OSBPL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin cytoskeleton. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hypotonic response (GO:0006971)4.38299143
2nuclear pore complex assembly (GO:0051292)4.22973639
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.04789150
4membrane raft organization (GO:0031579)4.04359296
5positive regulation of cellular amide metabolic process (GO:0034250)3.78747574
6bundle of His cell to Purkinje myocyte communication (GO:0086069)3.72937516
7detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.64816259
8detection of temperature stimulus involved in sensory perception (GO:0050961)3.64816259
9nuclear pore organization (GO:0006999)3.63354323
10Golgi transport vesicle coating (GO:0048200)3.47598469
11COPI coating of Golgi vesicle (GO:0048205)3.47598469
12pore complex assembly (GO:0046931)3.35551237
13peripheral nervous system neuron development (GO:0048935)3.35312469
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.34651073
15positive regulation by organism of defense response of other organism involved in symbiotic interact3.34651073
16modulation by symbiont of host immune response (GO:0052553)3.34651073
17positive regulation by symbiont of host defense response (GO:0052509)3.34651073
18modulation by symbiont of host defense response (GO:0052031)3.34651073
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.34651073
20cellular response to nicotine (GO:0071316)3.34202766
21detection of temperature stimulus (GO:0016048)3.34002434
22positive regulation of macrophage differentiation (GO:0045651)3.33890632
23regulation of histone H3-K27 methylation (GO:0061085)3.25786571
24protein localization to endosome (GO:0036010)3.24880367
25skin morphogenesis (GO:0043589)3.20698536
26neurofilament cytoskeleton organization (GO:0060052)3.19505822
27negative regulation of dendrite morphogenesis (GO:0050774)3.19395628
28negative regulation of cell killing (GO:0031342)3.18915743
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.18915743
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.11464688
31neutrophil activation involved in immune response (GO:0002283)3.11018715
32phospholipid scrambling (GO:0017121)3.08568005
33leukocyte aggregation (GO:0070486)3.08349969
34positive regulation of heat generation (GO:0031652)3.02906974
35plasma membrane repair (GO:0001778)3.01965290
36regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.99309678
37behavioral response to pain (GO:0048266)2.99120370
38antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98567547
39NIK/NF-kappaB signaling (GO:0038061)2.97345108
40interferon-gamma production (GO:0032609)2.92087315
41regulation of necroptotic process (GO:0060544)2.90223394
42B cell receptor signaling pathway (GO:0050853)2.88930959
43positive regulation of gamma-delta T cell activation (GO:0046645)2.88187534
44cell adhesion mediated by integrin (GO:0033627)2.87873838
45cell-substrate junction assembly (GO:0007044)2.81387596
46leukocyte cell-cell adhesion (GO:0007159)2.79915548
47mammary gland epithelial cell proliferation (GO:0033598)2.78229039
48positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.77802079
49regulation of fever generation (GO:0031620)2.74684298
50response to host immune response (GO:0052572)2.72942797
51response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.72942797
52hepatocyte apoptotic process (GO:0097284)2.71949798
53neuronal action potential (GO:0019228)2.69711686
54regulation of fibroblast apoptotic process (GO:2000269)2.69345665
55mitotic chromosome condensation (GO:0007076)2.69115375
56germinal center formation (GO:0002467)2.68238853
57pinocytosis (GO:0006907)2.67521883
58antigen processing and presentation of endogenous antigen (GO:0019883)2.65866823
59regulation of chronic inflammatory response (GO:0002676)2.63106609
60response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.60186571
61response to host (GO:0075136)2.60186571
62response to host defenses (GO:0052200)2.60186571
63macrophage activation involved in immune response (GO:0002281)2.59924187
64substrate-dependent cell migration (GO:0006929)2.59730690
65regulation of podosome assembly (GO:0071801)2.58423898
66granulocyte activation (GO:0036230)2.58207873
67cell communication involved in cardiac conduction (GO:0086065)2.57880427
68negative regulation of osteoblast proliferation (GO:0033689)2.55097967
69regulation of RNA export from nucleus (GO:0046831)2.55061526
70negative regulation of T cell mediated immunity (GO:0002710)2.54282572
71response to pain (GO:0048265)2.52806588
72mesodermal cell differentiation (GO:0048333)2.52268890
73regulation of histone phosphorylation (GO:0033127)2.51537900
74positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.49833610
75negative regulation of necroptotic process (GO:0060546)2.49827163
76thrombin receptor signaling pathway (GO:0070493)2.49194443
77myeloid cell activation involved in immune response (GO:0002275)2.48989634
78positive regulation of chemokine biosynthetic process (GO:0045080)2.48970650
79positive regulation of muscle hypertrophy (GO:0014742)2.47785747
80positive regulation of cardiac muscle hypertrophy (GO:0010613)2.47785747
81regulation of cardiac muscle cell contraction (GO:0086004)2.47637733
82regulation of relaxation of muscle (GO:1901077)2.46075053
83cilium or flagellum-dependent cell motility (GO:0001539)2.43114660
84regulation of nucleobase-containing compound transport (GO:0032239)2.43106552
85superoxide anion generation (GO:0042554)2.42750595
86embryonic process involved in female pregnancy (GO:0060136)2.42390693
87response to interleukin-15 (GO:0070672)2.42165351
88necroptotic process (GO:0070266)2.41265553
89regulation of cell communication by electrical coupling (GO:0010649)2.40353284
90negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.39726778
91negative regulation of T-helper cell differentiation (GO:0045623)2.39726778
92mitotic sister chromatid cohesion (GO:0007064)2.38892939
93negative T cell selection (GO:0043383)2.38665049
94regulation of type I interferon-mediated signaling pathway (GO:0060338)2.38331862
