:0000590)1.86890146
105Esophageal varix (HP:0002040)1.86753221
106Abnormality of complement system (HP:0005339)1.86502498
107Distal lower limb muscle weakness (HP:0009053)1.86213433
108Broad metatarsal (HP:0001783)1.85933231
109Abnormality of the salivary glands (HP:0010286)1.85486108
110Hypercholesterolemia (HP:0003124)1.84008773
111Atrial fibrillation (HP:0005110)1.83477316
112Tetraparesis (HP:0002273)1.83199155
113Abnormal atrioventricular conduction (HP:0005150)1.82191313
114Conjunctival hamartoma (HP:0100780)1.82127012
115Nemaline bodies (HP:0003798)1.82122702
116Hand muscle atrophy (HP:0009130)1.81899376
117Abnormal gallbladder morphology (HP:0012437)1.81258253
118Hypoplastic ischia (HP:0003175)1.81094154
119Wormian bones (HP:0002645)1.80810415
120Conjugated hyperbilirubinemia (HP:0002908)1.80136559
121Lip pit (HP:0100267)1.79667633
122Long toe (HP:0010511)1.79620935
123Cholelithiasis (HP:0001081)1.79465504
124Cholecystitis (HP:0001082)1.79420656
125Abnormal gallbladder physiology (HP:0012438)1.79420656
126Muscle fiber inclusion bodies (HP:0100299)1.78503085
127Fragile skin (HP:0001030)1.78395794
128Hyperkalemia (HP:0002153)1.78176106
129Atrophic scars (HP:0001075)1.77980982
130Vertebral compression fractures (HP:0002953)1.77701989
131Abnormality of the ischium (HP:0003174)1.77541254
132Abnormality of the fingertips (HP:0001211)1.77513643
133Mitral stenosis (HP:0001718)1.76685162
134Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76237488
135Mitral valve prolapse (HP:0001634)1.76232472
136Sparse lateral eyebrow (HP:0005338)1.75742166
137Protuberant abdomen (HP:0001538)1.75166318
138Cubitus valgus (HP:0002967)1.75105185
139Hemorrhage of the eye (HP:0011885)1.74276119
140Hyperbilirubinemia (HP:0002904)1.73088379
141Polycythemia (HP:0001901)1.73066001
142Neonatal death (HP:0003811)1.70979348
143Insulin-resistant diabetes mellitus (HP:0000831)1.69977350
144Protrusio acetabuli (HP:0003179)1.69934639
145Turricephaly (HP:0000262)1.69605180
146Hyperglycinemia (HP:0002154)1.69510989
147Relative macrocephaly (HP:0004482)1.69410123
148Overgrowth (HP:0001548)1.69175949
149Abnormality of the gastric mucosa (HP:0004295)1.67077724
150Hammertoe (HP:0001765)1.66798050
151Abnormality of the distal phalanges of the toes (HP:0010182)1.66727611
152Abnormal ossification of hand bones (HP:0005921)1.65822250
153Abnormal foot bone ossification (HP:0010675)1.65505672
154Subacute progressive viral hepatitis (HP:0006572)1.64540116
155Asymmetry of the thorax (HP:0001555)1.64438423
156Obstructive sleep apnea (HP:0002870)1.63756477
157Achilles tendon contracture (HP:0001771)1.63251913
158Increased nuchal translucency (HP:0010880)1.61357003
159Disproportionate tall stature (HP:0001519)1.60387460
160Overlapping toe (HP:0001845)1.60068038
161Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59766641
162Progressive hearing impairment (HP:0001730)1.59755554
163Deep philtrum (HP:0002002)1.59076148
164Trismus (HP:0000211)1.58458273
165Curly hair (HP:0002212)1.58276028
166Cerebral inclusion bodies (HP:0100314)1.57829228
167Abnormal tarsal ossification (HP:0008369)1.56742914
168Broad face (HP:0000283)1.56014296
169Breech presentation (HP:0001623)1.55051666
170Fatigue (HP:0012378)1.54856760
171Abnormality of the distal phalanx of the thumb (HP:0009617)1.53392932
172Long palpebral fissure (HP:0000637)1.53314351
173Progressive muscle weakness (HP:0003323)1.51699592
174Natal tooth (HP:0000695)1.51625070
175Abnormality of the calcaneus (HP:0008364)1.51395044
176Blue sclerae (HP:0000592)1.51142528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.28701061
2PKN23.58950420
3ERN13.27688954
4TTN3.25969744
5PRPF4B2.42099387
6SIK12.29412094
