OSBPL11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)6.11832877
2positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.74712211
3positive regulation of gamma-delta T cell activation (GO:0046645)5.35418874
4low-density lipoprotein particle clearance (GO:0034383)5.02561950
5neutrophil activation involved in immune response (GO:0002283)4.97229054
6detection of other organism (GO:0098543)4.90066392
7cellular extravasation (GO:0045123)4.88250099
8detection of external biotic stimulus (GO:0098581)4.73520525
9negative regulation of cell killing (GO:0031342)4.70580668
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.70580668
11response to peptidoglycan (GO:0032494)4.42157879
12regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.37066511
13macrophage activation (GO:0042116)4.26629008
14regulation of cholesterol storage (GO:0010885)4.22928753
15production of molecular mediator involved in inflammatory response (GO:0002532)4.16506303
16negative regulation of interleukin-12 production (GO:0032695)4.12914291
17detection of biotic stimulus (GO:0009595)4.10711510
18regulation of gamma-delta T cell activation (GO:0046643)4.05257645
19regulation of B cell receptor signaling pathway (GO:0050855)4.04273408
20detection of bacterium (GO:0016045)4.02390727
21positive regulation of cellular amide metabolic process (GO:0034250)4.01233589
22* regulation of sequestering of triglyceride (GO:0010889)3.95677953
23neutrophil mediated immunity (GO:0002446)3.78423965
24negative regulation of granulocyte differentiation (GO:0030853)3.77570240
25respiratory burst (GO:0045730)3.69504708
26positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.66753932
27response to host immune response (GO:0052572)3.64673935
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.64673935
29positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.62260928
30white fat cell differentiation (GO:0050872)3.55975301
31regulation of mast cell degranulation (GO:0043304)3.55624654
32monoubiquitinated protein deubiquitination (GO:0035520)3.55152255
33fatty acid transmembrane transport (GO:1902001)3.51705117
34neutrophil activation (GO:0042119)3.50770562
35myeloid cell activation involved in immune response (GO:0002275)3.46414088
36myeloid leukocyte mediated immunity (GO:0002444)3.44419354
37negative regulation of lymphocyte mediated immunity (GO:0002707)3.43305781
38apoptotic cell clearance (GO:0043277)3.43059954
39positive regulation of fatty acid beta-oxidation (GO:0032000)3.39693159
40cytoplasmic mRNA processing body assembly (GO:0033962)3.38628355
41leukocyte migration involved in inflammatory response (GO:0002523)3.38490437
42regulation of mast cell activation (GO:0033003)3.38374379
43regulation of mast cell activation involved in immune response (GO:0033006)3.36945064
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.35992876
45positive regulation of macrophage cytokine production (GO:0060907)3.35891896
46regulation of gamma-delta T cell differentiation (GO:0045586)3.35287223
47positive regulation of mast cell activation (GO:0033005)3.29912936
48I-kappaB phosphorylation (GO:0007252)3.28340995
49fibroblast migration (GO:0010761)3.27045561
50regulation of myeloid leukocyte mediated immunity (GO:0002886)3.25100139
51growth hormone receptor signaling pathway (GO:0060396)3.24836607
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23864386
53response to host (GO:0075136)3.23864386
54response to host defenses (GO:0052200)3.23864386
55granulocyte activation (GO:0036230)3.17667686
56negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.17323516
57negative regulation of T cell mediated immunity (GO:0002710)3.15462815
58regulation of leukocyte degranulation (GO:0043300)3.15242043
59carnitine shuttle (GO:0006853)3.14389156
60sarcoplasmic reticulum calcium ion transport (GO:0070296)3.11150938
61regulation of fatty acid beta-oxidation (GO:0031998)3.08612148
62nuclear pore complex assembly (GO:0051292)3.08562575
63immunoglobulin mediated immune response (GO:0016064)3.05760466
64negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.05656001
65phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.05470642
66leukocyte aggregation (GO:0070486)3.03744628
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.01604820
68modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.01604820
69positive regulation by organism of defense response of other organism involved in symbiotic interact3.01604820
70modulation by symbiont of host immune response (GO:0052553)3.01604820
71positive regulation by symbiont of host defense response (GO:0052509)3.01604820
72modulation by symbiont of host defense response (GO:0052031)3.01604820
73actin-myosin filament sliding (GO:0033275)3.01589451
74muscle filament sliding (GO:0030049)3.01589451
75biotin metabolic process (GO:0006768)3.00504679
76regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.99282172
77regulation of mitotic spindle organization (GO:0060236)2.99149296
78regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.98341571
79brown fat cell differentiation (GO:0050873)2.97466372
80positive regulation of toll-like receptor signaling pathway (GO:0034123)2.95942775
81regulation of macrophage cytokine production (GO:0010935)2.95645264
82negative regulation of toll-like receptor signaling pathway (GO:0034122)2.95561851
83dendritic cell migration (GO:0036336)2.95189961
84regulation of interferon-beta biosynthetic process (GO:0045357)2.94116749
85iron ion import (GO:0097286)2.92748235
86positive regulation of fatty acid oxidation (GO:0046321)2.92645189
87B cell receptor signaling pathway (GO:0050853)2.92462426
88regulation of macrophage chemotaxis (GO:0010758)2.91727368
89mitotic chromosome condensation (GO:0007076)2.86674956
90negative regulation of lipid storage (GO:0010888)2.86223991
91skeletal muscle contraction (GO:0003009)2.84978161
92cellular response to ethanol (GO:0071361)2.84589208
93regulation of tolerance induction (GO:0002643)2.84154638
94negative regulation of macrophage differentiation (GO:0045650)2.83432212
95regulation of spindle organization (GO:0090224)2.82952227
96negative regulation of interleukin-17 production (GO:0032700)2.82489424
