OSER1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.36585450
2mitotic metaphase plate congression (GO:0007080)4.91249155
3DNA replication checkpoint (GO:0000076)4.26722093
4attachment of spindle microtubules to kinetochore (GO:0008608)4.26369865
5metaphase plate congression (GO:0051310)4.20754558
6CENP-A containing nucleosome assembly (GO:0034080)4.20474768
7meiotic chromosome segregation (GO:0045132)4.08460859
8chromatin remodeling at centromere (GO:0031055)4.05288942
9DNA methylation involved in gamete generation (GO:0043046)3.97480903
10signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.89666465
11intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.89666465
12signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.89120514
13signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.89120514
14signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.89120514
15establishment of chromosome localization (GO:0051303)3.83143100
16proteasome assembly (GO:0043248)3.81998927
17signal transduction involved in DNA integrity checkpoint (GO:0072401)3.72169792
18signal transduction involved in DNA damage checkpoint (GO:0072422)3.72169792
19signal transduction involved in cell cycle checkpoint (GO:0072395)3.70428445
20neutrophil activation involved in immune response (GO:0002283)3.70083058
21DNA replication-independent nucleosome organization (GO:0034724)3.67966721
22DNA replication-independent nucleosome assembly (GO:0006336)3.67966721
23histone exchange (GO:0043486)3.64548107
24positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.64259528
25regulation of cellular amino acid metabolic process (GO:0006521)3.64210531
26regulation of female gonad development (GO:2000194)3.59761658
27maturation of 5.8S rRNA (GO:0000460)3.58323896
28regulation of double-strand break repair via homologous recombination (GO:0010569)3.56286083
29microtubule depolymerization (GO:0007019)3.55879573
30protein localization to kinetochore (GO:0034501)3.55001985
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.54045685
32DNA strand elongation involved in DNA replication (GO:0006271)3.53611563
33positive regulation of ligase activity (GO:0051351)3.52658610
34telomere maintenance via recombination (GO:0000722)3.51472744
35cullin deneddylation (GO:0010388)3.48059069
36telomere maintenance via semi-conservative replication (GO:0032201)3.46504999
37antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.46095123
38protein K6-linked ubiquitination (GO:0085020)3.41055675
39DNA strand elongation (GO:0022616)3.40582675
40regulation of meiosis I (GO:0060631)3.37082701
41DNA replication initiation (GO:0006270)3.34983734
42DNA deamination (GO:0045006)3.34633861
43protein deneddylation (GO:0000338)3.30290225
44male meiosis (GO:0007140)3.29177138
45negative regulation of protein ubiquitination (GO:0031397)3.28930072
46RNA capping (GO:0036260)3.27707262
477-methylguanosine RNA capping (GO:0009452)3.27707262
487-methylguanosine mRNA capping (GO:0006370)3.27632456
49ribosome assembly (GO:0042255)3.24595671
50regulation of ubiquitin-protein transferase activity (GO:0051438)3.21985440
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.21508839
52negative regulation of meiosis (GO:0045835)3.21039609
53regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.20196952
54regulation of mitotic spindle checkpoint (GO:1903504)3.20196952
55protein localization to chromosome, centromeric region (GO:0071459)3.18126476
56regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.17639762
57purine nucleobase biosynthetic process (GO:0009113)3.16640556
58mitotic recombination (GO:0006312)3.16454624
59mitotic chromosome condensation (GO:0007076)3.14362509
60regulation of ligase activity (GO:0051340)3.14094663
61mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.13178714
62regulation of RIG-I signaling pathway (GO:0039535)3.11735268
63female gamete generation (GO:0007292)3.11688600
64spindle checkpoint (GO:0031577)3.10363013
65regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09406969
66DNA synthesis involved in DNA repair (GO:0000731)3.07479827
67maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.07202140
68positive regulation of protein homooligomerization (GO:0032464)3.06958599
69DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.05477345
70negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.05114563
71meiotic nuclear division (GO:0007126)3.04887349
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04571125
73negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02960746
74immunoglobulin mediated immune response (GO:0016064)3.01291558
75multicellular organism reproduction (GO:0032504)2.99983370
76regulation of spindle organization (GO:0090224)2.99008247
77oocyte maturation (GO:0001556)2.98799632
78kinetochore organization (GO:0051383)2.97373757
79synaptonemal complex assembly (GO:0007130)2.97323996
80transcription elongation from RNA polymerase III promoter (GO:0006385)2.97168181
81termination of RNA polymerase III transcription (GO:0006386)2.97168181
82chromosome segregation (GO:0007059)2.96889155
83regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.95289391
84transcription-coupled nucleotide-excision repair (GO:0006283)2.95012561
85mismatch repair (GO:0006298)2.94683617
86positive regulation of cell cycle arrest (GO:0071158)2.92704420
87kinetochore assembly (GO:0051382)2.92549228
88male meiosis I (GO:0007141)2.91784107
89protein neddylation (GO:0045116)2.91716102
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91319603
