

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | viral transcription (GO:0019083) | 7.44995959 |
| 2 | ribosomal small subunit biogenesis (GO:0042274) | 7.31987180 |
| 3 | translational termination (GO:0006415) | 7.14221083 |
| 4 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 7.06549667 |
| 5 | ribosomal small subunit assembly (GO:0000028) | 7.04474009 |
| 6 | cotranslational protein targeting to membrane (GO:0006613) | 7.03060744 |
| 7 | protein targeting to ER (GO:0045047) | 6.97568486 |
| 8 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 6.65052530 |
| 9 | protein localization to endoplasmic reticulum (GO:0070972) | 6.62897442 |
| 10 | translational elongation (GO:0006414) | 5.90004634 |
| 11 | sequestering of actin monomers (GO:0042989) | 5.75219902 |
| 12 | viral life cycle (GO:0019058) | 5.64664557 |
| 13 | cellular protein complex disassembly (GO:0043624) | 5.48080064 |
| 14 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.28695581 |
| 15 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 5.12185629 |
| 16 | translational initiation (GO:0006413) | 5.07772158 |
| 17 | maturation of SSU-rRNA (GO:0030490) | 5.04391972 |
| 18 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.93475334 |
| 19 | ATP synthesis coupled proton transport (GO:0015986) | 4.93475334 |
| 20 | translation (GO:0006412) | 4.69665906 |
| 21 | ribosomal large subunit biogenesis (GO:0042273) | 4.68361843 |
| 22 | protein targeting to membrane (GO:0006612) | 4.66682922 |
| 23 | thrombin receptor signaling pathway (GO:0070493) | 4.60320062 |
| 24 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.52744878 |
| 25 | proteasome assembly (GO:0043248) | 4.52203743 |
| 26 | protein complex disassembly (GO:0043241) | 4.51601874 |
| 27 | signal peptide processing (GO:0006465) | 4.47883474 |
| 28 | protein neddylation (GO:0045116) | 4.34015016 |
| 29 | macromolecular complex disassembly (GO:0032984) | 4.25120054 |
| 30 | DNA deamination (GO:0045006) | 4.23004948 |
| 31 | ATP biosynthetic process (GO:0006754) | 4.16326711 |
| 32 | platelet dense granule organization (GO:0060155) | 4.10330786 |
| 33 | respiratory electron transport chain (GO:0022904) | 4.09911274 |
| 34 | GTP biosynthetic process (GO:0006183) | 4.04607166 |
| 35 | electron transport chain (GO:0022900) | 3.99821164 |
| 36 | hydrogen ion transmembrane transport (GO:1902600) | 3.94041284 |
| 37 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.78774263 |
| 38 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.77355355 |
| 39 | termination of RNA polymerase III transcription (GO:0006386) | 3.77005395 |
| 40 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.77005395 |
| 41 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.65503602 |
| 42 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.58014761 |
| 43 | proton transport (GO:0015992) | 3.57519193 |
| 44 | blood coagulation, intrinsic pathway (GO:0007597) | 3.52218773 |
| 45 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.51404848 |
| 46 | NADH dehydrogenase complex assembly (GO:0010257) | 3.51404848 |
| 47 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.51404848 |
| 48 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.51283991 |
| 49 | hydrogen transport (GO:0006818) | 3.50180023 |
| 50 | protein complex biogenesis (GO:0070271) | 3.49057961 |
| 51 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.47719325 |
| 52 | mRNA catabolic process (GO:0006402) | 3.47017107 |
| 53 | UTP biosynthetic process (GO:0006228) | 3.46985581 |
| 54 | inner mitochondrial membrane organization (GO:0007007) | 3.43019271 |
| 55 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.40320850 |
| 56 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.37389974 |
| 57 | negative regulation of appetite (GO:0032099) | 3.35160345 |
| 58 | negative regulation of response to food (GO:0032096) | 3.35160345 |
| 59 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.34336505 |
| 60 | lipoxygenase pathway (GO:0019372) | 3.25719783 |
| 61 | establishment of protein localization to membrane (GO:0090150) | 3.24613930 |
| 62 | autophagic vacuole fusion (GO:0000046) | 3.22057250 |
| 63 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.21931197 |
| 64 | angiogenesis involved in wound healing (GO:0060055) | 3.21036570 |
| 65 | negative regulation of heart rate (GO:0010459) | 3.20039542 |
| 66 | cellular component biogenesis (GO:0044085) | 3.19179814 |
| 67 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.14325578 |
| 68 | peptidyl-histidine modification (GO:0018202) | 3.13480050 |
| 69 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 3.13350523 |
| 70 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.12202832 |
| 71 | protein targeting (GO:0006605) | 3.12024940 |
| 72 | positive regulation of endothelial cell differentiation (GO:0045603) | 3.11404951 |
| 73 | regulation of integrin-mediated signaling pathway (GO:2001044) | 3.10838073 |
| 74 | RNA catabolic process (GO:0006401) | 3.10698360 |
| 75 | mitochondrial calcium ion transport (GO:0006851) | 3.10396233 |
| 76 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.09839552 |
| 77 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.07289902 |
| 78 | chaperone-mediated protein transport (GO:0072321) | 3.05268012 |
| 79 | CTP biosynthetic process (GO:0006241) | 3.03022296 |
| 80 | CTP metabolic process (GO:0046036) | 3.03022296 |
| 81 | negative regulation of hematopoietic progenitor cell differentiation (GO:1901533) | 3.02101978 |
| 82 | UTP metabolic process (GO:0046051) | 3.01583420 |
| 83 | regulation of platelet activation (GO:0010543) | 3.00763676 |
| 84 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.00150909 |
| 85 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.99340161 |
| 86 | negative regulation of ligase activity (GO:0051352) | 2.99340161 |
| 87 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 2.93402701 |
| 88 | L-phenylalanine catabolic process (GO:0006559) | 2.93402701 |
| 89 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.92727620 |
| 90 | positive regulation of mast cell activation (GO:0033005) | 2.92447342 |
| 91 | mitochondrial transport (GO:0006839) | 2.92067190 |
| 92 | regulation of platelet aggregation (GO:0090330) | 2.90826844 |
| 93 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.90735165 |
