OSGIN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.54325444
2detection of molecule of bacterial origin (GO:0032490)4.25211859
3neutrophil activation involved in immune response (GO:0002283)4.16520669
4response to peptidoglycan (GO:0032494)4.09004380
5T cell migration (GO:0072678)4.07138561
6positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.00062786
7neutrophil mediated immunity (GO:0002446)3.95652282
8positive regulation of gamma-delta T cell activation (GO:0046645)3.89758832
9positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.85952370
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.83890492
11positive regulation by organism of defense response of other organism involved in symbiotic interact3.83890492
12modulation by symbiont of host immune response (GO:0052553)3.83890492
13positive regulation by symbiont of host defense response (GO:0052509)3.83890492
14modulation by symbiont of host defense response (GO:0052031)3.83890492
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.83890492
16regulation of activation of Janus kinase activity (GO:0010533)3.83783002
17positive regulation of heat generation (GO:0031652)3.82151575
18protein localization to endosome (GO:0036010)3.81106312
19respiratory burst (GO:0045730)3.65885983
20regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.61298565
21positive regulation of alpha-beta T cell proliferation (GO:0046641)3.55922930
22response to muramyl dipeptide (GO:0032495)3.49508789
23leukocyte aggregation (GO:0070486)3.47304924
24positive regulation of interferon-alpha production (GO:0032727)3.44637589
25myeloid dendritic cell activation (GO:0001773)3.39258880
26myeloid dendritic cell differentiation (GO:0043011)3.39025540
27granulocyte activation (GO:0036230)3.35628270
28regulation of fever generation (GO:0031620)3.35147624
29cellular response to zinc ion (GO:0071294)3.34446442
30regulation of alpha-beta T cell proliferation (GO:0046640)3.33616123
31regulation of interleukin-12 biosynthetic process (GO:0045075)3.33526796
32positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.31537745
33heterotypic cell-cell adhesion (GO:0034113)3.30246222
34lipopolysaccharide-mediated signaling pathway (GO:0031663)3.30157513
35regulation of interferon-alpha production (GO:0032647)3.29464395
36monocyte chemotaxis (GO:0002548)3.29129341
37neutrophil activation (GO:0042119)3.25793623
38interferon-gamma production (GO:0032609)3.18290588
39positive regulation of interleukin-12 production (GO:0032735)3.17546226
40negative regulation of interleukin-12 production (GO:0032695)3.17540104
41germinal center formation (GO:0002467)3.13687542
42defense response to protozoan (GO:0042832)3.13287114
43negative regulation of interleukin-17 production (GO:0032700)3.11526919
44embryonic process involved in female pregnancy (GO:0060136)3.10672973
45cellular response to interferon-beta (GO:0035458)3.09867114
46myeloid leukocyte mediated immunity (GO:0002444)3.08094286
47leukocyte cell-cell adhesion (GO:0007159)3.04456912
48production of molecular mediator involved in inflammatory response (GO:0002532)3.03495452
49nuclear pore complex assembly (GO:0051292)3.02692597
50negative regulation of cell killing (GO:0031342)3.02533055
51negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.02533055
52iron ion import (GO:0097286)3.02481627
53positive regulation of leukocyte degranulation (GO:0043302)3.02437906
54negative regulation of erythrocyte differentiation (GO:0045647)3.00992458
55cellular response to thyroid hormone stimulus (GO:0097067)2.98357649
56positive regulation of interferon-beta production (GO:0032728)2.94491125
57positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.92762630
58response to protozoan (GO:0001562)2.92325532
59positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.92316537
60detection of external biotic stimulus (GO:0098581)2.91712610
61response to host immune response (GO:0052572)2.90936063
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.90936063
63regulation of chronic inflammatory response (GO:0002676)2.89972625
64wound healing, spreading of epidermal cells (GO:0035313)2.89429447
65negative regulation of protein localization to plasma membrane (GO:1903077)2.88666834
66regulation of T-helper 1 cell differentiation (GO:0045625)2.88159558
67cellular extravasation (GO:0045123)2.86983521
68NIK/NF-kappaB signaling (GO:0038061)2.85567516
69immunoglobulin mediated immune response (GO:0016064)2.85064615
70oligosaccharide catabolic process (GO:0009313)2.84927096
71positive regulation of interleukin-10 production (GO:0032733)2.84453255
72positive regulation of chemokine biosynthetic process (GO:0045080)2.84387488
73regulation of T-helper 2 cell differentiation (GO:0045628)2.84350429
74positive regulation of interleukin-2 production (GO:0032743)2.84196632
75response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.83994630
76response to host (GO:0075136)2.83994630
77response to host defenses (GO:0052200)2.83994630
78regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.83689962
79regulation of fibroblast apoptotic process (GO:2000269)2.82780689
80regulation of heat generation (GO:0031650)2.82474720
81regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.82354364
82regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.81093620
83myeloid cell activation involved in immune response (GO:0002275)2.79918565
84leukocyte mediated cytotoxicity (GO:0001909)2.79583630
85regulation of early endosome to late endosome transport (GO:2000641)2.78999321
86regulation of macrophage cytokine production (GO:0010935)2.75435158
