OSBPL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.72955032
2axonemal dynein complex assembly (GO:0070286)5.64414075
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.23706592
4vocalization behavior (GO:0071625)5.20851770
5cilium or flagellum-dependent cell motility (GO:0001539)5.17169856
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.17044199
7synaptic vesicle exocytosis (GO:0016079)4.97597366
8cilium movement (GO:0003341)4.90340889
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.88173451
10synaptic vesicle maturation (GO:0016188)4.74417963
11behavioral response to nicotine (GO:0035095)4.67650177
12protein localization to synapse (GO:0035418)4.66043477
13glutamate secretion (GO:0014047)4.64489353
14locomotory exploration behavior (GO:0035641)4.60490766
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.58558666
16cellular potassium ion homeostasis (GO:0030007)4.55525061
17glutamate receptor signaling pathway (GO:0007215)4.54643968
18regulation of synaptic vesicle exocytosis (GO:2000300)4.52280874
19G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.46551508
20epithelial cilium movement (GO:0003351)4.44657956
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.40202012
22neuron cell-cell adhesion (GO:0007158)4.22927561
23neuronal action potential propagation (GO:0019227)4.19653673
24positive regulation of synapse maturation (GO:0090129)4.17427170
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.14520630
26synaptic transmission, glutamatergic (GO:0035249)4.12873455
27regulation of glutamate receptor signaling pathway (GO:1900449)4.10434742
28regulation of synaptic vesicle transport (GO:1902803)4.09413859
29neurotransmitter secretion (GO:0007269)4.04028219
30motile cilium assembly (GO:0044458)4.02836848
31neuron-neuron synaptic transmission (GO:0007270)4.00973416
32axoneme assembly (GO:0035082)3.99743863
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.91830527
34sodium ion export (GO:0071436)3.91573622
35gamma-aminobutyric acid signaling pathway (GO:0007214)3.89080267
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.87109255
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.75578731
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.72186986
39cerebellar Purkinje cell differentiation (GO:0021702)3.70526852
40exploration behavior (GO:0035640)3.65271413
41regulation of cilium movement (GO:0003352)3.64514977
42positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.63190641
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.62222610
44synaptic vesicle endocytosis (GO:0048488)3.60906595
45regulation of neuronal synaptic plasticity (GO:0048168)3.59584784
46layer formation in cerebral cortex (GO:0021819)3.58845593
47long-term memory (GO:0007616)3.58470419
48cerebellar granule cell differentiation (GO:0021707)3.58221350
49membrane depolarization during action potential (GO:0086010)3.52366151
50neurotransmitter transport (GO:0006836)3.51891432
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.51439092
52neurotransmitter-gated ion channel clustering (GO:0072578)3.50409472
53neuron recognition (GO:0008038)3.44813952
54innervation (GO:0060384)3.44134799
55cell communication by electrical coupling (GO:0010644)3.42182101
56regulation of postsynaptic membrane potential (GO:0060078)3.41679732
57positive regulation of membrane potential (GO:0045838)3.40428004
58long-term synaptic potentiation (GO:0060291)3.39278774
59regulation of synapse structural plasticity (GO:0051823)3.38610628
60proline transport (GO:0015824)3.36552442
61regulation of synapse maturation (GO:0090128)3.36054981
62potassium ion homeostasis (GO:0055075)3.29078393
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.28050953
64regulation of neurotransmitter secretion (GO:0046928)3.27222015
65gamma-aminobutyric acid transport (GO:0015812)3.25864228
66transmission of nerve impulse (GO:0019226)3.25382478
67presynaptic membrane organization (GO:0097090)3.24085288
68response to histamine (GO:0034776)3.23853443
69behavioral fear response (GO:0001662)3.22573371
70behavioral defense response (GO:0002209)3.22573371
71auditory behavior (GO:0031223)3.19399477
72membrane hyperpolarization (GO:0060081)3.18221173
73regulation of vesicle fusion (GO:0031338)3.18088351
74regulation of synaptic plasticity (GO:0048167)3.17413017
75startle response (GO:0001964)3.15819139
76axonal fasciculation (GO:0007413)3.15065970
77protein polyglutamylation (GO:0018095)3.13763432
78regulation of synaptic transmission, glutamatergic (GO:0051966)3.13575592
79cellular sodium ion homeostasis (GO:0006883)3.12457712
80dendritic spine morphogenesis (GO:0060997)3.11717214
81positive regulation of potassium ion transmembrane transport (GO:1901381)3.11568363
82dendrite morphogenesis (GO:0048813)3.10611089
83regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.10110699
84membrane depolarization (GO:0051899)3.09942908
85behavioral response to cocaine (GO:0048148)3.07527760
86response to pheromone (GO:0019236)3.06820858
87cell proliferation in forebrain (GO:0021846)3.05300020
88fear response (GO:0042596)3.05179001
89neuronal action potential (GO:0019228)3.02229610
90regulation of neurotransmitter transport (GO:0051588)3.02001034
91otic vesicle formation (GO:0030916)3.01544352
92regulation of neurotransmitter levels (GO:0001505)3.01375731
93sulfation (GO:0051923)3.00216074
94long term synaptic depression (GO:0060292)2.99425417
95synapse assembly (GO:0007416)2.98541148