| 94 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.90735165 |
| 95 | rRNA processing (GO:0006364) | 2.90664212 |
| 96 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 2.89583465 |
| 97 | regulation of lipoprotein metabolic process (GO:0050746) | 2.89453808 |
| 98 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.89401573 |
| 99 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.89401573 |
| 100 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.89401573 |
| 101 | respiratory chain complex IV assembly (GO:0008535) | 2.88664124 |
| 102 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.88551463 |
| 103 | 7-methylguanosine mRNA capping (GO:0006370) | 2.85734400 |
| 104 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.85509653 |
| 105 | oxidative phosphorylation (GO:0006119) | 2.85164912 |
| 106 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.84808096 |
| 107 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.84773044 |
| 108 | 7-methylguanosine RNA capping (GO:0009452) | 2.84322484 |
| 109 | RNA capping (GO:0036260) | 2.84322484 |
| 110 | establishment of protein localization to organelle (GO:0072594) | 2.83140058 |
| 111 | protein targeting to mitochondrion (GO:0006626) | 2.82564181 |
| 112 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.82226373 |
| 113 | negative regulation of norepinephrine secretion (GO:0010700) | 2.80050671 |
| 114 | regulation of oxidative phosphorylation (GO:0002082) | 2.78743780 |
| 115 | polyamine biosynthetic process (GO:0006596) | 2.78273390 |
| 116 | positive regulation of protein homodimerization activity (GO:0090073) | 2.77606022 |
| 117 | rRNA modification (GO:0000154) | 2.77105262 |
| 118 | negative regulation of platelet activation (GO:0010544) | 2.76779227 |
| 119 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.76302819 |
| 120 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.76302819 |
| 121 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.76064530 |
| 122 | pyrimidine nucleotide catabolic process (GO:0006244) | 2.75872757 |
| 123 | rRNA metabolic process (GO:0016072) | 2.75687332 |
| 124 | regulation of metalloenzyme activity (GO:0048552) | 2.74800047 |
| 125 | innate immune response in mucosa (GO:0002227) | 2.74472129 |
| 126 | purine-containing compound salvage (GO:0043101) | 2.72694704 |
| 127 | regulation of mitochondrial translation (GO:0070129) | 2.72677634 |
| 128 | deoxyribonucleotide catabolic process (GO:0009264) | 2.72484445 |
| 129 | G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589) | 2.72030455 |
| 130 | establishment of protein localization to mitochondrion (GO:0072655) | 2.71142226 |
| 131 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.71102126 |
| 132 | platelet aggregation (GO:0070527) | 2.69462304 |
| 133 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.68994207 |
| 134 | establishment of integrated proviral latency (GO:0075713) | 2.68524698 |
| 135 | establishment of viral latency (GO:0019043) | 2.68352175 |
| 136 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.67538791 |
| 137 | leukocyte migration involved in inflammatory response (GO:0002523) | 2.66583159 |
| 138 | dopamine transport (GO:0015872) | 2.65718440 |
| 139 | purinergic nucleotide receptor signaling pathway (GO:0035590) | 2.65163555 |
| 140 | protein localization to mitochondrion (GO:0070585) | 2.64306703 |
| 141 | mannosylation (GO:0097502) | 2.61845115 |
| 142 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.61207316 |
| 143 | response to interferon-beta (GO:0035456) | 2.60858232 |
| 144 | GPI anchor biosynthetic process (GO:0006506) | 2.58955482 |
| 145 | cytochrome complex assembly (GO:0017004) | 2.58413347 |
| 146 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.58346707 |
| 147 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.58210594 |
| 148 | L-methionine salvage (GO:0071267) | 2.56599085 |
| 149 | L-methionine biosynthetic process (GO:0071265) | 2.56599085 |
| 150 | amino acid salvage (GO:0043102) | 2.56599085 |
| 151 | neutrophil activation involved in immune response (GO:0002283) | 2.54785300 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 5.67662743 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.69954249 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.51235659 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.03170791 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.79631813 |
| 6 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.62585440 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.41359422 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.36727725 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.27096754 |
| 10 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.20858266 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.17415743 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.13917389 |
| 13 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.92068114 |
| 14 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.76525500 |
| 15 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.61759825 |
| 16 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.54380788 |
| 17 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.42561167 |
| 18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.41195291 |
| 19 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.40286860 |
| 20 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.33733302 |
| 21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.31065421 |
| 22 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.30942893 |
| 23 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.29166164 |
| 24 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.28905032 |
| 25 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.21260303 |
| 26 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.21172560 |
| 27 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 2.20898021 |
| 28 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.18407087 |
| 29 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 2.10897211 |
| 30 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.04815801 |
| 31 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.97200476 |
| 32 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.89237576 |
