OSBPL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.23226714
2negative regulation of erythrocyte differentiation (GO:0045647)4.65224615
3hemidesmosome assembly (GO:0031581)4.39647524
4collagen fibril organization (GO:0030199)3.95906174
5glomerular visceral epithelial cell development (GO:0072015)3.91048412
6glomerular basement membrane development (GO:0032836)3.90908030
7skin morphogenesis (GO:0043589)3.85581618
8mannose metabolic process (GO:0006013)3.81268431
9protein heterotrimerization (GO:0070208)3.68191456
10glomerular epithelial cell development (GO:0072310)3.65532472
11neuron projection extension involved in neuron projection guidance (GO:1902284)3.45251981
12axon extension involved in axon guidance (GO:0048846)3.45251981
13plasma membrane repair (GO:0001778)3.39436160
14chondrocyte proliferation (GO:0035988)3.33895050
15wound healing, spreading of epidermal cells (GO:0035313)3.24399173
16leukocyte aggregation (GO:0070486)3.21082399
17barbed-end actin filament capping (GO:0051016)3.21064583
18response to muramyl dipeptide (GO:0032495)3.08974509
19response to laminar fluid shear stress (GO:0034616)3.05056537
20response to peptidoglycan (GO:0032494)3.04454710
21protein localization to endosome (GO:0036010)3.03496987
22sequestering of extracellular ligand from receptor (GO:0035581)3.03382441
23semaphorin-plexin signaling pathway (GO:0071526)2.98601214
24epithelial cell-cell adhesion (GO:0090136)2.97605694
25negative regulation of cell killing (GO:0031342)2.97208124
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.97208124
27cytoskeletal anchoring at plasma membrane (GO:0007016)2.94538614
28wound healing, spreading of cells (GO:0044319)2.92869000
29negative regulation of fatty acid transport (GO:2000192)2.89691751
30regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.88750299
31regulation of glomerular filtration (GO:0003093)2.87857543
32atrioventricular valve morphogenesis (GO:0003181)2.87562134
33cellular extravasation (GO:0045123)2.87070971
34positive regulation of histone deacetylation (GO:0031065)2.86531123
35cell adhesion mediated by integrin (GO:0033627)2.85891160
36endodermal cell differentiation (GO:0035987)2.84882270
37positive regulation of receptor recycling (GO:0001921)2.82897595
38cell migration involved in heart development (GO:0060973)2.79401637
39activation of MAPKKK activity (GO:0000185)2.77864440
40surfactant homeostasis (GO:0043129)2.76207561
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.75157520
42positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.72270004
43collagen metabolic process (GO:0032963)2.71639199
44negative regulation of axon extension involved in axon guidance (GO:0048843)2.69097536
45regulation of axon extension involved in axon guidance (GO:0048841)2.68686458
46collagen catabolic process (GO:0030574)2.68347312
47regulation of leukocyte degranulation (GO:0043300)2.67727475
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.66954265
49negative regulation of catenin import into nucleus (GO:0035414)2.66459148
50multicellular organismal macromolecule metabolic process (GO:0044259)2.65994898
51regulation of tight junction assembly (GO:2000810)2.65509762
52regulation of water loss via skin (GO:0033561)2.65382491
53regulation of ARF GTPase activity (GO:0032312)2.65325113
54basement membrane organization (GO:0071711)2.65149266
55vascular endothelial growth factor signaling pathway (GO:0038084)2.65107474
56regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.63060162
57adherens junction assembly (GO:0034333)2.61958778
58metanephric mesenchyme development (GO:0072075)2.61552182
59establishment of skin barrier (GO:0061436)2.60602926
60cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.60554489
61regulation of axon guidance (GO:1902667)2.60413183
62negative regulation of cell size (GO:0045792)2.60354679
63chondrocyte development (GO:0002063)2.59772151
64induction of positive chemotaxis (GO:0050930)2.59722049
65lymphangiogenesis (GO:0001946)2.59543384
66negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.58580921
67cell-substrate junction assembly (GO:0007044)2.58152770
68regulation of ARF protein signal transduction (GO:0032012)2.57751534
69antigen processing and presentation of endogenous antigen (GO:0019883)2.57343853
70renal filtration (GO:0097205)2.56597909
71negative regulation of axon guidance (GO:1902668)2.56236825
72cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.55584748
73multicellular organismal catabolic process (GO:0044243)2.53624300
74negative regulation of glial cell proliferation (GO:0060253)2.53276797
75detection of other organism (GO:0098543)2.53251289
76positive regulation of gamma-delta T cell activation (GO:0046645)2.53184769
77maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.52990593
78vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.52698552
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.52687724
80negative regulation of granulocyte differentiation (GO:0030853)2.52085540
81hypotonic response (GO:0006971)2.51562813
82positive regulation of hormone biosynthetic process (GO:0046886)2.51508365
83protein targeting to plasma membrane (GO:0072661)2.51436129
84UV protection (GO:0009650)2.51119849
85fibril organization (GO:0097435)2.50605822
86multicellular organismal metabolic process (GO:0044236)2.49904481
87regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.49022250
88renal system process involved in regulation of blood volume (GO:0001977)2.48939624
89negative regulation of interleukin-8 production (GO:0032717)2.47809135
90focal adhesion assembly (GO:0048041)2.47625021
91cell-substrate adherens junction assembly (GO:0007045)2.47625021
92bone trabecula formation (GO:0060346)2.47472386
93extracellular matrix assembly (GO:0085029)2.47274225
94detection of bacterium (GO:0016045)2.46381061
