OSBPL10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)6.46861281
2acrosome reaction (GO:0007340)6.08948917
3fusion of sperm to egg plasma membrane (GO:0007342)5.84028448
4cell wall macromolecule catabolic process (GO:0016998)5.66063939
5cell wall macromolecule metabolic process (GO:0044036)5.66063939
6regulation of cilium movement (GO:0003352)5.38334604
7acrosome assembly (GO:0001675)5.30465118
8sperm-egg recognition (GO:0035036)5.16152731
9spermatid development (GO:0007286)4.85940554
10piRNA metabolic process (GO:0034587)4.85329528
11binding of sperm to zona pellucida (GO:0007339)4.84604715
12multicellular organism reproduction (GO:0032504)4.83101842
13regulation of acrosome reaction (GO:0060046)4.81390096
14epithelial cilium movement (GO:0003351)4.72230536
15plasma membrane fusion (GO:0045026)4.63817707
16cell-cell recognition (GO:0009988)4.51494912
17synaptonemal complex organization (GO:0070193)4.46552967
18synaptonemal complex assembly (GO:0007130)4.42900889
19motile cilium assembly (GO:0044458)4.41574392
20negative regulation of inclusion body assembly (GO:0090084)4.36862277
21regulation of mesoderm development (GO:2000380)4.34619539
22oocyte development (GO:0048599)4.31710469
23reproduction (GO:0000003)4.29989035
24axonemal dynein complex assembly (GO:0070286)4.29495455
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.24168696
26nuclear pore organization (GO:0006999)4.22902390
27male meiosis (GO:0007140)4.17342923
28calcium ion-dependent exocytosis (GO:0017156)4.14033457
29regulation of microtubule-based movement (GO:0060632)4.11299087
30synaptic vesicle maturation (GO:0016188)4.07200257
31regulation of short-term neuronal synaptic plasticity (GO:0048172)4.02117737
32nuclear pore complex assembly (GO:0051292)4.00345022
33regulation of female gonad development (GO:2000194)3.95679866
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.93539663
35regulation of gene silencing by RNA (GO:0060966)3.86195398
36regulation of posttranscriptional gene silencing (GO:0060147)3.86195398
37regulation of gene silencing by miRNA (GO:0060964)3.86195398
38regulation of histone H3-K9 methylation (GO:0051570)3.81349055
39cilium movement (GO:0003341)3.80964966
40desmosome organization (GO:0002934)3.79163933
41spermatogenesis (GO:0007283)3.75257651
42male gamete generation (GO:0048232)3.73928572
43DNA replication-dependent nucleosome assembly (GO:0006335)3.71470356
44DNA replication-dependent nucleosome organization (GO:0034723)3.71470356
45microtubule severing (GO:0051013)3.63221728
46synaptic vesicle docking involved in exocytosis (GO:0016081)3.59474873
47regulation of inclusion body assembly (GO:0090083)3.58657886
48replicative senescence (GO:0090399)3.57364514
49bundle of His cell to Purkinje myocyte communication (GO:0086069)3.53897346
50proline transport (GO:0015824)3.53457834
51gamete generation (GO:0007276)3.50684711
52cell migration in hindbrain (GO:0021535)3.50637769
53glutamate secretion (GO:0014047)3.50410026
54cilium or flagellum-dependent cell motility (GO:0001539)3.44526875
55RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.40317633
56protein polyglutamylation (GO:0018095)3.40119981
57organic cation transport (GO:0015695)3.31334986
58positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.26564529
59positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.26564529
60positive regulation of mitotic sister chromatid separation (GO:1901970)3.26564529
61dorsal/ventral axis specification (GO:0009950)3.26347549
62negative regulation of keratinocyte proliferation (GO:0010839)3.25726101
63fertilization (GO:0009566)3.23655000
64single fertilization (GO:0007338)3.21689835
65labyrinthine layer development (GO:0060711)3.20308647
66sperm capacitation (GO:0048240)3.19651640
67layer formation in cerebral cortex (GO:0021819)3.19420698
68glomerular visceral epithelial cell development (GO:0072015)3.19412737
69nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.18280326
70histone-serine phosphorylation (GO:0035404)3.17964474
71germ cell development (GO:0007281)3.13841514
72hemidesmosome assembly (GO:0031581)3.13502616
73microtubule depolymerization (GO:0007019)3.13238779
74regulation of DNA endoreduplication (GO:0032875)3.12282361
75positive regulation of chromosome segregation (GO:0051984)3.12200621
76embryonic foregut morphogenesis (GO:0048617)3.11929741
77ventricular system development (GO:0021591)3.08822304
78synaptic vesicle exocytosis (GO:0016079)3.07586967
79regulation of gene silencing (GO:0060968)3.07560745
80somatic hypermutation of immunoglobulin genes (GO:0016446)3.06394667
81somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06394667
82artery development (GO:0060840)3.06027246
83regulation of synaptic vesicle exocytosis (GO:2000300)3.05645002
84chromosome condensation (GO:0030261)3.05468708
85protein K11-linked deubiquitination (GO:0035871)3.04641032
86locomotory exploration behavior (GO:0035641)3.04592742
87regulation of meiosis I (GO:0060631)3.01485377
88cellular process involved in reproduction in multicellular organism (GO:0022412)2.98878529
89establishment of apical/basal cell polarity (GO:0035089)2.97752675
90DNA methylation involved in gamete generation (GO:0043046)2.96909386
91regulation of centriole replication (GO:0046599)2.95489456
92UDP-N-acetylglucosamine metabolic process (GO:0006047)2.95437502
93negative regulation of organelle assembly (GO:1902116)2.91341948
94establishment or maintenance of monopolar cell polarity (GO:0061339)2.91063018
95establishment of monopolar cell polarity (GO:0061162)2.91063018
96meiotic cell cycle (GO:0051321)2.88848807
97cellular potassium ion homeostasis (GO:0030007)2.88259626
98CENP-A containing nucleosome assembly (GO:0034080)2.87875798
99negative regulation of histone methylation (GO:0031061)2.87854653
100regulation of DNA methylation (GO:0044030)2.85566177
101negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.85208617
102sodium ion export (GO:0071436)2.83603044
103paraxial mesoderm development (GO:0048339)2.81902420
104multicellular organismal reproductive process (GO:0048609)2.80080191
105vocalization behavior (GO:0071625)2.79730019
106pore complex assembly (GO:0046931)2.79726516
107histone exchange (GO:0043486)2.79175126
108protein localization to kinetochore (GO:0034501)2.78890672
109heterochromatin organization (GO:0070828)2.77786812
110DNA packaging (GO:0006323)2.76648535
111protein K48-linked deubiquitination (GO:0071108)2.76519363
