OSCAR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drinking behavior (GO:0042756)6.09659436
2vitamin transmembrane transport (GO:0035461)5.96297326
3neutrophil activation involved in immune response (GO:0002283)5.76422836
4response to peptidoglycan (GO:0032494)5.61795733
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.47840077
6protein localization to synapse (GO:0035418)5.38438673
7negative regulation of cell killing (GO:0031342)5.23900464
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.23900464
9positive regulation by symbiont of host defense response (GO:0052509)5.23745908
10modulation by symbiont of host defense response (GO:0052031)5.23745908
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.23745908
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.23745908
13positive regulation by organism of defense response of other organism involved in symbiotic interact5.23745908
14modulation by symbiont of host immune response (GO:0052553)5.23745908
15negative regulation of interleukin-12 production (GO:0032695)5.22680153
16positive regulation of gamma-delta T cell activation (GO:0046645)5.17877480
17positive regulation of vascular permeability (GO:0043117)5.07757964
18regulation of feeding behavior (GO:0060259)5.02804465
19macrophage activation involved in immune response (GO:0002281)4.92175094
20detection of other organism (GO:0098543)4.75197082
21pyrimidine-containing compound transmembrane transport (GO:0072531)4.60051189
22detection of bacterium (GO:0016045)4.57916443
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.54911118
24negative regulation of digestive system process (GO:0060457)4.46408790
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.42228560
26negative regulation of response to food (GO:0032096)4.41139114
27negative regulation of appetite (GO:0032099)4.41139114
28positive regulation of fibroblast migration (GO:0010763)4.40368927
29immunoglobulin mediated immune response (GO:0016064)4.39352602
30vocalization behavior (GO:0071625)4.38123248
31negative regulation of synaptic transmission, GABAergic (GO:0032229)4.28632782
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.25823291
33leukocyte aggregation (GO:0070486)4.20678939
34cellular extravasation (GO:0045123)4.17280745
35opioid receptor signaling pathway (GO:0038003)4.16265443
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.14564187
37ionotropic glutamate receptor signaling pathway (GO:0035235)4.14225497
38antigen processing and presentation of endogenous antigen (GO:0019883)4.09681594
39glutamate secretion (GO:0014047)4.07171790
40neurotransmitter-gated ion channel clustering (GO:0072578)4.06542876
41neutrophil activation (GO:0042119)4.04460688
42detection of external biotic stimulus (GO:0098581)4.04449848
43antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.03977360
44negative regulation of amino acid transport (GO:0051956)4.03079284
45granulocyte activation (GO:0036230)4.01907581
46regulation of mast cell degranulation (GO:0043304)3.93932320
47detection of molecule of bacterial origin (GO:0032490)3.93398653
48respiratory burst (GO:0045730)3.93046618
49glutamate receptor signaling pathway (GO:0007215)3.90432734
50regulation of glutamate secretion (GO:0014048)3.89922809
51startle response (GO:0001964)3.86822907
52long-chain fatty acid biosynthetic process (GO:0042759)3.80011706
53synaptic transmission, glutamatergic (GO:0035249)3.76529956
54G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.72810033
55regulation of interferon-beta biosynthetic process (GO:0045357)3.72499325
56leukocyte migration involved in inflammatory response (GO:0002523)3.72470576
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.70963264
58negative regulation of neurotransmitter secretion (GO:0046929)3.70327343
59lipopolysaccharide-mediated signaling pathway (GO:0031663)3.69601194
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.68035609
61myeloid cell activation involved in immune response (GO:0002275)3.67488650
62neuron-neuron synaptic transmission (GO:0007270)3.67177188
63regulation of gamma-delta T cell activation (GO:0046643)3.64412169
64positive regulation of mast cell activation (GO:0033005)3.64263340
65gamma-aminobutyric acid signaling pathway (GO:0007214)3.63706110
66regulation of mast cell activation involved in immune response (GO:0033006)3.63674093
67behavioral response to cocaine (GO:0048148)3.61761475
68regulation of B cell receptor signaling pathway (GO:0050855)3.60521495
69cerebellar granule cell differentiation (GO:0021707)3.60089005
70detection of biotic stimulus (GO:0009595)3.59178199
71response to host immune response (GO:0052572)3.57984826
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.57984826
73macrophage activation (GO:0042116)3.57709046
74regulation of myeloid leukocyte mediated immunity (GO:0002886)3.56117100
75response to muramyl dipeptide (GO:0032495)3.53481696
76negative regulation of response to extracellular stimulus (GO:0032105)3.53047345
77negative regulation of response to nutrient levels (GO:0032108)3.53047345
78regulation of leukocyte degranulation (GO:0043300)3.49921637
79microglial cell activation (GO:0001774)3.49566037
80cellular response to type I interferon (GO:0071357)3.49064208
81type I interferon signaling pathway (GO:0060337)3.49064208
82long-term synaptic potentiation (GO:0060291)3.48756694
83regulation of phospholipase A2 activity (GO:0032429)3.47100266
84negative regulation of lymphocyte mediated immunity (GO:0002707)3.45608953
85response to type I interferon (GO:0034340)3.44876437
86negative regulation of cytokine production involved in immune response (GO:0002719)3.43058290
87regulation of glutamate receptor signaling pathway (GO:1900449)3.41458300
88long-term memory (GO:0007616)3.41189872
89defense response to protozoan (GO:0042832)3.40755980
90regulation of mast cell activation (GO:0033003)3.40290295
91positive regulation of mast cell degranulation (GO:0043306)3.39926328
92positive regulation of mast cell activation involved in immune response (GO:0033008)3.39926328
93presynaptic membrane assembly (GO:0097105)3.39460537
94interferon-gamma-mediated signaling pathway (GO:0060333)3.38990745
95germinal center formation (GO:0002467)3.38106006
96regulation of synaptic transmission, glutamatergic (GO:0051966)3.36485019
97B cell mediated immunity (GO:0019724)3.34864573
98positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.33734551
99regulation of synapse maturation (GO:0090128)3.33047542
100regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.32899704
101positive regulation of synapse maturation (GO:0090129)3.32768363
102regulation of T-helper 2 cell differentiation (GO:0045628)3.31862640
103synaptic vesicle exocytosis (GO:0016079)3.27326134
104regulation of neuronal synaptic plasticity (GO:0048168)3.26046769
105regulation of dendritic cell antigen processing and presentation (GO:0002604)3.24500549
106lung-associated mesenchyme development (GO:0060484)3.23914614
107regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.23822873
108response to host (GO:0075136)3.22868762
109response to host defenses (GO:0052200)3.22868762