95positive regulation of endothelial cell apoptotic process (GO:2000353)2.46370084
96macrophage activation involved in immune response (GO:0002281)2.45744959
97multicellular organismal water homeostasis (GO:0050891)2.45090019
98extracellular matrix disassembly (GO:0022617)2.45054608
99regulation of myeloid leukocyte mediated immunity (GO:0002886)2.45006067
100response to fluid shear stress (GO:0034405)2.44927675
101protein retention in ER lumen (GO:0006621)2.43943581
102modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.43921143
103positive regulation by organism of defense response of other organism involved in symbiotic interact2.43921143
104modulation by symbiont of host immune response (GO:0052553)2.43921143
105positive regulation by symbiont of host defense response (GO:0052509)2.43921143
106modulation by symbiont of host defense response (GO:0052031)2.43921143
107modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.43921143
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.43020902
109planar cell polarity pathway involved in neural tube closure (GO:0090179)2.42174339
110insulin-like growth factor receptor signaling pathway (GO:0048009)2.41758302
111kidney mesenchyme development (GO:0072074)2.41590296
112peptide cross-linking (GO:0018149)2.41317097
113positive regulation of cartilage development (GO:0061036)2.41208553
114regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.40464039
115activation of JUN kinase activity (GO:0007257)2.39472171
116positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.38351344
117regulation of mast cell degranulation (GO:0043304)2.38015328
118cellular response to vitamin (GO:0071295)2.36179214
119chemical homeostasis within a tissue (GO:0048875)2.35392825
120positive regulation of protein deacetylation (GO:0090312)2.34388371
121bundle of His cell to Purkinje myocyte communication (GO:0086069)2.34336016
122cell-cell junction maintenance (GO:0045217)2.34175305
123positive regulation of axon extension (GO:0045773)2.33880662
124regulation of macrophage cytokine production (GO:0010935)2.33556077
125Golgi transport vesicle coating (GO:0048200)2.33505483
126COPI coating of Golgi vesicle (GO:0048205)2.33505483
127keratinization (GO:0031424)2.33378361
128regulation of fatty acid beta-oxidation (GO:0031998)2.32362046
129dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.29440447
130positive regulation of blood vessel endothelial cell migration (GO:0043536)2.29387704
131negative regulation of chondrocyte differentiation (GO:0032331)2.27838816
132protein localization to cell surface (GO:0034394)2.27449679
133positive regulation of epithelial to mesenchymal transition (GO:0010718)2.26895112
134negative regulation of myotube differentiation (GO:0010832)2.26531273
135positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.26054846
136regulation of regulated secretory pathway (GO:1903305)2.25381775
137gland morphogenesis (GO:0022612)2.24652343
138apoptotic process involved in morphogenesis (GO:0060561)2.24155693
139positive thymic T cell selection (GO:0045059)2.23587498
140regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.23360278
141extracellular fibril organization (GO:0043206)2.22893156
142keratinocyte proliferation (GO:0043616)2.22202952
143ganglion development (GO:0061548)2.21544590
144glomerulus development (GO:0032835)2.21167741
145cellular response to vitamin D (GO:0071305)2.20546189
146cardiac muscle cell proliferation (GO:0060038)2.19760336
147chondroitin sulfate biosynthetic process (GO:0030206)2.19312677
148positive regulation of Cdc42 GTPase activity (GO:0043089)2.19235658
149negative regulation of smooth muscle cell migration (GO:0014912)2.19079302
150negative regulation of cartilage development (GO:0061037)2.19051662
151negative regulation of type 2 immune response (GO:0002829)2.18998023
152cell migration involved in sprouting angiogenesis (GO:0002042)2.18938906
153extracellular matrix organization (GO:0030198)2.18663775
154endocardial cushion development (GO:0003197)2.18447910
155myoblast fusion (GO:0007520)2.18292569
156mesodermal cell differentiation (GO:0048333)2.18005351
157pinocytosis (GO:0006907)2.17643116
158neutrophil activation involved in immune response (GO:0002283)2.17536367
159extracellular structure organization (GO:0043062)2.17223436
160glial cell migration (GO:0008347)2.16819294
161retina vasculature morphogenesis in camera-type eye (GO:0061299)2.16705012
162hippo signaling (GO:0035329)2.16489260
163cortical actin cytoskeleton organization (GO:0030866)2.16147771
164skin development (GO:0043588)2.15480586
165regulation of p38MAPK cascade (GO:1900744)2.15375561
166limb bud formation (GO:0060174)2.15107449
167positive regulation of extracellular matrix organization (GO:1903055)2.14608921
168thymic T cell selection (GO:0045061)2.14187603
169detection of external biotic stimulus (GO:0098581)2.13959492
170negative regulation of phagocytosis (GO:0050765)2.13051766
171embryonic process involved in female pregnancy (GO:0060136)2.12920345
172regulation of cardioblast differentiation (GO:0051890)2.12864048
173lymph vessel development (GO:0001945)2.12858684
174regulation of cartilage development (GO:0061035)2.12846363
175regulation of lipid kinase activity (GO:0043550)2.12637054
176regulation of glucose import in response to insulin stimulus (GO:2001273)2.11937238
177regulation of extracellular matrix disassembly (GO:0010715)2.11679700
178regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.11594908
179keratinocyte differentiation (GO:0030216)2.10880331
180negative regulation of cell fate specification (GO:0009996)2.10369487
181regulation of integrin-mediated signaling pathway (GO:2001044)2.09252150
182stress fiber assembly (GO:0043149)2.09214630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.05292843
