OSM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)5.57286948
2modulation by symbiont of host defense response (GO:0052031)5.57286948
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.57286948
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.57286948
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.57286948
6modulation by symbiont of host immune response (GO:0052553)5.57286948
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.02597252
8response to peptidoglycan (GO:0032494)4.71459913
9neutrophil activation involved in immune response (GO:0002283)4.64873527
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.51337019
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.51337019
12leukocyte aggregation (GO:0070486)4.48768291
13detection of molecule of bacterial origin (GO:0032490)4.47289079
14germinal center formation (GO:0002467)4.37864214
15macrophage activation involved in immune response (GO:0002281)4.36399805
16positive regulation of mast cell activation involved in immune response (GO:0033008)4.35623771
17positive regulation of mast cell degranulation (GO:0043306)4.35623771
18regulation of B cell receptor signaling pathway (GO:0050855)4.34133812
19cellular extravasation (GO:0045123)4.29573176
20immunoglobulin mediated immune response (GO:0016064)4.24537238
21detection of other organism (GO:0098543)4.15040392
22antigen processing and presentation of endogenous antigen (GO:0019883)4.10096824
23positive regulation of mast cell activation (GO:0033005)4.09003303
24regulation of interferon-beta biosynthetic process (GO:0045357)4.02001607
25response to muramyl dipeptide (GO:0032495)4.01198708
26microglial cell activation (GO:0001774)3.96847554
27tolerance induction (GO:0002507)3.90036722
28positive regulation of gamma-delta T cell activation (GO:0046645)3.86406367
29regulation of mast cell degranulation (GO:0043304)3.85984561
30respiratory burst (GO:0045730)3.84393226
31regulation of gamma-delta T cell activation (GO:0046643)3.81494072
32T-helper 1 type immune response (GO:0042088)3.76779175
33production of molecular mediator involved in inflammatory response (GO:0002532)3.76459964
34negative regulation of interleukin-12 production (GO:0032695)3.75075853
35positive regulation of interferon-alpha production (GO:0032727)3.72121280
36positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.71952366
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.69060158
38detection of external biotic stimulus (GO:0098581)3.66605661
39neutrophil mediated immunity (GO:0002446)3.64319800
40response to host immune response (GO:0052572)3.61015868
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.61015868
42regulation of interferon-alpha production (GO:0032647)3.58372137
43regulation of interleukin-12 biosynthetic process (GO:0045075)3.58362695
44interferon-gamma production (GO:0032609)3.57871850
45positive regulation of heat generation (GO:0031652)3.56918578
46detection of bacterium (GO:0016045)3.55704353
47myeloid cell activation involved in immune response (GO:0002275)3.54618550
48neutrophil activation (GO:0042119)3.53748459
49regulation of mast cell activation involved in immune response (GO:0033006)3.53056436
50lipopolysaccharide-mediated signaling pathway (GO:0031663)3.52979718
51positive regulation of B cell differentiation (GO:0045579)3.52574537
52regulation of fever generation (GO:0031620)3.51042000
53detection of biotic stimulus (GO:0009595)3.48533699
54regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.47963840
55positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.46502411
56granulocyte activation (GO:0036230)3.42535038
57neutrophil chemotaxis (GO:0030593)3.42504540
58regulation of vitamin D biosynthetic process (GO:0060556)3.37451987
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.36757453
60response to host (GO:0075136)3.36757453
61response to host defenses (GO:0052200)3.36757453
62positive regulation of antigen processing and presentation (GO:0002579)3.36066539
63negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.34862302
64negative regulation of cell killing (GO:0031342)3.34862302
65positive regulation of leukocyte degranulation (GO:0043302)3.34091800
66neutrophil migration (GO:1990266)3.33659816
67negative regulation of erythrocyte differentiation (GO:0045647)3.33525331
68regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.30383936
69regulation of mast cell activation (GO:0033003)3.29327378
70regulation of hypersensitivity (GO:0002883)3.25769963
71regulation of T-helper 2 cell differentiation (GO:0045628)3.25662668
