ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of dendritic spine morphogenesis (GO:0061003)	7.22968204
2	central nervous system projection neuron axonogenesis (GO:0021952)	7.06059972
3	cell migration in hindbrain (GO:0021535)	6.96820469
4	cerebral cortex radially oriented cell migration (GO:0021799)	6.61578293
5	limb bud formation (GO:0060174)	6.23599184
6	pyrimidine nucleobase catabolic process (GO:0006208)	6.05564068
7	central nervous system neuron axonogenesis (GO:0021955)	6.04485705
8	regulation of pigment cell differentiation (GO:0050932)	5.42754661
9	presynaptic membrane assembly (GO:0097105)	5.34925180
10	neuron recognition (GO:0008038)	5.03299910
11	nucleobase catabolic process (GO:0046113)	5.01148075
12	positive regulation of dendrite morphogenesis (GO:0050775)	4.97125326
13	spermatid nucleus differentiation (GO:0007289)	4.92197496
14	acrosome assembly (GO:0001675)	4.91089927
15	positive regulation of developmental pigmentation (GO:0048087)	4.58732881
16	presynaptic membrane organization (GO:0097090)	4.58624624
17	establishment of mitochondrion localization (GO:0051654)	4.57623159
18	mitochondrion transport along microtubule (GO:0047497)	4.52812726
19	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	4.52812726
20	cerebral cortex cell migration (GO:0021795)	4.45932206
21	axonal fasciculation (GO:0007413)	4.45579687
22	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	4.40120433
23	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	4.40120433
24	regulation of dendritic spine morphogenesis (GO:0061001)	4.34077607
25	opioid receptor signaling pathway (GO:0038003)	4.26047707
26	neurotransmitter-gated ion channel clustering (GO:0072578)	4.25581577
27	cell wall macromolecule catabolic process (GO:0016998)	4.24208068
28	negative regulation of norepinephrine secretion (GO:0010700)	4.12934008
29	sympathetic nervous system development (GO:0048485)	4.06962162
30	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	4.06047538
31	cardiac ventricle formation (GO:0003211)	3.95219558
32	cellular response to nitric oxide (GO:0071732)	3.95099111
33	neural tube formation (GO:0001841)	3.87582845
34	ectoderm development (GO:0007398)	3.81009295
35	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.79392738
36	olfactory bulb development (GO:0021772)	3.78671056
37	seminiferous tubule development (GO:0072520)	3.75060908
38	positive regulation of cardiac muscle cell differentiation (GO:2000727)	3.70201328
39	keratinocyte development (GO:0003334)	3.69771440
40	histone H2A acetylation (GO:0043968)	3.66435603
41	dentate gyrus development (GO:0021542)	3.63435762
42	cytoplasmic mRNA processing body assembly (GO:0033962)	3.61750000
43	cardiac chamber formation (GO:0003207)	3.61298723
44	hippocampus development (GO:0021766)	3.59367591
45	positive regulation of synapse assembly (GO:0051965)	3.51392753
46	cell wall macromolecule metabolic process (GO:0044036)	3.50988163
47	forebrain neuron differentiation (GO:0021879)	3.50859338
48	spinal cord development (GO:0021510)	3.41994574
49	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	3.41919886
50	regulation of dendritic spine development (GO:0060998)	3.41313126
51	secondary heart field specification (GO:0003139)	3.40479858
52	heart field specification (GO:0003128)	3.40479858
53	negative regulation of dendrite development (GO:2000171)	3.37456396
54	ventricular trabecula myocardium morphogenesis (GO:0003222)	3.33576463
55	negative regulation of astrocyte differentiation (GO:0048712)	3.31241627
56	telencephalon cell migration (GO:0022029)	3.24973072
57	glutamate receptor signaling pathway (GO:0007215)	3.23779560
58	negative regulation of axon extension (GO:0030517)	3.23223016
59	acrosome reaction (GO:0007340)	3.21312932
60	hindbrain development (GO:0030902)	3.15372560
61	response to nitric oxide (GO:0071731)	3.15213750
62	protein polyglutamylation (GO:0018095)	3.13167445
63	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.12222533
64	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.12222533
65	regulation of translation, ncRNA-mediated (GO:0045974)	3.12222533
66	glial cell proliferation (GO:0014009)	3.11069840
67	positive regulation of dendritic spine development (GO:0060999)	3.10794106
68	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.06665487
69	regulation of keratinocyte proliferation (GO:0010837)	3.05302555