7LATS22.26914453
8RIPK12.25607703
9MAP3K132.21832536
10SMG12.19104968
11EPHA22.06035120
12EPHB12.05366395
13PTK62.04231303
14STK242.03576259
15TAOK32.01550771
16LATS11.94995706
17BCKDK1.89953547
18INSRR1.83902540
19MAP3K91.81610709
20DMPK1.77189661
21FGFR41.72350539
22FRK1.68576768
23MAP3K101.68266959
24PDGFRA1.61047400
25EEF2K1.61007161
26LMTK21.59791876
27IRAK31.55308832
28BRD41.52762955
29PNCK1.49964995
30PDK41.48633151
31PDK31.48633151
32PRKD31.38342707
33CAMK1G1.35588950
34CAMK1D1.34111355
35MAP3K71.33255747
36MAP3K21.33147939
37TSSK61.22334725
38TTK1.21533971
39AKT31.18921310
40JAK11.18262891
41PHKG11.17160217
42PHKG21.17160217
43EIF2AK11.16386057
44MAP3K141.15669947
45RET1.14168980
46PRKCH1.11853151
47PAK31.09091067
48FLT31.08936005
49WNK41.05722982
50KSR21.05706379
51ICK1.05074272
52FGFR21.04847488
53SCYL21.02973510
54ARAF1.01913647
55LRRK21.01346015
56PTK21.00049689
57OBSCN0.99162257
58FGFR30.93731815
59PDGFRB0.92971023
60PAK40.92261380
61MET0.91806262
62KSR10.89814790
63WNK10.88212924
64JAK20.86748781
65STK38L0.85927993
66CDK90.85511628
67MTOR0.84981905
68MELK0.84102786
69PDPK10.83453103
70CDK120.82105374
71MAP3K10.81818742
72EIF2AK30.81650833
73BMX0.80123022
74MAP3K80.79398591
75* PRKD10.78645008
76NTRK10.77125425
77MAP2K30.76094068
78RPS6KB20.75739833
79SGK30.73928903
80PDK10.73644231
81NEK60.72395221
82PRKAA20.70984355
83PRKAA10.70378107
84MOS0.70176956
85PDK20.70094700
86BRAF0.68692876
87RAF10.68511364
88TGFBR20.67465496
89ALK0.67123321
90TYK20.66836517
91PIK3CA0.66599907
92CAMKK10.65057643
93EPHA30.64978117
94CDK70.64890168
95CDC42BPA0.64728426
96HIPK20.62909047
97MAP3K30.62322725
98FER0.62005522
99TRPM70.61444218
100PAK20.58101044
101STK30.56442707
102STK380.56247659
103MAPK110.56156311
104TAOK10.55982797
105CHEK10.55437097
106MST1R0.53788106
107NEK90.53366299
108CDK60.51926464
109PIK3CG0.51525759
110YES10.51482009
111ERBB40.51243160
112MAP2K10.51171567
113NEK10.50785502
114AKT20.50776931
115GSK3A0.50731754
116STK390.49738563
117DDR20.48972355
118PAK60.47000715
119MYLK0.46127885
120STK100.44597593
121ITK0.44137399
122TAOK20.42829453
123ROCK10.40571847
124MARK20.39891360
125JAK30.39711853
126PTK2B0.39592149
127DYRK1B0.39375993
128CDK40.38529489
129MST40.38085859
130TBK10.37445072
131MAPK100.37360905
132MAPKAPK30.37053952
133CSK0.36685422
134STK110.36410783
135ILK0.35864138
136RPS6KA20.35827306
137PRKACG0.34557536
138MAP4K10.34431816
139RPS6KB10.34125449
140MAP3K60.30719404
141PASK0.28080676

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.69763093
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.07567654
3Fatty acid degradation_Homo sapiens_hsa000712.55774053
4Arginine biosynthesis_Homo sapiens_hsa002202.35790072
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.32622834
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.22623097
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16725799
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.09800839
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09658188
10Propanoate metabolism_Homo sapiens_hsa006402.07600252
11Tryptophan metabolism_Homo sapiens_hsa003801.94540990
12Thyroid cancer_Homo sapiens_hsa052161.93299920
13Fatty acid metabolism_Homo sapiens_hsa012121.89132502
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84072929
15Butanoate metabolism_Homo sapiens_hsa006501.75795595
16PPAR signaling pathway_Homo sapiens_hsa033201.73076242
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.65302121
18Sulfur metabolism_Homo sapiens_hsa009201.53112003
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49845558
20Pancreatic cancer_Homo sapiens_hsa052121.49812359
21Bile secretion_Homo sapiens_hsa049761.49218028
