OSBPL1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.82985437
2central nervous system myelination (GO:0022010)5.82985437
3fatty acid elongation (GO:0030497)4.88251292
4presynaptic membrane assembly (GO:0097105)4.82420700
5presynaptic membrane organization (GO:0097090)4.65016698
6sodium ion export (GO:0071436)4.46093714
7glutamate secretion (GO:0014047)4.39214814
8neuronal action potential propagation (GO:0019227)4.36859086
9regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.26185408
10neuron cell-cell adhesion (GO:0007158)4.16328563
11synaptic vesicle exocytosis (GO:0016079)3.92423308
12cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.91606131
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.87463867
14regulation of cell communication by electrical coupling (GO:0010649)3.87184540
15myelination (GO:0042552)3.79907293
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.78902339
17long-chain fatty acid biosynthetic process (GO:0042759)3.78405927
18axon ensheathment (GO:0008366)3.77193790
19ensheathment of neurons (GO:0007272)3.77193790
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.77010034
21cerebellar granule cell differentiation (GO:0021707)3.73370152
22regulation of synaptic vesicle exocytosis (GO:2000300)3.66224213
23synaptic vesicle maturation (GO:0016188)3.65479351
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.61616790
25neurotransmitter-gated ion channel clustering (GO:0072578)3.52895729
26cell communication by electrical coupling (GO:0010644)3.50673546
27negative regulation of neurotransmitter transport (GO:0051589)3.50311418
28synaptic vesicle docking involved in exocytosis (GO:0016081)3.47818693
29amino acid import (GO:0043090)3.47416626
30protein localization to synapse (GO:0035418)3.42846038
31potassium ion import (GO:0010107)3.42399594
32vocalization behavior (GO:0071625)3.41108811
33sarcoplasmic reticulum calcium ion transport (GO:0070296)3.40667399
34negative regulation of neurotransmitter secretion (GO:0046929)3.38049217
35positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.37613934
36potassium ion homeostasis (GO:0055075)3.36641560
37L-amino acid import (GO:0043092)3.34378314
38regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.34300360
39positive regulation of dendritic spine development (GO:0060999)3.28816225
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.25287902
41neuromuscular synaptic transmission (GO:0007274)3.22798505
42locomotory exploration behavior (GO:0035641)3.22610940
43regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.22609352
44gamma-aminobutyric acid transport (GO:0015812)3.21056171
45positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.20801011
46positive regulation of synapse maturation (GO:0090129)3.20310359
47neuromuscular process controlling balance (GO:0050885)3.20221723
48transmission of nerve impulse (GO:0019226)3.17038436
49membrane depolarization during action potential (GO:0086010)3.14208844
50regulation of glutamate receptor signaling pathway (GO:1900449)3.12309887
51regulation of synaptic vesicle transport (GO:1902803)3.10119989
52L-phenylalanine catabolic process (GO:0006559)3.09618272
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.09618272
54cell communication involved in cardiac conduction (GO:0086065)3.07950169
55regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.06986713
56regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.06229923
57neuron-neuron synaptic transmission (GO:0007270)3.05722679
58synaptic transmission, glutamatergic (GO:0035249)3.05336769
59ionotropic glutamate receptor signaling pathway (GO:0035235)3.04481393
60regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.04454534
61cellular sodium ion homeostasis (GO:0006883)3.03901108
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.03302798
63detection of calcium ion (GO:0005513)2.99757052
64response to methylmercury (GO:0051597)2.99652492
65regulation of voltage-gated calcium channel activity (GO:1901385)2.99513591
66regulation of neurotransmitter levels (GO:0001505)2.96937886
67regulation of synapse structural plasticity (GO:0051823)2.96468855
68acidic amino acid transport (GO:0015800)2.93281398
69regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.92541618
70postsynaptic membrane organization (GO:0001941)2.92043626
71synaptic vesicle endocytosis (GO:0048488)2.90426761
72glutamate receptor signaling pathway (GO:0007215)2.90049524
73adult walking behavior (GO:0007628)2.88889003
74glycerophospholipid catabolic process (GO:0046475)2.86412418
75apical protein localization (GO:0045176)2.85771675
76negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.84432828
77long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.83015557
78regulation of neuronal synaptic plasticity (GO:0048168)2.81255414
79regulation of excitatory postsynaptic membrane potential (GO:0060079)2.80566442
80long-term synaptic potentiation (GO:0060291)2.78930294
81neuron recognition (GO:0008038)2.78669363