70	forebrain cell migration (GO:0021885)	3.02139547
71	anterograde synaptic vesicle transport (GO:0048490)	3.00149781
72	positive regulation of protein homodimerization activity (GO:0090073)	2.99034973
73	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.95294649
74	meiotic chromosome segregation (GO:0045132)	2.94191488
75	peptidyl-lysine trimethylation (GO:0018023)	2.93324189
76	positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)	2.92993042
77	anatomical structure arrangement (GO:0048532)	2.91201133
78	positive regulation of amino acid transport (GO:0051957)	2.88985672
79	fucose catabolic process (GO:0019317)	2.88257483
80	L-fucose metabolic process (GO:0042354)	2.88257483
81	L-fucose catabolic process (GO:0042355)	2.88257483
82	negative regulation of catecholamine secretion (GO:0033604)	2.88188594
83	synaptic transmission, glutamatergic (GO:0035249)	2.87480707
84	reciprocal meiotic recombination (GO:0007131)	2.87089452
85	reciprocal DNA recombination (GO:0035825)	2.87089452
86	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.84182304
87	regulation of synapse assembly (GO:0051963)	2.80387342
88	peptidyl-glutamic acid modification (GO:0018200)	2.79517653
89	regulation of glutamate secretion (GO:0014048)	2.76757626
90	regulation of timing of cell differentiation (GO:0048505)	2.75974369
91	stress granule assembly (GO:0034063)	2.75391204
92	negative regulation of axonogenesis (GO:0050771)	2.75209664
93	regulation of inositol phosphate biosynthetic process (GO:0010919)	2.74061828
94	positive regulation of dendrite development (GO:1900006)	2.70811432
95	transmission of nerve impulse (GO:0019226)	2.67052527
96	neuron-neuron synaptic transmission (GO:0007270)	2.66390425
97	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.65982323
98	histone H3-K9 methylation (GO:0051567)	2.65887621
99	detection of light stimulus involved in visual perception (GO:0050908)	2.65789082
100	detection of light stimulus involved in sensory perception (GO:0050962)	2.65789082

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.11716961
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	4.68740485
3	GBX2_23144817_ChIP-Seq_PC3_Human	4.02738627
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.94935043
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.06663600
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.06656959
7	IGF1R_20145208_ChIP-Seq_DFB_Human	3.00446835
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.96802323
9	VDR_22108803_ChIP-Seq_LS180_Human	2.84102244
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.78233654
11	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.47988363
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.46333463
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.43649785
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.40485284
15	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.34742509
16	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.33728015
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.22133274
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.10219900
19	P300_19829295_ChIP-Seq_ESCs_Human	2.05283368
20	FUS_26573619_Chip-Seq_HEK293_Human	1.98505123
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.84725660
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.82745634
23	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.75926946
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.74514979
25	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.71446328
26	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.71446328
27	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.69208178
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.66654968
29	EWS_26573619_Chip-Seq_HEK293_Human	1.66525034
30	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.64784767
31	AR_21572438_ChIP-Seq_LNCaP_Human	1.64274920
32	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.62369613
33	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62290938
34	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.61612938
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.60616912
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.60616912
37	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.57141005
38	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56417812
