OSGEPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.34645546
2DNA double-strand break processing (GO:0000729)4.91321043
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.88060778
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.85168626
5ATP synthesis coupled proton transport (GO:0015986)4.85168626
6tricarboxylic acid cycle (GO:0006099)4.53242182
7respiratory electron transport chain (GO:0022904)4.46254748
8electron transport chain (GO:0022900)4.33217291
9mitochondrial respiratory chain complex I assembly (GO:0032981)4.24879819
10NADH dehydrogenase complex assembly (GO:0010257)4.24879819
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.24879819
12regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.05350900
13L-methionine biosynthetic process (GO:0071265)4.04915449
14amino acid salvage (GO:0043102)4.04915449
15L-methionine salvage (GO:0071267)4.04915449
16regulation of acyl-CoA biosynthetic process (GO:0050812)3.97473582
17oxidative phosphorylation (GO:0006119)3.96737292
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.94864619
19L-phenylalanine catabolic process (GO:0006559)3.85308207
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.85308207
21ubiquinone biosynthetic process (GO:0006744)3.84114965
22quinone biosynthetic process (GO:1901663)3.84114965
23L-phenylalanine metabolic process (GO:0006558)3.81791021
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.81791021
25NADH metabolic process (GO:0006734)3.79981496
26protein complex biogenesis (GO:0070271)3.78619817
27regulation of coenzyme metabolic process (GO:0051196)3.64244079
28regulation of cofactor metabolic process (GO:0051193)3.64244079
29presynaptic membrane assembly (GO:0097105)3.61053217
30glyoxylate metabolic process (GO:0046487)3.59711873
31replication fork processing (GO:0031297)3.59665965
32lysine catabolic process (GO:0006554)3.59451868
33lysine metabolic process (GO:0006553)3.59451868
34mitochondrial respiratory chain complex assembly (GO:0033108)3.56723360
35aspartate family amino acid catabolic process (GO:0009068)3.53858179
36ubiquinone metabolic process (GO:0006743)3.51317960
37branched-chain amino acid catabolic process (GO:0009083)3.50759983
38regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.50345543
39regulation of mitotic spindle checkpoint (GO:1903504)3.50345543
40nonmotile primary cilium assembly (GO:0035058)3.49581911
41respiratory chain complex IV assembly (GO:0008535)3.48694701
42cullin deneddylation (GO:0010388)3.47688737
43somatic hypermutation of immunoglobulin genes (GO:0016446)3.37390851
44somatic diversification of immune receptors via somatic mutation (GO:0002566)3.37390851
45presynaptic membrane organization (GO:0097090)3.35721152
46aerobic respiration (GO:0009060)3.31779856
47negative regulation of DNA-dependent DNA replication (GO:2000104)3.30204773
48aromatic amino acid family catabolic process (GO:0009074)3.28908816
49water-soluble vitamin biosynthetic process (GO:0042364)3.27495309
50proteasome assembly (GO:0043248)3.25125632
51cellular ketone body metabolic process (GO:0046950)3.24199834
52DNA catabolic process, exonucleolytic (GO:0000738)3.24076506
53protein deneddylation (GO:0000338)3.23719951
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.21692400
55succinate metabolic process (GO:0006105)3.18732747
56regulation of mitochondrial translation (GO:0070129)3.17258047
57regulation of sulfur metabolic process (GO:0042762)3.16394990
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16309835
59nucleotide-excision repair, DNA gap filling (GO:0006297)3.16023953
60cysteine metabolic process (GO:0006534)3.13203195
61positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.10401587
62mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.10401587
63fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.10042442
64lactate metabolic process (GO:0006089)3.08857234
65DNA damage response, detection of DNA damage (GO:0042769)3.07849022
66short-chain fatty acid metabolic process (GO:0046459)3.06603077
67serine family amino acid catabolic process (GO:0009071)3.06355625
68fatty acid beta-oxidation (GO:0006635)3.05826040
69mismatch repair (GO:0006298)3.05541257
70recombinational repair (GO:0000725)3.05473911
71chromatin remodeling at centromere (GO:0031055)3.05134399
72oxaloacetate metabolic process (GO:0006107)3.03773705
732-oxoglutarate metabolic process (GO:0006103)3.03688198
74inner mitochondrial membrane organization (GO:0007007)3.02895525
75maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02844117
76serine family amino acid biosynthetic process (GO:0009070)3.02246855
77double-strand break repair via homologous recombination (GO:0000724)3.02164777
78cytochrome complex assembly (GO:0017004)3.01569963
79telomere maintenance via semi-conservative replication (GO:0032201)3.01553921
80establishment of protein localization to mitochondrial membrane (GO:0090151)3.00045562
81protein neddylation (GO:0045116)3.00026042
82regulation of meiosis I (GO:0060631)2.98212489
83cellular respiration (GO:0045333)2.96576096
84tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96304763
85RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96304763
86intraciliary transport (GO:0042073)2.96221078
87acetyl-CoA metabolic process (GO:0006084)2.95004455
88serine family amino acid metabolic process (GO:0009069)2.94246752
89resolution of meiotic recombination intermediates (GO:0000712)2.93862415
90amino-acid betaine metabolic process (GO:0006577)2.92506845
91bile acid biosynthetic process (GO:0006699)2.90976033
92tryptophan catabolic process (GO:0006569)2.90971825
93indole-containing compound catabolic process (GO:0042436)2.90971825
94indolalkylamine catabolic process (GO:0046218)2.90971825
