OSBPL7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding the same isoform have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)9.00494025
2doxorubicin metabolic process (GO:0044598)9.00494025
3daunorubicin metabolic process (GO:0044597)9.00494025
4maintenance of protein location in nucleus (GO:0051457)6.14253077
5regulation of nuclear cell cycle DNA replication (GO:0033262)5.91022183
6aminoglycoside antibiotic metabolic process (GO:0030647)5.49291228
7regulation of mammary gland epithelial cell proliferation (GO:0033599)5.35956364
8regulation of telomere maintenance via telomerase (GO:0032210)5.33450457
9interferon-gamma production (GO:0032609)5.31871904
10mannose metabolic process (GO:0006013)5.17834594
11negative regulation of erythrocyte differentiation (GO:0045647)5.15519751
12regulation of response to osmotic stress (GO:0047484)5.12140672
13histone H4-K12 acetylation (GO:0043983)5.06126820
14regulation of MHC class I biosynthetic process (GO:0045343)5.02826074
15somite rostral/caudal axis specification (GO:0032525)5.02665228
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.01332528
17negative regulation of telomerase activity (GO:0051974)4.94180936
18negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.86610268
19antigen processing and presentation of endogenous antigen (GO:0019883)4.84425726
20histone H4-K5 acetylation (GO:0043981)4.83975587
21histone H4-K8 acetylation (GO:0043982)4.83975587
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.80345871
23negative regulation of cell killing (GO:0031342)4.80345871
24protein localization to kinetochore (GO:0034501)4.80325123
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.78352603
26positive regulation of gamma-delta T cell activation (GO:0046645)4.69015361
27negative regulation of epidermis development (GO:0045683)4.68202535
28negative regulation of cell cycle G2/M phase transition (GO:1902750)4.54154118
29negative regulation of telomere maintenance (GO:0032205)4.39959834
30positive thymic T cell selection (GO:0045059)4.39398619
31rRNA transcription (GO:0009303)4.38457297
32rRNA methylation (GO:0031167)4.36804320
33positive regulation of DNA-dependent DNA replication (GO:2000105)4.34038876
34thymic T cell selection (GO:0045061)4.30976178
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.28069877
36rRNA modification (GO:0000154)4.17221888
37muscle organ morphogenesis (GO:0048644)4.02807005
38negative thymic T cell selection (GO:0045060)4.01148646
39negative regulation of epidermal cell differentiation (GO:0045605)3.98601495
40positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.89131827
41regulation of gamma-delta T cell differentiation (GO:0045586)3.88509404
42mitotic sister chromatid segregation (GO:0000070)3.84424872
43branching involved in mammary gland duct morphogenesis (GO:0060444)3.84191028
44negative T cell selection (GO:0043383)3.82727526
45negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.79123612
46nucleoside transmembrane transport (GO:1901642)3.78386956
47regulation of translation in response to stress (GO:0043555)3.78024310
48regulation of gamma-delta T cell activation (GO:0046643)3.75988099
49DNA replication checkpoint (GO:0000076)3.68301457
50T cell selection (GO:0045058)3.67732666
51histone H4-K16 acetylation (GO:0043984)3.65089640
52protein localization to chromosome, centromeric region (GO:0071459)3.61336331
53cytidine metabolic process (GO:0046087)3.55536352
54cytidine catabolic process (GO:0006216)3.55536352
55cytidine deamination (GO:0009972)3.55536352
56B cell receptor signaling pathway (GO:0050853)3.54919119
57regulation of ARF GTPase activity (GO:0032312)3.54760036
58positive regulation of protein deacetylation (GO:0090312)3.54245201
59regulation of apoptotic process involved in morphogenesis (GO:1902337)3.53484590
60positive T cell selection (GO:0043368)3.48549268
61intestinal epithelial cell development (GO:0060576)3.42959256
62histone H3-K4 methylation (GO:0051568)3.42889133
63regulation of telomere maintenance (GO:0032204)3.42297484
64tachykinin receptor signaling pathway (GO:0007217)3.42227804
65GDP-mannose metabolic process (GO:0019673)3.41180669
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34749007
67nuclear pore complex assembly (GO:0051292)3.31884475
68positive regulation of Cdc42 GTPase activity (GO:0043089)3.31688635
69regulation of cilium movement (GO:0003352)3.29097145
70leukocyte aggregation (GO:0070486)3.28075634
71regulation of histone H3-K27 methylation (GO:0061085)3.24701142
72regulation of telomerase activity (GO:0051972)3.24628441
73regulation of B cell receptor signaling pathway (GO:0050855)3.23917819
74response to muramyl dipeptide (GO:0032495)3.20877715
75detection of bacterium (GO:0016045)3.20484883
76cell fate commitment involved in formation of primary germ layer (GO:0060795)3.20046421
77signal complex assembly (GO:0007172)3.19580608
78intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.19038328
79pseudouridine synthesis (GO:0001522)3.17428169
80histone H4 deacetylation (GO:0070933)3.13164971
81positive regulation of Rap GTPase activity (GO:0032854)3.13069049
82pore complex assembly (GO:0046931)3.09657578
83sister chromatid segregation (GO:0000819)3.07607971
84positive regulation of defense response to virus by host (GO:0002230)3.06935667
85germinal center formation (GO:0002467)3.06464818
86regulation of ARF protein signal transduction (GO:0032012)3.06330067
87heterochromatin organization (GO:0070828)3.06295180
88maintenance of protein localization in organelle (GO:0072595)3.02770564
89detection of other organism (GO:0098543)3.02291007
90ribosome biogenesis (GO:0042254)3.00994806
91quinone metabolic process (GO:1901661)3.00093018
92negative regulation of cell size (GO:0045792)2.99900064
93negative regulation of phagocytosis (GO:0050765)2.99483812
94negative regulation of interleukin-2 production (GO:0032703)2.96720173
95receptor recycling (GO:0001881)2.94480722
96regulation of interleukin-2 biosynthetic process (GO:0045076)2.91999514
97notochord development (GO:0030903)2.91902917
98mitochondrion distribution (GO:0048311)2.90090000
99phenol-containing compound catabolic process (GO:0019336)2.89649639
100regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.88493667
101NIK/NF-kappaB signaling (GO:0038061)2.88474322
102positive regulation of histone deacetylation (GO:0031065)2.87872192
103trophectodermal cell differentiation (GO:0001829)2.86468064