39	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.52299079
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51851915
41	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.49888678
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.49482773
43	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.49071280
44	TCF4_23295773_ChIP-Seq_U87_Human	1.48602485
45	AR_25329375_ChIP-Seq_VCAP_Human	1.44687907
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44526252
47	ER_23166858_ChIP-Seq_MCF-7_Human	1.40016225
48	STAT3_23295773_ChIP-Seq_U87_Human	1.39901484
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38995936
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.38778418
51	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.36447410
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35100937
53	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.34576881
54	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.34528888
55	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.33629955
56	REST_21632747_ChIP-Seq_MESCs_Mouse	1.32155148
57	SOX9_26525672_Chip-Seq_HEART_Mouse	1.32057979
58	RNF2_27304074_Chip-Seq_NSC_Mouse	1.29213473
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26492210
60	TP53_18474530_ChIP-ChIP_U2OS_Human	1.26240071
61	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.21250098
62	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.20712069
63	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20305940
64	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.19734167
65	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.19679543
66	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.19535113
67	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.17644125
68	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.16084428
69	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.15811166
70	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14051599
71	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.10832834
72	DROSHA_22980978_ChIP-Seq_HELA_Human	1.10678277
73	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.09975667
74	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.09543169
75	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09118931
76	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.08601306
77	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08213173
78	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05767575
79	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.04603800
80	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.04538794
81	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.03775767
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03474173
83	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00725081
84	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00583030
85	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.00357485
86	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.99905488
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99171156
88	KDM2B_26808549_Chip-Seq_REH_Human	0.99040254
89	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.99019272
90	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98709216
91	TCF4_22108803_ChIP-Seq_LS180_Human	0.98168374
92	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.98114815
93	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.96528157
94	MYC_18940864_ChIP-ChIP_HL60_Human	0.95843913
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95603856
96	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94738296
97	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94738296
98	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.94729498
99	JUN_21703547_ChIP-Seq_K562_Human	0.93783184
100	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.93450521

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.65869465
2	MP0002735_abnormal_chemical_nociception	3.41843324
3	MP0000778_abnormal_nervous_system	3.18616938
4	MP0002837_dystrophic_cardiac_calcinosis	3.02421404
5	MP0003787_abnormal_imprinting	2.96188239
6	MP0002736_abnormal_nociception_after	2.85548536
7	MP0008789_abnormal_olfactory_epithelium	2.72518963
8	MP0000516_abnormal_urinary_system	2.63653962
9	MP0005367_renal/urinary_system_phenotyp	2.63653962
10	MP0001486_abnormal_startle_reflex	2.53318881
11	MP0004270_analgesia	2.48338069