82neurotransmitter secretion (GO:0007269)2.77745696
83positive regulation of dendritic spine morphogenesis (GO:0061003)2.77686340
84negative regulation of protein localization to cell surface (GO:2000009)2.77661972
85behavioral response to cocaine (GO:0048148)2.77620534
86positive regulation of membrane potential (GO:0045838)2.77467036
87regulation of membrane repolarization (GO:0060306)2.73244794
88regulation of synapse maturation (GO:0090128)2.72796400
89proline transport (GO:0015824)2.72648635
90neurotransmitter uptake (GO:0001504)2.72188608
91establishment of mitochondrion localization (GO:0051654)2.71705774
92layer formation in cerebral cortex (GO:0021819)2.71253610
93regulation of long-term neuronal synaptic plasticity (GO:0048169)2.69271494
94L-glutamate transport (GO:0015813)2.69216378
95fatty-acyl-CoA biosynthetic process (GO:0046949)2.68001770
96very long-chain fatty acid metabolic process (GO:0000038)2.67800067
97cholesterol biosynthetic process (GO:0006695)2.67668209
98regulation of postsynaptic membrane potential (GO:0060078)2.66117259
99substantia nigra development (GO:0021762)2.65723275
100L-phenylalanine metabolic process (GO:0006558)2.65155517
101erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.65155517
102membrane depolarization (GO:0051899)2.64479624
103long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.62798112
104cardiac muscle contraction (GO:0060048)2.62729827
105C4-dicarboxylate transport (GO:0015740)2.62100017
106membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62044050
107regulation of calcium ion transmembrane transporter activity (GO:1901019)2.60970326
108regulation of calcium ion transmembrane transport (GO:1903169)2.60970326
109muscle filament sliding (GO:0030049)2.60419688
110actin-myosin filament sliding (GO:0033275)2.60419688
111relaxation of muscle (GO:0090075)2.60286746
112regulation of neurotransmitter secretion (GO:0046928)2.59764945
113membrane assembly (GO:0071709)2.59489907
114regulation of actin filament-based movement (GO:1903115)2.59178223
115regulation of synaptic plasticity (GO:0048167)2.58718260
116neuromuscular process (GO:0050905)2.57908524
117activation of protein kinase A activity (GO:0034199)2.57855797
118positive regulation of potassium ion transport (GO:0043268)2.57303025
119regulation of dendritic spine development (GO:0060998)2.54668102
120negative regulation of dendrite morphogenesis (GO:0050774)2.54364345
121neuronal ion channel clustering (GO:0045161)2.54204890
122regulation of relaxation of muscle (GO:1901077)2.53590236
123fatty-acyl-CoA metabolic process (GO:0035337)2.52859682
124mechanosensory behavior (GO:0007638)2.52673978
125neurotransmitter transport (GO:0006836)2.51189828
126dendritic spine morphogenesis (GO:0060997)2.50775386
127auditory behavior (GO:0031223)2.49288478
128oligodendrocyte differentiation (GO:0048709)2.48894439
129axonal fasciculation (GO:0007413)2.48205507
130thioester biosynthetic process (GO:0035384)2.46862057
131acyl-CoA biosynthetic process (GO:0071616)2.46862057
132regulation of dendritic spine morphogenesis (GO:0061001)2.44984975
133cellular potassium ion homeostasis (GO:0030007)2.43266007
134regulation of synaptic transmission, glutamatergic (GO:0051966)2.42662582
135negative regulation of axonogenesis (GO:0050771)2.42156784
136cellular response to epinephrine stimulus (GO:0071872)2.41960607
137myelin maintenance (GO:0043217)2.41553355
138regulation of glutamate secretion (GO:0014048)2.41490398
139G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.40471646
140negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.40267904
141regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40246389
142regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.39953682
143dendrite morphogenesis (GO:0048813)2.39382777
144exploration behavior (GO:0035640)2.38118258
145neuron remodeling (GO:0016322)2.37027365
146regulation of neurotransmitter transport (GO:0051588)2.35893432
147membrane hyperpolarization (GO:0060081)2.35430579
148sterol biosynthetic process (GO:0016126)2.34839183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.00749370
2EZH2_22144423_ChIP-Seq_EOC_Human3.82879337
3TAF15_26573619_Chip-Seq_HEK293_Human2.80939846
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71829870
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69411695
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52094989
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25306344
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25306344
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20034496
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17096203
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14397625
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12237628
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12065891
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.06763172
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04378819