96synaptic transmission (GO:0007268)2.96741734
97regulation of dendritic spine morphogenesis (GO:0061001)2.94675054
98regulation of membrane repolarization (GO:0060306)2.92382205
99negative regulation of cytosolic calcium ion concentration (GO:0051481)2.92107897
100activation of protein kinase A activity (GO:0034199)2.91627983
101cell differentiation in hindbrain (GO:0021533)2.90399881
102postsynaptic membrane organization (GO:0001941)2.90233616
103presynaptic membrane assembly (GO:0097105)2.89618663
104neuromuscular synaptic transmission (GO:0007274)2.86537448
105neuromuscular process controlling posture (GO:0050884)2.86516049
106action potential (GO:0001508)2.85760755
107cell migration in hindbrain (GO:0021535)2.85362988
108potassium ion import (GO:0010107)2.85358357
109chemosensory behavior (GO:0007635)2.85296963
110learning (GO:0007612)2.85255624
111neuromuscular process controlling balance (GO:0050885)2.84748540
112positive regulation of dendritic spine morphogenesis (GO:0061003)2.84350766
113microtubule bundle formation (GO:0001578)2.82981769
114membrane repolarization (GO:0086009)2.82633547
115regulation of microtubule-based movement (GO:0060632)2.82448842
116cochlea development (GO:0090102)2.81080027
117regulation of neurotransmitter uptake (GO:0051580)2.80964023
118detection of calcium ion (GO:0005513)2.80814066
119cilium organization (GO:0044782)2.80566500
120regulation of skeletal muscle contraction (GO:0014819)2.80397361
121positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.78561954
122regulation of voltage-gated calcium channel activity (GO:1901385)2.78275244
123negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.77753341
124positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.77294503
125striatum development (GO:0021756)2.76961830
126water-soluble vitamin biosynthetic process (GO:0042364)2.75383816
127pharyngeal system development (GO:0060037)2.71975244
128mechanosensory behavior (GO:0007638)2.71834378
129protein localization to cilium (GO:0061512)2.71011097
130regulation of action potential (GO:0098900)2.68762488
131intraciliary transport (GO:0042073)2.68400099
132serotonin metabolic process (GO:0042428)2.68111377
133cilium assembly (GO:0042384)2.67576855
134negative regulation of response to food (GO:0032096)2.61185144
135negative regulation of appetite (GO:0032099)2.61185144
136regulation of collateral sprouting (GO:0048670)2.58827999
137detection of light stimulus involved in sensory perception (GO:0050962)2.57728017
138detection of light stimulus involved in visual perception (GO:0050908)2.57728017
139primary amino compound metabolic process (GO:1901160)2.57201216
140mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.56302233
141mitochondrial respiratory chain complex I assembly (GO:0032981)2.56302233
142NADH dehydrogenase complex assembly (GO:0010257)2.56302233
143lateral sprouting from an epithelium (GO:0060601)2.53434913
144somite development (GO:0061053)2.51637680
145response to auditory stimulus (GO:0010996)2.49490393
146regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.48330679
147limb development (GO:0060173)2.47803884
148appendage development (GO:0048736)2.47803884
149positive regulation of fatty acid oxidation (GO:0046321)2.47534949
150nonmotile primary cilium assembly (GO:0035058)2.45490548
151regulation of potassium ion transmembrane transport (GO:1901379)2.42598538
152behavioral response to ethanol (GO:0048149)2.41871137
153regulation of female receptivity (GO:0045924)2.39819076
154left/right axis specification (GO:0070986)2.38352312
155cornea development in camera-type eye (GO:0061303)2.37385020
156multicellular organismal signaling (GO:0035637)2.35773973
157cilium morphogenesis (GO:0060271)2.34835780
158left/right pattern formation (GO:0060972)2.34227721
159peristalsis (GO:0030432)2.33783010
160reflex (GO:0060004)2.32915824
161positive regulation of cardiac muscle cell differentiation (GO:2000727)2.31945163
162neurofilament cytoskeleton organization (GO:0060052)2.31589016
163regulation of mesoderm development (GO:2000380)2.31546310
164detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.29711902
165negative regulation of transcription regulatory region DNA binding (GO:2000678)2.28136085
166synaptic transmission, cholinergic (GO:0007271)2.27798077
167cellular component assembly involved in morphogenesis (GO:0010927)2.27121981
168retinal cone cell development (GO:0046549)2.26943827
169calcium ion import (GO:0070509)2.25682912
170positive regulation of oligodendrocyte differentiation (GO:0048714)2.25386963
171positive regulation of meiosis (GO:0045836)2.24979287
172regulation of cell communication by electrical coupling (GO:0010649)2.24778587
173protein complex biogenesis (GO:0070271)2.23325609
174spinal cord motor neuron differentiation (GO:0021522)2.22095758
175negative regulation of astrocyte differentiation (GO:0048712)2.22080339
176cellular response to ATP (GO:0071318)2.22023677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.72632590
2GBX2_23144817_ChIP-Seq_PC3_Human3.78273001
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94449656
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92573240
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84723047
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56363195
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56363195
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51669513