112neuromuscular process controlling posture (GO:0050884)2.76263058
113membrane depolarization during action potential (GO:0086010)2.75845451
114positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.74577107
115gene silencing by RNA (GO:0031047)2.74297186
116synaptic vesicle endocytosis (GO:0048488)2.73616831
117lymphangiogenesis (GO:0001946)2.71245376
118meiotic nuclear division (GO:0007126)2.67568446
119regulation of synaptic vesicle transport (GO:1902803)2.67463552
120regulation of chromatin silencing (GO:0031935)2.65984041
121glomerular epithelial cell development (GO:0072310)2.64676185
122ectoderm development (GO:0007398)2.63981602
123chromatin remodeling at centromere (GO:0031055)2.63521857
124regulation of centrosome cycle (GO:0046605)2.63510817
125replication fork processing (GO:0031297)2.62790611
126response to UV-C (GO:0010225)2.62230687
127synapsis (GO:0007129)2.61255021
128regulation of keratinocyte proliferation (GO:0010837)2.60255213
129chromosome organization involved in meiosis (GO:0070192)2.56722458
130cell recognition (GO:0008037)2.55857082
131retinal cone cell development (GO:0046549)2.55611734
132glycolytic process (GO:0006096)2.54968202
133somatic recombination of immunoglobulin gene segments (GO:0016447)2.54047437
134protein kinase C signaling (GO:0070528)2.53001920
135genitalia morphogenesis (GO:0035112)2.52542437
136lung-associated mesenchyme development (GO:0060484)2.51281586
137cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.51136919
138left/right pattern formation (GO:0060972)2.51106889
139cytoskeletal anchoring at plasma membrane (GO:0007016)2.50723996
140neuromuscular process controlling balance (GO:0050885)2.50549850
141DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.50153374
142female gamete generation (GO:0007292)2.50049448
143pre-miRNA processing (GO:0031054)2.48932062
144regulation of hippo signaling (GO:0035330)2.48359692
145neurotransmitter secretion (GO:0007269)2.45482222
146regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.44519380
147regulation of nuclear cell cycle DNA replication (GO:0033262)2.44263311
148sexual reproduction (GO:0019953)2.44094210
149male meiosis I (GO:0007141)2.43965466
150negative regulation of cardiac muscle tissue development (GO:0055026)2.43362849
151organ formation (GO:0048645)2.43085320
152seminiferous tubule development (GO:0072520)2.42575426
153somatic diversification of immunoglobulins (GO:0016445)2.42297196
154negative regulation of gene silencing (GO:0060969)2.41689784
155protein K63-linked deubiquitination (GO:0070536)2.39979351
156regulation of establishment of cell polarity (GO:2000114)2.39549694
157regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.38716681
158snRNA transcription (GO:0009301)2.38532851
159regulation of NFAT protein import into nucleus (GO:0051532)2.37396093
160negative regulation of hormone biosynthetic process (GO:0032353)2.37394343
161negative regulation of hormone metabolic process (GO:0032351)2.37394343
162regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.37348407
163regulation of phospholipid biosynthetic process (GO:0071071)2.37036852
164somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.36967095
165somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.36967095
166isotype switching (GO:0045190)2.36967095
167glycerol ether metabolic process (GO:0006662)2.36175249
168regulation of neuronal synaptic plasticity (GO:0048168)2.34645559
169regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.34585237
170negative regulation of DNA repair (GO:0045738)2.34213507
171transcription elongation from RNA polymerase I promoter (GO:0006362)2.33959225
172protein localization to synapse (GO:0035418)2.33658724
173cell migration involved in gastrulation (GO:0042074)2.31917589
174CDP-diacylglycerol biosynthetic process (GO:0016024)2.30534187
175DNA damage response, signal transduction resulting in transcription (GO:0042772)2.29929402
176mitotic metaphase plate congression (GO:0007080)2.29894968
177regulation of clathrin-mediated endocytosis (GO:2000369)2.29707824
178intracellular estrogen receptor signaling pathway (GO:0030520)2.29089804
179gap junction assembly (GO:0016264)2.29024335
180hippo signaling (GO:0035329)2.28776218
181protein localization to chromosome, centromeric region (GO:0071459)2.28509857
182microtubule-based movement (GO:0007018)2.28117500
183maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.27612167
184interferon-gamma secretion (GO:0072643)2.26740597
185multicellular organismal development (GO:0007275)2.26407192
186anterior/posterior axis specification, embryo (GO:0008595)2.25890973
187regulation of establishment or maintenance of cell polarity (GO:0032878)2.25828014
188regulation of cAMP-dependent protein kinase activity (GO:2000479)2.25735313
189CDP-diacylglycerol metabolic process (GO:0046341)2.24400895

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.00030915
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.66737743
3EZH2_22144423_ChIP-Seq_EOC_Human3.95399610
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.92981829
5E2F7_22180533_ChIP-Seq_HELA_Human3.37337306
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.83107737
7GBX2_23144817_ChIP-Seq_PC3_Human2.64267792
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.57948989
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.46298318
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.45477552
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39068092
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.27946045
13REST_21632747_ChIP-Seq_MESCs_Mouse2.25049105
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.11104079
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.08757178
16* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.08527071
17RCOR3_21632747_ChIP-Seq_MESCs_Mouse2.06901945
18NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.02903938
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02686599
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.01648566
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.98735256
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97554836
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96928766
24* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.92658570
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85868393
26GATA1_26923725_Chip-Seq_HPCs_Mouse1.85781471
27TP53_16413492_ChIP-PET_HCT116_Human1.85354876
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.84577905