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.01400662
17DROSHA_22980978_ChIP-Seq_HELA_Human1.96460208
18SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.94458140
19REST_21632747_ChIP-Seq_MESCs_Mouse1.93000356
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90968646
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87790650
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87124541
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.86586224
24* RARB_27405468_Chip-Seq_BRAIN_Mouse1.82327507
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81064547
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78421409
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.72529250
28AR_21572438_ChIP-Seq_LNCaP_Human1.63542657
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62513937
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.62464581
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60199215
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.56875437
33P300_19829295_ChIP-Seq_ESCs_Human1.55925862
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.53563041
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51337010
36SMAD4_21799915_ChIP-Seq_A2780_Human1.50259355
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47548289
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44689113
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43069600
40VDR_22108803_ChIP-Seq_LS180_Human1.43004684
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42268086
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.41427796
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40498116
44ER_23166858_ChIP-Seq_MCF-7_Human1.38292093
45FUS_26573619_Chip-Seq_HEK293_Human1.36583438
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36371148
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35172667
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32496514
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31987398
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.28036319
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27387590
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26416634
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26211166
54* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24724661
55RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24413949
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.24339412
57STAT3_23295773_ChIP-Seq_U87_Human1.24084905
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23916909
59* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23757072
60* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21860692
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21813882
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19902882
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.18621577
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17961945
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16868512
66AR_19668381_ChIP-Seq_PC3_Human1.16095334
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15755604
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15755604
69SOX9_26525672_Chip-Seq_HEART_Mouse1.14103548
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12329837
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.12088536
72TCF4_23295773_ChIP-Seq_U87_Human1.11784003
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11313254
74LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10524603
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09988083
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09642772
77AR_25329375_ChIP-Seq_VCAP_Human1.09637628
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.09209234
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08805416
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08711881
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08302752
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07841692
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06889510
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.03217215
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02035833
86CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01791646
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01249725
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01249725
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00766147
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00322614
91AHR_22903824_ChIP-Seq_MCF-7_Human1.00086262
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99163285
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99131118
94* FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98235056
95* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97975812
96HTT_18923047_ChIP-ChIP_STHdh_Human0.97827229
97RING1B_27294783_Chip-Seq_NPCs_Mouse0.97767561
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.97333736
99WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97246527