72positive regulation of macrophage differentiation (GO:0045651)3.25101973
73T cell migration (GO:0072678)3.25016619
74positive regulation of NF-kappaB import into nucleus (GO:0042346)3.24843816
75B cell mediated immunity (GO:0019724)3.23400096
76regulation of B cell differentiation (GO:0045577)3.23001402
77macrophage activation (GO:0042116)3.18768336
78regulation of myeloid leukocyte mediated immunity (GO:0002886)3.18697682
79positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.18484057
80regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.18209385
81Arp2/3 complex-mediated actin nucleation (GO:0034314)3.17286080
82JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.14513210
83positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.14314113
84negative regulation of cytokine production involved in immune response (GO:0002719)3.14250059
85regulation of leukocyte degranulation (GO:0043300)3.13852778
86positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.13423955
87negative regulation of granulocyte differentiation (GO:0030853)3.13412952
88G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.13038842
89interferon-gamma-mediated signaling pathway (GO:0060333)3.11017427
90mast cell activation (GO:0045576)3.10414046
91negative regulation of interleukin-6 production (GO:0032715)3.10342714
92negative regulation of lymphocyte mediated immunity (GO:0002707)3.02647055
93negative regulation of T cell mediated immunity (GO:0002710)3.02491096
94granulocyte chemotaxis (GO:0071621)2.99932517
95regulation of antigen processing and presentation (GO:0002577)2.99147109
96positive regulation of type 2 immune response (GO:0002830)2.98937189
97negative regulation of interleukin-1 beta production (GO:0032691)2.98514607
98cytokine secretion (GO:0050663)2.97672617
99myeloid leukocyte mediated immunity (GO:0002444)2.97394770
100positive regulation of interferon-beta production (GO:0032728)2.94061483
101type I interferon signaling pathway (GO:0060337)2.93050306
102cellular response to type I interferon (GO:0071357)2.93050306
103response to type I interferon (GO:0034340)2.91492986
104myeloid dendritic cell activation (GO:0001773)2.91454633
105regulation of gamma-delta T cell differentiation (GO:0045586)2.90295386
106positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.89727716
107myeloid dendritic cell differentiation (GO:0043011)2.89230372
108granulocyte migration (GO:0097530)2.88557713
109leukocyte cell-cell adhesion (GO:0007159)2.86216477
110response to protozoan (GO:0001562)2.85796920
111eosinophil migration (GO:0072677)2.85652001
112myeloid leukocyte activation (GO:0002274)2.84057112
113negative regulation of leukocyte mediated immunity (GO:0002704)2.82141927
114positive regulation of interleukin-10 production (GO:0032733)2.81775569
115positive regulation of chemokine biosynthetic process (GO:0045080)2.81450080
116B cell receptor signaling pathway (GO:0050853)2.80892018
117* positive regulation of acute inflammatory response (GO:0002675)2.80550982
118actin nucleation (GO:0045010)2.78982394
119regulation of dendritic cell antigen processing and presentation (GO:0002604)2.76835089
120negative regulation of interleukin-1 production (GO:0032692)2.74514011
121negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.73969969
122regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.73921814
123positive regulation of immunoglobulin mediated immune response (GO:0002891)2.73385228
124positive regulation of B cell mediated immunity (GO:0002714)2.73385228
125regulation of T-helper 1 cell differentiation (GO:0045625)2.73101433
126NIK/NF-kappaB signaling (GO:0038061)2.72805608
127regulation of NF-kappaB import into nucleus (GO:0042345)2.72737701
128positive regulation of cytokine biosynthetic process (GO:0042108)2.69754508
129negative regulation of phagocytosis (GO:0050765)2.68836551
130positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.67350861
131G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.67344209
132pinocytosis (GO:0006907)2.67151810
133regulation of interleukin-8 biosynthetic process (GO:0045414)2.66870905
134defense response to protozoan (GO:0042832)2.66305742
135response to laminar fluid shear stress (GO:0034616)2.65782113
136antigen processing and presentation via MHC class Ib (GO:0002475)2.64927850

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.91313945
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.88635383
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.87831802
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.75787886