97intracellular lipid transport (GO:0032365)2.82159666
98antigen processing and presentation of endogenous antigen (GO:0019883)2.81854825
99microglial cell activation (GO:0001774)2.81225297
100valine metabolic process (GO:0006573)2.80854614
101antigen processing and presentation via MHC class Ib (GO:0002475)2.80356209
102regulation of tight junction assembly (GO:2000810)2.80280495
103negative regulation of leukocyte mediated immunity (GO:0002704)2.79829654
104positive regulation of mast cell degranulation (GO:0043306)2.79534274
105positive regulation of mast cell activation involved in immune response (GO:0033008)2.79534274
106regulation of T cell tolerance induction (GO:0002664)2.78572989
107neutrophil chemotaxis (GO:0030593)2.78546018
108positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.78269697
109cellular response to growth hormone stimulus (GO:0071378)2.77208406
110nuclear pore organization (GO:0006999)2.74424094
111regulation of cellular amide metabolic process (GO:0034248)2.74350679
112cellular polysaccharide catabolic process (GO:0044247)2.73349322
113triglyceride catabolic process (GO:0019433)2.72073165
114regulation of beta-amyloid formation (GO:1902003)2.71391116
115oligosaccharide catabolic process (GO:0009313)2.71277083
116neutrophil migration (GO:1990266)2.70488431
117regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.68219632
118actin-mediated cell contraction (GO:0070252)2.67382657
119regulation of interleukin-8 biosynthetic process (GO:0045414)2.67376055
120lipid storage (GO:0019915)2.67222385
121regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.65331840
122glucan catabolic process (GO:0009251)2.64208325
123negative regulation of B cell mediated immunity (GO:0002713)2.63350090
124negative regulation of immunoglobulin mediated immune response (GO:0002890)2.63350090
125B cell mediated immunity (GO:0019724)2.62944856
126pentose-phosphate shunt (GO:0006098)2.62112041
127regulation of sister chromatid cohesion (GO:0007063)2.61923154
128response to interleukin-15 (GO:0070672)2.60417220
129polysaccharide catabolic process (GO:0000272)2.60337377
130negative regulation of exocytosis (GO:0045920)2.59459936
131negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.58908519
132peptidyl-threonine phosphorylation (GO:0018107)2.58748197
133positive regulation of B cell differentiation (GO:0045579)2.58485454
134regulation of RNA export from nucleus (GO:0046831)2.58358590
135antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.58149123
136positive regulation of leukocyte degranulation (GO:0043302)2.57731996
137regulation of interferon-alpha production (GO:0032647)2.57248740
138NADPH regeneration (GO:0006740)2.56278638
139macrophage activation involved in immune response (GO:0002281)2.55735482
140mitotic metaphase plate congression (GO:0007080)2.55279573
141vascular endothelial growth factor signaling pathway (GO:0038084)2.54957101
142plasma lipoprotein particle clearance (GO:0034381)2.53079083
143positive regulation of cholesterol efflux (GO:0010875)2.51443356
144protein localization to kinetochore (GO:0034501)2.50671534
145positive regulation of histone deacetylation (GO:0031065)2.50554602
146protein localization to chromosome, centromeric region (GO:0071459)2.50325799
147response to laminar fluid shear stress (GO:0034616)2.49753071
148pore complex assembly (GO:0046931)2.49302534
149histone H3-K9 demethylation (GO:0033169)2.48274878
150positive regulation of mitotic sister chromatid separation (GO:1901970)2.47212990
151positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.47212990
152positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.47212990
153* positive regulation of lipid storage (GO:0010884)2.46266647
154regulation of fatty acid oxidation (GO:0046320)2.45911780
155NLS-bearing protein import into nucleus (GO:0006607)2.44556768
156positive regulation of cholesterol transport (GO:0032376)2.41496128
157positive regulation of sterol transport (GO:0032373)2.41496128
158histone H2A monoubiquitination (GO:0035518)2.40012121
159regulation of nucleobase-containing compound transport (GO:0032239)2.39833111
160alpha-linolenic acid metabolic process (GO:0036109)2.38578691
161positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.38249965
162regulation of hippo signaling (GO:0035330)2.38186711
163neutral lipid catabolic process (GO:0046461)2.37164181
164acylglycerol catabolic process (GO:0046464)2.37164181
165mitotic sister chromatid cohesion (GO:0007064)2.35872912
166carnitine transmembrane transport (GO:1902603)2.35418721
167positive regulation of chromosome segregation (GO:0051984)2.34686064
168positive regulation of lipid catabolic process (GO:0050996)2.33129520
169positive regulation of SMAD protein import into nucleus (GO:0060391)2.30116470
170complement activation, alternative pathway (GO:0006957)2.30079698
171regulation of SMAD protein import into nucleus (GO:0060390)2.29706352
172basement membrane organization (GO:0071711)2.28605203
173ovulation from ovarian follicle (GO:0001542)2.27970087
174positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.27907182
175phospholipid homeostasis (GO:0055091)2.27489077
176response to UV-C (GO:0010225)2.27457139
177regulation of mononuclear cell migration (GO:0071675)2.27251910
178female genitalia development (GO:0030540)2.25263205
179germ cell migration (GO:0008354)2.24365059
180fatty acid beta-oxidation (GO:0006635)2.24138480
181regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.24089012
182histone H3-K36 demethylation (GO:0070544)2.23419426
183mitotic nuclear envelope disassembly (GO:0007077)2.22072202
184positive regulation of interferon-alpha production (GO:0032727)2.21799441
185lipoprotein transport (GO:0042953)2.21479430
186amino-acid betaine transport (GO:0015838)2.20671093
187carnitine transport (GO:0015879)2.20671093
188vagina development (GO:0060068)2.18932927

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.32410803
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.01264008
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.41776779
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.09048381
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.53239847