29FUS_26573619_Chip-Seq_HEK293_Human1.76679931
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73228558
31FOXM1_26456572_ChIP-Seq_MCF-7_Human1.71749269
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.71531836
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.69803575
34AHR_22903824_ChIP-Seq_MCF-7_Human1.69064931
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.68172734
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.68172734
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.68172734
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65498348
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.63901295
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59586955
41P300_19829295_ChIP-Seq_ESCs_Human1.59561194
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58416578
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56959922
44* STAT3_23295773_ChIP-Seq_U87_Human1.54831489
45ZNF263_19887448_ChIP-Seq_K562_Human1.54488913
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52829966
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51155944
48CJUN_26792858_Chip-Seq_BT549_Human1.47947917
49SMAD4_21799915_ChIP-Seq_A2780_Human1.47803561
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47302356
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46865533
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45917795
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.44673961
54* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44581267
55AR_21909140_ChIP-Seq_LNCAP_Human1.44153718
56PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.43849909
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42159864
58NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.41694490
59DROSHA_22980978_ChIP-Seq_HELA_Human1.41183112
60EWS_26573619_Chip-Seq_HEK293_Human1.40869979
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39598193
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39389817
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38017832
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.37093062
65KDM2B_26808549_Chip-Seq_K562_Human1.36628715
66ELK4_26923725_Chip-Seq_MESODERM_Mouse1.36388331
67* TCF4_23295773_ChIP-Seq_U87_Human1.36250632
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.35426270
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.34100370
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33788693
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32929697
72TET1_21490601_ChIP-Seq_MESCs_Mouse1.32908069
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.32280225
74POU5F1_16518401_ChIP-PET_MESCs_Mouse1.30580805
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29979239
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29341483
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28641273
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.28203954
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27587564
80SMC4_20622854_ChIP-Seq_HELA_Human1.27086800
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26932441
82FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25738712
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25347921
84CTCF_27219007_Chip-Seq_Bcells_Human1.24569143
85BRD4_25478319_ChIP-Seq_HGPS_Human1.23577558
86ZNF274_21170338_ChIP-Seq_K562_Hela1.22052735
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21828014
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21828014
89EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21029965
90ESR1_20079471_ChIP-ChIP_T-47D_Human1.20845114
91* E2F1_21310950_ChIP-Seq_MCF-7_Human1.20261619
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19876073
93* AR_25329375_ChIP-Seq_VCAP_Human1.19755583
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19593663
95PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19012132
96TP53_18474530_ChIP-ChIP_U2OS_Human1.18902524
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18751377
98RNF2_27304074_Chip-Seq_ESCs_Mouse1.18567372
99* ERG_21242973_ChIP-ChIP_JURKAT_Human1.18400433
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18246687
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17912093
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17717220
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17593517
104* CDX2_22108803_ChIP-Seq_LS180_Human1.15890243
105TP63_23658742_ChIP-Seq_EP156T_Human1.15826084
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15617632
107TAF15_26573619_Chip-Seq_HEK293_Human1.15407688
108* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15239340
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14544270
110CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13752895
111OCT4_19829295_ChIP-Seq_ESCs_Human1.13493846
112* EP300_21415370_ChIP-Seq_HL-1_Mouse1.13072006
113VDR_22108803_ChIP-Seq_LS180_Human1.12452664
114* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12217003
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11988358
116CBP_20019798_ChIP-Seq_JUKART_Human1.11988358
117SMAD3_21741376_ChIP-Seq_EPCs_Human1.10173880
118LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09530250
119TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08947295
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08879308
121TET1_21451524_ChIP-Seq_MESCs_Mouse1.08353347
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08145674
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07875354
124WDR5_24793694_ChIP-Seq_LNCAP_Human1.06237078
125CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06145098
126MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05825723
127TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.04939534
128SMAD_19615063_ChIP-ChIP_OVARY_Human1.04650815
129LXR_22292898_ChIP-Seq_THP-1_Human1.03662720
130SMAD4_21741376_ChIP-Seq_EPCs_Human1.03526743
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03289005
132PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02944016
133TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02444022
134STAT3_18555785_ChIP-Seq_MESCs_Mouse1.02405348
135TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02344582
136TP63_19390658_ChIP-ChIP_HaCaT_Human1.02272356
137IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02176172
138SMAD3_21741376_ChIP-Seq_HESCs_Human1.01831843
139ER_23166858_ChIP-Seq_MCF-7_Human1.01454987
140EZH2_27294783_Chip-Seq_ESCs_Mouse1.01302655
141* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01104895
142SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00821809
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00284305
144ESR1_21235772_ChIP-Seq_MCF-7_Human0.99960330
145TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99877089
146NANOG_18692474_ChIP-Seq_MESCs_Mouse0.99580295
147RNF2_27304074_Chip-Seq_NSC_Mouse0.99054894
148ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99023748
149* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99007818
150EZH2_27294783_Chip-Seq_NPCs_Mouse0.98642608
151STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97822235
152CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97633701
153KLF4_19829295_ChIP-Seq_ESCs_Human0.97511612
154NANOG_16518401_ChIP-PET_MESCs_Mouse0.97462963
155RING1B_27294783_Chip-Seq_NPCs_Mouse0.96545197
156MYC_27129775_Chip-Seq_CORNEA_Mouse0.96409696
157TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96074848
158* TP63_22573176_ChIP-Seq_HFKS_Human0.96065718
159FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95721050
160TCF4_22108803_ChIP-Seq_LS180_Human0.95249977
161MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94130159
162FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94103684
163RING1B_27294783_Chip-Seq_ESCs_Mouse0.93984817
164SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93947833
165JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93675548
166TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93318292
167TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92503401
168FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92488549
169NFE2_27457419_Chip-Seq_LIVER_Mouse0.92078705
170IGF1R_20145208_ChIP-Seq_DFB_Human0.91982949
171SPI1_26923725_Chip-Seq_HPCs_Mouse0.91720359
172SMAD3_21741376_ChIP-Seq_ESCs_Human0.90983536
173RUNX1_27514584_Chip-Seq_MCF-7_Human0.90901398
174TCF4_18268006_ChIP-ChIP_LS174T_Human0.90571557
175SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.90457136
176TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90126803
177* RUNX2_22187159_ChIP-Seq_PCA_Human0.89849495
178GATA4_25053715_ChIP-Seq_YYC3_Human0.89540272
179* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88582454
180TP53_23651856_ChIP-Seq_MEFs_Mouse0.88023818
181SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87865543
182* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87719987
183NANOG_21062744_ChIP-ChIP_HESCs_Human0.87601655
184P68_20966046_ChIP-Seq_HELA_Human0.84213280
185RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83895889
186CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83325098
187POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.83237930
188* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82252524
189CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81325365
190EZH2_18974828_ChIP-Seq_MESCs_Mouse0.81280610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.87498568
2MP0004859_abnormal_synaptic_plasticity3.89364874
3MP0003718_maternal_effect3.86089748
4MP0002653_abnormal_ependyma_morphology3.19215316
5MP0010678_abnormal_skin_adnexa3.16017126
6MP0008877_abnormal_DNA_methylation3.04633411
7MP0003698_abnormal_male_reproductive2.95030507
8MP0000383_abnormal_hair_follicle2.91662626
9MP0002254_reproductive_system_inflammat2.80986899
10MP0008057_abnormal_DNA_replication2.77187488
11MP0004270_analgesia2.75502855
12MP0001929_abnormal_gametogenesis2.70597984
13MP0003941_abnormal_skin_development2.52942972
14MP0003950_abnormal_plasma_membrane2.40907474
15MP0004858_abnormal_nervous_system2.40281163
16MP0003283_abnormal_digestive_organ2.30820720
17MP0003693_abnormal_embryo_hatching2.21578251
18MP0003635_abnormal_synaptic_transmissio2.18110911
19MP0004233_abnormal_muscle_weight2.12102891
20MP0010094_abnormal_chromosome_stability2.11278543
21MP0009046_muscle_twitch2.05196267
22MP0002138_abnormal_hepatobiliary_system2.03373599
23MP0002063_abnormal_learning/memory/cond1.85903465
24MP0002161_abnormal_fertility/fecundity1.85324667
25MP0004272_abnormal_basement_membrane1.85223754
26MP0005395_other_phenotype1.84981857
27MP0002734_abnormal_mechanical_nocicepti1.82035278
28MP0001968_abnormal_touch/_nociception1.80407994
29MP0002210_abnormal_sex_determination1.77812346
30MP0005623_abnormal_meninges_morphology1.75937228
31MP0003937_abnormal_limbs/digits/tail_de1.75807331
32MP0003787_abnormal_imprinting1.74629243
33MP0002102_abnormal_ear_morphology1.73750279
34MP0000613_abnormal_salivary_gland1.73558308
35MP0004264_abnormal_extraembryonic_tissu1.72524451
36MP0005275_abnormal_skin_tensile1.67207136
37MP0009697_abnormal_copulation1.64760355
38MP0003077_abnormal_cell_cycle1.60682150
39MP0009053_abnormal_anal_canal1.59708967
40MP0001661_extended_life_span1.58332505
41MP0000579_abnormal_nail_morphology1.57776576
42MP0001145_abnormal_male_reproductive1.56876248
43MP0000427_abnormal_hair_cycle1.55362472
44MP0002733_abnormal_thermal_nociception1.51809479
45MP0002572_abnormal_emotion/affect_behav1.51368048
46MP0010234_abnormal_vibrissa_follicle1.48533830
47MP0003123_paternal_imprinting1.45399921
48MP0000653_abnormal_sex_gland1.42073996
49MP0002909_abnormal_adrenal_gland1.41995895
50MP0010368_abnormal_lymphatic_system1.40708792
51MP0008058_abnormal_DNA_repair1.39550932
52MP0004811_abnormal_neuron_physiology1.38388884
53MP0009745_abnormal_behavioral_response1.35684556
54MP0002736_abnormal_nociception_after1.35408623
55MP0005171_absent_coat_pigmentation1.34544869
56MP0002064_seizures1.34033090
57MP0000534_abnormal_ureter_morphology1.31357640
58MP0003880_abnormal_central_pattern1.30023356
59MP0001293_anophthalmia1.29749242
60MP0002735_abnormal_chemical_nociception1.29595998
61MP0003183_abnormal_peptide_metabolism1.29532516
62MP0003119_abnormal_digestive_system1.29453423
63MP0000955_abnormal_spinal_cord1.29255312
64MP0000372_irregular_coat_pigmentation1.28037506
65MP0000467_abnormal_esophagus_morphology1.27200329
66MP0000678_abnormal_parathyroid_gland1.25921269
67MP0001970_abnormal_pain_threshold1.25273377
68MP0006292_abnormal_olfactory_placode1.25158969
69MP0001849_ear_inflammation1.22679172
70MP0003890_abnormal_embryonic-extraembry1.19418343
71MP0005423_abnormal_somatic_nervous1.16702003
72MP0010030_abnormal_orbit_morphology1.14863102
73MP0005646_abnormal_pituitary_gland1.14374666
74MP0002272_abnormal_nervous_system1.13289908
75MP0002060_abnormal_skin_morphology1.13285330
76MP0008932_abnormal_embryonic_tissue1.12324937
77MP0000377_abnormal_hair_follicle1.11920573
78MP0005360_urolithiasis1.11171399