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.96730149
3* VDR_21846776_ChIP-Seq_THP-1_Human3.28713890
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.02429157
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.98662298
6* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.61926588
7* KDM2B_26808549_Chip-Seq_DND41_Human2.46251592
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.45549540
9* TCF7_22412390_ChIP-Seq_EML_Mouse2.31062566
10VDR_24763502_ChIP-Seq_THP-1_Human2.30395343
11MYC_22102868_ChIP-Seq_BL_Human2.14165840
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10545985
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.08000109
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06301914
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06301914
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05131317
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03561783
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02530132
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.00884870
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99435398
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96641433
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.89687050
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87538406
24* KDM2B_26808549_Chip-Seq_JURKAT_Human1.86335952
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84864194
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83770673
27* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.81150313
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80240569
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.80095525
30EZH2_22144423_ChIP-Seq_EOC_Human1.79917876
31CJUN_26792858_Chip-Seq_BT549_Human1.76363847
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.75805661
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.74599388
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.72801022
35* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72196985
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70886558
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70380225
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69673444
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68960778
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.68814182
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68768194
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67640409
43* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63199588
44* EZH2_27294783_Chip-Seq_ESCs_Mouse1.61234797
45CLOCK_20551151_ChIP-Seq_293T_Human1.59840094
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.59087770
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58141468
48* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57578930
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56460979
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.55173024
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54689086
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54146550
53MAF_26560356_Chip-Seq_TH1_Human1.54076230
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.52800493
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52661311
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50314218
57* UTX_26944678_Chip-Seq_JUKART_Human1.49670145
58P68_20966046_ChIP-Seq_HELA_Human1.49388972
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.48230027
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.47179576
61AHR_22903824_ChIP-Seq_MCF-7_Human1.44430809
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.43180017
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42334669
64AR_21572438_ChIP-Seq_LNCaP_Human1.41723029
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41692766
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41132039
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41114246
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41062996
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.40415286
70MAF_26560356_Chip-Seq_TH2_Human1.39959211
71TP53_18474530_ChIP-ChIP_U2OS_Human1.38553854
72* SMC4_20622854_ChIP-Seq_HELA_Human1.36654647
73ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34366274
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33829657
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33536327
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33141152
77P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33001378
78CREB1_26743006_Chip-Seq_LNCaP_Human1.32792788
79* DROSHA_22980978_ChIP-Seq_HELA_Human1.32198792
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31602495
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.31082202
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31072617
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31072617
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.30041204
85SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29429981
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28165585
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.27158249
88NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26650248
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.26438766
90SPI1_23127762_ChIP-Seq_K562_Human1.26186924
91KDM2B_26808549_Chip-Seq_K562_Human1.25671010
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24786476
93PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23895058
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23666839
95* SOX2_20726797_ChIP-Seq_SW620_Human1.21429435
96* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20404426
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20240591
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.20121865
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19863272
100ZNF263_19887448_ChIP-Seq_K562_Human1.19272833