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.72505306
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.57959657
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.57585377
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.56383864
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.36766982
10* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.25462545
11E2F7_22180533_ChIP-Seq_HELA_Human3.19765937
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.19550910
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.13527092
14* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.89026020
15SCL_19346495_ChIP-Seq_HPC-7_Human2.76236152
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73882312
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.71743059
18* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.65963196
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.56614641
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.55600703
21VDR_21846776_ChIP-Seq_THP-1_Human2.55367953
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.42505164
23RUNX_20019798_ChIP-Seq_JUKART_Human2.34923650
24* SPI1_23547873_ChIP-Seq_NB4_Human2.33014011
25* MYB_26560356_Chip-Seq_TH2_Human2.32337690
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.30249562
27MYC_22102868_ChIP-Seq_BL_Human2.28775871
28MAF_26560356_Chip-Seq_TH1_Human2.28120178
29* VDR_24763502_ChIP-Seq_THP-1_Human2.27933756
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.26814638
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.20518108
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.19531638
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.01947108
34* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01650616
35MYB_26560356_Chip-Seq_TH1_Human1.91584050
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.89347846
37TCF7_22412390_ChIP-Seq_EML_Mouse1.86719887
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85091641
39SPI1_23127762_ChIP-Seq_K562_Human1.83639888
40PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.83330249
41UTX_26944678_Chip-Seq_JUKART_Human1.80845086
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76840842
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.75874004
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61914683
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57261842
46* PU_27001747_Chip-Seq_BMDM_Mouse1.56956691
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56238842
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.55825962
49* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54619350
50* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46634626
51MAF_26560356_Chip-Seq_TH2_Human1.44311777
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41983021
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.40592509
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38081735
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36892744
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36717425
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35668433
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.33000450
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.28691593
60* KDM2B_26808549_Chip-Seq_DND41_Human1.27981792
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27308831
62* GATA3_27048872_Chip-Seq_THYMUS_Human1.26092502
63VDR_24787735_ChIP-Seq_THP-1_Human1.25560499
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23576347
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23137309
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20413661
67* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20003309
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19825980
69* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19064275
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15125043
71* GATA3_26560356_Chip-Seq_TH2_Human1.14012332
72* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13529368
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12106682
74* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11842081
75* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11022986
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07847348
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.06286350
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05967909
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05777432
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03338763
81KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03338763
82KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03338763
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02349235
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00406506
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95547902
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94369538
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91875849
88HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91829756
89GATA1_19941826_ChIP-Seq_K562_Human0.89146931
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85076470
91* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84872331
92LXR_22292898_ChIP-Seq_THP-1_Human0.83051517
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83004426
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81811205
95NCOR1_26117541_ChIP-Seq_K562_Human0.80178932
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80127512
97GATA2_19941826_ChIP-Seq_K562_Human0.79817083
98BCL6_27268052_Chip-Seq_Bcells_Human0.79657759
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.78843296
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.78376201
101BCOR_27268052_Chip-Seq_Bcells_Human0.78125549
102TFEB_21752829_ChIP-Seq_HELA_Human0.78076066
103SPI1_20517297_ChIP-Seq_HL60_Human0.77098967
104RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76362511
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75275703
106GATA1_22025678_ChIP-Seq_K562_Human0.72648184
107ERG_20887958_ChIP-Seq_HPC-7_Mouse0.72430795
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70368082
109KDM2B_26808549_Chip-Seq_JURKAT_Human0.69873559
110E2F4_17652178_ChIP-ChIP_JURKAT_Human0.69517904
111ELF1_17652178_ChIP-ChIP_JURKAT_Human0.68200245
112CTCF_27219007_Chip-Seq_ERYTHROID_Human0.68188669
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66784820
114GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66506600

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.06118943
2MP0003436_decreased_susceptibility_to3.93179843
3MP0003303_peritoneal_inflammation3.76668360
4MP0005671_abnormal_response_to3.12216231
5MP0009785_altered_susceptibility_to3.06162732
6MP0005000_abnormal_immune_tolerance3.04814208
7MP0002148_abnormal_hypersensitivity_rea3.04665601
8MP0004510_myositis3.02434621
9MP0002419_abnormal_innate_immunity2.96086631
10MP0006082_CNS_inflammation2.95369706
11MP0005025_abnormal_response_to2.79256346
12MP0001800_abnormal_humoral_immune2.76218051
13MP0002452_abnormal_antigen_presenting2.72208695
14MP0005387_immune_system_phenotype2.69462856
15MP0001790_abnormal_immune_system2.69462856
16MP0002723_abnormal_immune_serum2.60612951
17MP0008004_abnormal_stomach_pH2.58025157
18MP0003191_abnormal_cellular_cholesterol2.57739958
19MP0003724_increased_susceptibility_to2.53740266
20MP0000685_abnormal_immune_system2.51572984
21MP0002420_abnormal_adaptive_immunity2.44995976
22MP0001819_abnormal_immune_cell2.44091314
23MP0002405_respiratory_system_inflammati2.34216308
24MP0005464_abnormal_platelet_physiology2.32925507
25MP0003300_gastrointestinal_ulcer2.09973942
26MP0001533_abnormal_skeleton_physiology2.03601611
27MP0001853_heart_inflammation2.02010749
28MP0005058_abnormal_lysosome_morphology1.99361789
29MP0009278_abnormal_bone_marrow1.96597613
30MP0009840_abnormal_foam_cell1.94340285
31MP0002398_abnormal_bone_marrow1.93900834
32MP0009333_abnormal_splenocyte_physiolog1.90762075
33MP0000716_abnormal_immune_system1.90192466
34MP0000343_altered_response_to1.89021039
35MP0001845_abnormal_inflammatory_respons1.87646756
36MP0003172_abnormal_lysosome_physiology1.86233251
37MP0000465_gastrointestinal_hemorrhage1.80548601
38MP0010155_abnormal_intestine_physiology1.79612296
39MP0004947_skin_inflammation1.72122166
40MP0002396_abnormal_hematopoietic_system1.70522025
41MP0001545_abnormal_hematopoietic_system1.67974686
42MP0005397_hematopoietic_system_phenotyp1.67974686
43MP0003448_altered_tumor_morphology1.65035736
44MP0008260_abnormal_autophagy1.63830293
45MP0002006_tumorigenesis1.63764847
46MP0002166_altered_tumor_susceptibility1.63321104
47MP0000689_abnormal_spleen_morphology1.62060286
48MP0005076_abnormal_cell_differentiation1.61894786
49MP0002722_abnormal_immune_system1.60056821
50MP0002429_abnormal_blood_cell1.58716679
51MP0005310_abnormal_salivary_gland1.56400771
52MP0003763_abnormal_thymus_physiology1.56034242
53MP0008469_abnormal_protein_level1.53829155
54MP0001851_eye_inflammation1.47250580
55MP0001873_stomach_inflammation1.43972319
56MP0000858_altered_metastatic_potential1.42880891
57MP0009764_decreased_sensitivity_to1.42748532