9REST_21632747_ChIP-Seq_MESCs_Mouse2.49018631
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45015592
11DROSHA_22980978_ChIP-Seq_HELA_Human2.44677737
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.39528429
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39005139
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36007309
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34451512
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32227899
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.26467225
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23230638
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.15544877
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10953027
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.10620805
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.05494130
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03887335
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92999206
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91329893
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.90907166
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90104066
28* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84625167
29SMAD4_21799915_ChIP-Seq_A2780_Human1.81419136
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78376940
31AR_21572438_ChIP-Seq_LNCaP_Human1.74553381
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65404252
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63328719
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62058850
35TAF15_26573619_Chip-Seq_HEK293_Human1.59307593
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59186021
37EWS_26573619_Chip-Seq_HEK293_Human1.57866641
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54884673
39ZNF274_21170338_ChIP-Seq_K562_Hela1.52058185
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51655149
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49916316
42P300_19829295_ChIP-Seq_ESCs_Human1.47721006
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47145315
44* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45609664
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44506215
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.44219008
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41636277
48AR_25329375_ChIP-Seq_VCAP_Human1.39830770
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39462491
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.38264533
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.38197993
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37296612
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37123340
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.36509715
55CBP_20019798_ChIP-Seq_JUKART_Human1.33295222
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33295222
57* STAT3_23295773_ChIP-Seq_U87_Human1.32028587
58* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30793652
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30737533
60* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29610240
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28697033
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28401736
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27719623
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27605971
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.27443046
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.27358623
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.26785864
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26640119
69AHR_22903824_ChIP-Seq_MCF-7_Human1.26097548
70FUS_26573619_Chip-Seq_HEK293_Human1.24404995
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24304491
72AR_19668381_ChIP-Seq_PC3_Human1.22767226
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.21596487
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.19621185
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18302443
76* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16354623
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.15864208
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15607809
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15228291
80* TCF4_23295773_ChIP-Seq_U87_Human1.14869657
81RNF2_27304074_Chip-Seq_NSC_Mouse1.14107828
82* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12513688
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11033818
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.10504231
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10151155
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09914602
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.08494785
88IGF1R_20145208_ChIP-Seq_DFB_Human1.07589789
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07394116
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06222264
91TAL1_26923725_Chip-Seq_HPCs_Mouse1.05941100
92SMAD3_21741376_ChIP-Seq_HESCs_Human1.05588318
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04250769
94IRF1_19129219_ChIP-ChIP_H3396_Human1.03937643
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03253637
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02284599
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.02040349
98RUNX2_22187159_ChIP-Seq_PCA_Human1.01215115
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01113820
100* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00787369