101TP53_22127205_ChIP-Seq_IMR90_Human1.17927130
102CTCF_27219007_Chip-Seq_Bcells_Human1.15008758
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13441458
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.13114107
105MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13031501
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12809230
107ELF1_20517297_ChIP-Seq_JURKAT_Human1.11322906
108SCL_19346495_ChIP-Seq_HPC-7_Human1.10717228
109TBX20_22080862_ChIP-Seq_HEART_Mouse1.09795147
110TBX20_22328084_ChIP-Seq_HEART_Mouse1.09795147
111NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09572946
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09572946
113GATA1_19941826_ChIP-Seq_K562_Human1.08426969
114STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07668861
115JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07655666
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06982273
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06893295
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06891486
119KLF5_25053715_ChIP-Seq_YYC3_Human1.06782594
120KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05378077
121BCOR_27268052_Chip-Seq_Bcells_Human1.05284699
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04519494
123RXR_22108803_ChIP-Seq_LS180_Human1.03908755
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03279535
125KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02650298
126* NCOR1_26117541_ChIP-Seq_K562_Human1.02409043
127BCL6_27268052_Chip-Seq_Bcells_Human1.02149313
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02129614
129CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01827956
130IRF8_22096565_ChIP-ChIP_GC-B_Human1.01650846
131TET1_21490601_ChIP-Seq_MESCs_Mouse1.01637999
132RING1B_27294783_Chip-Seq_ESCs_Mouse1.01590905
133NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01543888
134* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00023072
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99506631
136* LXR_22292898_ChIP-Seq_THP-1_Human0.98689403
137RING1B_27294783_Chip-Seq_NPCs_Mouse0.98114337
138BRD4_25478319_ChIP-Seq_HGPS_Human0.98051816
139P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97682342
140JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97488154
141FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97109932
142IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96843505
143RACK7_27058665_Chip-Seq_MCF-7_Human0.96301968
144TP53_23651856_ChIP-Seq_MEFs_Mouse0.95235400
145* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95054513
146EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95033085
147* UBF1/2_26484160_Chip-Seq_HMECs_Human0.95002164
148ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94082855
149NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92502736
150ERG_21242973_ChIP-ChIP_JURKAT_Human0.91935597
151PIAS1_25552417_ChIP-Seq_VCAP_Human0.91177202
152TP63_23658742_ChIP-Seq_EP156T_Human0.91070168
153RUNX1_27514584_Chip-Seq_MCF-7_Human0.90073469
154PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89510166
155* ISL1_27105846_Chip-Seq_CPCs_Mouse0.89084369
156CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88629037
157NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86972282
158ELK3_25401928_ChIP-Seq_HUVEC_Human0.86171573
159DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85875703
160TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85832363
161TCF4_18268006_ChIP-ChIP_LS174T_Human0.85061506
162OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83984132
163TP53_16413492_ChIP-PET_HCT116_Human0.82844375
164HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82259983
165TP63_22573176_ChIP-Seq_HFKS_Human0.82155512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile4.93763478
2MP0008438_abnormal_cutaneous_collagen4.79645537
3MP0001958_emphysema3.09000928
4MP0004272_abnormal_basement_membrane3.03702331
5MP0005503_abnormal_tendon_morphology2.98166554
6MP0003279_aneurysm2.77789694
7MP0003705_abnormal_hypodermis_morpholog2.65030911
8MP0000013_abnormal_adipose_tissue2.62778998
9MP0002796_impaired_skin_barrier2.56784140
10MP0005623_abnormal_meninges_morphology2.55699760
11MP0003436_decreased_susceptibility_to2.46086273
12MP0009384_cardiac_valve_regurgitation2.41747266
13MP0010234_abnormal_vibrissa_follicle2.38334203
14MP0005058_abnormal_lysosome_morphology2.35557591
15MP0006054_spinal_hemorrhage2.07313481
16MP0005076_abnormal_cell_differentiation2.05891913
17MP0003941_abnormal_skin_development2.04661114
18MP0002060_abnormal_skin_morphology2.04633551
19MP0000579_abnormal_nail_morphology2.02189469
20MP0003566_abnormal_cell_adhesion2.00918262
21MP0003172_abnormal_lysosome_physiology1.95516004
22MP0005409_darkened_coat_color1.94504443
23MP0002877_abnormal_melanocyte_morpholog1.93725287
24MP0009780_abnormal_chondrocyte_physiolo1.89153313
25MP0003303_peritoneal_inflammation1.88355153
26MP0010386_abnormal_urinary_bladder1.84260356
27MP0009278_abnormal_bone_marrow1.84042105
28MP0003724_increased_susceptibility_to1.83362457
29MP0008260_abnormal_autophagy1.83045826
30MP0004947_skin_inflammation1.76799758
31MP0003191_abnormal_cellular_cholesterol1.71859034
32MP0010030_abnormal_orbit_morphology1.68812913
33MP0005501_abnormal_skin_physiology1.55850941
34MP0001542_abnormal_bone_strength1.53645399
35MP0002896_abnormal_bone_mineralization1.52620568
36MP0000858_altered_metastatic_potential1.51608725
37MP0003828_pulmonary_edema1.50587959
38MP0002295_abnormal_pulmonary_circulatio1.49712389
39MP0001533_abnormal_skeleton_physiology1.49186404
40MP0005508_abnormal_skeleton_morphology1.47940406
41MP0003942_abnormal_urinary_system1.47268900
42MP0001299_abnormal_eye_distance/1.43248387
43MP0002419_abnormal_innate_immunity1.42343593
44MP0000751_myopathy1.41987424