104chromatin assembly (GO:0031497)2.86290562
105regulation of necroptotic process (GO:0060544)2.84453470
106histone H3-K4 trimethylation (GO:0080182)2.83207354
107nucleoside transport (GO:0015858)2.82493654
108positive regulation of B cell differentiation (GO:0045579)2.82381934
109tolerance induction (GO:0002507)2.80868539
110modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.80309448
111positive regulation by organism of defense response of other organism involved in symbiotic interact2.80309448
112modulation by symbiont of host immune response (GO:0052553)2.80309448
113positive regulation by symbiont of host defense response (GO:0052509)2.80309448
114modulation by symbiont of host defense response (GO:0052031)2.80309448
115modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.80309448
116nuclear pore organization (GO:0006999)2.80085422
117response to dietary excess (GO:0002021)2.79965475
118phospholipid scrambling (GO:0017121)2.79792288
119regulation of extracellular matrix disassembly (GO:0010715)2.79334448
120negative regulation of myotube differentiation (GO:0010832)2.78869634
121retinoic acid receptor signaling pathway (GO:0048384)2.77812366
122response to laminar fluid shear stress (GO:0034616)2.76709717
123branching involved in labyrinthine layer morphogenesis (GO:0060670)2.76236392
124peptidyl-tyrosine autophosphorylation (GO:0038083)2.74837022
125DNA replication-dependent nucleosome assembly (GO:0006335)2.73491825
126DNA replication-dependent nucleosome organization (GO:0034723)2.73491825
127activation of JUN kinase activity (GO:0007257)2.70911675
128negative regulation of viral release from host cell (GO:1902187)2.70806617
129primitive streak formation (GO:0090009)2.70657526
130bone trabecula formation (GO:0060346)2.70148549
131histone H3 deacetylation (GO:0070932)2.69853368
132positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.69266646
133regulation of type I interferon-mediated signaling pathway (GO:0060338)2.67061108
134antigen processing and presentation via MHC class Ib (GO:0002475)2.66830618
135DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.66532866
136negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.65103689
137modulation by virus of host process (GO:0019054)2.64949140
138response to interleukin-15 (GO:0070672)2.64415271
139regulation of leukocyte degranulation (GO:0043300)2.63547252
140DNA damage response, detection of DNA damage (GO:0042769)2.63154148
141phagocytosis, recognition (GO:0006910)2.62181345
142negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61385819
143immunoglobulin mediated immune response (GO:0016064)2.61266294
144regulation of B cell differentiation (GO:0045577)2.60606920
145positive regulation of developmental pigmentation (GO:0048087)2.60600780
146regulation of DNA-dependent DNA replication (GO:0090329)2.60340718
147negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.60330484
148apoptotic DNA fragmentation (GO:0006309)2.59100710
149cyclooxygenase pathway (GO:0019371)2.57914095
150positive regulation of odontogenesis (GO:0042482)2.57602943
151activation of Rac GTPase activity (GO:0032863)2.56833679
152negative regulation of bone resorption (GO:0045779)2.56771210
153regulation of myeloid leukocyte mediated immunity (GO:0002886)2.56359042
154actin filament depolymerization (GO:0030042)2.56329886
155DNA duplex unwinding (GO:0032508)2.56146420
156negative regulation of leukocyte mediated immunity (GO:0002704)2.55662016
157regulation of Rap GTPase activity (GO:0032317)2.54508266
158negative regulation of lymphocyte mediated immunity (GO:0002707)2.54150304
159mitochondrial DNA replication (GO:0006264)2.54003160
160DNA geometric change (GO:0032392)2.53808825
161microtubule severing (GO:0051013)2.53736543
162intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.53394637
163DNA damage response, signal transduction resulting in transcription (GO:0042772)2.52451803
164B cell homeostasis (GO:0001782)2.51665208
165regulation of necrotic cell death (GO:0010939)2.51573967
166T cell migration (GO:0072678)2.51507698
167hormone catabolic process (GO:0042447)2.50568532
168antigen receptor-mediated signaling pathway (GO:0050851)2.50431423
169regulation of mast cell degranulation (GO:0043304)2.50058487
170regulation of double-strand break repair via homologous recombination (GO:0010569)2.49828098
171pyrimidine ribonucleoside catabolic process (GO:0046133)2.49811844
172positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.49761092
173establishment of endothelial barrier (GO:0061028)2.49307192
174poly(A)+ mRNA export from nucleus (GO:0016973)2.48506968
175negative regulation of necroptotic process (GO:0060546)2.47292081
176response to type I interferon (GO:0034340)2.47177610
177regulation of interferon-beta biosynthetic process (GO:0045357)2.46953781
178semaphorin-plexin signaling pathway (GO:0071526)2.45910974
179mucosal-associated lymphoid tissue development (GO:0048537)2.44782739
180Peyers patch development (GO:0048541)2.44782739
181modulation by symbiont of host cellular process (GO:0044068)2.44099937
182regulation of defense response to virus by virus (GO:0050690)2.44030641
183type I interferon signaling pathway (GO:0060337)2.42757641
184cellular response to type I interferon (GO:0071357)2.42757641
185embryonic process involved in female pregnancy (GO:0060136)2.41695660
186positive regulation of granulocyte differentiation (GO:0030854)2.40094777
187apoptotic process involved in morphogenesis (GO:0060561)2.39328280
188negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.38439788
189histone H3-K36 demethylation (GO:0070544)2.36936849
190megakaryocyte development (GO:0035855)2.36498261
191T cell receptor signaling pathway (GO:0050852)2.35962134
192positive regulation of protein dephosphorylation (GO:0035307)2.35675632
193skeletal muscle adaptation (GO:0043501)2.34965695
194activated T cell proliferation (GO:0050798)2.34025385
195regulation of dendritic cell antigen processing and presentation (GO:0002604)2.31872358
196Arp2/3 complex-mediated actin nucleation (GO:0034314)2.31711465
197macrophage activation involved in immune response (GO:0002281)2.31103889
198creatine metabolic process (GO:0006600)2.30705672

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.88138021
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.51187648
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.51187648
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.51187648
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.11031367
6E2F7_22180533_ChIP-Seq_HELA_Human5.03376185
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.45810196
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.39912204
9LXR_22292898_ChIP-Seq_THP-1_Human2.86210565
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.63245072
11KDM2B_26808549_Chip-Seq_DND41_Human2.44316989
12* ELK3_25401928_ChIP-Seq_HUVEC_Human2.40707647
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36979391
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.27659746
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.27509229
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22444927
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.18211586
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.15788977
19RACK7_27058665_Chip-Seq_MCF-7_Human2.06856093
20TCF3_18692474_ChIP-Seq_MESCs_Mouse2.06162928
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05938348
22VDR_24763502_ChIP-Seq_THP-1_Human2.04570797
23IRF1_19129219_ChIP-ChIP_H3396_Human2.00621651
24SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.99344932
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.97221258
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95184922
27NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.93860822
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93020640
29UTX_26944678_Chip-Seq_JUKART_Human1.91743908
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.90348811
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89866495
32TCF3_18692474_ChIP-Seq_MEFs_Mouse1.85758150
33SCL_19346495_ChIP-Seq_HPC-7_Human1.82138088
34MAF_26560356_Chip-Seq_TH2_Human1.81712015
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.78626189
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77811573
37MYC_22102868_ChIP-Seq_BL_Human1.76744268
38P68_20966046_ChIP-Seq_HELA_Human1.68930347
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.68329985
40CTCF_27219007_Chip-Seq_ERYTHROID_Human1.67674565
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66891640
42* KDM2B_26808549_Chip-Seq_K562_Human1.66115586
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62599227
44KDM2B_26808549_Chip-Seq_JURKAT_Human1.62564727
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62058245
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.57562090
47* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56578951
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.55897188
49SMC4_20622854_ChIP-Seq_HELA_Human1.53537608
50NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.53337625
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52785293
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.52281114
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.51295827
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48437605
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46469253
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45965076
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45379487
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45080473
59* ESR2_21235772_ChIP-Seq_MCF-7_Human1.45041676
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.42477073
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42393145
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.42315288
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41027200
64BCOR_27268052_Chip-Seq_Bcells_Human1.39824292
65BCL6_27268052_Chip-Seq_Bcells_Human1.38822109
66RUNX_20019798_ChIP-Seq_JUKART_Human1.37696819
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37462159
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36530490
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36258604
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36152975
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.35925384
72CREB1_26743006_Chip-Seq_LNCaP_Human1.35165458
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34818953
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34533058
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.33462720
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32042145
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31961134
78DROSHA_22980978_ChIP-Seq_HELA_Human1.30365363
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28674860
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28653932
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27971032
82NANOG_18692474_ChIP-Seq_MESCs_Mouse1.27284183
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26754282
84TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.26200699
85POU5F1_16518401_ChIP-PET_MESCs_Mouse1.25995888
86KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25097617
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23615245
88CDX2_20551321_ChIP-Seq_CACO-2_Human1.23434002
89PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23351583
90SPI1_23547873_ChIP-Seq_NB4_Human1.22491798
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21670791
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21542214
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.21360322
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21102902
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20978699
96MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20288793
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20280438
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19965433
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19908897
100MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18890341
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18790318
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17823706
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16758338
104CIITA_25753668_ChIP-Seq_RAJI_Human1.16402159
105POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.16263896
106STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16070164
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14642029
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14436276
109MYB_26560356_Chip-Seq_TH1_Human1.14281011
110NANOG_18692474_ChIP-Seq_MEFs_Mouse1.14100867
111PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13909402
112CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10642962
113GATA1_19941826_ChIP-Seq_K562_Human1.10489232
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10382333
115IRF8_22096565_ChIP-ChIP_GC-B_Human1.10227824
116EST1_17652178_ChIP-ChIP_JURKAT_Human1.10086992
117CTCF_27219007_Chip-Seq_Bcells_Human1.09765028
118MYC_18555785_ChIP-Seq_MESCs_Mouse1.09760836
119E2F1_17053090_ChIP-ChIP_MCF-7_Human1.09612782
120P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08178677
121FOXP3_21729870_ChIP-Seq_TREG_Human1.08063968
122MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06898454
123PHF8_20622854_ChIP-Seq_HELA_Human1.06771574
124CTCF_26484167_Chip-Seq_Bcells_Mouse1.06549907
125MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06487538
126PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06130655
127GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05136435
128E2F1_20622854_ChIP-Seq_HELA_Human1.04591100
129ETS1_21867929_ChIP-Seq_TH2_Mouse1.04106158
130NCOR1_26117541_ChIP-Seq_K562_Human1.03609446
131CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03559966
132TCF7_22412390_ChIP-Seq_EML_Mouse1.02732250
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02327338
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02026392
135PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.00572890
136SPI1_23127762_ChIP-Seq_K562_Human0.99573832
137SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97953672
138STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97225498
139* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97094386
140RUNX1_22412390_ChIP-Seq_EML_Mouse0.95639651
141* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95422836
142ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95029160
143POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94014499
144MYB_26560356_Chip-Seq_TH2_Human0.93775184
145VDR_21846776_ChIP-Seq_THP-1_Human0.90778660
146ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89229630
147CREB1_15753290_ChIP-ChIP_HEK293T_Human0.88680224
148SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87342442
149SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86364506
150EGR1_19374776_ChIP-ChIP_THP-1_Human0.85907344
151NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85688174
152FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.84340843
153IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83806674
154TP53_22127205_ChIP-Seq_IMR90_Human0.83723095
155OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82737180
156KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82704410
157ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82665232
158SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82416453
159TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81333681
160RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.80570875
161SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80318224
162KDM5A_27292631_Chip-Seq_BREAST_Human0.79672027
163KAP1_27257070_Chip-Seq_ESCs_Mouse0.79236007
164MYB_21317192_ChIP-Seq_ERMYB_Mouse0.77521402
165MAF_26560356_Chip-Seq_TH1_Human0.77226706
166VDR_23849224_ChIP-Seq_CD4+_Human0.76986863
167KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76644068
168IRF8_27001747_Chip-Seq_BMDM_Mouse0.75904402
169SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74850920
170NANOG_16518401_ChIP-PET_MESCs_Mouse0.74823866
171ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.73732843
172ELF1_17652178_ChIP-ChIP_JURKAT_Human0.73181282
173HIF1A_21447827_ChIP-Seq_MCF-7_Human0.72188418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.55904568
2MP0004264_abnormal_extraembryonic_tissu3.84681213
3MP0005075_abnormal_melanosome_morpholog3.69862404
4MP0008057_abnormal_DNA_replication3.26454055
5MP0005451_abnormal_body_composition3.03954256
6MP0002254_reproductive_system_inflammat2.99792330
7MP0003011_delayed_dark_adaptation2.97051067
8MP0005499_abnormal_olfactory_system2.75076939
9MP0005394_taste/olfaction_phenotype2.75076939
10MP0002396_abnormal_hematopoietic_system2.72835795
11MP0005058_abnormal_lysosome_morphology2.60471507
12MP0003890_abnormal_embryonic-extraembry2.46213204
13MP0001873_stomach_inflammation2.44328430
14MP0003303_peritoneal_inflammation2.43742420
15MP0002277_abnormal_respiratory_mucosa2.39657553
16MP0004957_abnormal_blastocyst_morpholog2.33149806
17MP0003183_abnormal_peptide_metabolism2.25375114
18MP0005257_abnormal_intraocular_pressure2.19590576
19MP0006082_CNS_inflammation2.16072290
20MP0003705_abnormal_hypodermis_morpholog2.13761218
21MP0003866_abnormal_defecation2.07145590
22MP0002132_abnormal_respiratory_system2.04574529
23MP0004858_abnormal_nervous_system1.99955300
24MP0003300_gastrointestinal_ulcer1.99291904
25MP0003111_abnormal_nucleus_morphology1.90299386
26MP0009278_abnormal_bone_marrow1.87255331
27MP0002419_abnormal_innate_immunity1.83000680
28MP0005671_abnormal_response_to1.82969998
29MP0003121_genomic_imprinting1.82677762
30MP0004947_skin_inflammation1.78891658
31MP0001835_abnormal_antigen_presentation1.75952155
32MP0005409_darkened_coat_color1.71104223
33MP0000490_abnormal_crypts_of1.70275049
34MP0003122_maternal_imprinting1.67588131
35MP0005310_abnormal_salivary_gland1.66722653
36MP0000678_abnormal_parathyroid_gland1.66615221
37MP0003724_increased_susceptibility_to1.64232295
38MP0003938_abnormal_ear_development1.61751649
39MP0003077_abnormal_cell_cycle1.58651707
40MP0002332_abnormal_exercise_endurance1.58211870
41MP0003191_abnormal_cellular_cholesterol1.57541939
42MP0010352_gastrointestinal_tract_polyps1.54736157
43MP0002822_catalepsy1.53282969
44MP0004381_abnormal_hair_follicle1.53170978
45MP0005076_abnormal_cell_differentiation1.50040964
46MP0003787_abnormal_imprinting1.49909255
47MP0009840_abnormal_foam_cell1.47411613
48MP0005387_immune_system_phenotype1.46766072
49MP0001790_abnormal_immune_system1.46766072
50MP0002653_abnormal_ependyma_morphology1.44964632
51MP0001800_abnormal_humoral_immune1.44149829
52MP0000751_myopathy1.43554917
53MP0002933_joint_inflammation1.42238886
54MP0005360_urolithiasis1.41552771
55MP0001293_anophthalmia1.39534707
56MP0005380_embryogenesis_phenotype1.38995293
57MP0001672_abnormal_embryogenesis/_devel1.38995293
58MP0005464_abnormal_platelet_physiology1.37575867
59MP0006035_abnormal_mitochondrial_morpho1.36863968
60MP0001533_abnormal_skeleton_physiology1.36775226
61MP0010094_abnormal_chromosome_stability1.32334700
62MP0004185_abnormal_adipocyte_glucose1.29967631
63MP0005666_abnormal_adipose_tissue1.27327182
64MP0003984_embryonic_growth_retardation1.25548392
65MP0002088_abnormal_embryonic_growth/wei1.24350295
66MP0005000_abnormal_immune_tolerance1.24237933
67MP0002398_abnormal_bone_marrow1.22626512
68MP0001819_abnormal_immune_cell1.20165613
69MP0002420_abnormal_adaptive_immunity1.20124814
70MP0000350_abnormal_cell_proliferation1.19687308
71MP0000465_gastrointestinal_hemorrhage1.18775775
72MP0003763_abnormal_thymus_physiology1.18503601
73MP0000716_abnormal_immune_system1.17854702
74MP0002452_abnormal_antigen_presenting1.17552075
75MP0003091_abnormal_cell_migration1.17512350
76MP0002722_abnormal_immune_system1.17096836
77MP0008058_abnormal_DNA_repair1.16715431
78MP0001663_abnormal_digestive_system1.16619341
79MP0000689_abnormal_spleen_morphology1.15001364
80MP0003693_abnormal_embryo_hatching1.14437665
81MP0008789_abnormal_olfactory_epithelium1.13990346
82MP0002405_respiratory_system_inflammati1.13255721
83MP0002723_abnormal_immune_serum1.12486190
84MP0001845_abnormal_inflammatory_respons1.11834809
85MP0003786_premature_aging1.09693794
86MP0008007_abnormal_cellular_replicative1.09628089
87MP0002092_abnormal_eye_morphology1.09442980
88MP0002127_abnormal_cardiovascular_syste1.08501803
89MP0008961_abnormal_basal_metabolism1.08252505
90MP0002998_abnormal_bone_remodeling1.08222646
91MP0002429_abnormal_blood_cell1.07384528
92MP0000313_abnormal_cell_death1.06443489
93MP0009333_abnormal_splenocyte_physiolog1.04745402
94MP0000733_abnormal_muscle_development1.03887197
95MP0004510_myositis1.03789161
96MP0004130_abnormal_muscle_cell1.02961659
97MP0003172_abnormal_lysosome_physiology1.02575801
98MP0005025_abnormal_response_to1.00903225
99MP0000759_abnormal_skeletal_muscle0.99672870
100MP0002138_abnormal_hepatobiliary_system0.95957855
101MP0005375_adipose_tissue_phenotype0.95924911
102MP0010155_abnormal_intestine_physiology0.95420932
103MP0003690_abnormal_glial_cell0.94905474
104MP0000747_muscle_weakness0.93656872
105MP0001545_abnormal_hematopoietic_system0.93567778
106MP0005397_hematopoietic_system_phenotyp0.93567778
107MP0003279_aneurysm0.93421994
108MP0005166_decreased_susceptibility_to0.92410189
109MP0004087_abnormal_muscle_fiber0.92363844
110MP0001849_ear_inflammation0.90997570
111MP0002932_abnormal_joint_morphology0.89959687
112MP0000762_abnormal_tongue_morphology0.89618564
113MP0000703_abnormal_thymus_morphology0.89367011
114MP0002086_abnormal_extraembryonic_tissu0.89045017
115MP0005381_digestive/alimentary_phenotyp0.87433813
116MP0006138_congestive_heart_failure0.87329193
117MP0003448_altered_tumor_morphology0.87048842
118MP0001664_abnormal_digestion0.86860618
119MP0002166_altered_tumor_susceptibility0.86541879
120MP0001765_abnormal_ion_homeostasis0.86098427
121MP0000049_abnormal_middle_ear0.85946558
122MP0002114_abnormal_axial_skeleton0.84941844
123MP0000003_abnormal_adipose_tissue0.84646485
124MP0000685_abnormal_immune_system0.84568460
125MP0002085_abnormal_embryonic_tissue0.83738632
126MP0008469_abnormal_protein_level0.83638852
127MP0000477_abnormal_intestine_morphology0.83457513
128MP0003315_abnormal_perineum_morphology0.81962466
129MP0001851_eye_inflammation0.81488534
130MP0003950_abnormal_plasma_membrane0.81211864
131MP0002019_abnormal_tumor_incidence0.79353155
132MP0004043_abnormal_pH_regulation0.79157893
133MP0003436_decreased_susceptibility_to0.78400686
134MP0001348_abnormal_lacrimal_gland0.78175218
135MP0000383_abnormal_hair_follicle0.78135948
136MP0001958_emphysema0.78069229
137MP0002249_abnormal_larynx_morphology0.77759771
138MP0000432_abnormal_head_morphology0.77563692
139MP0010630_abnormal_cardiac_muscle0.77342857
140MP0004036_abnormal_muscle_relaxation0.76757603
141MP0009785_altered_susceptibility_to0.76579167
142MP0000858_altered_metastatic_potential0.76147494
143MP0005391_vision/eye_phenotype0.73714029
144MP0008932_abnormal_embryonic_tissue0.73232113
145MP0008874_decreased_physiological_sensi0.72577307
146MP0009384_cardiac_valve_regurgitation0.72196217
147MP0003453_abnormal_keratinocyte_physiol0.72144089
148MP0000249_abnormal_blood_vessel0.72084055
149MP0002233_abnormal_nose_morphology0.70612218
150MP0000428_abnormal_craniofacial_morphol0.69885869
151MP0004808_abnormal_hematopoietic_stem0.69152932
152MP0002148_abnormal_hypersensitivity_rea0.68190624
153MP0003828_pulmonary_edema0.68029875
154MP0002098_abnormal_vibrissa_morphology0.67027988
155MP0005384_cellular_phenotype0.64785724
156MP0004782_abnormal_surfactant_physiolog0.64395784
157MP0008260_abnormal_autophagy0.64128400
158MP0003136_yellow_coat_color0.64096129

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.04692803
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.84798439
3Hypochromic microcytic anemia (HP:0004840)4.78011788
4Chromsome breakage (HP:0040012)4.34997313
5Rib fusion (HP:0000902)4.28246534
6Eczematoid dermatitis (HP:0000976)4.19419498
7Hepatoblastoma (HP:0002884)4.03998005
8Exercise-induced myalgia (HP:0003738)3.84628144
9Multiple enchondromatosis (HP:0005701)3.77200032
10Colitis (HP:0002583)3.76585386
11Broad face (HP:0000283)3.52665457
12Partial duplication of thumb phalanx (HP:0009944)3.47251442
13Hypoplasia of the fovea (HP:0007750)3.45314281
14Aplasia/Hypoplasia of the fovea (HP:0008060)3.45314281
15Intestinal fistula (HP:0100819)3.36700810
16Rectal fistula (HP:0100590)3.31704254
17Rectovaginal fistula (HP:0000143)3.31704254
18Ependymoma (HP:0002888)3.26527958
19Obstructive sleep apnea (HP:0002870)3.18992788
20Gastrointestinal inflammation (HP:0004386)3.16040502
21Myopathic facies (HP:0002058)3.10703872
22Thin bony cortex (HP:0002753)3.07608183
23Centrally nucleated skeletal muscle fibers (HP:0003687)3.04965850
24J-shaped sella turcica (HP:0002680)3.04832621
25Cheilitis (HP:0100825)3.00785610
26Inflammation of the large intestine (HP:0002037)2.97483866
27Nephroblastoma (Wilms tumor) (HP:0002667)2.97359254
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.94838828
29Meckel diverticulum (HP:0002245)2.94600180
30Distal lower limb amyotrophy (HP:0008944)2.92785700
31Cellulitis (HP:0100658)2.91586610
32Testicular atrophy (HP:0000029)2.85264273
33Reduced antithrombin III activity (HP:0001976)2.85209301
34Partial duplication of the phalanx of hand (HP:0009999)2.83435882
35Increased IgE level (HP:0003212)2.82510762
36Abnormality of the ileum (HP:0001549)2.81739956
37Agammaglobulinemia (HP:0004432)2.81056600
38Stridor (HP:0010307)2.78083055
39Hemorrhage of the eye (HP:0011885)2.76163933
40Abnormality of the salivary glands (HP:0010286)2.73633701
41Embryonal renal neoplasm (HP:0011794)2.70685478
42Abnormality of the fovea (HP:0000493)2.70472968
43Vaginal fistula (HP:0004320)2.68645001
44Flat acetabular roof (HP:0003180)2.66748627
45Abnormality of the lower motor neuron (HP:0002366)2.64888839
46Abnormality of glycolipid metabolism (HP:0010969)2.64826276
47Abnormality of liposaccharide metabolism (HP:0010968)2.64826276
48Abnormality of glycosphingolipid metabolism (HP:0004343)2.64826276
49Increased connective tissue (HP:0009025)2.64586409
50Neoplasm of striated muscle (HP:0009728)2.63298738
51Impulsivity (HP:0100710)2.60421807
52Anomalous pulmonary venous return (HP:0010772)2.59247660
53Pustule (HP:0200039)2.58872597
54Hypochromic anemia (HP:0001931)2.58542627
55Recurrent abscess formation (HP:0002722)2.58185654
56Nasolacrimal duct obstruction (HP:0000579)2.54574317
57Easy fatigability (HP:0003388)2.52726512
58Malnutrition (HP:0004395)2.49558977
59Rhabdomyosarcoma (HP:0002859)2.49038882
60Recurrent fungal infections (HP:0002841)2.46636835
61Gastrointestinal stroma tumor (HP:0100723)2.46506834
62Type I transferrin isoform profile (HP:0003642)2.46343146
63Abnormality of small intestinal villus morphology (HP:0011472)2.46010074
64Villous atrophy (HP:0011473)2.46010074
65Recurrent bacterial skin infections (HP:0005406)2.44774068
66Distal lower limb muscle weakness (HP:0009053)2.44137895
67Abnormal lung lobation (HP:0002101)2.42154202
68Duplication of thumb phalanx (HP:0009942)2.41918581
69Combined immunodeficiency (HP:0005387)2.41141468
70Meningitis (HP:0001287)2.41055415
71Abnormality of macrophages (HP:0004311)2.40418169
72Spontaneous hematomas (HP:0007420)2.39548540
73Cerebral aneurysm (HP:0004944)2.39084889
74Fused cervical vertebrae (HP:0002949)2.38704555
75Abnormality of the fingertips (HP:0001211)2.36670056
76Preauricular pit (HP:0004467)2.35045665
77Periauricular skin pits (HP:0100277)2.35045665
78Ankle clonus (HP:0011448)2.33988879
79Papilledema (HP:0001085)2.33278191
80Preauricular skin tag (HP:0000384)2.33069438
81Gingivitis (HP:0000230)2.29959460
82Obstructive lung disease (HP:0006536)2.27327102
83Chronic obstructive pulmonary disease (HP:0006510)2.27327102
84Abnormality of the preputium (HP:0100587)2.27314232
85Bifid tongue (HP:0010297)2.26719896
86Microvesicular hepatic steatosis (HP:0001414)2.23533993
87Small intestinal stenosis (HP:0012848)2.22937517
88Duodenal stenosis (HP:0100867)2.22937517
89Distal upper limb amyotrophy (HP:0007149)2.21002641
90Upper limb amyotrophy (HP:0009129)2.21002641
91Dysostosis multiplex (HP:0000943)2.20879651
92Abnormality of the astrocytes (HP:0100707)2.20474666
93Astrocytoma (HP:0009592)2.20474666
94Recurrent viral infections (HP:0004429)2.20317330
95Abnormality of the phalanges of the hallux (HP:0010057)2.19882401
96Abnormality of the distal phalanx of the thumb (HP:0009617)2.19531607
97Interstitial pulmonary disease (HP:0006530)2.18764465
98Prolonged bleeding time (HP:0003010)2.17986997
99Emphysema (HP:0002097)2.17887488
100Cervical subluxation (HP:0003308)2.17540969
101Shawl scrotum (HP:0000049)2.15189575
102Aplasia/hypoplasia of the humerus (HP:0006507)2.14581042
103Trismus (HP:0000211)2.13999568
104Bone marrow hypocellularity (HP:0005528)2.13914473
105Pendular nystagmus (HP:0012043)2.13766827
106Myelodysplasia (HP:0002863)2.13292543
107Abnormality of the pulmonary veins (HP:0011718)2.12362911
108Nasal polyposis (HP:0100582)2.11454341
109Mildly elevated creatine phosphokinase (HP:0008180)2.09951111
110Short humerus (HP:0005792)2.08990380
1113-Methylglutaconic aciduria (HP:0003535)2.07304684
112Tongue fasciculations (HP:0001308)2.06834296
113Skin tags (HP:0010609)2.05926219
114Abnormality of chromosome segregation (HP:0002916)2.04694928
115Mediastinal lymphadenopathy (HP:0100721)2.02278224
116Microretrognathia (HP:0000308)2.01480985
117Asymmetric septal hypertrophy (HP:0001670)1.97942314
118Verrucae (HP:0200043)1.97770665
119Papilloma (HP:0012740)1.97770665
120Abnormality of skeletal muscle fiber size (HP:0012084)1.97691444
121Amyotrophic lateral sclerosis (HP:0007354)1.96745482
122Metaphyseal cupping (HP:0003021)1.96659710
123EMG: neuropathic changes (HP:0003445)1.96274729
124Seborrheic dermatitis (HP:0001051)1.95965507
125Gastrointestinal infarctions (HP:0005244)1.94889070
126Chest pain (HP:0100749)1.94825227
127Aplasia/Hypoplasia of the macula (HP:0008059)1.94811849
128Large earlobe (HP:0009748)1.94742111
129Clubbing of toes (HP:0100760)1.94425061
130Ulnar deviation of the wrist (HP:0003049)1.94178942
131Lower limb amyotrophy (HP:0007210)1.93599599
132Myositis (HP:0100614)1.93223814
133Increased variability in muscle fiber diameter (HP:0003557)1.93003978
134Aplastic anemia (HP:0001915)1.92931539
135Hyperinsulinemic hypoglycemia (HP:0000825)1.91636393
136Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90603428
137Round ear (HP:0100830)1.90279949
138Sloping forehead (HP:0000340)1.90033451
139Horizontal nystagmus (HP:0000666)1.89773152
140Restrictive lung disease (HP:0002091)1.89236163
141Muscle fiber inclusion bodies (HP:0100299)1.88747753
142Volvulus (HP:0002580)1.88550786
143Elevated erythrocyte sedimentation rate (HP:0003565)1.88358347
144Orchitis (HP:0100796)1.88303282
145Deformed sella turcica (HP:0002681)1.87629560
146Muscle stiffness (HP:0003552)1.87459730
147Urinary glycosaminoglycan excretion (HP:0003541)1.86821004
148Mucopolysacchariduria (HP:0008155)1.86821004
149Vasculitis (HP:0002633)1.86606872
150Supranuclear gaze palsy (HP:0000605)1.86174298
151Spinal canal stenosis (HP:0003416)1.85882556
152Growth hormone excess (HP:0000845)1.85412120
153Hyperacusis (HP:0010780)1.84463785
154Slow saccadic eye movements (HP:0000514)1.84265431
155Neuronal loss in central nervous system (HP:0002529)1.84050402
156Abnormality of chromosome stability (HP:0003220)1.83718247
157Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83331652
158Recurrent cutaneous fungal infections (HP:0011370)1.83148767
159Chronic mucocutaneous candidiasis (HP:0002728)1.83148767
160Abnormality of the thoracic spine (HP:0100711)1.82846029
161Abnormality of the lacrimal duct (HP:0011481)1.81966862
162Panhypogammaglobulinemia (HP:0003139)1.81246684
163Upper limb muscle weakness (HP:0003484)1.80696742
164Aplasia/Hypoplasia of the sternum (HP:0006714)1.78998797
165Abnormal delayed hypersensitivity skin test (HP:0002963)1.78361190
166Fatigue (HP:0012378)1.78294807
167Supernumerary ribs (HP:0005815)1.78114098
168Sensory axonal neuropathy (HP:0003390)1.77283450
169Rhabdomyolysis (HP:0003201)1.77142267
170Generalized hypotonia (HP:0001290)1.76612833
171Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76408247
172Abnormality of polysaccharide metabolism (HP:0011012)1.76408247
173Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76408247
174Onion bulb formation (HP:0003383)1.76200829
175Tented upper lip vermilion (HP:0010804)1.76183819
176Recurrent skin infections (HP:0001581)1.76174576
177Glioma (HP:0009733)1.76019037
178Polygenic inheritance (HP:0010982)1.75378211
179Difficulty climbing stairs (HP:0003551)1.74485974
180Viral hepatitis (HP:0006562)1.73905502
181Osteomyelitis (HP:0002754)1.73680795
182Thoracic kyphosis (HP:0002942)1.73309729
183Nemaline bodies (HP:0003798)1.73296709
184Aneurysm (HP:0002617)1.72509063
185Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.72164045
186Annular pancreas (HP:0001734)1.71845866
187Skin pits (HP:0100276)1.71113044
188Prominent occiput (HP:0000269)1.70883594
189Reticulocytosis (HP:0001923)1.70033859
190Supernumerary spleens (HP:0009799)1.69385581
191Facial cleft (HP:0002006)1.69169773
192Muscle fibrillation (HP:0010546)1.68765543
193Abnormality of the duodenum (HP:0002246)1.67955003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.89194766
2GRK54.41675787
3GRK64.20045980
4TRIB33.96731607
5ADRBK23.59140268
6GRK13.52022364
7ERN13.35255366
8CSF1R3.27493661
9PRPF4B3.23857053
10RIPK42.67580971
11SIK12.65502517
12GRK72.52755554
13STK102.36424679
14MAPK72.35500750
15TGFBR22.34694651
16MAP2K32.34229289
17MATK2.25719280
18TTK2.20461279
19FGFR41.91515071
20MAP4K11.89410687
21WNK11.86784321
22TTN1.81658296
23SMG11.72606975
24EPHA21.71610288
25RIPK11.69242173
26EEF2K1.67432145
27MAP3K131.65799098
28CDK71.61532955
29MST1R1.60711086
30PRKG21.58175463
31ICK1.56408042
32AKT31.52391363
33PKN21.50781406
34TYRO31.49561904
35MARK21.43086412
36BLK1.42237674
37CDC42BPA1.38752646
38TBK11.34863282
39CAMK41.29337459
40PTK61.27279727
41FES1.25792426
42TXK1.24011968
43MOS1.16935777
44TAOK21.13993675
45CHEK21.10929137
46CSK1.05017440
47JAK11.02280940
48HIPK21.01890155
49MAP3K111.00661544
50ITK0.99872156
51IKBKB0.97260743
52CAMKK10.95936936
53IRAK30.94848037
54EIF2AK20.92447743
55MST40.92013175
56MAP3K60.91035076
57PAK40.89759114
58TAOK10.88991160
59KSR20.88764570
60PLK10.88094031
61MAP3K10.85945384
62NEK20.85735590
63PDPK10.84699664
64RPS6KA20.82594977
65PDGFRA0.81935177
66MAPK110.81906045
67MAP3K70.80866254
68CHEK10.80863752
69PDK10.79559903
70MAP3K30.79268055
71NTRK10.78873473
72KIT0.78038296
73ALK0.76131077
74RET0.74155052
75IKBKE0.73096157
76PIM20.71296850
77FGFR30.70775663
78IRAK40.69573302
79BMX0.69505008
80ADRBK10.67988159
81JAK30.65037117
82RPS6KC10.64370871
83RPS6KL10.64370871
84CLK10.62257797
85BUB10.61267188
86YES10.57830266
87MAPKAPK30.57133174
88CHUK0.57114925
89SIK20.56035345
90PRKCI0.55659789
91MARK30.54790868
92ZAP700.54385749
93MET0.53944977
94PIM10.53292954
95DYRK1B0.53168320
96TYK20.52528076
97LRRK20.52227480
98JAK20.52169957
99MAP2K60.52051904
100AKT20.50623822
101SYK0.50477105
102ZAK0.49645622
103LCK0.49445193
104HCK0.49032495
105MAPK120.48838018
106PTK2B0.46865859
107RPS6KB20.45619658
108RPS6KA60.45426146
109FYN0.44057440
110PRKCD0.43966652
111CDK20.43522147
112PRKD20.42194200
113MAP3K20.41915843
114STK40.41644414
115WEE10.41303237
116NME10.41063510
117MAP2K40.40918362
118TESK10.39980482
119PDGFRB0.39497258
120BRD40.39395498
121PRKCH0.39330250
122TNK20.39024615
123TRPM70.38828643
124OBSCN0.38532453
125PRKD10.38076962
126DDR20.37966222
127AURKB0.37360179
128PRKD30.37011653
129IGF1R0.36459790
130PAK10.35287272
131PIK3CA0.34908975
132MTOR0.34630541
133BTK0.34579286
134TEC0.34443265
135ATM0.33433867
136SRPK10.31360042
137LYN0.30354593
138MAP3K140.30078713
139EPHB10.29156866
140PKN10.28489478
141CDK40.27445448
142NLK0.27279944
143ATR0.26488005
144STK240.26073398
145MAPK10.25653879
146CDK10.24692079
147STK160.24363593
148MAPK140.24202514
149GSK3B0.24040561
150MAPKAPK20.23086558
151MAP2K20.21738571
152TESK20.21565704
153SIK30.20280606
154MKNK20.20148359
155INSR0.19288841
156STK30.18937196
157MAP3K100.18647935
158MAPK40.18274293

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.95545340
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.90068407
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.23606507
4Fructose and mannose metabolism_Homo sapiens_hsa000512.24152048
5Primary immunodeficiency_Homo sapiens_hsa053402.15686828
6Arachidonic acid metabolism_Homo sapiens_hsa005902.09595171
7Fanconi anemia pathway_Homo sapiens_hsa034602.01098905
8Other glycan degradation_Homo sapiens_hsa005111.96087677
9Homologous recombination_Homo sapiens_hsa034401.82840523
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.65882548
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63562054
12VEGF signaling pathway_Homo sapiens_hsa043701.63543811
13DNA replication_Homo sapiens_hsa030301.61304398
14Linoleic acid metabolism_Homo sapiens_hsa005911.57428631
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.56577547
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53931865
17RNA polymerase_Homo sapiens_hsa030201.52123198
18Galactose metabolism_Homo sapiens_hsa000521.51849765
19Chronic myeloid leukemia_Homo sapiens_hsa052201.48371688
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47393082
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.46755447
22Mismatch repair_Homo sapiens_hsa034301.44118049
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.44025615
24GnRH signaling pathway_Homo sapiens_hsa049121.42531489
25Base excision repair_Homo sapiens_hsa034101.41876446
26Regulation of autophagy_Homo sapiens_hsa041401.34055850
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33646427
28Viral myocarditis_Homo sapiens_hsa054161.27519128
29RNA transport_Homo sapiens_hsa030131.26957227
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.22774139
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21146336
32Herpes simplex infection_Homo sapiens_hsa051681.16070555
33Ether lipid metabolism_Homo sapiens_hsa005651.15070132
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14381359
35Hematopoietic cell lineage_Homo sapiens_hsa046401.13992953
36Inositol phosphate metabolism_Homo sapiens_hsa005621.12288677
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11970654
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09150094
39B cell receptor signaling pathway_Homo sapiens_hsa046621.07625529
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07555491
41Platelet activation_Homo sapiens_hsa046111.07098266
42RNA degradation_Homo sapiens_hsa030181.05063487
43Basal transcription factors_Homo sapiens_hsa030221.04591092
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02826406
45Cell cycle_Homo sapiens_hsa041101.02586426
46Insulin signaling pathway_Homo sapiens_hsa049101.02365059
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.02212151
48Staphylococcus aureus infection_Homo sapiens_hsa051500.97995997
49Spliceosome_Homo sapiens_hsa030400.97806226
50mRNA surveillance pathway_Homo sapiens_hsa030150.96901458
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96698230
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96229101
53T cell receptor signaling pathway_Homo sapiens_hsa046600.94503792
54Non-homologous end-joining_Homo sapiens_hsa034500.94437833
55Insulin resistance_Homo sapiens_hsa049310.94225734
56Type I diabetes mellitus_Homo sapiens_hsa049400.93676151
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93341247
58Acute myeloid leukemia_Homo sapiens_hsa052210.92480499
59ErbB signaling pathway_Homo sapiens_hsa040120.91629783
60Hepatitis B_Homo sapiens_hsa051610.91007579
61Asthma_Homo sapiens_hsa053100.90781432
62Prolactin signaling pathway_Homo sapiens_hsa049170.90349834
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.90012193
64Estrogen signaling pathway_Homo sapiens_hsa049150.89028240
65TNF signaling pathway_Homo sapiens_hsa046680.88735713
66Endometrial cancer_Homo sapiens_hsa052130.87877203
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86670140
68Renal cell carcinoma_Homo sapiens_hsa052110.86370339
69Long-term potentiation_Homo sapiens_hsa047200.85137808
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84939538
71Measles_Homo sapiens_hsa051620.84493353
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.84157318
73Leishmaniasis_Homo sapiens_hsa051400.84063260
74Glioma_Homo sapiens_hsa052140.83814587
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83794981
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82088925
77Ribosome_Homo sapiens_hsa030100.81250793
78Endocytosis_Homo sapiens_hsa041440.80756780
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.80602003
80Apoptosis_Homo sapiens_hsa042100.79962993
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79467144
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78516939
83p53 signaling pathway_Homo sapiens_hsa041150.78431528
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78012756
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.77378199
86Folate biosynthesis_Homo sapiens_hsa007900.76769933
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75075224
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74610936
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72526809
90Nucleotide excision repair_Homo sapiens_hsa034200.72497377
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.72345774
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71562587
93Influenza A_Homo sapiens_hsa051640.71096615
94Pathways in cancer_Homo sapiens_hsa052000.68923509
95Choline metabolism in cancer_Homo sapiens_hsa052310.67547075
96Colorectal cancer_Homo sapiens_hsa052100.66788483
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65244813
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65223890
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.64814231
100mTOR signaling pathway_Homo sapiens_hsa041500.64025231
101Pyrimidine metabolism_Homo sapiens_hsa002400.62737778
102MAPK signaling pathway_Homo sapiens_hsa040100.62021360
103AMPK signaling pathway_Homo sapiens_hsa041520.61771898
104Antigen processing and presentation_Homo sapiens_hsa046120.59706653
105Notch signaling pathway_Homo sapiens_hsa043300.59617536
106African trypanosomiasis_Homo sapiens_hsa051430.58811032
107Pentose phosphate pathway_Homo sapiens_hsa000300.58376727
108Graft-versus-host disease_Homo sapiens_hsa053320.58339985
109One carbon pool by folate_Homo sapiens_hsa006700.57471237
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56720202
111Allograft rejection_Homo sapiens_hsa053300.55370181
112HIF-1 signaling pathway_Homo sapiens_hsa040660.55223279
113Glucagon signaling pathway_Homo sapiens_hsa049220.54921712
114Gastric acid secretion_Homo sapiens_hsa049710.54884118
115Lysosome_Homo sapiens_hsa041420.54680126
116Shigellosis_Homo sapiens_hsa051310.53635367
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53617700
118Pancreatic secretion_Homo sapiens_hsa049720.53317605
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52768019
120Sphingolipid metabolism_Homo sapiens_hsa006000.52294353
121Pertussis_Homo sapiens_hsa051330.52259862
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51964164
123MicroRNAs in cancer_Homo sapiens_hsa052060.51802920
124Cholinergic synapse_Homo sapiens_hsa047250.51575046
125Oxytocin signaling pathway_Homo sapiens_hsa049210.51437723
126Autoimmune thyroid disease_Homo sapiens_hsa053200.50003892
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49611235
128Thyroid cancer_Homo sapiens_hsa052160.49025089
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46810944
130HTLV-I infection_Homo sapiens_hsa051660.46478054
131Ovarian steroidogenesis_Homo sapiens_hsa049130.46118405
132Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45276098
133Chemokine signaling pathway_Homo sapiens_hsa040620.44955331
134Pancreatic cancer_Homo sapiens_hsa052120.44894081
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44056613
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43222645
137Hepatitis C_Homo sapiens_hsa051600.43220438
138Rap1 signaling pathway_Homo sapiens_hsa040150.42324889
139Tuberculosis_Homo sapiens_hsa051520.41081862
140Non-small cell lung cancer_Homo sapiens_hsa052230.41039641
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40894516
142Osteoclast differentiation_Homo sapiens_hsa043800.40020646
143Epstein-Barr virus infection_Homo sapiens_hsa051690.39756913
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.39582011
145Basal cell carcinoma_Homo sapiens_hsa052170.39022159
146Toxoplasmosis_Homo sapiens_hsa051450.36941102
147Legionellosis_Homo sapiens_hsa051340.36910501
148Viral carcinogenesis_Homo sapiens_hsa052030.36897982
149Taste transduction_Homo sapiens_hsa047420.35906271

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