OSR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004 [PubMed 15175245]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration involved in heart development (GO:0060973)6.40608398
2protein heterotrimerization (GO:0070208)5.83536386
3type B pancreatic cell proliferation (GO:0044342)5.62150691
4anatomical structure regression (GO:0060033)5.26710768
5endocardial cushion development (GO:0003197)5.11946906
6virion attachment to host cell (GO:0019062)5.05815393
7adhesion of symbiont to host cell (GO:0044650)5.05815393
8planar cell polarity pathway involved in neural tube closure (GO:0090179)4.96772743
9bone trabecula formation (GO:0060346)4.90729477
10regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.67062272
11regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.57212928
12G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.54630269
13adhesion of symbiont to host (GO:0044406)4.37378734
14blood vessel maturation (GO:0001955)4.35301102
15metanephric mesenchyme development (GO:0072075)4.34932907
16positive regulation of endothelial cell apoptotic process (GO:2000353)4.33037935
17fibril organization (GO:0097435)4.14101623
18cell proliferation involved in metanephros development (GO:0072203)4.10890527
19proximal/distal pattern formation (GO:0009954)4.09834597
20mesenchymal-epithelial cell signaling (GO:0060638)4.09569126
21collagen fibril organization (GO:0030199)4.09514676
22glial cell migration (GO:0008347)4.08790755
23outer ear morphogenesis (GO:0042473)4.00837517
24* head development (GO:0060322)3.99275335
25kidney mesenchyme development (GO:0072074)3.97344759
26embryonic cranial skeleton morphogenesis (GO:0048701)3.86778224
27polarized epithelial cell differentiation (GO:0030859)3.85716831
28chondrocyte proliferation (GO:0035988)3.85696357
29keratan sulfate catabolic process (GO:0042340)3.81855754
30regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.75476662
31tooth mineralization (GO:0034505)3.74186705
32regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.72321044
33negative regulation of chondrocyte differentiation (GO:0032331)3.71349710
34hyaluronan catabolic process (GO:0030214)3.69256216
35vascular endothelial growth factor signaling pathway (GO:0038084)3.67699763
36sequestering of extracellular ligand from receptor (GO:0035581)3.63291886
37* embryonic skeletal joint morphogenesis (GO:0060272)3.59645145
38embryo implantation (GO:0007566)3.58635203
39lateral sprouting from an epithelium (GO:0060601)3.58325943
40establishment of apical/basal cell polarity (GO:0035089)3.55921065
41hippo signaling (GO:0035329)3.54420200
42lung-associated mesenchyme development (GO:0060484)3.52016715
43convergent extension (GO:0060026)3.51670253
44regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.50632869
45regulation of organ formation (GO:0003156)3.47032407
46gonadal mesoderm development (GO:0007506)3.45265141
47regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.44935489
48negative regulation of cartilage development (GO:0061037)3.40759391
49collagen metabolic process (GO:0032963)3.40244822
50positive regulation of smoothened signaling pathway (GO:0045880)3.38756234
51mesenchymal cell proliferation (GO:0010463)3.38753298
52negative regulation of catenin import into nucleus (GO:0035414)3.38021159
53regulation of extracellular matrix disassembly (GO:0010715)3.35185651
54paraxial mesoderm development (GO:0048339)3.34569823
55collagen catabolic process (GO:0030574)3.34109614
56multicellular organismal macromolecule metabolic process (GO:0044259)3.33617502
57Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.32426428
58cell proliferation involved in kidney development (GO:0072111)3.31564465
59craniofacial suture morphogenesis (GO:0097094)3.30921504
60multicellular organismal catabolic process (GO:0044243)3.29914564
61regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.28727436
62glomerular basement membrane development (GO:0032836)3.28031276
63* middle ear morphogenesis (GO:0042474)3.27477379
64regulation of establishment of planar polarity (GO:0090175)3.21487286
65anterior/posterior axis specification, embryo (GO:0008595)3.20473501
66negative regulation of smooth muscle cell migration (GO:0014912)3.19286872
67mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.18147809
68multicellular organismal metabolic process (GO:0044236)3.17515854
69peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.16884928
70regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.16361373
71non-canonical Wnt signaling pathway (GO:0035567)3.15928546
72glomerular filtration (GO:0003094)3.14644944
73mesenchyme development (GO:0060485)3.13481648
74* bone morphogenesis (GO:0060349)3.12769774
75renal system development (GO:0072001)3.10342809
76endodermal cell differentiation (GO:0035987)3.09854556
77axon extension involved in axon guidance (GO:0048846)3.08233286
78neuron projection extension involved in neuron projection guidance (GO:1902284)3.08233286
79uterus development (GO:0060065)3.07923950
80renal filtration (GO:0097205)3.07486164
81extracellular matrix assembly (GO:0085029)3.07248051
82growth hormone secretion (GO:0030252)3.07169905
83smooth muscle tissue development (GO:0048745)3.05397715
84pericardium development (GO:0060039)3.03844078
85mesenchymal cell differentiation involved in kidney development (GO:0072161)3.02399541