95regulation of B cell receptor signaling pathway (GO:0050855)2.38055802
96glomerular epithelial cell development (GO:0072310)2.37984350
97membrane protein ectodomain proteolysis (GO:0006509)2.37296882
98positive regulation of B cell differentiation (GO:0045579)2.37209147
99heterotypic cell-cell adhesion (GO:0034113)2.36931747
100negative regulation of homotypic cell-cell adhesion (GO:0034111)2.36818868
101neutrophil activation (GO:0042119)2.36559973
102negative thymic T cell selection (GO:0045060)2.36373757
103CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.36031695
104T cell migration (GO:0072678)2.35962791
105regulation of RIG-I signaling pathway (GO:0039535)2.34857544
106hepatocyte differentiation (GO:0070365)2.34809302
107chaperone mediated protein folding requiring cofactor (GO:0051085)2.34694744
108thymic T cell selection (GO:0045061)2.34116408
109regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.33651173
110regulation of isotype switching to IgG isotypes (GO:0048302)2.33587842
111hydrogen peroxide biosynthetic process (GO:0050665)2.32688049
112response to peptidoglycan (GO:0032494)2.31264282
113T cell lineage commitment (GO:0002360)2.31190304
114pericardium development (GO:0060039)2.31173761
115positive regulation of interleukin-1 production (GO:0032732)2.30757320
116negative regulation of fibroblast apoptotic process (GO:2000270)2.30055904
117cellular response to interleukin-15 (GO:0071350)2.29006185
118proline transport (GO:0015824)2.28387361
119activation of Rac GTPase activity (GO:0032863)2.28209807
120negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.28048566
121DNA unwinding involved in DNA replication (GO:0006268)2.27685924
122positive regulation of extracellular matrix organization (GO:1903055)2.26974748
123interferon-gamma-mediated signaling pathway (GO:0060333)2.25750233
124lipopolysaccharide-mediated signaling pathway (GO:0031663)2.25316700
125hemidesmosome assembly (GO:0031581)2.25189758
126cellular response to ethanol (GO:0071361)2.24734523
127negative regulation of anoikis (GO:2000811)2.24575904
128desmosome organization (GO:0002934)2.23831054
129mature B cell differentiation involved in immune response (GO:0002313)2.23288987
130positive regulation of alpha-beta T cell proliferation (GO:0046641)2.22556835
131response to water (GO:0009415)2.22214968
132negative regulation of DNA repair (GO:0045738)2.20808341
133regulation of mitotic spindle organization (GO:0060236)2.20590872
134COPII vesicle coating (GO:0048208)2.20459052
135regulation of platelet aggregation (GO:0090330)2.20204772
136positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.19896656
137regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.19634738
138positive regulation of calcium-mediated signaling (GO:0050850)2.19566884
139positive regulation of granulocyte differentiation (GO:0030854)2.18330201
140tolerance induction (GO:0002507)2.18176630
141barbed-end actin filament capping (GO:0051016)2.18018167
142mature B cell differentiation (GO:0002335)2.17718274
143negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.16274038
144positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.15767602
145positive regulation of lamellipodium assembly (GO:0010592)2.15461851
146regulation of anoikis (GO:2000209)2.15321380
147phagosome maturation (GO:0090382)2.14442785
148positive T cell selection (GO:0043368)2.14192274
149cell-substrate adherens junction assembly (GO:0007045)2.13552361
150focal adhesion assembly (GO:0048041)2.13552361
151iron ion import (GO:0097286)2.13146380
152regulation of translational termination (GO:0006449)2.13061436
153lymphocyte migration (GO:0072676)2.11976318
154regulation of homotypic cell-cell adhesion (GO:0034110)2.11924597
155positive thymic T cell selection (GO:0045059)2.11204677
156response to protozoan (GO:0001562)2.10133618
157axonemal dynein complex assembly (GO:0070286)2.09893017
158positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.09822096
159regulation of actin filament-based movement (GO:1903115)2.09273357
160negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.09270028
161regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.09216784
162regulation of cellular amide metabolic process (GO:0034248)2.08971999
163respiratory burst (GO:0045730)2.08836624
164negative regulation of thymocyte apoptotic process (GO:0070244)2.08574348
165regulation of chemokine biosynthetic process (GO:0045073)2.08443120
166B cell proliferation (GO:0042100)2.08260437
167interleukin-1-mediated signaling pathway (GO:0070498)2.07984891
168regulation of natural killer cell mediated immunity (GO:0002715)2.07932632
169regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.07932632
170response to type I interferon (GO:0034340)2.07609845
171cellular response to interferon-alpha (GO:0035457)2.07258426
172positive regulation of isotype switching (GO:0045830)2.07211950
173negative regulation of calcium ion transport into cytosol (GO:0010523)2.07029917
174apoptotic cell clearance (GO:0043277)2.06973275
175membrane depolarization during action potential (GO:0086010)2.06841411
176positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.04708270
177T cell selection (GO:0045058)2.04219803
178cytoskeleton-dependent cytokinesis (GO:0061640)2.04186641
179regulation of transforming growth factor beta1 production (GO:0032908)2.03614384
180positive regulation of protein import into nucleus, translocation (GO:0033160)2.03178878
181regulation of protein polyubiquitination (GO:1902914)2.02852877
182positive regulation of blood vessel endothelial cell migration (GO:0043536)2.02130157
183programmed necrotic cell death (GO:0097300)1.99632543
184lymph node development (GO:0048535)1.99021174
185B cell homeostasis (GO:0001782)1.98214780
186glucocorticoid receptor signaling pathway (GO:0042921)1.98168988
187nuclear envelope disassembly (GO:0051081)1.98077089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.27497208
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88587990
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.46514359