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.31020181
7* CLOCK_20551151_ChIP-Seq_293T_Human3.06290434
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.86857959
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.84686975
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.59034541
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.52994960
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.29060986
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.10535723
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.05555648
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00376694
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.98845586
17AR_21909140_ChIP-Seq_LNCAP_Human1.98836099
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.98663620
19* LXR_22158963_ChIP-Seq_LIVER_Mouse1.98120551
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93666931
21* SPI1_23547873_ChIP-Seq_NB4_Human1.93469413
22* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90414852
23PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.89325859
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82672323
25PU_27001747_Chip-Seq_BMDM_Mouse1.76379345
26CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.76176556
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.75800657
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72927677
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71780869
30MYC_22102868_ChIP-Seq_BL_Human1.70027038
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.65772380
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64857501
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.64793802
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63332514
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62570833
36TCF7_22412390_ChIP-Seq_EML_Mouse1.59567417
37* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57335631
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56876033
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.54550087
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.53944085
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52634560
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52191386
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.49243946
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.47281383
45MYB_26560356_Chip-Seq_TH2_Human1.47033880
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.45478005
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.42369583
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41942100
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40485364
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39044309
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38764461
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38447748
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38304394
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38299693
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.37753182
56KDM2B_26808549_Chip-Seq_DND41_Human1.36588152
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.36275416
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.34296306
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33699903
60GATA1_22025678_ChIP-Seq_K562_Human1.31988367
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31324231
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29754156
63ATF3_27146783_Chip-Seq_COLON_Human1.29069711
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27997626
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27348972
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26841217
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.26627632
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26301956
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26148721
70GF1_26923725_Chip-Seq_HPCs_Mouse1.26103695
71VDR_21846776_ChIP-Seq_THP-1_Human1.24740157
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24026885
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23843399
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.23699536
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23252722
76MAF_26560356_Chip-Seq_TH1_Human1.19492070
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17954501
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16292310
79FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16159206
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16156977
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15277293
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15153401
83FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14710775
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14519127
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13921558
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13703997
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12812330
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12673764
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12369574
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11767167
91KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.11725754
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11258190
93SCL_19346495_ChIP-Seq_HPC-7_Human1.10876475
94ER_23166858_ChIP-Seq_MCF-7_Human1.10407191
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10311210
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10311210
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10311210
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09824208
99FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09494720
100NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08196503
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08196503
102STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07112998
103TFEB_21752829_ChIP-Seq_HELA_Human1.06459559
104* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.06374116
105UTX_26944678_Chip-Seq_JUKART_Human1.05373393
106BRD4_25478319_ChIP-Seq_HGPS_Human1.05057416
107* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04914515
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04757921
109TP63_19390658_ChIP-ChIP_HaCaT_Human1.04659201