45MP0002249_abnormal_larynx_morphology1.41391752
46MP0009250_abnormal_appendicular_skeleto1.40891371
47MP0000003_abnormal_adipose_tissue1.40208440
48MP0003091_abnormal_cell_migration1.39743217
49MP0000762_abnormal_tongue_morphology1.39360237
50MP0003283_abnormal_digestive_organ1.39041559
51MP0000537_abnormal_urethra_morphology1.38950582
52MP0000534_abnormal_ureter_morphology1.37866384
53MP0004510_myositis1.37265644
54MP0003385_abnormal_body_wall1.33617351
55MP0004381_abnormal_hair_follicle1.33051370
56MP0004185_abnormal_adipocyte_glucose1.31472409
57MP0003045_fibrosis1.30274719
58MP0000538_abnormal_urinary_bladder1.29150987
59MP0006082_CNS_inflammation1.29118366
60MP0010771_integument_phenotype1.25608968
61MP0002234_abnormal_pharynx_morphology1.24457437
62MP0005451_abnormal_body_composition1.24061903
63MP0005666_abnormal_adipose_tissue1.23304395
64MP0003763_abnormal_thymus_physiology1.21346335
65MP0002098_abnormal_vibrissa_morphology1.18588500
66MP0002108_abnormal_muscle_morphology1.17163048
67MP0002837_dystrophic_cardiac_calcinosis1.16678812
68MP0005025_abnormal_response_to1.16618716
69MP0004858_abnormal_nervous_system1.16609858
70MP0000767_abnormal_smooth_muscle1.12839724
71MP0005257_abnormal_intraocular_pressure1.11229749
72MP0005023_abnormal_wound_healing1.10138622
73MP0000163_abnormal_cartilage_morphology1.08822691
74MP0004130_abnormal_muscle_cell1.08749745
75MP0005164_abnormal_response_to1.08428605
76MP0001177_atelectasis1.07922135
77MP0000467_abnormal_esophagus_morphology1.07764581
78MP0002282_abnormal_trachea_morphology1.06683799
79MP0001346_abnormal_lacrimal_gland1.06277789
80MP0001879_abnormal_lymphatic_vessel1.05055623
81MP0000733_abnormal_muscle_development1.04526946
82MP0003453_abnormal_keratinocyte_physiol1.00655667
83MP0005367_renal/urinary_system_phenotyp0.99235093
84MP0000516_abnormal_urinary_system0.99235093
85MP0001216_abnormal_epidermal_layer0.98542043
86MP0001270_distended_abdomen0.97943107
87MP0003115_abnormal_respiratory_system0.97075123
88MP0004084_abnormal_cardiac_muscle0.96612601
89MP0005388_respiratory_system_phenotype0.95413893
90MP0002133_abnormal_respiratory_system0.95413893
91MP0010368_abnormal_lymphatic_system0.94807136
92MP0001835_abnormal_antigen_presentation0.93942125
93MP0002396_abnormal_hematopoietic_system0.93259460
94MP0001348_abnormal_lacrimal_gland0.93202960
95MP0000750_abnormal_muscle_regeneration0.91427353
96MP0003448_altered_tumor_morphology0.91338076
97MP0001243_abnormal_dermal_layer0.90274524
98MP0001851_eye_inflammation0.89957250
99MP0000377_abnormal_hair_follicle0.89185317
100MP0005375_adipose_tissue_phenotype0.89073576
101MP0002115_abnormal_skeleton_extremities0.88870603
102MP0004134_abnormal_chest_morphology0.88502326
103MP0010678_abnormal_skin_adnexa0.88398603
104MP0000383_abnormal_hair_follicle0.87964696
105MP0008961_abnormal_basal_metabolism0.87900821
106MP0003755_abnormal_palate_morphology0.87503268
107MP0005464_abnormal_platelet_physiology0.86915761
108MP0002998_abnormal_bone_remodeling0.86549401
109MP0002233_abnormal_nose_morphology0.81537492
110MP0002420_abnormal_adaptive_immunity0.81527496
111MP0001819_abnormal_immune_cell0.81290904
112MP0002089_abnormal_postnatal_growth/wei0.81289668
113MP0009931_abnormal_skin_appearance0.81195975
114MP0003329_amyloid_beta_deposits0.80489378
115MP0000678_abnormal_parathyroid_gland0.80430025
116MP0003795_abnormal_bone_structure0.80289433
117MP0000049_abnormal_middle_ear0.80274807
118MP0002933_joint_inflammation0.80020568
119MP0003300_gastrointestinal_ulcer0.79933020
120MP0005397_hematopoietic_system_phenotyp0.79881244
121MP0001545_abnormal_hematopoietic_system0.79881244
122MP0004808_abnormal_hematopoietic_stem0.79842550
123MP0010155_abnormal_intestine_physiology0.79692080
124MP0000428_abnormal_craniofacial_morphol0.79654673
125MP0009840_abnormal_foam_cell0.79381031
126MP0005000_abnormal_immune_tolerance0.78972262
127MP0000462_abnormal_digestive_system0.78616423
128MP0000749_muscle_degeneration0.78595904
129MP0001849_ear_inflammation0.77358801
130MP0004883_abnormal_blood_vessel0.77100351
131MP0006138_congestive_heart_failure0.76878544
132MP0002405_respiratory_system_inflammati0.76847624
133MP0008004_abnormal_stomach_pH0.76490440
134MP0005595_abnormal_vascular_smooth0.75297786
135MP0003183_abnormal_peptide_metabolism0.75203951
136MP0004087_abnormal_muscle_fiber0.74981059
137MP0009053_abnormal_anal_canal0.74823598
138MP0002932_abnormal_joint_morphology0.74063729
139MP0000759_abnormal_skeletal_muscle0.73704239
140MP0000249_abnormal_blood_vessel0.72927709
141MP0003075_altered_response_to0.72748740
142MP0002113_abnormal_skeleton_development0.72427883
143MP0000566_synostosis0.72066777
144MP0002166_altered_tumor_susceptibility0.71924257
145MP0001984_abnormal_olfaction0.71469916
146MP0005390_skeleton_phenotype0.71290106
147MP0002177_abnormal_outer_ear0.71174938
148MP0009379_abnormal_foot_pigmentation0.70515313
149MP0010352_gastrointestinal_tract_polyps0.70507721
150MP0002452_abnormal_antigen_presenting0.70110175
151MP0000465_gastrointestinal_hemorrhage0.69840103
152MP0005621_abnormal_cell_physiology0.69519047

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.78367953
2Protrusio acetabuli (HP:0003179)4.98552469
3Atrophic scars (HP:0001075)4.78411321
4Aortic dissection (HP:0002647)3.92147575
5Fragile skin (HP:0001030)3.86021686
6Broad metatarsal (HP:0001783)3.81238202
7Shallow orbits (HP:0000586)3.73154987
8Aortic aneurysm (HP:0004942)3.72516529
9Obstructive sleep apnea (HP:0002870)3.52868049
10Right ventricular cardiomyopathy (HP:0011663)3.39805026
11Cerebral aneurysm (HP:0004944)3.34930208
12Type 1 muscle fiber predominance (HP:0003803)3.23174580
13Ankle contracture (HP:0006466)3.20027849
14Vascular tortuosity (HP:0004948)3.18013350
15Broad face (HP:0000283)3.14433856
16Abnormality of dentin (HP:0010299)3.13797248