86mesenchymal cell differentiation involved in renal system development (GO:2001012)3.02399541
87barbed-end actin filament capping (GO:0051016)3.02127286
88mesenchyme morphogenesis (GO:0072132)3.02102034
89cochlea morphogenesis (GO:0090103)3.01743428
90cellular response to vitamin (GO:0071295)3.01103020
91extracellular fibril organization (GO:0043206)3.00460349
92respiratory tube development (GO:0030323)2.99651158
93dermatan sulfate metabolic process (GO:0030205)2.99417452
94branching involved in mammary gland duct morphogenesis (GO:0060444)2.97899897
95urogenital system development (GO:0001655)2.97156305
96body morphogenesis (GO:0010171)2.96952183
97negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.96933749
98positive regulation of mesenchymal cell proliferation (GO:0002053)2.96298917
99positive regulation of male gonad development (GO:2000020)2.94817946
100cellular response to interferon-alpha (GO:0035457)2.93656952
101dermatan sulfate biosynthetic process (GO:0030208)2.93385574
102response to magnesium ion (GO:0032026)2.92802358
103regulation of catenin import into nucleus (GO:0035412)2.91865723
104negative regulation of cell fate specification (GO:0009996)2.91835841
105venous blood vessel morphogenesis (GO:0048845)2.91167642
106establishment of monopolar cell polarity (GO:0061162)2.89528728
107establishment or maintenance of monopolar cell polarity (GO:0061339)2.89528728
108organ induction (GO:0001759)2.89424116
109* hindlimb morphogenesis (GO:0035137)2.88767660
110cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.87510246
111positive regulation of catenin import into nucleus (GO:0035413)2.86663237
112regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.86060278
113* embryonic forelimb morphogenesis (GO:0035115)2.85702218
114negative regulation of axon extension involved in axon guidance (GO:0048843)2.84982056
115regulation of heart morphogenesis (GO:2000826)2.84572759
116extracellular matrix disassembly (GO:0022617)2.83575995
117digestive tract morphogenesis (GO:0048546)2.83146937
118negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.82174389
119basement membrane organization (GO:0071711)2.81709636
120chondrocyte development (GO:0002063)2.80758738
121positive regulation of epithelial to mesenchymal transition (GO:0010718)2.79677053
122extracellular regulation of signal transduction (GO:1900115)2.79620662
123extracellular negative regulation of signal transduction (GO:1900116)2.79620662
124protein retention in ER lumen (GO:0006621)2.78967784
125negative regulation of embryonic development (GO:0045992)2.77474393
126* regulation of gastrulation (GO:0010470)2.77321736
127regulation of metanephros development (GO:0072215)2.77189700
128COPI coating of Golgi vesicle (GO:0048205)2.74841015
129Golgi transport vesicle coating (GO:0048200)2.74841015
130cellular response to amino acid stimulus (GO:0071230)2.74292228
131notochord development (GO:0030903)2.74262885
132* forelimb morphogenesis (GO:0035136)2.73942563
133intestinal epithelial cell development (GO:0060576)2.73082472
134regulation of transforming growth factor beta2 production (GO:0032909)2.72425691
135endothelial cell morphogenesis (GO:0001886)2.69809404
136regulation of cartilage development (GO:0061035)2.69799432
137organ formation (GO:0048645)2.69774102
138positive regulation of cartilage development (GO:0061036)2.69676502
139gastrulation with mouth forming second (GO:0001702)2.69466940
140midgut development (GO:0007494)2.69345166
141extracellular matrix organization (GO:0030198)2.67050897
142negative regulation of fatty acid transport (GO:2000192)2.66929289
143extracellular structure organization (GO:0043062)2.66318716
144regulation of SMAD protein import into nucleus (GO:0060390)2.66171451
145positive regulation of fatty acid beta-oxidation (GO:0032000)2.66106587
146embryonic foregut morphogenesis (GO:0048617)2.65834085
147regulation of integrin-mediated signaling pathway (GO:2001044)2.65807245
148regulation of mesenchymal cell proliferation (GO:0010464)2.65338212
149cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.65164664
150atrioventricular valve morphogenesis (GO:0003181)2.64772004
151positive regulation of SMAD protein import into nucleus (GO:0060391)2.64476069
152skin morphogenesis (GO:0043589)2.64109178
153protein localization to cell surface (GO:0034394)2.63737043
154negative regulation of nitric oxide biosynthetic process (GO:0045019)2.63225356
155muscle cell migration (GO:0014812)2.63224274
156outflow tract septum morphogenesis (GO:0003148)2.63081674
157trabecula formation (GO:0060343)2.62896243
158aorta morphogenesis (GO:0035909)2.62839297
159positive regulation of fibroblast migration (GO:0010763)2.62800285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.67544867
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.41148959
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.75141525
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.82765685
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.81726779
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.81726779
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.81726779
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.52824791
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.50431220
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.36948683
11* EED_16625203_ChIP-ChIP_MESCs_Mouse2.31137774
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.28415306