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00179009
102PRDM14_20953172_ChIP-Seq_ESCs_Human0.99510423
103* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98595321
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.98513632
105* P53_22387025_ChIP-Seq_ESCs_Mouse0.97959720
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97187970
107NCOR_22424771_ChIP-Seq_293T_Human0.97143755
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97074736
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97074736
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97000773
111ER_23166858_ChIP-Seq_MCF-7_Human0.96883647
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96265389
113* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96251984
114BCAT_22108803_ChIP-Seq_LS180_Human0.96193103
115* NANOG_18555785_Chip-Seq_ESCs_Mouse0.92792816
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.91002228
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89713081
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89067257
119TP53_18474530_ChIP-ChIP_U2OS_Human0.86380348
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85303421
121JUN_21703547_ChIP-Seq_K562_Human0.83515847
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82776120
123VDR_22108803_ChIP-Seq_LS180_Human0.82509501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.45766748
2MP0003880_abnormal_central_pattern4.28938601
3MP0003635_abnormal_synaptic_transmissio3.75080165
4MP0004270_analgesia3.45495524
5MP0009745_abnormal_behavioral_response3.17906732
6MP0009046_muscle_twitch3.06057496
7MP0002063_abnormal_learning/memory/cond3.00892572
8MP0002064_seizures2.95351693
9MP0002653_abnormal_ependyma_morphology2.76783555
10MP0001968_abnormal_touch/_nociception2.70780284
11MP0002734_abnormal_mechanical_nocicepti2.54574750
12MP0002572_abnormal_emotion/affect_behav2.52835167
13MP0002272_abnormal_nervous_system2.50230358
14MP0005423_abnormal_somatic_nervous2.50066062
15MP0001486_abnormal_startle_reflex2.41924744
16MP0002735_abnormal_chemical_nociception2.18304482
17MP0001501_abnormal_sleep_pattern2.16764198
18MP0001440_abnormal_grooming_behavior2.15182380
19MP0002067_abnormal_sensory_capabilities2.11467821
20MP0002736_abnormal_nociception_after2.10363034
21MP0001984_abnormal_olfaction2.09135077
22MP0005551_abnormal_eye_electrophysiolog1.90725406
23MP0002184_abnormal_innervation1.88794473
24MP0002160_abnormal_reproductive_system1.88105707
25MP0002733_abnormal_thermal_nociception1.84395693
26MP0008569_lethality_at_weaning1.83180390
27MP0004145_abnormal_muscle_electrophysio1.78422469
28MP0002822_catalepsy1.77299892
29MP0001970_abnormal_pain_threshold1.74912163
30MP0003879_abnormal_hair_cell1.73347113
31MP0000778_abnormal_nervous_system1.70722901
32MP0002557_abnormal_social/conspecific_i1.68068226
33MP0004885_abnormal_endolymph1.65781467
34MP0000049_abnormal_middle_ear1.62180856
35MP0004130_abnormal_muscle_cell1.60894030
36MP0003787_abnormal_imprinting1.59341335
37MP0001502_abnormal_circadian_rhythm1.59250920
38MP0002909_abnormal_adrenal_gland1.58120920
39MP0004924_abnormal_behavior1.57499870
40MP0005386_behavior/neurological_phenoty1.57499870
41MP0001188_hyperpigmentation1.54675927
42MP0004858_abnormal_nervous_system1.53934658
43MP0004043_abnormal_pH_regulation1.50207329
44MP0003329_amyloid_beta_deposits1.45740037
45MP0006276_abnormal_autonomic_nervous1.44951608
46MP0002882_abnormal_neuron_morphology1.43592565
47MP0004142_abnormal_muscle_tone1.40903383
48MP0005646_abnormal_pituitary_gland1.40782813
49MP0004811_abnormal_neuron_physiology1.39757952
50MP0000955_abnormal_spinal_cord1.37052675
51MP0004133_heterotaxia1.36977727
52MP0009780_abnormal_chondrocyte_physiolo1.36041098
53MP0000751_myopathy1.33333566
54MP0002066_abnormal_motor_capabilities/c1.32743506
55MP0005670_abnormal_white_adipose1.32290944
56MP0008877_abnormal_DNA_methylation1.32063412
57MP0002102_abnormal_ear_morphology1.30518536
58MP0010386_abnormal_urinary_bladder1.22177245
59MP0006072_abnormal_retinal_apoptosis1.19503173
60MP0002638_abnormal_pupillary_reflex1.19038854
61MP0008789_abnormal_olfactory_epithelium1.18748769
62MP0003119_abnormal_digestive_system1.18617003
63MP0005389_reproductive_system_phenotype1.16474618
64MP0004215_abnormal_myocardial_fiber1.16435914
65MP0004233_abnormal_muscle_weight1.15008913
66MP0002229_neurodegeneration1.13825398
67MP0008961_abnormal_basal_metabolism1.12774491
68MP0004742_abnormal_vestibular_system1.10643325
69MP0003633_abnormal_nervous_system1.09523022
70MP0008875_abnormal_xenobiotic_pharmacok1.08483040
71MP0003136_yellow_coat_color1.06975349
72MP0009379_abnormal_foot_pigmentation1.06644983
73MP0002090_abnormal_vision1.04967256
74MP0002152_abnormal_brain_morphology1.04360467
75MP0002837_dystrophic_cardiac_calcinosis1.04266092
76MP0003937_abnormal_limbs/digits/tail_de1.03241631
77MP0005499_abnormal_olfactory_system1.03187542
78MP0005394_taste/olfaction_phenotype1.03187542
79MP0001485_abnormal_pinna_reflex1.01885770
80MP0001905_abnormal_dopamine_level1.00655032
81MP0002752_abnormal_somatic_nervous1.00381350
82MP0003122_maternal_imprinting0.99834609
83MP0000383_abnormal_hair_follicle0.99140055
84MP0000749_muscle_degeneration0.97480507
85MP0001963_abnormal_hearing_physiology0.94862764
86MP0003631_nervous_system_phenotype0.94795850
87MP0006292_abnormal_olfactory_placode0.94491621
88MP0004085_abnormal_heartbeat0.94002218
89MP0002069_abnormal_eating/drinking_beha0.93934677
90MP0005171_absent_coat_pigmentation0.90127718