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97229490
101RNF2_27304074_Chip-Seq_NSC_Mouse0.96796323
102PRDM14_20953172_ChIP-Seq_ESCs_Human0.96598789
103CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96430436
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95944430
105IGF1R_20145208_ChIP-Seq_DFB_Human0.95200094
106RING1B_27294783_Chip-Seq_ESCs_Mouse0.94829006
107CMYC_18555785_Chip-Seq_ESCs_Mouse0.93867468
108ISL1_27105846_Chip-Seq_CPCs_Mouse0.93519331
109RUNX2_22187159_ChIP-Seq_PCA_Human0.93288021
110SMAD4_21741376_ChIP-Seq_EPCs_Human0.92962904
111TP53_18474530_ChIP-ChIP_U2OS_Human0.92537271
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92000199
113* LXR_22158963_ChIP-Seq_LIVER_Mouse0.91963242
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91204149
115TP53_16413492_ChIP-PET_HCT116_Human0.90769800
116KDM2B_26808549_Chip-Seq_REH_Human0.90761934
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90225498
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89733881
119* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89357463
120OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89059004
121TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88980264
122* TET1_21490601_ChIP-Seq_MESCs_Mouse0.88523948
123RXR_22158963_ChIP-Seq_LIVER_Mouse0.87714788
124TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87712152
125TAL1_26923725_Chip-Seq_HPCs_Mouse0.87676301
126E2F1_18555785_Chip-Seq_ESCs_Mouse0.87651147
127P53_22387025_ChIP-Seq_ESCs_Mouse0.86795852
128EP300_21415370_ChIP-Seq_HL-1_Mouse0.86735093
129SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86346101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.04304818
2MP0004859_abnormal_synaptic_plasticity4.32352470
3MP0004270_analgesia3.78000484
4MP0003635_abnormal_synaptic_transmissio3.09310693
5MP0009745_abnormal_behavioral_response2.91888246
6MP0002064_seizures2.90742059
7MP0000920_abnormal_myelination2.83143989
8MP0009046_muscle_twitch2.74479223
9MP0002272_abnormal_nervous_system2.67147453
10MP0003329_amyloid_beta_deposits2.66737241
11MP0001486_abnormal_startle_reflex2.57372645
12MP0002063_abnormal_learning/memory/cond2.45391722
13MP0008875_abnormal_xenobiotic_pharmacok2.30597355
14MP0001968_abnormal_touch/_nociception2.25723105
15MP0002734_abnormal_mechanical_nocicepti2.22366298
16MP0004885_abnormal_endolymph2.20008005
17MP0002572_abnormal_emotion/affect_behav2.19943659
18MP0003690_abnormal_glial_cell2.14611862
19MP0005423_abnormal_somatic_nervous2.12427285
20MP0000749_muscle_degeneration1.89031044
21MP0001440_abnormal_grooming_behavior1.88947927
22MP0002139_abnormal_hepatobiliary_system1.83090238
23MP0001905_abnormal_dopamine_level1.82837445
24MP0002067_abnormal_sensory_capabilities1.78867839
25MP0001984_abnormal_olfaction1.75219803
26MP0000778_abnormal_nervous_system1.74967890
27MP0004142_abnormal_muscle_tone1.71771932
28MP0002736_abnormal_nociception_after1.70943231
29MP0004742_abnormal_vestibular_system1.70048641
30MP0001529_abnormal_vocalization1.67299782
31MP0001501_abnormal_sleep_pattern1.60980410
32MP0005386_behavior/neurological_phenoty1.59783057
33MP0004924_abnormal_behavior1.59783057
34MP0005085_abnormal_gallbladder_physiolo1.56116920
35MP0009379_abnormal_foot_pigmentation1.54902054
36MP0001485_abnormal_pinna_reflex1.52784266
37MP0009780_abnormal_chondrocyte_physiolo1.52516725
38MP0002638_abnormal_pupillary_reflex1.50993525
39MP0003195_calcinosis1.50122770
40MP0008569_lethality_at_weaning1.50055199
41MP0003646_muscle_fatigue1.49843027
42MP0001970_abnormal_pain_threshold1.46952339
43MP0002733_abnormal_thermal_nociception1.46499876
44MP0003633_abnormal_nervous_system1.45368057
45MP0004147_increased_porphyrin_level1.45124522
46MP0000604_amyloidosis1.45103963
47MP0002735_abnormal_chemical_nociception1.44667662
48MP0005360_urolithiasis1.43723146
49MP0002229_neurodegeneration1.43365120
50MP0003631_nervous_system_phenotype1.37833209
51MP0000955_abnormal_spinal_cord1.35324061
52MP0005365_abnormal_bile_salt1.35209045
53MP0002066_abnormal_motor_capabilities/c1.33848540
54MP0003632_abnormal_nervous_system1.30177369
55MP0003806_abnormal_nucleotide_metabolis1.30041630
56MP0004215_abnormal_myocardial_fiber1.29969061
57MP0003634_abnormal_glial_cell1.29219187
58MP0002882_abnormal_neuron_morphology1.28705325
59MP0005646_abnormal_pituitary_gland1.28248346
60MP0002822_catalepsy1.28179477
61MP0002557_abnormal_social/conspecific_i1.25374456
62MP0004043_abnormal_pH_regulation1.24702646
63MP0003879_abnormal_hair_cell1.20656298
64MP0005551_abnormal_eye_electrophysiolog1.18605367
65MP0005620_abnormal_muscle_contractility1.18474963
66MP0001299_abnormal_eye_distance/1.17307012
67MP0004084_abnormal_cardiac_muscle1.17093962
68MP0004145_abnormal_muscle_electrophysio1.16076941
69MP0005171_absent_coat_pigmentation1.14643218
70MP0000579_abnormal_nail_morphology1.12135377
71MP0001963_abnormal_hearing_physiology1.11461181
72MP0001502_abnormal_circadian_rhythm1.11253741
73MP0000566_synostosis1.09173415
74MP0003950_abnormal_plasma_membrane1.08025578