22Endometrial cancer_Homo sapiens_hsa052131.48470153
23Starch and sucrose metabolism_Homo sapiens_hsa005001.45481621
24Complement and coagulation cascades_Homo sapiens_hsa046101.45095652
25Acute myeloid leukemia_Homo sapiens_hsa052211.42647594
26Prostate cancer_Homo sapiens_hsa052151.41117563
27Insulin resistance_Homo sapiens_hsa049311.31643377
28Lysine degradation_Homo sapiens_hsa003101.30118686
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29017992
30Fat digestion and absorption_Homo sapiens_hsa049751.27348077
31Carbon metabolism_Homo sapiens_hsa012001.24734616
32Small cell lung cancer_Homo sapiens_hsa052221.20289269
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19245803
34Pyruvate metabolism_Homo sapiens_hsa006201.19210343
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18786764
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17840724
37Pentose phosphate pathway_Homo sapiens_hsa000301.16348071
38Caffeine metabolism_Homo sapiens_hsa002321.16047879
39ErbB signaling pathway_Homo sapiens_hsa040121.15985018
40Bladder cancer_Homo sapiens_hsa052191.14989058
41ABC transporters_Homo sapiens_hsa020101.14234664
42Other glycan degradation_Homo sapiens_hsa005111.11108017
43Fructose and mannose metabolism_Homo sapiens_hsa000511.08850189
44Peroxisome_Homo sapiens_hsa041461.08427574
45beta-Alanine metabolism_Homo sapiens_hsa004101.07237712
46MicroRNAs in cancer_Homo sapiens_hsa052061.07046049
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05920329
48Adipocytokine signaling pathway_Homo sapiens_hsa049201.04343111
49Type II diabetes mellitus_Homo sapiens_hsa049301.01441344
50Prolactin signaling pathway_Homo sapiens_hsa049171.00625531
51Selenocompound metabolism_Homo sapiens_hsa004501.00574711
52Dilated cardiomyopathy_Homo sapiens_hsa054141.00468636
53Hepatitis C_Homo sapiens_hsa051600.98531507
54Glioma_Homo sapiens_hsa052140.97756152
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.97561480
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95980523
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95289447
58Inositol phosphate metabolism_Homo sapiens_hsa005620.93214203
59Histidine metabolism_Homo sapiens_hsa003400.88902926
60mRNA surveillance pathway_Homo sapiens_hsa030150.88270978
61Circadian rhythm_Homo sapiens_hsa047100.87767233
62Staphylococcus aureus infection_Homo sapiens_hsa051500.86906104
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86775344
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86694597
65Glucagon signaling pathway_Homo sapiens_hsa049220.86429226
66Tight junction_Homo sapiens_hsa045300.85804498
67Fatty acid biosynthesis_Homo sapiens_hsa000610.83425795
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83115264
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83019745
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82331190
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.81389167
72Notch signaling pathway_Homo sapiens_hsa043300.80187312
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78187324
74Biosynthesis of amino acids_Homo sapiens_hsa012300.76973730
75Cell cycle_Homo sapiens_hsa041100.76837617
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74738759
77FoxO signaling pathway_Homo sapiens_hsa040680.74398220
78AMPK signaling pathway_Homo sapiens_hsa041520.74394672
79Insulin signaling pathway_Homo sapiens_hsa049100.74168804
80Phenylalanine metabolism_Homo sapiens_hsa003600.73883204
81Choline metabolism in cancer_Homo sapiens_hsa052310.73117439
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72286350
83Glycerolipid metabolism_Homo sapiens_hsa005610.70234664
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69562436