91MP0005645_abnormal_hypothalamus_physiol0.89596907
92MP0001177_atelectasis0.89306643
93MP0008775_abnormal_heart_ventricle0.88368315
94MP0001529_abnormal_vocalization0.86287614
95MP0003646_muscle_fatigue0.85348137
96MP0005253_abnormal_eye_physiology0.84886725
97MP0004484_altered_response_of0.83437534
98MP0003283_abnormal_digestive_organ0.83261535
99MP0003890_abnormal_embryonic-extraembry0.82685611
100MP0009250_abnormal_appendicular_skeleto0.82503930
101MP0004147_increased_porphyrin_level0.82417509
102MP0001765_abnormal_ion_homeostasis0.81688822
103MP0000631_abnormal_neuroendocrine_gland0.81210520
104MP0002876_abnormal_thyroid_physiology0.81171481
105MP0003938_abnormal_ear_development0.80396754
106MP0003137_abnormal_impulse_conducting0.79323461
107MP0002277_abnormal_respiratory_mucosa0.79307570
108MP0000013_abnormal_adipose_tissue0.77517285
109MP0003011_delayed_dark_adaptation0.77425905
110MP0005187_abnormal_penis_morphology0.76562416
111MP0005367_renal/urinary_system_phenotyp0.74940936
112MP0000516_abnormal_urinary_system0.74940936
113MP0008872_abnormal_physiological_respon0.74091399
114MP0001664_abnormal_digestion0.73285606
115MP0000569_abnormal_digit_pigmentation0.71768047
116MP0005377_hearing/vestibular/ear_phenot0.70864780
117MP0003878_abnormal_ear_physiology0.70864780
118MP0002234_abnormal_pharynx_morphology0.70677248
119MP0003183_abnormal_peptide_metabolism0.69118832
120MP0005535_abnormal_body_temperature0.68339528
121MP0003634_abnormal_glial_cell0.68095227
122MP0000026_abnormal_inner_ear0.66994385
123MP0003632_abnormal_nervous_system0.66785056
124MP0001299_abnormal_eye_distance/0.65858118
125MP0005620_abnormal_muscle_contractility0.63306310
126MP0000747_muscle_weakness0.61677406
127MP0005195_abnormal_posterior_eye0.60129403

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.39469025
2Absent/shortened dynein arms (HP:0200106)5.61766061
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.61766061
4Focal seizures (HP:0007359)5.25526042
5Abnormal respiratory motile cilium morphology (HP:0005938)5.24660626
6Abnormal respiratory epithelium morphology (HP:0012253)5.24660626
7Abnormal ciliary motility (HP:0012262)5.24378001
8Febrile seizures (HP:0002373)5.18621983
9Myokymia (HP:0002411)5.15714173
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.99510685
11Abnormal respiratory motile cilium physiology (HP:0012261)4.97537964
12Progressive cerebellar ataxia (HP:0002073)4.93720572
13Epileptic encephalopathy (HP:0200134)4.75459159
14Visual hallucinations (HP:0002367)4.53170997
15Atonic seizures (HP:0010819)4.47337753
16Absence seizures (HP:0002121)4.30659889
17Rhinitis (HP:0012384)4.25306502
18Dialeptic seizures (HP:0011146)3.99606345
19Pancreatic fibrosis (HP:0100732)3.88701421
20True hermaphroditism (HP:0010459)3.72438232
21Action tremor (HP:0002345)3.71029006
22Generalized tonic-clonic seizures (HP:0002069)3.52948914
23Pancreatic cysts (HP:0001737)3.52269744
24Congenital stationary night blindness (HP:0007642)3.51913833
25Broad-based gait (HP:0002136)3.49870981
26Gaze-evoked nystagmus (HP:0000640)3.42152621
27Nephronophthisis (HP:0000090)3.31110442
28Hyperventilation (HP:0002883)3.19963308
29Genetic anticipation (HP:0003743)3.17726514
30Abnormality of midbrain morphology (HP:0002418)3.15886074
31Molar tooth sign on MRI (HP:0002419)3.15886074
32Dysdiadochokinesis (HP:0002075)3.09316857
33Chronic bronchitis (HP:0004469)2.93751374
34Increased circulating renin level (HP:0000848)2.92022413
35Truncal ataxia (HP:0002078)2.91470645
36Short 1st metacarpal (HP:0010034)2.82210245
37Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.82210245
38Abnormal eating behavior (HP:0100738)2.76536843
39Dysmetria (HP:0001310)2.72145132
40Supranuclear gaze palsy (HP:0000605)2.71545855
41Abnormality of macular pigmentation (HP:0008002)2.70931851
42Ventricular fibrillation (HP:0001663)2.70338030
43Excessive salivation (HP:0003781)2.69725544
44Drooling (HP:0002307)2.69725544
45Central scotoma (HP:0000603)2.68211097
46Abnormality of the renal medulla (HP:0100957)2.65943333
47Bronchiectasis (HP:0002110)2.60933227
48Depression (HP:0000716)2.58308010
49Dysmetric saccades (HP:0000641)2.57481227
50Anxiety (HP:0000739)2.54334928
51Mutism (HP:0002300)2.52563108
52Poor eye contact (HP:0000817)2.52280868
53Cystic liver disease (HP:0006706)2.51095217
54Impaired social interactions (HP:0000735)2.49195966
55Abnormal social behavior (HP:0012433)2.49195966
56Impaired smooth pursuit (HP:0007772)2.48363556
57Scanning speech (HP:0002168)2.47823191
58Amblyopia (HP:0000646)2.46885401
59Medial flaring of the eyebrow (HP:0010747)2.44909740
60Hemiparesis (HP:0001269)2.44523480
61Abnormality of the 1st metacarpal (HP:0010009)2.40628892
62Blue irides (HP:0000635)2.37607449
63Urinary bladder sphincter dysfunction (HP:0002839)2.36333895
64Ankle clonus (HP:0011448)2.36265061
65Hyperactive renin-angiotensin system (HP:0000841)2.35273008
66Epileptiform EEG discharges (HP:0011182)2.34980798
67Stenosis of the external auditory canal (HP:0000402)2.31609790
68Pendular nystagmus (HP:0012043)2.31115677
69Postural instability (HP:0002172)2.29939173
70Impaired vibration sensation in the lower limbs (HP:0002166)2.27680365
71Pheochromocytoma (HP:0002666)2.25436440
72Furrowed tongue (HP:0000221)2.22575637
73Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21807925
74Hemiplegia (HP:0002301)2.20838523
75Fetal akinesia sequence (HP:0001989)2.20330528
76Muscle fiber inclusion bodies (HP:0100299)2.18746973