110GATA3_27048872_Chip-Seq_THYMUS_Human1.04454914
111TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04389767
112PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03925373
113PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03678088
114KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02858129
115ZNF263_19887448_ChIP-Seq_K562_Human1.02419825
116SALL4_22934838_ChIP-ChIP_CD34+_Human1.02136822
117RUNX_20019798_ChIP-Seq_JUKART_Human1.01627983
118TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01208216
119UBF1/2_26484160_Chip-Seq_HMECs_Human0.99142617
120VDR_24787735_ChIP-Seq_THP-1_Human0.98968438
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98859914
122OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98761546
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98566736
124VDR_24763502_ChIP-Seq_THP-1_Human0.98022020
125FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98010944
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97990845
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97660518
128MYB_26560356_Chip-Seq_TH1_Human0.97562553
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96175235
130GATA3_26560356_Chip-Seq_TH2_Human0.95775342
131NOTCH1_21737748_ChIP-Seq_TLL_Human0.95520568
132CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95441650
133STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95043718
134CJUN_26792858_Chip-Seq_BT549_Human0.94607626
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93920889
136* SPI1_23127762_ChIP-Seq_K562_Human0.93570367
137TAF15_26573619_Chip-Seq_HEK293_Human0.93349965
138HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92665830
139NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92629688
140DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91890625
141NCOR1_26117541_ChIP-Seq_K562_Human0.91728134
142TBX20_22080862_ChIP-Seq_HEART_Mouse0.91423724
143TBX20_22328084_ChIP-Seq_HEART_Mouse0.91423724
144KDM2B_26808549_Chip-Seq_JURKAT_Human0.91177059
145NFE2_27457419_Chip-Seq_LIVER_Mouse0.90969238
146ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90521636
147NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90416196
148RUNX1_22412390_ChIP-Seq_EML_Mouse0.90044408
149SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89780410
150ESR1_20079471_ChIP-ChIP_T-47D_Human0.89583205
151CRX_20693478_ChIP-Seq_RETINA_Mouse0.89326048
152GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89174664
153NANOG_18555785_Chip-Seq_ESCs_Mouse0.87424538
154UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85632697
155CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85124043
156* TP63_23658742_ChIP-Seq_EP156T_Human0.84879735
157P300_19829295_ChIP-Seq_ESCs_Human0.84790447
158CDX2_22108803_ChIP-Seq_LS180_Human0.84187366
159E2F1_18555785_Chip-Seq_ESCs_Mouse0.83692276
160CMYC_18555785_Chip-Seq_ESCs_Mouse0.80577180
161SUZ12_18555785_Chip-Seq_ESCs_Mouse0.79740518
162FLI1_21867929_ChIP-Seq_TH2_Mouse0.78869981
163GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77881883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.52292904
2MP0003646_muscle_fatigue4.50950490
3MP0003724_increased_susceptibility_to3.89449900
4MP0004185_abnormal_adipocyte_glucose3.26790502
5MP0008438_abnormal_cutaneous_collagen3.25005629
6MP0003705_abnormal_hypodermis_morpholog3.15401713
7MP0005666_abnormal_adipose_tissue3.05588293
8MP0008057_abnormal_DNA_replication2.80404860
9MP0003191_abnormal_cellular_cholesterol2.42348037
10MP0008260_abnormal_autophagy2.40310437
11MP0004130_abnormal_muscle_cell2.35776671
12MP0000749_muscle_degeneration2.30533085
13MP0000569_abnormal_digit_pigmentation2.17045800
14MP0009840_abnormal_foam_cell2.16940267
15MP0002332_abnormal_exercise_endurance2.11065648
16MP0004233_abnormal_muscle_weight2.09618192
17MP0003011_delayed_dark_adaptation2.09198025
18MP0005375_adipose_tissue_phenotype2.04761900
19MP0003656_abnormal_erythrocyte_physiolo1.98551291
20MP0005076_abnormal_cell_differentiation1.94201536
21MP0005058_abnormal_lysosome_morphology1.87628589
22MP0004036_abnormal_muscle_relaxation1.86078467
23MP0009785_altered_susceptibility_to1.74549193
24MP0001800_abnormal_humoral_immune1.72854212
25MP0004883_abnormal_blood_vessel1.71727203
26MP0003566_abnormal_cell_adhesion1.62462526
27MP0003303_peritoneal_inflammation1.62092432
28MP0009115_abnormal_fat_cell1.61769395
29MP0005000_abnormal_immune_tolerance1.59851184
30MP0002971_abnormal_brown_adipose1.58815384
31MP0001790_abnormal_immune_system1.58407331
32MP0005387_immune_system_phenotype1.58407331
33MP0000685_abnormal_immune_system1.57817570
34MP0010307_abnormal_tumor_latency1.56708094
35MP0002723_abnormal_immune_serum1.55368528
36MP0005025_abnormal_response_to1.52668820
37MP0010352_gastrointestinal_tract_polyps1.49710948
38MP0010329_abnormal_lipoprotein_level1.49311089
39MP0002420_abnormal_adaptive_immunity1.47871701
40MP0005671_abnormal_response_to1.45996824
41MP0001819_abnormal_immune_cell1.45656060
42MP0005310_abnormal_salivary_gland1.40880395
43MP0005275_abnormal_skin_tensile1.39990634
44MP0005360_urolithiasis1.38279624
45MP0005451_abnormal_body_composition1.33496187
46MP0003828_pulmonary_edema1.32219724
47MP0000747_muscle_weakness1.31575598
48MP0010234_abnormal_vibrissa_follicle1.31336938
49MP0002405_respiratory_system_inflammati1.31118538
50MP0000609_abnormal_liver_physiology1.30818721
51MP0002269_muscular_atrophy1.30225026
52MP0005083_abnormal_biliary_tract1.29341872
53MP0001915_intracranial_hemorrhage1.27340183
54MP0004484_altered_response_of1.27163468
55MP0006082_CNS_inflammation1.25797817
56MP0004145_abnormal_muscle_electrophysio1.24961251
57MP0005164_abnormal_response_to1.20417429
58MP0001661_extended_life_span1.19890009
59MP0003111_abnormal_nucleus_morphology1.19847281
60MP0002009_preneoplasia1.19468994
61MP0009278_abnormal_bone_marrow1.19415136
62MP0002148_abnormal_hypersensitivity_rea1.19181123
63MP0005620_abnormal_muscle_contractility1.19037855
64MP0008007_abnormal_cellular_replicative1.18825825
65MP0003091_abnormal_cell_migration1.18773908
66MP0000733_abnormal_muscle_development1.18517417
67MP0005464_abnormal_platelet_physiology1.18334399
68MP0003279_aneurysm1.18331118
69MP0003077_abnormal_cell_cycle1.15987283