85Focal adhesion_Homo sapiens_hsa045100.69465133
86Colorectal cancer_Homo sapiens_hsa052100.69005404
87Amoebiasis_Homo sapiens_hsa051460.68367096
88GnRH signaling pathway_Homo sapiens_hsa049120.67545772
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67072185
90HIF-1 signaling pathway_Homo sapiens_hsa040660.64678772
91Vitamin B6 metabolism_Homo sapiens_hsa007500.64274373
92B cell receptor signaling pathway_Homo sapiens_hsa046620.63802065
93Chemical carcinogenesis_Homo sapiens_hsa052040.63787329
94Sphingolipid metabolism_Homo sapiens_hsa006000.63405280
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62722205
96Dorso-ventral axis formation_Homo sapiens_hsa043200.62704433
97Hepatitis B_Homo sapiens_hsa051610.62414337
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62108856
99Fatty acid elongation_Homo sapiens_hsa000620.60106175
100mTOR signaling pathway_Homo sapiens_hsa041500.58454214
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58392482
102Thyroid hormone synthesis_Homo sapiens_hsa049180.56447201
103Influenza A_Homo sapiens_hsa051640.56405042
104TNF signaling pathway_Homo sapiens_hsa046680.55993612
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55636339
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54262031
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.53040845
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.52160610
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52122934
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51010746
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50734913
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50453204
113Insulin secretion_Homo sapiens_hsa049110.49549514
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49216668
115Arginine and proline metabolism_Homo sapiens_hsa003300.49132100
116Renin-angiotensin system_Homo sapiens_hsa046140.49064439
117Long-term potentiation_Homo sapiens_hsa047200.48248525
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.47820448
119ECM-receptor interaction_Homo sapiens_hsa045120.47259300
120Prion diseases_Homo sapiens_hsa050200.46279855
121N-Glycan biosynthesis_Homo sapiens_hsa005100.45630621
122Protein digestion and absorption_Homo sapiens_hsa049740.45366346
123Adherens junction_Homo sapiens_hsa045200.43654919
124Tyrosine metabolism_Homo sapiens_hsa003500.42075837
125Chronic myeloid leukemia_Homo sapiens_hsa052200.41704910
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41524990
127Proteoglycans in cancer_Homo sapiens_hsa052050.40398896
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.38235508
129Renal cell carcinoma_Homo sapiens_hsa052110.38025621
130Pancreatic secretion_Homo sapiens_hsa049720.37796554
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37683443
132Galactose metabolism_Homo sapiens_hsa000520.37412013
133Estrogen signaling pathway_Homo sapiens_hsa049150.37395052
134Retinol metabolism_Homo sapiens_hsa008300.36257739
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34223554
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33708468
137Viral myocarditis_Homo sapiens_hsa054160.33590513
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.33193025
139Platelet activation_Homo sapiens_hsa046110.32015844
140Gastric acid secretion_Homo sapiens_hsa049710.30057583
141Lysosome_Homo sapiens_hsa041420.29896815
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28526296
143Non-small cell lung cancer_Homo sapiens_hsa052230.28466951
144VEGF signaling pathway_Homo sapiens_hsa043700.28433379
145Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28388246
146Cysteine and methionine metabolism_Homo sapiens_hsa002700.28230883

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