91replication fork processing (GO:0031297)2.91164630
92negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.90469205
93transcription elongation from RNA polymerase II promoter (GO:0006368)2.90266955
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90197300
95rRNA modification (GO:0000154)2.89944320
96regulation of chromosome segregation (GO:0051983)2.89099460
97regulation of retinoic acid receptor signaling pathway (GO:0048385)2.88982625
98negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87736507
99negative regulation of sister chromatid segregation (GO:0033046)2.87736507
100negative regulation of mitotic sister chromatid separation (GO:2000816)2.87736507
101negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87736507
102nucleotide-excision repair, DNA gap filling (GO:0006297)2.87314982
103regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.87038242
104termination of RNA polymerase I transcription (GO:0006363)2.85545343
105meiosis I (GO:0007127)2.85322533
106activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.85000997
107monoubiquitinated protein deubiquitination (GO:0035520)2.84436444
108positive regulation of chromosome segregation (GO:0051984)2.84265520
109regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84188857
110meiotic cell cycle (GO:0051321)2.83831572
111cellular response to zinc ion (GO:0071294)2.83428413
112antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.83138418
113negative regulation of chromosome segregation (GO:0051985)2.82811617
114mitotic sister chromatid segregation (GO:0000070)2.82506117
115L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82233206
116mitotic nuclear envelope disassembly (GO:0007077)2.81332019
117regulation of exit from mitosis (GO:0007096)2.81194511
118granulocyte activation (GO:0036230)2.80754913
119neutrophil activation (GO:0042119)2.79186467
120negative regulation of DNA-templated transcription, elongation (GO:0032785)2.78811237
121negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.78811237
122mitotic spindle checkpoint (GO:0071174)2.78397477
123regulation of spindle checkpoint (GO:0090231)2.76120648
124negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75975467
125negative regulation of ligase activity (GO:0051352)2.75975467
126exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75908061
127nucleobase biosynthetic process (GO:0046112)2.75560183
128protein K11-linked ubiquitination (GO:0070979)2.74973434
129transcription from RNA polymerase I promoter (GO:0006360)2.74847685
130transcription elongation from RNA polymerase I promoter (GO:0006362)2.73921452
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73512327
132mitotic spindle assembly checkpoint (GO:0007094)2.73320988
133meiotic cell cycle process (GO:1903046)2.72640773
134regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.66025416
135signal transduction in response to DNA damage (GO:0042770)2.64461679
136response to peptidoglycan (GO:0032494)2.63403345
137rRNA methylation (GO:0031167)2.62645517
138regulation of cellular amine metabolic process (GO:0033238)2.60150862
139nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.59770406
140B cell mediated immunity (GO:0019724)2.59134886
141positive regulation of protein ubiquitination (GO:0031398)2.55281746
142mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.51647358
143RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.47668403
144tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.47668403
145energy coupled proton transport, down electrochemical gradient (GO:0015985)2.42327451
146ATP synthesis coupled proton transport (GO:0015986)2.42327451
147DNA catabolic process, exonucleolytic (GO:0000738)2.38952201
148histone mRNA metabolic process (GO:0008334)2.38659247
149G1/S transition of mitotic cell cycle (GO:0000082)2.38446328
150cell cycle G1/S phase transition (GO:0044843)2.38446328
151negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.38125482
152respiratory electron transport chain (GO:0022904)2.38055482
153purine nucleotide salvage (GO:0032261)2.37918603
154establishment of protein localization to mitochondrial membrane (GO:0090151)2.37664318
155positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.37637379
156purine-containing compound salvage (GO:0043101)2.35522143
157negative regulation of cell cycle G1/S phase transition (GO:1902807)2.35164378
158negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.35164378
159single strand break repair (GO:0000012)2.35141136
160regulation of T-helper 1 cell differentiation (GO:0045625)2.33737645
161signal transduction by p53 class mediator (GO:0072331)2.33141207
162positive regulation of protein modification by small protein conjugation or removal (GO:1903322)2.32764040
163protein targeting to mitochondrion (GO:0006626)2.32597838
164electron transport chain (GO:0022900)2.31270390
165mitotic G2 DNA damage checkpoint (GO:0007095)2.30975705
166protein localization to mitochondrion (GO:0070585)2.30433697
167nucleoside salvage (GO:0043174)2.30288120
168natural killer cell mediated cytotoxicity (GO:0042267)2.28962768
169natural killer cell mediated immunity (GO:0002228)2.28962768
170chaperone-mediated protein transport (GO:0072321)2.28926384
171respiratory chain complex IV assembly (GO:0008535)2.28007952
172regulation of cytokine secretion involved in immune response (GO:0002739)2.27767815
173platelet dense granule organization (GO:0060155)2.25932586
174pyrimidine nucleoside salvage (GO:0043097)2.24686737
175pyrimidine-containing compound salvage (GO:0008655)2.24686737
176regulation of interferon-beta biosynthetic process (GO:0045357)2.24113449
177regulation of cell cycle arrest (GO:0071156)2.22302290
178negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.22271306
179regulation of protein ubiquitination (GO:0031396)2.21947295
180positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.19049744

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.49756909
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.90156008
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.43968336
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.39782128
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.22362380
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.12541971
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11883719
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.09346011
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91696530
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.82691844
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68233482
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57643280
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52555313
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44031427
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.38545614
16AR_21909140_ChIP-Seq_LNCAP_Human2.36289572
17VDR_23849224_ChIP-Seq_CD4+_Human2.34004187
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.32892181
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30319405
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.26065115
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.11789352
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07375680
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05083928
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04562104
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.00423808
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99439772
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98534952
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96278357
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.94208680
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.87399700
31FOXP3_21729870_ChIP-Seq_TREG_Human1.85554614
32DCP1A_22483619_ChIP-Seq_HELA_Human1.84445938
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83643495
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79395199
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78172570
36KAP1_22055183_ChIP-Seq_ESCs_Mouse1.77975257
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77815305
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.77093763
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.75979905
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75886828
41ELK1_19687146_ChIP-ChIP_HELA_Human1.75863265
42GABP_19822575_ChIP-Seq_HepG2_Human1.75811878
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74433736
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72015699
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.70143866
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63795839
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.62773000
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61279146
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57051099
50XRN2_22483619_ChIP-Seq_HELA_Human1.56631481
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56418615
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.56393644
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55493694
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54368593
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53183200
56TTF2_22483619_ChIP-Seq_HELA_Human1.43073734
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40659717
58ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.38494361
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37526816
60SPI1_23547873_ChIP-Seq_NB4_Human1.30671461
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30070586
62MYC_18940864_ChIP-ChIP_HL60_Human1.28079424
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27997651
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.27508974
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26807081
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25835940
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24982576
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22307814
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21963431
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20618052
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18772878
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16547594
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15220774
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14095643
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13875240
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12168448
77ELF5_23300383_ChIP-Seq_T47D_Human1.09440281
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09221769
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08485943
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08249369
81KDM5A_27292631_Chip-Seq_BREAST_Human1.07640968
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06484793
83IRF8_27001747_Chip-Seq_BMDM_Mouse1.05512358
84IRF1_19129219_ChIP-ChIP_H3396_Human1.04105034
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03888655
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.03517517
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03352614
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02394466
89GATA3_26560356_Chip-Seq_TH2_Human1.02171135
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01205411
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00955654
92SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00348426
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.98461921
94ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96859255
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96208322
96STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95051860
97CIITA_25753668_ChIP-Seq_RAJI_Human0.94758393
98MYB_26560356_Chip-Seq_TH1_Human0.94627701
99TFEB_21752829_ChIP-Seq_HELA_Human0.94111137
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92447183
101SALL4_22934838_ChIP-ChIP_CD34+_Human0.92021136
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91449828
103STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90179282
104EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88900884
105EGR1_19374776_ChIP-ChIP_THP-1_Human0.88799163
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87606497
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87109715
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86888574
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86212245
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85178472
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84403816
112RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84040687
113SALL1_21062744_ChIP-ChIP_HESCs_Human0.84002210
114FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83831226
115ZNF274_21170338_ChIP-Seq_K562_Hela0.81413254
116KLF4_18555785_ChIP-Seq_MESCs_Mouse0.80322986
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80008813
118MYB_26560356_Chip-Seq_TH2_Human0.79884688
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.79863873
120PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79377103
121CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.78108877
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.76723806
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75330514
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71233960
125PU.1_20513432_ChIP-Seq_Bcells_Mouse0.70116778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.60277883
2MP0010094_abnormal_chromosome_stability4.00682343
3MP0008877_abnormal_DNA_methylation3.89604868
4MP0003718_maternal_effect3.54636167
5MP0003077_abnormal_cell_cycle3.37252484
6MP0008058_abnormal_DNA_repair3.23371149
7MP0003111_abnormal_nucleus_morphology3.21192474
8MP0003806_abnormal_nucleotide_metabolis3.12674198
9MP0008007_abnormal_cellular_replicative3.04439719
10MP0008057_abnormal_DNA_replication2.94237888
11MP0004957_abnormal_blastocyst_morpholog2.93888950
12MP0006036_abnormal_mitochondrial_physio2.42552654
13MP0001835_abnormal_antigen_presentation2.15367477
14MP0001929_abnormal_gametogenesis2.08987046
15MP0005671_abnormal_response_to2.06105320
16MP0001119_abnormal_female_reproductive2.05955400
17MP0002277_abnormal_respiratory_mucosa2.01841639
18MP0002210_abnormal_sex_determination2.01516555
19MP0009764_decreased_sensitivity_to2.00961104
20MP0003191_abnormal_cellular_cholesterol1.96829928
21MP0008932_abnormal_embryonic_tissue1.96009549
22MP0006292_abnormal_olfactory_placode1.92241916
23MP0003786_premature_aging1.88235335
24MP0003646_muscle_fatigue1.84922653
25MP0003763_abnormal_thymus_physiology1.80015629
26MP0000653_abnormal_sex_gland1.76706218
27MP0005451_abnormal_body_composition1.74577340
28MP0009785_altered_susceptibility_to1.74340781
29MP0009333_abnormal_splenocyte_physiolog1.73484128
30MP0003221_abnormal_cardiomyocyte_apopto1.71733959
31MP0005408_hypopigmentation1.70947519
32MP0002332_abnormal_exercise_endurance1.70571956
33MP0002102_abnormal_ear_morphology1.61189951
34MP0002396_abnormal_hematopoietic_system1.60098465
35MP0001145_abnormal_male_reproductive1.52079907
36MP0003123_paternal_imprinting1.51277318
37MP0006035_abnormal_mitochondrial_morpho1.48663016
38MP0002148_abnormal_hypersensitivity_rea1.42481958
39MP0005000_abnormal_immune_tolerance1.40396690
40MP0000350_abnormal_cell_proliferation1.38716663
41MP0003699_abnormal_female_reproductive1.38130730
42MP0002419_abnormal_innate_immunity1.37501122
43MP0002019_abnormal_tumor_incidence1.36962312
44MP0002398_abnormal_bone_marrow1.35647104
45MP0002452_abnormal_antigen_presenting1.35544382
46MP0003303_peritoneal_inflammation1.33789246
47MP0008260_abnormal_autophagy1.33741845
48MP0003186_abnormal_redox_activity1.32503622
49MP0003943_abnormal_hepatobiliary_system1.31624815
50MP0003195_calcinosis1.31426848
51MP0005395_other_phenotype1.31397625
52MP0001800_abnormal_humoral_immune1.31284804
53MP0002420_abnormal_adaptive_immunity1.31116813
54MP0001819_abnormal_immune_cell1.30193816
55MP0001764_abnormal_homeostasis1.30019752
56MP0002723_abnormal_immune_serum1.28520709
57MP0002132_abnormal_respiratory_system1.27158623
58MP0005075_abnormal_melanosome_morpholog1.26158815
59MP0009840_abnormal_foam_cell1.23824401
60MP0009697_abnormal_copulation1.21846104
61MP0006082_CNS_inflammation1.21810304
62MP0008995_early_reproductive_senescence1.21491641
63MP0008004_abnormal_stomach_pH1.20326559
64MP0000689_abnormal_spleen_morphology1.19398667
65MP0009765_abnormal_xenobiotic_induced1.18853206
66MP0004808_abnormal_hematopoietic_stem1.18182657
67MP0002877_abnormal_melanocyte_morpholog1.18035172
68MP0005025_abnormal_response_to1.17009150
69MP0005389_reproductive_system_phenotype1.16966640
70MP0005377_hearing/vestibular/ear_phenot1.15811247
71MP0003878_abnormal_ear_physiology1.15811247
72MP0000716_abnormal_immune_system1.15458497
73MP0001730_embryonic_growth_arrest1.14332254
74MP0000313_abnormal_cell_death1.13086582
75MP0003724_increased_susceptibility_to1.12811291
76MP0003436_decreased_susceptibility_to1.12594772
77MP0005397_hematopoietic_system_phenotyp1.12316647
78MP0001545_abnormal_hematopoietic_system1.12316647
79MP0000490_abnormal_crypts_of1.10721437
80MP0005310_abnormal_salivary_gland1.09971518
81MP0002429_abnormal_blood_cell1.08528289
82MP0003828_pulmonary_edema1.08154286
83MP0008469_abnormal_protein_level1.07223137
84MP0002405_respiratory_system_inflammati1.07032384
85MP0010307_abnormal_tumor_latency1.06645397
86MP0004782_abnormal_surfactant_physiolog1.05449148
87MP0001919_abnormal_reproductive_system1.05257036
88MP0002722_abnormal_immune_system1.04880440
89MP0003698_abnormal_male_reproductive1.02272593
90MP0002161_abnormal_fertility/fecundity1.01993788
91MP0000465_gastrointestinal_hemorrhage1.01085448
92MP0002090_abnormal_vision1.00723034
93MP0003656_abnormal_erythrocyte_physiolo1.00031795
94MP0003315_abnormal_perineum_morphology0.99271882
95MP0005410_abnormal_fertilization0.98835584
96MP0000647_abnormal_sebaceous_gland0.97748691
97MP0004381_abnormal_hair_follicle0.97190615
98MP0005266_abnormal_metabolism0.94923244
99MP0000343_altered_response_to0.94229721
100MP0005464_abnormal_platelet_physiology0.93865099
101MP0000358_abnormal_cell_content/0.93830774
102MP0005387_immune_system_phenotype0.93401438
103MP0001790_abnormal_immune_system0.93401438
104MP0002006_tumorigenesis0.91465062
105MP0009763_increased_sensitivity_to0.90893984
106MP0001853_heart_inflammation0.90087950
107MP0002163_abnormal_gland_morphology0.89800506
108MP0008873_increased_physiological_sensi0.89251986
109MP0010155_abnormal_intestine_physiology0.87261335
110MP0001672_abnormal_embryogenesis/_devel0.84872980
111MP0005380_embryogenesis_phenotype0.84872980
112MP0001986_abnormal_taste_sensitivity0.84678938
113MP0000703_abnormal_thymus_morphology0.84549692
114MP0001845_abnormal_inflammatory_respons0.82022318
115MP0005376_homeostasis/metabolism_phenot0.81759007
116MP0001905_abnormal_dopamine_level0.81396435
117MP0000372_irregular_coat_pigmentation0.81108679
118MP0005367_renal/urinary_system_phenotyp0.79252632
119MP0000516_abnormal_urinary_system0.79252632
120MP0001697_abnormal_embryo_size0.78297659
121MP0001529_abnormal_vocalization0.77453989
122MP0008789_abnormal_olfactory_epithelium0.77224955
123MP0005164_abnormal_response_to0.77067176
124MP0001533_abnormal_skeleton_physiology0.75964638
125MP0000685_abnormal_immune_system0.75669119
126MP0002160_abnormal_reproductive_system0.75648174
127MP0001727_abnormal_embryo_implantation0.75491756
128MP0003448_altered_tumor_morphology0.75212053
129MP0003950_abnormal_plasma_membrane0.75064756
130MP0004510_myositis0.74898330
131MP0000858_altered_metastatic_potential0.72952202
132MP0004947_skin_inflammation0.72855857
133MP0002080_prenatal_lethality0.68859854
134MP0003121_genomic_imprinting0.68771746
135MP0005621_abnormal_cell_physiology0.66832662
136MP0002933_joint_inflammation0.64531500

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.23429236
2Chromsome breakage (HP:0040012)4.18710247
3Breast hypoplasia (HP:0003187)4.14703175
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.99926297
5Acute necrotizing encephalopathy (HP:0006965)3.64386693
63-Methylglutaconic aciduria (HP:0003535)3.46151949
7Acute encephalopathy (HP:0006846)3.41582324
8Carpal bone hypoplasia (HP:0001498)3.40388084
9Mitochondrial inheritance (HP:0001427)3.39994412
10Abnormal mitochondria in muscle tissue (HP:0008316)3.37399613
11Flat capital femoral epiphysis (HP:0003370)3.37116670
12Abnormal spermatogenesis (HP:0008669)3.29474031
13Patellar aplasia (HP:0006443)3.27366690
14Increased CSF lactate (HP:0002490)3.27010948
15Stomatitis (HP:0010280)3.26809402
16Progressive macrocephaly (HP:0004481)3.24975283
17Hepatocellular necrosis (HP:0001404)3.24454507
18Irregular epiphyses (HP:0010582)3.22186860
19Hepatic necrosis (HP:0002605)3.10384247
20Premature ovarian failure (HP:0008209)3.06387659
21Aplasia/Hypoplasia of the patella (HP:0006498)3.05861224
22Type 2 muscle fiber atrophy (HP:0003554)3.01677884
23Abnormality of chromosome stability (HP:0003220)2.91719439
24Abnormality of the preputium (HP:0100587)2.89659878
25Nausea (HP:0002018)2.89345467
26Dyschromatopsia (HP:0007641)2.86702869
27Azoospermia (HP:0000027)2.77923061
28Secondary amenorrhea (HP:0000869)2.77281452
29Aplastic anemia (HP:0001915)2.76827985
30Abnormality of lateral ventricle (HP:0030047)2.76707134
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.76578312
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.76578312
33Recurrent abscess formation (HP:0002722)2.75229550
34Meckel diverticulum (HP:0002245)2.69818858
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.67688769
36Cerebral hypomyelination (HP:0006808)2.66510510
37Impulsivity (HP:0100710)2.64388087
38Muscle fiber atrophy (HP:0100295)2.62616013
39Optic neuritis (HP:0100653)2.60119610
40Retrobulbar optic neuritis (HP:0100654)2.60119610
41Generalized aminoaciduria (HP:0002909)2.57587017
42Parakeratosis (HP:0001036)2.57437770
43Agnosia (HP:0010524)2.54316072
44Abnormality of the femoral head (HP:0003368)2.53950110
45Recurrent bacterial skin infections (HP:0005406)2.52999935
46Abnormal hemoglobin (HP:0011902)2.52542921
47Abnormality of the ileum (HP:0001549)2.51863754
48Severe visual impairment (HP:0001141)2.51136802
49Increased hepatocellular lipid droplets (HP:0006565)2.49973487
50Cerebral edema (HP:0002181)2.49731275
51Renal Fanconi syndrome (HP:0001994)2.47585895
52Hypoplasia of the capital femoral epiphysis (HP:0003090)2.46477297
53Abnormality of the epiphysis of the femoral head (HP:0010574)2.46210724
54Myositis (HP:0100614)2.45883239
55Abnormality of macrophages (HP:0004311)2.45677431
56Increased serum lactate (HP:0002151)2.45651184
57Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.44712865
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.44343349
59Bone marrow hypocellularity (HP:0005528)2.43265838
60Myelodysplasia (HP:0002863)2.40557194
61Lactic acidosis (HP:0003128)2.40489176
62Premature graying of hair (HP:0002216)2.39011757
63Respiratory difficulties (HP:0002880)2.36680287
64Capillary hemangiomas (HP:0005306)2.35156069
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34006003
66Duodenal stenosis (HP:0100867)2.30856816
67Small intestinal stenosis (HP:0012848)2.30856816
68Hypergonadotropic hypogonadism (HP:0000815)2.30776586
69Duplicated collecting system (HP:0000081)2.30485690
70Pancytopenia (HP:0001876)2.30049564
71Orchitis (HP:0100796)2.28182531
72Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.27732654
73Abnormality of femoral epiphyses (HP:0006499)2.27732654
74Male infertility (HP:0003251)2.27631062
75Absent epiphyses (HP:0010577)2.27374850
76Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.27374850
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.27206361
78Prostate neoplasm (HP:0100787)2.26123964
79Microvesicular hepatic steatosis (HP:0001414)2.26118668
80Clubbing of toes (HP:0100760)2.26051553
81Rough bone trabeculation (HP:0100670)2.25073784
82Lipid accumulation in hepatocytes (HP:0006561)2.24879570
83Combined immunodeficiency (HP:0005387)2.24822732
84Increased serum pyruvate (HP:0003542)2.24766274
85Adrenal hypoplasia (HP:0000835)2.24358118
86Abnormality of the renal collecting system (HP:0004742)2.21002508
87Metaphyseal dysplasia (HP:0100255)2.20041369
88Exercise intolerance (HP:0003546)2.19677565
89Median cleft lip (HP:0000161)2.19547561
90Increased intramyocellular lipid droplets (HP:0012240)2.16972176
91IgG deficiency (HP:0004315)2.16847384
92Posterior subcapsular cataract (HP:0007787)2.16441421
93Respiratory failure (HP:0002878)2.16251651
94Congenital ichthyosiform erythroderma (HP:0007431)2.15509120
95Abnormal lung lobation (HP:0002101)2.14769396
96Methylmalonic aciduria (HP:0012120)2.14589107
9711 pairs of ribs (HP:0000878)2.13534213
98Vacuolated lymphocytes (HP:0001922)2.11832085
99Abnormality of the anterior horn cell (HP:0006802)2.11328768
100Degeneration of anterior horn cells (HP:0002398)2.11328768
101Facial hemangioma (HP:0000329)2.09022847
102Ectopic kidney (HP:0000086)2.07498096
103Elevated erythrocyte sedimentation rate (HP:0003565)2.06990850
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06526190
105Abnormal protein N-linked glycosylation (HP:0012347)2.06526190
106Abnormal protein glycosylation (HP:0012346)2.06526190
107Abnormal glycosylation (HP:0012345)2.06526190
108Abnormality of placental membranes (HP:0011409)2.06292668
109Amniotic constriction ring (HP:0009775)2.06292668
110Oral leukoplakia (HP:0002745)2.05417491
111Pulmonary fibrosis (HP:0002206)2.05224832
112Hypochromic microcytic anemia (HP:0004840)2.04397772
113Stillbirth (HP:0003826)2.03497675
114Prolonged neonatal jaundice (HP:0006579)2.03421969
115Abnormal trabecular bone morphology (HP:0100671)2.03203948
116Abnormality of the prostate (HP:0008775)2.01149194
117Sloping forehead (HP:0000340)2.00074132
118Keratoconjunctivitis sicca (HP:0001097)1.99920637
119IgM deficiency (HP:0002850)1.99900228
120Acute myeloid leukemia (HP:0004808)1.99779291
121Absent radius (HP:0003974)1.99133457
122Poor head control (HP:0002421)1.97750810
123Small epiphyses (HP:0010585)1.96960590
124Loss of speech (HP:0002371)1.95851486
125Sparse eyelashes (HP:0000653)1.92788680
126Abnormality of T cell physiology (HP:0011840)1.92528420
127Abnormality of glycolysis (HP:0004366)1.92070039
128Short thumb (HP:0009778)1.92015902
129Hepatosplenomegaly (HP:0001433)1.91606753
130Stomach cancer (HP:0012126)1.90654775
131Abnormality of renal resorption (HP:0011038)1.89884759
132Paralysis (HP:0003470)1.89224729
133X-linked dominant inheritance (HP:0001423)1.88708352
134Abnormality of methionine metabolism (HP:0010901)1.88073120
135Hypoplasia of the fovea (HP:0007750)1.87281299
136Aplasia/Hypoplasia of the fovea (HP:0008060)1.87281299
137Aplasia/Hypoplasia involving the musculature (HP:0001460)1.85442458
138Exertional dyspnea (HP:0002875)1.85428245
139Delayed epiphyseal ossification (HP:0002663)1.84042417
140Aplasia involving forearm bones (HP:0009822)1.83972013
141Absent forearm bone (HP:0003953)1.83972013
142Abnormal delayed hypersensitivity skin test (HP:0002963)1.83750555
143Steatorrhea (HP:0002570)1.83635944
144Breast aplasia (HP:0100783)1.82624021
145Abnormality of the labia minora (HP:0012880)1.82509928
146Acute hepatic failure (HP:0006554)1.82428259
147CNS demyelination (HP:0007305)1.82218900
148Optic disc pallor (HP:0000543)1.82053955
149Eczematoid dermatitis (HP:0000976)1.81602317
150Aplasia/Hypoplasia of the breasts (HP:0010311)1.80902285
151Gangrene (HP:0100758)1.80763702
152Keratoconjunctivitis (HP:0001096)1.79985523
153Anorexia (HP:0002039)1.79793542
154Increased muscle lipid content (HP:0009058)1.78254675
155Type I transferrin isoform profile (HP:0003642)1.77857093
156Increased IgM level (HP:0003496)1.77825190
157Supernumerary spleens (HP:0009799)1.77742670
158Reticulocytopenia (HP:0001896)1.77274601
159Cleft eyelid (HP:0000625)1.77249103
160Petechiae (HP:0000967)1.76817810
161Abnormality of the fetal cardiovascular system (HP:0010948)1.76339677
162Abnormal umbilical cord blood vessels (HP:0011403)1.76339677
163Single umbilical artery (HP:0001195)1.76339677
164Abnormal gallbladder physiology (HP:0012438)1.75101275
165Cholecystitis (HP:0001082)1.75101275
166Breast carcinoma (HP:0003002)1.74783389
167Mediastinal lymphadenopathy (HP:0100721)1.74610324
168Irregular vertebral endplates (HP:0003301)1.73396633
169Abnormality of the heme biosynthetic pathway (HP:0010472)1.73249581
170Infertility (HP:0000789)1.72834792
171CNS hypomyelination (HP:0003429)1.72816323
172Autoimmune hemolytic anemia (HP:0001890)1.72684258
173Methylmalonic acidemia (HP:0002912)1.69249469
174Abnormal biliary tract physiology (HP:0012439)1.68901039
175Bile duct proliferation (HP:0001408)1.68901039
176Albinism (HP:0001022)1.68203611
177Reduced antithrombin III activity (HP:0001976)1.67633027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.54780212
2ACVR1B3.47991319
3PLK43.29810016
4SIK33.16220213
5EIF2AK13.11271296
6CDC73.01663747
7BUB12.94673229
8WEE12.70897615
9STK162.55618355
10TTK2.43085813
11SRPK12.40645031
12MUSK2.29857928
13BRSK22.18045612
14PBK2.08284936
15BRAF2.01756301
16EPHA21.84885055
17VRK11.76068550
18PLK11.75605015
19MAP3K61.75416278
20EIF2AK31.75132848
21PDK21.68471544
22NLK1.65430194
23VRK21.65149834
24NEK21.57520556
25CDK81.57398848
26STK101.52848689
27IRAK41.52778307
28PIM21.49099162
29ARAF1.47789732
30BMPR21.46060408
31CDK191.44036095
32MST41.35313536
33EIF2AK21.33621943
34ERBB41.31571934
35CHEK21.30786656
36PLK31.29332900
37ERBB31.24050637
38TXK1.22598121
39BMPR1B1.21956503
40AURKB1.20618268
41STK38L1.20069521
42MELK1.18806017
43MKNK11.18654498
44NME21.17660562
45MAP3K141.16665048
46MAPKAPK51.16549969
47DYRK31.14078918
48DYRK21.12881736
49BRSK11.08204047
50RPS6KA41.07436882
51ZAK1.04839633
52CCNB11.03692034
53TAOK31.03312308
54STK31.02441615
55TEC1.01287597
56IRAK21.00871757
57IKBKE1.00112467
58TRPM70.99508896
59MKNK20.98679572
60IKBKB0.98310616
61NUAK10.95819399
62AURKA0.95649666
63MAP4K10.95540395
64JAK30.95481726
65IRAK10.94962879
66ATR0.94758515
67NEK90.92830608
68MAP2K30.91984063
69TSSK60.91032075
70MAP3K50.90843083
71TGFBR10.89274873
72GRK70.86128541
73CDK70.84176689
74IRAK30.82812632
75PIM10.81984414
76MAPK130.81458853
77TAOK20.80877092
78INSRR0.80757449
79CHUK0.80105567
80RAF10.79805601
81KIT0.78629756
82OXSR10.77044278
83MOS0.77003004
84NME10.75474337
85KDR0.75213782
86ABL20.74741136
87BCKDK0.74317571
88STK40.73882913
89PASK0.68865682
90LATS10.67421431
91CHEK10.66443734
92FGR0.60247758
93CLK10.60091929
94MAP3K80.59930695
95STK240.59363931
96ATM0.56271527
97RPS6KB20.55577038
98MAP3K120.55271685
99TNIK0.55246005
100TESK20.54950161
101GRK60.54916543
102RPS6KA50.54617343
103TBK10.54499822
104TESK10.52928905
105MYLK0.52795852
106MAPKAPK30.52155222
107CSNK2A10.52046435
108MAP3K110.51374957
109BTK0.51331052
110TYK20.51304893
111ZAP700.49976221
112PIK3CG0.49715993
113CSK0.48897064
114RIPK40.48702511
115NEK10.47313338
116LYN0.44993022
117MATK0.44272587
118MAP3K30.42447559
119PAK40.41920583
120PINK10.41698035
121TLK10.41597989
122NEK60.41552539
123PAK10.40858121
124TNK20.40633245
125BCR0.40601836
126BLK0.40570818
127HCK0.40351423
128CDK30.39823188
129MARK30.39775281
130TAOK10.39577160
131LATS20.37841426
132STK390.37810954
133WNK30.37754206
134PLK20.36333515
135GRK10.36116432
136PRKCI0.35075754
137CSF1R0.32870731
138OBSCN0.32556472
139KSR10.31534634
140YES10.30892190
141DYRK1B0.30217183
142CSNK1G30.29487379
143CSNK2A20.29392427

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.77063101
2RNA polymerase_Homo sapiens_hsa030203.55654041
3Mismatch repair_Homo sapiens_hsa034303.46740750
4Proteasome_Homo sapiens_hsa030503.46409233
5Homologous recombination_Homo sapiens_hsa034403.43471084
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.14821394
7Basal transcription factors_Homo sapiens_hsa030223.07362088
8Cell cycle_Homo sapiens_hsa041102.80478365
9Oxidative phosphorylation_Homo sapiens_hsa001902.79521857
10Base excision repair_Homo sapiens_hsa034102.63500602
11RNA degradation_Homo sapiens_hsa030182.55939339
12Nucleotide excision repair_Homo sapiens_hsa034202.46772614
13Fanconi anemia pathway_Homo sapiens_hsa034602.37782093
14Parkinsons disease_Homo sapiens_hsa050122.37277884
15RNA transport_Homo sapiens_hsa030132.34001210
16Pyrimidine metabolism_Homo sapiens_hsa002402.29965593
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.19135311
18Spliceosome_Homo sapiens_hsa030402.14328796
19Protein export_Homo sapiens_hsa030601.92894067
20Non-homologous end-joining_Homo sapiens_hsa034501.92837812
21Vitamin B6 metabolism_Homo sapiens_hsa007501.86967026
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.67141304
23p53 signaling pathway_Homo sapiens_hsa041151.58652892
24Fatty acid elongation_Homo sapiens_hsa000621.55173715
25Purine metabolism_Homo sapiens_hsa002301.49605777
26Ribosome_Homo sapiens_hsa030101.41338861
27Collecting duct acid secretion_Homo sapiens_hsa049661.40041687
28Alzheimers disease_Homo sapiens_hsa050101.26656533
29Allograft rejection_Homo sapiens_hsa053301.26284244
30Herpes simplex infection_Homo sapiens_hsa051681.22640173
31Propanoate metabolism_Homo sapiens_hsa006401.21594961
32Epstein-Barr virus infection_Homo sapiens_hsa051691.18294535
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18207968
34Other glycan degradation_Homo sapiens_hsa005111.16586297
35mRNA surveillance pathway_Homo sapiens_hsa030151.12628593
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11465192
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.07609280
38Primary immunodeficiency_Homo sapiens_hsa053401.03418907
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.03292535
40Legionellosis_Homo sapiens_hsa051341.02457225
41Graft-versus-host disease_Homo sapiens_hsa053321.02010052
42One carbon pool by folate_Homo sapiens_hsa006700.98973552
43NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95369217
44Antigen processing and presentation_Homo sapiens_hsa046120.95360160
45Measles_Homo sapiens_hsa051620.94723677
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89775564
47Osteoclast differentiation_Homo sapiens_hsa043800.89313367
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88912050
49Leishmaniasis_Homo sapiens_hsa051400.88495515
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83582633
51Folate biosynthesis_Homo sapiens_hsa007900.81376687
52Ether lipid metabolism_Homo sapiens_hsa005650.81218206
53Asthma_Homo sapiens_hsa053100.81188558
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79981432
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79734732
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77996724
57Staphylococcus aureus infection_Homo sapiens_hsa051500.76790450
58Hematopoietic cell lineage_Homo sapiens_hsa046400.76024502
59Sulfur metabolism_Homo sapiens_hsa009200.74262128
60Influenza A_Homo sapiens_hsa051640.73804561
61Arachidonic acid metabolism_Homo sapiens_hsa005900.73247832
62Linoleic acid metabolism_Homo sapiens_hsa005910.72603925
63Oocyte meiosis_Homo sapiens_hsa041140.70959902
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70522380
65Autoimmune thyroid disease_Homo sapiens_hsa053200.70373967
66Malaria_Homo sapiens_hsa051440.66912254
67Salmonella infection_Homo sapiens_hsa051320.66746872
68Sphingolipid metabolism_Homo sapiens_hsa006000.66581031
69Rheumatoid arthritis_Homo sapiens_hsa053230.66063753
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66001714
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63786412
72Carbon metabolism_Homo sapiens_hsa012000.63286897
73Pentose phosphate pathway_Homo sapiens_hsa000300.63183479
74Regulation of autophagy_Homo sapiens_hsa041400.61141494
75Viral myocarditis_Homo sapiens_hsa054160.60565858
76Viral carcinogenesis_Homo sapiens_hsa052030.58808098
77Glutathione metabolism_Homo sapiens_hsa004800.57799469
78Shigellosis_Homo sapiens_hsa051310.57771674
79Apoptosis_Homo sapiens_hsa042100.57688039
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57206565
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57094560
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54387996
83African trypanosomiasis_Homo sapiens_hsa051430.53786282
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.53211431
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52846913
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52319028
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52291912
88Steroid biosynthesis_Homo sapiens_hsa001000.51550907
89Hepatitis B_Homo sapiens_hsa051610.51314195
90Vibrio cholerae infection_Homo sapiens_hsa051100.51257850
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51003918
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.50117261
93Type I diabetes mellitus_Homo sapiens_hsa049400.48681631
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48592454
95HTLV-I infection_Homo sapiens_hsa051660.48364164
96Peroxisome_Homo sapiens_hsa041460.48331684
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.47644344
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.47085327
99TNF signaling pathway_Homo sapiens_hsa046680.46819911
100Mineral absorption_Homo sapiens_hsa049780.46413254
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46215032
102TGF-beta signaling pathway_Homo sapiens_hsa043500.46146336
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45504057
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44516386
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44280295
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43856178
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43403372
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42960162
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.41954835
110Pancreatic cancer_Homo sapiens_hsa052120.41847133
111Huntingtons disease_Homo sapiens_hsa050160.39540519
112Circadian rhythm_Homo sapiens_hsa047100.39449536
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38593872
114MicroRNAs in cancer_Homo sapiens_hsa052060.35836440
115Phagosome_Homo sapiens_hsa041450.35812147
116Selenocompound metabolism_Homo sapiens_hsa004500.35696480
117Ovarian steroidogenesis_Homo sapiens_hsa049130.35028181
118Pertussis_Homo sapiens_hsa051330.33181741
119Tuberculosis_Homo sapiens_hsa051520.27509501
120Toxoplasmosis_Homo sapiens_hsa051450.25426752
121Systemic lupus erythematosus_Homo sapiens_hsa053220.24308570
122Colorectal cancer_Homo sapiens_hsa052100.24157101
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22955543
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22916985
125Metabolic pathways_Homo sapiens_hsa011000.22780699
126Thyroid cancer_Homo sapiens_hsa052160.19743153
127FoxO signaling pathway_Homo sapiens_hsa040680.19727910
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18324330

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