| 33 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.87291898 |
| 34 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.83636283 |
| 35 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.81578096 |
| 36 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.78021981 |
| 37 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.77672206 |
| 38 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.77185839 |
| 39 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.76516636 |
| 40 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.71614833 |
| 41 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.70197217 |
| 42 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.69822210 |
| 43 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.66391622 |
| 44 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.62405966 |
| 45 | VDR_22108803_ChIP-Seq_LS180_Human | 1.62397891 |
| 46 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.61644327 |
| 47 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.60365206 |
| 48 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.60216803 |
| 49 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.59440149 |
| 50 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.55627500 |
| 51 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.54313906 |
| 52 | EWS_26573619_Chip-Seq_HEK293_Human | 1.52475492 |
| 53 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.52260400 |
| 54 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.51850239 |
| 55 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.51162595 |
| 56 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.45347373 |
| 57 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.43699637 |
| 58 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.43533772 |
| 59 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.43057393 |
| 60 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.42214610 |
| 61 | AR_20517297_ChIP-Seq_VCAP_Human | 1.41192949 |
| 62 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.38021828 |
| 63 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.37021122 |
| 64 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.36559385 |
| 65 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.33691487 |
| 66 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.30500941 |
| 67 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.29895646 |
| 68 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.28750699 |
| 69 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.27984140 |
| 70 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.27660217 |
| 71 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.22048600 |
| 72 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.19597016 |
| 73 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.19044731 |
| 74 | * NANOG_20526341_ChIP-Seq_ESCs_Human | 1.18751366 |
| 75 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.18224940 |
| 76 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.16368253 |
| 77 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.16090914 |
| 78 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.16090914 |
| 79 | * GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.15802114 |
| 80 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.15337711 |
| 81 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.15337711 |
| 82 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.14916029 |
| 83 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 1.14717160 |
| 84 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.14273046 |
| 85 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.13785390 |
| 86 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.12464493 |
| 87 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.11725234 |
| 88 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.11658432 |
| 89 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.10760948 |
| 90 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.09686196 |
| 91 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.09548319 |
| 92 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08800212 |
| 93 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.06989343 |
| 94 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.06057863 |
| 95 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.05672082 |
| 96 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.03434479 |
| 97 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.01333625 |
| 98 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.01057564 |
| 99 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.00957862 |
| 100 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.00462640 |
| 101 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.00245936 |
| 102 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.97872941 |
| 103 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.95396963 |
| 104 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.93553368 |
| 105 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.92948725 |
| 106 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.92544284 |
| 107 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.91592785 |
| 108 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.90341380 |
| 109 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.88837929 |
| 110 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.87860850 |
| 111 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.87685265 |
| 112 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.87040100 |
| 113 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.86318184 |
| 114 | SOX2_22085726_ChIP-Seq_NPCs_Mouse | 0.86003898 |
| 115 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.85568008 |
| 116 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.85009744 |
| 117 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.82823010 |
| 118 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.82543663 |
| 119 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.82319290 |
| 120 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.82319290 |
| 121 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.82319290 |
| 122 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.81420146 |
| 123 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.80883503 |