95sulfur amino acid biosynthetic process (GO:0000097)2.90550018
96ATP biosynthetic process (GO:0006754)2.88833519
97S-adenosylmethionine metabolic process (GO:0046500)2.88749969
98positive regulation of mitochondrial fission (GO:0090141)2.87999771
99methionine metabolic process (GO:0006555)2.87571120
100organelle disassembly (GO:1903008)2.87469529
101branched-chain amino acid metabolic process (GO:0009081)2.86366711
102methionine biosynthetic process (GO:0009086)2.86118827
103CENP-A containing nucleosome assembly (GO:0034080)2.85773422
104fatty acid catabolic process (GO:0009062)2.85480725
105glycine metabolic process (GO:0006544)2.84648396
106ketone body metabolic process (GO:1902224)2.81378371
107limb bud formation (GO:0060174)2.79757460
108aspartate family amino acid metabolic process (GO:0009066)2.78644137
109aspartate family amino acid biosynthetic process (GO:0009067)2.78559639
110detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.78544748
111quinone metabolic process (GO:1901661)2.77076973
112regulation of double-strand break repair via homologous recombination (GO:0010569)2.77011527
113histone H2A acetylation (GO:0043968)2.76946719
114fatty acid oxidation (GO:0019395)2.76668489
115centriole replication (GO:0007099)2.75691000
116spliceosomal complex assembly (GO:0000245)2.75200442
117coenzyme catabolic process (GO:0009109)2.74750968
118purine nucleoside triphosphate biosynthetic process (GO:0009145)2.72914116
119tryptophan metabolic process (GO:0006568)2.72856161
120histone mRNA metabolic process (GO:0008334)2.72780790
121alpha-amino acid catabolic process (GO:1901606)2.72627180
122kynurenine metabolic process (GO:0070189)2.72492482
123L-serine metabolic process (GO:0006563)2.72487732
124iron-sulfur cluster assembly (GO:0016226)2.72432852
125metallo-sulfur cluster assembly (GO:0031163)2.72432852
126telomere maintenance via recombination (GO:0000722)2.70679754
127RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.69555795
128lipid oxidation (GO:0034440)2.67799190
129purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.67735697
130neural tube formation (GO:0001841)2.67355247
131histone exchange (GO:0043486)2.66812537
132mitotic recombination (GO:0006312)2.66074392
133rRNA modification (GO:0000154)2.63355399
134regulation of sarcomere organization (GO:0060297)2.62340895
135peptidyl-histidine modification (GO:0018202)2.61803553
136DNA-dependent DNA replication (GO:0006261)2.59468322
137protoporphyrinogen IX metabolic process (GO:0046501)2.59109403
138sarcomere organization (GO:0045214)2.58252568
139aromatic amino acid family metabolic process (GO:0009072)2.58150146
140negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.57386059
141negative regulation of translation, ncRNA-mediated (GO:0040033)2.57386059
142regulation of translation, ncRNA-mediated (GO:0045974)2.57386059
143telomere maintenance via telomere lengthening (GO:0010833)2.56807272
144response to pheromone (GO:0019236)2.56798560
145mitochondrial DNA replication (GO:0006264)2.56782733
146monocarboxylic acid catabolic process (GO:0072329)2.56771486
147protoporphyrinogen IX biosynthetic process (GO:0006782)2.56666037
148heme transport (GO:0015886)2.56519988
149heart process (GO:0003015)2.56343225
150heart contraction (GO:0060047)2.56343225
151cellular amino acid catabolic process (GO:0009063)2.55659086
152protein-cofactor linkage (GO:0018065)2.55628442
153postreplication repair (GO:0006301)2.55074028
154chaperone-mediated protein transport (GO:0072321)2.54561665
155preassembly of GPI anchor in ER membrane (GO:0016254)2.54250615
156regulation of cilium movement (GO:0003352)2.54221354
157negative regulation of transcription regulatory region DNA binding (GO:2000678)2.53357685
158sequestering of actin monomers (GO:0042989)2.51936749
159cilium organization (GO:0044782)2.51335899
160epithelial cilium movement (GO:0003351)2.49397328
161DNA ligation (GO:0006266)2.49321218
162negative regulation of DNA recombination (GO:0045910)2.49291117
163DNA replication checkpoint (GO:0000076)2.48930919
164cilium assembly (GO:0042384)2.47745436
165regulation of glucokinase activity (GO:0033131)2.47119838
166regulation of hexokinase activity (GO:1903299)2.47119838
167reciprocal meiotic recombination (GO:0007131)2.46687452
168reciprocal DNA recombination (GO:0035825)2.46687452
169protein K6-linked ubiquitination (GO:0085020)2.46582617
170DNA strand elongation involved in DNA replication (GO:0006271)2.46283235
171kinetochore organization (GO:0051383)2.46230660
172cerebral cortex radially oriented cell migration (GO:0021799)2.44990821
173cilium morphogenesis (GO:0060271)2.44925867
174ribonucleoprotein complex disassembly (GO:0032988)2.44341393
175tongue development (GO:0043586)2.43810862
176regulation of DNA endoreduplication (GO:0032875)2.41527071
177retinal cone cell development (GO:0046549)2.38226870
178maturation of 5.8S rRNA (GO:0000460)2.37102181
179regulation of nuclear cell cycle DNA replication (GO:0033262)2.36718733
180regulation of development, heterochronic (GO:0040034)2.35946354
181neuron cell-cell adhesion (GO:0007158)2.35775757
182pyrimidine nucleobase catabolic process (GO:0006208)2.34636646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.44481043
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.50091221
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.42104950
4* EST1_17652178_ChIP-ChIP_JURKAT_Human3.22993435
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17559386
6* GABP_17652178_ChIP-ChIP_JURKAT_Human3.06401602
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.78901843
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71289659
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.69315385
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.67133970
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.59727004
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57793028
13PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.50232736
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43688432
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.43022937
16IGF1R_20145208_ChIP-Seq_DFB_Human2.41657146
17* SRF_21415370_ChIP-Seq_HL-1_Mouse2.41651237
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34281716
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.27600423
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.15723560
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15567917
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11435224
23IRF1_19129219_ChIP-ChIP_H3396_Human2.10563746
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.08778858
25TAF15_26573619_Chip-Seq_HEK293_Human2.03942000
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98425334
27RXR_22158963_ChIP-Seq_LIVER_Mouse1.93355101
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88959332
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85456516
30* FLI1_27457419_Chip-Seq_LIVER_Mouse1.83082553
31VDR_23849224_ChIP-Seq_CD4+_Human1.83052571
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.77261262
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76713128
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76547074
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74960585
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73662722
37DCP1A_22483619_ChIP-Seq_HELA_Human1.71089460
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69752844
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67323647
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66165956
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.65184898
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63366012
43FUS_26573619_Chip-Seq_HEK293_Human1.62752047
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61674076
45FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.60088666
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56610736
47* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54969416
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54685607
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53179380
50* FOXP3_21729870_ChIP-Seq_TREG_Human1.52024278
51* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47827122
52CBP_20019798_ChIP-Seq_JUKART_Human1.46469947
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46469947
54HTT_18923047_ChIP-ChIP_STHdh_Human1.46224190
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45670928
56GBX2_23144817_ChIP-Seq_PC3_Human1.45475626
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44050475
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42642302
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41210753
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38992730
61VDR_22108803_ChIP-Seq_LS180_Human1.37919232
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37385204
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37149519
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37041762
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35091972
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34611942
67AR_21909140_ChIP-Seq_LNCAP_Human1.33836705
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33825798
69* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32188757
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32083143
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30583601
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29605037
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28970162
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28433834
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28363715
76LXR_22158963_ChIP-Seq_LIVER_Mouse1.27859466
77BCAT_22108803_ChIP-Seq_LS180_Human1.27036219
78SMAD4_21799915_ChIP-Seq_A2780_Human1.25595376
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25070512
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24372666
81TP53_22573176_ChIP-Seq_HFKS_Human1.24049341
82* ELK1_19687146_ChIP-ChIP_HELA_Human1.22989906
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21907947
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.20474847
85GABP_19822575_ChIP-Seq_HepG2_Human1.20182840
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.19760681
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18327469
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18101274
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18004284
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16636497
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15260002
92* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13973807
93AR_25329375_ChIP-Seq_VCAP_Human1.13185085
94AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13128887
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12337530
96E2F7_22180533_ChIP-Seq_HELA_Human1.12002012
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11624121
98MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11437886
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10801865
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.10059786
101* NFE2_27457419_Chip-Seq_LIVER_Mouse1.08984965
102MYC_18940864_ChIP-ChIP_HL60_Human1.08619524
103SOX2_16153702_ChIP-ChIP_HESCs_Human1.06478453
104* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.06416231
105* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06305405
106FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05510928
107STAT3_23295773_ChIP-Seq_U87_Human1.05399900
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04599220
109XRN2_22483619_ChIP-Seq_HELA_Human1.03396328
110ZNF274_21170338_ChIP-Seq_K562_Hela1.03016919
111TCF4_23295773_ChIP-Seq_U87_Human1.01172226
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.00868125
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00478510
114EZH2_22144423_ChIP-Seq_EOC_Human1.00452811
115TTF2_22483619_ChIP-Seq_HELA_Human1.00441343
116ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99879281
117ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99600440
118SOX2_19829295_ChIP-Seq_ESCs_Human0.99236546
119NANOG_19829295_ChIP-Seq_ESCs_Human0.99236546
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98319186
121CBX2_27304074_Chip-Seq_ESCs_Mouse0.97232021
122RNF2_27304074_Chip-Seq_NSC_Mouse0.97206317
123TCF4_22108803_ChIP-Seq_LS180_Human0.97050905
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96813209
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96718368
126ER_23166858_ChIP-Seq_MCF-7_Human0.95868317
127MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95373798
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94597530
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94597530
130E2F1_21310950_ChIP-Seq_MCF-7_Human0.94503549
131RUNX2_22187159_ChIP-Seq_PCA_Human0.93034693
132* EZH2_27294783_Chip-Seq_NPCs_Mouse0.91942760
133* CRX_20693478_ChIP-Seq_RETINA_Mouse0.88721879
134GATA4_21415370_ChIP-Seq_HL-1_Mouse0.87711749
135HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87257792
136CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86891797
137POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85499600
138* SOX17_20123909_ChIP-Seq_XEN_Mouse0.84786677
139MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84284333
140POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83176726
141EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82332384
142P300_19829295_ChIP-Seq_ESCs_Human0.80794150
143ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78247458
144* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.78149766
145CIITA_25753668_ChIP-Seq_RAJI_Human0.77582271
146EWS_26573619_Chip-Seq_HEK293_Human0.77131466
147MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.77121276
148* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.74486972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.34731000
2MP0002139_abnormal_hepatobiliary_system4.20985982
3MP0005085_abnormal_gallbladder_physiolo3.87608850
4MP0003806_abnormal_nucleotide_metabolis3.59577412
5MP0002837_dystrophic_cardiac_calcinosis3.51311266
6MP0005360_urolithiasis3.43544793
7MP0005365_abnormal_bile_salt3.17717594
8MP0000749_muscle_degeneration3.02750222
9MP0004147_increased_porphyrin_level3.01966126
10MP0004215_abnormal_myocardial_fiber2.90757418
11MP0008789_abnormal_olfactory_epithelium2.87737377
12MP0006036_abnormal_mitochondrial_physio2.86303414
13MP0003880_abnormal_central_pattern2.62246719
14MP0008875_abnormal_xenobiotic_pharmacok2.52794502
15MP0003950_abnormal_plasma_membrane2.43530712
16MP0004036_abnormal_muscle_relaxation2.43176446
17MP0000566_synostosis2.33791140
18MP0004084_abnormal_cardiac_muscle2.33599665
19MP0005394_taste/olfaction_phenotype2.30068714
20MP0005499_abnormal_olfactory_system2.30068714
21MP0006035_abnormal_mitochondrial_morpho2.26674167
22MP0000751_myopathy2.11881566
23MP0005330_cardiomyopathy2.10115545
24MP0004145_abnormal_muscle_electrophysio2.00937072
25MP0005332_abnormal_amino_acid2.00008925
26MP0003195_calcinosis1.98149385
27MP0003121_genomic_imprinting1.87241553
28MP0003656_abnormal_erythrocyte_physiolo1.84657195
29MP0009697_abnormal_copulation1.82115126
30MP0005253_abnormal_eye_physiology1.79292082
31MP0001529_abnormal_vocalization1.76481797
32MP0010030_abnormal_orbit_morphology1.75388368
33MP0001293_anophthalmia1.68736902
34MP0005248_abnormal_Harderian_gland1.63788252
35MP0003787_abnormal_imprinting1.63367676
36MP0000631_abnormal_neuroendocrine_gland1.63245282
37MP0002638_abnormal_pupillary_reflex1.61141913
38MP0003122_maternal_imprinting1.60933711
39MP0003718_maternal_effect1.60484274
40MP0003890_abnormal_embryonic-extraembry1.59321172
41MP0001764_abnormal_homeostasis1.58509156
42MP0003252_abnormal_bile_duct1.54286819
43MP0002269_muscular_atrophy1.53155791
44MP0005620_abnormal_muscle_contractility1.52583079
45MP0002233_abnormal_nose_morphology1.47129205
46MP0005646_abnormal_pituitary_gland1.45625478
47MP0000778_abnormal_nervous_system1.45606169
48MP0003221_abnormal_cardiomyocyte_apopto1.44970904
49MP0002127_abnormal_cardiovascular_syste1.44654609
50MP0000372_irregular_coat_pigmentation1.44473489
51MP0008995_early_reproductive_senescence1.42630199
52MP0002736_abnormal_nociception_after1.40395161
53MP0002972_abnormal_cardiac_muscle1.40049253
54MP0002751_abnormal_autonomic_nervous1.39118964
55MP0005083_abnormal_biliary_tract1.37565996
56MP0003136_yellow_coat_color1.36792450
57MP0008775_abnormal_heart_ventricle1.36338014
58MP0003186_abnormal_redox_activity1.34075814
59MP0002234_abnormal_pharynx_morphology1.28759922
60MP0005187_abnormal_penis_morphology1.25438243
61MP0005084_abnormal_gallbladder_morpholo1.25171027
62MP0005670_abnormal_white_adipose1.24830645
63MP0004484_altered_response_of1.24582676
64MP0003937_abnormal_limbs/digits/tail_de1.21877124
65MP0004957_abnormal_blastocyst_morpholog1.19845606
66MP0000747_muscle_weakness1.19572200
67MP0003137_abnormal_impulse_conducting1.18148677
68MP0004087_abnormal_muscle_fiber1.17573684
69MP0006292_abnormal_olfactory_placode1.17362520
70MP0010329_abnormal_lipoprotein_level1.16823870
71MP0002653_abnormal_ependyma_morphology1.16122170
72MP0008058_abnormal_DNA_repair1.14624590
73MP0004085_abnormal_heartbeat1.12973438
74MP0005391_vision/eye_phenotype1.12491179
75MP0001666_abnormal_nutrient_absorption1.11452853
76MP0004043_abnormal_pH_regulation1.10821890
77MP0005266_abnormal_metabolism1.10524741
78MP0003693_abnormal_embryo_hatching1.09913412
79MP0000647_abnormal_sebaceous_gland1.08796249
80MP0000049_abnormal_middle_ear1.08553358
81MP0004130_abnormal_muscle_cell1.08316014
82MP0005551_abnormal_eye_electrophysiolog1.07456819
83MP0004142_abnormal_muscle_tone1.06771189
84MP0005367_renal/urinary_system_phenotyp1.04958928
85MP0000516_abnormal_urinary_system1.04958928
86MP0000427_abnormal_hair_cycle1.03504079
87MP0001544_abnormal_cardiovascular_syste1.03417534
88MP0005385_cardiovascular_system_phenoty1.03417534
89MP0004133_heterotaxia1.02307315
90MP0008260_abnormal_autophagy1.01802660
91MP0002106_abnormal_muscle_physiology1.01654761
92MP0010094_abnormal_chromosome_stability1.01534197
93MP0002272_abnormal_nervous_system1.00556706
94MP0006138_congestive_heart_failure1.00239868
95MP0001486_abnormal_startle_reflex0.98738890
96MP0003111_abnormal_nucleus_morphology0.98581009
97MP0005195_abnormal_posterior_eye0.98267189
98MP0003315_abnormal_perineum_morphology0.98064297
99MP0003938_abnormal_ear_development0.97768400
100MP0005171_absent_coat_pigmentation0.97645578
101MP0005410_abnormal_fertilization0.97228346
102MP0001188_hyperpigmentation0.96399680
103MP0003755_abnormal_palate_morphology0.96281993
104MP0008877_abnormal_DNA_methylation0.95853505
105MP0001968_abnormal_touch/_nociception0.95533431
106MP0003567_abnormal_fetal_cardiomyocyte0.93178010
107MP0001986_abnormal_taste_sensitivity0.93017400
108MP0005369_muscle_phenotype0.91432820
109MP0005451_abnormal_body_composition0.91308968
110MP0001929_abnormal_gametogenesis0.91040973
111MP0005075_abnormal_melanosome_morpholog0.90844338
112MP0002752_abnormal_somatic_nervous0.90429541
113MP0003119_abnormal_digestive_system0.89682295
114MP0009745_abnormal_behavioral_response0.88871096
115MP0002090_abnormal_vision0.88767569
116MP0002332_abnormal_exercise_endurance0.88130792
117MP0002184_abnormal_innervation0.87827244
118MP0000026_abnormal_inner_ear0.86311722
119MP0001286_abnormal_eye_development0.86292970
120MP0001905_abnormal_dopamine_level0.85276265
121MP0001145_abnormal_male_reproductive0.85064111
122MP0002118_abnormal_lipid_homeostasis0.84798180
123MP0003786_premature_aging0.84676091
124MP0005584_abnormal_enzyme/coenzyme_acti0.84195433
125MP0003868_abnormal_feces_composition0.84169929
126MP0008872_abnormal_physiological_respon0.83722973
127MP0004924_abnormal_behavior0.83061329
128MP0005386_behavior/neurological_phenoty0.83061329
129MP0005319_abnormal_enzyme/_coenzyme0.82226542
130MP0000759_abnormal_skeletal_muscle0.81732408
131MP0009379_abnormal_foot_pigmentation0.81357379
132MP0001324_abnormal_eye_pigmentation0.80598889
133MP0002132_abnormal_respiratory_system0.80204744
134MP0003698_abnormal_male_reproductive0.80126633
135MP0010630_abnormal_cardiac_muscle0.79457527
136MP0001177_atelectasis0.77240762
137MP0001485_abnormal_pinna_reflex0.77109428
138MP0005423_abnormal_somatic_nervous0.76196444
139MP0003861_abnormal_nervous_system0.76054533
140MP0000569_abnormal_digit_pigmentation0.75303354
141MP0002557_abnormal_social/conspecific_i0.75284468
142MP0005636_abnormal_mineral_homeostasis0.75126093
143MP0002229_neurodegeneration0.74029625
144MP0002210_abnormal_sex_determination0.73376474
145MP0001661_extended_life_span0.72616667
146MP0001984_abnormal_olfaction0.72453398
147MP0004233_abnormal_muscle_weight0.72006286
148MP0006276_abnormal_autonomic_nervous0.71876171
149MP0002102_abnormal_ear_morphology0.70502942
150MP0005645_abnormal_hypothalamus_physiol0.69444343
151MP0008057_abnormal_DNA_replication0.69310245
152MP0002938_white_spotting0.67858454
153MP0008932_abnormal_embryonic_tissue0.65870952
154MP0009046_muscle_twitch0.65068965
155MP0002160_abnormal_reproductive_system0.65064097
156MP0005376_homeostasis/metabolism_phenot0.63737659
157MP0000653_abnormal_sex_gland0.63096645
158MP0005535_abnormal_body_temperature0.63052451
159MP0006072_abnormal_retinal_apoptosis0.62694677
160MP0003077_abnormal_cell_cycle0.62160662
161MP0000609_abnormal_liver_physiology0.60581000

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.82271122
2Acute necrotizing encephalopathy (HP:0006965)4.76446173
3Acute encephalopathy (HP:0006846)4.52478904
4Abnormal mitochondria in muscle tissue (HP:0008316)4.52314142
5Abnormality of glycolysis (HP:0004366)4.24287562
6Increased serum pyruvate (HP:0003542)4.24287562
7Cerebral edema (HP:0002181)4.19458076
8Hepatic necrosis (HP:0002605)4.17921532
9Hepatocellular necrosis (HP:0001404)4.15731584
10Mitochondrial inheritance (HP:0001427)4.15092119
11Progressive macrocephaly (HP:0004481)4.13004904
12Muscle hypertrophy of the lower extremities (HP:0008968)3.97701869
13Increased CSF lactate (HP:0002490)3.87526843
14Calf muscle hypertrophy (HP:0008981)3.80158883
15Lactic acidosis (HP:0003128)3.37372737
16Hyperglycinemia (HP:0002154)3.25365670
17Hyperglycinuria (HP:0003108)3.24996570
18Lethargy (HP:0001254)3.17101366
19Intrahepatic cholestasis (HP:0001406)3.13935484
20Medial flaring of the eyebrow (HP:0010747)3.12748369
21Hyperalaninemia (HP:0003348)3.09912346
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.09912346
23Abnormality of alanine metabolism (HP:0010916)3.09912346
24True hermaphroditism (HP:0010459)3.02109882
25Pancreatic cysts (HP:0001737)3.00111354
26Abnormality of aromatic amino acid family metabolism (HP:0004338)2.98050810
27Abnormality of serine family amino acid metabolism (HP:0010894)2.97350514
28Abnormality of glycine metabolism (HP:0010895)2.97350514
29Abnormality of midbrain morphology (HP:0002418)2.92103079
30Molar tooth sign on MRI (HP:0002419)2.92103079
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.91559834
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.91559834
33Lipid accumulation in hepatocytes (HP:0006561)2.90190231
34Increased serum lactate (HP:0002151)2.88629722
35Abnormality of serum amino acid levels (HP:0003112)2.87280119
36Dicarboxylic aciduria (HP:0003215)2.85047185
37Abnormality of dicarboxylic acid metabolism (HP:0010995)2.85047185
38Ketosis (HP:0001946)2.82430147
39Abnormality of fatty-acid metabolism (HP:0004359)2.81966825
40Chromsome breakage (HP:0040012)2.76150196
41Increased intramyocellular lipid droplets (HP:0012240)2.73848547
42Increased hepatocellular lipid droplets (HP:0006565)2.72172945
43Myoglobinuria (HP:0002913)2.72158489
44Respiratory failure (HP:0002878)2.70214775
453-Methylglutaconic aciduria (HP:0003535)2.70027377
46Hyperammonemia (HP:0001987)2.69723276
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.68614661
48Pheochromocytoma (HP:0002666)2.68545305
49Increased muscle lipid content (HP:0009058)2.68086670
50Abnormality of chromosome stability (HP:0003220)2.67738105
51Exercise-induced muscle cramps (HP:0003710)2.67275010
52Exercise-induced myalgia (HP:0003738)2.65447363
53Hypoglycemic coma (HP:0001325)2.64929171
54Gait imbalance (HP:0002141)2.64649058
55Sudden death (HP:0001699)2.64545131
56Exercise intolerance (HP:0003546)2.63200257
57Congenital primary aphakia (HP:0007707)2.62463773
58Nephronophthisis (HP:0000090)2.60775669
59Ketoacidosis (HP:0001993)2.60126069
60Meckel diverticulum (HP:0002245)2.59294481
61Cystic liver disease (HP:0006706)2.58858336
62Abnormality of the heme biosynthetic pathway (HP:0010472)2.58451746
63Neuroendocrine neoplasm (HP:0100634)2.56464897
64Colon cancer (HP:0003003)2.56406506
65CNS demyelination (HP:0007305)2.56362785
66Abnormality of the ileum (HP:0001549)2.54469048
67Renal Fanconi syndrome (HP:0001994)2.53313661
68Genital tract atresia (HP:0001827)2.52478871
69Generalized aminoaciduria (HP:0002909)2.51738013
70Optic disc pallor (HP:0000543)2.48865052
71Aplasia/Hypoplasia of the tongue (HP:0010295)2.47759015
72Hypobetalipoproteinemia (HP:0003563)2.46889891
73Metabolic acidosis (HP:0001942)2.43388363
74Nephrogenic diabetes insipidus (HP:0009806)2.42220177
75Rhabdomyolysis (HP:0003201)2.40026774
76Gastrointestinal atresia (HP:0002589)2.36824298
77Birth length less than 3rd percentile (HP:0003561)2.33837816
78Type II lissencephaly (HP:0007260)2.32590480
79Leukodystrophy (HP:0002415)2.31969817
80Prolonged partial thromboplastin time (HP:0003645)2.31702045
81Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30737071
82Abnormality of urine glucose concentration (HP:0011016)2.29918507
83Glycosuria (HP:0003076)2.29918507
84Nausea (HP:0002018)2.29629578
85Vaginal atresia (HP:0000148)2.28302678
86Abnormality of monocarboxylic acid metabolism (HP:0010996)2.25272512
87Cerebral hypomyelination (HP:0006808)2.24812680
88Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24207355
89Intestinal atresia (HP:0011100)2.23873054
90Abnormality of the calf musculature (HP:0001430)2.22276454
91Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20125504
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.19256719
93Vomiting (HP:0002013)2.19113043
94Hypolipoproteinemia (HP:0010981)2.16987546
95Small hand (HP:0200055)2.16091856
96Ragged-red muscle fibers (HP:0003200)2.14782951
97Postaxial foot polydactyly (HP:0001830)2.14151450
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13652807
99Palpitations (HP:0001962)2.13236983
100Abnormality of methionine metabolism (HP:0010901)2.12464011
101Postaxial hand polydactyly (HP:0001162)2.10822279
102Optic nerve hypoplasia (HP:0000609)2.10797572
103Hypothermia (HP:0002045)2.10792810
104Febrile seizures (HP:0002373)2.10173560
105Atrial fibrillation (HP:0005110)2.09201516
106Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08553772
107Triphalangeal thumb (HP:0001199)2.07104277
108Abnormality of the renal medulla (HP:0100957)2.07069642
109Hypoalphalipoproteinemia (HP:0003233)2.06690501
110Volvulus (HP:0002580)2.06244518
111Hyperlipoproteinemia (HP:0010980)2.03764124
112Cerebellar dysplasia (HP:0007033)2.03276638
113Retinal dysplasia (HP:0007973)2.02496981
114Renal cortical cysts (HP:0000803)1.99290332
115Abnormal gallbladder morphology (HP:0012437)1.99244457
116Sclerocornea (HP:0000647)1.98966780
117Hyperbilirubinemia (HP:0002904)1.98752267
118Occipital encephalocele (HP:0002085)1.98604349
119Cholelithiasis (HP:0001081)1.98200004
120Abnormal gallbladder physiology (HP:0012438)1.97613984
121Cholecystitis (HP:0001082)1.97613984
122Methylmalonic aciduria (HP:0012120)1.97302619
123Ventricular tachycardia (HP:0004756)1.96587630
124Abnormality of the preputium (HP:0100587)1.96542642
125Tubulointerstitial nephritis (HP:0001970)1.96273705
126Conjugated hyperbilirubinemia (HP:0002908)1.94953526
127Septo-optic dysplasia (HP:0100842)1.94560952
128Sloping forehead (HP:0000340)1.94399060
129Abnormality of the metopic suture (HP:0005556)1.94161651
130Chronic hepatic failure (HP:0100626)1.93786097
131Lipoatrophy (HP:0100578)1.93736315
132Oligodactyly (HP:0012165)1.92512645
133Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91737358
134Poor coordination (HP:0002370)1.91266500
135Muscle fiber splitting (HP:0003555)1.90916127
136Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.90890352
137Methylmalonic acidemia (HP:0002912)1.90761229
138Abnormality of the vitamin B12 metabolism (HP:0004341)1.89951073
139Abnormality of vitamin B metabolism (HP:0004340)1.88892228
140Rib fusion (HP:0000902)1.88459633
141Small intestinal stenosis (HP:0012848)1.88115927
142Duodenal stenosis (HP:0100867)1.88115927
143Emotional lability (HP:0000712)1.87848654
144Glioma (HP:0009733)1.87397587
145Aplasia/Hypoplasia of the tibia (HP:0005772)1.87019446
146Esophageal atresia (HP:0002032)1.86607676
147Oligodactyly (hands) (HP:0001180)1.84955154
148Hypochromic microcytic anemia (HP:0004840)1.84468908
149Hyperventilation (HP:0002883)1.83551718
150Primary atrial arrhythmia (HP:0001692)1.82676292
151Abnormality of the duodenum (HP:0002246)1.82561729
152Abnormal lung lobation (HP:0002101)1.82366274
153Ectopic kidney (HP:0000086)1.82049605
154Supraventricular tachycardia (HP:0004755)1.81931802
155Ependymoma (HP:0002888)1.81801076
156Aplasia/Hypoplasia of the sternum (HP:0006714)1.81468426
157Dilated cardiomyopathy (HP:0001644)1.80621836
158Unsteady gait (HP:0002317)1.80475074
159Short tibia (HP:0005736)1.80205945
160Preaxial hand polydactyly (HP:0001177)1.79404025
161Abnormal biliary tract physiology (HP:0012439)1.79387190
162Bile duct proliferation (HP:0001408)1.79387190
163Astigmatism (HP:0000483)1.78560202
164Supernumerary spleens (HP:0009799)1.75054666
165Abolished electroretinogram (ERG) (HP:0000550)1.74556312
166Pancreatic fibrosis (HP:0100732)1.73624430
167Abnormality of the renal cortex (HP:0011035)1.72768071
168Abnormal spermatogenesis (HP:0008669)1.72704358
169Respiratory difficulties (HP:0002880)1.72604573
170Medulloblastoma (HP:0002885)1.71682241
171Anencephaly (HP:0002323)1.70755987
172Aganglionic megacolon (HP:0002251)1.70585801
173Dandy-Walker malformation (HP:0001305)1.69954951
174Hemivertebrae (HP:0002937)1.68164346
175Male pseudohermaphroditism (HP:0000037)1.67782271
176Decreased testicular size (HP:0008734)1.66005344

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN3.63711703
2BCKDK3.58443245
3STK163.47266141
4WNK33.10161267
5BUB12.97749736
6PDK32.91404929
7PDK42.91404929
8PRPF4B2.90650510
9EIF2AK12.87532264
10TRIM282.85215533
11FRK2.71231488
12MAP4K22.65451403
13LMTK22.65191623
14NUAK12.12700034
15CASK2.09129665
16STK38L2.08034093
17VRK12.04492452
18PINK12.02173049
19ERBB31.98783499
20NEK11.98629238
21PLK41.95292127
22VRK21.91897034
23LATS11.88920405
24BRSK21.83538775
25WEE11.76429405
26MAPK131.66143392
27MYLK1.66119323
28GRK71.62266970
29ZAK1.59007529
30PDK21.58658071
31INSRR1.58253671
32MKNK21.47642060
33SRPK11.46016982
34MUSK1.45785392
35NME11.42087969
36MST41.37360145
37EIF2AK31.35360570
38PLK31.31942544
39BRAF1.30511128
40PAK31.29972132
41CCNB11.29188355
42AKT31.29059300
43MAP2K71.22666586
44TAF11.20476129
45KDR1.20462939
46STK391.17199546
47CDK191.17006550
48STK241.12294826
49ACVR1B1.10945065
50OXSR11.08835760
51PHKG11.08132833
52PHKG21.08132833
53MARK11.07174644
54CSNK1G21.05973832
55MAP3K121.03140889
56ATR0.99536179
57TTK0.96938826
58NME20.96263648
59BCR0.96079761
60MKNK10.95284690
61TLK10.94211828
62ADRBK20.93399236
63EPHA40.89385031
64CSNK1A1L0.84578649
65PNCK0.82826296
66PLK10.81856129
67KSR10.80693866
68BRSK10.80360672
69PIK3CA0.80127263
70PBK0.79394225
71FLT30.79350618
72PLK20.79296738
73WNK40.74679073
74PRKCE0.73937101
75CDK80.73377437
76ATM0.73065437
77CAMK2D0.72365312
78TSSK60.71610839
79CDC70.70985088
80MAP3K40.69922647
81DYRK20.69765189
82RPS6KA40.69423406
83EPHB20.66767494
84PKN10.66481655
85IRAK20.66377024
86CDK30.66019637
87TNIK0.65154153
88CAMK2G0.65072155
89TTN0.63316136
90NLK0.63134661
91PRKAA10.62600625
92MINK10.62494651
93ERBB40.60031390
94NTRK20.59876189
95MAP2K40.58198972
96AURKA0.57414365
97CAMK2B0.56582269
98STK30.56041130
99AURKB0.54407877
100PRKAA20.54274702
101CAMK2A0.52285436
102CAMKK20.51982755
103TGFBR10.51563223
104NEK60.51218052
105CSNK1G30.50409895
106CSNK2A10.48298311
107PAK60.46926731
108NEK90.45624175
109PRKG10.44535251
110DYRK30.41817059
111PASK0.41797371
112RAF10.41720236
113PRKACA0.41166027
114FGFR10.40229843
115EIF2AK20.40226715
116CSNK1G10.39307166
117TIE10.39199290
118CSNK1E0.39015270
119PRKDC0.38037865
120CHEK20.37809671
121CSNK2A20.37792460
122LIMK10.37321403
123PTK2B0.37233827
124CLK10.36152925
125GRK10.35974936
126NEK20.35131375
127FGFR20.34601895
128SIK30.33094176
129SGK2230.31993257
130SGK4940.31993257
131STK40.31014811
132MAP3K110.30792451
133PRKACB0.29274320
134SGK20.26731640
135PRKCG0.26727131
136BMPR1B0.26516784

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.25478803
2Propanoate metabolism_Homo sapiens_hsa006403.09895742
3Oxidative phosphorylation_Homo sapiens_hsa001902.98935840
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73686703
5Parkinsons disease_Homo sapiens_hsa050122.64637847
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.55371854
7Pyruvate metabolism_Homo sapiens_hsa006202.41460788
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34122977
9Fatty acid degradation_Homo sapiens_hsa000712.29197031
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.22569272
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20292332
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.11160451
13Vitamin B6 metabolism_Homo sapiens_hsa007502.10210636
14Huntingtons disease_Homo sapiens_hsa050162.01250192
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99956166
16Proteasome_Homo sapiens_hsa030501.99360853
17Fatty acid elongation_Homo sapiens_hsa000621.91383537
18Carbon metabolism_Homo sapiens_hsa012001.89103346
19Butanoate metabolism_Homo sapiens_hsa006501.81244717
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80950881
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.74528680
22Alzheimers disease_Homo sapiens_hsa050101.73276883
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.70463402
24Fatty acid metabolism_Homo sapiens_hsa012121.69931523
25Cardiac muscle contraction_Homo sapiens_hsa042601.67533893
26Peroxisome_Homo sapiens_hsa041461.65290939
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62016156
28Phototransduction_Homo sapiens_hsa047441.59565682
29RNA polymerase_Homo sapiens_hsa030201.51601073
30Biosynthesis of amino acids_Homo sapiens_hsa012301.45933252
31DNA replication_Homo sapiens_hsa030301.41554615
32Tryptophan metabolism_Homo sapiens_hsa003801.39325528
33Folate biosynthesis_Homo sapiens_hsa007901.35927138
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30294906
35Basal transcription factors_Homo sapiens_hsa030221.27126929
36Arginine biosynthesis_Homo sapiens_hsa002201.26668603
37Protein export_Homo sapiens_hsa030601.26331845
38beta-Alanine metabolism_Homo sapiens_hsa004101.23920131
39Ribosome_Homo sapiens_hsa030101.21560892
40Pyrimidine metabolism_Homo sapiens_hsa002401.20748962
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20610743
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19727994
43Nucleotide excision repair_Homo sapiens_hsa034201.17197309
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15748775
45Sulfur metabolism_Homo sapiens_hsa009201.11475927
46Arginine and proline metabolism_Homo sapiens_hsa003301.10240311
47One carbon pool by folate_Homo sapiens_hsa006701.07187834
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07031077
49Selenocompound metabolism_Homo sapiens_hsa004501.06186483
50Homologous recombination_Homo sapiens_hsa034401.05429516
51Nicotine addiction_Homo sapiens_hsa050331.04209727
52Tyrosine metabolism_Homo sapiens_hsa003501.04068036
53Mismatch repair_Homo sapiens_hsa034301.03433216
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01619447
55Metabolic pathways_Homo sapiens_hsa011000.98761479
56Phenylalanine metabolism_Homo sapiens_hsa003600.97710639
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96954812
58PPAR signaling pathway_Homo sapiens_hsa033200.95877255
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.94659928
60Sulfur relay system_Homo sapiens_hsa041220.93685396
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89747010
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87411601
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87119607
64Purine metabolism_Homo sapiens_hsa002300.86205041
65Glutathione metabolism_Homo sapiens_hsa004800.85243846
66Circadian rhythm_Homo sapiens_hsa047100.84907323
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84063238
68Hedgehog signaling pathway_Homo sapiens_hsa043400.83033330
69mRNA surveillance pathway_Homo sapiens_hsa030150.82950387
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78503327
71Basal cell carcinoma_Homo sapiens_hsa052170.76983322
72Chemical carcinogenesis_Homo sapiens_hsa052040.76540809
73Regulation of autophagy_Homo sapiens_hsa041400.75719339
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74768802
75Olfactory transduction_Homo sapiens_hsa047400.73823184
76Oocyte meiosis_Homo sapiens_hsa041140.71835606
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71547740
78Retinol metabolism_Homo sapiens_hsa008300.71355741
79RNA transport_Homo sapiens_hsa030130.70811852
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.70805325
81Histidine metabolism_Homo sapiens_hsa003400.70445534
82Fructose and mannose metabolism_Homo sapiens_hsa000510.69426872
83Base excision repair_Homo sapiens_hsa034100.66550247
84Starch and sucrose metabolism_Homo sapiens_hsa005000.64388541
85Ether lipid metabolism_Homo sapiens_hsa005650.63989465
86Glycerolipid metabolism_Homo sapiens_hsa005610.63779575
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.63141737
88Taste transduction_Homo sapiens_hsa047420.61968164
89Complement and coagulation cascades_Homo sapiens_hsa046100.59569331
90Fat digestion and absorption_Homo sapiens_hsa049750.58156602
91RNA degradation_Homo sapiens_hsa030180.56866937
92Fanconi anemia pathway_Homo sapiens_hsa034600.54729185
93Pentose phosphate pathway_Homo sapiens_hsa000300.54513386
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53100237
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.52892234
96ABC transporters_Homo sapiens_hsa020100.52791886
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51883199
98Spliceosome_Homo sapiens_hsa030400.51641219
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48631024
100GABAergic synapse_Homo sapiens_hsa047270.47496246
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47431045
102p53 signaling pathway_Homo sapiens_hsa041150.47031535
103Collecting duct acid secretion_Homo sapiens_hsa049660.46807101
104Linoleic acid metabolism_Homo sapiens_hsa005910.46444997
105Nitrogen metabolism_Homo sapiens_hsa009100.44667367
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41971281
107Cell cycle_Homo sapiens_hsa041100.41749148
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40837565
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39616302
110Vitamin digestion and absorption_Homo sapiens_hsa049770.36199639
111Steroid biosynthesis_Homo sapiens_hsa001000.35187125
112Non-homologous end-joining_Homo sapiens_hsa034500.34556616
113Lysine degradation_Homo sapiens_hsa003100.34122870
114Caffeine metabolism_Homo sapiens_hsa002320.32256378
115Mineral absorption_Homo sapiens_hsa049780.31479742
116Wnt signaling pathway_Homo sapiens_hsa043100.31077461
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30711991
118Glutamatergic synapse_Homo sapiens_hsa047240.30683995
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30556139
120Serotonergic synapse_Homo sapiens_hsa047260.30314346
121Circadian entrainment_Homo sapiens_hsa047130.29776216
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28002882
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26813093
124Dilated cardiomyopathy_Homo sapiens_hsa054140.26724709
125Bile secretion_Homo sapiens_hsa049760.26685368
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.26635117
127Glucagon signaling pathway_Homo sapiens_hsa049220.25463309

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