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.44957777
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.28406167
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.85184141
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.77161378
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.67770499
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.65957812
10MYC_22102868_ChIP-Seq_BL_Human2.44198025
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.35824939
12* IRF8_21731497_ChIP-ChIP_J774_Mouse2.32364614
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.14366034
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05170972
15KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.96674066
16* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95659444
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94736638
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.93434064
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81189801
20* RUNX_20019798_ChIP-Seq_JUKART_Human1.79730349
21STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76770988
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73077963
23* IRF8_27001747_Chip-Seq_BMDM_Mouse1.72705473
24MYB_26560356_Chip-Seq_TH1_Human1.71057594
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.69678963
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68606068
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.68037685
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67798095
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65730596
30BRD4_25478319_ChIP-Seq_HGPS_Human1.64209681
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62879211
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60338225
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.59152460
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.58621974
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.57034694
36AR_21909140_ChIP-Seq_LNCAP_Human1.55916081
37FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.55869968
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55531211
39* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.55502381
40AHR_22903824_ChIP-Seq_MCF-7_Human1.55324064
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55259671
42* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.54659322
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53903801
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53657170
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.50778964
46GBX2_23144817_ChIP-Seq_PC3_Human1.47224791
47* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46504007
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45964411
49* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44848304
50SOX2_20726797_ChIP-Seq_SW620_Human1.42635467
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42045367
52* RUNX1_22412390_ChIP-Seq_EML_Mouse1.41543437
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.41515097
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.41320330
55* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41196016
56CJUN_26792858_Chip-Seq_BT549_Human1.40339801
57RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39818439
58VDR_24787735_ChIP-Seq_THP-1_Human1.38260597
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.37412230
60SPI1_23547873_ChIP-Seq_NB4_Human1.36176483
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34092016
62ZNF263_19887448_ChIP-Seq_K562_Human1.33907816
63TCF4_18268006_ChIP-ChIP_LS174T_Human1.32934716
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32908531
65ATF3_27146783_Chip-Seq_COLON_Human1.31677639
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30911067
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30911067
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30657139
69TCF7_22412390_ChIP-Seq_EML_Mouse1.30459935
70CLOCK_20551151_ChIP-Seq_293T_Human1.26604220
71TFEB_21752829_ChIP-Seq_HELA_Human1.26399876
72E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25912282
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.25554629
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24847180
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24811202
76UBF1/2_26484160_Chip-Seq_HMECs_Human1.24297621
77* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23946740
78EZH2_22144423_ChIP-Seq_EOC_Human1.23700110
79* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23676608
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23094110
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.21193109
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20924467
83* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20802579
84SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20738364
85* SPI1_23127762_ChIP-Seq_K562_Human1.19033931
86* TP53_18474530_ChIP-ChIP_U2OS_Human1.18670884
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18031318
88VDR_21846776_ChIP-Seq_THP-1_Human1.16939349
89PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16878158
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16553894
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.16532416
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16347066
93TAF15_26573619_Chip-Seq_HEK293_Human1.16115202
94* SMAD4_21799915_ChIP-Seq_A2780_Human1.15941854
95MYB_26560356_Chip-Seq_TH2_Human1.15854960
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15310820
97* UTX_26944678_Chip-Seq_JUKART_Human1.13769284
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13378831
99* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11823114
100* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11823114
101MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11256773
102* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10944581
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10492987
104IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10487549
105GATA1_22025678_ChIP-Seq_K562_Human1.10137894
106ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10106813