| 124 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.79521108 |
| 125 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.78855534 |
| 126 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.78353467 |
| 127 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.78212055 |
| 128 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.77879287 |
| 129 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.77450634 |
| 130 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.77244626 |
| 131 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.75688516 |
| 132 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.74747880 |
| 133 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 0.74593636 |
| 134 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.74311150 |
| 135 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.74036124 |
| 136 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.73415445 |
| 137 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.71365999 |
| 138 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.70010133 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005464_abnormal_platelet_physiology | 6.28950251 |
| 2 | MP0009379_abnormal_foot_pigmentation | 5.68677588 |
| 3 | MP0008004_abnormal_stomach_pH | 4.09585885 |
| 4 | MP0003724_increased_susceptibility_to | 3.35372594 |
| 5 | MP0003186_abnormal_redox_activity | 2.86555899 |
| 6 | MP0003136_yellow_coat_color | 2.64777298 |
| 7 | MP0008438_abnormal_cutaneous_collagen | 2.40946883 |
| 8 | MP0002736_abnormal_nociception_after | 2.37106549 |
| 9 | MP0002148_abnormal_hypersensitivity_rea | 2.20770966 |
| 10 | MP0004381_abnormal_hair_follicle | 2.03304199 |
| 11 | MP0003693_abnormal_embryo_hatching | 2.02788183 |
| 12 | MP0005503_abnormal_tendon_morphology | 1.98464195 |
| 13 | MP0004510_myositis | 1.98251825 |
| 14 | MP0004142_abnormal_muscle_tone | 1.98021236 |
| 15 | MP0002163_abnormal_gland_morphology | 1.96996203 |
| 16 | MP0001542_abnormal_bone_strength | 1.94513395 |
| 17 | MP0002933_joint_inflammation | 1.88151660 |
| 18 | MP0005379_endocrine/exocrine_gland_phen | 1.87973249 |
| 19 | MP0005408_hypopigmentation | 1.87365163 |
| 20 | MP0000372_irregular_coat_pigmentation | 1.86555493 |
| 21 | MP0002938_white_spotting | 1.83186180 |
| 22 | MP0003638_abnormal_response/metabolism_ | 1.82523960 |
| 23 | MP0008872_abnormal_physiological_respon | 1.81249424 |
| 24 | MP0002132_abnormal_respiratory_system | 1.77416853 |
| 25 | MP0009785_altered_susceptibility_to | 1.72956015 |
| 26 | MP0001986_abnormal_taste_sensitivity | 1.69648949 |
| 27 | MP0008932_abnormal_embryonic_tissue | 1.68478783 |
| 28 | MP0001835_abnormal_antigen_presentation | 1.68410271 |
| 29 | MP0004957_abnormal_blastocyst_morpholog | 1.67954130 |
| 30 | MP0009333_abnormal_splenocyte_physiolog | 1.66858483 |
| 31 | MP0003436_decreased_susceptibility_to | 1.62086661 |
| 32 | MP0000230_abnormal_systemic_arterial | 1.61400666 |
| 33 | MP0006054_spinal_hemorrhage | 1.55826594 |
| 34 | MP0005083_abnormal_biliary_tract | 1.55311448 |
| 35 | MP0005000_abnormal_immune_tolerance | 1.54421131 |
| 36 | MP0003941_abnormal_skin_development | 1.48110486 |
| 37 | MP0004084_abnormal_cardiac_muscle | 1.46599507 |
| 38 | MP0005410_abnormal_fertilization | 1.46592655 |
| 39 | MP0005084_abnormal_gallbladder_morpholo | 1.43218311 |
| 40 | MP0005671_abnormal_response_to | 1.40964396 |
| 41 | MP0001533_abnormal_skeleton_physiology | 1.38848786 |
| 42 | MP0005025_abnormal_response_to | 1.38606677 |
| 43 | MP0003011_delayed_dark_adaptation | 1.34424263 |
| 44 | MP0004147_increased_porphyrin_level | 1.31561641 |
| 45 | MP0000343_altered_response_to | 1.29782826 |
| 46 | MP0001968_abnormal_touch/_nociception | 1.29215592 |
| 47 | MP0005646_abnormal_pituitary_gland | 1.28745611 |
| 48 | MP0002419_abnormal_innate_immunity | 1.28108459 |
| 49 | MP0003786_premature_aging | 1.27753004 |
| 50 | MP0006082_CNS_inflammation | 1.26920859 |
| 51 | MP0009250_abnormal_appendicular_skeleto | 1.26726771 |
| 52 | MP0003195_calcinosis | 1.23655814 |
| 53 | MP0008775_abnormal_heart_ventricle | 1.23306523 |
| 54 | MP0005390_skeleton_phenotype | 1.22699342 |
| 55 | MP0005275_abnormal_skin_tensile | 1.22125098 |
| 56 | MP0006292_abnormal_olfactory_placode | 1.17747689 |
| 57 | MP0001663_abnormal_digestive_system | 1.17438556 |
| 58 | MP0009764_decreased_sensitivity_to | 1.17086743 |
| 59 | MP0001853_heart_inflammation | 1.15757015 |
| 60 | MP0006035_abnormal_mitochondrial_morpho | 1.14450501 |
| 61 | MP0002638_abnormal_pupillary_reflex | 1.12418797 |
| 62 | MP0008875_abnormal_xenobiotic_pharmacok | 1.12093647 |
| 63 | MP0002837_dystrophic_cardiac_calcinosis | 1.11032688 |
| 64 | MP0002277_abnormal_respiratory_mucosa | 1.10120655 |
| 65 | MP0005409_darkened_coat_color | 1.09668564 |
| 66 | MP0003718_maternal_effect | 1.08832080 |
| 67 | MP0000685_abnormal_immune_system | 1.08255829 |
| 68 | MP0005365_abnormal_bile_salt | 1.07322737 |
| 69 | MP0002723_abnormal_immune_serum | 1.06046220 |
| 70 | MP0003656_abnormal_erythrocyte_physiolo | 1.06028833 |
| 71 | MP0002405_respiratory_system_inflammati | 1.05890066 |
| 72 | MP0005164_abnormal_response_to | 1.05556591 |
| 73 | MP0000613_abnormal_salivary_gland | 1.05183133 |
| 74 | MP0005085_abnormal_gallbladder_physiolo | 1.03874455 |
| 75 | MP0005075_abnormal_melanosome_morpholog | 1.03536396 |
| 76 | MP0001879_abnormal_lymphatic_vessel | 1.03502047 |
| 77 | MP0003806_abnormal_nucleotide_metabolis | 1.03144642 |
| 78 | MP0002295_abnormal_pulmonary_circulatio | 1.03080673 |
| 79 | MP0005508_abnormal_skeleton_morphology | 1.02225757 |
| 80 | MP0002452_abnormal_antigen_presenting | 1.01990118 |
| 81 | MP0001529_abnormal_vocalization | 1.01346780 |
| 82 | MP0000762_abnormal_tongue_morphology | 1.01068834 |
| 83 | MP0002653_abnormal_ependyma_morphology | 1.01044131 |
| 84 | MP0001790_abnormal_immune_system | 1.00629813 |
| 85 | MP0005387_immune_system_phenotype | 1.00629813 |
| 86 | MP0005636_abnormal_mineral_homeostasis | 0.99241126 |
| 87 | MP0010386_abnormal_urinary_bladder | 0.98615754 |
| 88 | MP0006276_abnormal_autonomic_nervous | 0.98099717 |
| 89 | MP0009763_increased_sensitivity_to | 0.97029998 |
| 90 | MP0008995_early_reproductive_senescence | 0.96977723 |
| 91 | MP0001905_abnormal_dopamine_level | 0.96750680 |