70MP0002396_abnormal_hematopoietic_system1.15595107
71MP0000767_abnormal_smooth_muscle1.15420459
72MP0002106_abnormal_muscle_physiology1.15200682
73MP0002166_altered_tumor_susceptibility1.15136769
74MP0000003_abnormal_adipose_tissue1.13191649
75MP0002088_abnormal_embryonic_growth/wei1.12843136
76MP0003436_decreased_susceptibility_to1.12609398
77MP0005330_cardiomyopathy1.11904573
78MP0001849_ear_inflammation1.11455950
79MP0003984_embryonic_growth_retardation1.11281333
80MP0005023_abnormal_wound_healing1.10740274
81MP0003448_altered_tumor_morphology1.10714710
82MP0003183_abnormal_peptide_metabolism1.10271152
83MP0000716_abnormal_immune_system1.09991169
84MP0003950_abnormal_plasma_membrane1.09845292
85MP0001672_abnormal_embryogenesis/_devel1.09721470
86MP0005380_embryogenesis_phenotype1.09721470
87MP0002972_abnormal_cardiac_muscle1.08455715
88MP0003300_gastrointestinal_ulcer1.07776900
89MP0002277_abnormal_respiratory_mucosa1.07338100
90MP0002398_abnormal_bone_marrow1.06942784
91MP0005365_abnormal_bile_salt1.05685351
92MP0002127_abnormal_cardiovascular_syste1.05042697
93MP0003045_fibrosis1.04582920
94MP0005334_abnormal_fat_pad1.04483556
95MP0002970_abnormal_white_adipose1.04367915
96MP0000751_myopathy1.03889006
97MP0001730_embryonic_growth_arrest1.03434361
98MP0005376_homeostasis/metabolism_phenot1.02836473
99MP0000689_abnormal_spleen_morphology1.02543400
100MP0008961_abnormal_basal_metabolism1.01250812
101MP0008877_abnormal_DNA_methylation1.00021392
102MP0009053_abnormal_anal_canal0.98899578
103MP0002006_tumorigenesis0.98361317
104MP0001845_abnormal_inflammatory_respons0.97492260
105MP0002697_abnormal_eye_size0.96939742
106MP0004272_abnormal_basement_membrane0.96806105
107MP0010368_abnormal_lymphatic_system0.96559497
108MP0002133_abnormal_respiratory_system0.96041522
109MP0005388_respiratory_system_phenotype0.96041522
110MP0003690_abnormal_glial_cell0.95401364
111MP0006138_congestive_heart_failure0.95201757
112MP0002086_abnormal_extraembryonic_tissu0.92606590
113MP0001727_abnormal_embryo_implantation0.92182011
114MP0002638_abnormal_pupillary_reflex0.91927356
115MP0002722_abnormal_immune_system0.91745811
116MP0003221_abnormal_cardiomyocyte_apopto0.91589011
117MP0000759_abnormal_skeletal_muscle0.90785740
118MP0003075_altered_response_to0.90333300
119MP0003693_abnormal_embryo_hatching0.89888371
120MP0004381_abnormal_hair_follicle0.89541820
121MP0005397_hematopoietic_system_phenotyp0.89527691
122MP0001545_abnormal_hematopoietic_system0.89527691
123MP0000858_altered_metastatic_potential0.88411842
124MP0000343_altered_response_to0.88274518
125MP0005085_abnormal_gallbladder_physiolo0.86851617
126MP0001835_abnormal_antigen_presentation0.86540434
127MP0001533_abnormal_skeleton_physiology0.86390779
128MP0006054_spinal_hemorrhage0.83997165
129MP0005174_abnormal_tail_pigmentation0.82184827
130MP0001853_heart_inflammation0.81946395
131MP0008469_abnormal_protein_level0.81569992
132MP0001958_emphysema0.81444025
133MP0000465_gastrointestinal_hemorrhage0.80721119
134MP0000350_abnormal_cell_proliferation0.80718411
135MP0002168_other_aberrant_phenotype0.80690295
136MP0005166_decreased_susceptibility_to0.80635239
137MP0005266_abnormal_metabolism0.80407456
138MP0010630_abnormal_cardiac_muscle0.80205970
139MP0000604_amyloidosis0.79863529
140MP0002419_abnormal_innate_immunity0.79774270
141MP0005385_cardiovascular_system_phenoty0.79758139
142MP0001544_abnormal_cardiovascular_syste0.79758139
143MP0000598_abnormal_liver_morphology0.79675543
144MP0001614_abnormal_blood_vessel0.79400184
145MP0002139_abnormal_hepatobiliary_system0.78473434
146MP0001851_eye_inflammation0.78352088
147MP0003252_abnormal_bile_duct0.78186055
148MP0002118_abnormal_lipid_homeostasis0.77838971
149MP0000750_abnormal_muscle_regeneration0.77784574
150MP0004957_abnormal_blastocyst_morpholog0.77313517
151MP0003172_abnormal_lysosome_physiology0.75783180
152MP0002429_abnormal_blood_cell0.74351678
153MP0005257_abnormal_intraocular_pressure0.70592671
154MP0001697_abnormal_embryo_size0.70561097
155MP0003123_paternal_imprinting0.70367257
156MP0004087_abnormal_muscle_fiber0.70338476
157MP0009672_abnormal_birth_weight0.70022480
158MP0002452_abnormal_antigen_presenting0.69932656
159MP0002128_abnormal_blood_circulation0.69908570
160MP0003115_abnormal_respiratory_system0.69460678
161MP0002925_abnormal_cardiovascular_devel0.68801919
162MP0010094_abnormal_chromosome_stability0.68739359
163MP0002060_abnormal_skin_morphology0.68222729
164MP0002998_abnormal_bone_remodeling0.67452761
165MP0005193_abnormal_anterior_eye0.66195136
166MP0004197_abnormal_fetal_growth/weight/0.65367234
167MP0005319_abnormal_enzyme/_coenzyme0.64898495

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)6.21848609
2Muscle fiber inclusion bodies (HP:0100299)6.17372886
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.90209314
4Exercise-induced muscle cramps (HP:0003710)4.44999773
5Stomatitis (HP:0010280)4.20003089
6Cerebral aneurysm (HP:0004944)4.13294711
7Abnormality of macrophages (HP:0004311)4.06249256
8Systemic lupus erythematosus (HP:0002725)4.04013389
9Exercise-induced myalgia (HP:0003738)3.89556549
10Retrobulbar optic neuritis (HP:0100654)3.76484178
11Optic neuritis (HP:0100653)3.76484178
12Myocardial infarction (HP:0001658)3.73900082
13Complement deficiency (HP:0004431)3.70594801
14Orchitis (HP:0100796)3.58724580
15Type 1 muscle fiber predominance (HP:0003803)3.40339562
16Subaortic stenosis (HP:0001682)3.39858940
17Abnormality of the left ventricular outflow tract (HP:0011103)3.39858940
18Spontaneous hematomas (HP:0007420)3.33503253
19Hyporeflexia of lower limbs (HP:0002600)3.30502175
20Myositis (HP:0100614)3.25461171
21EMG: myopathic abnormalities (HP:0003458)3.22177508
22Aortic aneurysm (HP:0004942)3.20466077
23Glomerulonephritis (HP:0000099)3.20369745
24Recurrent skin infections (HP:0001581)3.16565098
25T lymphocytopenia (HP:0005403)3.10212719
26Abnormality of T cell number (HP:0011839)3.09290851
27Frequent falls (HP:0002359)3.06112193
28Ankle contracture (HP:0006466)3.05740491
29Abnormality of complement system (HP:0005339)2.98884902
30Protrusio acetabuli (HP:0003179)2.90131560
31Aortic dissection (HP:0002647)2.88527042
32Mitral valve prolapse (HP:0001634)2.87420189