17Dilatation of the ascending aorta (HP:0005111)3.01087820
18Soft skin (HP:0000977)2.98238779
19Eczematoid dermatitis (HP:0000976)2.94666802
20Spinal rigidity (HP:0003306)2.90064235
21Follicular hyperkeratosis (HP:0007502)2.80178452
22Neonatal short-limb short stature (HP:0008921)2.75886229
23Wormian bones (HP:0002645)2.75735894
24Milia (HP:0001056)2.75669383
25Short nail (HP:0001799)2.73541045
26Increased connective tissue (HP:0009025)2.69564947
27Bladder diverticulum (HP:0000015)2.66111225
28Arterial tortuosity (HP:0005116)2.63421173
29Mildly elevated creatine phosphokinase (HP:0008180)2.59215930
30Increased variability in muscle fiber diameter (HP:0003557)2.54781516
31Thin bony cortex (HP:0002753)2.53124746
32Cervical subluxation (HP:0003308)2.46609584
33Hyperacusis (HP:0010780)2.46262955
34Hyporeflexia of lower limbs (HP:0002600)2.44654652
35Joint stiffness (HP:0001387)2.44583498
36Aortic regurgitation (HP:0001659)2.34357623
37Mitral regurgitation (HP:0001653)2.33059241
38Onycholysis (HP:0001806)2.31244982
39Scapular winging (HP:0003691)2.30587568
40Disproportionate tall stature (HP:0001519)2.29710761
41Abnormality of skeletal muscle fiber size (HP:0012084)2.27420834
42Biconcave vertebral bodies (HP:0004586)2.21665176
43Aplasia involving bones of the extremities (HP:0009825)2.20256394
44Aplasia involving bones of the upper limbs (HP:0009823)2.20256394
45Aplasia of the phalanges of the hand (HP:0009802)2.20256394
46Peritonitis (HP:0002586)2.20218271
47Increased IgE level (HP:0003212)2.19713961
48Fragile nails (HP:0001808)2.18080723
49Wrist flexion contracture (HP:0001239)2.15518319
50Dysostosis multiplex (HP:0000943)2.13408964
51Bronchomalacia (HP:0002780)2.12908550
52Mitral valve prolapse (HP:0001634)2.10801687
53Aneurysm (HP:0002617)2.10090747
54Slender build (HP:0001533)2.09678519
55Blue sclerae (HP:0000592)2.08955176
56Hyperextensible skin (HP:0000974)2.06623004
57Muscle fiber splitting (HP:0003555)2.06233839
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04372342
59Abnormality of polysaccharide metabolism (HP:0011012)2.04372342
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04372342
61Morphological abnormality of the middle ear (HP:0008609)2.03062865
62Cellulitis (HP:0100658)2.02275594
63Natal tooth (HP:0000695)2.02265882
64Difficulty climbing stairs (HP:0003551)2.01408235
65Overgrowth (HP:0001548)1.99710973
66Gingivitis (HP:0000230)1.99543990
67Urinary glycosaminoglycan excretion (HP:0003541)1.98797217
68Mucopolysacchariduria (HP:0008155)1.98797217
69Mesangial abnormality (HP:0001966)1.96486732
70Hypotrichosis (HP:0001006)1.95955208
71Abnormality of macrophages (HP:0004311)1.93573520
72Achilles tendon contracture (HP:0001771)1.92451825
73Amyloidosis (HP:0011034)1.92045389
74Bradycardia (HP:0001662)1.91736965
75Buphthalmos (HP:0000557)1.90598763
76Advanced eruption of teeth (HP:0006288)1.89231894
77Flat acetabular roof (HP:0003180)1.88474516
78Tibial bowing (HP:0002982)1.88000063
79Vertebral compression fractures (HP:0002953)1.87513382
80Wide anterior fontanel (HP:0000260)1.87291329
81Distal lower limb amyotrophy (HP:0008944)1.86580812
82Pterygium (HP:0001059)1.85825574
83Ulnar bowing (HP:0003031)1.84591710
84Hemorrhage of the eye (HP:0011885)1.84517896
85Round ear (HP:0100830)1.84182804
86Interstitial pulmonary disease (HP:0006530)1.83890137
87Long toe (HP:0010511)1.83737265
88Bell-shaped thorax (HP:0001591)1.83247766
89Myositis (HP:0100614)1.82503971
90Ectopia lentis (HP:0001083)1.82465120
91Joint laxity (HP:0001388)1.82142076
92Hypoplasia of the iris (HP:0007676)1.81960031
93Elevated erythrocyte sedimentation rate (HP:0003565)1.81269212
94Spontaneous hematomas (HP:0007420)1.81049719
95Bowel diverticulosis (HP:0005222)1.80424614
96Recurrent abscess formation (HP:0002722)1.79888237
97Exostoses (HP:0100777)1.79827744
98Distal lower limb muscle weakness (HP:0009053)1.78857714
99Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.78554430
100Osteolytic defects of the phalanges of the hand (HP:0009771)1.75418140
101Osteolytic defects of the hand bones (HP:0009699)1.75418140
102Asymmetric septal hypertrophy (HP:0001670)1.75351691
103Aortic valve stenosis (HP:0001650)1.74449528
104Abnormality of the calf musculature (HP:0001430)1.73787495
105Spinal cord lesions (HP:0100561)1.73524927
106Syringomyelia (HP:0003396)1.73524927
107Plantar hyperkeratosis (HP:0007556)1.73213502
108Broad ribs (HP:0000885)1.72846032
109Premature skin wrinkling (HP:0100678)1.72447370
110Atelectasis (HP:0100750)1.72419910
111Bowed forearm bones (HP:0003956)1.71945389
112Bowing of the arm (HP:0006488)1.71945389
113Elbow flexion contracture (HP:0002987)1.71036176
114Genu recurvatum (HP:0002816)1.70876964
115Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70531180
116Congenital glaucoma (HP:0001087)1.70292226
117Hypertriglyceridemia (HP:0002155)1.69451444
118J-shaped sella turcica (HP:0002680)1.69327175
119Coronal craniosynostosis (HP:0004440)1.69286173
120Radial bowing (HP:0002986)1.69069283
121Lower limb amyotrophy (HP:0007210)1.68316400
122Hypoventilation (HP:0002791)1.68263531
123Alopecia of scalp (HP:0002293)1.68242593
124Hyperactive renin-angiotensin system (HP:0000841)1.68217534
125Recurrent bacterial skin infections (HP:0005406)1.67914163
126Osteoarthritis (HP:0002758)1.67890749
127Mesomelia (HP:0003027)1.67656224
128Abnormality of the thoracic spine (HP:0100711)1.67213600
129Easy fatigability (HP:0003388)1.67161049
130Tarsal synostosis (HP:0008368)1.67007355
131Distal upper limb amyotrophy (HP:0007149)1.66822702
132Upper limb amyotrophy (HP:0009129)1.66822702
133Muscle fiber inclusion bodies (HP:0100299)1.65856105
134Lymphangioma (HP:0100764)1.65690365
135Persistence of primary teeth (HP:0006335)1.65623116
136Stridor (HP:0010307)1.65200816
137Femoral bowing (HP:0002980)1.65102783
138Spondylolisthesis (HP:0003302)1.65055840