| 92 | MP0000858_altered_metastatic_potential | 0.96567211 |
| 93 | MP0003828_pulmonary_edema | 0.96517102 |
| 94 | MP0004883_abnormal_blood_vessel | 0.96334175 |
| 95 | MP0005171_absent_coat_pigmentation | 0.95838391 |
| 96 | MP0002282_abnormal_trachea_morphology | 0.95741906 |
| 97 | MP0001346_abnormal_lacrimal_gland | 0.94373702 |
| 98 | MP0010329_abnormal_lipoprotein_level | 0.94364050 |
| 99 | MP0003279_aneurysm | 0.93795469 |
| 100 | MP0002234_abnormal_pharynx_morphology | 0.93696167 |
| 101 | MP0001756_abnormal_urination | 0.93633255 |
| 102 | MP0008007_abnormal_cellular_replicative | 0.93119234 |
| 103 | MP0002420_abnormal_adaptive_immunity | 0.91333223 |
| 104 | MP0000049_abnormal_middle_ear | 0.90938369 |
| 105 | MP0001819_abnormal_immune_cell | 0.90608133 |
| 106 | MP0006036_abnormal_mitochondrial_physio | 0.90550704 |
| 107 | MP0002733_abnormal_thermal_nociception | 0.89816586 |
| 108 | MP0004272_abnormal_basement_membrane | 0.89809681 |
| 109 | MP0005167_abnormal_blood-brain_barrier | 0.89162777 |
| 110 | MP0008469_abnormal_protein_level | 0.87757284 |
| 111 | MP0000249_abnormal_blood_vessel | 0.86937803 |
| 112 | MP0002095_abnormal_skin_pigmentation | 0.86322242 |
| 113 | MP0001845_abnormal_inflammatory_respons | 0.84218529 |
| 114 | MP0001800_abnormal_humoral_immune | 0.84054894 |
| 115 | MP0004036_abnormal_muscle_relaxation | 0.83871942 |
| 116 | MP0000163_abnormal_cartilage_morphology | 0.83334823 |
| 117 | MP0001243_abnormal_dermal_layer | 0.82990895 |
| 118 | MP0001727_abnormal_embryo_implantation | 0.82650931 |
| 119 | MP0005645_abnormal_hypothalamus_physiol | 0.81810912 |
| 120 | MP0005058_abnormal_lysosome_morphology | 0.81485203 |
| 121 | MP0005551_abnormal_eye_electrophysiolog | 0.79680726 |
| 122 | MP0003795_abnormal_bone_structure | 0.79572711 |
| 123 | MP0001919_abnormal_reproductive_system | 0.79127696 |
| 124 | MP0005174_abnormal_tail_pigmentation | 0.78621681 |
| 125 | MP0005381_digestive/alimentary_phenotyp | 0.78612799 |
| 126 | MP0002098_abnormal_vibrissa_morphology | 0.78448199 |
| 127 | MP0010155_abnormal_intestine_physiology | 0.77346573 |
| 128 | MP0000490_abnormal_crypts_of | 0.77079389 |
| 129 | MP0009642_abnormal_blood_homeostasis | 0.76946668 |
| 130 | MP0002006_tumorigenesis | 0.76713805 |
| 131 | MP0002102_abnormal_ear_morphology | 0.76498257 |
| 132 | MP0002009_preneoplasia | 0.75463979 |
| 133 | MP0008057_abnormal_DNA_replication | 0.75433328 |
| 134 | MP0001851_eye_inflammation | 0.74976519 |
| 135 | MP0002060_abnormal_skin_morphology | 0.74329741 |
| 136 | MP0000681_abnormal_thyroid_gland | 0.74082892 |
| 137 | MP0000920_abnormal_myelination | 0.73951046 |
| 138 | MP0009697_abnormal_copulation | 0.73390604 |
| 139 | MP0005165_increased_susceptibility_to | 0.72618383 |
| 140 | MP0004134_abnormal_chest_morphology | 0.72522120 |
| 141 | MP0003077_abnormal_cell_cycle | 0.71934331 |
| 142 | MP0001970_abnormal_pain_threshold | 0.71543151 |
| 143 | MP0002398_abnormal_bone_marrow | 0.71349866 |
| 144 | MP0004019_abnormal_vitamin_homeostasis | 0.71008310 |
| 145 | MP0009765_abnormal_xenobiotic_induced | 0.70838487 |
| 146 | MP0000465_gastrointestinal_hemorrhage | 0.69367002 |
| 147 | MP0010030_abnormal_orbit_morphology | 0.68694164 |
| 148 | MP0008789_abnormal_olfactory_epithelium | 0.68549342 |
| 149 | MP0000358_abnormal_cell_content/ | 0.66676823 |
| 150 | MP0001764_abnormal_homeostasis | 0.65957355 |
| 151 | MP0006072_abnormal_retinal_apoptosis | 0.65777138 |
| 152 | MP0001293_anophthalmia | 0.65179959 |
| 153 | MP0004215_abnormal_myocardial_fiber | 0.61508544 |
| 154 | MP0002429_abnormal_blood_cell | 0.60887363 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Prolonged bleeding time (HP:0003010) | 6.19954664 |
| 2 | Menorrhagia (HP:0000132) | 5.89385196 |
| 3 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.47410600 |
| 4 | Increased mean platelet volume (HP:0011877) | 5.37376063 |
| 5 | Abnormal number of erythroid precursors (HP:0012131) | 5.13605856 |
| 6 | Abnormal platelet volume (HP:0011876) | 4.99074809 |
| 7 | Reticulocytopenia (HP:0001896) | 4.97163693 |
| 8 | Acute necrotizing encephalopathy (HP:0006965) | 4.50713011 |
| 9 | Mitochondrial inheritance (HP:0001427) | 4.46146685 |
| 10 | Increased hepatocellular lipid droplets (HP:0006565) | 4.37996681 |
| 11 | Macrocytic anemia (HP:0001972) | 4.15054891 |
| 12 | Epistaxis (HP:0000421) | 4.14157658 |
| 13 | Renal Fanconi syndrome (HP:0001994) | 3.97362581 |
| 14 | Lipid accumulation in hepatocytes (HP:0006561) | 3.92734668 |
| 15 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.88507652 |
| 16 | Gingival bleeding (HP:0000225) | 3.88144820 |
| 17 | Hepatocellular necrosis (HP:0001404) | 3.79512491 |
| 18 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.73381971 |
| 19 | Exertional dyspnea (HP:0002875) | 3.62136701 |
| 20 | Increased CSF lactate (HP:0002490) | 3.56296104 |
| 21 | Hepatic necrosis (HP:0002605) | 3.56237121 |
| 22 | Progressive macrocephaly (HP:0004481) | 3.56010315 |
| 23 | Acute encephalopathy (HP:0006846) | 3.52633206 |
| 24 | Pallor (HP:0000980) | 3.51341044 |
| 25 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.50999084 |
| 26 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.44374026 |
| 27 | 3-Methylglutaconic aciduria (HP:0003535) | 3.40636566 |
| 28 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.39615018 |
| 29 | Impaired platelet aggregation (HP:0003540) | 3.21376949 |
| 30 | Abnormal platelet function (HP:0011869) | 3.21376949 |
| 31 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.20955692 |
| 32 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.20955692 |
| 33 | Hyperlipoproteinemia (HP:0010980) | 3.19408163 |
| 34 | Parakeratosis (HP:0001036) | 3.06350914 |
| 35 | Increased intramyocellular lipid droplets (HP:0012240) | 2.98295063 |
| 36 | Type I transferrin isoform profile (HP:0003642) | 2.84318538 |
| 37 | Congenital, generalized hypertrichosis (HP:0004540) | 2.77952133 |
| 38 | Abnormality of renal resorption (HP:0011038) | 2.75789837 |
| 39 | Abnormal hemoglobin (HP:0011902) | 2.69577325 |
| 40 | Exercise intolerance (HP:0003546) | 2.67131037 |
| 41 | Respiratory failure (HP:0002878) | 2.62292079 |
| 42 | Irregular epiphyses (HP:0010582) | 2.56384632 |
| 43 | Increased muscle lipid content (HP:0009058) | 2.55160828 |