79MP0003879_abnormal_hair_cell1.08554630
80MP0003045_fibrosis1.07941574
81MP0005499_abnormal_olfactory_system1.07593210
82MP0005394_taste/olfaction_phenotype1.07593210
83MP0003329_amyloid_beta_deposits1.06843766
84MP0001486_abnormal_startle_reflex1.06768615
85MP0004133_heterotaxia1.05720491
86MP0003646_muscle_fatigue1.04925776
87MP0002084_abnormal_developmental_patter1.02858478
88MP0004043_abnormal_pH_regulation1.01655310
89MP0002822_catalepsy1.01519642
90MP0008961_abnormal_basal_metabolism1.01244129
91MP0010771_integument_phenotype1.01164536
92MP0002184_abnormal_innervation1.00967003
93MP0010307_abnormal_tumor_latency1.00838859
94MP0001440_abnormal_grooming_behavior1.00701271
95MP0005503_abnormal_tendon_morphology1.00343005
96MP0003566_abnormal_cell_adhesion1.00304592
97MP0000013_abnormal_adipose_tissue0.98669360
98MP0005408_hypopigmentation0.98339151
99MP0003984_embryonic_growth_retardation0.98313689
100MP0003861_abnormal_nervous_system0.98289781
101MP0009780_abnormal_chondrocyte_physiolo0.97317608
102MP0000428_abnormal_craniofacial_morphol0.95458464
103MP0002088_abnormal_embryonic_growth/wei0.95441314
104MP0010352_gastrointestinal_tract_polyps0.94128815
105MP0000778_abnormal_nervous_system0.92123683
106MP0002085_abnormal_embryonic_tissue0.91682201
107MP0002152_abnormal_brain_morphology0.91551922
108MP0006072_abnormal_retinal_apoptosis0.91512851
109MP0004885_abnormal_endolymph0.90673512
110MP0002006_tumorigenesis0.89426381
111MP0003705_abnormal_hypodermis_morpholog0.89281548
112MP0000462_abnormal_digestive_system0.89219125
113MP0002098_abnormal_vibrissa_morphology0.89180662
114MP0002697_abnormal_eye_size0.88792763
115MP0001286_abnormal_eye_development0.88575336
116MP0005501_abnormal_skin_physiology0.88558605
117MP0002882_abnormal_neuron_morphology0.88121366
118MP0002233_abnormal_nose_morphology0.88010379
119MP0005076_abnormal_cell_differentiation0.87173173
120MP0003786_premature_aging0.86548206
121MP0003942_abnormal_urinary_system0.86523595
122MP0002067_abnormal_sensory_capabilities0.86189766
123MP0002269_muscular_atrophy0.86118557
124MP0000350_abnormal_cell_proliferation0.85831050
125MP0002160_abnormal_reproductive_system0.85635146
126MP0002796_impaired_skin_barrier0.85445383
127MP0004197_abnormal_fetal_growth/weight/0.84731470
128MP0001348_abnormal_lacrimal_gland0.83138121
129MP0003122_maternal_imprinting0.81378449
130MP0003633_abnormal_nervous_system0.80945698
131MP0002234_abnormal_pharynx_morphology0.80936391
132MP0002557_abnormal_social/conspecific_i0.80091011
133MP0005389_reproductive_system_phenotype0.79882032
134MP0002066_abnormal_motor_capabilities/c0.77494454
135MP0001879_abnormal_lymphatic_vessel0.77022380
136MP0003111_abnormal_nucleus_morphology0.76317493
137MP0003195_calcinosis0.76290081
138MP0003935_abnormal_craniofacial_develop0.76181417
139MP0001666_abnormal_nutrient_absorption0.75921025
140MP0000569_abnormal_digit_pigmentation0.75314234
141MP0000631_abnormal_neuroendocrine_gland0.75011174
142MP0004957_abnormal_blastocyst_morpholog0.74705274
143MP0002111_abnormal_tail_morphology0.74660631
144MP0001672_abnormal_embryogenesis/_devel0.74271960
145MP0005380_embryogenesis_phenotype0.74271960
146MP0000432_abnormal_head_morphology0.73974054
147MP0004134_abnormal_chest_morphology0.73740348
148MP0001216_abnormal_epidermal_layer0.72800794
149MP0005257_abnormal_intraocular_pressure0.72630818
150MP0003943_abnormal_hepatobiliary_system0.72622869
151MP0001730_embryonic_growth_arrest0.72578952
152MP0009278_abnormal_bone_marrow0.72014039
153MP0002108_abnormal_muscle_morphology0.71816498
154MP0008569_lethality_at_weaning0.71745534
155MP0005023_abnormal_wound_healing0.71737441
156MP0008438_abnormal_cutaneous_collagen0.71013784
157MP0002282_abnormal_trachea_morphology0.70876515
158MP0008872_abnormal_physiological_respon0.70427705
159MP0000627_abnormal_mammary_gland0.70223388
160MP0002876_abnormal_thyroid_physiology0.69774022
161MP0003631_nervous_system_phenotype0.69677065
162MP0001697_abnormal_embryo_size0.66696915
163MP0000537_abnormal_urethra_morphology0.66680327
164MP0004145_abnormal_muscle_electrophysio0.65931061
165MP0002249_abnormal_larynx_morphology0.65382894
166MP0000516_abnormal_urinary_system0.65168185
167MP0005367_renal/urinary_system_phenotyp0.65168185
168MP0001501_abnormal_sleep_pattern0.64813488
169MP0000762_abnormal_tongue_morphology0.64586372
170MP0003755_abnormal_palate_morphology0.64360724
171MP0002086_abnormal_extraembryonic_tissu0.63770092
172MP0003699_abnormal_female_reproductive0.63589407

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.28036311
2Absent/shortened dynein arms (HP:0200106)6.28036311
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.06558414
4Male infertility (HP:0003251)4.54742268
5Abnormal respiratory motile cilium morphology (HP:0005938)4.37480704
6Abnormal respiratory epithelium morphology (HP:0012253)4.37480704
7Infertility (HP:0000789)4.31510144
8Abnormal respiratory motile cilium physiology (HP:0012261)4.21963405
9Chronic bronchitis (HP:0004469)4.02872847
10Abnormality of the lower motor neuron (HP:0002366)4.01039185
11Chromsome breakage (HP:0040012)3.82960678
12Rhinitis (HP:0012384)3.77193932
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.76553184
14Abnormality of the nasal septum (HP:0000419)3.60520836
15Myokymia (HP:0002411)3.48013576
16Abnormal ciliary motility (HP:0012262)3.07859102
17Bilateral microphthalmos (HP:0007633)2.89054625
18Visual hallucinations (HP:0002367)2.66109500
19Milia (HP:0001056)2.60307091
20Focal seizures (HP:0007359)2.56790114
21Abnormality of chromosome stability (HP:0003220)2.55334879
22Abnormality of the proximal phalanges of the hand (HP:0009834)2.47975827
23Abnormality of the astrocytes (HP:0100707)2.46259631
24Astrocytoma (HP:0009592)2.46259631
25Focal motor seizures (HP:0011153)2.40189543
26Small intestinal stenosis (HP:0012848)2.39853587
27Duodenal stenosis (HP:0100867)2.39853587
28Nephroblastoma (Wilms tumor) (HP:0002667)2.39682303
29Poikiloderma (HP:0001029)2.39616480
30Embryonal renal neoplasm (HP:0011794)2.39526260
31Abnormality of the ileum (HP:0001549)2.37692939
32Amyotrophic lateral sclerosis (HP:0007354)2.36788916
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.36521900
34Annular pancreas (HP:0001734)2.34953007
35Abnormality of the preputium (HP:0100587)2.34771187
36Cutaneous melanoma (HP:0012056)2.34607341
37Morphological abnormality of the middle ear (HP:0008609)2.31619961
38Abnormal auditory evoked potentials (HP:0006958)2.29596306