107VDR_24763502_ChIP-Seq_THP-1_Human1.10090432
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08271983
109RXR_22108803_ChIP-Seq_LS180_Human1.08243092
110EGR1_19032775_ChIP-ChIP_M12_Human1.08189274
111E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07873074
112ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07222562
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07081776
114JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07028596
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06684457
116RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06147473
117EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06147473
118GATA3_27048872_Chip-Seq_THYMUS_Human1.05900545
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05379416
120SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05054834
121TRIM28_21343339_ChIP-Seq_HEK293_Human1.04807130
122PIAS1_25552417_ChIP-Seq_VCAP_Human1.04436989
123STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01824572
124* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01566628
125JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00941712
126* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00104898
127CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99947482
128STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99443161
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.98422909
130* TP53_22127205_ChIP-Seq_IMR90_Human0.98343461
131* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97508413
132LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97489307
133SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97354011
134MAF_26560356_Chip-Seq_TH2_Human0.97348340
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97314691
136P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96819110
137NCOR1_26117541_ChIP-Seq_K562_Human0.96349542
138KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95855018
139RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95789775
140EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95715662
141JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95309270
142TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94978965
143DROSHA_22980978_ChIP-Seq_HELA_Human0.94465906
144SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93763517
145E2F1_21310950_ChIP-Seq_MCF-7_Human0.92757900
146* TP63_23658742_ChIP-Seq_EP156T_Human0.92711472
147TP53_16413492_ChIP-PET_HCT116_Human0.92131794
148WT1_19549856_ChIP-ChIP_CCG9911_Human0.91655852
149TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90747353
150MAF_26560356_Chip-Seq_TH1_Human0.88714120
151CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88011119
152SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87700621
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86895710
154KLF5_25053715_ChIP-Seq_YYC3_Human0.86428559
155SMAD3_21741376_ChIP-Seq_HESCs_Human0.86311361
156* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86260991
157AR_25329375_ChIP-Seq_VCAP_Human0.85885266
158PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85632342
159KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85519647
160PU_27001747_Chip-Seq_BMDM_Mouse0.85346077
161* PRDM14_20953172_ChIP-Seq_ESCs_Human0.84147811
162* GATA2_19941826_ChIP-Seq_K562_Human0.84139478

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception4.90753716
2MP0001968_abnormal_touch/_nociception3.62312847
3MP0002736_abnormal_nociception_after3.39214165
4MP0002877_abnormal_melanocyte_morpholog3.09453573
5MP0004510_myositis2.90327152
6MP0004858_abnormal_nervous_system2.83211337
7MP0009785_altered_susceptibility_to2.78234723
8MP0001986_abnormal_taste_sensitivity2.69320927
9MP0008438_abnormal_cutaneous_collagen2.63451343
10MP0003300_gastrointestinal_ulcer2.52973234
11MP0003705_abnormal_hypodermis_morpholog2.47720282
12MP0002733_abnormal_thermal_nociception2.36662834
13MP0003950_abnormal_plasma_membrane2.33494627
14MP0005671_abnormal_response_to2.31583650
15MP0002138_abnormal_hepatobiliary_system2.13395061
16MP0000569_abnormal_digit_pigmentation2.12654860
17MP0003724_increased_susceptibility_to2.10664311
18MP0001835_abnormal_antigen_presentation2.09383133
19MP0003045_fibrosis2.04178793
20MP0003303_peritoneal_inflammation2.02585518
21MP0001970_abnormal_pain_threshold1.99743007
22MP0005000_abnormal_immune_tolerance1.98610678
23MP0003436_decreased_susceptibility_to1.95758239
24MP0006082_CNS_inflammation1.94545617
25MP0004947_skin_inflammation1.92616488
26MP0008057_abnormal_DNA_replication1.87952892
27MP0002148_abnormal_hypersensitivity_rea1.86563461
28MP0003183_abnormal_peptide_metabolism1.85009192
29MP0004270_analgesia1.84329889
30MP0005451_abnormal_body_composition1.78067645
31MP0005023_abnormal_wound_healing1.77908007
32MP0002419_abnormal_innate_immunity1.73903687
33MP0002060_abnormal_skin_morphology1.73249535
34MP0005025_abnormal_response_to1.72334136
35MP0005058_abnormal_lysosome_morphology1.70254929
36MP0002396_abnormal_hematopoietic_system1.70189969
37MP0002734_abnormal_mechanical_nocicepti1.67799063
38MP0004272_abnormal_basement_membrane1.63669297
39MP0003191_abnormal_cellular_cholesterol1.60367823
40MP0001853_heart_inflammation1.59812782
41MP0003453_abnormal_keratinocyte_physiol1.59118163
42MP0005076_abnormal_cell_differentiation1.54806678
43MP0004808_abnormal_hematopoietic_stem1.54775329
44MP0005275_abnormal_skin_tensile1.52932519
45MP0003566_abnormal_cell_adhesion1.52342052
46MP0000858_altered_metastatic_potential1.50684766
47MP0001958_emphysema1.47808656
48MP0008260_abnormal_autophagy1.45632190
49MP0005464_abnormal_platelet_physiology1.45443476
50MP0006054_spinal_hemorrhage1.43446264
51MP0001819_abnormal_immune_cell1.40317282
52MP0002723_abnormal_immune_serum1.39464448
53MP0001765_abnormal_ion_homeostasis1.39459887
54MP0005387_immune_system_phenotype1.39168960
55MP0001790_abnormal_immune_system1.39168960
56MP0002452_abnormal_antigen_presenting1.38670932
57MP0002420_abnormal_adaptive_immunity1.38489757
58MP0001873_stomach_inflammation1.38240693
59MP0002006_tumorigenesis1.37935685