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27855689
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11267881
15* AR_21909140_ChIP-Seq_LNCAP_Human2.07879261
16CLOCK_20551151_ChIP-Seq_293T_Human2.07111692
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.06118362
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.03115091
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01905356
20ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.98647993
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.97512155
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95924976
23TCF3_18692474_ChIP-Seq_MEFs_Mouse1.95317019
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.90027206
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.86066939
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.83025601
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.79426648
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76430122
29* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.75294646
30RACK7_27058665_Chip-Seq_MCF-7_Human1.74301405
31* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72536782
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.71507797
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70050887
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.68962523
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66890067
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65724336
37CJUN_26792858_Chip-Seq_BT549_Human1.64235628
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.60531357
39ZNF263_19887448_ChIP-Seq_K562_Human1.59006317
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.58849026
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57296668
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55968463
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54007588
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.53321802
45* TP53_20018659_ChIP-ChIP_R1E_Mouse1.51646233
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51127737
47* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.50505288
48HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48911200
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47151488
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47118811
51* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46228345
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.45841784
53* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45132433
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42206584
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.41486397
56* SA1_22415368_ChIP-Seq_MEFs_Mouse1.40488778
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.39921827
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39589553
59* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38500963
60* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38500963
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36863163
62GATA6_25053715_ChIP-Seq_YYC3_Human1.36255361
63SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35661556
64ATF3_27146783_Chip-Seq_COLON_Human1.34969221
65NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.34862360
66* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33168438
67* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32983959
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32878963
69NFIB_24661679_ChIP-Seq_LUNG_Mouse1.32549713
70* LXR_22292898_ChIP-Seq_THP-1_Human1.32109591
71* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.31326389
72* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31113501
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.30389452
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28724835
75ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28381658
76* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28361530
77SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28231716
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27177592
79EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26277680
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25809757
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24372178
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24195595
83TCF3_18692474_ChIP-Seq_MESCs_Mouse1.23635129
84* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.23170211
85MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23160474
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23031607
87TP53_22127205_ChIP-Seq_IMR90_Human1.22822011
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20754668
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.20196307
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19851446
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19797344
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.18527339
93SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17274262
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17274262
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16311961
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15637084
97JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15558042
98RUNX1_27514584_Chip-Seq_MCF-7_Human1.15548405
99P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14330659
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13801507
101* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13793807
102EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13319768
103ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.13098137
104CREB1_26743006_Chip-Seq_LNCaP_Human1.12514261
105MYC_18555785_ChIP-Seq_MESCs_Mouse1.11787560
106SOX2_18692474_ChIP-Seq_MEFs_Mouse1.11688260
107POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11687657
108* NANOG_21062744_ChIP-ChIP_HESCs_Human1.11177179
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09771738
110* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.08926302
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08846849
112NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08808578
113TP53_23651856_ChIP-Seq_MEFs_Mouse1.08266215
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07814527
115BRD4_25478319_ChIP-Seq_HGPS_Human1.07642768
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07308816
117* TBX20_22080862_ChIP-Seq_HEART_Mouse1.06951586
118* TBX20_22328084_ChIP-Seq_HEART_Mouse1.06951586
119* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05767848
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04900229
121NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04900229
122CHD1_26751641_Chip-Seq_LNCaP_Human1.04699502
123RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04607079
124* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04591441
125* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03643177
126AHR_22903824_ChIP-Seq_MCF-7_Human1.03215948
127OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03132942
128UBF1/2_26484160_Chip-Seq_HMECs_Human1.02944744
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02815979
130NANOG_18692474_ChIP-Seq_MEFs_Mouse1.02758446
131SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02508940
132KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02352653
133E2F7_22180533_ChIP-Seq_HELA_Human1.01167861
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00982303
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00193151
136KDM2B_26808549_Chip-Seq_K562_Human0.99998314
137* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99842827
138* RING1B_27294783_Chip-Seq_NPCs_Mouse0.99476983
139* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.98330808
140* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97537601
141MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97411234
142JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97163741
143* GATA4_25053715_ChIP-Seq_YYC3_Human0.96836550
144SOX2_20726797_ChIP-Seq_SW620_Human0.96579323
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96067479
146* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94942393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.03251758
2MP0005503_abnormal_tendon_morphology3.84017828
3MP0010030_abnormal_orbit_morphology3.31588301
4MP0005275_abnormal_skin_tensile3.30590837
5MP0003705_abnormal_hypodermis_morpholog3.20777093
6MP0001542_abnormal_bone_strength3.14905352
7MP0009053_abnormal_anal_canal2.87654985
8MP0000537_abnormal_urethra_morphology2.83679817
9MP0003385_abnormal_body_wall2.46089676
10MP0003123_paternal_imprinting2.35366873
11MP0006054_spinal_hemorrhage2.26928599
12MP0004272_abnormal_basement_membrane2.19033230
13MP0009250_abnormal_appendicular_skeleto2.17178988
14MP0000462_abnormal_digestive_system2.16644991
15MP0001958_emphysema2.16249414
16MP0003942_abnormal_urinary_system2.09956901
17MP0000534_abnormal_ureter_morphology2.09818382
18MP0002295_abnormal_pulmonary_circulatio1.97273725
19MP0002249_abnormal_larynx_morphology1.95320943
20MP0009384_cardiac_valve_regurgitation1.91948884
21* MP0000049_abnormal_middle_ear1.90113929
22MP0005508_abnormal_skeleton_morphology1.86967708
23MP0003941_abnormal_skin_development1.86781677
24MP0003315_abnormal_perineum_morphology1.85081600
25MP0000762_abnormal_tongue_morphology1.82217616
26MP0003122_maternal_imprinting1.82173152
27MP0002060_abnormal_skin_morphology1.71939296
28MP0004264_abnormal_extraembryonic_tissu1.71733775
29MP0000428_abnormal_craniofacial_morphol1.68391537
30MP0003115_abnormal_respiratory_system1.67360254
31MP0002932_abnormal_joint_morphology1.64172188
32MP0010352_gastrointestinal_tract_polyps1.59885524
33* MP0003755_abnormal_palate_morphology1.59133737
34MP0003091_abnormal_cell_migration1.58209328
35MP0003937_abnormal_limbs/digits/tail_de1.53362858
36MP0001348_abnormal_lacrimal_gland1.53241044
37MP0005076_abnormal_cell_differentiation1.47925031
38MP0009780_abnormal_chondrocyte_physiolo1.46860474
39MP0003950_abnormal_plasma_membrane1.46571894
40MP0005390_skeleton_phenotype1.44574141
41MP0003878_abnormal_ear_physiology1.44289056
42MP0005377_hearing/vestibular/ear_phenot1.44289056
43MP0000733_abnormal_muscle_development1.41144634
44MP0004858_abnormal_nervous_system1.38994111
45MP0005367_renal/urinary_system_phenotyp1.37706968
46MP0000516_abnormal_urinary_system1.37706968
47MP0002108_abnormal_muscle_morphology1.36749253
48MP0000751_myopathy1.35799001
49MP0003119_abnormal_digestive_system1.35798528
50MP0003283_abnormal_digestive_organ1.32024007
51* MP0003935_abnormal_craniofacial_develop1.31107667
52MP0001849_ear_inflammation1.30385390
53MP0002254_reproductive_system_inflammat1.28619514
54MP0002282_abnormal_trachea_morphology1.27815154
55* MP0000432_abnormal_head_morphology1.26297677
56MP0002109_abnormal_limb_morphology1.25889066
57MP0001243_abnormal_dermal_layer1.24827487
58MP0002115_abnormal_skeleton_extremities1.24811733