58MP0005451_abnormal_body_composition1.33542641
59MP0004808_abnormal_hematopoietic_stem1.33218576
60MP0002998_abnormal_bone_remodeling1.29453655
61MP0003075_altered_response_to1.21427047
62MP0002139_abnormal_hepatobiliary_system1.16267110
63MP0003828_pulmonary_edema1.15874445
64MP0000703_abnormal_thymus_morphology1.15048545
65MP0005166_decreased_susceptibility_to1.14235600
66MP0010307_abnormal_tumor_latency1.13238385
67MP0002933_joint_inflammation1.09930426
68MP0003866_abnormal_defecation1.08763856
69MP0000490_abnormal_crypts_of1.07734428
70MP0002332_abnormal_exercise_endurance1.06180905
71MP0003806_abnormal_nucleotide_metabolis1.03717120
72MP0005174_abnormal_tail_pigmentation1.01346667
73MP0002254_reproductive_system_inflammat1.00867430
74MP0005390_skeleton_phenotype0.98931887
75MP0000604_amyloidosis0.96094357
76MP0003566_abnormal_cell_adhesion0.92792934
77MP0010352_gastrointestinal_tract_polyps0.92010622
78MP0002138_abnormal_hepatobiliary_system0.91171351
79MP0008057_abnormal_DNA_replication0.87983791
80MP0003690_abnormal_glial_cell0.87001628
81MP0009763_increased_sensitivity_to0.83031620
82MP0000249_abnormal_blood_vessel0.81360839
83MP0005167_abnormal_blood-brain_barrier0.78830377
84MP0005023_abnormal_wound_healing0.78656784
85MP0003183_abnormal_peptide_metabolism0.77841549
86MP0003453_abnormal_keratinocyte_physiol0.77084341
87MP0005164_abnormal_response_to0.76952288
88MP0001663_abnormal_digestive_system0.76865711
89MP0002019_abnormal_tumor_incidence0.74067180
90MP0008873_increased_physiological_sensi0.73363929
91MP0001727_abnormal_embryo_implantation0.71352983
92MP0006054_spinal_hemorrhage0.71176299
93MP0003221_abnormal_cardiomyocyte_apopto0.70943455
94MP0003795_abnormal_bone_structure0.68835110
95MP0004883_abnormal_blood_vessel0.66656224
96MP0001915_intracranial_hemorrhage0.66496437
97MP0002132_abnormal_respiratory_system0.66453189
98MP0003045_fibrosis0.63796684
99MP0000750_abnormal_muscle_regeneration0.63344711
100MP0005535_abnormal_body_temperature0.60552952
101MP0000569_abnormal_digit_pigmentation0.59325407
102MP0002277_abnormal_respiratory_mucosa0.57620623
103MP0000609_abnormal_liver_physiology0.57246001
104MP0005165_increased_susceptibility_to0.54376518
105MP0009765_abnormal_xenobiotic_induced0.53662351
106MP0000371_diluted_coat_color0.52461989
107MP0008874_decreased_physiological_sensi0.52082527
108MP0005319_abnormal_enzyme/_coenzyme0.51078951
109MP0003656_abnormal_erythrocyte_physiolo0.49797166
110MP0002136_abnormal_kidney_physiology0.49128423
111MP0005666_abnormal_adipose_tissue0.49014660
112MP0002009_preneoplasia0.48806575
113MP0008007_abnormal_cellular_replicative0.48784502
114MP0004484_altered_response_of0.48499344
115MP0003077_abnormal_cell_cycle0.47762371
116MP0000313_abnormal_cell_death0.47296369
117MP0003279_aneurysm0.46984151

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.82772420
2Eczematoid dermatitis (HP:0000976)6.30467750
3Recurrent bacterial skin infections (HP:0005406)6.15137455
4Recurrent gram-negative bacterial infections (HP:0005420)4.90281861
5Abnormality of macrophages (HP:0004311)4.59009370
6Myositis (HP:0100614)4.50361847
7Recurrent fungal infections (HP:0002841)4.48811577
8Elevated erythrocyte sedimentation rate (HP:0003565)4.31712856
9Recurrent skin infections (HP:0001581)4.14449314
10Orchitis (HP:0100796)4.10217913
11Mediastinal lymphadenopathy (HP:0100721)4.04451158
12Stomatitis (HP:0010280)4.03075397
13Chronic obstructive pulmonary disease (HP:0006510)3.85862227
14Obstructive lung disease (HP:0006536)3.85862227
15Optic neuritis (HP:0100653)3.75165586
16Retrobulbar optic neuritis (HP:0100654)3.75165586
17Chronic otitis media (HP:0000389)3.72844981
18Increased cerebral lipofuscin (HP:0011813)3.62791584
19Pustule (HP:0200039)3.60245334
20Petechiae (HP:0000967)3.59797050
21Recurrent viral infections (HP:0004429)3.59077754
22Increased neuronal autofluorescent lipopigment (HP:0002074)3.53232953
23Chronic mucocutaneous candidiasis (HP:0002728)3.46887849
24Recurrent cutaneous fungal infections (HP:0011370)3.46887849
25Gingivitis (HP:0000230)3.46080873
26Amyloidosis (HP:0011034)3.45768491
27Nasal polyposis (HP:0100582)3.32733111
28Cellulitis (HP:0100658)3.31792453
29Systemic lupus erythematosus (HP:0002725)3.31061901
30IgM deficiency (HP:0002850)3.28289016
31Impaired platelet aggregation (HP:0003540)3.24230859
32Abnormal platelet function (HP:0011869)3.24230859
33Prolonged bleeding time (HP:0003010)3.23383151
34Spontaneous hematomas (HP:0007420)3.18533276
35Abnormality of glycolipid metabolism (HP:0010969)3.17377439
36Abnormality of liposaccharide metabolism (HP:0010968)3.17377439
37Abnormality of glycosphingolipid metabolism (HP:0004343)3.17377439
38Episodic fever (HP:0001954)3.08773833
39Vacuolated lymphocytes (HP:0001922)3.07591549
40Gangrene (HP:0100758)3.06129886
41Meningitis (HP:0001287)3.00718470
42Vasculitis (HP:0002633)2.97900533
43Periodontitis (HP:0000704)2.96209264
44Prostate neoplasm (HP:0100787)2.91480188
45Abnormality of the nasal mucosa (HP:0000433)2.90251933
46Inflammation of the large intestine (HP:0002037)2.88473058
47Gingival bleeding (HP:0000225)2.81768248
48Leukocytosis (HP:0001974)2.81511780
49Epistaxis (HP:0000421)2.78947370
50Gastrointestinal inflammation (HP:0004386)2.75049957
51Recurrent bronchitis (HP:0002837)2.74747540
52T lymphocytopenia (HP:0005403)2.73628153
53Abnormality of T cell number (HP:0011839)2.73307250
54Increased serum ferritin (HP:0003281)2.72959408
55Pulmonary embolism (HP:0002204)2.70783889
56Loss of speech (HP:0002371)2.69916335
57Glomerulonephritis (HP:0000099)2.66945023
58Urticaria (HP:0001025)2.63646261
59Autoimmune thrombocytopenia (HP:0001973)2.61268750
60Pulmonary infiltrates (HP:0002113)2.60173022
61Colitis (HP:0002583)2.57723673
62Agnosia (HP:0010524)2.56644417
63Purpura (HP:0000979)2.56557022
64Abnormality of T cells (HP:0002843)2.56151660
65Hematochezia (HP:0002573)2.55533677
66Abnormality of the pleura (HP:0002103)2.54013586
67Autoimmune hemolytic anemia (HP:0001890)2.53215963
68Arterial thrombosis (HP:0004420)2.52907987
69Disinhibition (HP:0000734)2.52020963
70Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.51983668
71Axonal loss (HP:0003447)2.51316918
72Hemoptysis (HP:0002105)2.47223385
73Dysostosis multiplex (HP:0000943)2.44916353
74Basal ganglia calcification (HP:0002135)2.44756218
75Osteolytic defects of the hand bones (HP:0009699)2.44318094
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.44318094
77Abnormal delayed hypersensitivity skin test (HP:0002963)2.43901812
78Glomerulopathy (HP:0100820)2.41687726
79Interstitial pulmonary disease (HP:0006530)2.40922730
80Granulocytopenia (HP:0001913)2.39299205
81Chronic diarrhea (HP:0002028)2.38018454
82Myocardial infarction (HP:0001658)2.37097833
83Cheilitis (HP:0100825)2.36402030
84Abnormality of T cell physiology (HP:0011840)2.36168374
85Vertigo (HP:0002321)2.35507030
86Polyneuropathy (HP:0001271)2.34261291
87Abnormality of the peritoneum (HP:0002585)2.33560646
88Abnormality of the prostate (HP:0008775)2.33483966
89Keratoconjunctivitis sicca (HP:0001097)2.29773602
90Menorrhagia (HP:0000132)2.27929055
91Abnormality of iron homeostasis (HP:0011031)2.27024766
92Abnormality of the endocardium (HP:0004306)2.26687401
93Osteomyelitis (HP:0002754)2.25527349
94Keratitis (HP:0000491)2.21740283
95Peritonitis (HP:0002586)2.21462875
96Segmental peripheral demyelination/remyelination (HP:0003481)2.21448982
97Increased IgE level (HP:0003212)2.18142786
98Panhypogammaglobulinemia (HP:0003139)2.17741800
99Abnormal platelet volume (HP:0011876)2.15875161
100Encephalitis (HP:0002383)2.15609500
101Chest pain (HP:0100749)2.14076835
102Acne (HP:0001061)2.12386602
103Premature loss of primary teeth (HP:0006323)2.12064365
104Thrombocytosis (HP:0001894)2.09242382
105Anorexia (HP:0002039)2.08415363
106Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06651013
107Abnormality of polysaccharide metabolism (HP:0011012)2.06651013
108Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06651013
109Gastrointestinal infarctions (HP:0005244)2.06632285
110Eosinophilia (HP:0001880)2.06122892
111Keratoconjunctivitis (HP:0001096)2.05552409
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.05512444
113Abnormality of eosinophils (HP:0001879)2.03001747
114Combined immunodeficiency (HP:0005387)2.02463337
115Hypergammaglobulinemia (HP:0010702)2.02188850
116Skin ulcer (HP:0200042)2.01611120
117Joint swelling (HP:0001386)1.99883224
118Thyroiditis (HP:0100646)1.98316946
119Increased IgM level (HP:0003496)1.97704833
120Recurrent pneumonia (HP:0006532)1.97481179
121Arthralgia (HP:0002829)1.97209934
122Mucopolysacchariduria (HP:0008155)1.96340121
123Urinary glycosaminoglycan excretion (HP:0003541)1.96340121
124Thick nail (HP:0001805)1.96001702
125Thrombophlebitis (HP:0004418)1.92198597
126Polygenic inheritance (HP:0010982)1.89897155
127Sepsis (HP:0100806)1.89803356
128Hepatosplenomegaly (HP:0001433)1.89748539
129Increased CSF protein (HP:0002922)1.87704770
130Abnormality of transition element cation homeostasis (HP:0011030)1.85620306
131Skin rash (HP:0000988)1.84302116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.61946463
2MAP3K143.21238497
3BLK3.12656825
4TYK23.09356622
5TXK3.09061556
6TBK12.83005412
7IKBKE2.72090310
8KIT2.61183249
9PRPF4B2.42610328
10JAK32.28704111
11IKBKB2.17687112
12IRAK12.17022662
13RIPK42.15249637
14ZAP702.13522413
15ERN12.11016897
16MAP3K102.09411594
17PIM22.07259530
18IRAK42.03467125
19STK101.96022156
20TAOK21.94313745
21IRAK31.93625696
22IRAK21.92724873
23TGFBR21.92319224
24GRK61.88924506
25JAK11.85455398
26PIM11.82662580
27EPHB11.62990058
28MAP3K11.61073023
29CSK1.60444543
30BMPR21.59516075
31FGFR41.54757948
32CSF1R1.50216443
33SYK1.43013339
34FES1.41123337
35MATK1.39069173
36ITK1.37376967
37NEK91.36327661
38BTK1.35778578
39FGFR31.34759939
40CHUK1.26647914
41HCK1.24015153
42EEF2K1.23183729
43RPS6KA41.23167116
44JAK21.18649798
45LCK1.17843528
46TNK21.15471582
47TEC1.14997906
48LYN1.12425951
49TAOK31.03124868
50TRIB31.00286277
51KSR20.98825662
52PIK3CG0.97779909
53TESK20.96388128
54MAP2K30.95666649
55SCYL20.94286622
56SIK30.93641140
57CDK120.92720376
58CLK10.91392420
59CDK60.90724391
60CDC42BPA0.89878121
61MAP3K110.88292718
62MAP3K50.85927269
63MAP3K130.84866779
64MST40.83539382
65BMX0.82606999
66LRRK20.82167019
67KDR0.79387900
68FGR0.78263073
69PAK40.75798503
70PDK20.74361313
71MARK30.72711040
72RPS6KA60.71490597
73MAP3K60.68574205
74MAPK70.65963854
75MAPKAPK20.64849014
76GRK70.63659382
77SIK20.61464360
78MAPK40.59128737
79RPS6KL10.59082951
80RPS6KC10.59082951
81NME20.58905919
82MAP2K60.55865236
83PKN20.54861893
84RPS6KA50.54515643
85TRPM70.52056356
86MAP3K30.51072531
87MARK20.50010369
88EGFR0.48866118
89ACVR1B0.47992427
90STK240.47729590
91PDK10.47699850
92NEK20.47663856
93STK40.47546462
94PRKCD0.47250304
95PDPK10.46604888
96MAP2K20.45116720
97DDR20.44731343
98HIPK20.44099970
99TAOK10.43010140
100ABL20.42644698
101ABL10.41630923
102PTK60.40704921
103RAF10.40438408
104ALK0.40141957
105FYN0.39309079
106MAP3K80.39260762
107MOS0.39188161
108CAMK1D0.39033661
109DMPK0.39029723
110DAPK20.37885418
111CDK40.37566189
112FLT30.37464459
113PRKCQ0.35355322
114RPS6KA10.35012703
115MAPK120.33293514
116PRKD20.33263039
117EPHA30.32613942
118YES10.32317327
119TSSK60.32021242
120EIF2AK20.31594645
121RIPK10.30276892
122MAPK110.29767466
123MAPK30.27509675
124ARAF0.27052804
125MAP3K20.26648698
126GSK3A0.25925337
127PRKAA20.24058958
128PRKG20.23432042

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.45113269
2Leishmaniasis_Homo sapiens_hsa051403.19054809
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.90801835
4Staphylococcus aureus infection_Homo sapiens_hsa051502.73188686
5Osteoclast differentiation_Homo sapiens_hsa043802.61773931
6Legionellosis_Homo sapiens_hsa051342.55800956
7Allograft rejection_Homo sapiens_hsa053302.39610742
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.31973374
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.27758172
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.22032587
11Measles_Homo sapiens_hsa051622.08852740
12B cell receptor signaling pathway_Homo sapiens_hsa046622.08414674
13Graft-versus-host disease_Homo sapiens_hsa053322.08103853
14Tuberculosis_Homo sapiens_hsa051522.04853813
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91041450
16Hematopoietic cell lineage_Homo sapiens_hsa046401.89512398
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.86601747
18Pertussis_Homo sapiens_hsa051331.83354595
19Primary immunodeficiency_Homo sapiens_hsa053401.77064327
20Malaria_Homo sapiens_hsa051441.75203375
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.73782638
22Lysosome_Homo sapiens_hsa041421.70973356
23Antigen processing and presentation_Homo sapiens_hsa046121.69285155
24Toxoplasmosis_Homo sapiens_hsa051451.67802198
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67415069
26Other glycan degradation_Homo sapiens_hsa005111.65304935
27* Jak-STAT signaling pathway_Homo sapiens_hsa046301.60441068
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59570487
29Apoptosis_Homo sapiens_hsa042101.58246558
30TNF signaling pathway_Homo sapiens_hsa046681.56501422
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.55223914
32Shigellosis_Homo sapiens_hsa051311.53621268
33Chemokine signaling pathway_Homo sapiens_hsa040621.49389639
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49232543
35Salmonella infection_Homo sapiens_hsa051321.48584688
36Herpes simplex infection_Homo sapiens_hsa051681.48201528
37Influenza A_Homo sapiens_hsa051641.47729279
38Rheumatoid arthritis_Homo sapiens_hsa053231.46957525
39T cell receptor signaling pathway_Homo sapiens_hsa046601.45801417
40* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40668272
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.39495659
42Autoimmune thyroid disease_Homo sapiens_hsa053201.27926636
43Hepatitis B_Homo sapiens_hsa051611.26808783
44Type I diabetes mellitus_Homo sapiens_hsa049401.23637253
45Phagosome_Homo sapiens_hsa041451.20834284
46Viral myocarditis_Homo sapiens_hsa054161.19820784
47Acute myeloid leukemia_Homo sapiens_hsa052211.14559861
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14557768
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.09525966
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08639315
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03437058
52Chronic myeloid leukemia_Homo sapiens_hsa052201.03367219
53Platelet activation_Homo sapiens_hsa046110.96023170
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95331801
55Bladder cancer_Homo sapiens_hsa052190.94889477
56Pancreatic cancer_Homo sapiens_hsa052120.93553715
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79839414
58Viral carcinogenesis_Homo sapiens_hsa052030.78916724
59Hepatitis C_Homo sapiens_hsa051600.76909321
60Epstein-Barr virus infection_Homo sapiens_hsa051690.76839217
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75947506
62African trypanosomiasis_Homo sapiens_hsa051430.74918068
63Renin-angiotensin system_Homo sapiens_hsa046140.69480277
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.69267046
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60991566
66Amoebiasis_Homo sapiens_hsa051460.59809961
67Prolactin signaling pathway_Homo sapiens_hsa049170.59683232
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59665702
69Type II diabetes mellitus_Homo sapiens_hsa049300.58694342
70p53 signaling pathway_Homo sapiens_hsa041150.57806739
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57585722
72HTLV-I infection_Homo sapiens_hsa051660.56755589
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55936567
74VEGF signaling pathway_Homo sapiens_hsa043700.55411781
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.54244064
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52195492
77Endocytosis_Homo sapiens_hsa041440.47645713
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46166966
79Small cell lung cancer_Homo sapiens_hsa052220.44979169
80DNA replication_Homo sapiens_hsa030300.44410459
81HIF-1 signaling pathway_Homo sapiens_hsa040660.43374790
82Complement and coagulation cascades_Homo sapiens_hsa046100.41788599
83Notch signaling pathway_Homo sapiens_hsa043300.41602308
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41532774
85Colorectal cancer_Homo sapiens_hsa052100.41219634
86GnRH signaling pathway_Homo sapiens_hsa049120.40464346
87Base excision repair_Homo sapiens_hsa034100.39197660
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.39042704
89MicroRNAs in cancer_Homo sapiens_hsa052060.38504525
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38366788
91Prion diseases_Homo sapiens_hsa050200.37366602
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36476548
93Renal cell carcinoma_Homo sapiens_hsa052110.35661925
94Non-small cell lung cancer_Homo sapiens_hsa052230.32803333
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31570162
96MAPK signaling pathway_Homo sapiens_hsa040100.29879361
97FoxO signaling pathway_Homo sapiens_hsa040680.29535124
98Ribosome_Homo sapiens_hsa030100.27287260
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26310490
100Caffeine metabolism_Homo sapiens_hsa002320.25683973
101Proteoglycans in cancer_Homo sapiens_hsa052050.24371758
102Collecting duct acid secretion_Homo sapiens_hsa049660.22302607
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21482569
104ErbB signaling pathway_Homo sapiens_hsa040120.21236170
105Arachidonic acid metabolism_Homo sapiens_hsa005900.21000319
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.20805778
107Dorso-ventral axis formation_Homo sapiens_hsa043200.20610709
108Choline metabolism in cancer_Homo sapiens_hsa052310.20091011
109Mineral absorption_Homo sapiens_hsa049780.19699994
110Sphingolipid metabolism_Homo sapiens_hsa006000.18977549
111Systemic lupus erythematosus_Homo sapiens_hsa053220.18917759
112Endometrial cancer_Homo sapiens_hsa052130.17493464
113Prostate cancer_Homo sapiens_hsa052150.16558897
114mTOR signaling pathway_Homo sapiens_hsa041500.15526856
115Insulin resistance_Homo sapiens_hsa049310.15415287
116Inositol phosphate metabolism_Homo sapiens_hsa005620.15336085
117Pathways in cancer_Homo sapiens_hsa052000.14317580

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