60MP0004084_abnormal_cardiac_muscle1.37291240
61MP0005165_increased_susceptibility_to1.36349492
62MP0010155_abnormal_intestine_physiology1.35065318
63MP0006276_abnormal_autonomic_nervous1.34042669
64MP0000372_irregular_coat_pigmentation1.33973644
65MP0002998_abnormal_bone_remodeling1.30685726
66MP0010678_abnormal_skin_adnexa1.29193389
67MP0010234_abnormal_vibrissa_follicle1.29009109
68MP0004484_altered_response_of1.28443954
69MP0001845_abnormal_inflammatory_respons1.28222602
70MP0001800_abnormal_humoral_immune1.27289846
71MP0010368_abnormal_lymphatic_system1.27138068
72MP0001216_abnormal_epidermal_layer1.26861554
73MP0003279_aneurysm1.25992054
74MP0010094_abnormal_chromosome_stability1.25198755
75MP0003172_abnormal_lysosome_physiology1.23124728
76MP0003448_altered_tumor_morphology1.22776504
77MP0005623_abnormal_meninges_morphology1.22695160
78MP0002009_preneoplasia1.20451424
79MP0009764_decreased_sensitivity_to1.17708901
80MP0010352_gastrointestinal_tract_polyps1.16340278
81MP0000703_abnormal_thymus_morphology1.14475182
82MP0003646_muscle_fatigue1.14429027
83MP0005621_abnormal_cell_physiology1.14133690
84MP0003763_abnormal_thymus_physiology1.12195729
85MP0002796_impaired_skin_barrier1.12023060
86MP0005174_abnormal_tail_pigmentation1.11473386
87MP0005166_decreased_susceptibility_to1.10551351
88MP0008007_abnormal_cellular_replicative1.09919151
89MP0003111_abnormal_nucleus_morphology1.09425242
90MP0004957_abnormal_blastocyst_morpholog1.09122722
91MP0000015_abnormal_ear_pigmentation1.09010858
92MP0001533_abnormal_skeleton_physiology1.08973832
93MP0003656_abnormal_erythrocyte_physiolo1.08707449
94MP0003091_abnormal_cell_migration1.08700473
95MP0000538_abnormal_urinary_bladder1.06378183
96MP0003866_abnormal_defecation1.05868053
97MP0002166_altered_tumor_susceptibility1.05865349
98MP0002722_abnormal_immune_system1.05531893
99MP0004859_abnormal_synaptic_plasticity1.04752555
100MP0002972_abnormal_cardiac_muscle1.04750907
101MP0005501_abnormal_skin_physiology1.04265493
102MP0000733_abnormal_muscle_development1.04122253
103MP0001243_abnormal_dermal_layer1.03400150
104MP0002429_abnormal_blood_cell1.03045584
105MP0002405_respiratory_system_inflammati1.02948814
106MP0005164_abnormal_response_to1.01071721
107MP0003077_abnormal_cell_cycle0.99495876
108MP0008004_abnormal_stomach_pH0.99382075
109MP0001915_intracranial_hemorrhage0.99208798
110MP0000689_abnormal_spleen_morphology0.97132560
111MP0008775_abnormal_heart_ventricle0.96810547
112MP0002136_abnormal_kidney_physiology0.96518860
113MP0000343_altered_response_to0.94848244
114MP0001849_ear_inflammation0.94266113
115MP0002019_abnormal_tumor_incidence0.93970799
116MP0000350_abnormal_cell_proliferation0.93475725
117MP0005257_abnormal_intraocular_pressure0.93287812
118MP0000685_abnormal_immune_system0.93171276
119MP0000465_gastrointestinal_hemorrhage0.91936400
120MP0009333_abnormal_splenocyte_physiolog0.90931836
121MP0004185_abnormal_adipocyte_glucose0.90826487
122MP0009046_muscle_twitch0.90321244
123MP0002928_abnormal_bile_duct0.89865230
124MP0003828_pulmonary_edema0.89630252
125MP0001663_abnormal_digestive_system0.88480100
126MP0010307_abnormal_tumor_latency0.88385861
127MP0008874_decreased_physiological_sensi0.88351916
128MP0005083_abnormal_biliary_tract0.86379486
129MP0001348_abnormal_lacrimal_gland0.85939914
130MP0002168_other_aberrant_phenotype0.85727385
131MP0002896_abnormal_bone_mineralization0.85589002
132MP0008469_abnormal_protein_level0.85381900
133MP0005310_abnormal_salivary_gland0.85071479
134MP0001191_abnormal_skin_condition0.84930964
135MP0001851_eye_inflammation0.84106677
136MP0001188_hyperpigmentation0.83892967
137MP0002067_abnormal_sensory_capabilities0.83309587
138MP0002933_joint_inflammation0.82977243
139MP0000383_abnormal_hair_follicle0.82868384
140MP0000767_abnormal_smooth_muscle0.81784511
141MP0003075_altered_response_to0.81762558
142MP0001501_abnormal_sleep_pattern0.81500468
143MP0000716_abnormal_immune_system0.81442506
144MP0001730_embryonic_growth_arrest0.79847367
145MP0000604_amyloidosis0.79063108
146MP0002398_abnormal_bone_marrow0.78296506
147MP0009278_abnormal_bone_marrow0.78103858
148MP0010386_abnormal_urinary_bladder0.77602720
149MP0001270_distended_abdomen0.76933441
150MP0002751_abnormal_autonomic_nervous0.76395981
151MP0009643_abnormal_urine_homeostasis0.75171406
152MP0000749_muscle_degeneration0.74498291
153MP0000751_myopathy0.73668145

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)4.51855140
2Optic neuritis (HP:0100653)4.51855140
3Orchitis (HP:0100796)4.18724553
4Eczematoid dermatitis (HP:0000976)4.06702489
5Myositis (HP:0100614)4.00294493
6Ulnar claw (HP:0001178)3.84566990
7Recurrent abscess formation (HP:0002722)3.50326336
8Premature rupture of membranes (HP:0001788)3.45086221
9Stomatitis (HP:0010280)3.33760034
10Autoimmune thrombocytopenia (HP:0001973)3.26467366
11Osteolytic defects of the hand bones (HP:0009699)3.24308410
12Osteolytic defects of the phalanges of the hand (HP:0009771)3.24308410
13Abnormality of oral frenula (HP:0000190)3.21519761
14Protrusio acetabuli (HP:0003179)3.21110160
15Abnormality of macrophages (HP:0004311)3.12595051
16Hypothermia (HP:0002045)3.11588711
17Axonal loss (HP:0003447)3.10277449
18Vascular tortuosity (HP:0004948)3.07522203
19T lymphocytopenia (HP:0005403)3.04846597
20Arterial tortuosity (HP:0005116)3.03863474
21Ankyloglossia (HP:0010296)3.03134408
22Febrile seizures (HP:0002373)3.02186519
23Interstitial pulmonary disease (HP:0006530)3.00088030
24Spondylolisthesis (HP:0003302)2.98428440
25Glucose intolerance (HP:0000833)2.90593875
26Abnormality of T cell number (HP:0011839)2.84051045
27Recurrent viral infections (HP:0004429)2.83636633
28Focal motor seizures (HP:0011153)2.83423987
29Distal lower limb muscle weakness (HP:0009053)2.81533067
30Elevated erythrocyte sedimentation rate (HP:0003565)2.79630466
31Recurrent bronchitis (HP:0002837)2.77051064
32Arterial thrombosis (HP:0004420)2.74368123
33Hypomagnesemia (HP:0002917)2.73840548
34Milia (HP:0001056)2.65610680
35Abnormality of magnesium homeostasis (HP:0004921)2.64623376