12	MP0002234_abnormal_pharynx_morphology	2.45630969
13	MP0004885_abnormal_endolymph	2.27480975
14	MP0005394_taste/olfaction_phenotype	2.21623857
15	MP0005499_abnormal_olfactory_system	2.21623857
16	MP0003635_abnormal_synaptic_transmissio	2.08540366
17	MP0003121_genomic_imprinting	2.07553293
18	MP0003890_abnormal_embryonic-extraembry	2.07204574
19	MP0004859_abnormal_synaptic_plasticity	2.03906918
20	MP0001968_abnormal_touch/_nociception	1.99698973
21	MP0005174_abnormal_tail_pigmentation	1.99281501
22	MP0001529_abnormal_vocalization	1.97163519
23	MP0005551_abnormal_eye_electrophysiolog	1.97094694
24	MP0002751_abnormal_autonomic_nervous	1.93284638
25	MP0003718_maternal_effect	1.89612265
26	MP0008872_abnormal_physiological_respon	1.83133549
27	MP0000371_diluted_coat_color	1.79643957
28	MP0002734_abnormal_mechanical_nocicepti	1.72933483
29	MP0003880_abnormal_central_pattern	1.72688290
30	MP0008877_abnormal_DNA_methylation	1.68996011
31	MP0009046_muscle_twitch	1.68657054
32	MP0002063_abnormal_learning/memory/cond	1.66735661
33	MP0002067_abnormal_sensory_capabilities	1.55475453
34	MP0003942_abnormal_urinary_system	1.51753441
35	MP0003119_abnormal_digestive_system	1.51514849
36	MP0006292_abnormal_olfactory_placode	1.51046515
37	MP0000955_abnormal_spinal_cord	1.41591351
38	MP0002653_abnormal_ependyma_morphology	1.38329353
39	MP0004742_abnormal_vestibular_system	1.34226152
40	MP0004924_abnormal_behavior	1.32307128
41	MP0005386_behavior/neurological_phenoty	1.32307128
42	MP0003122_maternal_imprinting	1.31976836
43	MP0002733_abnormal_thermal_nociception	1.31806353
44	MP0001485_abnormal_pinna_reflex	1.31037318
45	MP0003221_abnormal_cardiomyocyte_apopto	1.30714903
46	MP0000049_abnormal_middle_ear	1.30060656
47	MP0002233_abnormal_nose_morphology	1.28079124
48	MP0002557_abnormal_social/conspecific_i	1.27813646
49	MP0009745_abnormal_behavioral_response	1.24727329
50	MP0003935_abnormal_craniofacial_develop	1.21914791
51	MP0002882_abnormal_neuron_morphology	1.18878308
52	MP0005395_other_phenotype	1.16827233
53	MP0005195_abnormal_posterior_eye	1.15454075
54	MP0003137_abnormal_impulse_conducting	1.14213714
55	MP0002572_abnormal_emotion/affect_behav	1.13753050
56	MP0002938_white_spotting	1.13435310
57	MP0002272_abnormal_nervous_system	1.13417311
58	MP0002184_abnormal_innervation	1.12661274
59	MP0003755_abnormal_palate_morphology	1.12419699
60	MP0002752_abnormal_somatic_nervous	1.05153892
61	MP0003861_abnormal_nervous_system	1.03648519
62	MP0002102_abnormal_ear_morphology	1.03501580
63	MP0001970_abnormal_pain_threshold	1.02355870
64	MP0001177_atelectasis	1.00528059
65	MP0005379_endocrine/exocrine_gland_phen	1.00017073
66	MP0002152_abnormal_brain_morphology	0.99928419
67	MP0002064_seizures	0.99029990
68	MP0004811_abnormal_neuron_physiology	0.98442172
69	MP0003633_abnormal_nervous_system	0.98179969
70	MP0009384_cardiac_valve_regurgitation	0.97199849
71	MP0001501_abnormal_sleep_pattern	0.97079224
72	MP0000534_abnormal_ureter_morphology	0.92645278
73	MP0003698_abnormal_male_reproductive	0.92376356
74	MP0002249_abnormal_larynx_morphology	0.91817470
75	MP0002066_abnormal_motor_capabilities/c	0.91089641
76	MP0001984_abnormal_olfaction	0.90673371
77	MP0001340_abnormal_eyelid_morphology	0.89357009
78	MP0006072_abnormal_retinal_apoptosis	0.88550198
79	MP0001440_abnormal_grooming_behavior	0.87016976
80	MP0001293_anophthalmia	0.85972182
81	MP0002095_abnormal_skin_pigmentation	0.85514235
82	MP0003631_nervous_system_phenotype	0.85380122
83	MP0003011_delayed_dark_adaptation	0.85259236
84	MP0001286_abnormal_eye_development	0.84927118
85	MP0003943_abnormal_hepatobiliary_system	0.84425299
86	MP0000647_abnormal_sebaceous_gland	0.84052748
87	MP0005257_abnormal_intraocular_pressure	0.83310754
88	MP0002168_other_aberrant_phenotype	0.81422485
89	MP0005253_abnormal_eye_physiology	0.79780283
90	MP0002069_abnormal_eating/drinking_beha	0.77595706
91	MP0000631_abnormal_neuroendocrine_gland	0.77531255
92	MP0000372_irregular_coat_pigmentation	0.76719541
93	MP0002098_abnormal_vibrissa_morphology	0.76089433
94	MP0004085_abnormal_heartbeat	0.75514150
95	MP0002210_abnormal_sex_determination	0.73493633
96	MP0000762_abnormal_tongue_morphology	0.69496372
97	MP0004142_abnormal_muscle_tone	0.68999217
98	MP0001929_abnormal_gametogenesis	0.68497239
99	MP0003385_abnormal_body_wall	0.66769982