139Spinal cord compression (HP:0002176)1.64108866
140Camptodactyly of toe (HP:0001836)1.63919439
141Abnormality of liposaccharide metabolism (HP:0010968)1.63626513
142Abnormality of glycosphingolipid metabolism (HP:0004343)1.63626513
143Abnormality of glycolipid metabolism (HP:0010969)1.63626513
144Generalized amyotrophy (HP:0003700)1.62748342
145Craniofacial hyperostosis (HP:0004493)1.62725864
146Short hallux (HP:0010109)1.62513173
147Knee flexion contracture (HP:0006380)1.61990977
148Abnormality of skull ossification (HP:0002703)1.61911206
149Annular pancreas (HP:0001734)1.61780345
150Supranuclear gaze palsy (HP:0000605)1.61725124
151Stage 5 chronic kidney disease (HP:0003774)1.61259486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.52224529
2TTN3.11070832
3PRPF4B3.03439748
4EPHA32.89661988
5RIPK12.65632036
6EPHB22.58529667
7PDGFRA2.46814824
8DDR22.46606824
9MAP3K32.43786721
10FER2.40389798
11MAP3K61.94541607
12MYLK1.93727290
13ERN11.90796566
14TGFBR21.88346628
15ICK1.85396741
16LIMK11.82453576
17LATS21.74575605
18TNK21.73492463
19SMG11.72989386
20RIPK41.67225714
21PAK31.66796657
22TRPM71.66779768
23MAPKAPK31.64474533
24LATS11.63756031
25EEF2K1.63658844
26EPHA21.63637538
27ERBB31.55133248
28WNK41.50652523
29PTK21.49194404
30MST1R1.44917385
31DMPK1.43430138
32MAP4K11.42967538
33NTRK11.42591288
34EPHB11.39416461
35TAOK11.33380590
36FGFR21.33044206
37PTK61.29460470
38MAP3K131.28443298
39PKN21.27820616
40MAP3K111.27706929
41TESK11.25656318
42CDK121.25170048
43TYK21.23380859
44ILK1.19239973
45CDC42BPA1.18503613
46GRK61.16972172
47SIK11.15092146
48MAP3K71.13726345
49FES1.13246212
50PAK21.08572031
51LRRK21.08300504
52KIT1.07963573
53CSK1.07884651
54ROCK11.07640247
55IRAK31.06888800
56PDGFRB1.04626665
57MAP2K11.03364882
58PHKG11.03344376
59PHKG21.03344376
60BLK0.99171742
61STK240.98431153
62TBK10.96125184
63MARK10.95621799
64MAP2K30.94820821
65PRKCH0.92485715
66MET0.91229030
67FGFR40.90143883
68PRKD10.88861611
69PIM20.87301629
70MAPK70.86626687
71SIK20.83519086
72RPS6KA20.83510086
73PIK3CG0.82813429
74RET0.82496244
75PRKD30.82396410
76TIE10.80524805
77FGFR10.80476363
78JAK10.80282226
79PTK2B0.80033266
80RPS6KC10.79860223
81RPS6KL10.79860223
82MARK20.79853132
83PDPK10.78458711
84HCK0.78419021
85STK100.76970375
86BTK0.76540354
87IRAK40.74896348
88PRKD20.72390584
89MAP3K20.72325539
90FGFR30.71921083
91NTRK30.71600870
92ROCK20.71280043
93MAPK150.70910329
94JAK30.70311962
95PAK40.70139058
96HIPK20.63497726
97WNK10.62407258
98PRKCE0.62319145
99MAPKAPK50.62145373
100KSR20.61794497
101RPS6KA60.61537943
102CAMKK10.61418795
103LMTK20.60007270
104MAP3K140.59188427
105STK38L0.58605271
106MAP3K100.58505720
107CAMK1D0.57068875
108MOS0.56433725
109PAK60.54713574
110BMX0.54470396
111PIK3CA0.53839416
112STK380.53172164
113ADRBK10.52579031
114MAPK40.50965473
115TAOK20.50297699
116MARK30.48589149
117IRAK20.46139266
118DYRK1B0.45619609
119MAP3K10.45318612
120PDK10.44707245
121MINK10.44484702
122FYN0.44373089
123TESK20.44040073
124MAP2K40.43862644
125MTOR0.43492313
126CDK60.43029564
127STK110.42605589
128MAPK120.42545740
129ZAP700.42470668
130CSNK1A1L0.40775845
131MST40.40648210
132SRC0.40401058
133PRKG20.39164799
134LCK0.36836186
135DAPK30.35964403
136NME10.35812305
137GSK3A0.35656239
138FRK0.33704605
139MAP2K60.33051564
140MAPKAPK20.33047310
141CAMK2B0.32910957
142NTRK20.32676061
143CDK50.31455079
144INSR0.31347373
145MAPK130.30886645

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.96117357
2Other glycan degradation_Homo sapiens_hsa005112.26251412
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.15434949
4Focal adhesion_Homo sapiens_hsa045102.08162192
5Acute myeloid leukemia_Homo sapiens_hsa052211.95834199
6Dilated cardiomyopathy_Homo sapiens_hsa054141.94687853
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.85331933
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.81295608
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73579469
10Protein digestion and absorption_Homo sapiens_hsa049741.70415614
11Osteoclast differentiation_Homo sapiens_hsa043801.70031137
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.66825610
13Axon guidance_Homo sapiens_hsa043601.65598639
14Proteoglycans in cancer_Homo sapiens_hsa052051.58410613
15Amoebiasis_Homo sapiens_hsa051461.54088158
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51900192
17Adherens junction_Homo sapiens_hsa045201.50796972
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47539960
19Hippo signaling pathway_Homo sapiens_hsa043901.45866781
20Vibrio cholerae infection_Homo sapiens_hsa051101.41456482
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40458554
22Bladder cancer_Homo sapiens_hsa052191.38205107
23Tight junction_Homo sapiens_hsa045301.37868138
24Malaria_Homo sapiens_hsa051441.34568696
25Non-small cell lung cancer_Homo sapiens_hsa052231.34028879
26Basal cell carcinoma_Homo sapiens_hsa052171.31041291
27Olfactory transduction_Homo sapiens_hsa047401.28259937
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27480338
29B cell receptor signaling pathway_Homo sapiens_hsa046621.27094328
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23945678
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.20964796
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20195667
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19790003
34Leishmaniasis_Homo sapiens_hsa051401.19774136
35TNF signaling pathway_Homo sapiens_hsa046681.16054505
36Hedgehog signaling pathway_Homo sapiens_hsa043401.15127056
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14526931
38Choline metabolism in cancer_Homo sapiens_hsa052311.13053578
39Melanogenesis_Homo sapiens_hsa049161.11785050
40Small cell lung cancer_Homo sapiens_hsa052221.10286195
41Rap1 signaling pathway_Homo sapiens_hsa040151.10174076
42mTOR signaling pathway_Homo sapiens_hsa041501.09534178