| 44 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.54302214 |
| 45 | Respiratory difficulties (HP:0002880) | 2.50468253 |
| 46 | Poor head control (HP:0002421) | 2.47071698 |
| 47 | Increased serum lactate (HP:0002151) | 2.42223093 |
| 48 | Dyschromatopsia (HP:0007641) | 2.35984834 |
| 49 | Nausea (HP:0002018) | 2.35106195 |
| 50 | Abnormality of urine glucose concentration (HP:0011016) | 2.33235940 |
| 51 | Glycosuria (HP:0003076) | 2.33235940 |
| 52 | Aplastic anemia (HP:0001915) | 2.33164252 |
| 53 | Vacuolated lymphocytes (HP:0001922) | 2.30418590 |
| 54 | Carpal bone hypoplasia (HP:0001498) | 2.29315941 |
| 55 | Hyperphosphaturia (HP:0003109) | 2.28709864 |
| 56 | Optic disc pallor (HP:0000543) | 2.22383714 |
| 57 | 11 pairs of ribs (HP:0000878) | 2.21916571 |
| 58 | Paralysis (HP:0003470) | 2.21753137 |
| 59 | Abnormality of secondary sexual hair (HP:0009888) | 2.21158023 |
| 60 | Abnormality of the axillary hair (HP:0100134) | 2.21158023 |
| 61 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.16628785 |
| 62 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.16628785 |
| 63 | Abnormal protein glycosylation (HP:0012346) | 2.16628785 |
| 64 | Abnormal glycosylation (HP:0012345) | 2.16628785 |
| 65 | Poikilocytosis (HP:0004447) | 2.13788228 |
| 66 | Cerebral edema (HP:0002181) | 2.13107092 |
| 67 | Oral leukoplakia (HP:0002745) | 2.12879212 |
| 68 | Beaking of vertebral bodies (HP:0004568) | 2.10137804 |
| 69 | Lactic acidosis (HP:0003128) | 2.10048953 |
| 70 | Lethargy (HP:0001254) | 2.02883149 |
| 71 | Abnormal pupillary function (HP:0007686) | 2.00970953 |
| 72 | Recurrent abscess formation (HP:0002722) | 2.00446318 |
| 73 | Metaphyseal dysplasia (HP:0100255) | 2.00400598 |
| 74 | Abnormal ciliary motility (HP:0012262) | 2.00056600 |
| 75 | Decreased central vision (HP:0007663) | 1.99423909 |
| 76 | Sparse eyelashes (HP:0000653) | 1.99221838 |
| 77 | Secondary amenorrhea (HP:0000869) | 1.97674843 |
| 78 | Leukodystrophy (HP:0002415) | 1.95647647 |
| 79 | Flat capital femoral epiphysis (HP:0003370) | 1.95402539 |
| 80 | Delayed epiphyseal ossification (HP:0002663) | 1.95010197 |
| 81 | Rough bone trabeculation (HP:0100670) | 1.94969959 |
| 82 | X-linked dominant inheritance (HP:0001423) | 1.92954018 |
| 83 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.92696976 |
| 84 | Spontaneous hematomas (HP:0007420) | 1.92009393 |
| 85 | Epiphyseal dysplasia (HP:0002656) | 1.90452358 |
| 86 | Small epiphyses (HP:0010585) | 1.89249755 |
| 87 | Acanthocytosis (HP:0001927) | 1.86108758 |
| 88 | Patchy hypopigmentation of hair (HP:0011365) | 1.85700357 |
| 89 | Vertebral compression fractures (HP:0002953) | 1.85264557 |
| 90 | Genu varum (HP:0002970) | 1.83966706 |
| 91 | Increased IgM level (HP:0003496) | 1.83693098 |
| 92 | Stomatitis (HP:0010280) | 1.82452394 |
| 93 | Abnormal urine phosphate concentration (HP:0012599) | 1.80413474 |
| 94 | Pancreatic cysts (HP:0001737) | 1.80398340 |
| 95 | Concave nail (HP:0001598) | 1.80256732 |
| 96 | Petechiae (HP:0000967) | 1.79033210 |
| 97 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.78376506 |
| 98 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.78376506 |
| 99 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 1.76457476 |
| 100 | Hepatosplenomegaly (HP:0001433) | 1.76166102 |
| 101 | Breast hypoplasia (HP:0003187) | 1.75992620 |
| 102 | Recurrent bacterial skin infections (HP:0005406) | 1.75342131 |
| 103 | Glossoptosis (HP:0000162) | 1.75151529 |
| 104 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.74901233 |
| 105 | Septo-optic dysplasia (HP:0100842) | 1.74742440 |
| 106 | Reduced antithrombin III activity (HP:0001976) | 1.73296151 |
| 107 | Trismus (HP:0000211) | 1.71983882 |
| 108 | Renal tubular dysfunction (HP:0000124) | 1.71918156 |
| 109 | Tinnitus (HP:0000360) | 1.71913384 |
| 110 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.70687867 |
| 111 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.70320419 |
| 112 | Abnormality of lateral ventricle (HP:0030047) | 1.69614022 |
| 113 | Irregular vertebral endplates (HP:0003301) | 1.69444965 |
| 114 | Partial duplication of thumb phalanx (HP:0009944) | 1.67594754 |
| 115 | Partial duplication of the phalanx of hand (HP:0009999) | 1.67535470 |
| 116 | Generalized aminoaciduria (HP:0002909) | 1.67014182 |
| 117 | Abnormality of midbrain morphology (HP:0002418) | 1.65862178 |
| 118 | Molar tooth sign on MRI (HP:0002419) | 1.65862178 |
| 119 | Microvesicular hepatic steatosis (HP:0001414) | 1.65619853 |
| 120 | Premature rupture of membranes (HP:0001788) | 1.65505748 |
| 121 | Hypothermia (HP:0002045) | 1.65498029 |
| 122 | Pancreatic fibrosis (HP:0100732) | 1.65419286 |
| 123 | Depressed nasal ridge (HP:0000457) | 1.64851924 |
| 124 | Abnormal tarsal ossification (HP:0008369) | 1.63738240 |
| 125 | Muscle fiber atrophy (HP:0100295) | 1.62237979 |
| 126 | Increased serum pyruvate (HP:0003542) | 1.62074341 |
| 127 | Abnormality of glycolysis (HP:0004366) | 1.62074341 |
| 128 | Purpura (HP:0000979) | 1.61612993 |
| 129 | True hermaphroditism (HP:0010459) | 1.61431086 |
| 130 | Abnormal trabecular bone morphology (HP:0100671) | 1.60188538 |
| 131 | Bruising susceptibility (HP:0000978) | 1.59514951 |
| 132 | Type 2 muscle fiber atrophy (HP:0003554) | 1.59357074 |
| 133 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.59023021 |
| 134 | Hypoplasia of the fovea (HP:0007750) | 1.59023021 |
| 135 | Delayed cranial suture closure (HP:0000270) | 1.58360659 |
| 136 | Conjunctival telangiectasia (HP:0000524) | 1.57013660 |
| 137 | Amniotic constriction ring (HP:0009775) | 1.56651219 |
| 138 | Abnormality of placental membranes (HP:0011409) | 1.56651219 |
| 139 | Thrombocytosis (HP:0001894) | 1.56158234 |
| 140 | Adrenal hypoplasia (HP:0000835) | 1.55285449 |
| 141 | Absent/shortened dynein arms (HP:0200106) | 1.54560780 |
| 142 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.54560780 |
| 143 | Degeneration of anterior horn cells (HP:0002398) | 1.54459648 |
| 144 | Abnormality of the anterior horn cell (HP:0006802) | 1.54459648 |
| 145 | Joint swelling (HP:0001386) | 1.53415591 |
| 146 | Pancytopenia (HP:0001876) | 1.51140373 |
| 147 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.49374060 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.12164688 |