33Keratoconjunctivitis sicca (HP:0001097)2.86644690
34Premature rupture of membranes (HP:0001788)2.83498260
35Arterial tortuosity (HP:0005116)2.77588316
36Distal arthrogryposis (HP:0005684)2.71683016
37Hyperglycinuria (HP:0003108)2.70713281
38Recurrent fungal infections (HP:0002841)2.70480497
39Chest pain (HP:0100749)2.67477719
40Mediastinal lymphadenopathy (HP:0100721)2.67191146
41Gastrointestinal infarctions (HP:0005244)2.62335245
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.60519762
43Osteolytic defects of the hand bones (HP:0009699)2.60519762
44Vascular tortuosity (HP:0004948)2.59690398
45Papillary thyroid carcinoma (HP:0002895)2.58337478
46Global brain atrophy (HP:0002283)2.56797756
47Hypoalphalipoproteinemia (HP:0003233)2.55928036
48Cortical dysplasia (HP:0002539)2.54209043
49Hematochezia (HP:0002573)2.53202713
50Male infertility (HP:0003251)2.52187921
51Meningitis (HP:0001287)2.51193026
52Amyloidosis (HP:0011034)2.50670161
53Keratoconjunctivitis (HP:0001096)2.49120413
54Muscle hypertrophy of the lower extremities (HP:0008968)2.47782295
55Arterial thrombosis (HP:0004420)2.46867608
56Nephritis (HP:0000123)2.46583620
57Recurrent cutaneous fungal infections (HP:0011370)2.45995695
58Chronic mucocutaneous candidiasis (HP:0002728)2.45995695
59Increased connective tissue (HP:0009025)2.45288207
60Gingival bleeding (HP:0000225)2.44642507
61Rhabdomyolysis (HP:0003201)2.39722074
62Upper motor neuron abnormality (HP:0002127)2.37474537
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.37328509
64Urticaria (HP:0001025)2.36329621
65Aneurysm (HP:0002617)2.34288396
66Gingivitis (HP:0000230)2.34235242
67Nausea (HP:0002018)2.32164030
68Neck muscle weakness (HP:0000467)2.31896300
69Disinhibition (HP:0000734)2.30799712
70Osteomyelitis (HP:0002754)2.30346476
71Agnosia (HP:0010524)2.29568119
72Autoimmune thrombocytopenia (HP:0001973)2.28240682
73Areflexia of lower limbs (HP:0002522)2.27899355
74Abnormality of skeletal muscle fiber size (HP:0012084)2.27292951
75Shallow orbits (HP:0000586)2.26145762
76Recurrent gram-negative bacterial infections (HP:0005420)2.24942824
77Hand muscle atrophy (HP:0009130)2.23410908
78Subacute progressive viral hepatitis (HP:0006572)2.20794738
79Fatigue (HP:0012378)2.19296000
80Striae distensae (HP:0001065)2.18996713
81Dilatation of the ascending aorta (HP:0005111)2.18531272
82Centrally nucleated skeletal muscle fibers (HP:0003687)2.16159361
83Hypertriglyceridemia (HP:0002155)2.15239019
84Abnormality of the fingertips (HP:0001211)2.12974214
85Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12659173
86Calf muscle hypertrophy (HP:0008981)2.12374501
87Abnormality of the endocardium (HP:0004306)2.11065890
88Bicuspid aortic valve (HP:0001647)2.10867295
89Lymphangioma (HP:0100764)2.08976416
90Vasculitis (HP:0002633)2.08698444
91Abnormality of liposaccharide metabolism (HP:0010968)2.08604038
92Abnormality of glycosphingolipid metabolism (HP:0004343)2.08604038
93Abnormality of glycolipid metabolism (HP:0010969)2.08604038
94Reduced subcutaneous adipose tissue (HP:0003758)2.07648556
95Hypochromic microcytic anemia (HP:0004840)2.07511024
96Camptodactyly of toe (HP:0001836)2.06860547
97Abnormality of serine family amino acid metabolism (HP:0010894)2.06802010
98Abnormality of glycine metabolism (HP:0010895)2.06802010
99Amaurosis fugax (HP:0100576)2.05822123
100Multiple enchondromatosis (HP:0005701)2.04512540
101Deep venous thrombosis (HP:0002625)2.04083995
102Disproportionate tall stature (HP:0001519)2.03966746
103Encephalitis (HP:0002383)2.01897998
104Mutism (HP:0002300)2.00984440
105Acanthosis nigricans (HP:0000956)2.00663468
106Hemoptysis (HP:0002105)1.99841727
107Xanthomatosis (HP:0000991)1.99414500
108Oligomenorrhea (HP:0000876)1.98674029
109Increased cerebral lipofuscin (HP:0011813)1.98642771
110Recurrent bacterial skin infections (HP:0005406)1.98606650
111Leukocytosis (HP:0001974)1.98566034
112Soft skin (HP:0000977)1.98441040
113Eczematoid dermatitis (HP:0000976)1.97717917
114Myopathic facies (HP:0002058)1.97490016
115EMG: neuropathic changes (HP:0003445)1.96896038
116Enlarged penis (HP:0000040)1.96593137
117Inappropriate behavior (HP:0000719)1.96017247
118Viral hepatitis (HP:0006562)1.95710094
119Volvulus (HP:0002580)1.95295893
120Zonular cataract (HP:0010920)1.92289644
121Asymmetric septal hypertrophy (HP:0001670)1.91170089
122Rimmed vacuoles (HP:0003805)1.90937109
123Resting tremor (HP:0002322)1.90765144
124Recurrent abscess formation (HP:0002722)1.90446125
125Recurrent viral infections (HP:0004429)1.90404557
126Abnormality of the vasculature of the conjunctiva (HP:0008054)1.90120115
127Obstructive lung disease (HP:0006536)1.89050430
128Chronic obstructive pulmonary disease (HP:0006510)1.89050430
129Distal lower limb muscle weakness (HP:0009053)1.87076792
130Amyotrophic lateral sclerosis (HP:0007354)1.87024865
131Stomach cancer (HP:0012126)1.86288633
132Abnormality of proline metabolism (HP:0010907)1.85236286
133Hydroxyprolinuria (HP:0003080)1.85236286
134Polyneuropathy (HP:0001271)1.85120915
135Peritonitis (HP:0002586)1.84782167
136Distal upper limb amyotrophy (HP:0007149)1.84294585
137Upper limb amyotrophy (HP:0009129)1.84294585
138Urethral obstruction (HP:0000796)1.84071044
139Spondylolisthesis (HP:0003302)1.83708679
140Myoglobinuria (HP:0002913)1.83600910
141Rectal prolapse (HP:0002035)1.81512274
142Genu recurvatum (HP:0002816)1.78709995
143Abnormality of the 4th metacarpal (HP:0010012)1.78119778
144Difficulty running (HP:0009046)1.77287797
145Pulmonary infiltrates (HP:0002113)1.75758239
146Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72552768
147Short 4th metacarpal (HP:0010044)1.72552768
148Eosinophilia (HP:0001880)1.72273606
149Blue sclerae (HP:0000592)1.70982807
150Anorexia (HP:0002039)1.70091240
151Pulmonary embolism (HP:0002204)1.68919721
152Cervical subluxation (HP:0003308)1.68683415
153Hyperglycinemia (HP:0002154)1.67839602
154Azoospermia (HP:0000027)1.67518812
155Nuclear cataract (HP:0100018)1.67488504
156Facial diplegia (HP:0001349)1.67322810
157Ulnar deviation of the wrist (HP:0003049)1.67145498
158Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.66901280
159Conjunctival telangiectasia (HP:0000524)1.66781859