36Segmental peripheral demyelination/remyelination (HP:0003481)2.64253267
37Recurrent bacterial skin infections (HP:0005406)2.63380013
38Vasculitis (HP:0002633)2.62507056
39Agammaglobulinemia (HP:0004432)2.58303053
40Mediastinal lymphadenopathy (HP:0100721)2.57740173
41Aortic dissection (HP:0002647)2.57710305
42Hypercortisolism (HP:0001578)2.55160507
43Aortic aneurysm (HP:0004942)2.55157627
44Entropion (HP:0000621)2.51717941
45Autoimmune hemolytic anemia (HP:0001890)2.50498224
46Flat acetabular roof (HP:0003180)2.50493043
47Abnormality of the nasal mucosa (HP:0000433)2.48625687
48Vertebral compression fractures (HP:0002953)2.44429126
49Gingivitis (HP:0000230)2.43449346
50Vacuolated lymphocytes (HP:0001922)2.43301773
51Keratoconjunctivitis sicca (HP:0001097)2.39992028
52Syringomyelia (HP:0003396)2.36437524
53Spinal cord lesions (HP:0100561)2.36437524
54Cervical subluxation (HP:0003308)2.36181832
55Hyperactive renin-angiotensin system (HP:0000841)2.35299756
56Absent frontal sinuses (HP:0002688)2.34772549
57Dilatation of the ascending aorta (HP:0005111)2.34477590
58Right ventricular cardiomyopathy (HP:0011663)2.34015881
59Pulmonary infiltrates (HP:0002113)2.33842648
60Short nail (HP:0001799)2.32930333
61Atonic seizures (HP:0010819)2.28265489
62Impaired pain sensation (HP:0007328)2.27971971
63Abnormality of pain sensation (HP:0010832)2.27971971
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.25848817
65Cellulitis (HP:0100658)2.24893426
66Onycholysis (HP:0001806)2.23032070
67Fragile skin (HP:0001030)2.22627059
68Recurrent fungal infections (HP:0002841)2.21499425
69Bronchitis (HP:0012387)2.18359982
70Submucous cleft hard palate (HP:0000176)2.16997011
71Wormian bones (HP:0002645)2.16890246
72Keratoconjunctivitis (HP:0001096)2.15821378
73Obstructive lung disease (HP:0006536)2.14918980
74Chronic obstructive pulmonary disease (HP:0006510)2.14918980
75Action tremor (HP:0002345)2.12950262
76Distal upper limb amyotrophy (HP:0007149)2.12822592
77Upper limb amyotrophy (HP:0009129)2.12822592
78Chronic diarrhea (HP:0002028)2.12813044
79Prostate neoplasm (HP:0100787)2.11447983
80Subacute progressive viral hepatitis (HP:0006572)2.10774912
81Petechiae (HP:0000967)2.09793989
82Hemoptysis (HP:0002105)2.09335305
83Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.08894554
84Abnormality of the distal phalanges of the toes (HP:0010182)2.08285458
85Ureteral stenosis (HP:0000071)2.01484655
86Selective tooth agenesis (HP:0001592)2.01301417
87Recurrent otitis media (HP:0000403)2.00445018
88Episodic fever (HP:0001954)2.00184333
89Bronchiectasis (HP:0002110)1.99286593
90Abnormal glucose tolerance (HP:0001952)1.98649173
91Thick nail (HP:0001805)1.98643843
92Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.97118214
93Natal tooth (HP:0000695)1.96595633
94Paresthesia (HP:0003401)1.96561201
95Bradycardia (HP:0001662)1.96317314
96Elbow flexion contracture (HP:0002987)1.95923254
97Pustule (HP:0200039)1.95249833
98Abnormal delayed hypersensitivity skin test (HP:0002963)1.93965502
99Focal seizures (HP:0007359)1.93437685
100Adrenal overactivity (HP:0002717)1.93252099
101Abnormality of the acetabulum (HP:0003170)1.92858290
102Hyperacusis (HP:0010780)1.91435167
103Poikiloderma (HP:0001029)1.91413002
104Abnormality of T cells (HP:0002843)1.90834855
105Myokymia (HP:0002411)1.90729241
106Hand muscle atrophy (HP:0009130)1.90640104
107Viral hepatitis (HP:0006562)1.90579323
108Autoamputation (HP:0001218)1.90304186
109Ureteral obstruction (HP:0006000)1.90279595
110Premature loss of primary teeth (HP:0006323)1.89789633
111Atrophic scars (HP:0001075)1.89204446
112Abnormality of chloride homeostasis (HP:0011422)1.88966659
113Delayed closure of the anterior fontanelle (HP:0001476)1.88786648
114Thoracolumbar scoliosis (HP:0002944)1.88480038
115Increased cerebral lipofuscin (HP:0011813)1.87638564
116Recurrent sinusitis (HP:0011108)1.87350292
117Foot dorsiflexor weakness (HP:0009027)1.86370802
118IgA deficiency (HP:0002720)1.85637521
119Bladder diverticulum (HP:0000015)1.84889004
120Ankle contracture (HP:0006466)1.84523914
121Abnormal platelet function (HP:0011869)1.83232393
122Impaired platelet aggregation (HP:0003540)1.83232393
123Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.82595977
124Anorexia (HP:0002039)1.82565037
125Menorrhagia (HP:0000132)1.82492458
126Follicular hyperkeratosis (HP:0007502)1.82259026
127Sudden death (HP:0001699)1.82028522
128Joint swelling (HP:0001386)1.81153806
129Reduced subcutaneous adipose tissue (HP:0003758)1.80614512
130Alopecia of scalp (HP:0002293)1.80524154
131Increased IgE level (HP:0003212)1.80485059
132Encephalitis (HP:0002383)1.79952753
133Pheochromocytoma (HP:0002666)1.79180307
134Tetany (HP:0001281)1.78644507
135Abnormality of the prostate (HP:0008775)1.78194613
136Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.78142136
137Hyporeflexia of lower limbs (HP:0002600)1.78131721
138Potter facies (HP:0002009)1.78064701
139Facial shape deformation (HP:0011334)1.78064701
140Xerostomia (HP:0000217)1.77704541
141Nasal polyposis (HP:0100582)1.77556590
142Alveolar cell carcinoma (HP:0006519)1.76621606
143Prolonged bleeding time (HP:0003010)1.76577446
144Keratitis (HP:0000491)1.76232487
145Abnormality of proline metabolism (HP:0010907)1.76139370
146Hydroxyprolinuria (HP:0003080)1.76139370
147Nail dystrophy (HP:0008404)1.76104188
148Meningitis (HP:0001287)1.75854454
149Hypoplasia of the thymus (HP:0000778)1.75256506
150Fatigue (HP:0012378)1.75215802
151Sparse lateral eyebrow (HP:0005338)1.74883030
152Distal lower limb amyotrophy (HP:0008944)1.74824150
153Coarse hair (HP:0002208)1.74573367
154Panhypogammaglobulinemia (HP:0003139)1.74208199
155Persistence of primary teeth (HP:0006335)1.73646652
156Increased circulating renin level (HP:0000848)1.73066279
157Osteomyelitis (HP:0002754)1.72197575
158Metabolic alkalosis (HP:0200114)1.71640959
159Syncope (HP:0001279)1.71184206
160Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.70843581
161Curly hair (HP:0002212)1.70517654
162Abnormality of the vocal cords (HP:0008777)1.70465288
163Periodontitis (HP:0000704)1.70081002