100	MP0000026_abnormal_inner_ear	0.65893885

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Action tremor (HP:0002345)	5.44930895
2	Progressive cerebellar ataxia (HP:0002073)	5.08397571
3	Skull defect (HP:0001362)	4.96828893
4	Bilateral microphthalmos (HP:0007633)	4.09450632
5	Drooling (HP:0002307)	3.97911311
6	Morphological abnormality of the middle ear (HP:0008609)	3.93141993
7	Excessive salivation (HP:0003781)	3.72660905
8	Absent speech (HP:0001344)	3.67484285
9	Joint hemorrhage (HP:0005261)	3.63911204
10	Absent eyebrow (HP:0002223)	3.53480709
11	Prolonged partial thromboplastin time (HP:0003645)	3.46093727
12	Aplasia/Hypoplasia of the sternum (HP:0006714)	3.42447536
13	Cupped ear (HP:0000378)	3.39411201
14	Hyperventilation (HP:0002883)	3.38951765
15	Midline defect of the nose (HP:0004122)	3.28558833
16	Genital tract atresia (HP:0001827)	3.28448752
17	Vaginal atresia (HP:0000148)	3.23737173
18	Abnormality of the pubic bones (HP:0003172)	3.20978716
19	Retinal dysplasia (HP:0007973)	3.20636968
20	Hypochromic microcytic anemia (HP:0004840)	3.18707464
21	Protruding tongue (HP:0010808)	3.09422006
22	Broad-based gait (HP:0002136)	3.08227969
23	Abnormality of the intrinsic pathway (HP:0010989)	3.03457024
24	Rectovaginal fistula (HP:0000143)	3.00110306
25	Rectal fistula (HP:0100590)	3.00110306
26	Fair hair (HP:0002286)	2.92731695
27	Chronic hepatic failure (HP:0100626)	2.92304002
28	Genetic anticipation (HP:0003743)	2.91446916
29	Bifid tongue (HP:0010297)	2.91095223
30	Long nose (HP:0003189)	2.87835199
31	Absent eyelashes (HP:0000561)	2.83664270
32	Poor eye contact (HP:0000817)	2.78531548
33	Conical tooth (HP:0000698)	2.75888194
34	Abnormality of the nasolacrimal system (HP:0000614)	2.71668421
35	Renal hypoplasia (HP:0000089)	2.67974342
36	Gaze-evoked nystagmus (HP:0000640)	2.65863508
37	Delusions (HP:0000746)	2.65611679
38	Scrotal hypoplasia (HP:0000046)	2.61310371
39	Epileptic encephalopathy (HP:0200134)	2.54862129
40	Adactyly (HP:0009776)	2.52081417
41	Cutaneous finger syndactyly (HP:0010554)	2.51514159
42	Anophthalmia (HP:0000528)	2.50387854
43	Abnormal social behavior (HP:0012433)	2.50193749
44	Impaired social interactions (HP:0000735)	2.50193749
45	Medial flaring of the eyebrow (HP:0010747)	2.50026793
46	Intestinal fistula (HP:0100819)	2.49686292
47	Febrile seizures (HP:0002373)	2.46358659
48	Hypoproteinemia (HP:0003075)	2.45705984
49	Amyotrophic lateral sclerosis (HP:0007354)	2.44986376
50	Myokymia (HP:0002411)	2.44841969
51	Tented upper lip vermilion (HP:0010804)	2.43883286
52	Smooth philtrum (HP:0000319)	2.42815968
53	Submucous cleft hard palate (HP:0000176)	2.40054119
54	Bicornuate uterus (HP:0000813)	2.35498486
55	Vaginal fistula (HP:0004320)	2.32966412
56	Abnormal hair whorl (HP:0010721)	2.28698683
57	Myelomeningocele (HP:0002475)	2.27211134
58	Abnormal lung lobation (HP:0002101)	2.23389625
59	Focal seizures (HP:0007359)	2.21810494
60	Clitoromegaly (HP:0000057)	2.19664615
61	Generalized hypopigmentation of hair (HP:0011358)	2.17654148
62	Hypoplastic pelvis (HP:0008839)	2.16804614
63	Exotropia (HP:0000577)	2.15533193
64	Choanal stenosis (HP:0000452)	2.15434980
65	Dysdiadochokinesis (HP:0002075)	2.14361535
66	Septate vagina (HP:0001153)	2.14103702
67	Abnormality of salivation (HP:0100755)	2.08802338
68	Nephronophthisis (HP:0000090)	2.08443711
69	Gait imbalance (HP:0002141)	2.08342922
70	Cutaneous syndactyly (HP:0012725)	2.06364253
71	Facial cleft (HP:0002006)	2.06336595
72	Biliary tract neoplasm (HP:0100574)	2.02790248
73	Widely spaced teeth (HP:0000687)	2.02719860
74	Absent hair (HP:0002298)	2.02309953
75	Absent/shortened dynein arms (HP:0200106)	1.99147973
76	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.99147973
77	Focal motor seizures (HP:0011153)	1.97145837
78	Oligodontia (HP:0000677)	1.95912971
79	Preaxial foot polydactyly (HP:0001841)	1.95080061
80	Abnormality of B cell number (HP:0010975)	1.94956686
81	Congenital primary aphakia (HP:0007707)	1.94113640
82	Acute lymphatic leukemia (HP:0006721)	1.92774438
83	Inability to walk (HP:0002540)	1.91689826
84	Dyskinesia (HP:0100660)	1.89916696
85	Sensorimotor neuropathy (HP:0007141)	1.89559394
86	Sclerocornea (HP:0000647)	1.89075851
87	Large earlobe (HP:0009748)	1.87662309
88	Pancreatic cysts (HP:0001737)	1.86461111
89	B lymphocytopenia (HP:0010976)	1.86316001
90	Micropenis (HP:0000054)	1.85877424