39Bifid tongue (HP:0010297)2.28146310
40Hand muscle atrophy (HP:0009130)2.25842621
41Subacute progressive viral hepatitis (HP:0006572)2.25528438
42Short humerus (HP:0005792)2.25478255
43Nasal polyposis (HP:0100582)2.23794864
44Epileptic encephalopathy (HP:0200134)2.23760869
45Meckel diverticulum (HP:0002245)2.22581893
46Right ventricular cardiomyopathy (HP:0011663)2.20556210
47Duplicated collecting system (HP:0000081)2.19580363
48Hypoplastic ischia (HP:0003175)2.19554928
49Neoplasm of the oral cavity (HP:0100649)2.19147096
50Ependymoma (HP:0002888)2.18392670
51Abnormality of the ischium (HP:0003174)2.17030832
52Lip pit (HP:0100267)2.16980797
53Ventricular fibrillation (HP:0001663)2.15958659
54Progressive cerebellar ataxia (HP:0002073)2.14654491
55Aplasia/Hypoplasia of the sternum (HP:0006714)2.14294182
56Bundle branch block (HP:0011710)2.13813717
57Hypercortisolism (HP:0001578)2.12339130
58Fair hair (HP:0002286)2.09884573
59Amblyopia (HP:0000646)2.06481372
60Impulsivity (HP:0100710)2.06232383
61Cerebellar dysplasia (HP:0007033)2.06202178
62Entropion (HP:0000621)2.06080756
63Short hallux (HP:0010109)2.05951143
64Sensory axonal neuropathy (HP:0003390)2.05377108
65Neoplasm of the adrenal cortex (HP:0100641)2.04444276
66Abnormality of the renal collecting system (HP:0004742)2.03987503
67Urinary bladder sphincter dysfunction (HP:0002839)2.03446432
68Abnormality of DNA repair (HP:0003254)2.03214011
69Cutaneous finger syndactyly (HP:0010554)2.02723425
70Aplasia/hypoplasia of the humerus (HP:0006507)2.00862003
71Ankle clonus (HP:0011448)2.00473363
72Chorioretinal atrophy (HP:0000533)2.00277978
73Pigmentary retinal degeneration (HP:0001146)1.98978019
74Skull defect (HP:0001362)1.97856460
75EMG: neuropathic changes (HP:0003445)1.97767507
76Absent radius (HP:0003974)1.97762878
77Rib fusion (HP:0000902)1.97743397
78Wide intermamillary distance (HP:0006610)1.96484612
79Tubular atrophy (HP:0000092)1.96346368
80Sloping forehead (HP:0000340)1.95977361
81Abnormality of the duodenum (HP:0002246)1.95946272
82Spastic tetraparesis (HP:0001285)1.95421917
83Atonic seizures (HP:0010819)1.95192369
84Heterotopia (HP:0002282)1.94610252
85Abnormality of the pubic bones (HP:0003172)1.93107827
86Febrile seizures (HP:0002373)1.92579437
87Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90697749
88Action tremor (HP:0002345)1.90116731
89Abnormal lung lobation (HP:0002101)1.89938170
90Abnormality of the labia minora (HP:0012880)1.89615382
91Distal upper limb amyotrophy (HP:0007149)1.89139723
92Upper limb amyotrophy (HP:0009129)1.89139723
93Malnutrition (HP:0004395)1.88549588
94Shawl scrotum (HP:0000049)1.88078607
95Prominent nose (HP:0000448)1.85669265
96Enlarged kidneys (HP:0000105)1.85236637
97Abnormality of the carotid arteries (HP:0005344)1.84065480
98Aplasia involving forearm bones (HP:0009822)1.83806187
99Absent forearm bone (HP:0003953)1.83806187
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.82810100
101Hypoplasia of the fovea (HP:0007750)1.82810100
102Papillary thyroid carcinoma (HP:0002895)1.82548743
103Aplasia/Hypoplasia of the hallux (HP:0008362)1.82008359
104Dysmetric saccades (HP:0000641)1.81644442
105Abnormality of abdominal situs (HP:0011620)1.81629881
106Abdominal situs inversus (HP:0003363)1.81629881
107Long nose (HP:0003189)1.81411015
108Underdeveloped nasal alae (HP:0000430)1.81394753
109Meningioma (HP:0002858)1.81124757
110Short chin (HP:0000331)1.79326429
111Difficulty climbing stairs (HP:0003551)1.79034918
112Stillbirth (HP:0003826)1.78863409
113Pancreatic cysts (HP:0001737)1.78685910
114Neoplasm of the heart (HP:0100544)1.78316705
115Myelomeningocele (HP:0002475)1.77756424
116Supranuclear gaze palsy (HP:0000605)1.77581590
117Impaired vibration sensation in the lower limbs (HP:0002166)1.77502966
118Potter facies (HP:0002009)1.77490336
119Facial shape deformation (HP:0011334)1.77490336
120Clubbing of toes (HP:0100760)1.77137143
121Genetic anticipation (HP:0003743)1.76866144
122Choroideremia (HP:0001139)1.75866873
123Cutaneous syndactyly (HP:0012725)1.73259046
124Abnormality of the nasolacrimal system (HP:0000614)1.73115844
125Rhabdomyosarcoma (HP:0002859)1.73035091
126Biliary tract neoplasm (HP:0100574)1.72881872
127Hemiparesis (HP:0001269)1.70336883
128Medulloblastoma (HP:0002885)1.69610358
129Abnormality of the renal cortex (HP:0011035)1.69184734
130Abnormality of the nasal mucosa (HP:0000433)1.68949469
131Hamartoma of the eye (HP:0010568)1.68329000
132Impaired smooth pursuit (HP:0007772)1.67503094
133Clitoromegaly (HP:0000057)1.67422041
134Absent eyebrow (HP:0002223)1.67405357
135Facial cleft (HP:0002006)1.67266542
136Bronchiectasis (HP:0002110)1.66880220
137Spinal muscular atrophy (HP:0007269)1.65984831
138Asymmetry of the thorax (HP:0001555)1.65844364
139Abnormality of ocular smooth pursuit (HP:0000617)1.65730632
140Bicornuate uterus (HP:0000813)1.64015270
141Aplasia/Hypoplasia of the tibia (HP:0005772)1.63582647
142Capillary hemangiomas (HP:0005306)1.63263061
143Nephronophthisis (HP:0000090)1.63140527
144Postural instability (HP:0002172)1.63103728
145Abnormality of the labia majora (HP:0012881)1.63057057
146Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.62666364
147Breast carcinoma (HP:0003002)1.62542231
148Synostosis of carpal bones (HP:0005048)1.62531380
149Renal duplication (HP:0000075)1.61738057
150Glioma (HP:0009733)1.61674452
151Protruding tongue (HP:0010808)1.61029422
152Pendular nystagmus (HP:0012043)1.60569264
153Short thumb (HP:0009778)1.60261835
154Insomnia (HP:0100785)1.58313798
155Cerebral inclusion bodies (HP:0100314)1.57580778
156Generalized tonic-clonic seizures (HP:0002069)1.55859778
157Dysdiadochokinesis (HP:0002075)1.55221722
158Absence seizures (HP:0002121)1.54548693
159Hyperacusis (HP:0010780)1.53987121
160Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.52454802
161Turricephaly (HP:0000262)1.51503057
162Muscle fibrillation (HP:0010546)1.49721048
163Urinary urgency (HP:0000012)1.49663335
164Neoplasm of striated muscle (HP:0009728)1.48534808
165Tongue fasciculations (HP:0001308)1.48280071
166Abnormality of the aortic arch (HP:0012303)1.46831086
167Clonus (HP:0002169)1.46134723
168Intellectual disability, profound (HP:0002187)1.45736513
169Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.42896307
170Short 1st metacarpal (HP:0010034)1.42896307
171Impaired vibratory sensation (HP:0002495)1.42416476
172Hyperparathyroidism (HP:0000843)1.42356399
173Insidious onset (HP:0003587)1.41839175