164Chronic sinusitis (HP:0011109)1.69750249
165Increased neuronal autofluorescent lipopigment (HP:0002074)1.69461999
166Ridged nail (HP:0001807)1.68946037
167Abnormality of the pericardium (HP:0001697)1.68788652
168Bilateral sensorineural hearing impairment (HP:0008619)1.68528010
169Abnormal platelet volume (HP:0011876)1.67745571
170Distal arthrogryposis (HP:0005684)1.66869805
171Micronodular cirrhosis (HP:0001413)1.66852844
172Broad face (HP:0000283)1.66687284
173Thoracic kyphosis (HP:0002942)1.66447207
174Gastrointestinal infarctions (HP:0005244)1.66227556
175Spinal rigidity (HP:0003306)1.66068662
176Verrucae (HP:0200043)1.66064049
177Papilloma (HP:0012740)1.66064049
178Mitral regurgitation (HP:0001653)1.66023762
179Rhinitis (HP:0012384)1.65893785
180B lymphocytopenia (HP:0010976)1.64838935
181Insomnia (HP:0100785)1.64089719
182Increased connective tissue (HP:0009025)1.63878176
183Gastrointestinal stroma tumor (HP:0100723)1.63276777
184Abnormality of carpal bone ossification (HP:0006257)1.62490991
185Heterotopia (HP:0002282)1.61770696
186Colitis (HP:0002583)1.61592526
187Vertebral arch anomaly (HP:0008438)1.60140910
188Absent/shortened dynein arms (HP:0200106)1.59858367
189Dynein arm defect of respiratory motile cilia (HP:0012255)1.59858367
190Combined immunodeficiency (HP:0005387)1.59684568
191Abnormal respiratory motile cilium physiology (HP:0012261)1.59580589
192Aneurysm (HP:0002617)1.58760743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.13071149
2TXK3.55414942
3CDK122.72507731
4MST1R2.63600436
5MAP3K122.52215651
6MAP3K22.48706335
7NTRK12.40333054
8MATK2.35410913
9LMTK22.31918568
10CASK2.26308198
11SCYL22.25883892
12MAP3K142.17789291
13MST42.13881331
14JAK12.13111702
15JAK32.05431488
16ERN11.98945484
17SMG11.96714751
18MET1.96653120
19KSR21.92154919
20TTN1.87744176
21ICK1.81456155
22PDGFRA1.73338330
23TBK11.71214097
24PRPF4B1.70295152
25IRAK31.68446938
26EIF2AK31.59714311
27FER1.57903126
28PIK3CA1.56394403
29TGFBR21.51802599
30DAPK21.49234919
31ERBB41.48993993
32EPHA31.48648324
33TYK21.48490758
34TRPM71.47696767
35FRK1.43296399
36EIF2AK11.42998756
37WNK41.40013505
38MAPKAPK31.37772522
39BMPR21.33957534
40EEF2K1.30996726
41MELK1.28457411
42NEK91.24131110
43RET1.23221685
44EPHA21.19568951
45MAPK111.17904696
46PBK1.17688520
47RPS6KA21.17587021
48MINK11.16594063
49LRRK21.16258829
50IKBKE1.15111027
51CDK61.12082450
52CDK81.11363958
53PAK41.11238207
54MOS1.10154232
55MAP2K11.09635713
56TESK11.07617353
57TESK21.05479246
58TRIB31.05351248
59MAP4K11.03600046
60LATS11.02892559
61MARK31.02834812
62FES1.02196906
63KIT1.02016702
64SGK31.00665341
65SGK21.00195706
66PDGFRB0.98612999
67MAP2K70.98175555
68PRKG20.97994860
69LCK0.97606556
70FGFR30.96686335
71NTRK30.96575495
72MAP3K80.95023620
73PIM20.95012344
74BLK0.94375747
75BRD40.94097134
76MYLK0.92458624
77PTK20.92422461
78ZAP700.91962084
79TTK0.91686784
80MAP3K10.89715554
81STK380.89317917
82ITK0.88739236
83CDK40.88693518
84PRKCE0.88178954
85MAP3K30.86326796
86YES10.84129774
87MAP3K100.83678750
88GRK50.83310361
89BTK0.82786626
90CSF1R0.82388540
91MAP3K90.82380413
92SIK30.78483173
93NME20.77392181
94MAP2K30.76265892
95EPHB10.75546703
96DAPK10.75532654
97MAP2K20.75502808
98CLK10.74354630
99SYK0.73240872
100FGFR40.72184198
101RIPK10.71903658
102HCK0.69435135
103BRSK20.67203257
104MTOR0.66017613
105TEC0.65015479
106PAK20.64613528
107PLK20.64079951
108CAMKK20.63913159
109JAK20.63796129
110PIK3CG0.62041182
111ADRBK10.60402142
112STK240.59894568
113SGK2230.59817671
114SGK4940.59817671
115CSK0.59440293
116STK100.57980895
117CDK90.57949331
118IKBKB0.57788310
119MAPKAPK20.57199533
120AKT30.57088200
121MAP3K130.56910649
122FLT30.56667544
123STK30.56039953
124CDC42BPA0.55469365
125IRAK10.54629444
126SIK10.53050896
127FYN0.52457539
128PDK10.52279063
129RPS6KA40.52072739
130BMX0.51113071
131PDPK10.50956915
132MAP3K70.50942936
133LATS20.50601968
134PRKCH0.50344129
135DAPK30.49282695
136RAF10.49032573
137BUB10.48902184
138MAP2K60.48859084
139WNK10.48253474
140CHEK10.47973801
141MAPK70.47206785
142RPS6KB20.46744900
143CDK70.46358283
144IRAK40.45958959
145PTK2B0.45790748
146EIF2AK20.45433736
147MAP3K50.45101333
148SRC0.44940229
149PDK20.44630939
150PRKCD0.44208243
151KSR10.43953087
152ADRBK20.43078085
153NEK60.42616109
154IGF1R0.41867833
155TSSK60.41705102
156LIMK10.40585773
157ARAF0.40327774
158CAMK2D0.39820949
159CHUK0.38036294

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053322.70846254
2Allograft rejection_Homo sapiens_hsa053302.14017641
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.12287767
4Leishmaniasis_Homo sapiens_hsa051402.03845508
5Collecting duct acid secretion_Homo sapiens_hsa049661.84434827
6Small cell lung cancer_Homo sapiens_hsa052221.75586647
7Salmonella infection_Homo sapiens_hsa051321.73979405
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71507487
9Rheumatoid arthritis_Homo sapiens_hsa053231.68294957
10Asthma_Homo sapiens_hsa053101.63872102
11Hematopoietic cell lineage_Homo sapiens_hsa046401.63206264
12Synaptic vesicle cycle_Homo sapiens_hsa047211.61610286
13Non-small cell lung cancer_Homo sapiens_hsa052231.60460546
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57391077
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56266187
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51414034
17Osteoclast differentiation_Homo sapiens_hsa043801.50317856
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48797679
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43135727
20Tuberculosis_Homo sapiens_hsa051521.42817992
21Other glycan degradation_Homo sapiens_hsa005111.42088049
22p53 signaling pathway_Homo sapiens_hsa041151.40192022
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40026775
24Type I diabetes mellitus_Homo sapiens_hsa049401.39955614
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.39870221
26TNF signaling pathway_Homo sapiens_hsa046681.39668851
27Mineral absorption_Homo sapiens_hsa049781.39636110
28Bladder cancer_Homo sapiens_hsa052191.35076394
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32704475
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31555504