75MP0002837_dystrophic_cardiac_calcinosis1.07594269
76MP0002184_abnormal_innervation1.05464786
77MP0005410_abnormal_fertilization1.04280622
78MP0004811_abnormal_neuron_physiology1.03835616
79MP0004087_abnormal_muscle_fiber1.01297323
80MP0005670_abnormal_white_adipose0.99809693
81MP0003787_abnormal_imprinting0.94968918
82MP0003136_yellow_coat_color0.93962337
83MP0008874_decreased_physiological_sensi0.93866827
84MP0010329_abnormal_lipoprotein_level0.92729860
85MP0000759_abnormal_skeletal_muscle0.91441704
86MP0010030_abnormal_orbit_morphology0.91143291
87MP0010386_abnormal_urinary_bladder0.90165481
88MP0002118_abnormal_lipid_homeostasis0.87137689
89MP0002106_abnormal_muscle_physiology0.86723233
90MP0002152_abnormal_brain_morphology0.84924723
91MP0006276_abnormal_autonomic_nervous0.84543513
92MP0002269_muscular_atrophy0.83966464
93MP0008872_abnormal_physiological_respon0.83911660
94MP0005535_abnormal_body_temperature0.83798121
95MP0001346_abnormal_lacrimal_gland0.83360617
96MP0005409_darkened_coat_color0.82448411
97MP0005369_muscle_phenotype0.82205997
98MP0002752_abnormal_somatic_nervous0.81702158
99MP0005623_abnormal_meninges_morphology0.80717103
100MP0002972_abnormal_cardiac_muscle0.79889613
101MP0005332_abnormal_amino_acid0.79416069
102MP0001177_atelectasis0.78567429
103MP0002090_abnormal_vision0.77953183
104MP0005187_abnormal_penis_morphology0.77605104
105MP0000751_myopathy0.75805372
106MP0001188_hyperpigmentation0.75328492
107MP0000569_abnormal_digit_pigmentation0.75044010
108MP0003122_maternal_imprinting0.73967325
109MP0002876_abnormal_thyroid_physiology0.72197739
110MP0004484_altered_response_of0.71086072
111MP0005451_abnormal_body_composition0.71006826
112MP0005083_abnormal_biliary_tract0.70928200
113MP0000747_muscle_weakness0.70800358
114MP0002069_abnormal_eating/drinking_beha0.70443256
115MP0009840_abnormal_foam_cell0.69825149
116MP0005499_abnormal_olfactory_system0.69523254
117MP0005394_taste/olfaction_phenotype0.69523254
118MP0004036_abnormal_muscle_relaxation0.67915100
119MP0005167_abnormal_blood-brain_barrier0.67638734
120MP0005174_abnormal_tail_pigmentation0.67299324
121MP0004085_abnormal_heartbeat0.67254145
122MP0006138_congestive_heart_failure0.67034523
123MP0005584_abnormal_enzyme/coenzyme_acti0.66819481
124MP0004858_abnormal_nervous_system0.63064086
125MP0004130_abnormal_muscle_cell0.62567600
126MP0000026_abnormal_inner_ear0.61404035
127MP0003868_abnormal_feces_composition0.61276127
128MP0003137_abnormal_impulse_conducting0.59909873
129MP0002108_abnormal_muscle_morphology0.59876188
130MP0003283_abnormal_digestive_organ0.59636046
131MP0001664_abnormal_digestion0.58975109
132MP0000639_abnormal_adrenal_gland0.58938156

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.73760676
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.98070771
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.98070771
4Neurofibrillary tangles (HP:0002185)4.66918118
5Hyperventilation (HP:0002883)4.48696160
6Epileptic encephalopathy (HP:0200134)4.38181189
7Myokymia (HP:0002411)4.36269312
8Muscle fiber inclusion bodies (HP:0100299)4.29476264
9Nemaline bodies (HP:0003798)4.26575657
10Abnormality of the corticospinal tract (HP:0002492)4.20214572
11Atonic seizures (HP:0010819)4.16433942
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.08852040
13Focal seizures (HP:0007359)3.87084430
14Sensory axonal neuropathy (HP:0003390)3.81541268
15Exercise-induced muscle cramps (HP:0003710)3.76787923
16Cerebral inclusion bodies (HP:0100314)3.74580875
17Type 1 muscle fiber predominance (HP:0003803)3.44025076
18Bundle branch block (HP:0011710)3.37851925
19Scanning speech (HP:0002168)3.33028363
20Spastic gait (HP:0002064)3.27390267
21Insidious onset (HP:0003587)3.24111220
22Termporal pattern (HP:0011008)3.24111220
23Dysmetria (HP:0001310)3.21016047
24Broad-based gait (HP:0002136)3.20403068
25Supranuclear gaze palsy (HP:0000605)3.13945766
26Exercise-induced myalgia (HP:0003738)3.10616845
27Intention tremor (HP:0002080)3.07326096
28Absence seizures (HP:0002121)3.06855748
29Dialeptic seizures (HP:0011146)3.03187807
30Hyporeflexia of lower limbs (HP:0002600)3.01848835
31Diplopia (HP:0000651)2.82357628
32Abnormality of binocular vision (HP:0011514)2.82357628
33Muscle fiber splitting (HP:0003555)2.77778554
34Gaze-evoked nystagmus (HP:0000640)2.77704591
35Peripheral hypomyelination (HP:0007182)2.76914943
36Generalized tonic-clonic seizures (HP:0002069)2.76499806
37Ankle clonus (HP:0011448)2.76039002
38Abnormality of glycolysis (HP:0004366)2.71950401
39Increased serum pyruvate (HP:0003542)2.71950401
40Myotonia (HP:0002486)2.67219723
41Action tremor (HP:0002345)2.65369073
42Visual hallucinations (HP:0002367)2.63699182
43Poor eye contact (HP:0000817)2.63656879
44Febrile seizures (HP:0002373)2.63019953
45Abnormality of aromatic amino acid family metabolism (HP:0004338)2.56231051
46Pheochromocytoma (HP:0002666)2.55030788
47Muscle hypertrophy of the lower extremities (HP:0008968)2.52724051