77Chronic hepatic failure (HP:0100626)2.18530852
78Type II lissencephaly (HP:0007260)2.17506698
79Abnormality of ocular smooth pursuit (HP:0000617)2.17388559
80Short hallux (HP:0010109)2.17072742
81Sclerocornea (HP:0000647)2.15406463
82EEG with generalized epileptiform discharges (HP:0011198)2.13983949
83Absent speech (HP:0001344)2.13604501
84Stereotypic behavior (HP:0000733)2.12004619
85Abnormality of the renal cortex (HP:0011035)2.11988665
86Abnormal rod and cone electroretinograms (HP:0008323)2.11154561
87Hyperaldosteronism (HP:0000859)2.10539107
88Postaxial foot polydactyly (HP:0001830)2.10036419
89Polyphagia (HP:0002591)2.09613139
90Abolished electroretinogram (ERG) (HP:0000550)2.08791568
91Abnormality of the lower motor neuron (HP:0002366)2.08308408
92Anencephaly (HP:0002323)2.07738134
93Status epilepticus (HP:0002133)2.06959962
94Prolonged QT interval (HP:0001657)2.06332512
95Metabolic alkalosis (HP:0200114)2.06005417
96Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.05553954
97Syncope (HP:0001279)2.05124581
98Gout (HP:0001997)2.04774956
99Abnormality of binocular vision (HP:0011514)2.04571725
100Diplopia (HP:0000651)2.04571725
101Agitation (HP:0000713)2.03730561
102Male pseudohermaphroditism (HP:0000037)2.02086596
103Aplasia/Hypoplasia of the hallux (HP:0008362)2.01587433
104Muscle hypertrophy of the lower extremities (HP:0008968)1.99634171
105Abnormal EKG (HP:0003115)1.99119489
106Nemaline bodies (HP:0003798)1.98800813
107Congenital sensorineural hearing impairment (HP:0008527)1.97756971
108Abnormality of the middle phalanges of the toes (HP:0010183)1.97381424
109Hypomagnesemia (HP:0002917)1.96894520
110Bradykinesia (HP:0002067)1.96850699
111Congenital hepatic fibrosis (HP:0002612)1.94831060
112Abnormality of the renal collecting system (HP:0004742)1.94351074
113Abnormality of renin-angiotensin system (HP:0000847)1.93592675
114Incomplete penetrance (HP:0003829)1.93431544
115Occipital encephalocele (HP:0002085)1.92859992
116Nephrogenic diabetes insipidus (HP:0009806)1.91677611
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.90739059
118Infertility (HP:0000789)1.90568009
119Gait imbalance (HP:0002141)1.89210796
120Decreased circulating renin level (HP:0003351)1.88749654
121Chorioretinal atrophy (HP:0000533)1.88581643
122Hypsarrhythmia (HP:0002521)1.87076911
123Genital tract atresia (HP:0001827)1.87071175
124Neuroendocrine neoplasm (HP:0100634)1.86629098
125Hyperkalemia (HP:0002153)1.86544647
126Severe visual impairment (HP:0001141)1.86352718
127Calf muscle hypertrophy (HP:0008981)1.85553362
128Vaginal atresia (HP:0000148)1.85225756
129Symphalangism affecting the phalanges of the hand (HP:0009773)1.84601582
130Protruding tongue (HP:0010808)1.84034975
131Tubular atrophy (HP:0000092)1.83912562
132Aplasia/Hypoplasia of the spleen (HP:0010451)1.83850018
133Intention tremor (HP:0002080)1.83558160
134Urinary urgency (HP:0000012)1.80073639
135Short phalanx of the thumb (HP:0009660)1.80068127
136Morphological abnormality of the middle ear (HP:0008609)1.79567893
137Limb dystonia (HP:0002451)1.79413732
138Ectopic kidney (HP:0000086)1.79331257
139Asplenia (HP:0001746)1.79281229
140Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79136541
141Polydipsia (HP:0001959)1.78606821
142Abnormal drinking behavior (HP:0030082)1.78606821
143Bundle branch block (HP:0011710)1.78199859
144Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77316034
145Abnormality of salivation (HP:0100755)1.76532272
146Spastic gait (HP:0002064)1.76133114
147Exercise-induced myalgia (HP:0003738)1.75285657
148Retinal dysplasia (HP:0007973)1.72166775
149Postaxial hand polydactyly (HP:0001162)1.69997623
150Acute necrotizing encephalopathy (HP:0006965)1.69474641
151Confusion (HP:0001289)1.67097026
152Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67054604
153Abnormality of alanine metabolism (HP:0010916)1.67054604
154Hyperalaninemia (HP:0003348)1.67054604
155Hypoventilation (HP:0002791)1.67033813
156Progressive inability to walk (HP:0002505)1.66866939
157Inability to walk (HP:0002540)1.66383115
158Bony spicule pigmentary retinopathy (HP:0007737)1.65503731
159Abnormality of magnesium homeostasis (HP:0004921)1.65434521
160Nasal polyposis (HP:0100582)1.65203329
161Methylmalonic acidemia (HP:0002912)1.64782029
162Decreased central vision (HP:0007663)1.64349619
163Gait ataxia (HP:0002066)1.64302067
164Exotropia (HP:0000577)1.64067512
165Scotoma (HP:0000575)1.63849030
166Aplasia/Hypoplasia of the tibia (HP:0005772)1.63794228
167Keratoconus (HP:0000563)1.63566453
168Increased corneal curvature (HP:0100692)1.63566453
169Torticollis (HP:0000473)1.63318962
170Psychosis (HP:0000709)1.62699180
171Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.61291300
172Impaired vibratory sensation (HP:0002495)1.60115880
173Insidious onset (HP:0003587)1.59229605
174Termporal pattern (HP:0011008)1.59229605
175Specific learning disability (HP:0001328)1.58492166
176Synostosis of carpal bones (HP:0005048)1.57827813
177Myotonia (HP:0002486)1.57803903
178Cutaneous finger syndactyly (HP:0010554)1.57776108
179Congenital primary aphakia (HP:0007707)1.57171194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.51156581
2FRK3.78808564
3EPHA43.62371660
4OBSCN3.17164956
5MAP3K93.15437634
6MAP3K43.04699360
7MARK12.81123102
8MAP2K72.53816155
9MINK12.52719838
10ADRBK22.41435862
11MAPK152.36096441
12BMPR1B2.33870271
13GRK12.31221716
14PAK62.27594546
15DAPK22.16170481