31Non-homologous end-joining_Homo sapiens_hsa034501.30251773
32Pertussis_Homo sapiens_hsa051331.28945590
33Measles_Homo sapiens_hsa051621.28908744
34Viral carcinogenesis_Homo sapiens_hsa052031.28672398
35Toxoplasmosis_Homo sapiens_hsa051451.27418997
36Phagosome_Homo sapiens_hsa041451.26264779
37Herpes simplex infection_Homo sapiens_hsa051681.24940377
38MicroRNAs in cancer_Homo sapiens_hsa052061.22130246
39Cell cycle_Homo sapiens_hsa041101.21262659
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.19672599
41T cell receptor signaling pathway_Homo sapiens_hsa046601.18203074
42HTLV-I infection_Homo sapiens_hsa051661.15451259
43Autoimmune thyroid disease_Homo sapiens_hsa053201.13379673
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.12577634
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12052078
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11754663
47Shigellosis_Homo sapiens_hsa051311.10401364
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.09746562
49Legionellosis_Homo sapiens_hsa051341.08800427
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.07593817
51Thyroid cancer_Homo sapiens_hsa052161.07088289
52Amoebiasis_Homo sapiens_hsa051461.06691704
53Viral myocarditis_Homo sapiens_hsa054161.06311885
54Malaria_Homo sapiens_hsa051441.04871234
55Renal cell carcinoma_Homo sapiens_hsa052111.03942146
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01275903
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.99694135
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98816169
59Influenza A_Homo sapiens_hsa051640.98735700
60Prostate cancer_Homo sapiens_hsa052150.98227351
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97999459
62African trypanosomiasis_Homo sapiens_hsa051430.94847955
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94524433
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94127947
65Apoptosis_Homo sapiens_hsa042100.94024262
66Chemokine signaling pathway_Homo sapiens_hsa040620.93417477
67Nucleotide excision repair_Homo sapiens_hsa034200.92700056
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92204082
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91185697
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89315264
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.87633601
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87550810
73Epstein-Barr virus infection_Homo sapiens_hsa051690.87366005
74Colorectal cancer_Homo sapiens_hsa052100.87123240
75Hepatitis C_Homo sapiens_hsa051600.86480270
76Dilated cardiomyopathy_Homo sapiens_hsa054140.85680766
77Olfactory transduction_Homo sapiens_hsa047400.83286809
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.82388229
79Vibrio cholerae infection_Homo sapiens_hsa051100.80823777
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.80177865
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80073503
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80016987
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79095207
84Prolactin signaling pathway_Homo sapiens_hsa049170.77573161
85DNA replication_Homo sapiens_hsa030300.77530717
86Endocytosis_Homo sapiens_hsa041440.77068864
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76858814
88Antigen processing and presentation_Homo sapiens_hsa046120.76088821
89mTOR signaling pathway_Homo sapiens_hsa041500.75627974
90Gastric acid secretion_Homo sapiens_hsa049710.74729416
91Inositol phosphate metabolism_Homo sapiens_hsa005620.74392450
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74345028
93Platelet activation_Homo sapiens_hsa046110.73726278
94N-Glycan biosynthesis_Homo sapiens_hsa005100.73715296
95Type II diabetes mellitus_Homo sapiens_hsa049300.72764183
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72060148
97Pathways in cancer_Homo sapiens_hsa052000.70436621
98ErbB signaling pathway_Homo sapiens_hsa040120.69683815
99Endometrial cancer_Homo sapiens_hsa052130.68734640
100Sphingolipid metabolism_Homo sapiens_hsa006000.68675556
101Salivary secretion_Homo sapiens_hsa049700.67790052
102Focal adhesion_Homo sapiens_hsa045100.67788592
103Primary immunodeficiency_Homo sapiens_hsa053400.67407996
104B cell receptor signaling pathway_Homo sapiens_hsa046620.67062337
105Hepatitis B_Homo sapiens_hsa051610.66919787
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66701516
107Acute myeloid leukemia_Homo sapiens_hsa052210.65707806
108ECM-receptor interaction_Homo sapiens_hsa045120.65431565
109Rap1 signaling pathway_Homo sapiens_hsa040150.65225113
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64632315
111VEGF signaling pathway_Homo sapiens_hsa043700.64497034
112Cholinergic synapse_Homo sapiens_hsa047250.63618473
113Melanoma_Homo sapiens_hsa052180.63407087
114Renin-angiotensin system_Homo sapiens_hsa046140.62592281
115Long-term potentiation_Homo sapiens_hsa047200.61380133
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61378670
117mRNA surveillance pathway_Homo sapiens_hsa030150.60996162
118Glioma_Homo sapiens_hsa052140.60087098
119Dorso-ventral axis formation_Homo sapiens_hsa043200.60024072
120Proteoglycans in cancer_Homo sapiens_hsa052050.59602887
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59328603
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59048021
123Lysosome_Homo sapiens_hsa041420.57797397
124Pancreatic cancer_Homo sapiens_hsa052120.56338473
125Taste transduction_Homo sapiens_hsa047420.55384569
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55145464
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.54435460
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54158134
129HIF-1 signaling pathway_Homo sapiens_hsa040660.52249531
130Adherens junction_Homo sapiens_hsa045200.51817221
131Protein digestion and absorption_Homo sapiens_hsa049740.50726635
132GnRH signaling pathway_Homo sapiens_hsa049120.49963261
133Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48833998
134Insulin secretion_Homo sapiens_hsa049110.48739031
135Chronic myeloid leukemia_Homo sapiens_hsa052200.48350788

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