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09210049
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08451314
45GnRH signaling pathway_Homo sapiens_hsa049121.07622969
46Insulin secretion_Homo sapiens_hsa049111.07033161
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06415211
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.04525945
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03638771
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03431799
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02583632
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02227108
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02024688
54Gastric acid secretion_Homo sapiens_hsa049711.00015752
55PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99475219
56Hepatitis C_Homo sapiens_hsa051600.96949630
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96629837
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.95518338
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95106131
60Hepatitis B_Homo sapiens_hsa051610.94201990
61Gap junction_Homo sapiens_hsa045400.93819520
62Cocaine addiction_Homo sapiens_hsa050300.93688733
63Pancreatic cancer_Homo sapiens_hsa052120.93034887
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92868827
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91343893
66TGF-beta signaling pathway_Homo sapiens_hsa043500.91289542
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91190195
68Estrogen signaling pathway_Homo sapiens_hsa049150.91014896
69Platelet activation_Homo sapiens_hsa046110.90290684
70Glioma_Homo sapiens_hsa052140.90112640
71Renin secretion_Homo sapiens_hsa049240.89745056
72Tuberculosis_Homo sapiens_hsa051520.89507268
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.88286659
74Chemokine signaling pathway_Homo sapiens_hsa040620.87939948
75VEGF signaling pathway_Homo sapiens_hsa043700.87909008
76Renal cell carcinoma_Homo sapiens_hsa052110.87632092
77Wnt signaling pathway_Homo sapiens_hsa043100.87468752
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86523015
79T cell receptor signaling pathway_Homo sapiens_hsa046600.85277582
80Chronic myeloid leukemia_Homo sapiens_hsa052200.85014972
81Collecting duct acid secretion_Homo sapiens_hsa049660.84892843
82Viral myocarditis_Homo sapiens_hsa054160.84815527
83Melanoma_Homo sapiens_hsa052180.83988126
84Cholinergic synapse_Homo sapiens_hsa047250.83613092
85Ras signaling pathway_Homo sapiens_hsa040140.83391069
86Sphingolipid metabolism_Homo sapiens_hsa006000.83159746
87Taste transduction_Homo sapiens_hsa047420.83111161
88Endometrial cancer_Homo sapiens_hsa052130.82989956
89Synaptic vesicle cycle_Homo sapiens_hsa047210.82232622
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80483296
91Shigellosis_Homo sapiens_hsa051310.79839054
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79490774
93Inositol phosphate metabolism_Homo sapiens_hsa005620.78965636
94Pertussis_Homo sapiens_hsa051330.78832252
95AMPK signaling pathway_Homo sapiens_hsa041520.78587419
96Oxytocin signaling pathway_Homo sapiens_hsa049210.78505169
97Thyroid hormone synthesis_Homo sapiens_hsa049180.78436583
98Salivary secretion_Homo sapiens_hsa049700.78198154
99Circadian entrainment_Homo sapiens_hsa047130.78100661
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.77882701
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77789458
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75497425
103Apoptosis_Homo sapiens_hsa042100.75342196
104Pathways in cancer_Homo sapiens_hsa052000.75003174
105Prolactin signaling pathway_Homo sapiens_hsa049170.74368181
106Influenza A_Homo sapiens_hsa051640.73668936
107MicroRNAs in cancer_Homo sapiens_hsa052060.73390385
108cAMP signaling pathway_Homo sapiens_hsa040240.71784403
109Dopaminergic synapse_Homo sapiens_hsa047280.71286100
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70681675
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70243477
112Toxoplasmosis_Homo sapiens_hsa051450.70160337
113N-Glycan biosynthesis_Homo sapiens_hsa005100.69529236
114Ovarian steroidogenesis_Homo sapiens_hsa049130.68756406
115Endocytosis_Homo sapiens_hsa041440.68731402
116ErbB signaling pathway_Homo sapiens_hsa040120.68444394
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67919886
118Phagosome_Homo sapiens_hsa041450.65984753
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64800008
120MAPK signaling pathway_Homo sapiens_hsa040100.64589002
121Lysosome_Homo sapiens_hsa041420.63193284
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61785648
123Prostate cancer_Homo sapiens_hsa052150.61446499
124Thyroid cancer_Homo sapiens_hsa052160.61250017
125HTLV-I infection_Homo sapiens_hsa051660.60929070
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.60525551
127Notch signaling pathway_Homo sapiens_hsa043300.60522934
128Dorso-ventral axis formation_Homo sapiens_hsa043200.59779935
129Prion diseases_Homo sapiens_hsa050200.59758890
130Serotonergic synapse_Homo sapiens_hsa047260.59559782
131Long-term potentiation_Homo sapiens_hsa047200.59499648
132Amphetamine addiction_Homo sapiens_hsa050310.59132622
133Insulin resistance_Homo sapiens_hsa049310.57505947
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.57171204
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.56543467
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.55685229
137Pancreatic secretion_Homo sapiens_hsa049720.51597647
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.51340422
139Salmonella infection_Homo sapiens_hsa051320.51041776
140Calcium signaling pathway_Homo sapiens_hsa040200.50444949
141FoxO signaling pathway_Homo sapiens_hsa040680.49849819
142Insulin signaling pathway_Homo sapiens_hsa049100.49428444
143Colorectal cancer_Homo sapiens_hsa052100.49288405

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