OSR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1outer ear morphogenesis (GO:0042473)6.89195694
2chondrocyte proliferation (GO:0035988)6.77402892
3protein heterotrimerization (GO:0070208)6.19925357
4bone trabecula formation (GO:0060346)5.72400537
5sequestering of extracellular ligand from receptor (GO:0035581)5.57850314
6collagen fibril organization (GO:0030199)5.54382612
7mesenchymal-epithelial cell signaling (GO:0060638)5.32918860
8axon extension involved in axon guidance (GO:0048846)5.16377098
9neuron projection extension involved in neuron projection guidance (GO:1902284)5.16377098
10embryonic cranial skeleton morphogenesis (GO:0048701)4.92712478
11* middle ear morphogenesis (GO:0042474)4.86900677
12G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.86126739
13planar cell polarity pathway involved in neural tube closure (GO:0090179)4.80297497
14* metanephric mesenchyme development (GO:0072075)4.55283499
15craniofacial suture morphogenesis (GO:0097094)4.53007666
16regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.47996770
17* kidney mesenchyme development (GO:0072074)4.40899106
18negative regulation of chondrocyte differentiation (GO:0032331)4.40492733
19cell migration involved in heart development (GO:0060973)4.39204918
20type B pancreatic cell proliferation (GO:0044342)4.28492628
21cartilage morphogenesis (GO:0060536)4.10803868
22mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.03856844
23extracellular regulation of signal transduction (GO:1900115)3.99300312
24extracellular negative regulation of signal transduction (GO:1900116)3.99300312
25dermatan sulfate biosynthetic process (GO:0030208)3.90140094
26regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.88881764
27negative regulation of cartilage development (GO:0061037)3.67705287
28regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.64104992
29regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.62719121
30keratan sulfate catabolic process (GO:0042340)3.61021367
31cochlea morphogenesis (GO:0090103)3.60860710
32dermatan sulfate metabolic process (GO:0030205)3.60052658
33paraxial mesoderm development (GO:0048339)3.59302269
34negative regulation of embryonic development (GO:0045992)3.56242553
35cranial suture morphogenesis (GO:0060363)3.55719710
36collagen metabolic process (GO:0032963)3.54468673
37* cell proliferation involved in metanephros development (GO:0072203)3.52945224
38regulation of heart morphogenesis (GO:2000826)3.51037991
39positive regulation of smoothened signaling pathway (GO:0045880)3.49949265
40hemidesmosome assembly (GO:0031581)3.49147215
41endodermal cell differentiation (GO:0035987)3.48315156
42negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.46539049
43extracellular fibril organization (GO:0043206)3.46425707
44positive regulation of mesenchymal cell proliferation (GO:0002053)3.45721398
45collagen catabolic process (GO:0030574)3.42961209
46endocardial cushion development (GO:0003197)3.42518307
47regulation of mesenchymal cell proliferation (GO:0010464)3.42166098
48proximal/distal pattern formation (GO:0009954)3.41728229
49positive regulation of epithelial to mesenchymal transition (GO:0010718)3.40210746
50negative regulation of fatty acid transport (GO:2000192)3.38967969
51peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.36842735
52vascular endothelial growth factor signaling pathway (GO:0038084)3.35382085
53* embryonic skeletal joint morphogenesis (GO:0060272)3.33137686
54* embryonic skeletal system morphogenesis (GO:0048704)3.33027661
55muscle cell migration (GO:0014812)3.31022880
56regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.28866925
57multicellular organismal macromolecule metabolic process (GO:0044259)3.27651413
58lymph vessel development (GO:0001945)3.27229332
59hippo signaling (GO:0035329)3.26822221
60negative regulation of stem cell proliferation (GO:2000647)3.25153358
61glomerular basement membrane development (GO:0032836)3.24095579
62lung vasculature development (GO:0060426)3.24084835
63negative regulation of smooth muscle cell migration (GO:0014912)3.23405875
64Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.23340543
65regulation of non-canonical Wnt signaling pathway (GO:2000050)3.22591361
66* mesenchymal cell proliferation (GO:0010463)3.21023073
67* embryonic forelimb morphogenesis (GO:0035115)3.19389332
68cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.17872804
69skin morphogenesis (GO:0043589)3.17465317
70regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.16739682
71regulation of cardioblast proliferation (GO:0003264)3.15710591
72regulation of secondary heart field cardioblast proliferation (GO:0003266)3.15710591
73extracellular matrix assembly (GO:0085029)3.14955631
74* cell proliferation involved in kidney development (GO:0072111)3.13741343
75regulation of tight junction assembly (GO:2000810)3.13580434
76* mesenchymal cell differentiation involved in kidney development (GO:0072161)3.11164060
77* mesenchymal cell differentiation involved in renal system development (GO:2001012)3.11164060
78metanephros development (GO:0001656)3.10716970
79regulation of establishment of planar polarity (GO:0090175)3.10503446
80barbed-end actin filament capping (GO:0051016)3.09888531
81positive regulation of endothelial cell apoptotic process (GO:2000353)3.09878849
82multicellular organismal metabolic process (GO:0044236)3.09012788
83multicellular organismal catabolic process (GO:0044243)3.08233596
84negative regulation of axon extension involved in axon guidance (GO:0048843)3.07934173
85neural crest cell development (GO:0014032)3.06305149
86virion attachment to host cell (GO:0019062)3.05338376
87adhesion of symbiont to host cell (GO:0044650)3.05338376
88tooth mineralization (GO:0034505)3.04006797
89regulation of cartilage development (GO:0061035)3.03990640
90fibril organization (GO:0097435)3.03989565
91glial cell migration (GO:0008347)3.02757750
92endothelial cell morphogenesis (GO:0001886)3.01724791
93negative regulation of catenin import into nucleus (GO:0035414)3.01032874
94facial nerve structural organization (GO:0021612)2.99528720
95regulation of chondrocyte differentiation (GO:0032330)2.99450704
96cellular response to vitamin (GO:0071295)2.96698013
97organ induction (GO:0001759)2.96197503
98regulation of organ formation (GO:0003156)2.95683876
99protein localization to cell surface (GO:0034394)2.94977977
100negative regulation of BMP signaling pathway (GO:0030514)2.94765488
101glomerular visceral epithelial cell development (GO:0072015)2.94483017
102negative chemotaxis (GO:0050919)2.93372262
103lateral sprouting from an epithelium (GO:0060601)2.91885769
104regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.91629289
105outflow tract septum morphogenesis (GO:0003148)2.91431954
106ganglion development (GO:0061548)2.90712835
107basement membrane organization (GO:0071711)2.89903459
108* skeletal system morphogenesis (GO:0048705)2.89436633
109* embryonic appendage morphogenesis (GO:0035113)2.88200955
110* embryonic limb morphogenesis (GO:0030326)2.88200955
111extracellular matrix organization (GO:0030198)2.88059354
112* forelimb morphogenesis (GO:0035136)2.87384014
113extracellular structure organization (GO:0043062)2.87029339
114desmosome organization (GO:0002934)2.86371485
115* mesonephros development (GO:0001823)2.85849797
116peptidyl-proline hydroxylation (GO:0019511)2.84722404
117regulation of type B pancreatic cell apoptotic process (GO:2000674)2.84201307
118positive regulation of cartilage development (GO:0061036)2.84095034
119pericardium development (GO:0060039)2.83297128
120extracellular matrix disassembly (GO:0022617)2.83202969
121epithelial to mesenchymal transition (GO:0001837)2.83030629
122chondrocyte development (GO:0002063)2.82644577
123negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.82521141
124epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.82225736
125eyelid development in camera-type eye (GO:0061029)2.81835446
126body morphogenesis (GO:0010171)2.81020639
127non-canonical Wnt signaling pathway (GO:0035567)2.80364679
128mesenchymal to epithelial transition (GO:0060231)2.80286728
129anatomical structure regression (GO:0060033)2.79542772
130regulation of cardioblast differentiation (GO:0051890)2.78671490
131cranial nerve morphogenesis (GO:0021602)2.75953909
132substrate-dependent cell migration (GO:0006929)2.73289646
133blood vessel maturation (GO:0001955)2.71545451
134cell-substrate junction assembly (GO:0007044)2.70748020
135venous blood vessel morphogenesis (GO:0048845)2.68534225
136* smooth muscle tissue development (GO:0048745)2.66971210
137aorta morphogenesis (GO:0035909)2.61694662
138protein hydroxylation (GO:0018126)2.57715662
139regulation of integrin-mediated signaling pathway (GO:2001044)2.55835381
140substrate adhesion-dependent cell spreading (GO:0034446)2.54618411
141adhesion of symbiont to host (GO:0044406)2.54612211
142glomerular epithelial cell development (GO:0072310)2.54607771
143peptide cross-linking (GO:0018149)2.53361136
144myoblast migration (GO:0051451)2.51686484
145cellular response to amino acid stimulus (GO:0071230)2.51529681
146cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.51073295
147lymphangiogenesis (GO:0001946)2.49933693
148regulation of extracellular matrix disassembly (GO:0010715)2.49560409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.29865554
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.69033521
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.42239013
4* RARG_19884340_ChIP-ChIP_MEFs_Mouse4.29647240
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.11787519
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.42947117
7* EED_16625203_ChIP-ChIP_MESCs_Mouse3.35940417
8* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse3.21900249
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.91572945
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.90472944
11* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.87247988
12* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.81653524
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.67947756
14CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.67285695
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.64974216
16* TP53_20018659_ChIP-ChIP_R1E_Mouse2.56970241
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.50914519
18* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47123361
19* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47123361
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.46159563
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.45127018
22* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.43142397
23* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.36902688
24CJUN_26792858_Chip-Seq_BT549_Human2.30590036
25* BRD4_25478319_ChIP-Seq_HGPS_Human2.29551549
26* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26926529
27* EZH2_27304074_Chip-Seq_ESCs_Mouse2.19973912
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14790473
29* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07940639
30* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07172956
31* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06007330
32CLOCK_20551151_ChIP-Seq_293T_Human2.00020956
33* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98053785
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.82593777
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.82593777
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.80952573
37* EP300_21415370_ChIP-Seq_HL-1_Mouse1.77304311
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76090575
39* TP53_18474530_ChIP-ChIP_U2OS_Human1.74963880
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73836446
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70591512
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68439036
43* RNF2_27304074_Chip-Seq_ESCs_Mouse1.68311501
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65490647
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63965230
46SMC1_22415368_ChIP-Seq_MEFs_Mouse1.62992606
47* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61412092
48* SA1_22415368_ChIP-Seq_MEFs_Mouse1.54841074
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.53696140
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.52598886
51* CBX2_27304074_Chip-Seq_ESCs_Mouse1.51406251
52P63_26484246_Chip-Seq_KERATINOCYTES_Human1.48057085
53* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47124436
54ISL1_27105846_Chip-Seq_CPCs_Mouse1.46400959
55TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.46372077
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.44264025
57* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41974675
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37705965
59ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.35628868
60* RING1B_27294783_Chip-Seq_NPCs_Mouse1.35277426
61* ELK3_25401928_ChIP-Seq_HUVEC_Human1.33502420
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.31685937
63TP53_16413492_ChIP-PET_HCT116_Human1.31150421
64LXR_22292898_ChIP-Seq_THP-1_Human1.30150028
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29765115
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29765115
67RAD21_21589869_ChIP-Seq_MESCs_Mouse1.28786516
68* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25823764
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24216306
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.23723711
71TBX20_22328084_ChIP-Seq_HEART_Mouse1.23723711
72* UBF1/2_26484160_Chip-Seq_HMECs_Human1.23456245
73* RING1B_27294783_Chip-Seq_ESCs_Mouse1.20925405
74TP53_23651856_ChIP-Seq_MEFs_Mouse1.19744520
75MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.19405893
76* EZH2_27294783_Chip-Seq_ESCs_Mouse1.18854550
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17714463
78* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17090746
79* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16905107
80SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16368589
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16280520
82* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15627396
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15442536
84TET1_21490601_ChIP-Seq_MESCs_Mouse1.14368414
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13646991
86* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.13452338
87* NANOG_16153702_ChIP-ChIP_HESCs_Human1.12764698
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12584098
89RACK7_27058665_Chip-Seq_MCF-7_Human1.12484644
90FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11037091
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10736457
92NFI_21473784_ChIP-Seq_ESCs_Mouse1.10148929
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09707194
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09531802
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09185874
96* RXR_22108803_ChIP-Seq_LS180_Human1.08635331
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07989856
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07451143
99TP53_22127205_ChIP-Seq_IMR90_Human1.07284497
100TP63_22573176_ChIP-Seq_HFKS_Human1.07062305
101NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02548137
102NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01397152
103CTCF_27219007_Chip-Seq_Bcells_Human1.00585334
104* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00562609
105* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99858242
106STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97932484
107CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96978215
108CSB_26484114_Chip-Seq_FIBROBLAST_Human0.96669603
109PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96657079
110* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96605211
111* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95440085
112* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95028442
113SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93435982
114PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.92104384
115ATF3_27146783_Chip-Seq_COLON_Human0.91784426
116* AHR_22903824_ChIP-Seq_MCF-7_Human0.91770814
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91592274
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91373506
119* ARNT_22903824_ChIP-Seq_MCF-7_Human0.90621619
120* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88632108
121GBX2_23144817_ChIP-Seq_PC3_Human0.88337908
122* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88030255
123SOX2_20726797_ChIP-Seq_SW620_Human0.87966602
124PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.87292401
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86598887
126EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86203663
127* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86005590
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83302379
129* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82011569
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79981446
131ESR1_21235772_ChIP-Seq_MCF-7_Human0.79638705

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.77035474
2MP0005503_abnormal_tendon_morphology5.13347067
3MP0005275_abnormal_skin_tensile4.13551534
4MP0010030_abnormal_orbit_morphology3.31996054
5MP0003279_aneurysm3.08448847
6MP0003705_abnormal_hypodermis_morpholog2.92312804
7MP0009250_abnormal_appendicular_skeleto2.81073058
8MP0003385_abnormal_body_wall2.79554553
9MP0001958_emphysema2.63189549
10MP0000049_abnormal_middle_ear2.43495999
11MP0002249_abnormal_larynx_morphology2.43350356
12MP0005257_abnormal_intraocular_pressure2.35464924
13MP0005508_abnormal_skeleton_morphology2.30107227
14* MP0003942_abnormal_urinary_system2.30001028
15MP0005623_abnormal_meninges_morphology2.26340526
16MP0004272_abnormal_basement_membrane2.23543138
17MP0003122_maternal_imprinting2.11045970
18MP0000534_abnormal_ureter_morphology2.06373697
19MP0009384_cardiac_valve_regurgitation2.03440559
20MP0006054_spinal_hemorrhage1.92102167
21MP0000751_myopathy1.88779800
22MP0003755_abnormal_palate_morphology1.83666778
23MP0009053_abnormal_anal_canal1.78488511
24MP0003950_abnormal_plasma_membrane1.77950726
25MP0002932_abnormal_joint_morphology1.75011915
26MP0003941_abnormal_skin_development1.74358814
27MP0002938_white_spotting1.70095358
28MP0000733_abnormal_muscle_development1.66055575
29MP0009780_abnormal_chondrocyte_physiolo1.64209920
30MP0002282_abnormal_trachea_morphology1.61372024
31MP0000428_abnormal_craniofacial_morphol1.60498775
32MP0002060_abnormal_skin_morphology1.59429879
33MP0000678_abnormal_parathyroid_gland1.58386471
34MP0002108_abnormal_muscle_morphology1.54605160
35MP0000163_abnormal_cartilage_morphology1.49312406
36MP0003123_paternal_imprinting1.47061719
37MP0003937_abnormal_limbs/digits/tail_de1.45152887
38MP0010368_abnormal_lymphatic_system1.44688662
39MP0002115_abnormal_skeleton_extremities1.41593653
40MP0004134_abnormal_chest_morphology1.39284890
41MP0003115_abnormal_respiratory_system1.38450203
42MP0002116_abnormal_craniofacial_bone1.36876220
43MP0000516_abnormal_urinary_system1.36543094
44MP0005367_renal/urinary_system_phenotyp1.36543094
45MP0002295_abnormal_pulmonary_circulatio1.35281565
46MP0002177_abnormal_outer_ear1.33156807
47MP0002109_abnormal_limb_morphology1.32262782
48MP0000566_synostosis1.30595898
49MP0005023_abnormal_wound_healing1.30020798
50MP0002233_abnormal_nose_morphology1.29918367
51MP0003091_abnormal_cell_migration1.29693824
52MP0003935_abnormal_craniofacial_develop1.28969160
53MP0001299_abnormal_eye_distance/1.26324461
54MP0000762_abnormal_tongue_morphology1.23462558
55MP0001879_abnormal_lymphatic_vessel1.23096184
56MP0000767_abnormal_smooth_muscle1.21326223
57MP0001243_abnormal_dermal_layer1.20251490
58MP0002896_abnormal_bone_mineralization1.19380610
59MP0002113_abnormal_skeleton_development1.17592101
60MP0005410_abnormal_fertilization1.15930157
61MP0005390_skeleton_phenotype1.12160650
62MP0003566_abnormal_cell_adhesion1.11091004
63MP0005248_abnormal_Harderian_gland1.09692395
64MP0010386_abnormal_urinary_bladder1.06480000
65MP0005670_abnormal_white_adipose1.06100608
66MP0000432_abnormal_head_morphology1.05782927
67MP0005171_absent_coat_pigmentation1.05451167
68MP0000537_abnormal_urethra_morphology1.04479254
69MP0002114_abnormal_axial_skeleton1.04299593
70MP0003121_genomic_imprinting1.01560855
71MP0004858_abnormal_nervous_system0.99076136
72MP0001270_distended_abdomen0.98552401
73MP0005076_abnormal_cell_differentiation0.98264133
74MP0000749_muscle_degeneration0.95882156
75MP0002111_abnormal_tail_morphology0.95666683
76MP0001346_abnormal_lacrimal_gland0.95481988
77MP0003283_abnormal_digestive_organ0.94092389
78MP0003938_abnormal_ear_development0.93945876
79MP0001542_abnormal_bone_strength0.92555669
80MP0004233_abnormal_muscle_weight0.91157301
81* MP0001175_abnormal_lung_morphology0.85727138
82MP0000467_abnormal_esophagus_morphology0.83943236
83MP0005197_abnormal_uvea_morphology0.83282237
84MP0001177_atelectasis0.83207761
85MP0001849_ear_inflammation0.83122026
86MP0004084_abnormal_cardiac_muscle0.82286554
87MP0001340_abnormal_eyelid_morphology0.82221055
88MP0006138_congestive_heart_failure0.81064055
89MP0002933_joint_inflammation0.79308223
90MP0001293_anophthalmia0.78348874
91MP0000681_abnormal_thyroid_gland0.77624740
92MP0002089_abnormal_postnatal_growth/wei0.75901844
93MP0005164_abnormal_response_to0.75050675
94* MP0001614_abnormal_blood_vessel0.74770744
95* MP0002925_abnormal_cardiovascular_devel0.74432201
96MP0005375_adipose_tissue_phenotype0.74312170
97MP0005388_respiratory_system_phenotype0.71774069
98MP0002133_abnormal_respiratory_system0.71774069
99MP0002168_other_aberrant_phenotype0.71615196
100MP0000003_abnormal_adipose_tissue0.71558110
101MP0002998_abnormal_bone_remodeling0.71525829
102* MP0002128_abnormal_blood_circulation0.71214613
103MP0001661_extended_life_span0.71133681
104MP0000759_abnormal_skeletal_muscle0.69252719
105MP0008007_abnormal_cellular_replicative0.67646604
106MP0004197_abnormal_fetal_growth/weight/0.67462269
107MP0005620_abnormal_muscle_contractility0.67400076
108MP0010771_integument_phenotype0.66963689
109MP0002092_abnormal_eye_morphology0.66913127
110MP0003795_abnormal_bone_structure0.65571131
111MP0002697_abnormal_eye_size0.65134710
112MP0005369_muscle_phenotype0.64455520
113MP0000462_abnormal_digestive_system0.62920244
114MP0000013_abnormal_adipose_tissue0.62196405
115MP0005595_abnormal_vascular_smooth0.62175444
116MP0000750_abnormal_muscle_regeneration0.62010654
117MP0002234_abnormal_pharynx_morphology0.61635922
118MP0004087_abnormal_muscle_fiber0.61609058
119MP0008004_abnormal_stomach_pH0.61091329
120MP0001286_abnormal_eye_development0.60996122
121MP0001348_abnormal_lacrimal_gland0.60256168
122MP0005377_hearing/vestibular/ear_phenot0.60143866
123MP0000613_abnormal_salivary_gland0.59296049
124MP0008775_abnormal_heart_ventricle0.58863377
125MP0005193_abnormal_anterior_eye0.56543931
126MP0002877_abnormal_melanocyte_morpholog0.56433599
127MP0005165_increased_susceptibility_to0.55377254
128MP0005409_darkened_coat_color0.55046359
129MP0004036_abnormal_muscle_relaxation0.54025340
130MP0005330_cardiomyopathy0.53136090
131MP0001533_abnormal_skeleton_physiology0.51965726
132MP0000230_abnormal_systemic_arterial0.51960587

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.62639535
2Premature rupture of membranes (HP:0001788)6.57292512
3Shallow orbits (HP:0000586)5.13259795
4Ankle contracture (HP:0006466)4.34854673
5Follicular hyperkeratosis (HP:0007502)4.31494431
6Aortic dissection (HP:0002647)4.28158710
7Broad metatarsal (HP:0001783)4.04160005
8Soft skin (HP:0000977)4.03253938
9Abnormality of dentin (HP:0010299)3.81991502
10Neonatal short-limb short stature (HP:0008921)3.64488326
11Bladder diverticulum (HP:0000015)3.62071265
12Vertebral compression fractures (HP:0002953)3.60877361
13Aortic aneurysm (HP:0004942)3.53747925
14Biconcave vertebral bodies (HP:0004586)3.52900911
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.46529670
16Short 4th metacarpal (HP:0010044)3.46529670
17Syringomyelia (HP:0003396)3.45611814
18Spinal cord lesions (HP:0100561)3.45611814
19Peritonitis (HP:0002586)3.44394917
20Atrophic scars (HP:0001075)3.41430482
21Type 1 muscle fiber predominance (HP:0003803)3.39638625
22Cervical subluxation (HP:0003308)3.25858550
23Fragile skin (HP:0001030)3.21399462
24Dilatation of the ascending aorta (HP:0005111)3.15046429
25Short nail (HP:0001799)3.09719846
26Spinal rigidity (HP:0003306)3.02483679
27Cerebral aneurysm (HP:0004944)2.97457508
28Coronal craniosynostosis (HP:0004440)2.89186933
29Blue sclerae (HP:0000592)2.88750130
30Wormian bones (HP:0002645)2.86603560
31Morphological abnormality of the middle ear (HP:0008609)2.84410401
32Abnormality of the 4th metacarpal (HP:0010012)2.79869198
33Joint stiffness (HP:0001387)2.78735626
34Asymmetry of the thorax (HP:0001555)2.77893726
35Wrist flexion contracture (HP:0001239)2.71508778
36Bell-shaped thorax (HP:0001591)2.66470244
37Mesomelia (HP:0003027)2.64048490
38Mitral valve prolapse (HP:0001634)2.63766739
39Genu recurvatum (HP:0002816)2.61459378
40Slender build (HP:0001533)2.61099819
41Osteolytic defects of the hand bones (HP:0009699)2.58791731
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.58791731
43Renal duplication (HP:0000075)2.54037352
44Deviation of the hallux (HP:0010051)2.53679073
45Wide anterior fontanel (HP:0000260)2.52053309
46Vascular tortuosity (HP:0004948)2.50744715
47Bowel diverticulosis (HP:0005222)2.47695360
48Abnormality of the parietal bone (HP:0002696)2.46830910
49Overgrowth (HP:0001548)2.45436652
50Elbow flexion contracture (HP:0002987)2.41638419
51Joint laxity (HP:0001388)2.39629441
52Hyperextensible skin (HP:0000974)2.37637683
53Round ear (HP:0100830)2.36297815
54Hallux valgus (HP:0001822)2.34165793
55Aortic valve stenosis (HP:0001650)2.32712533
56Increased connective tissue (HP:0009025)2.31412127
57Absent eyelashes (HP:0000561)2.29270945
58Abnormality of the phalanges of the hallux (HP:0010057)2.28327357
59Microglossia (HP:0000171)2.25497420
60Broad toe (HP:0001837)2.25493196
61Buphthalmos (HP:0000557)2.19060658
62Mildly elevated creatine phosphokinase (HP:0008180)2.18688137
63Bradycardia (HP:0001662)2.18540455
64Mitral regurgitation (HP:0001653)2.16672264
65Long toe (HP:0010511)2.14012741
66Reduced subcutaneous adipose tissue (HP:0003758)2.13146264
67Entropion (HP:0000621)2.11280479
68Asymmetric septal hypertrophy (HP:0001670)2.10166951
69Arterial tortuosity (HP:0005116)2.09799378
70Delayed cranial suture closure (HP:0000270)2.08588857
71Distal lower limb muscle weakness (HP:0009053)2.07800843
72Abnormal delivery (HP:0001787)2.06634317
73Knee flexion contracture (HP:0006380)2.05068233
74Osteoarthritis (HP:0002758)2.04402546
75Breech presentation (HP:0001623)2.04222634
76Abnormality of the acetabulum (HP:0003170)2.04197027
77Broad long bones (HP:0005622)2.04031833
78Turricephaly (HP:0000262)2.03495898
79Striae distensae (HP:0001065)2.02344516
80Natal tooth (HP:0000695)2.01199450
81Venous abnormality (HP:0002624)1.99726831
82Flat cornea (HP:0007720)1.97861568
83Camptodactyly of toe (HP:0001836)1.97739982
84Distal lower limb amyotrophy (HP:0008944)1.97342830
85Infantile muscular hypotonia (HP:0008947)1.96114007
86Hepatoblastoma (HP:0002884)1.95269013
87Ovoid vertebral bodies (HP:0003300)1.94076646
88Abnormality of the peritoneum (HP:0002585)1.92196863
89Increased corneal curvature (HP:0100692)1.90347503
90Keratoconus (HP:0000563)1.90347503
91Broad ribs (HP:0000885)1.90318242
92Protruding ear (HP:0000411)1.90278162
93Limited hip movement (HP:0008800)1.89518927
94Hypoplasia of the iris (HP:0007676)1.88404655
95Broad hallux (HP:0010055)1.88095597
96Aortic regurgitation (HP:0001659)1.87050835
97Inguinal hernia (HP:0000023)1.86886491
98Partial duplication of the phalanx of hand (HP:0009999)1.86564444
99Venous insufficiency (HP:0005293)1.84587522
100Increased variability in muscle fiber diameter (HP:0003557)1.84045267
101Abnormality of the nasolacrimal system (HP:0000614)1.83628324
102Mitral stenosis (HP:0001718)1.82908516
103Deformed tarsal bones (HP:0008119)1.82897701
104Cardiovascular calcification (HP:0011915)1.82531159
105Abnormality of skeletal muscle fiber size (HP:0012084)1.80917602
106Generalized amyotrophy (HP:0003700)1.80279352
107Upper limb amyotrophy (HP:0009129)1.78352889
108Distal upper limb amyotrophy (HP:0007149)1.78352889
109Glucose intolerance (HP:0000833)1.77096666
110Ectopia lentis (HP:0001083)1.76445756
111Ulnar bowing (HP:0003031)1.76358995
112Alopecia of scalp (HP:0002293)1.76060105
113Midline defect of the nose (HP:0004122)1.74573926
114Flared iliac wings (HP:0002869)1.74515780
115Abnormality of the distal phalanges of the toes (HP:0010182)1.73819043
116Abnormality of the 2nd finger (HP:0004100)1.72696701
117Disproportionate tall stature (HP:0001519)1.72107282
118Thoracolumbar scoliosis (HP:0002944)1.72075841
119Pulmonary artery stenosis (HP:0004415)1.71523737
120Narrow nasal bridge (HP:0000446)1.71494713
121Aneurysm (HP:0002617)1.71100684
122Broad face (HP:0000283)1.70425683
123Redundant skin (HP:0001582)1.70298406
124Congenital glaucoma (HP:0001087)1.69853015
125Hypoventilation (HP:0002791)1.69663268
126Osteopenia (HP:0000938)1.68818075
127Hypoplastic ischia (HP:0003175)1.67450415
128Thin skin (HP:0000963)1.67426539
129Broad phalanx (HP:0006009)1.67273150
130Thin bony cortex (HP:0002753)1.66565611
131Calcaneovalgus deformity (HP:0001848)1.66289002
132Tarsal synostosis (HP:0008368)1.64854133
133Decreased skull ossification (HP:0004331)1.64319267
134Hip contracture (HP:0003273)1.63940043
135Spondylolisthesis (HP:0003302)1.63259946
136Joint contractures involving the joints of the feet (HP:0100492)1.62409631
137Flexion contracture of toe (HP:0005830)1.62409631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.06070346
2LATS24.45979241
3LATS13.81792393
4SIK13.08319698
5TRIB33.05529235
6EPHB23.04883390
7PDGFRA2.78986350
8TTN2.75347346
9EPHA32.54810423
10NTRK12.22761600
11ERN12.22451139
12PAK22.09704779
13STK382.05357922
14CDK82.01945579
15RPS6KA42.00173770
16LMTK21.98221057
17PKN21.96197669
18TAOK21.92029835
19SIK31.88966339
20MOS1.83785131
21EPHA21.77307588
22TLK11.74860840
23BMX1.64975294
24ERBB31.47925013
25PIK3CA1.42093043
26NEK91.40109668
27STK31.39672413
28DMPK1.38407815
29MYLK1.38249768
30EPHB11.34626042
31ZAK1.31019303
32ROCK11.30029559
33ILK1.29559711
34MKNK11.29019641
35PAK41.28482405
36FGFR11.27580212
37PRPF4B1.27337080
38STK38L1.26231296
39PTK2B1.25726885
40MAP3K31.17831663
41TGFBR21.17519877
42MST1R1.15699424
43NUAK11.14971089
44ERBB41.12314819
45NME21.12302470
46MKNK21.11884369
47GRK71.10378327
48TESK11.07458731
49PTK21.06157810
50GRK51.03600942
51PTK61.01705079
52MAP3K101.00433104
53RPS6KA20.97652010
54MAP2K30.96563265
55PIM20.96510951
56ROCK20.95906956
57ARAF0.94033584
58PAK60.92685299
59LIMK10.91950734
60FER0.91442201
61MAP3K60.89582674
62MAPK70.86783422
63PHKG20.82673075
64PHKG10.82673075
65TRPM70.80620024
66MAP3K70.78347257
67PRKD20.73238196
68PAK10.72281776
69MTOR0.69017738
70TGFBR10.67269888
71PRKG20.66933478
72RIPK10.66624802
73CASK0.63981722
74CLK10.61518923
75MET0.60216051
76ICK0.59946367
77PDGFRB0.59868200
78MAPK150.59478507
79DAPK30.59132877
80MAPKAPK30.58036572
81INSRR0.57377960
82PRKD30.57367265
83CDK70.57163805
84GSK3A0.56394938
85AKT30.56297378
86FGFR20.52885701
87PRKD10.51561967
88PAK30.50752817
89GRK10.50088670
90LRRK20.49707331
91PLK20.49597892
92CAMK1G0.49087151
93CAMK1D0.47393475
94MAPKAPK20.46483441
95MARK30.45940159
96EIF2AK20.45104930
97PRKAA20.44960068
98PRKCH0.44384514
99PLK30.43791951
100HIPK20.42861411
101KIT0.40566583
102AKT10.40276786
103MAP3K20.40027785
104TIE10.39595965
105ADRBK20.38709407
106PIK3CG0.38136821
107ADRBK10.38113269
108INSR0.37757123
109MAPK10.37459210
110SRC0.36784660
111MAP2K10.36250615
112ABL20.35205652
113CDK120.35068729
114PDPK10.34300406
115PRKCE0.34119708
116CHUK0.34114467
117EEF2K0.33848176
118CDC42BPA0.32757910
119PLK40.32288880
120MAPKAPK50.31560643
121CAMK2G0.31547365
122MARK20.31214614
123FRK0.30721137
124RPS6KC10.30340268
125RPS6KL10.30340268
126ATR0.28905710
127RPS6KA60.28823634
128SMG10.28693109
129PASK0.27419049
130CDK90.26265162
131MAP2K60.25781751
132TESK20.25749909
133CAMK10.25502548
134BMPR1B0.23937360
135FLT30.23455985
136CAMK2D0.22953666
137BUB10.22570311
138AKT20.22436397
139CHEK20.21869100
140CAMK40.21796928
141DAPK20.21546536
142SRPK10.21457374
143CDK60.21159586

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.40424977
2Basal cell carcinoma_Homo sapiens_hsa052173.16870348
3Focal adhesion_Homo sapiens_hsa045102.60228541
4Hedgehog signaling pathway_Homo sapiens_hsa043402.48651813
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.41983275
6Proteoglycans in cancer_Homo sapiens_hsa052052.35397180
7Hippo signaling pathway_Homo sapiens_hsa043902.34148586
8TGF-beta signaling pathway_Homo sapiens_hsa043502.32296623
9Protein digestion and absorption_Homo sapiens_hsa049742.23469304
10Adherens junction_Homo sapiens_hsa045202.17086146
11Melanoma_Homo sapiens_hsa052182.12790576
12Bladder cancer_Homo sapiens_hsa052192.03617106
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.00758009
14MicroRNAs in cancer_Homo sapiens_hsa052061.91709517
15Wnt signaling pathway_Homo sapiens_hsa043101.81497293
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.78204013
17Small cell lung cancer_Homo sapiens_hsa052221.75595718
18Amoebiasis_Homo sapiens_hsa051461.74517471
19Chronic myeloid leukemia_Homo sapiens_hsa052201.72143709
20Malaria_Homo sapiens_hsa051441.68571739
21PI3K-Akt signaling pathway_Homo sapiens_hsa041511.65993333
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.63420785
23HTLV-I infection_Homo sapiens_hsa051661.63084756
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61927962
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.60952827
26Prostate cancer_Homo sapiens_hsa052151.54808799
27Axon guidance_Homo sapiens_hsa043601.52661163
28Dilated cardiomyopathy_Homo sapiens_hsa054141.49029142
29Other glycan degradation_Homo sapiens_hsa005111.45530048
30p53 signaling pathway_Homo sapiens_hsa041151.43382451
31Pathways in cancer_Homo sapiens_hsa052001.40592730
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.38057208
33Complement and coagulation cascades_Homo sapiens_hsa046101.33205520
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.32818528
35Cell cycle_Homo sapiens_hsa041101.29952388
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.18545458
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17670238
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12907763
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11650733
40Melanogenesis_Homo sapiens_hsa049161.10046146
41Rap1 signaling pathway_Homo sapiens_hsa040151.08325977
42Endometrial cancer_Homo sapiens_hsa052131.08160528
43Ribosome_Homo sapiens_hsa030101.06641793
44Glioma_Homo sapiens_hsa052141.03239208
45Notch signaling pathway_Homo sapiens_hsa043301.01979665
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01780300
47Colorectal cancer_Homo sapiens_hsa052101.00890201
48Pancreatic cancer_Homo sapiens_hsa052120.99964965
49TNF signaling pathway_Homo sapiens_hsa046680.99587653
50Viral myocarditis_Homo sapiens_hsa054160.95404097
51Sulfur relay system_Homo sapiens_hsa041220.94613672
52One carbon pool by folate_Homo sapiens_hsa006700.93953274
53Hepatitis B_Homo sapiens_hsa051610.92974186
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91816554
55Renin secretion_Homo sapiens_hsa049240.88826861
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88826581
57Salivary secretion_Homo sapiens_hsa049700.86321113
58Thyroid cancer_Homo sapiens_hsa052160.84934029
59Endocytosis_Homo sapiens_hsa041440.83634720
60N-Glycan biosynthesis_Homo sapiens_hsa005100.82295345
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79419295
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78305731
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77367386
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76997888
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75436792
66Selenocompound metabolism_Homo sapiens_hsa004500.75411659
67Tight junction_Homo sapiens_hsa045300.73442389
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.73262060
69Shigellosis_Homo sapiens_hsa051310.72957500
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.72926611
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72094773
72Calcium signaling pathway_Homo sapiens_hsa040200.71898659
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71521562
74Toxoplasmosis_Homo sapiens_hsa051450.70592435
75Viral carcinogenesis_Homo sapiens_hsa052030.69094566
76Sulfur metabolism_Homo sapiens_hsa009200.67561106
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65925742
78Ras signaling pathway_Homo sapiens_hsa040140.65443832
79HIF-1 signaling pathway_Homo sapiens_hsa040660.64039397
80Non-small cell lung cancer_Homo sapiens_hsa052230.63906699
81FoxO signaling pathway_Homo sapiens_hsa040680.63859513
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63603423
83mTOR signaling pathway_Homo sapiens_hsa041500.62906950
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62714314
85Apoptosis_Homo sapiens_hsa042100.62360506
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.61751386
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61511952
88Platelet activation_Homo sapiens_hsa046110.60903962
89Acute myeloid leukemia_Homo sapiens_hsa052210.58229808
90Insulin resistance_Homo sapiens_hsa049310.57955523
91Spliceosome_Homo sapiens_hsa030400.57260068
92Dorso-ventral axis formation_Homo sapiens_hsa043200.55090859
93Lysosome_Homo sapiens_hsa041420.55089661
94Pertussis_Homo sapiens_hsa051330.54291065
95AMPK signaling pathway_Homo sapiens_hsa041520.53879472
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.53293270
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.51812723
98Vibrio cholerae infection_Homo sapiens_hsa051100.51757664
99PPAR signaling pathway_Homo sapiens_hsa033200.51014520
100Leishmaniasis_Homo sapiens_hsa051400.50564103
101Renal cell carcinoma_Homo sapiens_hsa052110.50409832
102GnRH signaling pathway_Homo sapiens_hsa049120.49769495
103VEGF signaling pathway_Homo sapiens_hsa043700.49589920
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49387574
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49222035
106Vitamin B6 metabolism_Homo sapiens_hsa007500.49205916
107Insulin secretion_Homo sapiens_hsa049110.48543301
108Prion diseases_Homo sapiens_hsa050200.48036477
109ErbB signaling pathway_Homo sapiens_hsa040120.47452877
110Ovarian steroidogenesis_Homo sapiens_hsa049130.47369462
111MAPK signaling pathway_Homo sapiens_hsa040100.46877353
112Phagosome_Homo sapiens_hsa041450.46578417
113Fatty acid biosynthesis_Homo sapiens_hsa000610.46317207
114cAMP signaling pathway_Homo sapiens_hsa040240.45852029
115Renin-angiotensin system_Homo sapiens_hsa046140.45318206
116Mineral absorption_Homo sapiens_hsa049780.44935663
117Oxytocin signaling pathway_Homo sapiens_hsa049210.44414930
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44276852
119Salmonella infection_Homo sapiens_hsa051320.44265416
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43787405
121Lysine degradation_Homo sapiens_hsa003100.43620690
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43155346
123Glucagon signaling pathway_Homo sapiens_hsa049220.42497779
124Gap junction_Homo sapiens_hsa045400.40945940
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40555917
126Protein export_Homo sapiens_hsa030600.40479006
127Galactose metabolism_Homo sapiens_hsa000520.40329316
128Circadian rhythm_Homo sapiens_hsa047100.39457727
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.37633605
130Base excision repair_Homo sapiens_hsa034100.37092220
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36807149
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.36262977
133RNA transport_Homo sapiens_hsa030130.35783038
134Homologous recombination_Homo sapiens_hsa034400.35667146
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.35164903
136Measles_Homo sapiens_hsa051620.34993574
137Prolactin signaling pathway_Homo sapiens_hsa049170.34131977
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33410579
139Herpes simplex infection_Homo sapiens_hsa051680.32566428
140Legionellosis_Homo sapiens_hsa051340.31747590
141Estrogen signaling pathway_Homo sapiens_hsa049150.31739752
142Arachidonic acid metabolism_Homo sapiens_hsa005900.31178994

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