110response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.22868762
111regulation of synaptic vesicle exocytosis (GO:2000300)3.22621724
112negative regulation of leukocyte mediated immunity (GO:0002704)3.21924619
113regulation of long-term neuronal synaptic plasticity (GO:0048169)3.21752161
114negative regulation of erythrocyte differentiation (GO:0045647)3.21411001
115negative regulation of T cell mediated immunity (GO:0002710)3.20564479
116response to protozoan (GO:0001562)3.19325500
117regulation of T cell tolerance induction (GO:0002664)3.17441593
118regulation of synaptic vesicle transport (GO:1902803)3.17389440
119presynaptic membrane organization (GO:0097090)3.16316615
120grooming behavior (GO:0007625)3.15569719
121proline transport (GO:0015824)3.13513408
122serotonin receptor signaling pathway (GO:0007210)3.12929082
123negative regulation of neurotransmitter transport (GO:0051589)3.10546631
124production of molecular mediator involved in inflammatory response (GO:0002532)3.09997205
125neuron cell-cell adhesion (GO:0007158)3.09898172
126positive regulation of muscle cell apoptotic process (GO:0010661)3.09651381
127regulation of interferon-alpha production (GO:0032647)3.09039474
128neutrophil mediated immunity (GO:0002446)3.08240810
129regulation of antigen processing and presentation (GO:0002577)3.08125837
130regulation of synaptic plasticity (GO:0048167)3.07615193
131negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.06129293
132positive regulation of antigen processing and presentation (GO:0002579)3.06051948
133negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05872836
134positive regulation of cellular amide metabolic process (GO:0034250)3.05497424
135regulation of tolerance induction (GO:0002643)3.04587813
136myeloid dendritic cell differentiation (GO:0043011)3.03691394
137positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.02915314
138regulation of dopamine secretion (GO:0014059)3.00139591
139transferrin transport (GO:0033572)2.99975882
140T-helper 1 type immune response (GO:0042088)2.99652350
141neuronal action potential propagation (GO:0019227)2.98590082
142positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.98087073
143rRNA modification (GO:0000154)2.96479034
144positive regulation of interferon-alpha production (GO:0032727)2.96475233
145positive regulation of type 2 immune response (GO:0002830)2.96369386
146neutrophil chemotaxis (GO:0030593)2.96022446
147leukocyte degranulation (GO:0043299)2.95978896
148glycerophospholipid catabolic process (GO:0046475)2.95743447
149activation of protein kinase A activity (GO:0034199)2.95204238
150regulation of excitatory postsynaptic membrane potential (GO:0060079)2.95155358
151regulation of appetite (GO:0032098)2.94965799
152negative regulation of interleukin-6 production (GO:0032715)2.94816473
153positive regulation of amino acid transport (GO:0051957)2.94285806
154regulation of regulated secretory pathway (GO:1903305)2.94171172
155myeloid leukocyte activation (GO:0002274)2.93234369
156NIK/NF-kappaB signaling (GO:0038061)2.92828501
157myeloid dendritic cell activation (GO:0001773)2.90665438
158auditory behavior (GO:0031223)2.90173762
159positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.89507040
160cilium or flagellum-dependent cell motility (GO:0001539)2.88612481
161neutrophil migration (GO:1990266)2.88190662
162response to histamine (GO:0034776)2.87773340
163response to redox state (GO:0051775)2.87344197
164learning (GO:0007612)2.87201148
165negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.85909286
166positive regulation of leukocyte degranulation (GO:0043302)2.85179858
167negative regulation of innate immune response (GO:0045824)2.83199747
168positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.82953859
169positive regulation of membrane potential (GO:0045838)2.81521337
170glutamine family amino acid biosynthetic process (GO:0009084)2.81147149
171mechanosensory behavior (GO:0007638)2.80029625
172regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.79935694
173response to pain (GO:0048265)2.79838137
174negative regulation of macroautophagy (GO:0016242)2.79410937
175regulation of type 2 immune response (GO:0002828)2.79374934
176synaptic vesicle maturation (GO:0016188)2.76744847
177positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.75996713
178neurotransmitter secretion (GO:0007269)2.75712646
179ferric iron transport (GO:0015682)2.75401693
180trivalent inorganic cation transport (GO:0072512)2.75401693
181negative regulation of production of molecular mediator of immune response (GO:0002701)2.74968643
182serotonin metabolic process (GO:0042428)2.74591869
183regulation of response to food (GO:0032095)2.74343520
184regulation of neurotransmitter secretion (GO:0046928)2.74097924
185transmission of nerve impulse (GO:0019226)2.73650369
186amino sugar catabolic process (GO:0046348)2.73382839
187detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73302762
188membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72758515
189positive regulation of B cell differentiation (GO:0045579)2.71687972
190regulation of postsynaptic membrane potential (GO:0060078)2.71087717
191regulation of gamma-delta T cell differentiation (GO:0045586)2.70823296
192positive regulation of toll-like receptor signaling pathway (GO:0034123)2.70445486
193dendrite development (GO:0016358)2.68635522
194postsynaptic membrane organization (GO:0001941)2.64022840
195membrane depolarization (GO:0051899)2.62740410
196alditol metabolic process (GO:0019400)2.62078684
197proline biosynthetic process (GO:0006561)2.60534449
198neurofilament cytoskeleton organization (GO:0060052)2.59398077
199rRNA methylation (GO:0031167)2.59011473
200regulation of synaptic transmission (GO:0050804)2.58780553

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.02632253
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.54790447
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.75924067
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.73085774
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.58094005
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.52906753
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.50580063
8GBX2_23144817_ChIP-Seq_PC3_Human3.37309304
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.16936615
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10640631
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.07664333
12VDR_21846776_ChIP-Seq_THP-1_Human2.84526904
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.80697088
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.76669024
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.75535435
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75321065
17VDR_24763502_ChIP-Seq_THP-1_Human2.74109783
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66814575
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.62558781
20* SPI1_23547873_ChIP-Seq_NB4_Human2.61477256
21REST_21632747_ChIP-Seq_MESCs_Mouse2.58677943
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56121746
23SPI1_23127762_ChIP-Seq_K562_Human2.54451480
24* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.47523629
25JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45719250
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.42963268
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.41556666
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36851177
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34171428
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34036827
31CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33764790
32FUS_26573619_Chip-Seq_HEK293_Human2.33645503
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.29458270
34* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.28935874
35EED_16625203_ChIP-ChIP_MESCs_Mouse2.28457818
36EGR1_19374776_ChIP-ChIP_THP-1_Human2.25962641
37ZNF274_21170338_ChIP-Seq_K562_Hela2.22632849
38BRD4_27068464_Chip-Seq_AML-cells_Mouse2.19187570
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18376523
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16197240
41EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13990892
42RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13990892
43RUNX1_22412390_ChIP-Seq_EML_Mouse2.13767450
44JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09174854
45SCL_19346495_ChIP-Seq_HPC-7_Human2.08183056
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07326015
47MAF_26560356_Chip-Seq_TH1_Human2.07017824
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.06159024
49RUNX_20019798_ChIP-Seq_JUKART_Human2.02117663
50EZH2_27304074_Chip-Seq_ESCs_Mouse2.01741558
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.99793814
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99622723
53VDR_24787735_ChIP-Seq_THP-1_Human1.99249936
54DROSHA_22980978_ChIP-Seq_HELA_Human1.96641307
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95214339
56TAF15_26573619_Chip-Seq_HEK293_Human1.94538072
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.90388847
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89391427
59* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.88503859
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.88226782
61SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84598469
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84321827
63MYB_26560356_Chip-Seq_TH2_Human1.83245709
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82718971
65UTX_26944678_Chip-Seq_JUKART_Human1.81875270
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81264316
67MYC_22102868_ChIP-Seq_BL_Human1.78446612
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76139713
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.75998009
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.74740979
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74573038
72* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.73116452
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71895082
74TCF7_22412390_ChIP-Seq_EML_Mouse1.71850709
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70543727
76RARB_27405468_Chip-Seq_BRAIN_Mouse1.69024070
77* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.64664301
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63908312
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.63448883
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63280804
81KDM2B_26808549_Chip-Seq_DND41_Human1.60292426
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59964868
83SMAD4_21799915_ChIP-Seq_A2780_Human1.58236587
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.57220300
85LXR_22292898_ChIP-Seq_THP-1_Human1.55971742
86P300_19829295_ChIP-Seq_ESCs_Human1.55364568
87MAF_26560356_Chip-Seq_TH2_Human1.53913894
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53605007
89MYB_26560356_Chip-Seq_TH1_Human1.53313974
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.51907052
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51801901
92* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49654290
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.49051338
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48683606
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.48198408
96* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45050154
97IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43592551
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43180980
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41767515
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41519876
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41500328
102STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41337863
103RNF2_27304074_Chip-Seq_ESCs_Mouse1.40531813
104* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40180096
105PU_27001747_Chip-Seq_BMDM_Mouse1.38411867
106CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37029864
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.36544645
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35787671
109AR_25329375_ChIP-Seq_VCAP_Human1.34015542
110STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33537741
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32896162
112* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32447022
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30935355
114* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30786194
115AHR_22903824_ChIP-Seq_MCF-7_Human1.30768388
116PIAS1_25552417_ChIP-Seq_VCAP_Human1.30521873
117GATA3_27048872_Chip-Seq_THYMUS_Human1.30432501
118CBX2_27304074_Chip-Seq_ESCs_Mouse1.27791425
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25091773
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24792563
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24638914
122GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23899884
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20776313
124GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19796346
125ER_23166858_ChIP-Seq_MCF-7_Human1.19701619
126IRF1_19129219_ChIP-ChIP_H3396_Human1.17974319
127GATA1_19941826_ChIP-Seq_K562_Human1.17928053
128* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17502178
129SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17341318
130STAT3_23295773_ChIP-Seq_U87_Human1.17181637
131ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15797555
132GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15765871
133PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15672547
134* BCL6_27268052_Chip-Seq_Bcells_Human1.14500569
135POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14246557
136KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13682026
137TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13576874
138SALL1_21062744_ChIP-ChIP_HESCs_Human1.12922635
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12419141
140BCOR_27268052_Chip-Seq_Bcells_Human1.11936461
141EWS_26573619_Chip-Seq_HEK293_Human1.11926534
142AR_21572438_ChIP-Seq_LNCaP_Human1.11724780
143RNF2_27304074_Chip-Seq_NSC_Mouse1.11304892
144NANOG_18555785_Chip-Seq_ESCs_Mouse1.11046552
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10999154
146VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10030137
147PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09091588
148TCF4_23295773_ChIP-Seq_U87_Human1.07567280
149VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07470685
150NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07130441
151GATA3_26560356_Chip-Seq_TH2_Human1.06049238
152CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05292390
153* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05256843
154GATA1_22025678_ChIP-Seq_K562_Human1.05215787
155SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04867949
156SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04333791
157EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03966820
158GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03421543
159ARNT_22903824_ChIP-Seq_MCF-7_Human1.03017546
160NFE2_27457419_Chip-Seq_LIVER_Mouse1.02569976
161SOX2_21211035_ChIP-Seq_LN229_Gbm1.02115400
162GATA2_21666600_ChIP-Seq_HMVEC_Human1.00653635
163ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00645222
164UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00620650
165P53_22387025_ChIP-Seq_ESCs_Mouse0.98531426
166TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98019814
167KDM2B_26808549_Chip-Seq_JURKAT_Human0.97017636
168CTCF_27219007_Chip-Seq_Bcells_Human0.97015928
169NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96181804
170E2F1_18555785_Chip-Seq_ESCs_Mouse0.96057809
171P300_18555785_Chip-Seq_ESCs_Mouse0.96041744
172TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95802407
173ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95715035
174GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94657932
175STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94402890
176OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94243983
177PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93823972
178CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93136139
179RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93073713
180RUNX2_22187159_ChIP-Seq_PCA_Human0.90025431
181SOX2_18555785_Chip-Seq_ESCs_Mouse0.89937569
182ELF1_20517297_ChIP-Seq_JURKAT_Human0.89908205
183CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89792775
184AR_19668381_ChIP-Seq_PC3_Human0.89763546
185NMYC_18555785_Chip-Seq_ESCs_Mouse0.89729768
186CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89054804
187EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.88859618
188STAT1_20625510_ChIP-Seq_HELA_Human0.88461127
189NCOR1_26117541_ChIP-Seq_K562_Human0.88424473
190MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88073094
191SPI1_20517297_ChIP-Seq_HL60_Human0.85724114
192TFEB_21752829_ChIP-Seq_HELA_Human0.84837434
193GATA2_19941826_ChIP-Seq_K562_Human0.83794243
194SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.81852788
195RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81446077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.63534288
2MP0003303_peritoneal_inflammation4.41901009
3MP0004859_abnormal_synaptic_plasticity4.34386508
4MP0003724_increased_susceptibility_to4.23823612
5MP0003436_decreased_susceptibility_to4.19279442
6MP0001835_abnormal_antigen_presentation3.53862521
7MP0006082_CNS_inflammation3.40279734
8MP0003880_abnormal_central_pattern3.28945290
9MP0002419_abnormal_innate_immunity3.24037533
10MP0003878_abnormal_ear_physiology3.22868363
11MP0005377_hearing/vestibular/ear_phenot3.22868363
12MP0009785_altered_susceptibility_to3.21460684
13MP0002064_seizures3.00015208
14MP0009745_abnormal_behavioral_response2.99568777
15MP0002148_abnormal_hypersensitivity_rea2.95142032
16MP0003635_abnormal_synaptic_transmissio2.91363115
17MP0005025_abnormal_response_to2.90956262
18MP0005671_abnormal_response_to2.87011201
19MP0005387_immune_system_phenotype2.85543953
20MP0001790_abnormal_immune_system2.85543953
21MP0005000_abnormal_immune_tolerance2.84562983
22MP0009046_muscle_twitch2.84032590
23MP0001440_abnormal_grooming_behavior2.83178857
24MP0002735_abnormal_chemical_nociception2.81775149
25MP0005058_abnormal_lysosome_morphology2.81193000
26MP0005171_absent_coat_pigmentation2.67964457
27MP0002736_abnormal_nociception_after2.67339460
28MP0001486_abnormal_startle_reflex2.64594329
29MP0001188_hyperpigmentation2.59297487
30MP0002063_abnormal_learning/memory/cond2.57936228
31MP0004270_analgesia2.57488443
32MP0002572_abnormal_emotion/affect_behav2.56700382
33MP0003300_gastrointestinal_ulcer2.53151137
34MP0001800_abnormal_humoral_immune2.52101962
35MP0001968_abnormal_touch/_nociception2.48817933
36MP0002452_abnormal_antigen_presenting2.44633662
37MP0002723_abnormal_immune_serum2.44498742
38MP0008260_abnormal_autophagy2.44395962
39MP0000685_abnormal_immune_system2.40381809
40MP0003172_abnormal_lysosome_physiology2.37265686
41MP0001533_abnormal_skeleton_physiology2.29021779
42MP0002420_abnormal_adaptive_immunity2.26872152
43MP0001819_abnormal_immune_cell2.25521128
44MP0003191_abnormal_cellular_cholesterol2.20169660
45MP0003283_abnormal_digestive_organ2.19645433
46MP0004510_myositis2.13851105
47MP0004885_abnormal_endolymph2.12822719
48MP0009278_abnormal_bone_marrow2.09357007
49MP0002272_abnormal_nervous_system2.05012786
50MP0001529_abnormal_vocalization2.02523112
51MP0006292_abnormal_olfactory_placode1.96289433
52MP0001501_abnormal_sleep_pattern1.93841291
53MP0003718_maternal_effect1.93600763
54MP0002734_abnormal_mechanical_nocicepti1.92506906
55MP0002405_respiratory_system_inflammati1.91861955
56MP0005464_abnormal_platelet_physiology1.88929766
57MP0009764_decreased_sensitivity_to1.88805162
58MP0003075_altered_response_to1.87548154
59MP0003136_yellow_coat_color1.87334711
60MP0001905_abnormal_dopamine_level1.86721573
61MP0001845_abnormal_inflammatory_respons1.84242382
62MP0010155_abnormal_intestine_physiology1.74677519
63MP0003787_abnormal_imprinting1.74103663
64MP0004947_skin_inflammation1.73153369
65MP0000569_abnormal_digit_pigmentation1.70420744
66MP0009840_abnormal_foam_cell1.68424407
67MP0000343_altered_response_to1.67514517
68MP0001970_abnormal_pain_threshold1.64716526
69MP0000015_abnormal_ear_pigmentation1.64571496
70MP0008469_abnormal_protein_level1.63373912
71MP0000716_abnormal_immune_system1.61869281
72MP0006276_abnormal_autonomic_nervous1.61672271
73MP0002067_abnormal_sensory_capabilities1.59422095
74MP0004142_abnormal_muscle_tone1.59124552
75MP0001545_abnormal_hematopoietic_system1.57368798
76MP0005397_hematopoietic_system_phenotyp1.57368798
77MP0005386_behavior/neurological_phenoty1.54892151
78MP0004924_abnormal_behavior1.54892151
79MP0002998_abnormal_bone_remodeling1.54491386
80MP0003806_abnormal_nucleotide_metabolis1.54098734
81MP0003828_pulmonary_edema1.53864917
82MP0002733_abnormal_thermal_nociception1.52977682
83MP0002398_abnormal_bone_marrow1.49651578
84MP0005310_abnormal_salivary_gland1.49306971
85MP0009333_abnormal_splenocyte_physiolog1.45421142
86MP0001853_heart_inflammation1.43712161
87MP0000858_altered_metastatic_potential1.41309933
88MP0008569_lethality_at_weaning1.40411937
89MP0003690_abnormal_glial_cell1.37834399
90MP0008877_abnormal_DNA_methylation1.37435484
91MP0000689_abnormal_spleen_morphology1.29884105
92MP0002638_abnormal_pupillary_reflex1.29715804
93MP0003183_abnormal_peptide_metabolism1.29195119
94MP0003763_abnormal_thymus_physiology1.26569557
95MP0003329_amyloid_beta_deposits1.26242036
96MP0002429_abnormal_blood_cell1.26169563
97MP0003693_abnormal_embryo_hatching1.24963933
98MP0005167_abnormal_blood-brain_barrier1.23558350
99MP0002722_abnormal_immune_system1.23323192
100MP0005166_decreased_susceptibility_to1.21997076
101MP0003448_altered_tumor_morphology1.21300180
102MP0002557_abnormal_social/conspecific_i1.20270643
103MP0000465_gastrointestinal_hemorrhage1.19061877
104MP0003123_paternal_imprinting1.18689135
105MP0001485_abnormal_pinna_reflex1.18242737
106MP0003879_abnormal_hair_cell1.16754611
107MP0004484_altered_response_of1.15230227
108MP0003633_abnormal_nervous_system1.11876333
109MP0000778_abnormal_nervous_system1.11564694
110MP0004742_abnormal_vestibular_system1.11410648
111MP0005451_abnormal_body_composition1.08466968
112MP0002132_abnormal_respiratory_system1.08024772
113MP0002277_abnormal_respiratory_mucosa1.07225191
114MP0005164_abnormal_response_to1.06739320
115MP0001502_abnormal_circadian_rhythm1.06386094
116MP0001851_eye_inflammation1.05855513
117MP0008004_abnormal_stomach_pH1.05298644
118MP0002066_abnormal_motor_capabilities/c1.04744144
119MP0005423_abnormal_somatic_nervous1.04229205
120MP0001542_abnormal_bone_strength1.02850698
121MP0001963_abnormal_hearing_physiology1.02559003
122MP0004858_abnormal_nervous_system1.02290082
123MP0000462_abnormal_digestive_system1.00319191
124MP0003656_abnormal_erythrocyte_physiolo0.99470298
125MP0002163_abnormal_gland_morphology0.99249605
126MP0003111_abnormal_nucleus_morphology0.98641166
127MP0003631_nervous_system_phenotype0.98481323
128MP0004811_abnormal_neuron_physiology0.98006636
129MP0008961_abnormal_basal_metabolism0.97930407
130MP0005390_skeleton_phenotype0.96010605
131MP0002882_abnormal_neuron_morphology0.95732046
132MP0002069_abnormal_eating/drinking_beha0.95572488
133MP0003866_abnormal_defecation0.94907105
134MP0009763_increased_sensitivity_to0.94056512
135MP0003941_abnormal_skin_development0.93643748
136MP0003453_abnormal_keratinocyte_physiol0.91636642
137MP0001177_atelectasis0.86498726
138MP0000750_abnormal_muscle_regeneration0.86479244
139MP0001663_abnormal_digestive_system0.85314606
140MP0002254_reproductive_system_inflammat0.85079190
141MP0000703_abnormal_thymus_morphology0.84975850
142MP0006054_spinal_hemorrhage0.84200402
143MP0002876_abnormal_thyroid_physiology0.83774296
144MP0005448_abnormal_energy_balance0.81952070
145MP0009697_abnormal_copulation0.81756081
146MP0002184_abnormal_innervation0.81585787
147MP0004145_abnormal_muscle_electrophysio0.80487967
148MP0002332_abnormal_exercise_endurance0.79568425
149MP0002138_abnormal_hepatobiliary_system0.77259854
150MP0000920_abnormal_myelination0.75969374
151MP0003795_abnormal_bone_structure0.75614610
152MP0009765_abnormal_xenobiotic_induced0.73856710
153MP0000604_amyloidosis0.73142099
154MP0005646_abnormal_pituitary_gland0.71252633
155MP0002139_abnormal_hepatobiliary_system0.70678958
156MP0002933_joint_inflammation0.70471900
157MP0008874_decreased_physiological_sensi0.69784886
158MP0000490_abnormal_crypts_of0.68929751
159MP0003938_abnormal_ear_development0.67242010
160MP0004883_abnormal_blood_vessel0.66397828
161MP0001873_stomach_inflammation0.66178310
162MP0004808_abnormal_hematopoietic_stem0.65254079
163MP0000751_myopathy0.64478750
164MP0000249_abnormal_blood_vessel0.64410506
165MP0008875_abnormal_xenobiotic_pharmacok0.63157776
166MP0002152_abnormal_brain_morphology0.62898507
167MP0000026_abnormal_inner_ear0.62731137
168MP0005319_abnormal_enzyme/_coenzyme0.62720521
169MP0003698_abnormal_male_reproductive0.62242585
170MP0003091_abnormal_cell_migration0.60333359
171MP0002102_abnormal_ear_morphology0.59415375
172MP0003632_abnormal_nervous_system0.57827990
173MP0008872_abnormal_physiological_respon0.57447343
174MP0000013_abnormal_adipose_tissue0.57385390
175MP0003890_abnormal_embryonic-extraembry0.57363614
176MP0005410_abnormal_fertilization0.57042760
177MP0002396_abnormal_hematopoietic_system0.56723396
178MP0008995_early_reproductive_senescence0.56430322
179MP0005595_abnormal_vascular_smooth0.54254714
180MP0003121_genomic_imprinting0.54128047
181MP0005174_abnormal_tail_pigmentation0.53923187
182MP0004381_abnormal_hair_follicle0.52669311
183MP0005379_endocrine/exocrine_gland_phen0.52642977
184MP0005084_abnormal_gallbladder_morpholo0.52559483
185MP0005076_abnormal_cell_differentiation0.51621259
186MP0000747_muscle_weakness0.51364958
187MP0003045_fibrosis0.49206714
188MP0005165_increased_susceptibility_to0.48306202
189MP0000609_abnormal_liver_physiology0.47214784
190MP0005381_digestive/alimentary_phenotyp0.46690424
191MP0005365_abnormal_bile_salt0.46067850
192MP0005535_abnormal_body_temperature0.44686413

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.84657937
2Eczematoid dermatitis (HP:0000976)6.18025450
3Abnormality of macrophages (HP:0004311)5.99544562
4Recurrent abscess formation (HP:0002722)5.91121960
5Recurrent bacterial skin infections (HP:0005406)5.88053903
6Myositis (HP:0100614)5.29144550
7Orchitis (HP:0100796)5.08747844
8Abnormality of glycosphingolipid metabolism (HP:0004343)5.07410993
9Abnormality of glycolipid metabolism (HP:0010969)5.07410993
10Abnormality of liposaccharide metabolism (HP:0010968)5.07410993
11Recurrent gram-negative bacterial infections (HP:0005420)4.91959023
12Optic neuritis (HP:0100653)4.83634330
13Retrobulbar optic neuritis (HP:0100654)4.83634330
14Stomatitis (HP:0010280)4.80118566
15Epileptic encephalopathy (HP:0200134)4.58279189
16Mutism (HP:0002300)4.46562703
17Focal seizures (HP:0007359)4.39288127
18Mediastinal lymphadenopathy (HP:0100721)4.19744958
19Increased cerebral lipofuscin (HP:0011813)3.99054930
20Obstructive lung disease (HP:0006536)3.90939210
21Chronic obstructive pulmonary disease (HP:0006510)3.90939210
22Febrile seizures (HP:0002373)3.86472705
23Elevated erythrocyte sedimentation rate (HP:0003565)3.82523695
24Myokymia (HP:0002411)3.70486396
25Recurrent skin infections (HP:0001581)3.61704406
26Short tibia (HP:0005736)3.59459627
27Recurrent fungal infections (HP:0002841)3.55141489
28Loss of speech (HP:0002371)3.47380673
29Vacuolated lymphocytes (HP:0001922)3.44079226
30Hyperglycinemia (HP:0002154)3.41238745
31Systemic lupus erythematosus (HP:0002725)3.40589049
32Keratoconjunctivitis sicca (HP:0001097)3.39362837
33Meningitis (HP:0001287)3.38011015
34Broad-based gait (HP:0002136)3.36252363
35Disinhibition (HP:0000734)3.33904291
36Dysostosis multiplex (HP:0000943)3.31004340
37Increased neuronal autofluorescent lipopigment (HP:0002074)3.29873553
38Gastrointestinal infarctions (HP:0005244)3.25283721
39Spontaneous hematomas (HP:0007420)3.21163280
40Gingivitis (HP:0000230)3.20053148
41Submucous cleft hard palate (HP:0000176)3.14098052
42Urticaria (HP:0001025)3.13053889
43Keratoconjunctivitis (HP:0001096)3.12656509
44Amyloidosis (HP:0011034)3.11114249
45Vasculitis (HP:0002633)3.10439876
46Abnormality of the labia minora (HP:0012880)3.09467347
47Encephalitis (HP:0002383)3.06778201
48Hyperventilation (HP:0002883)3.01764436
49Aplasia/Hypoplasia of the tibia (HP:0005772)3.01155885
50Increased IgE level (HP:0003212)2.98281454
51Dialeptic seizures (HP:0011146)2.96064145
52Pulmonary infiltrates (HP:0002113)2.94051664
53Ventricular fibrillation (HP:0001663)2.90267424
54Petechiae (HP:0000967)2.90081061
55Hemoptysis (HP:0002105)2.89842172
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.89656885
57Recurrent cutaneous fungal infections (HP:0011370)2.88315702
58Chronic mucocutaneous candidiasis (HP:0002728)2.88315702
59Inability to walk (HP:0002540)2.84157952
60Generalized tonic-clonic seizures (HP:0002069)2.81776909
61Confusion (HP:0001289)2.81033799
62Purpura (HP:0000979)2.80496490
63Hyperglycinuria (HP:0003108)2.78183467
64Gait imbalance (HP:0002141)2.76866952
65Episodic fever (HP:0001954)2.75780660
66Atonic seizures (HP:0010819)2.75650909
67Increased serum ferritin (HP:0003281)2.75005683
68Autoimmune thrombocytopenia (HP:0001973)2.63732310
69Congenital primary aphakia (HP:0007707)2.62765265
70Bundle branch block (HP:0011710)2.62396408
71Cellulitis (HP:0100658)2.61625731
72Small epiphyses (HP:0010585)2.61143051
73Prolonged bleeding time (HP:0003010)2.60310309
74Nephrogenic diabetes insipidus (HP:0009806)2.58728257
75Abnormality of polysaccharide metabolism (HP:0011012)2.58462084
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.58462084
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.58462084
78Fetal akinesia sequence (HP:0001989)2.57946441
79Hepatosplenomegaly (HP:0001433)2.53307818
80Anorexia (HP:0002039)2.52555949
81Increased IgM level (HP:0003496)2.52030256
82Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.49086062
83Recurrent viral infections (HP:0004429)2.48518422
84J-shaped sella turcica (HP:0002680)2.48125221
85Abnormal eating behavior (HP:0100738)2.47824959
86Chest pain (HP:0100749)2.46442070
87Epileptiform EEG discharges (HP:0011182)2.43507119
88Medial flaring of the eyebrow (HP:0010747)2.42689599
89Arterial thrombosis (HP:0004420)2.42482625
90Visual hallucinations (HP:0002367)2.41175700
91Absence seizures (HP:0002121)2.41027565
92Progressive cerebellar ataxia (HP:0002073)2.40521837
93Pulmonary embolism (HP:0002204)2.40341406
94Gout (HP:0001997)2.38824280
95Mucopolysacchariduria (HP:0008155)2.37937446
96Urinary glycosaminoglycan excretion (HP:0003541)2.37937446
97Abnormality of iron homeostasis (HP:0011031)2.37634967
98Cerebral hypomyelination (HP:0006808)2.37273439
99Gaze-evoked nystagmus (HP:0000640)2.37065376
100Poor coordination (HP:0002370)2.36945587
101Leukocytosis (HP:0001974)2.36377396
102External ophthalmoplegia (HP:0000544)2.34370555
103Gangrene (HP:0100758)2.34241388
104Epistaxis (HP:0000421)2.33381269
105Fair hair (HP:0002286)2.32813627
106Hypochromic microcytic anemia (HP:0004840)2.30772328
107Polyphagia (HP:0002591)2.30486352
108Gingival bleeding (HP:0000225)2.30248073
109T lymphocytopenia (HP:0005403)2.29510402
110Abnormality of the lower motor neuron (HP:0002366)2.29052253
111Pustule (HP:0200039)2.26994373
112Inflammation of the large intestine (HP:0002037)2.25289242
113Relative macrocephaly (HP:0004482)2.25223828
114Hypochromic anemia (HP:0001931)2.24417604
115Abnormality of glycine metabolism (HP:0010895)2.24101817
116Abnormality of serine family amino acid metabolism (HP:0010894)2.24101817
117Hematochezia (HP:0002573)2.22001499
118Osteomyelitis (HP:0002754)2.19384858
119Hypergammaglobulinemia (HP:0010702)2.17880319
120Abnormality of T cell number (HP:0011839)2.17459249
121Atrioventricular block (HP:0001678)2.16373505
122Gastrointestinal inflammation (HP:0004386)2.16000369
123Irregular epiphyses (HP:0010582)2.15422909
124Polyneuropathy (HP:0001271)2.15355981
125Popliteal pterygium (HP:0009756)2.14067875
126Abnormality of the pleura (HP:0002103)2.14017514
127Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.13251367
128Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.12579101
129Axonal loss (HP:0003447)2.12336969
130Premature loss of primary teeth (HP:0006323)2.12316872
131Interstitial pulmonary disease (HP:0006530)2.11403681
132Oligomenorrhea (HP:0000876)2.11028129
133Progressive neurologic deterioration (HP:0002344)2.10823069
134Upper motor neuron abnormality (HP:0002127)2.10580219
135Patent foramen ovale (HP:0001655)2.09740420
136Diplopia (HP:0000651)2.09441569
137Abnormality of binocular vision (HP:0011514)2.09441569
138Spinal cord compression (HP:0002176)2.08954960
139Bradycardia (HP:0001662)2.08008057
140Carpal bone hypoplasia (HP:0001498)2.06303930
141Neuronal loss in central nervous system (HP:0002529)2.06297126
142Glomerulonephritis (HP:0000099)2.04518221
143Peritonitis (HP:0002586)2.04178094
144Hypoplasia of the capital femoral epiphysis (HP:0003090)2.04151146
145Symphalangism affecting the phalanges of the hand (HP:0009773)2.03756718
146Malnutrition (HP:0004395)2.01185243
147Vertigo (HP:0002321)2.00246240
148Curly hair (HP:0002212)1.99978049
149Breast hypoplasia (HP:0003187)1.99483915
150Abnormal spermatogenesis (HP:0008669)1.99217240
151Acne (HP:0001061)1.98459382
152Colitis (HP:0002583)1.97514070
153Glomerulopathy (HP:0100820)1.96766584
154Agnosia (HP:0010524)1.95851909
155Sepsis (HP:0100806)1.94394506
156Aplasia/hypoplasia of the humerus (HP:0006507)1.93978513
157Abnormality of the pericardium (HP:0001697)1.91912436
158EEG with generalized epileptiform discharges (HP:0011198)1.91634638
159Abnormality of the endocardium (HP:0004306)1.91098915
160Abnormality of transition element cation homeostasis (HP:0011030)1.90988251
161Hypsarrhythmia (HP:0002521)1.90923340
162Pathologic fracture (HP:0002756)1.90343233
163Alveolar cell carcinoma (HP:0006519)1.89748299
164Patellar aplasia (HP:0006443)1.89143506
165Premature rupture of membranes (HP:0001788)1.88192302
166Heart block (HP:0012722)1.85661425
167Excessive salivation (HP:0003781)1.85047145
168Drooling (HP:0002307)1.85047145
169Multiple enchondromatosis (HP:0005701)1.83523300
170Flat capital femoral epiphysis (HP:0003370)1.82211733
171Shawl scrotum (HP:0000049)1.81499563
172Aplasia/Hypoplasia of the patella (HP:0006498)1.81249776
173Incomplete penetrance (HP:0003829)1.80325755
174Abnormal respiratory epithelium morphology (HP:0012253)1.78123317
175Abnormal respiratory motile cilium morphology (HP:0005938)1.78123317
176Neonatal short-limb short stature (HP:0008921)1.77096795
177Ileus (HP:0002595)1.76479992
178Short humerus (HP:0005792)1.76364632
179Abnormality of the epiphysis of the femoral head (HP:0010574)1.75068234
180Iris hypopigmentation (HP:0007730)1.74725686
181Shoulder girdle muscle weakness (HP:0003547)1.74476078
182Syncope (HP:0001279)1.73651630
183Rectal fistula (HP:0100590)1.73312722
184Rectovaginal fistula (HP:0000143)1.73312722
185Stereotypic behavior (HP:0000733)1.73310639
186Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.71597384
187Blue irides (HP:0000635)1.71034108
188Stomach cancer (HP:0012126)1.70090155
189Generalized hypopigmentation of hair (HP:0011358)1.68266091
190Abnormal delivery (HP:0001787)1.68252894
191Abnormal atrioventricular conduction (HP:0005150)1.67859109
192Vaginal atresia (HP:0000148)1.67432591
193Muscle fiber splitting (HP:0003555)1.67293096
194Fibular hypoplasia (HP:0003038)1.66746798
195Abnormality of the corticospinal tract (HP:0002492)1.65236212
196Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.65161773
197Protruding tongue (HP:0010808)1.65043318
198Infertility (HP:0000789)1.64863660
199Abnormality of serum amino acid levels (HP:0003112)1.64511839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.65708636
2CASK4.28303304
3AKT33.71228785
4BLK3.49958100
5NTRK33.41576371
6MAP4K13.13057249
7IRAK43.11899755
8DAPK23.01971501
9MAP2K32.94560023
10PNCK2.89832546
11TYK22.85198505
12ERN12.76130030
13CSK2.69418537
14MAP2K72.59436987
15MAP3K42.53430793
16MST1R2.45390527
17MAP3K142.22189807
18TAOK12.21557131
19MAP3K32.15673701
20FGR2.15393343
21MAP3K112.14286390
22PDK22.11990466
23TNK22.07358711
24MAP3K122.00973703
25TSSK61.98687877
26BUB11.97647241
27TBK11.96747047
28EPHA41.96522197
29ZAP701.94468439
30CCNB11.79272030
31TAOK21.78478378
32JAK31.73858424
33PLK21.71166977
34EIF2AK31.69370013
35IKBKE1.61194510
36MATK1.59441165
37TXK1.57911771
38DAPK11.57281630
39SYK1.56382554
40GRK61.55911758
41BTK1.54562307
42TGFBR21.54296488
43HCK1.52157432
44MARK11.48478920
45EPHB11.47248226
46MAP3K131.45272575
47LYN1.39869152
48CSF1R1.38727228
49IKBKB1.38710052
50MINK11.37225234
51NEK61.36380441
52SIK31.34174917
53LATS21.33778620
54MAP3K11.27078016
55CDK191.26806901
56JAK21.25414589
57MAP2K41.24745536
58OXSR11.19889867
59PRKCG1.18969049
60ZAK1.16096147
61JAK11.15660558
62BRAF1.15083907
63CAMKK21.12910013
64RIPK41.10614365
65KIT1.09629641
66CLK11.09454505
67LCK1.08643484
68SGK2231.06899850
69SGK4941.06899850
70NME21.05365259
71SGK21.03823319
72BMPR21.03191826
73MARK31.02428259
74TESK21.00261415
75IRAK20.98022181
76IRAK10.97111729
77ALK0.96468006
78NTRK20.96334586
79PAK60.96306588
80MKNK20.96073504
81CDC42BPA0.96062595
82MOS0.95900868
83CAMK2B0.95216909
84PIK3CA0.92896965
85PDK30.92737801
86PDK40.92737801
87KSR20.88450122
88CDK50.88238329
89MARK20.86985255
90LATS10.84995926
91STK100.82782350
92ADRBK20.81147358
93EPHA20.80222899
94PLK30.79875936
95CSNK1G20.79615224
96CAMK2A0.79288169
97UHMK10.79245953
98TTK0.78548588
99IRAK30.78536734
100PDPK10.78287477
101STK380.76887719
102PRPF4B0.76747833
103SIK20.76374075
104TAOK30.76191961
105MAP3K90.75511497
106MAPK130.75307211
107PRKD20.75193464
108ITK0.73881824
109MAP3K60.73403044
110CDK11A0.73112355
111MAP3K50.71489767
112TRIB30.70953802
113RIPK10.70837454
114WEE10.69433000
115TEC0.67499438
116MKNK10.66902381
117GRK10.65800638
118NUAK10.64937971
119CAMKK10.59022467
120PTK60.58754363
121PRKCE0.58408400
122NME10.57812748
123CDK180.57811435
124FYN0.57321475
125CDK150.57313980
126PLK40.56434086
127SGK30.55966378
128MAP2K60.55315879
129CAMK2G0.54590189
130PTK2B0.54228616
131FES0.53303373
132CAMK2D0.53148039
133MAPK70.52991574
134NEK10.52763979
135CSNK1E0.51619783
136RPS6KC10.50491118
137RPS6KL10.50491118
138SIK10.50055050
139MAPK120.49952385
140CSNK1A10.49809145
141DYRK30.48655097
142CDK140.47777442
143DAPK30.47751620
144SGK10.47734652
145PDK10.47549518
146GRK70.47243971
147CHUK0.46968814
148STK38L0.46533714
149WNK30.46327124
150GRK50.45581042
151PRKG10.45442582
152PRKCH0.44071734
153EPHA30.43596148
154DYRK1B0.41475024
155EIF2AK20.41269920
156RPS6KA60.40859865
157STK110.40192039
158HIPK20.39985593
159NEK20.39851324
160DDR20.39346836
161PIM10.39260601
162DYRK20.38666705
163ABL20.38034250
164PAK30.37603748
165CAMK1D0.37161643
166STK30.37030184
167SMG10.36537791
168DYRK1A0.35908961
169BMX0.35362469
170YES10.35258545
171PRKCQ0.35177618
172NLK0.34345398
173ABL10.33859803
174AURKA0.33481587
175PRKG20.33410465
176MAPKAPK20.32845501
177STK390.32376728
178MAPK40.31787129
179LRRK20.31738321
180WNK10.31467758
181PRKCD0.30036883
182ACVR1B0.29897220
183RPS6KA20.28742481
184MAP3K70.28500992

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007507.58308786
2Nicotine addiction_Homo sapiens_hsa050334.39582920
3Staphylococcus aureus infection_Homo sapiens_hsa051503.12440503
4* Osteoclast differentiation_Homo sapiens_hsa043803.08335871
5Leishmaniasis_Homo sapiens_hsa051403.02595839
6Synaptic vesicle cycle_Homo sapiens_hsa047212.97348904
7Allograft rejection_Homo sapiens_hsa053302.52523138
8Other glycan degradation_Homo sapiens_hsa005112.51857631
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.50890910
10Graft-versus-host disease_Homo sapiens_hsa053322.41331832
11GABAergic synapse_Homo sapiens_hsa047272.39339053
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.38384483
13Collecting duct acid secretion_Homo sapiens_hsa049662.37052664
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.36048105
15Tuberculosis_Homo sapiens_hsa051522.34806518
16Morphine addiction_Homo sapiens_hsa050322.32976250
17Autoimmune thyroid disease_Homo sapiens_hsa053202.18992075
18Amphetamine addiction_Homo sapiens_hsa050312.18947243
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.17519848
20Malaria_Homo sapiens_hsa051442.14494993
21Sulfur metabolism_Homo sapiens_hsa009202.11442654
22NOD-like receptor signaling pathway_Homo sapiens_hsa046212.05747451
23Glutamatergic synapse_Homo sapiens_hsa047242.01707969
24Circadian entrainment_Homo sapiens_hsa047132.00991789
25Lysosome_Homo sapiens_hsa041421.99612040
26Asthma_Homo sapiens_hsa053101.99147391
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97315797
28Vitamin digestion and absorption_Homo sapiens_hsa049771.93882195
29Regulation of autophagy_Homo sapiens_hsa041401.93574539
30Long-term potentiation_Homo sapiens_hsa047201.86993232
31Legionellosis_Homo sapiens_hsa051341.85937396
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.83896715
33B cell receptor signaling pathway_Homo sapiens_hsa046621.82183887
34Serotonergic synapse_Homo sapiens_hsa047261.80504120
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74147647
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.72474128
37Olfactory transduction_Homo sapiens_hsa047401.71724702
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.70171955
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70024892
40Hematopoietic cell lineage_Homo sapiens_hsa046401.68923120
41Pertussis_Homo sapiens_hsa051331.67965543
42Antigen processing and presentation_Homo sapiens_hsa046121.67351459
43TNF signaling pathway_Homo sapiens_hsa046681.61550737
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.59660179
45Toxoplasmosis_Homo sapiens_hsa051451.58489414
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56312074
47Influenza A_Homo sapiens_hsa051641.52274914
48Chemokine signaling pathway_Homo sapiens_hsa040621.48956201
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.48543773
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47520374
51Viral myocarditis_Homo sapiens_hsa054161.47237778
52African trypanosomiasis_Homo sapiens_hsa051431.46375773
53Salmonella infection_Homo sapiens_hsa051321.44775576
54Measles_Homo sapiens_hsa051621.44223857
55RNA polymerase_Homo sapiens_hsa030201.41625546
56Sulfur relay system_Homo sapiens_hsa041221.40770216
57Primary immunodeficiency_Homo sapiens_hsa053401.40095035
58Dopaminergic synapse_Homo sapiens_hsa047281.38267511
59Taste transduction_Homo sapiens_hsa047421.38213343
60Circadian rhythm_Homo sapiens_hsa047101.36460366
61Acute myeloid leukemia_Homo sapiens_hsa052211.35808271
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31796291
63Herpes simplex infection_Homo sapiens_hsa051681.27989519
64Long-term depression_Homo sapiens_hsa047301.23568428
65Glycerophospholipid metabolism_Homo sapiens_hsa005641.23203866
66Cocaine addiction_Homo sapiens_hsa050301.19722837
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19109588
68Jak-STAT signaling pathway_Homo sapiens_hsa046301.15911097
69Calcium signaling pathway_Homo sapiens_hsa040201.15425180
70T cell receptor signaling pathway_Homo sapiens_hsa046601.14853098
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12552088
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11367869
73Cholinergic synapse_Homo sapiens_hsa047251.10943998
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10576286
75Rheumatoid arthritis_Homo sapiens_hsa053231.09986183
76Shigellosis_Homo sapiens_hsa051311.06998384
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06623386
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03644753
79Oxidative phosphorylation_Homo sapiens_hsa001901.03201314
80Hepatitis C_Homo sapiens_hsa051601.02313470
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01994169
82Ether lipid metabolism_Homo sapiens_hsa005651.01854806
83Proteasome_Homo sapiens_hsa030501.01067173
84Insulin secretion_Homo sapiens_hsa049111.00420414
85Oxytocin signaling pathway_Homo sapiens_hsa049210.99970494
86Salivary secretion_Homo sapiens_hsa049700.99109301
87Hepatitis B_Homo sapiens_hsa051610.98850945
88Butanoate metabolism_Homo sapiens_hsa006500.96617566
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93666775
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.92866212
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92525242
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88348116
93Axon guidance_Homo sapiens_hsa043600.85933941
94Phototransduction_Homo sapiens_hsa047440.85869433
95Apoptosis_Homo sapiens_hsa042100.85498149
96Vibrio cholerae infection_Homo sapiens_hsa051100.84690901
97Oocyte meiosis_Homo sapiens_hsa041140.81807504
98ErbB signaling pathway_Homo sapiens_hsa040120.80944114
99Amoebiasis_Homo sapiens_hsa051460.80561050
100Platelet activation_Homo sapiens_hsa046110.79722381
101VEGF signaling pathway_Homo sapiens_hsa043700.75662097
102Renin secretion_Homo sapiens_hsa049240.71736493
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69697451
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.68677134
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.67525055
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67243187
107Epstein-Barr virus infection_Homo sapiens_hsa051690.66338254
108Huntingtons disease_Homo sapiens_hsa050160.65412468
109cAMP signaling pathway_Homo sapiens_hsa040240.64085322
110Prolactin signaling pathway_Homo sapiens_hsa049170.63824190
111Endocytosis_Homo sapiens_hsa041440.62589269
112Pancreatic secretion_Homo sapiens_hsa049720.61000586
113Pancreatic cancer_Homo sapiens_hsa052120.60982614
114Folate biosynthesis_Homo sapiens_hsa007900.60168124
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.59789681
116Arginine and proline metabolism_Homo sapiens_hsa003300.59604034
117Linoleic acid metabolism_Homo sapiens_hsa005910.59492596
118Phagosome_Homo sapiens_hsa041450.59076835
119Chronic myeloid leukemia_Homo sapiens_hsa052200.58887636
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57868378
121Non-small cell lung cancer_Homo sapiens_hsa052230.57803983
122Prion diseases_Homo sapiens_hsa050200.57686548
123Estrogen signaling pathway_Homo sapiens_hsa049150.56135292
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56093588
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55041133
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53552299
127GnRH signaling pathway_Homo sapiens_hsa049120.52568760
128Alzheimers disease_Homo sapiens_hsa050100.52277150
129Complement and coagulation cascades_Homo sapiens_hsa046100.49655121
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49513802
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.48382472
132Cardiac muscle contraction_Homo sapiens_hsa042600.48365138
133Renal cell carcinoma_Homo sapiens_hsa052110.48315354
134Fatty acid elongation_Homo sapiens_hsa000620.48221027
135Notch signaling pathway_Homo sapiens_hsa043300.47690763
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46768739
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.46731967
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46633723
139Type II diabetes mellitus_Homo sapiens_hsa049300.46232128
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43734560
141HTLV-I infection_Homo sapiens_hsa051660.42827288
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.42492375
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42424145
144HIF-1 signaling pathway_Homo sapiens_hsa040660.42249263
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41180997
146Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40722443
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40712342
148Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39555168
149Viral carcinogenesis_Homo sapiens_hsa052030.39136531
150Gastric acid secretion_Homo sapiens_hsa049710.36215456
151FoxO signaling pathway_Homo sapiens_hsa040680.36129542
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35204523
153Fructose and mannose metabolism_Homo sapiens_hsa000510.35160765
154Galactose metabolism_Homo sapiens_hsa000520.35052919
155Arginine biosynthesis_Homo sapiens_hsa002200.34030859
156RNA transport_Homo sapiens_hsa030130.33832532
157Insulin resistance_Homo sapiens_hsa049310.32232337
158Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31619204
159Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31397834
160Choline metabolism in cancer_Homo sapiens_hsa052310.30968420
161Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30701262
162Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30099318
163Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28907574
164Steroid biosynthesis_Homo sapiens_hsa001000.28824276
165Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28767531
166Bladder cancer_Homo sapiens_hsa052190.28703152
167Ras signaling pathway_Homo sapiens_hsa040140.28483742
168Basal transcription factors_Homo sapiens_hsa030220.28475642
169Sphingolipid metabolism_Homo sapiens_hsa006000.28187948
170Parkinsons disease_Homo sapiens_hsa050120.28084094
171Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27553357
172Gap junction_Homo sapiens_hsa045400.27310201
173Dorso-ventral axis formation_Homo sapiens_hsa043200.26807049
174Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26405110
175Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26239061
176Mineral absorption_Homo sapiens_hsa049780.24743367
177Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24573776
178Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24111880
179Metabolic pathways_Homo sapiens_hsa011000.23863104
180MAPK signaling pathway_Homo sapiens_hsa040100.23851512
181mTOR signaling pathway_Homo sapiens_hsa041500.23502525
182Type I diabetes mellitus_Homo sapiens_hsa049400.21273286
183Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20856264
184beta-Alanine metabolism_Homo sapiens_hsa004100.20516214

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