16TNIK2.14593583
17CASK2.09297426
18AKT31.84192863
19MAP2K41.76969303
20STK381.75733791
21NTRK21.68275902
22WNK31.62871293
23OXSR11.60539595
24PNCK1.57683173
25ACVR1B1.53968738
26NEK11.52240345
27RIPK41.49888942
28MUSK1.47106884
29KSR11.45380727
30CAMKK11.44979922
31TLK11.44473703
32PLK21.44389283
33MAP3K121.41420638
34CAMKK21.38246878
35KSR21.37881271
36PHKG11.37721919
37PHKG21.37721919
38CDK51.37221058
39MAP4K21.34980589
40PRKCG1.33764756
41NTRK11.32714396
42MAPK131.31184869
43GRK51.30555334
44PRPF4B1.28816771
45NME11.26372844
46PINK11.25498995
47DAPK11.23734999
48SGK4941.23074862
49SGK2231.23074862
50SGK21.15625022
51WNK41.14683115
52SIK21.14374114
53INSRR1.13886024
54DYRK21.08082382
55CSNK1G11.07123243
56WNK11.04882264
57CAMK2B1.04793766
58CAMK2A1.02419124
59PRKD31.02132508
60CSNK1G31.01581684
61ZAK1.00834581
62NUAK10.94441327
63ARAF0.93070201
64LATS20.92851380
65MARK20.91647965
66LMTK20.91052412
67MAP3K20.89014934
68UHMK10.87374096
69CSNK1G20.86593506
70SGK30.86107339
71DYRK1A0.85858860
72ADRBK10.84932594
73FER0.84800280
74CSNK1A1L0.83624011
75CDK190.82425850
76CAMK10.81011279
77MAP2K10.80135987
78PAK30.79942619
79CAMK2D0.78673712
80FES0.76643955
81SGK10.76506404
82STK390.72823405
83TIE10.72167061
84CCNB10.71369065
85PRKCE0.71111612
86STK110.69896014
87NEK60.69441005
88PTK2B0.69351248
89CDK180.68388307
90CDK140.66986988
91CDK150.66433783
92MAP3K130.65979129
93PKN10.65724976
94BMPR20.65381498
95TAOK30.65363822
96MKNK20.64334949
97CSNK1A10.64300148
98TAOK10.62703691
99CAMK2G0.62358768
100MST40.61270099
101MAPKAPK30.61072829
102MAP3K70.60604389
103BCKDK0.60547780
104CDK11A0.57828024
105CDC42BPA0.57139383
106ERBB20.54359432
107STK160.54214267
108PRKCH0.53017446
109MAPKAPK50.52438539
110CSNK1D0.52119498
111RPS6KA30.51404426
112CSNK1E0.49334598
113RET0.49320352
114CDK30.48721519
115RIPK10.47220286
116PRKCA0.46656057
117PLK10.46037012
118PRKCZ0.45488654
119CAMK1G0.43076846
120RPS6KB10.42483944
121SIK30.42327649
122CDC70.41990801
123TYRO30.41460120
124PRKAA10.41410718
125MAPK100.40935290
126FGFR20.40846815
127PDPK10.40454083
128RAF10.40178849
129PDK10.39896615
130PRKACA0.39472631
131TGFBR10.39324722
132PDK40.38756392
133PDK30.38756392
134MAPK120.38655952
135AURKA0.38454200
136BRAF0.37804730
137ERBB30.37390248
138TAOK20.37374579
139ROCK20.37251775
140MAP3K60.36829339
141PRKG10.35982478
142PRKAA20.35791398
143MAP2K60.35709194
144PRKDC0.35699038

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.15299656
2Synaptic vesicle cycle_Homo sapiens_hsa047213.26120077
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.79370235
4GABAergic synapse_Homo sapiens_hsa047272.79123609
5Circadian entrainment_Homo sapiens_hsa047132.71581239
6Morphine addiction_Homo sapiens_hsa050322.53913846
7Glutamatergic synapse_Homo sapiens_hsa047242.51577298
8Olfactory transduction_Homo sapiens_hsa047402.41770204
9Long-term potentiation_Homo sapiens_hsa047202.41727040
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35337921
11Amphetamine addiction_Homo sapiens_hsa050312.22419288
12Salivary secretion_Homo sapiens_hsa049702.16332685
13Taste transduction_Homo sapiens_hsa047422.07382267
14Insulin secretion_Homo sapiens_hsa049112.04560315
15Dopaminergic synapse_Homo sapiens_hsa047281.95549038
16Linoleic acid metabolism_Homo sapiens_hsa005911.90594733
17Collecting duct acid secretion_Homo sapiens_hsa049661.84162091
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.81690183
19Gastric acid secretion_Homo sapiens_hsa049711.81626452
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.78000934
21Nitrogen metabolism_Homo sapiens_hsa009101.77561589
22Cholinergic synapse_Homo sapiens_hsa047251.76174730
23Serotonergic synapse_Homo sapiens_hsa047261.70577484
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.68912753
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68093204
26Long-term depression_Homo sapiens_hsa047301.65140964
27Renin secretion_Homo sapiens_hsa049241.63672357
28Oxytocin signaling pathway_Homo sapiens_hsa049211.62492762
29Phototransduction_Homo sapiens_hsa047441.60778977
30Calcium signaling pathway_Homo sapiens_hsa040201.59875720
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59214779
32Huntingtons disease_Homo sapiens_hsa050161.58124725
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55650508
34Chemical carcinogenesis_Homo sapiens_hsa052041.55490718
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55394107
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51716757
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.49958797
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44259601
39Parkinsons disease_Homo sapiens_hsa050121.38105648
40Cocaine addiction_Homo sapiens_hsa050301.34986388
41GnRH signaling pathway_Homo sapiens_hsa049121.33551228
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33310251
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29828731
44cAMP signaling pathway_Homo sapiens_hsa040241.27786237
45Circadian rhythm_Homo sapiens_hsa047101.27760138
46Cardiac muscle contraction_Homo sapiens_hsa042601.22848732
47Gap junction_Homo sapiens_hsa045401.19804390
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16970893
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14282473
50Type II diabetes mellitus_Homo sapiens_hsa049301.13995406
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12969455
52Caffeine metabolism_Homo sapiens_hsa002321.12838499
53beta-Alanine metabolism_Homo sapiens_hsa004101.10942208