91	Hypoplastic nipples (HP:0002557)	1.85340150
92	Intellectual disability, severe (HP:0010864)	1.84760181
93	Rhabdomyosarcoma (HP:0002859)	1.83825230
94	Bony spicule pigmentary retinopathy (HP:0007737)	1.83519375
95	Dialeptic seizures (HP:0011146)	1.81208266
96	Decreased testicular size (HP:0008734)	1.81062774
97	Molar tooth sign on MRI (HP:0002419)	1.80419804
98	Abnormality of midbrain morphology (HP:0002418)	1.80419804
99	Abnormality of the labia minora (HP:0012880)	1.79688232
100	Lymphangioma (HP:0100764)	1.79455885

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	5.24705977
2	FRK	5.09790592
3	MAP3K4	4.04819116
4	EIF2AK3	3.97198141
5	MAP2K7	3.96160357
6	MAP3K6	3.94296480
7	MARK1	3.22614700
8	EPHA4	2.99536543
9	TRIM28	2.68750798
10	CASK	2.14150300
11	PLK4	2.08970901
12	MAPK13	2.07623311
13	CCNB1	1.88612725
14	MAP2K4	1.83169956
15	BCR	1.80279127
16	MKNK2	1.75609753
17	PKN1	1.73781943
18	BMPR1B	1.72284286
19	EPHA3	1.69719698
20	DYRK2	1.53475433
21	ACVR1B	1.45125433
22	KSR1	1.34376261
23	SGK2	1.29598023
24	MAP3K10	1.25305244
25	PIK3CA	1.24904648
26	BRD4	1.21207965
27	WNK3	1.20302861
28	PAK3	1.19367784
29	MKNK1	1.15688356
30	SIK2	1.12729823
31	ZAK	1.12162176
32	CSNK1G1	1.07890633
33	YES1	1.07678281
34	NLK	1.04770910
35	OXSR1	0.99010562
36	MAP3K5	0.98931357
37	PNCK	0.97292446
38	SRPK1	0.93997766
39	MAP4K2	0.92914181
40	DYRK1A	0.89058281
41	FGFR2	0.88939636
42	EPHB2	0.86334094
43	VRK1	0.78742014
44	SGK494	0.77770321
45	SGK223	0.77770321
46	ADRBK2	0.74248477
47	CDK19	0.71657841
48	SIK3	0.71345220
49	PRKCG	0.70787820
50	ERBB3	0.67208253
51	TGFBR1	0.66718410
52	CDK5	0.66694702
53	PLK3	0.66199672
54	ADRBK1	0.61966705
55	ROCK1	0.59729952
56	INSRR	0.59699798
57	GRK1	0.59006402
58	NTRK2	0.54292555
59	SGK3	0.51669724
60	PHKG2	0.51314274
61	PHKG1	0.51314274
62	MAPK8	0.48775498
63	PLK2	0.46564990
64	ERBB2	0.45948015
65	CDK18	0.42837840
66	CSNK1A1	0.42284774
67	PRKCE	0.42177732
68	GSK3B	0.40105149
69	STK39	0.39481678
70	WNK4	0.39153287
71	CAMK2B	0.38748623
72	PAK6	0.38574737
73	GSK3A	0.38517171
74	MAPK7	0.37682050
75	PRKCZ	0.37415796
76	FGFR3	0.35904049
77	CDK1	0.34068611
78	DAPK2	0.33671775
79	CDK15	0.33271756
80	STK11	0.33203817
81	FER	0.32302479
82	TAOK3	0.31990676
83	CSNK1D	0.31706109
84	RPS6KB1	0.31537948
85	CSNK1G2	0.31399672
86	RET	0.30928679
87	CAMK1	0.30194064
88	DYRK3	0.29182571
89	MINK1	0.27535153
90	IRAK2	0.25741302
91	CDK11A	0.25606824
92	CAMK4	0.24686255
93	RPS6KA3	0.23451305
94	PLK1	0.23402485
95	LATS1	0.23104532
96	PRKACB	0.22536196
97	PKN2	0.22329427
98	CAMK2A	0.22239087
99	RPS6KA4	0.21460874
100	MAPK4	0.19699645

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	5.23621808
2	Steroid biosynthesis_Homo sapiens_hsa00100	3.07123423
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.00531199
4	Nicotine addiction_Homo sapiens_hsa05033	2.79445426
5	Phototransduction_Homo sapiens_hsa04744	2.61585807
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.43351820
7	Glutamatergic synapse_Homo sapiens_hsa04724	2.24418494
8	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.23900744
9	Butanoate metabolism_Homo sapiens_hsa00650	2.20313447
10	Circadian entrainment_Homo sapiens_hsa04713	2.16828548
11	Taste transduction_Homo sapiens_hsa04742	2.16240132
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.91327903
13	Long-term depression_Homo sapiens_hsa04730	1.83112656
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.83092388
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.81472647
16	Dopaminergic synapse_Homo sapiens_hsa04728	1.79835501
17	Cocaine addiction_Homo sapiens_hsa05030	1.76905439
18	GABAergic synapse_Homo sapiens_hsa04727	1.76362574
19	Morphine addiction_Homo sapiens_hsa05032	1.76306306
20	Axon guidance_Homo sapiens_hsa04360	1.59738696
21	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.49982664
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.48172236
23	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.33779572
24	Amphetamine addiction_Homo sapiens_hsa05031	1.33060269
25	Renin secretion_Homo sapiens_hsa04924	1.32177008
26	RNA polymerase_Homo sapiens_hsa03020	1.30893488
27	Mismatch repair_Homo sapiens_hsa03430	1.29775280
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23815469
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.21125261
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.20121749
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17494186