| 2 | NME2 | 4.42363787 |
| 3 | STK16 | 3.13968136 |
| 4 | MST4 | 3.12036599 |
| 5 | PBK | 2.94031378 |
| 6 | PIM2 | 2.88993363 |
| 7 | BUB1 | 2.80294815 |
| 8 | EIF2AK1 | 2.77856915 |
| 9 | RIPK4 | 2.61945561 |
| 10 | VRK1 | 2.59756807 |
| 11 | TLK1 | 2.51969247 |
| 12 | EIF2AK3 | 2.31413315 |
| 13 | IRAK3 | 2.27277457 |
| 14 | TESK2 | 1.92624414 |
| 15 | WEE1 | 1.89696614 |
| 16 | BMX | 1.85277885 |
| 17 | NME1 | 1.75024382 |
| 18 | IRAK4 | 1.69870361 |
| 19 | GRK5 | 1.58837894 |
| 20 | BLK | 1.57154072 |
| 21 | TAF1 | 1.55729008 |
| 22 | EPHB2 | 1.54403142 |
| 23 | SRPK1 | 1.52693413 |
| 24 | TEC | 1.52680322 |
| 25 | STK39 | 1.51637625 |
| 26 | KDR | 1.50416216 |
| 27 | PLK4 | 1.47200486 |
| 28 | MYLK | 1.46532734 |
| 29 | MUSK | 1.41920085 |
| 30 | TAOK3 | 1.41873885 |
| 31 | BMPR1B | 1.38625260 |
| 32 | MAPK15 | 1.36402699 |
| 33 | LIMK1 | 1.34025262 |
| 34 | PTK2B | 1.29608974 |
| 35 | ZAK | 1.26331859 |
| 36 | IRAK1 | 1.24188933 |
| 37 | ABL2 | 1.22943090 |
| 38 | MAPKAPK5 | 1.20926213 |
| 39 | TESK1 | 1.20741583 |
| 40 | SYK | 1.20015413 |
| 41 | LRRK2 | 1.07651046 |
| 42 | MAP3K3 | 1.07589507 |
| 43 | PIK3CG | 1.07067855 |
| 44 | NEK9 | 1.03895176 |
| 45 | GRK6 | 1.03316381 |
| 46 | BRSK2 | 1.01192921 |
| 47 | MKNK1 | 0.99106822 |
| 48 | NUAK1 | 0.99000410 |
| 49 | CDK8 | 0.98545279 |
| 50 | RPS6KA5 | 0.98505597 |
| 51 | MKNK2 | 0.95970196 |
| 52 | MAP4K2 | 0.93971000 |
| 53 | CSF1R | 0.93546893 |
| 54 | PNCK | 0.92546813 |
| 55 | IKBKB | 0.91833977 |
| 56 | MAPKAPK3 | 0.91537226 |
| 57 | STK3 | 0.90627633 |
| 58 | WNK4 | 0.90421264 |
| 59 | EIF2AK2 | 0.86223197 |
| 60 | BTK | 0.84257385 |
| 61 | RPS6KA4 | 0.82312367 |
| 62 | PLK3 | 0.82267873 |
| 63 | NLK | 0.81619330 |
| 64 | IRAK2 | 0.80835150 |
| 65 | ADRBK2 | 0.80312361 |
| 66 | TXK | 0.80086026 |
| 67 | DYRK3 | 0.78323088 |
| 68 | MAP2K2 | 0.74652235 |
| 69 | ZAP70 | 0.74514379 |
| 70 | BCR | 0.72972322 |
| 71 | KIT | 0.71133208 |
| 72 | PASK | 0.70937748 |
| 73 | WNK3 | 0.70343101 |
| 74 | OXSR1 | 0.70067236 |
| 75 | PRKG2 | 0.69107045 |
| 76 | PIM1 | 0.68751520 |
| 77 | LYN | 0.67914943 |
| 78 | TRIM28 | 0.67820021 |
| 79 | BCKDK | 0.67611984 |
| 80 | ARAF | 0.66781145 |
| 81 | CSNK2A1 | 0.66470094 |
| 82 | DYRK2 | 0.65293287 |
| 83 | ILK | 0.64879654 |
| 84 | GRK7 | 0.62711957 |
| 85 | RPS6KB2 | 0.62169706 |
| 86 | TBK1 | 0.61967371 |
| 87 | AURKA | 0.60746233 |
| 88 | AURKB | 0.59407475 |
| 89 | DAPK1 | 0.58945644 |
| 90 | CDK19 | 0.58117990 |
| 91 | TYK2 | 0.57982754 |
| 92 | CDK7 | 0.56320269 |
| 93 | ACVR1B | 0.56160965 |
| 94 | MAP3K14 | 0.53256484 |
| 95 | STK4 | 0.53075604 |
| 96 | EPHA2 | 0.52612672 |
| 97 | INSRR | 0.51528166 |
| 98 | CLK1 | 0.50979388 |
| 99 | MATK | 0.50927423 |
| 100 | CSNK2A2 | 0.50786942 |
| 101 | MAP3K11 | 0.49324137 |
| 102 | MAP4K1 | 0.49238376 |
| 103 | MET | 0.49133261 |
| 104 | PLK2 | 0.48485645 |
| 105 | IKBKE | 0.48079859 |
| 106 | ITK | 0.47580091 |
| 107 | HCK | 0.46675225 |
| 108 | MAPK4 | 0.46033978 |
| 109 | PRKCG | 0.45998139 |
| 110 | MAP3K12 | 0.45891289 |
| 111 | GRK1 | 0.45419374 |
| 112 | ADRBK1 | 0.45287815 |
| 113 | BRAF | 0.45028669 |
| 114 | PRKCD | 0.44217430 |
| 115 | YES1 | 0.44214040 |
| 116 | NEK6 | 0.44206832 |
| 117 | DAPK3 | 0.43949396 |
| 118 | BMPR2 | 0.42980284 |
| 119 | TGFBR1 | 0.42551100 |
| 120 | PAK1 | 0.42411329 |
| 121 | TIE1 | 0.41728745 |
| 122 | PKN1 | 0.41688965 |
| 123 | MAPKAPK2 | 0.41331587 |
| 124 | TNK2 | 0.41143001 |
| 125 | FLT3 | 0.40573107 |
| 126 | OBSCN | 0.39965674 |
| 127 | MAP3K5 | 0.39576211 |
| 128 | LCK | 0.39538354 |
| 129 | PLK1 | 0.37353293 |
| 130 | PRKCQ | 0.36587504 |
| 131 | PRKG1 | 0.35722146 |
| 132 | CSNK1G3 | 0.35204962 |
| 133 | TNIK | 0.34566738 |
| 134 | MARK3 | 0.34073661 |
| 135 | STK24 | 0.33922449 |
| 136 | TAOK2 | 0.33253096 |
| 137 | PRKCE | 0.33206946 |
| 138 | PRKCA | 0.33057766 |
| 139 | PRKACA | 0.31329385 |
| 140 | EPHA3 | 0.31293988 |
| 141 | FGR | 0.30988623 |
| 142 | ERBB2 | 0.29391963 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 6.04371863 |
| 2 | Protein export_Homo sapiens_hsa03060 | 4.60798374 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.94999486 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 3.69718039 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.29808076 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 3.16407863 |
| 7 | Huntingtons disease_Homo sapiens_hsa05016 | 2.46568847 |
| 8 | Alzheimers disease_Homo sapiens_hsa05010 | 2.36003900 |
| 9 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.35082919 |
| 10 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.99448772 |
| 11 | DNA replication_Homo sapiens_hsa03030 | 1.89973934 |
| 12 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.84791490 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 1.67450630 |
| 14 | Spliceosome_Homo sapiens_hsa03040 | 1.61188797 |
| 15 | Mismatch repair_Homo sapiens_hsa03430 | 1.56598948 |
| 16 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.55028318 |
| 17 | Platelet activation_Homo sapiens_hsa04611 | 1.50693112 |
| 18 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.45324478 |
| 19 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.44496805 |
| 20 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.43995125 |
| 21 | Basal transcription factors_Homo sapiens_hsa03022 | 1.38183831 |
| 22 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.37361507 |
| 23 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.36525137 |
| 24 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.35066842 |
| 25 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.31696201 |
| 26 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.29465234 |
| 27 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.27638268 |
| 28 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.23411347 |
| 29 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.23119084 |
| 30 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.17166513 |
| 31 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.13533509 |
| 32 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.06411611 |
| 33 | Base excision repair_Homo sapiens_hsa03410 | 1.02350830 |
| 34 | Purine metabolism_Homo sapiens_hsa00230 | 1.02198859 |
| 35 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.00353925 |
| 36 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.00206865 |
| 37 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.97852980 |
| 38 | Malaria_Homo sapiens_hsa05144 | 0.96208763 |
| 39 | Other glycan degradation_Homo sapiens_hsa00511 | 0.95522503 |
| 40 | Asthma_Homo sapiens_hsa05310 | 0.92651965 |
| 41 | RNA degradation_Homo sapiens_hsa03018 | 0.90718664 |
| 42 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.89055691 |
| 43 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.87764292 |
| 44 | Allograft rejection_Homo sapiens_hsa05330 | 0.86842031 |
| 45 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.80917755 |
| 46 | RNA transport_Homo sapiens_hsa03013 | 0.80736517 |
| 47 | Sulfur relay system_Homo sapiens_hsa04122 | 0.80706011 |
| 48 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.79643162 |
| 49 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.77915240 |
| 50 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.77069708 |
| 51 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.74917609 |
| 52 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.73592913 |
| 53 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.73061482 |
| 54 | Phototransduction_Homo sapiens_hsa04744 | 0.70147235 |
| 55 | Metabolic pathways_Homo sapiens_hsa01100 | 0.69585800 |
| 56 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.67938905 |
| 57 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.67405785 |
| 58 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.64444119 |
| 59 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.64142883 |
| 60 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.64025431 |
| 61 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.63675749 |
| 62 | Histidine metabolism_Homo sapiens_hsa00340 | 0.62669615 |
| 63 | Legionellosis_Homo sapiens_hsa05134 | 0.62649484 |
| 64 | Olfactory transduction_Homo sapiens_hsa04740 | 0.62038613 |
| 65 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.59856144 |
| 66 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.59208239 |
| 67 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.57530190 |
| 68 | Phagosome_Homo sapiens_hsa04145 | 0.57269751 |
| 69 | Cell cycle_Homo sapiens_hsa04110 | 0.57054250 |
| 70 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.56741837 |
| 71 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.54878899 |
| 72 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.54561381 |
| 73 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.54131103 |
| 74 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.52800165 |
| 75 | Alcoholism_Homo sapiens_hsa05034 | 0.52638323 |
| 76 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.52367442 |
| 77 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.52071331 |
| 78 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.49177115 |
| 79 | Pertussis_Homo sapiens_hsa05133 | 0.49152869 |
| 80 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.48804234 |
| 81 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.48069024 |
| 82 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.47643760 |
| 83 | Lysosome_Homo sapiens_hsa04142 | 0.46736162 |
| 84 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.46508720 |
| 85 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.45055700 |
| 86 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.44850052 |
| 87 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.43735807 |
| 88 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.43252326 |
| 89 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.42406980 |
| 90 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.41982911 |
| 91 | Retinol metabolism_Homo sapiens_hsa00830 | 0.41965226 |
| 92 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.39440754 |
| 93 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.39258534 |
| 94 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.38772278 |
| 95 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.37398744 |
| 96 | Leishmaniasis_Homo sapiens_hsa05140 | 0.37292501 |
| 97 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.36476056 |
| 98 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.35285077 |
| 99 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.34863890 |
| 100 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.33739110 |
| 101 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.32009440 |
| 102 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.31248085 |
| 103 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.30596699 |
| 104 | Measles_Homo sapiens_hsa05162 | 0.30182296 |
| 105 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.29857447 |
| 106 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.29472358 |
| 107 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.29459670 |
| 108 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.28703339 |
| 109 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.27402880 |
| 110 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.27073821 |
| 111 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.26417335 |
| 112 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.25997394 |
| 113 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.25427216 |
| 114 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.23644332 |
| 115 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.23140108 |
| 116 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.22921752 |
| 117 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.22874062 |
| 118 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.21746008 |
| 119 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.21617747 |
| 120 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.20699443 |
| 121 | Galactose metabolism_Homo sapiens_hsa00052 | 0.20322634 |
| 122 | Peroxisome_Homo sapiens_hsa04146 | 0.20062534 |
| 123 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.19547575 |
| 124 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.19366014 |
| 125 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.19210531 |
| 126 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.18697968 |
| 127 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.16023713 |
| 128 | Shigellosis_Homo sapiens_hsa05131 | 0.15621546 |