174Termporal pattern (HP:0011008)1.41839175
175Elfin facies (HP:0004428)1.40455059
176Truncal obesity (HP:0001956)1.39707100
177Dialeptic seizures (HP:0011146)1.38762071
178Lower limb muscle weakness (HP:0007340)1.38689272
179Pointed chin (HP:0000307)1.38686086
180Hypoplastic labia majora (HP:0000059)1.37938462
181Urethral obstruction (HP:0000796)1.37735738
182Gaze-evoked nystagmus (HP:0000640)1.37286299
183Short phalanx of the thumb (HP:0009660)1.36942943
184Supernumerary spleens (HP:0009799)1.36529808
185Depression (HP:0000716)1.35572611
186Ulnar claw (HP:0001178)1.35276561
187Dysautonomia (HP:0002459)1.35269870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.17002710
2PRKD34.68150111
3ZAK3.95808121
4ICK3.90309698
5PDK43.68711904
6PDK33.68711904
7MAP3K93.66116610
8TESK13.08609465
9ACVR1B2.98659785
10MST42.61382016
11MET2.59266865
12LATS22.56429100
13MST1R2.55542357
14TYRO32.45275753
15STK382.35823505
16PDK22.28534389
17BUB12.27840090
18BMPR1B2.07268609
19BRSK22.05702972
20NTRK12.02996898
21PBK2.00442975
22NTRK31.97785756
23PAK61.97569842
24EIF2AK31.95558058
25TIE11.94374083
26STK241.83555285
27KSR21.78897797
28MAP3K41.73201490
29TLK11.66072620
30DDR21.58100925
31AKT31.56346297
32MAP3K61.51028905
33EPHA41.47121923
34MARK11.46636672
35TRIM281.45727882
36CDC71.40951743
37RIPK11.38735778
38EPHA21.38118917
39DAPK21.33156712
40CDK121.31134594
41TTK1.30720611
42MINK11.30520589
43NLK1.30310310
44LMTK21.27115887
45GRK11.25861772
46TAOK11.25646135
47MELK1.25252497
48PINK11.23204950
49NTRK21.22671924
50NEK11.22304899
51FGFR21.21375895
52PLK31.18908183
53DAPK11.18689114
54MUSK1.17574372
55CSNK1G11.16046993
56GRK51.15609004
57PNCK1.14834962
58PIK3CG1.12225376
59MAP3K21.09712024
60PLK41.09383272
61TRIB31.09348247
62VRK11.02319567
63NUAK11.01633524
64TSSK61.01306300
65MATK1.00788924
66WNK41.00538253
67ALK1.00074318
68ERBB40.99677178
69PTK2B0.96007987
70CAMKK10.95773657
71OXSR10.94569259
72TGFBR10.94292613
73NEK60.94207222
74DYRK1B0.93614589
75MAPK150.93565068
76TNIK0.92703725
77PDGFRA0.92514160
78WNK10.85345415
79CASK0.81323687
80NEK20.81292418
81BRD40.80758025
82MAP3K130.78770156
83TGFBR20.77790251
84BMX0.75716441
85MAP2K40.75328506
86NEK90.74885858
87STK38L0.74600652
88PDK10.73934632
89MARK20.72784697
90LATS10.72207472
91EEF2K0.72192382
92STK100.71961067
93AURKB0.71787208
94UHMK10.69638499
95CDK90.69226784
96CDK50.67076935
97CDK80.67016678
98CDC42BPA0.66958077
99FLT30.66590428
100CSNK1A1L0.65418389
101CAMK1D0.65359324
102CDK150.65190260
103PHKG10.65046162
104PHKG20.65046162
105CHEK20.64849148
106PRKCG0.64807213
107MKNK20.64234936
108PTK20.63854091
109CAMK1G0.63834066
110PDPK10.63349671
111PRKD20.62689322
112ATM0.61383178
113CDK180.61275820
114AURKA0.61196353
115FER0.60938846
116MTOR0.60271141
117ATR0.59685601
118MAP2K10.59322145
119SRPK10.57421200
120WNK30.56828113
121CDK11A0.55285325
122NME10.54669340
123MOS0.54397576
124CDK140.52947302
125PRKAA10.52895033
126RET0.52413311
127PRKG20.52062828
128KSR10.51933956
129PLK10.49531880
130PRKCE0.49196398
131STK110.47107267
132ADRBK10.46635875
133MAPK110.45515947
134MAP2K70.45107076
135BRSK10.44675518
136PKN20.44456039
137CSNK1G30.44138903
138MAP3K80.44055686
139PRPF4B0.42870761
140PAK30.42745387
141RPS6KA50.42471963
142STK390.41337122
143PRKCI0.41220637
144FGFR10.40960555
145MAP3K100.40121652
146ARAF0.39852094
147BRAF0.39517907
148STK40.39449850
149RPS6KB20.38825875
150GSK3A0.37730621
151INSRR0.37310950
152MAPK100.37237621
153CSNK1E0.36965118
154MAP3K120.36611617
155TRPM70.35723920
156EIF2AK20.34993208
157MAP2K60.34584940
158FGR0.33862663
159CHEK10.33762675
160PAK40.32893537
161GSK3B0.32687496
162CAMK2A0.32390856
163PAK10.32357685
164PRKCZ0.32250846
165RPS6KA30.31761746
166STK30.31530263
167PLK20.30088856
168MAP3K10.28725363
169MAPKAPK30.28579581
170SCYL20.28374235
171CDK20.27632184

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.83390635
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.80714579
3Non-homologous end-joining_Homo sapiens_hsa034502.76747790
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.70322028
5Homologous recombination_Homo sapiens_hsa034402.67303474
6Systemic lupus erythematosus_Homo sapiens_hsa053222.56618284
7Basal transcription factors_Homo sapiens_hsa030222.53061469
8Selenocompound metabolism_Homo sapiens_hsa004502.43635798
9Fatty acid biosynthesis_Homo sapiens_hsa000612.39004709
10p53 signaling pathway_Homo sapiens_hsa041152.32983488
11Mismatch repair_Homo sapiens_hsa034302.28466621
12Amphetamine addiction_Homo sapiens_hsa050312.11998373
13Fanconi anemia pathway_Homo sapiens_hsa034602.05382908
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.01845662
15Insulin secretion_Homo sapiens_hsa049111.95484206
16Cell cycle_Homo sapiens_hsa041101.95127199
17RNA degradation_Homo sapiens_hsa030181.92986733
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92839669
19Long-term potentiation_Homo sapiens_hsa047201.91653870
20Nucleotide excision repair_Homo sapiens_hsa034201.86455268
21Oocyte meiosis_Homo sapiens_hsa041141.83913357
22Alcoholism_Homo sapiens_hsa050341.82047519
23Nicotine addiction_Homo sapiens_hsa050331.72317041
24Salivary secretion_Homo sapiens_hsa049701.70069078
25Dorso-ventral axis formation_Homo sapiens_hsa043201.67859133
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.66069263
27DNA replication_Homo sapiens_hsa030301.65147338
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62515048
29ECM-receptor interaction_Homo sapiens_hsa045121.58846002
30Gastric acid secretion_Homo sapiens_hsa049711.56844892
31One carbon pool by folate_Homo sapiens_hsa006701.55879192
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.55742193
33TGF-beta signaling pathway_Homo sapiens_hsa043501.55492024
34Circadian entrainment_Homo sapiens_hsa047131.55007608
35Estrogen signaling pathway_Homo sapiens_hsa049151.54753294
36Olfactory transduction_Homo sapiens_hsa047401.54618084
37mTOR signaling pathway_Homo sapiens_hsa041501.51949450
38Vitamin B6 metabolism_Homo sapiens_hsa007501.50347764
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47710313
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.47407867
41Dopaminergic synapse_Homo sapiens_hsa047281.46212255
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44039815
43Glutamatergic synapse_Homo sapiens_hsa047241.41135372
44Hedgehog signaling pathway_Homo sapiens_hsa043401.41076499
45Fructose and mannose metabolism_Homo sapiens_hsa000511.40983790
46RNA polymerase_Homo sapiens_hsa030201.37646226