59MP0010368_abnormal_lymphatic_system1.22205789
60MP0005623_abnormal_meninges_morphology1.20441630
61* MP0002116_abnormal_craniofacial_bone1.19999835
62MP0002938_white_spotting1.16570747
63MP0010234_abnormal_vibrissa_follicle1.15326949
64MP0009840_abnormal_foam_cell1.15148564
65MP0000163_abnormal_cartilage_morphology1.14930564
66MP0002896_abnormal_bone_mineralization1.14259230
67MP0004233_abnormal_muscle_weight1.12739132
68MP0005257_abnormal_intraocular_pressure1.11501171
69MP0003567_abnormal_fetal_cardiomyocyte1.11455530
70MP0000538_abnormal_urinary_bladder1.10442273
71MP0005058_abnormal_lysosome_morphology1.10377294
72MP0005360_urolithiasis1.09327025
73MP0002877_abnormal_melanocyte_morpholog1.09305575
74MP0002233_abnormal_nose_morphology1.08574168
75MP0000566_synostosis1.08280874
76MP0003279_aneurysm1.08198486
77MP0005023_abnormal_wound_healing1.07773505
78MP0002111_abnormal_tail_morphology1.07553553
79MP0005248_abnormal_Harderian_gland1.05254874
80MP0009278_abnormal_bone_marrow1.04997017
81MP0002114_abnormal_axial_skeleton1.04343177
82MP0001293_anophthalmia1.02866006
83MP0000613_abnormal_salivary_gland1.01308298
84MP0000579_abnormal_nail_morphology1.00741489
85MP0005595_abnormal_vascular_smooth1.00314864
86MP0002085_abnormal_embryonic_tissue0.99013910
87MP0003121_genomic_imprinting0.97435225
88MP0000678_abnormal_parathyroid_gland0.97086184
89MP0004957_abnormal_blastocyst_morpholog0.96504131
90MP0000681_abnormal_thyroid_gland0.94374880
91MP0004197_abnormal_fetal_growth/weight/0.94237363
92MP0001270_distended_abdomen0.93362976
93MP0010386_abnormal_urinary_bladder0.91579314
94MP0003936_abnormal_reproductive_system0.89944953
95MP0002113_abnormal_skeleton_development0.89839446
96MP0001299_abnormal_eye_distance/0.89344783
97MP0000467_abnormal_esophagus_morphology0.88879112
98MP0002092_abnormal_eye_morphology0.88007187
99MP0005187_abnormal_penis_morphology0.87154322
100MP0000767_abnormal_smooth_muscle0.84840789
101MP0008004_abnormal_stomach_pH0.84100620
102MP0002084_abnormal_developmental_patter0.83219728
103MP0001533_abnormal_skeleton_physiology0.82352362
104MP0005197_abnormal_uvea_morphology0.82227782
105* MP0001340_abnormal_eyelid_morphology0.81329373
106MP0003938_abnormal_ear_development0.80864229
107MP0004134_abnormal_chest_morphology0.80462801
108MP0000477_abnormal_intestine_morphology0.79373600
109MP0000759_abnormal_skeletal_muscle0.78311295
110MP0005164_abnormal_response_to0.77210751
111MP0002086_abnormal_extraembryonic_tissu0.76370656
112MP0002160_abnormal_reproductive_system0.75771583
113MP0003566_abnormal_cell_adhesion0.75151324
114MP0000750_abnormal_muscle_regeneration0.74471162
115MP0000013_abnormal_adipose_tissue0.72890042
116MP0002925_abnormal_cardiovascular_devel0.72050671
117MP0002998_abnormal_bone_remodeling0.69073198
118MP0003795_abnormal_bone_structure0.66922200
119MP0002098_abnormal_vibrissa_morphology0.65892801
120MP0002089_abnormal_postnatal_growth/wei0.65688529
121MP0000003_abnormal_adipose_tissue0.64770724
122MP0003448_altered_tumor_morphology0.64768773
123MP0008995_early_reproductive_senescence0.64212481
124MP0001697_abnormal_embryo_size0.64186313
125MP0003045_fibrosis0.63474424
126MP0003453_abnormal_keratinocyte_physiol0.63451070
127MP0001175_abnormal_lung_morphology0.63424081
128MP0000470_abnormal_stomach_morphology0.63342861
129MP0002128_abnormal_blood_circulation0.60372011
130MP0001664_abnormal_digestion0.60074710
131MP0004510_myositis0.59472582
132MP0002796_impaired_skin_barrier0.57956203
133MP0001614_abnormal_blood_vessel0.57651072
134MP0003186_abnormal_redox_activity0.55570436
135MP0003191_abnormal_cellular_cholesterol0.55557366
136MP0004883_abnormal_blood_vessel0.53851834
137MP0005501_abnormal_skin_physiology0.52771675
138MP0002933_joint_inflammation0.52524378
139MP0002127_abnormal_cardiovascular_syste0.51024785
140MP0010771_integument_phenotype0.50072985
141MP0002135_abnormal_kidney_morphology0.49170035
142MP0005369_muscle_phenotype0.49158755
143MP0002177_abnormal_outer_ear0.48543222

Predicted human phenotypes

RankGene SetZ-score
1Ankle contracture (HP:0006466)5.79242261
2Short 4th metacarpal (HP:0010044)5.09480485
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.09480485
4Protrusio acetabuli (HP:0003179)4.92392193
5Premature rupture of membranes (HP:0001788)4.79430457
6Vascular tortuosity (HP:0004948)4.73526344
7Follicular hyperkeratosis (HP:0007502)4.21934777
8Abnormality of the 4th metacarpal (HP:0010012)4.14807297
9Atrophic scars (HP:0001075)4.03612543
10Shallow orbits (HP:0000586)4.02840760
11Aortic dissection (HP:0002647)3.87483739
12Type 1 muscle fiber predominance (HP:0003803)3.82495481
13Fragile skin (HP:0001030)3.75108164
14Vertebral compression fractures (HP:0002953)3.72343254
15Broad metatarsal (HP:0001783)3.60590352
16Bladder diverticulum (HP:0000015)3.39493781
17Arterial tortuosity (HP:0005116)3.37784139
18Soft skin (HP:0000977)3.26193823
19Slender build (HP:0001533)3.25496385
20Mildly elevated creatine phosphokinase (HP:0008180)3.12380656
21Cerebral aneurysm (HP:0004944)3.07154577
22Spondylolisthesis (HP:0003302)3.06162071
23Biconcave vertebral bodies (HP:0004586)3.03848950
24Aortic aneurysm (HP:0004942)2.94058943
25Increased connective tissue (HP:0009025)2.91147589
26Rectal prolapse (HP:0002035)2.85513642
27Ulnar bowing (HP:0003031)2.80960805
28Renal duplication (HP:0000075)2.79123068