160Abnormal cartilage morphology (HP:0002763)1.66547114
161Ulnar bowing (HP:0003031)1.65304814
162High pitched voice (HP:0001620)1.65084849
163Epidermoid cyst (HP:0200040)1.64987186
164Tetraparesis (HP:0002273)1.64605815
165Episodic fever (HP:0001954)1.64241927
166Scapular winging (HP:0003691)1.63184177
167Increased variability in muscle fiber diameter (HP:0003557)1.62322472
168Polycythemia (HP:0001901)1.61678219
169Progressive inability to walk (HP:0002505)1.60563641
170Cellulitis (HP:0100658)1.60541272
171Hypolipoproteinemia (HP:0010981)1.58868485
172Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.58663671
173Hemorrhage of the eye (HP:0011885)1.57990453
174Peripheral demyelination (HP:0011096)1.57976713
175Abnormality of the lumbar spine (HP:0100712)1.57734306
176Wrist flexion contracture (HP:0001239)1.56425501
177Achilles tendon contracture (HP:0001771)1.56276216
178Abnormality of the Achilles tendon (HP:0005109)1.54753858
179Subcapsular cataract (HP:0000523)1.54469897
180Skin nodule (HP:0200036)1.54392433
181Muscle fiber splitting (HP:0003555)1.53879111
182Coarse hair (HP:0002208)1.53359141
183Metaphyseal cupping (HP:0003021)1.53242998
184Axonal loss (HP:0003447)1.52778603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.16632941
2TRIB33.84854921
3CAMK1D3.68178350
4LATS13.50510212
5CDK123.33347401
6RIPK43.05099884
7TGFBR22.71589528
8IRAK22.62848535
9LATS22.57662670
10PIK3CG2.45878397
11CAMK1G2.28801153
12PKN22.20611163
13STK32.11358702
14IRAK42.07259818
15STK38L2.05109759
16YES12.01746514
17MAP3K131.99654642
18STK101.88693769
19TTN1.74907140
20EEF2K1.70150183
21MAP3K141.70143264
22ERN11.69023822
23KSR11.68027543
24NEK21.67944076
25PRPF4B1.65988152
26PDGFRA1.64170193
27CSF1R1.63019650
28RIPK11.61581303
29TIE11.56897396
30CDK91.50600624
31ERBB31.49808137
32BMX1.45377601
33MAP3K101.43706909
34MAP3K51.43510322
35SIK11.42949525
36STK241.40882053
37NEK91.39222663
38CDK61.38779851
39PINK11.36144715
40PHKG21.34556391
41PHKG11.34556391
42FES1.25907882
43FGFR31.25816949
44TYK21.23494162
45MAP2K41.22331965
46PTK61.22249539
47MAP3K21.21439331
48SGK31.21335338
49CDK41.20779739
50RAF11.17412960
51TTK1.17146914
52MTOR1.15123757
53PDK41.14614595
54PDK31.14614595
55ACVR1B1.13952574
56BRD41.11457273
57PDGFRB1.09695926
58MARK31.09550716
59SGK21.08560401
60MOS1.08533652
61PAK41.07944671
62CDC71.05650127
63PDK21.05378150
64FGFR41.04226847
65SIK30.98983832
66DMPK0.98832280
67PRKAA20.96190934
68CSK0.92879466
69SYK0.90413598
70MAP4K10.87721524
71CAMKK20.87421809
72PAK20.86072897
73NUAK10.84209783
74PDK10.84158041
75JAK10.83773985
76TNIK0.83384422
77NEK60.82255019
78MAP2K30.81691989
79NME10.81281856
80TRPM70.80909716
81RPS6KA40.80682738
82MST40.80034560
83SCYL20.79452433
84NLK0.79314489
85JAK30.79161028
86TYRO30.77347314
87BLK0.77032900
88FGR0.74386665
89MAP3K10.74142452
90MAP3K60.73750821
91IRAK10.73543833
92MAP3K80.72787944
93MAP3K90.72286290
94LYN0.71545775
95RPS6KB10.71116392
96TAOK10.70756703
97TAOK30.70694544
98PRKAA10.70466334
99IKBKE0.70330908
100TNK20.69722768
101JAK20.68999106
102CDK70.64577315
103MELK0.64492222
104DYRK30.61687475
105BTK0.61421389
106STK40.58919243
107MET0.58892762
108CAMK40.58846226
109FLT30.58713474
110ZAP700.58397561
111RET0.57683942
112MAPK70.57563876
113LRRK20.57293923
114GRK60.57122053
115ABL10.56926843
116MAP3K30.55816547
117ERBB40.55765804
118BRSK20.55552643
119STK380.55107398
120PNCK0.54943425
121CHEK20.53195303
122EIF2AK30.53039286
123KSR20.51571353
124KIT0.51200873
125PTK2B0.51007623
126PRKG10.49952110
127TBK10.49075305
128BCKDK0.49014972
129STK110.48818351
130ABL20.48330122
131HCK0.47758591
132EPHA30.44960473
133WNK10.44378048
134DDR20.43944252
135PLK10.42720050
136MAP3K70.42491484
137MAPK120.42207436
138TEC0.41969451
139ICK0.41830746
140FGFR10.41732917
141PRKCQ0.41457734
142IGF1R0.41223849
143PTK20.41214526
144MAPK110.40579326
145EGFR0.40153526
146CDK80.39340653
147AURKB0.39061878
148CHUK0.38719294
149MATK0.37863199
150MARK20.37789264
151PRKD10.36900498
152LCK0.36772415
153PIM10.36386935
154FGFR20.34979366
155SGK10.33515533
156PRKD20.33515289
157PDPK10.33419368
158EPHB10.32834957
159MAPK100.31675555

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.81982577
2PPAR signaling pathway_Homo sapiens_hsa033202.65598411
3Vitamin B6 metabolism_Homo sapiens_hsa007502.00100575
4Fatty acid biosynthesis_Homo sapiens_hsa000611.97510032
5Fatty acid degradation_Homo sapiens_hsa000711.85051824
6Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.84415787
7NOD-like receptor signaling pathway_Homo sapiens_hsa046211.83826542
8Complement and coagulation cascades_Homo sapiens_hsa046101.80953336
9Fatty acid metabolism_Homo sapiens_hsa012121.72990488
10Propanoate metabolism_Homo sapiens_hsa006401.66966730
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58691064
12Phagosome_Homo sapiens_hsa041451.55667960
13Chemokine signaling pathway_Homo sapiens_hsa040621.54852406
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54362674
15Lysine degradation_Homo sapiens_hsa003101.54228346
16Nitrogen metabolism_Homo sapiens_hsa009101.45487306
17Adipocytokine signaling pathway_Homo sapiens_hsa049201.41749374
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.38488315
19Adherens junction_Homo sapiens_hsa045201.37090687
20AMPK signaling pathway_Homo sapiens_hsa041521.35281546
21T cell receptor signaling pathway_Homo sapiens_hsa046601.34533006
22Influenza A_Homo sapiens_hsa051641.32652473
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30043526
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27742077
25Insulin resistance_Homo sapiens_hsa049311.27438347
26Small cell lung cancer_Homo sapiens_hsa052221.26984931
27mTOR signaling pathway_Homo sapiens_hsa041501.26757731
28Chronic myeloid leukemia_Homo sapiens_hsa052201.22552883
29Inositol phosphate metabolism_Homo sapiens_hsa005621.21758397
30Lysosome_Homo sapiens_hsa041421.21352864
31Glycerolipid metabolism_Homo sapiens_hsa005611.21035777
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18255067
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14144843
34Osteoclast differentiation_Homo sapiens_hsa043801.12066699
35Graft-versus-host disease_Homo sapiens_hsa053321.11732885
36MicroRNAs in cancer_Homo sapiens_hsa052061.10128457