54Retinol metabolism_Homo sapiens_hsa008301.10166391
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06914964
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06840911
57Ether lipid metabolism_Homo sapiens_hsa005651.00531626
58Tryptophan metabolism_Homo sapiens_hsa003800.98762831
59Sulfur metabolism_Homo sapiens_hsa009200.97543930
60Vibrio cholerae infection_Homo sapiens_hsa051100.97396577
61Axon guidance_Homo sapiens_hsa043600.96985698
62Histidine metabolism_Homo sapiens_hsa003400.96482024
63Estrogen signaling pathway_Homo sapiens_hsa049150.96028416
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.94331360
65Pancreatic secretion_Homo sapiens_hsa049720.92316826
66Dilated cardiomyopathy_Homo sapiens_hsa054140.91375821
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.90937864
68Propanoate metabolism_Homo sapiens_hsa006400.87345673
69ErbB signaling pathway_Homo sapiens_hsa040120.87009133
70Glioma_Homo sapiens_hsa052140.86374759
71Thyroid hormone synthesis_Homo sapiens_hsa049180.85364136
72ABC transporters_Homo sapiens_hsa020100.83318608
73Melanogenesis_Homo sapiens_hsa049160.83235205
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83123075
75Selenocompound metabolism_Homo sapiens_hsa004500.82805133
76Mineral absorption_Homo sapiens_hsa049780.82089568
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82080987
78Basal transcription factors_Homo sapiens_hsa030220.81931737
79Fanconi anemia pathway_Homo sapiens_hsa034600.80927126
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80356191
81Choline metabolism in cancer_Homo sapiens_hsa052310.78325815
82RNA degradation_Homo sapiens_hsa030180.78239603
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77792558
84Hedgehog signaling pathway_Homo sapiens_hsa043400.77611229
85Inositol phosphate metabolism_Homo sapiens_hsa005620.76566495
86Peroxisome_Homo sapiens_hsa041460.74742739
87Basal cell carcinoma_Homo sapiens_hsa052170.70606074
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69967811
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.68791858
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68475853
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68375520
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67618620
93Dorso-ventral axis formation_Homo sapiens_hsa043200.66147057
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66120210
95Oocyte meiosis_Homo sapiens_hsa041140.65746924
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65616414
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65075533
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63005333
99Arginine and proline metabolism_Homo sapiens_hsa003300.61224483
100RNA polymerase_Homo sapiens_hsa030200.60948517
101MAPK signaling pathway_Homo sapiens_hsa040100.60782643
102Sulfur relay system_Homo sapiens_hsa041220.59625552
103Bile secretion_Homo sapiens_hsa049760.57817783
104Glycerolipid metabolism_Homo sapiens_hsa005610.57569979
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56948156
106Renin-angiotensin system_Homo sapiens_hsa046140.56737693
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54466246
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.53078492
109Glucagon signaling pathway_Homo sapiens_hsa049220.51906974
110Hippo signaling pathway_Homo sapiens_hsa043900.51611670
111Homologous recombination_Homo sapiens_hsa034400.49951686
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49819823
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48013200
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47333314
115mTOR signaling pathway_Homo sapiens_hsa041500.46014713
116Ras signaling pathway_Homo sapiens_hsa040140.44939504
117Rap1 signaling pathway_Homo sapiens_hsa040150.44468078
118Wnt signaling pathway_Homo sapiens_hsa043100.42776003
119Purine metabolism_Homo sapiens_hsa002300.42425942
120Starch and sucrose metabolism_Homo sapiens_hsa005000.42108734
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41630029
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41363165
123Alzheimers disease_Homo sapiens_hsa050100.41089993
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40523046
125Endometrial cancer_Homo sapiens_hsa052130.38388311
126Insulin signaling pathway_Homo sapiens_hsa049100.37331574
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36304834
128Ovarian steroidogenesis_Homo sapiens_hsa049130.35190584
129Butanoate metabolism_Homo sapiens_hsa006500.34974769
130VEGF signaling pathway_Homo sapiens_hsa043700.34505767
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.34310175
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33198101
133Renal cell carcinoma_Homo sapiens_hsa052110.31894513
134Tight junction_Homo sapiens_hsa045300.31183305
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30642158
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28800796
137Endocytosis_Homo sapiens_hsa041440.28626016
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.28460177
139Alcoholism_Homo sapiens_hsa050340.28320368
140Oxidative phosphorylation_Homo sapiens_hsa001900.27303309
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.26550937
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26094888
143Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25385032
144Regulation of autophagy_Homo sapiens_hsa041400.25241391
145Fructose and mannose metabolism_Homo sapiens_hsa000510.25194898

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