29Abnormality of the parietal bone (HP:0002696)2.73251107
30Mitral valve prolapse (HP:0001634)2.72269234
31Coronal craniosynostosis (HP:0004440)2.64525299
32Aneurysm (HP:0002617)2.59937925
33Spinal rigidity (HP:0003306)2.57832372
34Abnormality of the acetabulum (HP:0003170)2.56806419
35Milia (HP:0001056)2.56601341
36Dilatation of the ascending aorta (HP:0005111)2.55979932
37Emphysema (HP:0002097)2.46348798
38Abnormality of the distal phalanx of the thumb (HP:0009617)2.45827990
39Neonatal short-limb short stature (HP:0008921)2.44737646
40Alopecia of scalp (HP:0002293)2.44221907
41Deviation of the hallux (HP:0010051)2.42600558
42Persistence of primary teeth (HP:0006335)2.39347317
43Microglossia (HP:0000171)2.37851533
44Selective tooth agenesis (HP:0001592)2.37432434
45Mesomelia (HP:0003027)2.37311933
46Wrist flexion contracture (HP:0001239)2.36956111
47Wide anterior fontanel (HP:0000260)2.35536329
48Short phalanx of the thumb (HP:0009660)2.33587375
49Long toe (HP:0010511)2.32350179
50Aortic valve stenosis (HP:0001650)2.31872782
51Abnormal delivery (HP:0001787)2.31713865
52Broad toe (HP:0001837)2.29989719
53Overgrowth (HP:0001548)2.29888591
54Turricephaly (HP:0000262)2.29137717
55Peritonitis (HP:0002586)2.28990718
56Hallux valgus (HP:0001822)2.24198194
57Aplasia of the musculature (HP:0100854)2.23258047
58Natal tooth (HP:0000695)2.22839291
59Increased variability in muscle fiber diameter (HP:0003557)2.21652955
60Nonimmune hydrops fetalis (HP:0001790)2.20977043
61Breech presentation (HP:0001623)2.19861869
62Redundant skin (HP:0001582)2.19114458
63Partial duplication of the phalanx of hand (HP:0009999)2.16466617
64Renovascular hypertension (HP:0100817)2.15776777
65Joint laxity (HP:0001388)2.15181333
66Elbow flexion contracture (HP:0002987)2.14881128
67Delayed cranial suture closure (HP:0000270)2.14261415
68Premature skin wrinkling (HP:0100678)2.12136847
69Blue sclerae (HP:0000592)2.09570430
70Trismus (HP:0000211)2.06746430
71Ankyloglossia (HP:0010296)2.04650461
72Hyperextensible skin (HP:0000974)2.01878854
73Abnormality of proline metabolism (HP:0010907)2.00469370
74Hydroxyprolinuria (HP:0003080)2.00469370
75Abnormality of the phalanges of the hallux (HP:0010057)1.98470862
76Supernumerary ribs (HP:0005815)1.97581622
77Cervical subluxation (HP:0003308)1.96741498
78Genu recurvatum (HP:0002816)1.96543250
79Joint stiffness (HP:0001387)1.95934726
80Thoracolumbar scoliosis (HP:0002944)1.95787657
81Delayed closure of the anterior fontanelle (HP:0001476)1.95783711
82Short 5th finger (HP:0009237)1.95746959
83Protruding ear (HP:0000411)1.95537207
84Abnormal ossification of hand bones (HP:0005921)1.94911822
85Short middle phalanx of the 5th finger (HP:0004220)1.94533479
86Sparse lateral eyebrow (HP:0005338)1.93472560
87Hepatoblastoma (HP:0002884)1.92021607
88Hypoventilation (HP:0002791)1.91756930
89Lymphangioma (HP:0100764)1.89919306
90Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88889478
91Absent frontal sinuses (HP:0002688)1.88806241
92Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.88325484
93Neoplasm of the heart (HP:0100544)1.88151764
94Broad hallux (HP:0010055)1.84074493
95Pulmonary artery stenosis (HP:0004415)1.83777372
96Bowel diverticulosis (HP:0005222)1.83624278
97Shawl scrotum (HP:0000049)1.83551598
98Chin dimple (HP:0010751)1.83470373
99Atresia of the external auditory canal (HP:0000413)1.83386246
100Thin bony cortex (HP:0002753)1.83119860
101Morphological abnormality of the middle ear (HP:0008609)1.82727893
102Deformed tarsal bones (HP:0008119)1.82711895
103Inguinal hernia (HP:0000023)1.82021654
104Abnormality of dentin (HP:0010299)1.81819350
105Abnormality of the distal phalanges of the toes (HP:0010182)1.81675650
106Abnormality of skeletal muscle fiber size (HP:0012084)1.81258560
107Wide cranial sutures (HP:0010537)1.81228556
108Gingival overgrowth (HP:0000212)1.81182738
109Hypoplasia of the iris (HP:0007676)1.79874109
110Wormian bones (HP:0002645)1.79873002
111Abnormality of the 2nd finger (HP:0004100)1.79414115
112Broad long bones (HP:0005622)1.79111468
113Ectopia lentis (HP:0001083)1.78865614
114Abnormality of glutamine family amino acid metabolism (HP:0010902)1.78683229
115Broad thumb (HP:0011304)1.77319628
116Calcaneovalgus deformity (HP:0001848)1.76849059
117Abnormal umbilical cord blood vessels (HP:0011403)1.76357354
118Single umbilical artery (HP:0001195)1.76357354
119Abnormality of the fetal cardiovascular system (HP:0010948)1.76357354
120Tarsal synostosis (HP:0008368)1.76239589
121Narrow nasal bridge (HP:0000446)1.75822782
122Flared iliac wings (HP:0002869)1.75610379
123Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.75352153
124Supernumerary bones of the axial skeleton (HP:0009144)1.74051327
125Osteolytic defects of the hand bones (HP:0009699)1.73670251
126Osteolytic defects of the phalanges of the hand (HP:0009771)1.73670251
127Ovoid vertebral bodies (HP:0003300)1.73623705
128Atelectasis (HP:0100750)1.73078648
129Mitral regurgitation (HP:0001653)1.72661575
130Midline defect of the nose (HP:0004122)1.72484607
131Generalized amyotrophy (HP:0003700)1.72478026
132Malnutrition (HP:0004395)1.72355452
133Disproportionate tall stature (HP:0001519)1.71916770
134Mild short stature (HP:0003502)1.69746396
135Hypoplastic labia majora (HP:0000059)1.69631416
136Abnormality of the peritoneum (HP:0002585)1.69332868
137Dislocated radial head (HP:0003083)1.68504524
138Bowed forearm bones (HP:0003956)1.66524783