37TGF-beta signaling pathway_Homo sapiens_hsa043501.09792746
38Cell cycle_Homo sapiens_hsa041101.09176690
39Pancreatic cancer_Homo sapiens_hsa052121.06904629
40Hematopoietic cell lineage_Homo sapiens_hsa046401.06521204
41Caffeine metabolism_Homo sapiens_hsa002321.05990473
42Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04391281
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03309622
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02102138
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.01927732
46Leishmaniasis_Homo sapiens_hsa051401.00963176
47Sphingolipid signaling pathway_Homo sapiens_hsa040711.00938530
48Non-homologous end-joining_Homo sapiens_hsa034501.00676594
49Allograft rejection_Homo sapiens_hsa053300.98963173
50Focal adhesion_Homo sapiens_hsa045100.98819926
51Viral myocarditis_Homo sapiens_hsa054160.98170087
52Antigen processing and presentation_Homo sapiens_hsa046120.96298185
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95695389
54Carbon metabolism_Homo sapiens_hsa012000.95395362
55Autoimmune thyroid disease_Homo sapiens_hsa053200.95008033
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93468968
57Proteoglycans in cancer_Homo sapiens_hsa052050.92936161
58Pertussis_Homo sapiens_hsa051330.92640358
59Toxoplasmosis_Homo sapiens_hsa051450.92484647
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.92369721
61Circadian rhythm_Homo sapiens_hsa047100.91490313
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.90466767
63Thyroid cancer_Homo sapiens_hsa052160.90334877
64Insulin signaling pathway_Homo sapiens_hsa049100.89411588
65Pentose phosphate pathway_Homo sapiens_hsa000300.87105631
66Regulation of autophagy_Homo sapiens_hsa041400.86994274
67ErbB signaling pathway_Homo sapiens_hsa040120.85790468
68B cell receptor signaling pathway_Homo sapiens_hsa046620.84085589
69Prolactin signaling pathway_Homo sapiens_hsa049170.83785212
70Hepatitis C_Homo sapiens_hsa051600.82894845
71Arginine biosynthesis_Homo sapiens_hsa002200.81928937
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80856929
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80702353
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79899220
75Choline metabolism in cancer_Homo sapiens_hsa052310.79761446
76Glioma_Homo sapiens_hsa052140.78985327
77Apoptosis_Homo sapiens_hsa042100.78448653
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78046148
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77058346
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77047898
81TNF signaling pathway_Homo sapiens_hsa046680.76448007
82HIF-1 signaling pathway_Homo sapiens_hsa040660.76419664
83ECM-receptor interaction_Homo sapiens_hsa045120.76178538
84Amoebiasis_Homo sapiens_hsa051460.75844563
85GnRH signaling pathway_Homo sapiens_hsa049120.75443645
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74764637
87Acute myeloid leukemia_Homo sapiens_hsa052210.74631447
88Renal cell carcinoma_Homo sapiens_hsa052110.74389469
89Notch signaling pathway_Homo sapiens_hsa043300.73882261
90FoxO signaling pathway_Homo sapiens_hsa040680.72388605
91p53 signaling pathway_Homo sapiens_hsa041150.71817585
92Tuberculosis_Homo sapiens_hsa051520.71432888
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71086094
94Other glycan degradation_Homo sapiens_hsa005110.69668638
95beta-Alanine metabolism_Homo sapiens_hsa004100.69481897
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69065270
97Salmonella infection_Homo sapiens_hsa051320.68729652
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67596409
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67233326
100Colorectal cancer_Homo sapiens_hsa052100.66411226
101Herpes simplex infection_Homo sapiens_hsa051680.66196789
102Hepatitis B_Homo sapiens_hsa051610.66095340
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.66041831
104Biosynthesis of amino acids_Homo sapiens_hsa012300.65509561
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64928504
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.64267692
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.63017872
108HTLV-I infection_Homo sapiens_hsa051660.62970264
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62557198
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61622721
111Dorso-ventral axis formation_Homo sapiens_hsa043200.61430948
112Shigellosis_Homo sapiens_hsa051310.60801918
113Legionellosis_Homo sapiens_hsa051340.59857848
114Viral carcinogenesis_Homo sapiens_hsa052030.59001463
115Hippo signaling pathway_Homo sapiens_hsa043900.58226258
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57886571
117African trypanosomiasis_Homo sapiens_hsa051430.55762302
118Non-small cell lung cancer_Homo sapiens_hsa052230.54946089
119Malaria_Homo sapiens_hsa051440.53981920
120Long-term potentiation_Homo sapiens_hsa047200.53854130
121Prostate cancer_Homo sapiens_hsa052150.53618330
122Type I diabetes mellitus_Homo sapiens_hsa049400.53073084
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52885430
124Endometrial cancer_Homo sapiens_hsa052130.52379820
125Endocytosis_Homo sapiens_hsa041440.51374856
126Rap1 signaling pathway_Homo sapiens_hsa040150.51174476
127RNA transport_Homo sapiens_hsa030130.51134423
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.50660162
129Fat digestion and absorption_Homo sapiens_hsa049750.50618698
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50537401
131Platelet activation_Homo sapiens_hsa046110.50442368
132VEGF signaling pathway_Homo sapiens_hsa043700.50256311
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50191332
134Tryptophan metabolism_Homo sapiens_hsa003800.49838094
135Pathways in cancer_Homo sapiens_hsa052000.49363790
136Measles_Homo sapiens_hsa051620.48776459
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47816809
138ABC transporters_Homo sapiens_hsa020100.47632266
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.47194894
140Rheumatoid arthritis_Homo sapiens_hsa053230.46075260
141Type II diabetes mellitus_Homo sapiens_hsa049300.45921740
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43484240
143Primary immunodeficiency_Homo sapiens_hsa053400.42739885

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »