OSBPL9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.55496724
2nuclear pore organization (GO:0006999)6.66489659
3pore complex assembly (GO:0046931)5.44605732
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.01297518
5L-phenylalanine catabolic process (GO:0006559)5.01297518
6fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.96367493
7aromatic amino acid family catabolic process (GO:0009074)4.85565475
8L-phenylalanine metabolic process (GO:0006558)4.83756403
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.83756403
10lysine catabolic process (GO:0006554)4.75155368
11lysine metabolic process (GO:0006553)4.75155368
12tryptophan catabolic process (GO:0006569)4.68055312
13indole-containing compound catabolic process (GO:0042436)4.68055312
14indolalkylamine catabolic process (GO:0046218)4.68055312
15regulation of RNA export from nucleus (GO:0046831)4.57615696
16Golgi transport vesicle coating (GO:0048200)4.56859333
17COPI coating of Golgi vesicle (GO:0048205)4.56859333
18complement activation, alternative pathway (GO:0006957)4.45554147
19glyoxylate metabolic process (GO:0046487)4.44024153
20tryptophan metabolic process (GO:0006568)4.42405859
21alpha-linolenic acid metabolic process (GO:0036109)4.41820571
22kynurenine metabolic process (GO:0070189)4.38470864
23cysteine metabolic process (GO:0006534)4.38210787
24regulation of protein activation cascade (GO:2000257)4.18681376
25triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.13548937
26mitotic chromosome condensation (GO:0007076)4.13533215
27amino-acid betaine metabolic process (GO:0006577)4.12892812
28sister chromatid segregation (GO:0000819)4.11190132
29DNA unwinding involved in DNA replication (GO:0006268)4.09750072
30homocysteine metabolic process (GO:0050667)4.09279514
31formation of translation preinitiation complex (GO:0001731)4.09167933
32urea metabolic process (GO:0019627)4.06806095
33urea cycle (GO:0000050)4.06806095
34regulation of complement activation (GO:0030449)4.05075483
35mitotic sister chromatid segregation (GO:0000070)4.03137236
36protein carboxylation (GO:0018214)4.01153851
37peptidyl-glutamic acid carboxylation (GO:0017187)4.01153851
38sulfur amino acid catabolic process (GO:0000098)3.99433579
39valine metabolic process (GO:0006573)3.97980071
40bile acid biosynthetic process (GO:0006699)3.97626685
41mitotic nuclear envelope disassembly (GO:0007077)3.89363183
42urate metabolic process (GO:0046415)3.89120722
43nitrogen cycle metabolic process (GO:0071941)3.78385220
44fatty acid beta-oxidation (GO:0006635)3.76157430
45COPII vesicle coating (GO:0048208)3.74369335
46regulation of mitotic spindle organization (GO:0060236)3.73562118
47negative regulation of fibrinolysis (GO:0051918)3.72601440
48ethanol oxidation (GO:0006069)3.72150522
49regulation of triglyceride catabolic process (GO:0010896)3.71487362
50DNA topological change (GO:0006265)3.68847224
51nuclear envelope disassembly (GO:0051081)3.68452999
52membrane disassembly (GO:0030397)3.68452999
53fatty acid oxidation (GO:0019395)3.66651550
542-oxoglutarate metabolic process (GO:0006103)3.64093651
55regulation of centriole replication (GO:0046599)3.62581355
56lipid oxidation (GO:0034440)3.62424068
57regulation of nucleobase-containing compound transport (GO:0032239)3.56877073
58carnitine metabolic process (GO:0009437)3.56676413
59drug transmembrane transport (GO:0006855)3.55606724
60ribosome assembly (GO:0042255)3.54113600
61mitotic sister chromatid cohesion (GO:0007064)3.52967472
62positive regulation of fatty acid beta-oxidation (GO:0032000)3.52197118
63serine family amino acid catabolic process (GO:0009071)3.51614864
64regulation of fibrinolysis (GO:0051917)3.47919625
65short-chain fatty acid metabolic process (GO:0046459)3.46783440
66regulation of translational fidelity (GO:0006450)3.41916103
67fatty acid catabolic process (GO:0009062)3.41068436
68regulation of spindle organization (GO:0090224)3.40260171
69aromatic amino acid family metabolic process (GO:0009072)3.38837910
70cellular ketone body metabolic process (GO:0046950)3.38011608
71drug catabolic process (GO:0042737)3.36876221
72DNA duplex unwinding (GO:0032508)3.32474411
73ribonucleoprotein complex disassembly (GO:0032988)3.32195393
74high-density lipoprotein particle remodeling (GO:0034375)3.31746639
75alpha-amino acid catabolic process (GO:1901606)3.29915135
76acylglycerol homeostasis (GO:0055090)3.29835831
77triglyceride homeostasis (GO:0070328)3.29835831
78DNA strand elongation involved in DNA replication (GO:0006271)3.29594902
79bile acid metabolic process (GO:0008206)3.28407543
80acetyl-CoA metabolic process (GO:0006084)3.28118413
81plasma lipoprotein particle clearance (GO:0034381)3.26884430
82regulation of sequestering of triglyceride (GO:0010889)3.25847157
83complement activation (GO:0006956)3.25764317
84monocarboxylic acid catabolic process (GO:0072329)3.25629654
85complement activation, classical pathway (GO:0006958)3.25121873
86tyrosine metabolic process (GO:0006570)3.22416720
87DNA geometric change (GO:0032392)3.21731486
88fibrinolysis (GO:0042730)3.20946093
89benzene-containing compound metabolic process (GO:0042537)3.19797143
90regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19333397
91DNA strand elongation (GO:0022616)3.18804916
92branched-chain amino acid metabolic process (GO:0009081)3.18606045
93phospholipid homeostasis (GO:0055091)3.18085723
94regulation of cholesterol homeostasis (GO:2000188)3.17451432
95positive regulation of fatty acid oxidation (GO:0046321)3.16398956
96indolalkylamine metabolic process (GO:0006586)3.15994966
97DNA replication initiation (GO:0006270)3.15623180
98fatty acid transmembrane transport (GO:1902001)3.15139604
99reverse cholesterol transport (GO:0043691)3.14727577
100non-recombinational repair (GO:0000726)3.14705169
101double-strand break repair via nonhomologous end joining (GO:0006303)3.14705169
102regulation of histone H3-K27 methylation (GO:0061085)3.14669274
103cellular glucuronidation (GO:0052695)3.13059246
104positive regulation of lipid catabolic process (GO:0050996)3.11309105
105mitotic metaphase plate congression (GO:0007080)3.11240966
106cellular amino acid catabolic process (GO:0009063)3.10025900
107tricarboxylic acid metabolic process (GO:0072350)3.09647986
108vesicle coating (GO:0006901)3.09078546
109cellular modified amino acid catabolic process (GO:0042219)3.08264441
110regulation of fatty acid beta-oxidation (GO:0031998)3.06299333
111exogenous drug catabolic process (GO:0042738)3.06224302
112tricarboxylic acid cycle (GO:0006099)3.03097466
113cellular biogenic amine catabolic process (GO:0042402)3.02371659
114amine catabolic process (GO:0009310)3.02371659
115epoxygenase P450 pathway (GO:0019373)3.00238308
116organic acid catabolic process (GO:0016054)3.00179405
117carboxylic acid catabolic process (GO:0046395)3.00179405
118protein localization to kinetochore (GO:0034501)2.99777264
119negative regulation of protein activation cascade (GO:2000258)2.99366336
120plasma lipoprotein particle remodeling (GO:0034369)2.98965761
121protein-lipid complex remodeling (GO:0034368)2.98965761
122macromolecular complex remodeling (GO:0034367)2.98965761
123protein localization to chromosome, centromeric region (GO:0071459)2.98955825
124drug transport (GO:0015893)2.98821217
125establishment of integrated proviral latency (GO:0075713)2.98790049
126aspartate family amino acid catabolic process (GO:0009068)2.98421286
127dicarboxylic acid biosynthetic process (GO:0043650)2.98254391
128branched-chain amino acid catabolic process (GO:0009083)2.97906423
129DNA conformation change (GO:0071103)2.97477233
130phospholipid efflux (GO:0033700)2.97391428
131protein activation cascade (GO:0072376)2.96755137
132protein export from nucleus (GO:0006611)2.93950525
133tRNA aminoacylation for protein translation (GO:0006418)2.92046656
134negative regulation of chromosome segregation (GO:0051985)2.91521900
135retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.91405175
136low-density lipoprotein particle clearance (GO:0034383)2.90857137
137mitotic spindle checkpoint (GO:0071174)2.90446939
138mitotic spindle assembly checkpoint (GO:0007094)2.90166773
139regulation of chromosome segregation (GO:0051983)2.90004782
140negative regulation of cholesterol transport (GO:0032375)2.89951012
141negative regulation of sterol transport (GO:0032372)2.89951012
142glutamate metabolic process (GO:0006536)2.89917959
143response to mercury ion (GO:0046689)2.89653299
144ethanol metabolic process (GO:0006067)2.89428466
145biotin metabolic process (GO:0006768)2.88663317
146negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88597281
147negative regulation of mitotic sister chromatid separation (GO:2000816)2.88597281
148negative regulation of sister chromatid segregation (GO:0033046)2.88597281
149negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88597281
150negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88597281
151chromosome condensation (GO:0030261)2.87627967
152regulation of sister chromatid cohesion (GO:0007063)2.86841915
153spindle assembly checkpoint (GO:0071173)2.86775066
154glucuronate metabolic process (GO:0019585)2.86501958
155uronic acid metabolic process (GO:0006063)2.86501958
156nuclear envelope organization (GO:0006998)2.82626750
157metaphase plate congression (GO:0051310)2.82213006
158regulation of mitotic metaphase/anaphase transition (GO:0030071)2.82075349
159regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.82075349
160spindle checkpoint (GO:0031577)2.81833548
161amino acid activation (GO:0043038)2.79944185
162tRNA aminoacylation (GO:0043039)2.79944185
163regulation of centrosome cycle (GO:0046605)2.78612908
164positive regulation of cell cycle checkpoint (GO:1901978)2.75447867
165telomere maintenance via semi-conservative replication (GO:0032201)2.71255264
166DNA replication checkpoint (GO:0000076)2.70583851
167regulation of sister chromatid segregation (GO:0033045)2.70548527
168regulation of mitotic sister chromatid separation (GO:0010965)2.70548527
169regulation of mitotic sister chromatid segregation (GO:0033047)2.70548527
170definitive hemopoiesis (GO:0060216)2.69713006
171pre-miRNA processing (GO:0031054)2.69165173
172establishment of chromosome localization (GO:0051303)2.65472246
173mitotic recombination (GO:0006312)2.65386607
174mRNA transport (GO:0051028)2.64820331
175telomere maintenance via recombination (GO:0000722)2.63695274
176chromosome segregation (GO:0007059)2.62981764
177DNA packaging (GO:0006323)2.61802487
178regulation of centrosome duplication (GO:0010824)2.61721048
179mitotic G2/M transition checkpoint (GO:0044818)2.60698404
180purine nucleobase biosynthetic process (GO:0009113)2.57993512
181protoporphyrinogen IX metabolic process (GO:0046501)2.56735628
182nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.54294840
183regulation of histone H3-K9 methylation (GO:0051570)2.51851544
184IMP biosynthetic process (GO:0006188)2.50929356
185monoubiquitinated protein deubiquitination (GO:0035520)2.49243338
186histone H2B ubiquitination (GO:0033523)2.48678280
187diterpenoid biosynthetic process (GO:0016102)2.47415551
188kinetochore organization (GO:0051383)2.46476549
189mitotic G2 DNA damage checkpoint (GO:0007095)2.46244191
190IMP metabolic process (GO:0046040)2.44008747
191glutamine metabolic process (GO:0006541)2.43723634
192regulation of histone H3-K4 methylation (GO:0051569)2.41476346
193peptidyl-lysine dimethylation (GO:0018027)2.40287745
194histone H3-K9 demethylation (GO:0033169)2.39526009
195DNA ligation (GO:0006266)2.39519070
196regulation of DNA damage checkpoint (GO:2000001)2.39154307
197negative regulation of histone methylation (GO:0031061)2.38875098
198organelle disassembly (GO:1903008)2.38688293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.08067621
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.52468774
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.51318414
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.86176203
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.81844878
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.47582869
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.21141371
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.77553563
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.72446168
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.31288925
11AR_21909140_ChIP-Seq_LNCAP_Human3.27071117
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.24175386
13PRDM5_23873026_ChIP-Seq_MEFs_Mouse3.04553070
14IRF8_22096565_ChIP-ChIP_GC-B_Human3.03683038
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.96314985
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.77441667
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.76895136
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.75850333
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.75365551
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60884152
21* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.50307344
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.49876760
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.47708960
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41952948
25* CLOCK_20551151_ChIP-Seq_293T_Human2.41390150
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40085098
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.35965021
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32848319
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30267511
30E2F1_21310950_ChIP-Seq_MCF-7_Human2.29758728
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26205075
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20487959
33ELK1_19687146_ChIP-ChIP_HELA_Human2.16829618
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.15654433
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.13064298
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.09226400
37RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08033460
38ZFX_18555785_ChIP-Seq_MESCs_Mouse2.05094658
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97591729
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97309423
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.95967808
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.95903579
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95715798
44* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92864221
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91941790
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77237525
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76047890
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.75131653
49DCP1A_22483619_ChIP-Seq_HELA_Human1.74696222
50RUNX_20019798_ChIP-Seq_JUKART_Human1.74255503
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74211775
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71939110
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.68744704
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65746828
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64034245
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62027984
57* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60154312
58TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.59722861
59IRF8_21731497_ChIP-ChIP_J774_Mouse1.57767982
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.56567921
61* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.54879032
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.54544039
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.52768753
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50791312
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.48667506
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.48362797
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48360372
68* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47212571
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45941645
70GATA1_22025678_ChIP-Seq_K562_Human1.42154913
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41727379
72XRN2_22483619_ChIP-Seq_HELA_Human1.41357458
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37953236
74* FOXA2_19822575_ChIP-Seq_HepG2_Human1.37306929
75TFEB_21752829_ChIP-Seq_HELA_Human1.37064932
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.37029877
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35474692
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34037871
79SOX17_20123909_ChIP-Seq_XEN_Mouse1.33774128
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.32048370
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.30083651
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28904062
83TRIM28_21343339_ChIP-Seq_HEK293_Human1.28423802
84* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26791509
85CHD1_26751641_Chip-Seq_LNCaP_Human1.26210560
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.26095716
87GATA4_21415370_ChIP-Seq_HL-1_Mouse1.26089140
88TTF2_22483619_ChIP-Seq_HELA_Human1.23444711
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23216201
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21204294
91FOXP3_21729870_ChIP-Seq_TREG_Human1.20965245
92FOXO3_23340844_ChIP-Seq_DLD1_Human1.20815927
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19649156
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18687585
95* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18515775
96* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17601295
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16301763
98* KDM5A_27292631_Chip-Seq_BREAST_Human1.15237913
99GABP_19822575_ChIP-Seq_HepG2_Human1.14575600
100* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13996367
101FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12431618
102NANOG_21062744_ChIP-ChIP_HESCs_Human1.11928067
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11873431
104NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11623436
105CJUN_26792858_Chip-Seq_BT549_Human1.10617889
106VDR_23849224_ChIP-Seq_CD4+_Human1.10187455
107STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09209698
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08565085
109MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08541944
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06922384
111BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06530626
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06489222
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04428005
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03571813
115ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03383244
116ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02862179
117ZNF263_19887448_ChIP-Seq_K562_Human1.02772719
118TBX20_22328084_ChIP-Seq_HEART_Mouse1.02157252
119TBX20_22080862_ChIP-Seq_HEART_Mouse1.02157252
120* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01842589
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01698103
122CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01253022
123EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00744297
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98637337
125VDR_24787735_ChIP-Seq_THP-1_Human0.97173655
126* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95432819
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94671252
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93933762
129* HNF4A_19822575_ChIP-Seq_HepG2_Human0.91835942
130E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91592362
131SRF_21415370_ChIP-Seq_HL-1_Mouse0.91293365
132NCOR1_26117541_ChIP-Seq_K562_Human0.91282232
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89842249
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89842249
135* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89327222
136* MAF_26560356_Chip-Seq_TH1_Human0.88759755
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88688178
138CIITA_25753668_ChIP-Seq_RAJI_Human0.88564883
139TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88075370
140CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87989644
141NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87723641
142CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87213019
143EGR1_19032775_ChIP-ChIP_M12_Human0.87156279
144* GATA2_19941826_ChIP-Seq_K562_Human0.86563512
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86526587
146CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86287926
147* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85924177
148GATA4_25053715_ChIP-Seq_YYC3_Human0.85441643
149SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85274070
150FUS_26573619_Chip-Seq_HEK293_Human0.84431235
151DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84210958
152POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84191042
153ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84159897
154TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83838591
155RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83604085
156GATA6_25053715_ChIP-Seq_YYC3_Human0.83556386
157SOX2_27498859_Chip-Seq_STOMACH_Mouse0.81730632
158GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81178771
159SOX2_20726797_ChIP-Seq_SW620_Human0.81090195
160* MYB_26560356_Chip-Seq_TH2_Human0.80598469
161BCAT_22108803_ChIP-Seq_LS180_Human0.79906956
162* MYB_26560356_Chip-Seq_TH1_Human0.79083595
163FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78807018
164ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78129532
165* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.77257503
166PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75988542
167SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75491491
168EP300_21415370_ChIP-Seq_HL-1_Mouse0.75408027
169* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.74673232
170PU_27001747_Chip-Seq_BMDM_Mouse0.73887234
171PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73757679
172JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73093161
173FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72799594
174SMAD_19615063_ChIP-ChIP_OVARY_Human0.71140765
175PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.70805454
176SOX9_24532713_ChIP-Seq_HFSC_Mouse0.70252140
177GATA1_19941827_ChIP-Seq_MEL_Mouse0.70228970
178* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.69277405
179BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.69041307
180GATA1_19941826_ChIP-Seq_K562_Human0.68092043
181AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68038736
182JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66958875
183SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66631655
184HIF1A_21447827_ChIP-Seq_MCF-7_Human0.66311470
185CEBPB_22108803_ChIP-Seq_LS180_Human0.65900110
186ELK3_25401928_ChIP-Seq_HUVEC_Human0.65790120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.56572525
2MP0002139_abnormal_hepatobiliary_system5.47509305
3MP0005365_abnormal_bile_salt3.96174793
4MP0008057_abnormal_DNA_replication3.90442848
5MP0005085_abnormal_gallbladder_physiolo3.80663863
6MP0008875_abnormal_xenobiotic_pharmacok3.44806421
7MP0010094_abnormal_chromosome_stability3.11375361
8MP0004957_abnormal_blastocyst_morpholog2.93644464
9MP0003111_abnormal_nucleus_morphology2.85640332
10MP0003252_abnormal_bile_duct2.80097535
11MP0002138_abnormal_hepatobiliary_system2.68260325
12MP0010329_abnormal_lipoprotein_level2.62307625
13MP0003077_abnormal_cell_cycle2.51284784
14MP0005332_abnormal_amino_acid2.50187738
15MP0003191_abnormal_cellular_cholesterol2.46598019
16MP0005408_hypopigmentation2.43758654
17MP0002877_abnormal_melanocyte_morpholog2.35102513
18MP0003693_abnormal_embryo_hatching2.32121409
19MP0003941_abnormal_skin_development2.30993925
20MP0009840_abnormal_foam_cell2.26109908
21MP0008932_abnormal_embryonic_tissue2.16023714
22MP0008058_abnormal_DNA_repair2.12250450
23MP0003221_abnormal_cardiomyocyte_apopto2.07102332
24MP0005670_abnormal_white_adipose2.06562258
25MP0003806_abnormal_nucleotide_metabolis2.03192632
26MP0004019_abnormal_vitamin_homeostasis1.99014887
27MP0005171_absent_coat_pigmentation1.97991430
28MP0003724_increased_susceptibility_to1.97458778
29MP0001730_embryonic_growth_arrest1.95301263
30MP0008007_abnormal_cellular_replicative1.94012648
31MP0010352_gastrointestinal_tract_polyps1.93072209
32MP0003984_embryonic_growth_retardation1.89509065
33MP0003195_calcinosis1.87784945
34MP0003950_abnormal_plasma_membrane1.86057475
35MP0004272_abnormal_basement_membrane1.85274809
36MP0002088_abnormal_embryonic_growth/wei1.84888595
37MP0001672_abnormal_embryogenesis/_devel1.84840255
38MP0005380_embryogenesis_phenotype1.84840255
39MP0005083_abnormal_biliary_tract1.84781627
40MP0000609_abnormal_liver_physiology1.83817781
41MP0001697_abnormal_embryo_size1.76811963
42MP0000350_abnormal_cell_proliferation1.70924863
43MP0009643_abnormal_urine_homeostasis1.70902615
44MP0010368_abnormal_lymphatic_system1.70733197
45MP0003705_abnormal_hypodermis_morpholog1.70426457
46MP0004233_abnormal_muscle_weight1.69148994
47MP0000372_irregular_coat_pigmentation1.66330371
48MP0002118_abnormal_lipid_homeostasis1.61736020
49MP0004130_abnormal_muscle_cell1.60539337
50MP0003300_gastrointestinal_ulcer1.58948190
51MP0008438_abnormal_cutaneous_collagen1.57671798
52MP0004084_abnormal_cardiac_muscle1.56705178
53MP0002086_abnormal_extraembryonic_tissu1.55965265
54MP0005319_abnormal_enzyme/_coenzyme1.54840911
55MP0010307_abnormal_tumor_latency1.54012092
56MP0004264_abnormal_extraembryonic_tissu1.52006685
57MP0002084_abnormal_developmental_patter1.50050660
58MP0003436_decreased_susceptibility_to1.49352586
59MP0009764_decreased_sensitivity_to1.49261376
60MP0001835_abnormal_antigen_presentation1.49093914
61MP0002269_muscular_atrophy1.48764813
62MP0003567_abnormal_fetal_cardiomyocyte1.46346549
63MP0005584_abnormal_enzyme/coenzyme_acti1.46175733
64MP0002080_prenatal_lethality1.45492124
65MP0001958_emphysema1.45333940
66MP0001666_abnormal_nutrient_absorption1.41976850
67MP0002009_preneoplasia1.39757007
68MP0002396_abnormal_hematopoietic_system1.37147541
69MP0003890_abnormal_embryonic-extraembry1.35336790
70MP0005666_abnormal_adipose_tissue1.35175645
71MP0005058_abnormal_lysosome_morphology1.35071744
72MP0001915_intracranial_hemorrhage1.33088051
73MP0003385_abnormal_body_wall1.30145185
74MP0008995_early_reproductive_senescence1.29692134
75MP0002136_abnormal_kidney_physiology1.26545371
76MP0005248_abnormal_Harderian_gland1.25016790
77MP0003786_premature_aging1.22900095
78MP0009672_abnormal_birth_weight1.22242830
79MP0010630_abnormal_cardiac_muscle1.21452769
80MP0002085_abnormal_embryonic_tissue1.20759763
81MP0001879_abnormal_lymphatic_vessel1.20027394
82MP0008469_abnormal_protein_level1.19799398
83MP0003718_maternal_effect1.19789231
84MP0005076_abnormal_cell_differentiation1.19537868
85MP0004197_abnormal_fetal_growth/weight/1.16941720
86MP0001661_extended_life_span1.16847339
87MP0005275_abnormal_skin_tensile1.16628820
88MP0002697_abnormal_eye_size1.14936113
89MP0001756_abnormal_urination1.14884268
90MP0005464_abnormal_platelet_physiology1.12909638
91MP0004036_abnormal_muscle_relaxation1.12437756
92MP0009785_altered_susceptibility_to1.11604676
93MP0005387_immune_system_phenotype1.11008328
94MP0001790_abnormal_immune_system1.11008328
95MP0003943_abnormal_hepatobiliary_system1.09950664
96MP0002971_abnormal_brown_adipose1.07131526
97MP0003186_abnormal_redox_activity1.06449019
98MP0009763_increased_sensitivity_to1.06014027
99MP0001800_abnormal_humoral_immune1.05472913
100MP0000313_abnormal_cell_death1.03629721
101MP0009703_decreased_birth_body1.03277078
102MP0002419_abnormal_innate_immunity1.03175599
103MP0000685_abnormal_immune_system1.03037511
104MP0000598_abnormal_liver_morphology1.01940041
105MP0005451_abnormal_body_composition1.01438470
106MP0006138_congestive_heart_failure1.00044998
107MP0002837_dystrophic_cardiac_calcinosis0.99462393
108MP0002166_altered_tumor_susceptibility0.99356327
109MP0004782_abnormal_surfactant_physiolog0.99178194
110MP0002168_other_aberrant_phenotype0.99057933
111MP0001764_abnormal_homeostasis0.99033118
112MP0001845_abnormal_inflammatory_respons0.98782520
113MP0000371_diluted_coat_color0.98762626
114MP0000358_abnormal_cell_content/0.98633772
115MP0002254_reproductive_system_inflammat0.98225127
116MP0003279_aneurysm0.98015735
117MP0004087_abnormal_muscle_fiber0.96858949
118MP0001853_heart_inflammation0.96795254
119MP0000747_muscle_weakness0.96586860
120MP0004147_increased_porphyrin_level0.96128676
121MP0003937_abnormal_limbs/digits/tail_de0.94898773
122MP0005636_abnormal_mineral_homeostasis0.93801914
123MP0003656_abnormal_erythrocyte_physiolo0.92846649
124MP0006082_CNS_inflammation0.92828414
125MP0004185_abnormal_adipocyte_glucose0.92450720
126MP0000343_altered_response_to0.92425207
127MP0005621_abnormal_cell_physiology0.92041333
128MP0004947_skin_inflammation0.91642517
129MP0005025_abnormal_response_to0.90746653
130MP0005384_cellular_phenotype0.90716806
131MP0008260_abnormal_autophagy0.89293568
132MP0003868_abnormal_feces_composition0.88922142
133MP0009384_cardiac_valve_regurgitation0.86289844
134MP0002092_abnormal_eye_morphology0.86240402
135MP0001533_abnormal_skeleton_physiology0.86143776
136MP0001293_anophthalmia0.85985636
137MP0002452_abnormal_antigen_presenting0.85289745
138MP0003566_abnormal_cell_adhesion0.85281344
139MP0008775_abnormal_heart_ventricle0.85080010
140MP0002938_white_spotting0.84844126
141MP0005023_abnormal_wound_healing0.84785568
142MP0005334_abnormal_fat_pad0.83290172
143MP0005330_cardiomyopathy0.82707677
144MP0003935_abnormal_craniofacial_develop0.81786224
145MP0009697_abnormal_copulation0.81745043
146MP0000249_abnormal_blood_vessel0.81402427
147MP0009115_abnormal_fat_cell0.81265581
148MP0005000_abnormal_immune_tolerance0.81106633
149MP0009642_abnormal_blood_homeostasis0.80920653
150MP0003303_peritoneal_inflammation0.79953631
151MP0005375_adipose_tissue_phenotype0.79874261
152MP0004808_abnormal_hematopoietic_stem0.78737002
153MP0002723_abnormal_immune_serum0.77872824
154MP0005647_abnormal_sex_gland0.77639174
155MP0000604_amyloidosis0.77585380
156MP0000266_abnormal_heart_morphology0.77530130
157MP0002933_joint_inflammation0.76569289
158MP0001727_abnormal_embryo_implantation0.76166259
159MP0001286_abnormal_eye_development0.75937430
160MP0000751_myopathy0.75769256
161MP0003115_abnormal_respiratory_system0.75523378
162MP0005671_abnormal_response_to0.75069709
163MP0005167_abnormal_blood-brain_barrier0.74979778
164MP0002060_abnormal_skin_morphology0.73389691
165MP0002928_abnormal_bile_duct0.72989965
166MP0005166_decreased_susceptibility_to0.72031598
167MP0006035_abnormal_mitochondrial_morpho0.71611532
168MP0000537_abnormal_urethra_morphology0.71315491
169MP0001765_abnormal_ion_homeostasis0.70926831
170MP0003011_delayed_dark_adaptation0.70837450
171MP0010234_abnormal_vibrissa_follicle0.70308823
172MP0002135_abnormal_kidney_morphology0.69531223
173MP0002132_abnormal_respiratory_system0.67980705
174MP0010155_abnormal_intestine_physiology0.66313597
175MP0010678_abnormal_skin_adnexa0.65480314
176MP0000428_abnormal_craniofacial_morphol0.65097580
177MP0002075_abnormal_coat/hair_pigmentati0.64746870
178MP0002405_respiratory_system_inflammati0.64301162
179MP0002420_abnormal_adaptive_immunity0.64181217
180MP0002128_abnormal_blood_circulation0.64075887
181MP0002078_abnormal_glucose_homeostasis0.63543299
182MP0001819_abnormal_immune_cell0.63474536
183MP0002925_abnormal_cardiovascular_devel0.62998760
184MP0002019_abnormal_tumor_incidence0.62905722
185MP0005187_abnormal_penis_morphology0.62152813

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.11445681
2Xanthomatosis (HP:0000991)4.57615565
3Complement deficiency (HP:0004431)4.55719217
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.44436676
5Intrahepatic cholestasis (HP:0001406)4.14440199
6Papillary thyroid carcinoma (HP:0002895)4.13948565
7Abnormality of glutamine family amino acid metabolism (HP:0010902)3.91035134
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.90082732
9Hyperglycinuria (HP:0003108)3.85102801
10Hyperlipoproteinemia (HP:0010980)3.81452707
11Joint hemorrhage (HP:0005261)3.72970254
12Cortical dysplasia (HP:0002539)3.72941211
13Prolonged partial thromboplastin time (HP:0003645)3.62274420
14Hyperammonemia (HP:0001987)3.60863192
15Ketosis (HP:0001946)3.56355496
16Hypoalphalipoproteinemia (HP:0003233)3.48217610
17Chromsome breakage (HP:0040012)3.45648618
18Systemic lupus erythematosus (HP:0002725)3.43036485
19Abnormality of serine family amino acid metabolism (HP:0010894)3.41535853
20Abnormality of glycine metabolism (HP:0010895)3.41535853
21Abnormality of fatty-acid metabolism (HP:0004359)3.40641795
22Myocardial infarction (HP:0001658)3.40628446
23Abnormality of complement system (HP:0005339)3.37075427
24Abnormality of glycolysis (HP:0004366)3.30860315
25Abnormality of the common coagulation pathway (HP:0010990)3.26389506
26Increased serum pyruvate (HP:0003542)3.21766968
27Cholecystitis (HP:0001082)3.15709567
28Abnormal gallbladder physiology (HP:0012438)3.15709567
29Ketoacidosis (HP:0001993)3.10445517
30Gout (HP:0001997)3.09389621
31Abnormality of purine metabolism (HP:0004352)3.08278685
32Hypolipoproteinemia (HP:0010981)3.03987476
33Chromosomal breakage induced by crosslinking agents (HP:0003221)3.03794801
34Hyperglycinemia (HP:0002154)3.02159150
35Recurrent gram-negative bacterial infections (HP:0005420)3.00965829
36Abnormality of aspartate family amino acid metabolism (HP:0010899)2.97604205
37Hypobetalipoproteinemia (HP:0003563)2.93875057
38Epidermoid cyst (HP:0200040)2.93726273
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.91573078
40Nephroblastoma (Wilms tumor) (HP:0002667)2.88391509
41Mitral stenosis (HP:0001718)2.86472499
42Abnormality of sulfur amino acid metabolism (HP:0004339)2.85243730
43Thyroid carcinoma (HP:0002890)2.83780271
44Hypoglycemic coma (HP:0001325)2.83210369
45Termporal pattern (HP:0011008)2.82881475
46Insidious onset (HP:0003587)2.82881475
47Vascular calcification (HP:0004934)2.79908238
48Abnormality of nucleobase metabolism (HP:0010932)2.74564760
49Glomerulonephritis (HP:0000099)2.73168917
50Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.71245280
51Cardiovascular calcification (HP:0011915)2.70500182
52Embryonal renal neoplasm (HP:0011794)2.68076670
53Acute myeloid leukemia (HP:0004808)2.65256608
54Overlapping toe (HP:0001845)2.61397324
55Abnormality of proline metabolism (HP:0010907)2.59292817
56Hydroxyprolinuria (HP:0003080)2.59292817
57Asymmetry of the thorax (HP:0001555)2.58465274
58Nephritis (HP:0000123)2.56541993
59Hypercholesterolemia (HP:0003124)2.54233029
60Increased nuchal translucency (HP:0010880)2.50226846
61Abnormality of the intrinsic pathway (HP:0010989)2.47585784
62Proximal tubulopathy (HP:0000114)2.44923977
63Fat malabsorption (HP:0002630)2.41150889
64Metabolic acidosis (HP:0001942)2.40774628
65Hyperuricemia (HP:0002149)2.40011085
66Increased purine levels (HP:0004368)2.40011085
67Ankyloglossia (HP:0010296)2.38065661
68Spontaneous hematomas (HP:0007420)2.37910172
69Generalized aminoaciduria (HP:0002909)2.37680382
70Skin nodule (HP:0200036)2.37118243
71Esophageal varix (HP:0002040)2.36626852
72Dicarboxylic aciduria (HP:0003215)2.32261017
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32261017
74Deep philtrum (HP:0002002)2.31109962
75Abnormality of methionine metabolism (HP:0010901)2.26895771
76Reticulocytosis (HP:0001923)2.26890104
77Orthostatic hypotension (HP:0001278)2.26638506
78Conjugated hyperbilirubinemia (HP:0002908)2.25216659
79Abnormality of serum amino acid levels (HP:0003112)2.25058840
80Polycythemia (HP:0001901)2.23506024
81Abnormality of chromosome stability (HP:0003220)2.22804021
82Sensorimotor neuropathy (HP:0007141)2.19620276
83Thrombophlebitis (HP:0004418)2.18089602
84Medulloblastoma (HP:0002885)2.16155713
85Microglossia (HP:0000171)2.16150543
86Hypokalemic alkalosis (HP:0001949)2.14222969
87Hepatocellular carcinoma (HP:0001402)2.13916456
88Alkalosis (HP:0001948)2.13200144
89Microvesicular hepatic steatosis (HP:0001414)2.13129150
90Hyperactive renin-angiotensin system (HP:0000841)2.11033662
91Alacrima (HP:0000522)2.10226789
92Gingival bleeding (HP:0000225)2.08864714
93Abnormality of pyrimidine metabolism (HP:0004353)2.07136912
94Pheochromocytoma (HP:0002666)2.05389920
95Neoplasm of the small intestine (HP:0100833)2.05005500
96Delayed CNS myelination (HP:0002188)2.04497655
97Breech presentation (HP:0001623)2.03868609
98Hypertriglyceridemia (HP:0002155)2.03286662
99Abnormal lung lobation (HP:0002101)2.03079999
100Pancreatitis (HP:0001733)2.03007097
101Pulmonary embolism (HP:0002204)2.02846809
102Ovarian neoplasm (HP:0100615)1.99469784
103Vacuolated lymphocytes (HP:0001922)1.98303304
104Sandal gap (HP:0001852)1.98272778
105Eczematoid dermatitis (HP:0000976)1.98046880
106Right ventricular cardiomyopathy (HP:0011663)1.97096132
107Myoglobinuria (HP:0002913)1.95629312
108Interstitial pulmonary disease (HP:0006530)1.95129842
109Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94883879
110Neonatal onset (HP:0003623)1.94789682
111Exercise-induced muscle cramps (HP:0003710)1.93143692
112Acanthocytosis (HP:0001927)1.92796667
113Hyperbilirubinemia (HP:0002904)1.92678425
114Gonadotropin excess (HP:0000837)1.88675239
115Aortic aneurysm (HP:0004942)1.88430094
116Hemorrhage of the eye (HP:0011885)1.87779808
117Decreased lacrimation (HP:0000633)1.87556625
118Lymphangioma (HP:0100764)1.86525287
119Spastic diplegia (HP:0001264)1.86149485
120Rhabdomyosarcoma (HP:0002859)1.82904917
121Hypoparathyroidism (HP:0000829)1.82736761
122Steatorrhea (HP:0002570)1.82493548
123Autoimmune thrombocytopenia (HP:0001973)1.82466119
124Pancreatic islet-cell hyperplasia (HP:0004510)1.81510756
125Abnormality of chloride homeostasis (HP:0011422)1.81203372
126Cholelithiasis (HP:0001081)1.80791142
127Multiple enchondromatosis (HP:0005701)1.80521323
128Amyloidosis (HP:0011034)1.79585373
129Abnormality of the nasal mucosa (HP:0000433)1.79340191
130Hypopigmentation of the fundus (HP:0007894)1.78298293
131Lower limb hyperreflexia (HP:0002395)1.78230295
132Hematochezia (HP:0002573)1.78134012
133Long clavicles (HP:0000890)1.78033391
134Proximal placement of thumb (HP:0009623)1.76933224
135Relative macrocephaly (HP:0004482)1.76112344
136Myelodysplasia (HP:0002863)1.75530912
137Rimmed vacuoles (HP:0003805)1.75390402
138Renal cortical cysts (HP:0000803)1.75269857
139Broad palm (HP:0001169)1.75185940
140Axonal loss (HP:0003447)1.74881938
141Colitis (HP:0002583)1.74762469
142Upper limb muscle weakness (HP:0003484)1.74720014
143Abnormal enzyme/coenzyme activity (HP:0012379)1.74663048
144Bowel incontinence (HP:0002607)1.74626772
145Deviation of the thumb (HP:0009603)1.74565898
146Lethargy (HP:0001254)1.74336461
147Abnormal gallbladder morphology (HP:0012437)1.73440144
148Vomiting (HP:0002013)1.72092723
149Leiomyosarcoma (HP:0100243)1.71921229
150Uterine leiomyosarcoma (HP:0002891)1.71921229
151Cutaneous melanoma (HP:0012056)1.71578110
152Rhabdomyolysis (HP:0003201)1.71140195
153Abnormality of oral frenula (HP:0000190)1.70409321
154Hepatoblastoma (HP:0002884)1.70209793
155Spontaneous abortion (HP:0005268)1.70119436
156Menorrhagia (HP:0000132)1.70103395
157Volvulus (HP:0002580)1.68139122
158Arterial thrombosis (HP:0004420)1.67819626
159Chondrocalcinosis (HP:0000934)1.65993963
160Aortic dissection (HP:0002647)1.65660585
161Birth length less than 3rd percentile (HP:0003561)1.65423142
162Abnormal foot bone ossification (HP:0010675)1.65113319
163Long toe (HP:0010511)1.64975703
164Abnormality of the acetabulum (HP:0003170)1.64947664
165Secondary amenorrhea (HP:0000869)1.64798235
166Arterial tortuosity (HP:0005116)1.64368903
167Obsessive-compulsive behavior (HP:0000722)1.64229023
168Flat acetabular roof (HP:0003180)1.64189776
169Abnormal large intestine physiology (HP:0012700)1.63628282
170Facial cleft (HP:0002006)1.62014443
171Gonadal dysgenesis (HP:0000133)1.61602493
172Neoplasm of the thyroid gland (HP:0100031)1.60671029
173Palpitations (HP:0001962)1.59677746
174Truncus arteriosus (HP:0001660)1.59498218
175Cafe-au-lait spot (HP:0000957)1.59027516
176Entropion (HP:0000621)1.58101531
177Freckling (HP:0001480)1.57571387
178Abnormal auditory evoked potentials (HP:0006958)1.57400203
179Abnormality of reticulocytes (HP:0004312)1.56595064
180Impaired pain sensation (HP:0007328)1.55956650
181Abnormality of pain sensation (HP:0010832)1.55956650
182Subaortic stenosis (HP:0001682)1.55194570
183Abnormality of the left ventricular outflow tract (HP:0011103)1.55194570
184Seborrheic dermatitis (HP:0001051)1.55100839
185Rhizomelia (HP:0008905)1.54529624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTK3.38447917
2ERN13.33428137
3TGFBR23.21236647
4TRIB33.04474986
5FGFR43.03024277
6BCKDK2.96025183
7EIF2AK32.93809775
8EIF2AK12.92872816
9SRPK12.90471729
10SCYL22.65235089
11PLK42.65023255
12PBK2.52338072
13NEK12.42023838
14BCR2.16647149
15BRD42.13737072
16CDC72.10147112
17MAP4K12.09444469
18CDK122.08436294
19SIK12.05177483
20TIE12.04221239
21PKN22.00674862
22CLK11.93989402
23TTN1.90898575
24BRSK21.88617683
25RIPK11.86628257
26TYK21.80008896
27JAK11.73820671
28KSR21.72177092
29TAOK31.71547237
30TBK11.68253923
31EPHB11.67835470
32NEK91.67492606
33BMPR21.58726570
34BLK1.58337823
35KDR1.57748099
36BUB11.52625087
37EPHA31.51423965
38MAP3K21.46069246
39RPS6KB21.44336836
40MAP2K31.40985825
41TSSK61.40650533
42PTK61.39293882
43MAP3K141.38342531
44WEE11.35182214
45JAK31.33673832
46FGFR31.33626383
47ICK1.32359875
48RAF11.30524255
49AKT31.30491623
50FLT31.30092853
51CSK1.29139535
52CAMK1D1.28318352
53PIK3CG1.24121329
54MKNK11.23689223
55IKBKE1.22594923
56ZAP701.22413959
57WNK41.20982154
58MST1R1.20953820
59KIT1.20798082
60MAP3K41.18502176
61STK101.15605187
62LATS11.14454938
63PRKAA21.14044583
64IRAK31.13403537
65KSR11.13173023
66MAP3K31.12218624
67MST41.10481972
68ITK1.09436576
69MET1.08989599
70LRRK21.08915706
71JAK21.06072129
72OBSCN1.03760545
73LATS21.03165177
74PLK31.03029808
75ERBB31.03007723
76ATR1.01994081
77MAP3K131.01669668
78CHEK11.00607241
79INSRR1.00070575
80TXK0.98007347
81WNK30.97006124
82TEC0.96494795
83FGFR10.95857765
84TRIM280.95548310
85MAP3K70.95374768
86NLK0.95356172
87ATM0.94882489
88MAPK110.93490238
89ERBB40.92625932
90PLK10.91321810
91BTK0.90632985
92MAPKAPK30.89384465
93PAK40.89098904
94PDK40.88914030
95PDK30.88914030
96CCNB10.88450700
97EEF2K0.85248675
98RPS6KA40.85134778
99CSF1R0.83974449
100NEK20.83930220
101YES10.83661462
102CDK70.82751224
103IRAK10.79806463
104FRK0.79323943
105AURKB0.79181002
106TRPM70.78585528
107CHEK20.77652777
108PDK20.77495766
109TGFBR10.76781380
110MYLK0.76299019
111CAMK1G0.75730544
112GRK60.74574940
113IRAK40.74497238
114MAPK120.74328904
115PRKCH0.73893138
116STK240.72537225
117HCK0.71905446
118MAP3K120.71829815
119PIK3CA0.71790778
120TNIK0.71119469
121SGK30.70022891
122CDK40.69394726
123MAP3K100.69278954
124NEK60.68815592
125CDK90.68028935
126PDGFRA0.67760101
127PRKAA10.66878570
128CDK10.66497615
129LMTK20.65565419
130DMPK0.65397319
131MTOR0.65156597
132DYRK1B0.64968492
133CDK60.64740898
134CDK20.63843891
135MAP3K60.61978504
136IKBKB0.59820084
137MAPK40.59198556
138EIF2AK20.57009867
139ALK0.56575342
140AKT20.56547698
141PAK20.55689801
142IGF1R0.53926248
143STK40.53786406
144CHUK0.52820557
145GRK10.52352102
146MAP3K80.52189963
147PTK20.51665658
148EPHB20.50916125
149SGK20.49884964
150PINK10.49262039
151FER0.49254745
152IRAK20.49178958
153RET0.48625186
154CSNK1E0.48091875
155ABL10.47825509
156CSNK1A1L0.47582201
157SYK0.47421555
158PRKCQ0.46041732
159FGFR20.45676699
160MAP2K40.45124992
161STK30.44681625
162GSK3A0.44311247
163NME10.43996374
164LCK0.43214235
165MAP3K110.43009257
166STK38L0.42666186
167BRSK10.42217305
168CDK80.39551224
169MKNK20.39348685
170CSNK2A20.38062687
171PRKDC0.36212908
172RPS6KB10.34494815
173SIK30.33488510
174MAPK140.32671821

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.40225750
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.39636924
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.02838578
4Fatty acid degradation_Homo sapiens_hsa000712.94968893
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.92625972
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72928708
7Nitrogen metabolism_Homo sapiens_hsa009102.72335900
8Complement and coagulation cascades_Homo sapiens_hsa046102.65557077
9Mismatch repair_Homo sapiens_hsa034302.59523543
10Tryptophan metabolism_Homo sapiens_hsa003802.54413833
11Propanoate metabolism_Homo sapiens_hsa006402.51094553
12DNA replication_Homo sapiens_hsa030302.50193208
13Non-homologous end-joining_Homo sapiens_hsa034502.48390570
14Arginine biosynthesis_Homo sapiens_hsa002202.37106334
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.30084763
16PPAR signaling pathway_Homo sapiens_hsa033202.28838405
17Staphylococcus aureus infection_Homo sapiens_hsa051502.26681541
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22355476
19One carbon pool by folate_Homo sapiens_hsa006702.14933827
20Fatty acid metabolism_Homo sapiens_hsa012122.13822692
21RNA transport_Homo sapiens_hsa030132.10295430
22Cell cycle_Homo sapiens_hsa041102.09373832
23Peroxisome_Homo sapiens_hsa041462.03050120
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02578165
25Caffeine metabolism_Homo sapiens_hsa002322.00352592
26Butanoate metabolism_Homo sapiens_hsa006501.99386849
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86237161
28beta-Alanine metabolism_Homo sapiens_hsa004101.85019683
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84804140
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79644422
31Spliceosome_Homo sapiens_hsa030401.73358505
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65746658
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.63690451
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.62376353
35Nucleotide excision repair_Homo sapiens_hsa034201.60133852
36Histidine metabolism_Homo sapiens_hsa003401.58113084
37mRNA surveillance pathway_Homo sapiens_hsa030151.56740052
38Pyruvate metabolism_Homo sapiens_hsa006201.54103900
39Chemical carcinogenesis_Homo sapiens_hsa052041.48582531
40Homologous recombination_Homo sapiens_hsa034401.46372603
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43882564
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43570885
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41505328
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.39821269
45Phenylalanine metabolism_Homo sapiens_hsa003601.38959584
46Bile secretion_Homo sapiens_hsa049761.37949273
47Thyroid cancer_Homo sapiens_hsa052161.35667463
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34003090
49Starch and sucrose metabolism_Homo sapiens_hsa005001.32667145
50Adherens junction_Homo sapiens_hsa045201.32507360
51Retinol metabolism_Homo sapiens_hsa008301.31625724
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29474849
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28892328
54Base excision repair_Homo sapiens_hsa034101.27330135
55Fanconi anemia pathway_Homo sapiens_hsa034601.26723166
56ABC transporters_Homo sapiens_hsa020101.20478750
57Carbon metabolism_Homo sapiens_hsa012001.18220720
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16888909
59Basal transcription factors_Homo sapiens_hsa030221.09593119
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09097422
61Central carbon metabolism in cancer_Homo sapiens_hsa052301.06882108
62Drug metabolism - other enzymes_Homo sapiens_hsa009831.05203057
63Proteasome_Homo sapiens_hsa030501.05153201
64Tyrosine metabolism_Homo sapiens_hsa003501.05037400
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04714129
66p53 signaling pathway_Homo sapiens_hsa041151.03571202
67Chronic myeloid leukemia_Homo sapiens_hsa052201.01715905
68Selenocompound metabolism_Homo sapiens_hsa004501.00806143
69Lysine degradation_Homo sapiens_hsa003100.95890182
70Fructose and mannose metabolism_Homo sapiens_hsa000510.95684137
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94050523
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.91593655
73RNA degradation_Homo sapiens_hsa030180.90804633
74Vitamin digestion and absorption_Homo sapiens_hsa049770.90073251
75Glycerolipid metabolism_Homo sapiens_hsa005610.89937059
76Fatty acid biosynthesis_Homo sapiens_hsa000610.88240063
77Small cell lung cancer_Homo sapiens_hsa052220.85916801
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.81996321
79Biosynthesis of amino acids_Homo sapiens_hsa012300.81467331
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81178962
81N-Glycan biosynthesis_Homo sapiens_hsa005100.80073281
82Galactose metabolism_Homo sapiens_hsa000520.77575918
83Fatty acid elongation_Homo sapiens_hsa000620.75950605
84Sulfur relay system_Homo sapiens_hsa041220.74686920
85Non-small cell lung cancer_Homo sapiens_hsa052230.74402099
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73118725
87Oocyte meiosis_Homo sapiens_hsa041140.72857967
88Arginine and proline metabolism_Homo sapiens_hsa003300.72282907
89Insulin resistance_Homo sapiens_hsa049310.71620444
90Renal cell carcinoma_Homo sapiens_hsa052110.70809448
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70593845
92Viral carcinogenesis_Homo sapiens_hsa052030.68312570
93Colorectal cancer_Homo sapiens_hsa052100.68222832
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.66810260
95Folate biosynthesis_Homo sapiens_hsa007900.66303167
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65130647
97Sulfur metabolism_Homo sapiens_hsa009200.63809743
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.63671332
99Fat digestion and absorption_Homo sapiens_hsa049750.63088510
100MicroRNAs in cancer_Homo sapiens_hsa052060.60062666
101Other glycan degradation_Homo sapiens_hsa005110.58123093
102Circadian rhythm_Homo sapiens_hsa047100.57891695
103Endometrial cancer_Homo sapiens_hsa052130.57546135
104mTOR signaling pathway_Homo sapiens_hsa041500.57162146
105Pentose phosphate pathway_Homo sapiens_hsa000300.54328982
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52914549
107Protein export_Homo sapiens_hsa030600.51988622
108Prostate cancer_Homo sapiens_hsa052150.51925667
109Lysosome_Homo sapiens_hsa041420.50740562
110TGF-beta signaling pathway_Homo sapiens_hsa043500.49287891
111Glutathione metabolism_Homo sapiens_hsa004800.48413831
112HIF-1 signaling pathway_Homo sapiens_hsa040660.48323857
113Malaria_Homo sapiens_hsa051440.48310402
114Pyrimidine metabolism_Homo sapiens_hsa002400.47516306
115Inositol phosphate metabolism_Homo sapiens_hsa005620.45920002
116Tight junction_Homo sapiens_hsa045300.45374595
117Focal adhesion_Homo sapiens_hsa045100.44459940
118Primary immunodeficiency_Homo sapiens_hsa053400.44271358
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42078919
120Osteoclast differentiation_Homo sapiens_hsa043800.40163833
121B cell receptor signaling pathway_Homo sapiens_hsa046620.39456095
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38311258
123ErbB signaling pathway_Homo sapiens_hsa040120.38230076
124Acute myeloid leukemia_Homo sapiens_hsa052210.37737183
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37679280
126Proteoglycans in cancer_Homo sapiens_hsa052050.37040393
127Hepatitis B_Homo sapiens_hsa051610.37012424
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36727461
129Purine metabolism_Homo sapiens_hsa002300.35533931
130Leishmaniasis_Homo sapiens_hsa051400.32552266
131AMPK signaling pathway_Homo sapiens_hsa041520.31691651
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.31337831
133Vitamin B6 metabolism_Homo sapiens_hsa007500.31275701
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.29902334
135Toxoplasmosis_Homo sapiens_hsa051450.29414279
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.28570999
137Amoebiasis_Homo sapiens_hsa051460.28408089
138Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25288471
139Pancreatic cancer_Homo sapiens_hsa052120.25248732
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.23896938
141Steroid biosynthesis_Homo sapiens_hsa001000.20575126
142Metabolic pathways_Homo sapiens_hsa011000.19172868
143TNF signaling pathway_Homo sapiens_hsa046680.18553445
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17927810
145AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.17358684
146Hepatitis C_Homo sapiens_hsa051600.17143865
147ECM-receptor interaction_Homo sapiens_hsa045120.17087007
148Renin-angiotensin system_Homo sapiens_hsa046140.17008448
149RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16767371
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.16579587
151Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15628047
152Glucagon signaling pathway_Homo sapiens_hsa049220.15601317
153Measles_Homo sapiens_hsa051620.14819552
154Insulin signaling pathway_Homo sapiens_hsa049100.14741645
155Pertussis_Homo sapiens_hsa051330.13879696
156Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.12708106
157Tuberculosis_Homo sapiens_hsa051520.12312203

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