139Bowing of the arm (HP:0006488)1.66524783
140Abnormality of the humeroradial joint (HP:0100744)1.65648695
141Abnormality of oral frenula (HP:0000190)1.65440374
142Aortic regurgitation (HP:0001659)1.64968056

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.38508656
2LATS13.65842363
3EPHA33.28247672
4PDGFRA3.19205712
5CDK122.94319464
6EPHB22.73716086
7TRIB32.70903011
8MAP3K102.64124292
9LATS22.41497101
10ICK2.36096722
11RIPK12.22700612
12AKT32.01164222
13CDK71.96336332
14TTN1.94322377
15PTK61.94205444
16TYRO31.86435269
17MST1R1.79579071
18MYLK1.76650011
19STK31.74526719
20MET1.73374895
21NEK91.69587144
22BMX1.68671984
23SIK11.68085138
24PRKCI1.64891023
25GRK51.62511269
26PTK21.58291120
27PAK41.56977717
28PAK21.56245719
29TTK1.52704967
30SMG11.51513073
31ERN11.47211915
32LIMK11.44123753
33ABL21.43323735
34MAPKAPK31.42703204
35EPHA21.40664636
36DMPK1.37876777
37NME21.37163593
38STK38L1.36489853
39GRK71.29353840
40FRK1.27252021
41LMTK21.25975756
42GRK11.25712965
43NEK21.23489192
44MTOR1.21895458
45MAP2K21.21805639
46RPS6KA21.21105026
47RPS6KA41.15159732
48IRAK31.14474158
49MAPK151.14125989
50ARAF1.12355919
51FER1.08317381
52KIT1.08182613
53WEE11.06165125
54FGFR11.05507720
55BUB11.00106353
56GRK60.99697428
57TRPM70.98984634
58DAPK30.98630573
59TAOK20.98291692
60EEF2K0.95690121
61MAPK70.95357328
62PRPF4B0.95138944
63STK380.94608145
64DYRK1B0.93956198
65PAK10.92725287
66ADRBK10.91654694
67ADRBK20.90935802
68NTRK10.90611586
69PKN20.87716651
70NUAK10.87111811
71ERBB20.82950926
72PDGFRB0.82839563
73MOS0.81044293
74LRRK20.79023584
75TBK10.78977389
76PLK10.78879625
77PIK3CG0.78490480
78DYRK30.73400893
79CAMK2G0.73377999
80TESK10.72572654
81JAK10.71436260
82TYK20.69240379
83FGFR20.69236000
84CDC70.68258241
85WNK10.65839475
86TGFBR20.65781499
87AURKB0.65060256
88CLK10.62428692
89MAP2K30.62140802
90GSK3A0.59786278
91MARK20.59438366
92PRKG20.59174471
93CHEK20.58290622
94PRKD20.57838568
95MAP3K80.57763147
96HIPK20.57571723
97CHUK0.57542166
98MAPKAPK20.57338710
99PIM20.56769752
100PRKD10.56475239
101CDK60.55513616
102MATK0.55501260
103MAP3K60.55323047
104PIK3CA0.53930733
105ERBB30.53667125
106PRKD30.52973129
107BRSK10.52801021
108MAP3K110.51670428
109NME10.50656746
110CDK40.50271797
111CDC42BPA0.47986977
112MAP3K120.47789912
113BRAF0.47723928
114MAPK10.46659338
115PTK2B0.46646674
116PDPK10.45647161
117BRSK20.45554439
118PDK20.45421633
119RPS6KB20.44549069
120TESK20.44250186
121RPS6KC10.43664709
122RPS6KL10.43664709
123TGFBR10.42728827
124CDK90.42353678
125TAOK10.41752666
126MELK0.41711959
127FGFR40.40772163
128SIK30.39574398
129CDK80.38024235
130EPHB10.37717859
131ERBB40.36532476
132AURKA0.35319184
133MKNK10.35104850
134RPS6KA10.35086582
135ILK0.35030061
136ROCK10.34785470
137RPS6KA60.33452948
138MAPK40.32753969
139STK100.32173665
140CSNK1E0.31143281
141CDK20.30988065
142MAP3K30.30746700
143ROCK20.30398907
144MAPK30.29070525
145PLK30.29045669
146PLK40.28588949
147WNK40.28559487
148MAP2K10.27315867
149CHEK10.26730765

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.09691537
2Protein digestion and absorption_Homo sapiens_hsa049743.95772375
3Hedgehog signaling pathway_Homo sapiens_hsa043403.78149551
4ECM-receptor interaction_Homo sapiens_hsa045123.27374036
5Renin-angiotensin system_Homo sapiens_hsa046142.98068813
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.95997510
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.81371493
8Hippo signaling pathway_Homo sapiens_hsa043902.68448455
9Other glycan degradation_Homo sapiens_hsa005112.31747937
10TGF-beta signaling pathway_Homo sapiens_hsa043502.14473961
11Focal adhesion_Homo sapiens_hsa045102.06478666
12Adherens junction_Homo sapiens_hsa045201.97890593
13Small cell lung cancer_Homo sapiens_hsa052221.92461334
14Proteoglycans in cancer_Homo sapiens_hsa052051.90451232
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.85577730
16Cell cycle_Homo sapiens_hsa041101.67458338
17Wnt signaling pathway_Homo sapiens_hsa043101.66999728
18Notch signaling pathway_Homo sapiens_hsa043301.63552584
19Fat digestion and absorption_Homo sapiens_hsa049751.63157220
20Amoebiasis_Homo sapiens_hsa051461.55040616
21Mineral absorption_Homo sapiens_hsa049781.51402312
22MicroRNAs in cancer_Homo sapiens_hsa052061.49566202
23Tight junction_Homo sapiens_hsa045301.47934729
24Bladder cancer_Homo sapiens_hsa052191.45951463
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40991959
26Spliceosome_Homo sapiens_hsa030401.39378180
27Sulfur relay system_Homo sapiens_hsa041221.37345404
28Pathways in cancer_Homo sapiens_hsa052001.36512568
29Sulfur metabolism_Homo sapiens_hsa009201.29919666
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28657920
31Lysine degradation_Homo sapiens_hsa003101.28049651
32Glutathione metabolism_Homo sapiens_hsa004801.26461489
33Vitamin B6 metabolism_Homo sapiens_hsa007501.22766096
34p53 signaling pathway_Homo sapiens_hsa041151.22214212
35Lysosome_Homo sapiens_hsa041421.20693190
36Vitamin digestion and absorption_Homo sapiens_hsa049771.19358385
37RNA transport_Homo sapiens_hsa030131.17147466
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16246873
39TNF signaling pathway_Homo sapiens_hsa046681.12117111
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11467530
41Base excision repair_Homo sapiens_hsa034101.07780984
42Prostate cancer_Homo sapiens_hsa052151.06806825
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06464659