32	Salivary secretion_Homo sapiens_hsa04970	1.13818062
33	Olfactory transduction_Homo sapiens_hsa04740	1.10975551
34	Gastric acid secretion_Homo sapiens_hsa04971	1.09740835
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.08202545
36	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.02978082
37	Insulin secretion_Homo sapiens_hsa04911	0.96650425
38	Gap junction_Homo sapiens_hsa04540	0.96428026
39	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.94712775
40	Lysine degradation_Homo sapiens_hsa00310	0.94213907
41	Caffeine metabolism_Homo sapiens_hsa00232	0.92820881
42	Homologous recombination_Homo sapiens_hsa03440	0.88267426
43	cAMP signaling pathway_Homo sapiens_hsa04024	0.88249785
44	Serotonergic synapse_Homo sapiens_hsa04726	0.87115081
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.86314010
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.82788775
47	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.81492309
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.81166321
49	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.80872946
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.80039447
51	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.77755444
52	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.74408711
53	Retinol metabolism_Homo sapiens_hsa00830	0.74101648
54	Basal transcription factors_Homo sapiens_hsa03022	0.73310657
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73247110
56	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72780482
57	Cholinergic synapse_Homo sapiens_hsa04725	0.71928312
58	Oocyte meiosis_Homo sapiens_hsa04114	0.70922819
59	Complement and coagulation cascades_Homo sapiens_hsa04610	0.69834410
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69188500
61	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.67989003
62	Sphingolipid metabolism_Homo sapiens_hsa00600	0.64168893
63	Long-term potentiation_Homo sapiens_hsa04720	0.63925455
64	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.62621958
65	Circadian rhythm_Homo sapiens_hsa04710	0.60587835
66	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.60474489
67	RNA degradation_Homo sapiens_hsa03018	0.58853920
68	Calcium signaling pathway_Homo sapiens_hsa04020	0.57983766
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.57564495
70	mRNA surveillance pathway_Homo sapiens_hsa03015	0.53119901
71	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.52477714
72	Wnt signaling pathway_Homo sapiens_hsa04310	0.52312981
73	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52245615
74	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.51950103
75	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.50250178
76	Alcoholism_Homo sapiens_hsa05034	0.49391434
77	Peroxisome_Homo sapiens_hsa04146	0.49137626
78	Hippo signaling pathway_Homo sapiens_hsa04390	0.48018521
79	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.48006733
80	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.47495176
81	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.47352730
82	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.46888324
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.46830725
84	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.44101537
85	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.42580152
86	Melanogenesis_Homo sapiens_hsa04916	0.42468287
87	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.41570670
88	Tight junction_Homo sapiens_hsa04530	0.40155643
89	RNA transport_Homo sapiens_hsa03013	0.39885836
90	Pertussis_Homo sapiens_hsa05133	0.38759064
91	Nitrogen metabolism_Homo sapiens_hsa00910	0.37762003
92	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37666433
93	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.33879407
94	Ras signaling pathway_Homo sapiens_hsa04014	0.33800823
95	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.33273369
96	Propanoate metabolism_Homo sapiens_hsa00640	0.31637190
97	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.30975746
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.30337252
99	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.28370024
100	Choline metabolism in cancer_Homo sapiens_hsa05231	0.27836086

OSBPL9P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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