87negative T cell selection (GO:0043383)2.75402365
88regulation of vitamin D biosynthetic process (GO:0060556)2.75045311
89positive regulation of antigen processing and presentation (GO:0002579)2.74853426
90positive regulation of T-helper 1 type immune response (GO:0002827)2.74459332
91regulation of interferon-beta biosynthetic process (GO:0045357)2.73827729
92lymphocyte chemotaxis (GO:0048247)2.72831850
93negative regulation by host of viral transcription (GO:0043922)2.72308764
94positive regulation of macrophage cytokine production (GO:0060907)2.70900059
95macrophage activation involved in immune response (GO:0002281)2.70543019
96positive regulation of Cdc42 GTPase activity (GO:0043089)2.70443126
97membrane raft organization (GO:0031579)2.69657734
98macrophage activation (GO:0042116)2.69568897
99positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.69328086
100positive regulation of T-helper cell differentiation (GO:0045624)2.68975606
101positive regulation of cellular amide metabolic process (GO:0034250)2.68936286
102positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.68071593
103positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.68048321
104lymphocyte migration (GO:0072676)2.68028270
105regulation of dendritic cell antigen processing and presentation (GO:0002604)2.67995863
106positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.67786378
107stress fiber assembly (GO:0043149)2.67468942
108regulation of chemokine biosynthetic process (GO:0045073)2.67009208
109positive regulation of keratinocyte differentiation (GO:0045618)2.66884900
110natural killer cell mediated immunity (GO:0002228)2.65256122
111natural killer cell mediated cytotoxicity (GO:0042267)2.65256122
112Rap protein signal transduction (GO:0032486)2.64237021
113detection of other organism (GO:0098543)2.62367681
114low-density lipoprotein particle clearance (GO:0034383)2.61717927
115positive regulation of isotype switching (GO:0045830)2.61499811
116T-helper cell differentiation (GO:0042093)2.61441082
117CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.61441082
118negative thymic T cell selection (GO:0045060)2.59016020
119positive regulation of chemokine production (GO:0032722)2.58352058
120regulation of interleukin-17 production (GO:0032660)2.58347765
121regulation of NF-kappaB import into nucleus (GO:0042345)2.58063747
122T-helper 1 type immune response (GO:0042088)2.57875067
123hepatocyte apoptotic process (GO:0097284)2.57473291
124positive regulation of NF-kappaB import into nucleus (GO:0042346)2.57377799
125regulation of interleukin-2 biosynthetic process (GO:0045076)2.57222096
126myeloid leukocyte activation (GO:0002274)2.56599297
127positive regulation of leukocyte apoptotic process (GO:2000108)2.56461597
128positive regulation of interleukin-1 beta production (GO:0032731)2.56389537
129pinocytosis (GO:0006907)2.56290126
130cytokine secretion (GO:0050663)2.55960246
131glycosphingolipid catabolic process (GO:0046479)2.55455586
132mammary gland epithelial cell proliferation (GO:0033598)2.55145235
133regulation of interleukin-12 production (GO:0032655)2.54532824
134T cell activation involved in immune response (GO:0002286)2.54288199
135regulation of memory T cell differentiation (GO:0043380)2.54053793
136regulation of leukocyte degranulation (GO:0043300)2.53943951
137JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.52039137
138hypotonic response (GO:0006971)2.49851422
139mRNA transcription (GO:0009299)2.47246739
140response to thyroid hormone (GO:0097066)2.46234797
141establishment of endothelial barrier (GO:0061028)2.45207895
142response to laminar fluid shear stress (GO:0034616)2.43250666
143regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.42954830
144cell adhesion mediated by integrin (GO:0033627)2.42691163
145detection of biotic stimulus (GO:0009595)2.41993400
146regulation of podosome assembly (GO:0071801)2.36027183
147nuclear pore organization (GO:0006999)2.35576822
148negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.34535404
149microglial cell activation (GO:0001774)2.33210466
150positive regulation of cellular response to insulin stimulus (GO:1900078)2.32520126
151negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.30468112
152positive regulation of receptor recycling (GO:0001921)2.29661730
153pore complex assembly (GO:0046931)2.28308505
154regulation of necroptotic process (GO:0060544)2.26788321
155regulation of glucose import in response to insulin stimulus (GO:2001273)2.26655623
156positive regulation of regulated secretory pathway (GO:1903307)2.26428276
157glycolipid catabolic process (GO:0019377)2.25979009
158positive regulation of endothelial cell apoptotic process (GO:2000353)2.25318928
159modulation by symbiont of host cellular process (GO:0044068)2.23879153
160regulation of membrane protein ectodomain proteolysis (GO:0051043)2.23824859
161peptide catabolic process (GO:0043171)2.23261182
162Golgi transport vesicle coating (GO:0048200)2.22199071
163COPI coating of Golgi vesicle (GO:0048205)2.22199071
164cellular response to arsenic-containing substance (GO:0071243)2.21667741
165regulation of gamma-delta T cell activation (GO:0046643)2.19667762
166cellular protein complex localization (GO:0034629)2.17960243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.17040171
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.48139267
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.31834754
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.29275711
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.86533491
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.87828228
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.79026745
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.49967781
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.48315860
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.47274411
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.25908375
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.19401336
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.97455371
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.85755300
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.84767891
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.82610089
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81658509
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.70845467
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.62324889
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.50262765
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40392187
22* SPI1_23547873_ChIP-Seq_NB4_Human2.22908467
23CLOCK_20551151_ChIP-Seq_293T_Human2.22897407
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.17222594
25RUNX_20019798_ChIP-Seq_JUKART_Human2.17193267
26MYB_26560356_Chip-Seq_TH2_Human2.02329649
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.96040127
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95898936
29SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.93415555
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.91091989
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.89322186
32* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.88812349
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82492460
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81112800
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74760089
36TCF7_22412390_ChIP-Seq_EML_Mouse1.69015414
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.63833567
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.61512326
39TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58876597
40PU_27001747_Chip-Seq_BMDM_Mouse1.58612264
41* VDR_24787735_ChIP-Seq_THP-1_Human1.58583790
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57629811
43KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.57247468
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57030349
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56160812
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.54680692
47VDR_24763502_ChIP-Seq_THP-1_Human1.54139981
48MYB_26560356_Chip-Seq_TH1_Human1.47948912
49* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47238247
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.46124217
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45748880
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44567720
53SCL_19346495_ChIP-Seq_HPC-7_Human1.42497208
54FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.41494341
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41396487
56ELK1_19687146_ChIP-ChIP_HELA_Human1.41298969
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40023695
58PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38793733
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38602623
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37116589
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36318118
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.36215249
63* ATF3_27146783_Chip-Seq_COLON_Human1.36095044
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36016518
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.34471833
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33736670
67GATA3_27048872_Chip-Seq_THYMUS_Human1.32794897
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32647164
69MAF_26560356_Chip-Seq_TH1_Human1.32339134
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32254947
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26757658
72SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25282186
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23794151
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22740252
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22435737
76RACK7_27058665_Chip-Seq_MCF-7_Human1.20817932
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.20638700
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20354602
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18482802
80* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17433543
81ZNF263_19887448_ChIP-Seq_K562_Human1.14232888
82FOXM1_23109430_ChIP-Seq_U2OS_Human1.12864636
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12575700
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10672695
85KDM2B_26808549_Chip-Seq_DND41_Human1.10066895
86AR_21909140_ChIP-Seq_LNCAP_Human1.10043288
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.09948570
88TRIM28_21343339_ChIP-Seq_HEK293_Human1.09498943
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07988849
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07086477
91GATA3_26560356_Chip-Seq_TH2_Human1.06712018
92UBF1/2_26484160_Chip-Seq_HMECs_Human1.05821513
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05757693
94* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05655824
95SPI1_23127762_ChIP-Seq_K562_Human1.05562838
96GATA1_22025678_ChIP-Seq_K562_Human1.04987345
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03467046
98RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03376849
99EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.02233101
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02145739
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00924812
102* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00310893
103STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99376287
104RUNX1_27514584_Chip-Seq_MCF-7_Human0.98092961
105* TFEB_21752829_ChIP-Seq_HELA_Human0.97702016
106* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97678178
107FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97420432
108CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97340702
109HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96470638
110LXR_22158963_ChIP-Seq_LIVER_Mouse0.96168447
111SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95658313
112TBX20_22080862_ChIP-Seq_HEART_Mouse0.94770716
113TBX20_22328084_ChIP-Seq_HEART_Mouse0.94770716
114* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94460231
115TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93904414
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92897742
117CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92859696
118CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92268345
119* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92120335
120VDR_21846776_ChIP-Seq_THP-1_Human0.89191527
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88406159
122* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84497714
123* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84497714
124* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84161814
125VDR_23849224_ChIP-Seq_CD4+_Human0.83583656
126SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81364256
127GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81130825
128HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79226241
129BRD4_25478319_ChIP-Seq_HGPS_Human0.77395143
130PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76679756
131FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.73927699
132FLI1_27457419_Chip-Seq_LIVER_Mouse0.73646357
133* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.72858201
134* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71133005
135CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.70739166
136UTX_26944678_Chip-Seq_JUKART_Human0.70480472
137PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69591782
138LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.68385656
139GATA2_21666600_ChIP-Seq_HMVEC_Human0.68382570
140MYC_22102868_ChIP-Seq_BL_Human0.65480465
141ERG_20887958_ChIP-Seq_HPC-7_Mouse0.65087036
142LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.63471784
143SMRT_27268052_Chip-Seq_Bcells_Human0.63169891
144TP53_16413492_ChIP-PET_HCT116_Human0.62814019
145* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.62400020
146TP63_19390658_ChIP-ChIP_HaCaT_Human0.61082852
147EWS_26573619_Chip-Seq_HEK293_Human0.59787333
148CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.59139802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.56288945
2MP0009785_altered_susceptibility_to3.43457501
3MP0005000_abnormal_immune_tolerance3.13764582
4MP0002148_abnormal_hypersensitivity_rea3.10621721
5MP0005451_abnormal_body_composition3.01868989
6MP0002419_abnormal_innate_immunity2.95300427
7MP0003436_decreased_susceptibility_to2.94528871
8MP0005671_abnormal_response_to2.90610908
9MP0003191_abnormal_cellular_cholesterol2.87761184
10MP0002452_abnormal_antigen_presenting2.58807259
11MP0003448_altered_tumor_morphology2.50754812
12MP0005025_abnormal_response_to2.49758833
13MP0002006_tumorigenesis2.45043618
14MP0002723_abnormal_immune_serum2.41356931
15MP0000685_abnormal_immune_system2.40114693
16MP0005387_immune_system_phenotype2.35602568
17MP0001790_abnormal_immune_system2.35602568
18MP0001800_abnormal_humoral_immune2.34549568
19MP0001819_abnormal_immune_cell2.32081964
20MP0002420_abnormal_adaptive_immunity2.31585127
21MP0004185_abnormal_adipocyte_glucose2.15774514
22MP0003303_peritoneal_inflammation2.14396585
23MP0006082_CNS_inflammation2.10744756
24MP0002009_preneoplasia2.04913152
25MP0010352_gastrointestinal_tract_polyps2.04433092
26MP0003705_abnormal_hypodermis_morpholog1.99918495
27MP0001853_heart_inflammation1.99185313
28MP0002405_respiratory_system_inflammati1.96933550
29MP0008057_abnormal_DNA_replication1.95970307
30MP0004510_myositis1.95321925
31MP0010234_abnormal_vibrissa_follicle1.90280394
32MP0000858_altered_metastatic_potential1.90220739
33MP0000569_abnormal_digit_pigmentation1.87296977
34MP0003763_abnormal_thymus_physiology1.86282684
35MP0002166_altered_tumor_susceptibility1.85127673
36MP0008260_abnormal_autophagy1.84453038
37MP0005666_abnormal_adipose_tissue1.83732640
38MP0003724_increased_susceptibility_to1.82788732
39MP0004947_skin_inflammation1.81069467
40MP0009333_abnormal_splenocyte_physiolog1.77637839
41MP0002398_abnormal_bone_marrow1.75550812
42MP0009840_abnormal_foam_cell1.74835809
43MP0002933_joint_inflammation1.73356981
44MP0005464_abnormal_platelet_physiology1.69191096
45MP0000716_abnormal_immune_system1.67590272
46MP0001533_abnormal_skeleton_physiology1.66459816
47MP0001845_abnormal_inflammatory_respons1.53244687
48MP0004233_abnormal_muscle_weight1.53010698
49MP0003828_pulmonary_edema1.46772138
50MP0003656_abnormal_erythrocyte_physiolo1.45729712
51MP0003221_abnormal_cardiomyocyte_apopto1.41492693
52MP0009764_decreased_sensitivity_to1.40502118
53MP0006054_spinal_hemorrhage1.37955622
54MP0003172_abnormal_lysosome_physiology1.37857769
55MP0002998_abnormal_bone_remodeling1.35163397
56MP0002722_abnormal_immune_system1.33807688
57MP0005076_abnormal_cell_differentiation1.33743010
58MP0005375_adipose_tissue_phenotype1.33249594
59MP0010155_abnormal_intestine_physiology1.32077483
60MP0002429_abnormal_blood_cell1.31872316
61MP0005397_hematopoietic_system_phenotyp1.31460995
62MP0001545_abnormal_hematopoietic_system1.31460995
63MP0001873_stomach_inflammation1.30844037
64MP0003075_altered_response_to1.30366526
65MP0000689_abnormal_spleen_morphology1.30160773
66MP0005623_abnormal_meninges_morphology1.29695722
67MP0003453_abnormal_keratinocyte_physiol1.29047158
68MP0002254_reproductive_system_inflammat1.26072324
69MP0000465_gastrointestinal_hemorrhage1.24494415
70MP0009278_abnormal_bone_marrow1.24048176
71MP0000604_amyloidosis1.23365104
72MP0002332_abnormal_exercise_endurance1.21782869
73MP0003693_abnormal_embryo_hatching1.16102836
74MP0002796_impaired_skin_barrier1.14911525
75MP0002971_abnormal_brown_adipose1.11810435
76MP0001727_abnormal_embryo_implantation1.11050213
77MP0009115_abnormal_fat_cell1.10198657
78MP0010678_abnormal_skin_adnexa1.09622637
79MP0001851_eye_inflammation1.09546541
80MP0005164_abnormal_response_to1.07647565
81MP0005174_abnormal_tail_pigmentation1.06698682
82MP0000703_abnormal_thymus_morphology1.04901064
83MP0003091_abnormal_cell_migration1.04521332
84MP0010307_abnormal_tumor_latency1.02711333
85MP0005166_decreased_susceptibility_to1.02655683
86MP0003566_abnormal_cell_adhesion1.01428651
87MP0003690_abnormal_glial_cell1.00761757
88MP0003941_abnormal_skin_development1.00473629
89MP0003183_abnormal_peptide_metabolism0.98641234
90MP0005058_abnormal_lysosome_morphology0.98120028
91MP0002877_abnormal_melanocyte_morpholog0.97684201
92MP0000490_abnormal_crypts_of0.95537078
93MP0008469_abnormal_protein_level0.94901437
94MP0000920_abnormal_myelination0.93886320
95MP0003329_amyloid_beta_deposits0.92808010
96MP0005390_skeleton_phenotype0.91818219
97MP0004808_abnormal_hematopoietic_stem0.91232652
98MP0004264_abnormal_extraembryonic_tissu0.88995354
99MP0005023_abnormal_wound_healing0.87139774
100MP0002277_abnormal_respiratory_mucosa0.86316039
101MP0000343_altered_response_to0.85839205
102MP0008874_decreased_physiological_sensi0.83810769
103MP0004130_abnormal_muscle_cell0.83664123
104MP0005167_abnormal_blood-brain_barrier0.83101419
105MP0003300_gastrointestinal_ulcer0.83042460
106MP0005248_abnormal_Harderian_gland0.82773808
107MP0010094_abnormal_chromosome_stability0.82287605
108MP0000627_abnormal_mammary_gland0.82192610
109MP0005310_abnormal_salivary_gland0.81908092
110MP0002396_abnormal_hematopoietic_system0.79726851
111MP0004782_abnormal_surfactant_physiolog0.76960299
112MP0005165_increased_susceptibility_to0.76840310
113MP0001881_abnormal_mammary_gland0.76030211
114MP0003077_abnormal_cell_cycle0.75859652
115MP0003795_abnormal_bone_structure0.75853185
116MP0008004_abnormal_stomach_pH0.75733504
117MP0003045_fibrosis0.75637699
118MP0003806_abnormal_nucleotide_metabolis0.74693374
119MP0000383_abnormal_hair_follicle0.74501961
120MP0001216_abnormal_epidermal_layer0.74344264
121MP0002019_abnormal_tumor_incidence0.72197211
122MP0004883_abnormal_blood_vessel0.71106036
123MP0008007_abnormal_cellular_replicative0.70002067
124MP0008058_abnormal_DNA_repair0.68851295
125MP0001191_abnormal_skin_condition0.68786322
126MP0000371_diluted_coat_color0.67621138
127MP0005621_abnormal_cell_physiology0.66079582
128MP0003111_abnormal_nucleus_morphology0.62319857
129MP0009384_cardiac_valve_regurgitation0.60732038
130MP0000350_abnormal_cell_proliferation0.60020024
131MP0000249_abnormal_blood_vessel0.59596527
132MP0009763_increased_sensitivity_to0.58436767
133MP0000733_abnormal_muscle_development0.56658928
134MP0003950_abnormal_plasma_membrane0.54023297
135MP0005171_absent_coat_pigmentation0.52609717

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)6.37313595
2Retrobulbar optic neuritis (HP:0100654)6.37313595
3Myositis (HP:0100614)6.18068097
4Recurrent abscess formation (HP:0002722)5.85827180
5Orchitis (HP:0100796)5.65738020
6Recurrent bacterial skin infections (HP:0005406)5.19964810
7Stomatitis (HP:0010280)4.49207163
8Eczematoid dermatitis (HP:0000976)4.43456026
9Mediastinal lymphadenopathy (HP:0100721)4.36609099
10Keratoconjunctivitis sicca (HP:0001097)4.20862843
11Abnormality of liposaccharide metabolism (HP:0010968)4.05826113
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.05826113
13Abnormality of glycolipid metabolism (HP:0010969)4.05826113
14Elevated erythrocyte sedimentation rate (HP:0003565)3.99317933
15Keratoconjunctivitis (HP:0001096)3.72268195
16Obstructive lung disease (HP:0006536)3.17728594
17Chronic obstructive pulmonary disease (HP:0006510)3.17728594
18Abnormality of macrophages (HP:0004311)3.16546267
19Epiphyseal dysplasia (HP:0002656)3.06619123
20Recurrent gram-negative bacterial infections (HP:0005420)3.01663634
21Pulmonary infiltrates (HP:0002113)2.96866728
22Vasculitis (HP:0002633)2.92408519
23Small epiphyses (HP:0010585)2.90036724
24Myocardial infarction (HP:0001658)2.82269813
25Hematochezia (HP:0002573)2.80315690
26Irregular epiphyses (HP:0010582)2.77797363
27Gingivitis (HP:0000230)2.74696371
28Basal ganglia calcification (HP:0002135)2.71666085
29Recurrent skin infections (HP:0001581)2.69589006
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.68351521
31Hemoptysis (HP:0002105)2.66959062
32Subacute progressive viral hepatitis (HP:0006572)2.66043820
33Poor head control (HP:0002421)2.65929375
34T lymphocytopenia (HP:0005403)2.65831734
35Vertebral compression fractures (HP:0002953)2.64174663
36Aseptic necrosis (HP:0010885)2.62556854
37Birth length less than 3rd percentile (HP:0003561)2.61983226
38Cerebral inclusion bodies (HP:0100314)2.61319568
39Arterial thrombosis (HP:0004420)2.60385308
40Chronic otitis media (HP:0000389)2.58391145
41Termporal pattern (HP:0011008)2.58057309
42Insidious onset (HP:0003587)2.58057309
43Encephalitis (HP:0002383)2.54041634
44Osteolytic defects of the hand bones (HP:0009699)2.53794975
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.53794975
46Abnormality of T cell number (HP:0011839)2.53388280
47Recurrent pneumonia (HP:0006532)2.51986579
48Thick nail (HP:0001805)2.51952307
49Abnormality of the pericardium (HP:0001697)2.51920626
50Recurrent viral infections (HP:0004429)2.51008088
51Tetraparesis (HP:0002273)2.50642662
52Neurofibrillary tangles (HP:0002185)2.49891385
53Recurrent fungal infections (HP:0002841)2.49109125
54Progressive external ophthalmoplegia (HP:0000590)2.48227297
55Resting tremor (HP:0002322)2.47840996
56Asymmetric septal hypertrophy (HP:0001670)2.47181585
57Agnosia (HP:0010524)2.46783004
58Loss of speech (HP:0002371)2.45681557
59Asymmetry of the thorax (HP:0001555)2.42832034
60Pustule (HP:0200039)2.41763563
61Gangrene (HP:0100758)2.40402772
62Petechiae (HP:0000967)2.39563101
63Prostate neoplasm (HP:0100787)2.38209707
64Anorexia (HP:0002039)2.37137103
65Leukocytosis (HP:0001974)2.32625969
66Micronodular cirrhosis (HP:0001413)2.32224602
67Meningitis (HP:0001287)2.31973411
68Dysostosis multiplex (HP:0000943)2.30878380
69Slow saccadic eye movements (HP:0000514)2.22993100
70Abnormality of the pleura (HP:0002103)2.21844108
71Papillary thyroid carcinoma (HP:0002895)2.20993149
72Anhidrosis (HP:0000970)2.17287684
73Curly hair (HP:0002212)2.16526627
74Absent frontal sinuses (HP:0002688)2.16428278
75Fatigue (HP:0012378)2.15751318
76Keratitis (HP:0000491)2.15674303
77Amyloidosis (HP:0011034)2.12743447
78Distal lower limb muscle weakness (HP:0009053)2.11304341
79Ankyloglossia (HP:0010296)2.08872960
80Colitis (HP:0002583)2.07357475
81Increased IgM level (HP:0003496)2.06908926
82Esophageal varix (HP:0002040)2.03697404
83Hyporeflexia of lower limbs (HP:0002600)2.03697229
84Eosinophilia (HP:0001880)1.99052451
85Spondylolisthesis (HP:0003302)1.98838816
86Periodontitis (HP:0000704)1.98100741
87Disinhibition (HP:0000734)1.97062388
88Increased CSF protein (HP:0002922)1.96654089
89Bone pain (HP:0002653)1.95994935
90Abnormality of the vertebral endplates (HP:0005106)1.95373211
91Apathy (HP:0000741)1.94658230
92Recurrent lower respiratory tract infections (HP:0002783)1.94493546
93Diminished motivation (HP:0000745)1.92771903
94Increased neuronal autofluorescent lipopigment (HP:0002074)1.90849305
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90634768
96Glomerulopathy (HP:0100820)1.89400197
97Mucopolysacchariduria (HP:0008155)1.88907861
98Urinary glycosaminoglycan excretion (HP:0003541)1.88907861
99Increased cerebral lipofuscin (HP:0011813)1.88742374
100Abnormality of eosinophils (HP:0001879)1.87779102
101Cellulitis (HP:0100658)1.87563384
102Deep philtrum (HP:0002002)1.86042083
103Progressive neurologic deterioration (HP:0002344)1.85794499
104Viral hepatitis (HP:0006562)1.85200602
105Abnormality of oral frenula (HP:0000190)1.85070201
106Spontaneous hematomas (HP:0007420)1.84411503
107Inflammation of the large intestine (HP:0002037)1.83554331
108Abnormality of the columella (HP:0009929)1.81226233
109Abnormality of skeletal muscle fiber size (HP:0012084)1.80932775
110Neuronal loss in central nervous system (HP:0002529)1.80314202
111Thyroiditis (HP:0100646)1.79963299
112Axonal loss (HP:0003447)1.79922540
113Thrombocytosis (HP:0001894)1.79725706
114Subaortic stenosis (HP:0001682)1.78779674
115Abnormality of the left ventricular outflow tract (HP:0011103)1.78779674
116Abnormality of the vasculature of the conjunctiva (HP:0008054)1.78162884
117Interstitial pulmonary disease (HP:0006530)1.77987360
118Arthralgia (HP:0002829)1.77638959
119Stomach cancer (HP:0012126)1.77432187
120Abnormality of the common coagulation pathway (HP:0010990)1.76357178
121Vacuolated lymphocytes (HP:0001922)1.76305972
122Polycythemia (HP:0001901)1.73840554
123Personality changes (HP:0000751)1.73218819
124Nuclear cataract (HP:0100018)1.72973953
125Parakeratosis (HP:0001036)1.72892030
126Gastrointestinal inflammation (HP:0004386)1.72885535
127Increased connective tissue (HP:0009025)1.72796754
128Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71510784
129Abnormality of polysaccharide metabolism (HP:0011012)1.71510784
130Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71510784
131Hyperparathyroidism (HP:0000843)1.71424149
132Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.69707315
133Segmental peripheral demyelination/remyelination (HP:0003481)1.69648667
134Barrel-shaped chest (HP:0001552)1.68631648
135Increased variability in muscle fiber diameter (HP:0003557)1.68164158
136Flattened epiphyses (HP:0003071)1.67955566
137Hypergammaglobulinemia (HP:0010702)1.67719604
138Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.65948548
139Hepatosplenomegaly (HP:0001433)1.65440258
140Pathologic fracture (HP:0002756)1.65320133
141Flat capital femoral epiphysis (HP:0003370)1.64733458
142Increased serum ferritin (HP:0003281)1.64563880
143Short nail (HP:0001799)1.63249954
144J-shaped sella turcica (HP:0002680)1.62897126
145Distal lower limb amyotrophy (HP:0008944)1.62556749
146Difficulty running (HP:0009046)1.61561290
147Autoimmune hemolytic anemia (HP:0001890)1.60649436
148Menstrual irregularities (HP:0000858)1.60572486
149Amaurosis fugax (HP:0100576)1.60271255
150Vitreoretinal degeneration (HP:0000655)1.60224408
151Stenosis of the external auditory canal (HP:0000402)1.57802900
152Syringomyelia (HP:0003396)1.57704519
153Spinal cord lesions (HP:0100561)1.57704519
154Polyneuropathy (HP:0001271)1.57625328
155Premature loss of primary teeth (HP:0006323)1.56916377
156Metaphyseal cupping (HP:0003021)1.54266624
157Dry hair (HP:0011359)1.53973077
158Osteomyelitis (HP:0002754)1.53838733
159Lymphoma (HP:0002665)1.53559186
160Severe combined immunodeficiency (HP:0004430)1.52896790
161Granulocytopenia (HP:0001913)1.51972487
162Flared metaphyses (HP:0003015)1.51797887
16311 pairs of ribs (HP:0000878)1.51765809
164Genu varum (HP:0002970)1.50402954
165Vertigo (HP:0002321)1.49480668
166Abnormality of the prostate (HP:0008775)1.49099414
167Arterial tortuosity (HP:0005116)1.48963800
168Hypoplastic pelvis (HP:0008839)1.47294681
169Mild short stature (HP:0003502)1.47100226
170Gastrointestinal infarctions (HP:0005244)1.46670078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.70830857
2PBK3.36816399
3IRAK32.99262158
4TXK2.97981818
5RIPK42.96291522
6BLK2.78704528
7TBK12.53723662
8TRIB32.53281717
9CLK12.28041660
10MAP3K132.26764856
11IKBKB2.21995688
12JAK32.19080782
13MST42.18492379
14PIM22.09000695
15MAP2K32.08301981
16NME22.03086690
17ACVR1B1.93340849
18MELK1.91385512
19IRAK41.86700118
20MAP4K11.77849081
21CDK81.73660191
22TYK21.64521107
23ERN11.58907188
24PRPF4B1.52422314
25SIK31.52166965
26PIM11.49535955
27MAP3K31.49380830
28ITK1.47014083
29MARK31.46725332
30CHUK1.44286795
31IKBKE1.43518007
32TTN1.43130532
33LATS21.42055651
34PAK41.40260003
35MST1R1.36048438
36IRAK21.34476353
37PDGFRA1.28087577
38MAP3K11.27944587
39MATK1.26705556
40JAK11.25667399
41MAP3K121.25619342
42EIF2AK21.24605094
43STK241.23559212
44LCK1.23114142
45WEE11.22510328
46BMX1.21683765
47RPS6KA41.20813299
48TAOK21.19987559
49HCK1.18228902
50MAP2K61.17045080
51NEK91.16559099
52EPHB11.15964030
53RAF11.15234715
54PLK21.13713958
55ERBB31.13385024
56TRPM71.12377458
57SYK1.11831574
58NUAK11.08207534
59STK101.06260763
60YES11.06008040
61STK41.05625369
62BRSK21.05185231
63NLK1.04631056
64KIT1.04480476
65MAP3K61.04062064
66FGFR41.02552724
67EPHA31.01294176
68LYN1.00592103
69PDPK10.96554560
70TESK10.96120166
71CDK90.95312639
72EIF2AK10.93120805
73BRD40.92345924
74SMG10.91767928
75CSK0.91311336
76CDK40.89859877
77NEK60.86868405
78FGFR30.86859928
79ZAP700.86303561
80MAP3K90.86242434
81BTK0.85466329
82PRKG20.85386802
83RIPK10.84520054
84BMPR20.83295401
85RPS6KB20.83124003
86CSF1R0.82325949
87PKN20.80929768
88CDK60.80815473
89MOS0.79855569
90FGR0.79101889
91STK30.78846369
92SIK20.76135271
93ARAF0.75273401
94ICK0.74358736
95RET0.74308482
96TEC0.73633024
97PDK10.65634471
98EPHA20.65008925
99IRAK10.63631971
100ABL10.62191611
101ALK0.61872105
102PIK3CG0.61380728
103PRKCQ0.60884519
104DMPK0.60537381
105FES0.60007208
106PRKCD0.59611621
107KSR10.57929918
108MAP3K80.57556545
109PTK20.56879026
110MTOR0.55311352
111SGK30.54548872
112EIF2AK30.53502673
113LRRK20.52948356
114TAOK10.51584184
115ATR0.50204982
116GRK70.49716885
117SCYL20.49086541
118VRK10.49040892
119EEF2K0.48817024
120STK38L0.48737451
121CDK120.48590586
122PTK60.48527018
123CAMKK20.48344923
124DDR20.45314679
125CHEK20.44565776
126JAK20.42090603
127MAPKAPK20.41604992
128ROCK20.41160317
129PIK3CA0.40851446
130MAP3K20.40099165
131PDGFRB0.37182334
132ZAK0.36729044
133MAP3K50.35822400
134EGFR0.35215150
135PLK30.34007724
136MKNK10.33910422
137ADRBK20.33822164
138KSR20.32404379
139SGK10.30199801
140TNIK0.29590309
141MKNK20.28907064
142SIK10.27045839
143ERBB40.26477316
144RPS6KA50.26014907
145INSR0.23935830
146CDC70.23663733
147BRSK10.23376583
148PAK60.22961973
149TGFBR20.22485955
150MET0.22305656

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.19575566
2NOD-like receptor signaling pathway_Homo sapiens_hsa046212.48991948
3Leishmaniasis_Homo sapiens_hsa051402.47740359
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.44733111
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.41347936
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.39656142
7Allograft rejection_Homo sapiens_hsa053302.38226670
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.22104051
9Type I diabetes mellitus_Homo sapiens_hsa049402.19677365
10Legionellosis_Homo sapiens_hsa051342.13893941
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.95591287
12Rheumatoid arthritis_Homo sapiens_hsa053231.94384777
13Malaria_Homo sapiens_hsa051441.92161022
14Other glycan degradation_Homo sapiens_hsa005111.91338462
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.86100787
16Osteoclast differentiation_Homo sapiens_hsa043801.83638628
17Antigen processing and presentation_Homo sapiens_hsa046121.75452872
18Measles_Homo sapiens_hsa051621.71242557
19Pertussis_Homo sapiens_hsa051331.71198047
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.70413562
21Tuberculosis_Homo sapiens_hsa051521.59975420
22Hematopoietic cell lineage_Homo sapiens_hsa046401.59925252
23Non-small cell lung cancer_Homo sapiens_hsa052231.54818714
24TNF signaling pathway_Homo sapiens_hsa046681.50976270
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48922189
26Bladder cancer_Homo sapiens_hsa052191.44475807
27Autoimmune thyroid disease_Homo sapiens_hsa053201.41105831
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39153370
29Thyroid cancer_Homo sapiens_hsa052161.36025752
30B cell receptor signaling pathway_Homo sapiens_hsa046621.33974704
31Herpes simplex infection_Homo sapiens_hsa051681.30410735
32VEGF signaling pathway_Homo sapiens_hsa043701.28652724
33Salmonella infection_Homo sapiens_hsa051321.28159036
34Hepatitis B_Homo sapiens_hsa051611.27976518
35Prolactin signaling pathway_Homo sapiens_hsa049171.27061826
36T cell receptor signaling pathway_Homo sapiens_hsa046601.25421226
37Influenza A_Homo sapiens_hsa051641.22693780
38Phagosome_Homo sapiens_hsa041451.21516927
39Endometrial cancer_Homo sapiens_hsa052131.21357797
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21315302
41Viral myocarditis_Homo sapiens_hsa054161.17262833
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17103119
43Chemokine signaling pathway_Homo sapiens_hsa040621.16294750
44African trypanosomiasis_Homo sapiens_hsa051431.12718239
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.11542079
46Primary immunodeficiency_Homo sapiens_hsa053401.09594439
47Shigellosis_Homo sapiens_hsa051311.09278550
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08092467
49Apoptosis_Homo sapiens_hsa042101.07769100
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06045656
51ErbB signaling pathway_Homo sapiens_hsa040121.05884209
52Asthma_Homo sapiens_hsa053101.05718184
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.04614433
54Lysosome_Homo sapiens_hsa041421.00567953
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00475857
56Toxoplasmosis_Homo sapiens_hsa051450.98510026
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.97518540
58Glioma_Homo sapiens_hsa052140.96714861
59Pentose phosphate pathway_Homo sapiens_hsa000300.93519562
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.89493609
61Staphylococcus aureus infection_Homo sapiens_hsa051500.89379016
62p53 signaling pathway_Homo sapiens_hsa041150.88909981
63Dorso-ventral axis formation_Homo sapiens_hsa043200.88372996
64Insulin signaling pathway_Homo sapiens_hsa049100.86847669
65Inositol phosphate metabolism_Homo sapiens_hsa005620.84996279
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84492364
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81382766
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81151214
69Insulin resistance_Homo sapiens_hsa049310.77645473
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77083516
71Estrogen signaling pathway_Homo sapiens_hsa049150.76464500
72Chronic myeloid leukemia_Homo sapiens_hsa052200.74536775
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74099662
74Amoebiasis_Homo sapiens_hsa051460.73657398
75Endocytosis_Homo sapiens_hsa041440.73344063
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72534769
77Epstein-Barr virus infection_Homo sapiens_hsa051690.71724509
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71050000
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68159115
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67771430
81MicroRNAs in cancer_Homo sapiens_hsa052060.67584196
82Small cell lung cancer_Homo sapiens_hsa052220.67347676
83HTLV-I infection_Homo sapiens_hsa051660.67049569
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.65181452
85GnRH signaling pathway_Homo sapiens_hsa049120.65087889
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65043213
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.64672129
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.63738366
89Hepatitis C_Homo sapiens_hsa051600.63579031
90DNA replication_Homo sapiens_hsa030300.62899032
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62791650
92Pancreatic cancer_Homo sapiens_hsa052120.61936355
93Fatty acid biosynthesis_Homo sapiens_hsa000610.61856151
94Proteasome_Homo sapiens_hsa030500.58852119
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58587296
96Cell cycle_Homo sapiens_hsa041100.58149509
97Protein export_Homo sapiens_hsa030600.57869899
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.57550965
99AMPK signaling pathway_Homo sapiens_hsa041520.56272088
100Homologous recombination_Homo sapiens_hsa034400.56147361
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56063807
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55963399
103Acute myeloid leukemia_Homo sapiens_hsa052210.55881237
104Choline metabolism in cancer_Homo sapiens_hsa052310.53921153
105Mismatch repair_Homo sapiens_hsa034300.53082499
106Colorectal cancer_Homo sapiens_hsa052100.51203209
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49957717
108HIF-1 signaling pathway_Homo sapiens_hsa040660.49046664
109Proteoglycans in cancer_Homo sapiens_hsa052050.48824630
110Platelet activation_Homo sapiens_hsa046110.47318100
111Renal cell carcinoma_Homo sapiens_hsa052110.47235981
112Nucleotide excision repair_Homo sapiens_hsa034200.45575094
113Fanconi anemia pathway_Homo sapiens_hsa034600.44203837
114RNA polymerase_Homo sapiens_hsa030200.43573722
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42625223
116Viral carcinogenesis_Homo sapiens_hsa052030.42260790
117Focal adhesion_Homo sapiens_hsa045100.41138135
118ECM-receptor interaction_Homo sapiens_hsa045120.40754233
119Spliceosome_Homo sapiens_hsa030400.40493481
120mTOR signaling pathway_Homo sapiens_hsa041500.39785417
121FoxO signaling pathway_Homo sapiens_hsa040680.39246614
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38581543
123Prostate cancer_Homo sapiens_hsa052150.36812927
124Type II diabetes mellitus_Homo sapiens_hsa049300.36081668
125Adherens junction_Homo sapiens_hsa045200.34813751
126Prion diseases_Homo sapiens_hsa050200.34382031
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34198971
128RNA degradation_Homo sapiens_hsa030180.33793673
129MAPK signaling pathway_Homo sapiens_hsa040100.33707220
130Sphingolipid metabolism_Homo sapiens_hsa006000.32740841
131Non-homologous end-joining_Homo sapiens_hsa034500.31556346

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