44Pentose phosphate pathway_Homo sapiens_hsa000301.06342098
45Arginine and proline metabolism_Homo sapiens_hsa003301.05316698
46HTLV-I infection_Homo sapiens_hsa051661.04529633
47Thyroid cancer_Homo sapiens_hsa052161.04388066
48PI3K-Akt signaling pathway_Homo sapiens_hsa041511.03700164
49Prion diseases_Homo sapiens_hsa050201.01852227
50Chronic myeloid leukemia_Homo sapiens_hsa052201.01350291
51Hepatitis C_Homo sapiens_hsa051601.00756527
52Dilated cardiomyopathy_Homo sapiens_hsa054141.00161243
53Colorectal cancer_Homo sapiens_hsa052100.99788961
54Pertussis_Homo sapiens_hsa051330.96839446
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95995171
56Axon guidance_Homo sapiens_hsa043600.95677640
57Mismatch repair_Homo sapiens_hsa034300.93787439
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92774982
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92005639
60Melanogenesis_Homo sapiens_hsa049160.90306274
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89794949
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85729293
63Acute myeloid leukemia_Homo sapiens_hsa052210.84933885
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83644623
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.79918144
66Ribosome_Homo sapiens_hsa030100.79654872
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78669170
68Fructose and mannose metabolism_Homo sapiens_hsa000510.78647696
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77486468
70Galactose metabolism_Homo sapiens_hsa000520.77361247
71Melanoma_Homo sapiens_hsa052180.77249386
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76069907
73DNA replication_Homo sapiens_hsa030300.74720669
74Insulin resistance_Homo sapiens_hsa049310.74505673
75Endometrial cancer_Homo sapiens_hsa052130.73843334
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.71897869
77mRNA surveillance pathway_Homo sapiens_hsa030150.70926779
78Ovarian steroidogenesis_Homo sapiens_hsa049130.70884064
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70541594
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68586893
81Endocytosis_Homo sapiens_hsa041440.68484151
82mTOR signaling pathway_Homo sapiens_hsa041500.67898409
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.67559971
84Complement and coagulation cascades_Homo sapiens_hsa046100.67425335
85Apoptosis_Homo sapiens_hsa042100.66714401
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66126366
87Pancreatic cancer_Homo sapiens_hsa052120.65818975
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.64666745
89Vibrio cholerae infection_Homo sapiens_hsa051100.64514977
90Sphingolipid metabolism_Homo sapiens_hsa006000.63851032
91Viral carcinogenesis_Homo sapiens_hsa052030.62133176
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61637701
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59822637
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59525653
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58627116
96Toxoplasmosis_Homo sapiens_hsa051450.57572948
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57309202
98Oocyte meiosis_Homo sapiens_hsa041140.57027434
99Prolactin signaling pathway_Homo sapiens_hsa049170.56916217
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55898119
101Viral myocarditis_Homo sapiens_hsa054160.54719639
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.53753983
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.52864743
104Thyroid hormone synthesis_Homo sapiens_hsa049180.52719680
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52478273
106Bile secretion_Homo sapiens_hsa049760.51146757
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49703930
108Histidine metabolism_Homo sapiens_hsa003400.49572232
109Folate biosynthesis_Homo sapiens_hsa007900.49283728
110Renal cell carcinoma_Homo sapiens_hsa052110.47756799
111Osteoclast differentiation_Homo sapiens_hsa043800.47017129
112GnRH signaling pathway_Homo sapiens_hsa049120.46456529
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.46135271
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44369879
115MAPK signaling pathway_Homo sapiens_hsa040100.43852373
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42946396
117Rap1 signaling pathway_Homo sapiens_hsa040150.41520902
118Estrogen signaling pathway_Homo sapiens_hsa049150.41419163
119N-Glycan biosynthesis_Homo sapiens_hsa005100.40776597
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.37221049
121Dorso-ventral axis formation_Homo sapiens_hsa043200.37074992
122Nucleotide excision repair_Homo sapiens_hsa034200.36506317
123Arachidonic acid metabolism_Homo sapiens_hsa005900.35859603
124VEGF signaling pathway_Homo sapiens_hsa043700.33608034
125Herpes simplex infection_Homo sapiens_hsa051680.32118471
126Shigellosis_Homo sapiens_hsa051310.32093811
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31554489
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31306364
129Gap junction_Homo sapiens_hsa045400.30390069
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29539985
131Glioma_Homo sapiens_hsa052140.27802767
132AMPK signaling pathway_Homo sapiens_hsa041520.26773494
133Choline metabolism in cancer_Homo sapiens_hsa052310.25933802
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25812743
135Malaria_Homo sapiens_hsa051440.24512063
136Hepatitis B_Homo sapiens_hsa051610.23973821

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