48Dysdiadochokinesis (HP:0002075)2.49541856
49Sudden death (HP:0001699)2.48945777
50Parakeratosis (HP:0001036)2.47042318
51EMG: myopathic abnormalities (HP:0003458)2.44885093
52Distal arthrogryposis (HP:0005684)2.43568950
53Heart block (HP:0012722)2.41625852
54Intrahepatic cholestasis (HP:0001406)2.36672867
55Hyperlipoproteinemia (HP:0010980)2.34932970
56Abnormal social behavior (HP:0012433)2.32570553
57Impaired social interactions (HP:0000735)2.32570553
58Difficulty running (HP:0009046)2.31625440
59Onion bulb formation (HP:0003383)2.31494782
60Progressive cerebellar ataxia (HP:0002073)2.31188229
61Calf muscle hypertrophy (HP:0008981)2.30180310
62Akinesia (HP:0002304)2.28606758
63Urinary urgency (HP:0000012)2.28285869
64Generalized myoclonic seizures (HP:0002123)2.28019552
65Neuroendocrine neoplasm (HP:0100634)2.27547693
66Impaired vibration sensation in the lower limbs (HP:0002166)2.25664744
67Abnormal gallbladder physiology (HP:0012438)2.25078897
68Cholecystitis (HP:0001082)2.25078897
69Clumsiness (HP:0002312)2.23697580
70Cerebral hemorrhage (HP:0001342)2.21896924
71Urinary bladder sphincter dysfunction (HP:0002839)2.19512779
72Retinal dysplasia (HP:0007973)2.17381960
73Abnormal atrioventricular conduction (HP:0005150)2.16174477
74Leukodystrophy (HP:0002415)2.15212696
75Mutism (HP:0002300)2.14422062
76Anxiety (HP:0000739)2.13650446
77Excessive salivation (HP:0003781)2.12777556
78Drooling (HP:0002307)2.12777556
79Lower limb muscle weakness (HP:0007340)2.12538200
80Rimmed vacuoles (HP:0003805)2.12295492
81Blue irides (HP:0000635)2.11847139
82Muscle stiffness (HP:0003552)2.09935902
83Thickened helices (HP:0000391)2.09403335
84Turricephaly (HP:0000262)2.07406889
85Frequent falls (HP:0002359)2.05750246
86Cerebral hypomyelination (HP:0006808)2.05106149
87Abnormality of the calf musculature (HP:0001430)2.04418842
88Methylmalonic acidemia (HP:0002912)2.04123223
89Inability to walk (HP:0002540)2.03639127
90Progressive inability to walk (HP:0002505)2.02422200
91Postural instability (HP:0002172)2.02245639
92Deep venous thrombosis (HP:0002625)2.02166073
93Limb dystonia (HP:0002451)2.01542646
94Lower limb amyotrophy (HP:0007210)2.00097346
95Epileptiform EEG discharges (HP:0011182)1.99338732
96Tetraplegia (HP:0002445)1.98077709
97Annular pancreas (HP:0001734)1.96657756
98Absent speech (HP:0001344)1.96308261
99Morphological abnormality of the pyramidal tract (HP:0002062)1.94217793
100Torticollis (HP:0000473)1.94155116
101Poor speech (HP:0002465)1.94131260
102Myoglobinuria (HP:0002913)1.92309015
103Truncal ataxia (HP:0002078)1.92051526
104Abnormal eating behavior (HP:0100738)1.91303770
105Status epilepticus (HP:0002133)1.90876268
106Abnormality of the lower motor neuron (HP:0002366)1.87600439
107Sleep apnea (HP:0010535)1.87297397
108Abnormality of skeletal muscle fiber size (HP:0012084)1.85994661
109Abnormality of the left ventricular outflow tract (HP:0011103)1.85672793
110Subaortic stenosis (HP:0001682)1.85672793
111Clonus (HP:0002169)1.85146798
112EEG with generalized epileptiform discharges (HP:0011198)1.83520764
113Round ear (HP:0100830)1.82916603
114Xanthomatosis (HP:0000991)1.82719273
115Neck muscle weakness (HP:0000467)1.82264694
116Autoamputation (HP:0001218)1.81387647
117Calcaneovalgus deformity (HP:0001848)1.80804598
118Focal dystonia (HP:0004373)1.80438433
119Impaired vibratory sensation (HP:0002495)1.80277921
120Abnormality of saccadic eye movements (HP:0000570)1.79978666
121Increased variability in muscle fiber diameter (HP:0003557)1.78916353
122Spastic tetraparesis (HP:0001285)1.78638363
123Acute encephalopathy (HP:0006846)1.78468763
124Slow saccadic eye movements (HP:0000514)1.77867286
125Spastic paraparesis (HP:0002313)1.77452098
126Craniofacial dystonia (HP:0012179)1.77182976
127Prolonged partial thromboplastin time (HP:0003645)1.76929658
128Fair hair (HP:0002286)1.76414926
129Abnormality of the foot musculature (HP:0001436)1.76036693
130Acute necrotizing encephalopathy (HP:0006965)1.75930967
131Syncope (HP:0001279)1.73451377
132Rapidly progressive (HP:0003678)1.73295477
133Hemiparesis (HP:0001269)1.73187131
134Atrioventricular block (HP:0001678)1.73112434
135EMG: neuropathic changes (HP:0003445)1.72882723
136Hypsarrhythmia (HP:0002521)1.72353144
137Fetal akinesia sequence (HP:0001989)1.71947810
138Depression (HP:0000716)1.71694591
139Split foot (HP:0001839)1.71317813
140Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70848003
141Absent/shortened dynein arms (HP:0200106)1.70441300
142Dynein arm defect of respiratory motile cilia (HP:0012255)1.70441300
143Aplasia involving bones of the extremities (HP:0009825)1.70105092
144Aplasia involving bones of the upper limbs (HP:0009823)1.70105092
145Aplasia of the phalanges of the hand (HP:0009802)1.70105092
146Amblyopia (HP:0000646)1.70095707
147Foot dorsiflexor weakness (HP:0009027)1.70036138
148Atrial fibrillation (HP:0005110)1.69950636
149Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.69915260
150Hemiplegia (HP:0002301)1.68936512
151Incomplete penetrance (HP:0003829)1.67989513

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.10921864
2OXSR13.93120059
3STK393.78135471
4EPHA43.70654462
5CDK193.54903923
6OBSCN3.21191539
7DAPK22.69715484
8TNIK2.48068656
9NTRK32.21746068
10MAP3K42.17076710
11LATS21.99444257
12MAP2K71.94647495
13MAP3K91.94577399
14PAK61.89962635
15PRPF4B1.71473723
16MARK11.69962635
17NTRK11.59957991
18MAP2K41.54214271
19CCNB11.48732803
20PKN11.45351160
21WNK41.44973108
22BCR1.44286325
23FGFR21.38825913
24PNCK1.38596788
25MAPKAPK51.38365021
26SGK2231.32079455
27SGK4941.32079455
28PLK21.31558502
29CAMK2B1.31219626
30UHMK11.31155209
31MINK11.31049604
32CDK51.28144692
33WNK11.27186366
34EPHB11.26274386
35TTN1.22829257
36KSR21.17550864
37ARAF1.13494662
38NEK61.12629269
39CSNK1G21.10597294
40CAMK2A1.09704259
41RIPK11.08243113
42CAMKK21.03798231
43CSNK1G31.03554122
44RIPK41.01498683
45NTRK21.01113076
46DAPK11.01000258
47GRK50.98823897
48MAPK130.98453429
49CAMK2D0.98398682
50MET0.96761374
51MAP3K120.96423514
52ROCK20.94350761
53TYRO30.93465653
54FGR0.92700773
55CSNK1A1L0.92641971
56DMPK0.91711179
57PAK30.90544258
58CDK140.88182707
59MUSK0.87974345
60CAMK2G0.87590743
61PHKG20.85731645
62PHKG10.85731645
63PRKCG0.84582457
64CDK150.84407175
65ICK0.84203466
66CDK180.83550574
67BMPR20.82917063
68PINK10.82593561
69PDPK10.82454447
70CAMKK10.78524986
71MARK20.76130065
72MAP3K130.76043648
73MAPK70.74553240
74CDK11A0.72749846
75ADRBK20.70403589
76PBK0.70284690
77MAPK120.69972690
78STK110.69603981
79CSNK1G10.68774348
80MAP3K20.68119766
81CDC70.67684618
82MAPK100.67279400
83PRKCE0.65482543
84CAMK10.65372557
85PTK2B0.65160139
86BRAF0.64658741
87PDK10.64115154
88RPS6KA30.63922159
89KSR10.63177271
90CAMK40.62863950
91DAPK30.58252877
92MOS0.56156889
93AKT30.54632647
94ALK0.53824597
95LIMK10.52505812
96ROCK10.52237126
97PRKD30.51745001
98SGK30.51520809
99ERBB40.51262879
100BCKDK0.50326145
101SGK10.50200355
102CAMK1G0.49136813
103FES0.48901643
104DDR20.48243099
105RET0.46670308
106PIK3CA0.45066631
107TTK0.45008035
108PRKCH0.44993457
109PDK30.43882330
110PDK40.43882330
111PRKCQ0.43075941
112FYN0.43065941
113PRKACA0.42022003
114PRKG10.41652755
115DYRK1A0.41196604
116RAF10.39934173
117SGK20.39684927
118PLK30.39464444
119CSNK1E0.39168467
120PRKACB0.38819273
121PDK20.38563335
122NEK10.37363194
123STK38L0.36343367
124PAK20.36035396
125AKT20.35360475
126PRKCA0.34814800
127STK380.34595053
128PRKG20.33365859
129TIE10.33091225
130PRKDC0.32154608
131CSNK1A10.31604591
132GSK3B0.29025740

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55927872
2Fatty acid elongation_Homo sapiens_hsa000622.40102785
3Nicotine addiction_Homo sapiens_hsa050332.38129240
4Synaptic vesicle cycle_Homo sapiens_hsa047212.35901743
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.25483739
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.24256072
7Nitrogen metabolism_Homo sapiens_hsa009102.21518255
8Steroid biosynthesis_Homo sapiens_hsa001002.06856525
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93819151
10GABAergic synapse_Homo sapiens_hsa047271.88504407
11Glutamatergic synapse_Homo sapiens_hsa047241.88209031
12Butanoate metabolism_Homo sapiens_hsa006501.85350510
13Collecting duct acid secretion_Homo sapiens_hsa049661.78286074
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.77365145
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69674736
16Circadian entrainment_Homo sapiens_hsa047131.68119398
17Morphine addiction_Homo sapiens_hsa050321.64657286
18Dilated cardiomyopathy_Homo sapiens_hsa054141.53117696
19Sulfur metabolism_Homo sapiens_hsa009201.50903764
20Long-term potentiation_Homo sapiens_hsa047201.50255664
21Salivary secretion_Homo sapiens_hsa049701.49217969
22Oxidative phosphorylation_Homo sapiens_hsa001901.49176241
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48004808
24Amphetamine addiction_Homo sapiens_hsa050311.45983296
25Olfactory transduction_Homo sapiens_hsa047401.45336836
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31758678
27Propanoate metabolism_Homo sapiens_hsa006401.31704676
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29582222
29Dopaminergic synapse_Homo sapiens_hsa047281.25632822
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25336925
31Serotonergic synapse_Homo sapiens_hsa047261.24621891
32Melanogenesis_Homo sapiens_hsa049161.24621664
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24621182
34Ether lipid metabolism_Homo sapiens_hsa005651.21365562
35Long-term depression_Homo sapiens_hsa047301.21015965
36Gastric acid secretion_Homo sapiens_hsa049711.19993028
37Circadian rhythm_Homo sapiens_hsa047101.19524033
38Renin secretion_Homo sapiens_hsa049241.17390672
39Axon guidance_Homo sapiens_hsa043601.14428036
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12816529
41Arginine biosynthesis_Homo sapiens_hsa002201.11113203
42Fatty acid metabolism_Homo sapiens_hsa012121.11022994
43Taste transduction_Homo sapiens_hsa047421.10675315
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08855139
45Pyruvate metabolism_Homo sapiens_hsa006201.08460045
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08350324
47Alzheimers disease_Homo sapiens_hsa050101.08223966
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06229253
49Oocyte meiosis_Homo sapiens_hsa041141.05933951
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05207869
51Insulin secretion_Homo sapiens_hsa049111.05123262
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02761515
53Histidine metabolism_Homo sapiens_hsa003401.02629616
54Cardiac muscle contraction_Homo sapiens_hsa042601.01691071
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00452563
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.99385831
57Chemical carcinogenesis_Homo sapiens_hsa052040.97553242
58Vitamin B6 metabolism_Homo sapiens_hsa007500.97106046
59Parkinsons disease_Homo sapiens_hsa050120.94753378
60Peroxisome_Homo sapiens_hsa041460.94632856
61Cholinergic synapse_Homo sapiens_hsa047250.94164116
62Bile secretion_Homo sapiens_hsa049760.93974430
63Vibrio cholerae infection_Homo sapiens_hsa051100.93564843
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91423494
65Glucagon signaling pathway_Homo sapiens_hsa049220.91348527
66Oxytocin signaling pathway_Homo sapiens_hsa049210.89140563
67Cocaine addiction_Homo sapiens_hsa050300.87521589
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87048416
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86845087
70Calcium signaling pathway_Homo sapiens_hsa040200.85005053
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84952544
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83725631
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82007674
74Fatty acid biosynthesis_Homo sapiens_hsa000610.80736576
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80129295
76Estrogen signaling pathway_Homo sapiens_hsa049150.78457041
77Fatty acid degradation_Homo sapiens_hsa000710.75273512
78Thyroid hormone synthesis_Homo sapiens_hsa049180.74113176
79Tight junction_Homo sapiens_hsa045300.73657676
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72959176
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70369498
82Carbon metabolism_Homo sapiens_hsa012000.70180586
83Glioma_Homo sapiens_hsa052140.70125640
84cAMP signaling pathway_Homo sapiens_hsa040240.67874631
85Gap junction_Homo sapiens_hsa045400.67646854
86Retinol metabolism_Homo sapiens_hsa008300.66353754
87Wnt signaling pathway_Homo sapiens_hsa043100.65247195
88Hippo signaling pathway_Homo sapiens_hsa043900.64661898
89Tryptophan metabolism_Homo sapiens_hsa003800.63381372
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62737269
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61727332
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.60603616
93PPAR signaling pathway_Homo sapiens_hsa033200.59975478
94GnRH signaling pathway_Homo sapiens_hsa049120.59353740
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.59050254
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59015628
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58654960
98Arginine and proline metabolism_Homo sapiens_hsa003300.56526457
99Phototransduction_Homo sapiens_hsa047440.55595793
100ErbB signaling pathway_Homo sapiens_hsa040120.55321085
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54979343
102Pancreatic secretion_Homo sapiens_hsa049720.52860051
103AMPK signaling pathway_Homo sapiens_hsa041520.52803446
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.52689154
105Huntingtons disease_Homo sapiens_hsa050160.52622337
106beta-Alanine metabolism_Homo sapiens_hsa004100.51270958
107Tyrosine metabolism_Homo sapiens_hsa003500.50222652
108Rap1 signaling pathway_Homo sapiens_hsa040150.50207953
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48936593
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48917439
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48646601
112Complement and coagulation cascades_Homo sapiens_hsa046100.47745161
113Folate biosynthesis_Homo sapiens_hsa007900.47219987
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46695450
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.45016486
116Biosynthesis of amino acids_Homo sapiens_hsa012300.44461126
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44404916
118Glycerolipid metabolism_Homo sapiens_hsa005610.44068565
119Phenylalanine metabolism_Homo sapiens_hsa003600.42864890
120ABC transporters_Homo sapiens_hsa020100.41501748
121Ovarian steroidogenesis_Homo sapiens_hsa049130.41185444
122Dorso-ventral axis formation_Homo sapiens_hsa043200.40986069
123Insulin signaling pathway_Homo sapiens_hsa049100.40573729
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38706414
125Hedgehog signaling pathway_Homo sapiens_hsa043400.38628969
126Ras signaling pathway_Homo sapiens_hsa040140.37826984
127Inositol phosphate metabolism_Homo sapiens_hsa005620.36935591
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36300152

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