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37613119
48Mineral absorption_Homo sapiens_hsa049781.35790515
49Renin secretion_Homo sapiens_hsa049241.33525864
50GnRH signaling pathway_Homo sapiens_hsa049121.28945254
51Glucagon signaling pathway_Homo sapiens_hsa049221.28584336
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26562976
53Taste transduction_Homo sapiens_hsa047421.24045048
54Small cell lung cancer_Homo sapiens_hsa052221.23609070
55Hippo signaling pathway_Homo sapiens_hsa043901.18840426
56GABAergic synapse_Homo sapiens_hsa047271.18696904
57MicroRNAs in cancer_Homo sapiens_hsa052061.17616923
58Gap junction_Homo sapiens_hsa045401.16929431
59Protein digestion and absorption_Homo sapiens_hsa049741.16659557
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.15354365
61Lysine degradation_Homo sapiens_hsa003101.14853246
62Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14697294
63Oxytocin signaling pathway_Homo sapiens_hsa049211.14543603
64Cocaine addiction_Homo sapiens_hsa050301.11379731
65Vitamin digestion and absorption_Homo sapiens_hsa049771.08893505
66Collecting duct acid secretion_Homo sapiens_hsa049661.08206974
67Cholinergic synapse_Homo sapiens_hsa047251.07763403
68VEGF signaling pathway_Homo sapiens_hsa043701.07276067
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04694790
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04616757
71Long-term depression_Homo sapiens_hsa047301.04221670
72Morphine addiction_Homo sapiens_hsa050321.03547543
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01948324
74Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01816699
75Tight junction_Homo sapiens_hsa045301.00986315
76Viral carcinogenesis_Homo sapiens_hsa052030.99662584
77Melanoma_Homo sapiens_hsa052180.99392724
78ABC transporters_Homo sapiens_hsa020100.99244742
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.98901688
80Caffeine metabolism_Homo sapiens_hsa002320.98832566
81Thyroid hormone synthesis_Homo sapiens_hsa049180.98149492
82Type II diabetes mellitus_Homo sapiens_hsa049300.97528231
83mRNA surveillance pathway_Homo sapiens_hsa030150.97125285
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.96963381
85N-Glycan biosynthesis_Homo sapiens_hsa005100.96914896
86Focal adhesion_Homo sapiens_hsa045100.96710383
87ErbB signaling pathway_Homo sapiens_hsa040120.94682531
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93333524
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92982541
90Calcium signaling pathway_Homo sapiens_hsa040200.92496817
91Melanogenesis_Homo sapiens_hsa049160.90381736
92Base excision repair_Homo sapiens_hsa034100.89796468
93Glioma_Homo sapiens_hsa052140.88983705
94Choline metabolism in cancer_Homo sapiens_hsa052310.88607321
95cAMP signaling pathway_Homo sapiens_hsa040240.85914736
96Wnt signaling pathway_Homo sapiens_hsa043100.85804323
97Purine metabolism_Homo sapiens_hsa002300.85137945
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85113010
99Proteoglycans in cancer_Homo sapiens_hsa052050.83729800
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82961648
101Endometrial cancer_Homo sapiens_hsa052130.80963310
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.80524046
103Phototransduction_Homo sapiens_hsa047440.79860003
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79841857
105Glycerolipid metabolism_Homo sapiens_hsa005610.79403313
106Pyrimidine metabolism_Homo sapiens_hsa002400.77140866
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.77062553
108Circadian rhythm_Homo sapiens_hsa047100.76335528
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76247809
110Fat digestion and absorption_Homo sapiens_hsa049750.75307941
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74911550
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74617795
113Adherens junction_Homo sapiens_hsa045200.74325631
114Bile secretion_Homo sapiens_hsa049760.72876989
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72313683
116Vibrio cholerae infection_Homo sapiens_hsa051100.68841849
117Pancreatic secretion_Homo sapiens_hsa049720.68810106
118Endocytosis_Homo sapiens_hsa041440.68746241
119Prostate cancer_Homo sapiens_hsa052150.67910465
120Galactose metabolism_Homo sapiens_hsa000520.67382913
121Inositol phosphate metabolism_Homo sapiens_hsa005620.65430586
122MAPK signaling pathway_Homo sapiens_hsa040100.65391384
123Basal cell carcinoma_Homo sapiens_hsa052170.64047323
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63936265
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63640950
126RNA transport_Homo sapiens_hsa030130.63182426
127Axon guidance_Homo sapiens_hsa043600.63035907
128AMPK signaling pathway_Homo sapiens_hsa041520.62354165
129Serotonergic synapse_Homo sapiens_hsa047260.62303092
130Folate biosynthesis_Homo sapiens_hsa007900.61908701
131Linoleic acid metabolism_Homo sapiens_hsa005910.61366127
132Insulin signaling pathway_Homo sapiens_hsa049100.61032629
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60700520
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57708266
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57253315
136Bladder cancer_Homo sapiens_hsa052190.56623739
137Rap1 signaling pathway_Homo sapiens_hsa040150.54776676
138Cardiac muscle contraction_Homo sapiens_hsa042600.54601703
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54191391
140Thyroid cancer_Homo sapiens_hsa052160.52630048
141Pathways in cancer_Homo sapiens_hsa052000.51424289
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50800412
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.49531187
144Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49434720
145FoxO signaling pathway_Homo sapiens_hsa040680.46956832
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.46737651
147Ovarian steroidogenesis_Homo sapiens_hsa049130.46633802
148Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46411437
149Ras signaling pathway_Homo sapiens_hsa040140.43307096
150Insulin resistance_Homo sapiens_hsa049310.40338896
151Sphingolipid metabolism_Homo sapiens_hsa006000.40302278
152Nitrogen metabolism_Homo sapiens_hsa009100.40095358
153Ether lipid metabolism_Homo sapiens_hsa005650.35919240
154Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34749887
155Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33707635
156Glutathione metabolism_Homo sapiens_hsa004800.29257854
157Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28765501

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »