

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Golgi transport vesicle coating (GO:0048200) | 9.40123926 |
| 2 | COPI coating of Golgi vesicle (GO:0048205) | 9.40123926 |
| 3 | signal peptide processing (GO:0006465) | 7.72334616 |
| 4 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 6.52512738 |
| 5 | protein retention in ER lumen (GO:0006621) | 5.76003353 |
| 6 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.57065987 |
| 7 | protein maturation by protein folding (GO:0022417) | 5.17428532 |
| 8 | COPII vesicle coating (GO:0048208) | 5.01816016 |
| 9 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.94690761 |
| 10 | cotranslational protein targeting to membrane (GO:0006613) | 4.84779315 |
| 11 | protein targeting to ER (GO:0045047) | 4.82896765 |
| 12 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.74218993 |
| 13 | ATP synthesis coupled proton transport (GO:0015986) | 4.74218993 |
| 14 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.73406986 |
| 15 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 4.71263625 |
| 16 | protein localization to endoplasmic reticulum (GO:0070972) | 4.59080932 |
| 17 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.57569140 |
| 18 | DNA deamination (GO:0045006) | 4.43486947 |
| 19 | CENP-A containing nucleosome assembly (GO:0034080) | 4.40819393 |
| 20 | chromatin remodeling at centromere (GO:0031055) | 4.36812431 |
| 21 | ribosomal small subunit assembly (GO:0000028) | 4.29505031 |
| 22 | chaperone-mediated protein transport (GO:0072321) | 4.29262230 |
| 23 | GDP-mannose metabolic process (GO:0019673) | 4.25397358 |
| 24 | protein neddylation (GO:0045116) | 4.18458713 |
| 25 | sequestering of metal ion (GO:0051238) | 4.10639910 |
| 26 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.93548124 |
| 27 | cullin deneddylation (GO:0010388) | 3.76518952 |
| 28 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.72026514 |
| 29 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.69393384 |
| 30 | DNA double-strand break processing (GO:0000729) | 3.66083657 |
| 31 | activation of signaling protein activity involved in unfolded protein response (GO:0006987) | 3.64778434 |
| 32 | histone exchange (GO:0043486) | 3.64567099 |
| 33 | respiratory electron transport chain (GO:0022904) | 3.64496679 |
| 34 | proteasome assembly (GO:0043248) | 3.63999908 |
| 35 | positive regulation of nuclease activity (GO:0032075) | 3.62921303 |
| 36 | protein deneddylation (GO:0000338) | 3.60662801 |
| 37 | formation of translation preinitiation complex (GO:0001731) | 3.59924891 |
| 38 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.59338824 |
| 39 | endocrine pancreas development (GO:0031018) | 3.57174396 |
| 40 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.56484949 |
| 41 | termination of RNA polymerase III transcription (GO:0006386) | 3.56484949 |
| 42 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.56297691 |
| 43 | electron transport chain (GO:0022900) | 3.55921858 |
| 44 | protein complex biogenesis (GO:0070271) | 3.51439328 |
| 45 | ER overload response (GO:0006983) | 3.50949989 |
| 46 | translation (GO:0006412) | 3.50406205 |
| 47 | nucleotide-sugar biosynthetic process (GO:0009226) | 3.48364291 |
| 48 | vesicle coating (GO:0006901) | 3.47983741 |
| 49 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.47978136 |
| 50 | ribosome assembly (GO:0042255) | 3.47851022 |
| 51 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.44878704 |
| 52 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.44321623 |
| 53 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.42538413 |
| 54 | positive regulation of ligase activity (GO:0051351) | 3.40232789 |
| 55 | regulation of nuclease activity (GO:0032069) | 3.37875950 |
| 56 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 3.36500016 |
| 57 | peptide hormone processing (GO:0016486) | 3.36224461 |
| 58 | * protein N-linked glycosylation via asparagine (GO:0018279) | 3.36059369 |
| 59 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.34516144 |
| 60 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.34516144 |
| 61 | NADH dehydrogenase complex assembly (GO:0010257) | 3.34516144 |
| 62 | DNA replication checkpoint (GO:0000076) | 3.33925015 |
| 63 | rRNA modification (GO:0000154) | 3.30917176 |
| 64 | * peptidyl-asparagine modification (GO:0018196) | 3.30076811 |
| 65 | mitotic metaphase plate congression (GO:0007080) | 3.29655557 |
| 66 | exocrine pancreas development (GO:0031017) | 3.28084018 |
| 67 | endoplasmic reticulum unfolded protein response (GO:0030968) | 3.27669188 |
| 68 | peptidyl-histidine modification (GO:0018202) | 3.27181122 |
| 69 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 3.27113031 |
| 70 | protein peptidyl-prolyl isomerization (GO:0000413) | 3.26241451 |
| 71 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.25014879 |
| 72 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.25014879 |
| 73 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.24275435 |
| 74 | histone mRNA metabolic process (GO:0008334) | 3.23874242 |
| 75 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.22634320 |
| 76 | DNA replication-independent nucleosome organization (GO:0034724) | 3.22410352 |
| 77 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.22410352 |
| 78 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.22103426 |
| 79 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.22103426 |
| 80 | regulation of type B pancreatic cell apoptotic process (GO:2000674) | 3.21744981 |
| 81 | cellular response to unfolded protein (GO:0034620) | 3.21452782 |
| 82 | ER to Golgi vesicle-mediated transport (GO:0006888) | 3.19453445 |
| 83 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.19446371 |
| 84 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.19446371 |
| 85 | * protein N-linked glycosylation (GO:0006487) | 3.18660457 |
| 86 | viral transcription (GO:0019083) | 3.17921341 |
| 87 | cellular response to topologically incorrect protein (GO:0035967) | 3.17859804 |
| 88 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.17632710 |
| 89 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.17227658 |
| 90 | translational termination (GO:0006415) | 3.16947537 |
| 91 | protein targeting to membrane (GO:0006612) | 3.16029760 |
| 92 | proline biosynthetic process (GO:0006561) | 3.15951326 |
| 93 | establishment of viral latency (GO:0019043) | 3.15461019 |
| 94 | cytochrome complex assembly (GO:0017004) | 3.14647963 |
| 95 | UDP-N-acetylglucosamine metabolic process (GO:0006047) | 3.14028635 |
| 96 | ER-associated ubiquitin-dependent protein catabolic process (GO:0030433) | 3.13158285 |
| 97 | spliceosomal snRNP assembly (GO:0000387) | 3.12884514 |
| 98 | regulation of ligase activity (GO:0051340) | 3.10544700 |
| 99 | DNA ligation (GO:0006266) | 3.09766629 |
| 100 | oxidative phosphorylation (GO:0006119) | 3.09743935 |
| 101 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.05698961 |
| 102 | chaperone-mediated protein folding (GO:0061077) | 3.03989559 |
| 103 | regulation of protein heterodimerization activity (GO:0043497) | 3.03764299 |
| 104 | metaphase plate congression (GO:0051310) | 3.03411607 |
| 105 | protein targeting to mitochondrion (GO:0006626) | 3.02913229 |
| 106 | glandular epithelial cell differentiation (GO:0002067) | 3.00843179 |
| 107 | peptidyl-proline modification (GO:0018208) | 3.00396892 |
| 108 | ribosomal small subunit biogenesis (GO:0042274) | 3.00149992 |
| 109 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.99143763 |
| 110 | IMP biosynthetic process (GO:0006188) | 2.98561383 |
| 111 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.96789817 |
| 112 | ER-nucleus signaling pathway (GO:0006984) | 2.96299268 |
| 113 | inner mitochondrial membrane organization (GO:0007007) | 2.93474649 |
| 114 | aldehyde catabolic process (GO:0046185) | 2.92342894 |
| 115 | translational elongation (GO:0006414) | 2.91810168 |
| 116 | DNA damage response, detection of DNA damage (GO:0042769) | 2.90877223 |
| 117 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.89864703 |
| 118 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.88558233 |
| 119 | negative regulation of ligase activity (GO:0051352) | 2.88208772 |
| 120 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.88208772 |
| 121 | pseudouridine synthesis (GO:0001522) | 2.86632863 |
| 122 | maturation of 5.8S rRNA (GO:0000460) | 2.86572870 |
| 123 | negative regulation of protein ubiquitination (GO:0031397) | 2.86197712 |
| 124 | kinetochore organization (GO:0051383) | 2.84655980 |
| 125 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.84522716 |
| 126 | kinetochore assembly (GO:0051382) | 2.83915584 |
| 127 | nucleobase biosynthetic process (GO:0046112) | 2.83861791 |
| 128 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.83774174 |
| 129 | cell cycle G1/S phase transition (GO:0044843) | 2.83774174 |
| 130 | nucleotide transmembrane transport (GO:1901679) | 2.82719665 |
| 131 | protein localization to mitochondrion (GO:0070585) | 2.82148189 |
| 132 | cell redox homeostasis (GO:0045454) | 2.82138222 |
| 133 | rRNA methylation (GO:0031167) | 2.82119308 |
| 134 | regulation of cellular amine metabolic process (GO:0033238) | 2.81345494 |
| 135 | regulation of mitochondrial translation (GO:0070129) | 2.79744269 |
| 136 | positive regulation of cell cycle arrest (GO:0071158) | 2.79566427 |
| 137 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.79383903 |
| 138 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.79383903 |
| 139 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.79292424 |
| 140 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.78789524 |
| 141 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.78789524 |
| 142 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.78789524 |
| 143 | establishment of protein localization to mitochondrion (GO:0072655) | 2.78296731 |
| 144 | translational initiation (GO:0006413) | 2.78293164 |
| 145 | nucleotide-sugar metabolic process (GO:0009225) | 2.77930171 |
| 146 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.76879728 |
| 147 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.76397761 |
| 148 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.75979301 |
| 149 | ribosomal large subunit biogenesis (GO:0042273) | 2.74979381 |
| 150 | purine nucleobase biosynthetic process (GO:0009113) | 2.73461661 |
| 151 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235 | 2.71100772 |
| 152 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.71033746 |
| 153 | response to endoplasmic reticulum stress (GO:0034976) | 2.70815200 |
| 154 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.69681177 |
| 155 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.69192180 |
| 156 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.69192180 |
| 157 | viral life cycle (GO:0019058) | 2.67818868 |
| 158 | 7-methylguanosine mRNA capping (GO:0006370) | 2.66844390 |
| 159 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.65201957 |
| 160 | respiratory chain complex IV assembly (GO:0008535) | 2.64642179 |
| 161 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.62658424 |
| 162 | 7-methylguanosine RNA capping (GO:0009452) | 2.59497002 |
| 163 | RNA capping (GO:0036260) | 2.59497002 |
| 164 | establishment of integrated proviral latency (GO:0075713) | 2.58394165 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.79470558 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.41909611 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.83207732 |
| 4 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 3.69595925 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.68428477 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.68056496 |
| 7 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.64717456 |
| 8 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.63953149 |
| 9 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.58856662 |
| 10 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.53722203 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.30110839 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.17919742 |
| 13 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.87459822 |
| 14 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.74779557 |
| 15 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.72660934 |
| 16 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.56978135 |
| 17 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.56800467 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.50495640 |
| 19 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.45464319 |
| 20 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.43030301 |
| 21 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.41894101 |
| 22 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.36869033 |
| 23 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.27269202 |
| 24 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.25553979 |
| 25 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.23619813 |
| 26 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.22619003 |
| 27 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.18173917 |
| 28 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.17326017 |
| 29 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.17120170 |
| 30 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 2.16566454 |
| 31 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 2.13414591 |
| 32 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.12160436 |
| 33 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.10321077 |
| 34 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.10010496 |
| 35 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.09196254 |
| 36 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.94700305 |
| 37 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.92407089 |
| 38 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.90252281 |
| 39 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.84350810 |
| 40 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.82579077 |
| 41 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.81740612 |
| 42 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.81613710 |
| 43 | EWS_26573619_Chip-Seq_HEK293_Human | 1.78422689 |
| 44 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.76115199 |
| 45 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.75799670 |
| 46 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.75500525 |
| 47 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.70640406 |
| 48 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.70511852 |
| 49 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.68463772 |
| 50 | FUS_26573619_Chip-Seq_HEK293_Human | 1.67033729 |
| 51 | VDR_22108803_ChIP-Seq_LS180_Human | 1.65011045 |
| 52 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.59650355 |
| 53 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.56305599 |
| 54 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.55942805 |
| 55 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.55731381 |
| 56 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.52413790 |
| 57 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.50757960 |
| 58 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.48596398 |
| 59 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.45677360 |
| 60 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.45321009 |
| 61 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.43329585 |
| 62 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.43001193 |
| 63 | GATA1_22025678_ChIP-Seq_K562_Human | 1.41312713 |
| 64 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.40268281 |
| 65 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.37869535 |
| 66 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.36245193 |
| 67 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.34940054 |
| 68 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.33887002 |
| 69 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.33023457 |
| 70 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.32491524 |
| 71 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.28106317 |
| 72 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.27808121 |
| 73 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.25515988 |
| 74 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.24311954 |
| 75 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.23030900 |
| 76 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.21870523 |
| 77 | P300_19829295_ChIP-Seq_ESCs_Human | 1.20161414 |
| 78 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.18633447 |
| 79 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.18374894 |
| 80 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.18214284 |
| 81 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.16786630 |
| 82 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.16679995 |
| 83 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.16087924 |
| 84 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.14686713 |
| 85 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.14093386 |
| 86 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.12803904 |
| 87 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.12389997 |
| 88 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.11561320 |
| 89 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.08743615 |
| 90 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.08592370 |
| 91 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.08099988 |
| 92 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.06575013 |
| 93 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.03158131 |
| 94 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.03123701 |
| 95 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.02126253 |
| 96 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.01830793 |
| 97 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.01518608 |
| 98 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.00668675 |
| 99 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.98296781 |
| 100 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.98248334 |
| 101 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.98071933 |
| 102 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.96406471 |
| 103 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.95764482 |
| 104 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.95269304 |
| 105 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.95082708 |
| 106 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.92993585 |
| 107 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.92085071 |
| 108 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.91522913 |
| 109 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.91239657 |
| 110 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 0.88280500 |
| 111 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.87901309 |
| 112 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.87901309 |
| 113 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.86041873 |
| 114 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.85781171 |
| 115 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.84452715 |
| 116 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.83835220 |
| 117 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.82449767 |
| 118 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.81442718 |
| 119 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.80928917 |
| 120 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.78386014 |
| 121 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.78122364 |
| 122 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.78096013 |
| 123 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.77744541 |
| 124 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.77666889 |
| 125 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.76665921 |
| 126 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.76305557 |
| 127 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.76207978 |
| 128 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.75828093 |
| 129 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.75676364 |
| 130 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.75557953 |
| 131 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.75552064 |
| 132 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.75309658 |
| 133 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.75137057 |
| 134 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.72993403 |
| 135 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.72389104 |
| 136 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.72234078 |
| 137 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.70561836 |
| 138 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.69894131 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 3.76697500 |
| 2 | MP0006054_spinal_hemorrhage | 3.21474847 |
| 3 | MP0003941_abnormal_skin_development | 3.20461302 |
| 4 | MP0002877_abnormal_melanocyte_morpholog | 3.01238564 |
| 5 | MP0005220_abnormal_exocrine_pancreas | 2.92428889 |
| 6 | MP0003195_calcinosis | 2.63169020 |
| 7 | MP0008438_abnormal_cutaneous_collagen | 2.60303561 |
| 8 | MP0002693_abnormal_pancreas_physiology | 2.59904858 |
| 9 | MP0004957_abnormal_blastocyst_morpholog | 2.58409322 |
| 10 | MP0001944_abnormal_pancreas_morphology | 2.50270292 |
| 11 | MP0010030_abnormal_orbit_morphology | 2.39589702 |
| 12 | MP0003283_abnormal_digestive_organ | 2.27738811 |
| 13 | MP0005379_endocrine/exocrine_gland_phen | 2.26045195 |
| 14 | MP0000013_abnormal_adipose_tissue | 2.23929456 |
| 15 | MP0010386_abnormal_urinary_bladder | 2.21417466 |
| 16 | MP0004043_abnormal_pH_regulation | 2.16837833 |
| 17 | MP0005503_abnormal_tendon_morphology | 2.15289398 |
| 18 | MP0005408_hypopigmentation | 2.10187323 |
| 19 | MP0003806_abnormal_nucleotide_metabolis | 2.05625040 |
| 20 | MP0002102_abnormal_ear_morphology | 2.04543316 |
| 21 | MP0000678_abnormal_parathyroid_gland | 2.03428761 |
| 22 | MP0003183_abnormal_peptide_metabolism | 1.95552269 |
| 23 | MP0002933_joint_inflammation | 1.92805189 |
| 24 | MP0003123_paternal_imprinting | 1.92600991 |
| 25 | MP0001293_anophthalmia | 1.92187307 |
| 26 | MP0003186_abnormal_redox_activity | 1.77943812 |
| 27 | MP0000372_irregular_coat_pigmentation | 1.76955236 |
| 28 | MP0006292_abnormal_olfactory_placode | 1.73780435 |
| 29 | MP0008057_abnormal_DNA_replication | 1.67586170 |
| 30 | MP0003567_abnormal_fetal_cardiomyocyte | 1.65759699 |
| 31 | MP0001529_abnormal_vocalization | 1.63036707 |
| 32 | MP0005084_abnormal_gallbladder_morpholo | 1.62150871 |
| 33 | MP0001542_abnormal_bone_strength | 1.61365036 |
| 34 | MP0003122_maternal_imprinting | 1.58839435 |
| 35 | MP0009333_abnormal_splenocyte_physiolog | 1.57853043 |
| 36 | MP0003937_abnormal_limbs/digits/tail_de | 1.57546841 |
| 37 | MP0004147_increased_porphyrin_level | 1.54655280 |
| 38 | MP0002896_abnormal_bone_mineralization | 1.51025865 |
| 39 | MP0008932_abnormal_embryonic_tissue | 1.49270089 |
| 40 | MP0002909_abnormal_adrenal_gland | 1.46107872 |
| 41 | MP0003950_abnormal_plasma_membrane | 1.44972181 |
| 42 | MP0002254_reproductive_system_inflammat | 1.44640178 |
| 43 | MP0009780_abnormal_chondrocyte_physiolo | 1.42150656 |
| 44 | MP0008877_abnormal_DNA_methylation | 1.42060540 |
| 45 | MP0009379_abnormal_foot_pigmentation | 1.40838424 |
| 46 | MP0009697_abnormal_copulation | 1.40023985 |
| 47 | MP0003136_yellow_coat_color | 1.36686237 |
| 48 | MP0004264_abnormal_extraembryonic_tissu | 1.36670449 |
| 49 | MP0008007_abnormal_cellular_replicative | 1.32098271 |
| 50 | MP0000516_abnormal_urinary_system | 1.31047517 |
| 51 | MP0005367_renal/urinary_system_phenotyp | 1.31047517 |
| 52 | MP0002090_abnormal_vision | 1.30305080 |
| 53 | MP0002163_abnormal_gland_morphology | 1.29696893 |
| 54 | MP0004133_heterotaxia | 1.28867428 |
| 55 | MP0008789_abnormal_olfactory_epithelium | 1.27624184 |
| 56 | MP0002233_abnormal_nose_morphology | 1.26885607 |
| 57 | MP0003011_delayed_dark_adaptation | 1.26433662 |
| 58 | MP0003795_abnormal_bone_structure | 1.25864070 |
| 59 | MP0003077_abnormal_cell_cycle | 1.24592135 |
| 60 | MP0000163_abnormal_cartilage_morphology | 1.24191982 |
| 61 | MP0008058_abnormal_DNA_repair | 1.22396736 |
| 62 | MP0002938_white_spotting | 1.22268189 |
| 63 | MP0005257_abnormal_intraocular_pressure | 1.20821945 |
| 64 | MP0006035_abnormal_mitochondrial_morpho | 1.14735514 |
| 65 | MP0004782_abnormal_surfactant_physiolog | 1.14232921 |
| 66 | MP0001986_abnormal_taste_sensitivity | 1.11914928 |
| 67 | MP0001286_abnormal_eye_development | 1.11645564 |
| 68 | MP0009643_abnormal_urine_homeostasis | 1.10943525 |
| 69 | MP0000613_abnormal_salivary_gland | 1.10577552 |
| 70 | MP0001348_abnormal_lacrimal_gland | 1.09652760 |
| 71 | MP0001697_abnormal_embryo_size | 1.09380072 |
| 72 | MP0005636_abnormal_mineral_homeostasis | 1.09147008 |
| 73 | MP0006072_abnormal_retinal_apoptosis | 1.09087476 |
| 74 | MP0008995_early_reproductive_senescence | 1.08428568 |
| 75 | MP0002084_abnormal_developmental_patter | 1.08191361 |
| 76 | MP0005275_abnormal_skin_tensile | 1.07541199 |
| 77 | MP0001533_abnormal_skeleton_physiology | 1.05401706 |
| 78 | MP0002078_abnormal_glucose_homeostasis | 1.04570804 |
| 79 | MP0005360_urolithiasis | 1.03776658 |
| 80 | MP0005253_abnormal_eye_physiology | 1.03415275 |
| 81 | MP0000490_abnormal_crypts_of | 1.03347368 |
| 82 | MP0002638_abnormal_pupillary_reflex | 1.02949367 |
| 83 | MP0000462_abnormal_digestive_system | 1.02883834 |
| 84 | MP0005058_abnormal_lysosome_morphology | 1.00634963 |
| 85 | MP0001919_abnormal_reproductive_system | 0.99545279 |
| 86 | MP0001299_abnormal_eye_distance/ | 0.99436655 |
| 87 | MP0005389_reproductive_system_phenotype | 0.99382652 |
| 88 | MP0002085_abnormal_embryonic_tissue | 0.99107273 |
| 89 | MP0005390_skeleton_phenotype | 0.98059878 |
| 90 | MP0005380_embryogenesis_phenotype | 0.97869393 |
| 91 | MP0001672_abnormal_embryogenesis/_devel | 0.97869393 |
| 92 | MP0003890_abnormal_embryonic-extraembry | 0.96710168 |
| 93 | MP0005083_abnormal_biliary_tract | 0.94350262 |
| 94 | MP0000681_abnormal_thyroid_gland | 0.94169881 |
| 95 | MP0005395_other_phenotype | 0.93275076 |
| 96 | MP0005508_abnormal_skeleton_morphology | 0.92935872 |
| 97 | MP0001764_abnormal_homeostasis | 0.92415995 |
| 98 | MP0000358_abnormal_cell_content/ | 0.91478811 |
| 99 | MP0009250_abnormal_appendicular_skeleto | 0.90175791 |
| 100 | MP0001666_abnormal_nutrient_absorption | 0.90159905 |
| 101 | MP0002115_abnormal_skeleton_extremities | 0.90108636 |
| 102 | MP0002113_abnormal_skeleton_development | 0.88957376 |
| 103 | MP0001119_abnormal_female_reproductive | 0.88662052 |
| 104 | MP0006036_abnormal_mitochondrial_physio | 0.88574334 |
| 105 | MP0005671_abnormal_response_to | 0.87886363 |
| 106 | MP0000350_abnormal_cell_proliferation | 0.87632725 |
| 107 | MP0010094_abnormal_chromosome_stability | 0.86447405 |
| 108 | MP0004272_abnormal_basement_membrane | 0.85693893 |
| 109 | MP0002111_abnormal_tail_morphology | 0.85319307 |
| 110 | MP0005332_abnormal_amino_acid | 0.85147097 |
| 111 | MP0001756_abnormal_urination | 0.84114574 |
| 112 | MP0002295_abnormal_pulmonary_circulatio | 0.83308238 |
| 113 | MP0002234_abnormal_pharynx_morphology | 0.82867123 |
| 114 | MP0001243_abnormal_dermal_layer | 0.82533333 |
| 115 | MP0000647_abnormal_sebaceous_gland | 0.82089044 |
| 116 | MP0001730_embryonic_growth_arrest | 0.81926928 |
| 117 | MP0003868_abnormal_feces_composition | 0.81744271 |
| 118 | MP0002088_abnormal_embryonic_growth/wei | 0.81385530 |
| 119 | MP0003724_increased_susceptibility_to | 0.80934603 |
| 120 | MP0003984_embryonic_growth_retardation | 0.80907968 |
| 121 | MP0002210_abnormal_sex_determination | 0.80742683 |
| 122 | MP0002928_abnormal_bile_duct | 0.80590280 |
| 123 | MP0003436_decreased_susceptibility_to | 0.80137895 |
| 124 | MP0005023_abnormal_wound_healing | 0.79268961 |
| 125 | MP0000653_abnormal_sex_gland | 0.78928651 |
| 126 | MP0003111_abnormal_nucleus_morphology | 0.78550232 |
| 127 | MP0000049_abnormal_middle_ear | 0.78517056 |
| 128 | MP0003763_abnormal_thymus_physiology | 0.78270121 |
| 129 | MP0004215_abnormal_myocardial_fiber | 0.78054774 |
| 130 | MP0002160_abnormal_reproductive_system | 0.77839031 |
| 131 | MP0003385_abnormal_body_wall | 0.77735801 |
| 132 | MP0003119_abnormal_digestive_system | 0.76968634 |
| 133 | MP0000858_altered_metastatic_potential | 0.76300421 |
| 134 | MP0005085_abnormal_gallbladder_physiolo | 0.76218114 |
| 135 | MP0003786_premature_aging | 0.75883584 |
| 136 | MP0002697_abnormal_eye_size | 0.75223625 |
| 137 | MP0002837_dystrophic_cardiac_calcinosis | 0.74596505 |
| 138 | MP0003252_abnormal_bile_duct | 0.73564972 |
| 139 | MP0001929_abnormal_gametogenesis | 0.73522399 |
| 140 | MP0003942_abnormal_urinary_system | 0.73510088 |
| 141 | MP0001324_abnormal_eye_pigmentation | 0.73345411 |
| 142 | MP0005171_absent_coat_pigmentation | 0.72953184 |
| 143 | MP0001186_pigmentation_phenotype | 0.71829930 |
| 144 | MP0002751_abnormal_autonomic_nervous | 0.71719716 |
| 145 | MP0003315_abnormal_perineum_morphology | 0.71221736 |
| 146 | MP0001145_abnormal_male_reproductive | 0.71030808 |
| 147 | MP0003959_abnormal_lean_body | 0.70931011 |
| 148 | MP0003755_abnormal_palate_morphology | 0.70661220 |
| 149 | MP0001853_heart_inflammation | 0.70630847 |
| 150 | MP0002736_abnormal_nociception_after | 0.70565989 |
| 151 | MP0003718_maternal_effect | 0.70212494 |
| 152 | MP0000003_abnormal_adipose_tissue | 0.70089615 |
| 153 | MP0002080_prenatal_lethality | 0.69901213 |
| 154 | MP0005075_abnormal_melanosome_morpholog | 0.69560892 |
| 155 | MP0010352_gastrointestinal_tract_polyps | 0.68692286 |
| 156 | MP0002148_abnormal_hypersensitivity_rea | 0.68638876 |
| 157 | MP0009384_cardiac_valve_regurgitation | 0.68565877 |
| 158 | MP0000538_abnormal_urinary_bladder | 0.67014297 |
| 159 | MP0004134_abnormal_chest_morphology | 0.66892410 |
| 160 | MP0002282_abnormal_trachea_morphology | 0.65556564 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Type I transferrin isoform profile (HP:0003642) | 4.24811353 |
| 2 | Hypoglycemic coma (HP:0001325) | 4.08183707 |
| 3 | Hyperinsulinemic hypoglycemia (HP:0000825) | 4.00452047 |
| 4 | Symptomatic seizures (HP:0011145) | 3.99090296 |
| 5 | Abnormal protein glycosylation (HP:0012346) | 3.97327370 |
| 6 | Abnormal glycosylation (HP:0012345) | 3.97327370 |
| 7 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 3.97327370 |
| 8 | Abnormal protein N-linked glycosylation (HP:0012347) | 3.97327370 |
| 9 | Hypoglycemic seizures (HP:0002173) | 3.97260318 |
| 10 | Irregular epiphyses (HP:0010582) | 3.79242409 |
| 11 | Epiphyseal dysplasia (HP:0002656) | 3.43636450 |
| 12 | Generalized aminoaciduria (HP:0002909) | 3.41581652 |
| 13 | Reduced antithrombin III activity (HP:0001976) | 3.32691280 |
| 14 | Cerebral edema (HP:0002181) | 3.32444290 |
| 15 | Abnormality of methionine metabolism (HP:0010901) | 3.22074722 |
| 16 | Abnormality of the intrinsic pathway (HP:0010989) | 3.13785026 |
| 17 | Irregular vertebral endplates (HP:0003301) | 3.08237714 |
| 18 | Abnormal pancreas size (HP:0012094) | 3.07347820 |
| 19 | Poor head control (HP:0002421) | 3.01403186 |
| 20 | Beaking of vertebral bodies (HP:0004568) | 2.97827561 |
| 21 | Aplastic anemia (HP:0001915) | 2.97548450 |
| 22 | Methylmalonic acidemia (HP:0002912) | 2.96201809 |
| 23 | Increased serum pyruvate (HP:0003542) | 2.95648072 |
| 24 | Flat capital femoral epiphysis (HP:0003370) | 2.93911392 |
| 25 | Thoracolumbar scoliosis (HP:0002944) | 2.93578674 |
| 26 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.91260602 |
| 27 | Renal Fanconi syndrome (HP:0001994) | 2.87424340 |
| 28 | Abnormality of the anterior horn cell (HP:0006802) | 2.83674311 |
| 29 | Degeneration of anterior horn cells (HP:0002398) | 2.83674311 |
| 30 | Delayed epiphyseal ossification (HP:0002663) | 2.79933116 |
| 31 | 11 pairs of ribs (HP:0000878) | 2.78139556 |
| 32 | Colon cancer (HP:0003003) | 2.76549807 |
| 33 | Meckel diverticulum (HP:0002245) | 2.76236655 |
| 34 | Congenital, generalized hypertrichosis (HP:0004540) | 2.75393533 |
| 35 | Small epiphyses (HP:0010585) | 2.72122854 |
| 36 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 2.68589856 |
| 37 | Abnormality of the vertebral endplates (HP:0005106) | 2.68576081 |
| 38 | Abnormality of endocrine pancreas physiology (HP:0012093) | 2.66021583 |
| 39 | Abnormality of the pancreatic islet cells (HP:0006476) | 2.66021583 |
| 40 | Amniotic constriction ring (HP:0009775) | 2.64614380 |
| 41 | Abnormality of placental membranes (HP:0011409) | 2.64614380 |
| 42 | Increased serum lactate (HP:0002151) | 2.63855425 |
| 43 | Abnormal tarsal ossification (HP:0008369) | 2.62965020 |
| 44 | Abnormality of the ileum (HP:0001549) | 2.60020803 |
| 45 | Abnormality of serum amino acid levels (HP:0003112) | 2.56401247 |
| 46 | Hepatic necrosis (HP:0002605) | 2.54280123 |
| 47 | Abnormality of glycolysis (HP:0004366) | 2.53535323 |
| 48 | Bifid tongue (HP:0010297) | 2.52996627 |
| 49 | Methylmalonic aciduria (HP:0012120) | 2.50916424 |
| 50 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.47722708 |
| 51 | Acute necrotizing encephalopathy (HP:0006965) | 2.47659509 |
| 52 | Lactic acidosis (HP:0003128) | 2.47461667 |
| 53 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.43249542 |
| 54 | 3-Methylglutaconic aciduria (HP:0003535) | 2.41421364 |
| 55 | Hyperglycemia (HP:0003074) | 2.40945707 |
| 56 | Late onset (HP:0003584) | 2.39612816 |
| 57 | Respiratory failure (HP:0002878) | 2.39380242 |
| 58 | Abnormality of chromosome stability (HP:0003220) | 2.39117894 |
| 59 | Cervical subluxation (HP:0003308) | 2.39097290 |
| 60 | Vertebral compression fractures (HP:0002953) | 2.37714508 |
| 61 | Abnormality of the labia minora (HP:0012880) | 2.36587303 |
| 62 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.33673058 |
| 63 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.33642056 |
| 64 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.33642056 |
| 65 | Macrocytic anemia (HP:0001972) | 2.33315834 |
| 66 | Stenosis of the external auditory canal (HP:0000402) | 2.30499281 |
| 67 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.28984341 |
| 68 | Abnormal foot bone ossification (HP:0010675) | 2.28252425 |
| 69 | Abnormal lung lobation (HP:0002101) | 2.27259334 |
| 70 | Hyperglycinemia (HP:0002154) | 2.26500397 |
| 71 | Genu varum (HP:0002970) | 2.24916266 |
| 72 | Short middle phalanx of the 5th finger (HP:0004220) | 2.23376676 |
| 73 | Abnormal number of erythroid precursors (HP:0012131) | 2.23069426 |
| 74 | Mitochondrial inheritance (HP:0001427) | 2.22393976 |
| 75 | Abnormality of alanine metabolism (HP:0010916) | 2.21780610 |
| 76 | Hyperalaninemia (HP:0003348) | 2.21780610 |
| 77 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.21780610 |
| 78 | Vacuolated lymphocytes (HP:0001922) | 2.20108806 |
| 79 | Platyspondyly (HP:0000926) | 2.19395243 |
| 80 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 2.19261218 |
| 81 | Leukodystrophy (HP:0002415) | 2.17778102 |
| 82 | Protuberant abdomen (HP:0001538) | 2.17251415 |
| 83 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.16341892 |
| 84 | Lethargy (HP:0001254) | 2.14397817 |
| 85 | Osteomalacia (HP:0002749) | 2.13547898 |
| 86 | Carpal bone hypoplasia (HP:0001498) | 2.13299706 |
| 87 | Hypothermia (HP:0002045) | 2.13047397 |
| 88 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.12935017 |
| 89 | Abnormality of the preputium (HP:0100587) | 2.11925912 |
| 90 | Respiratory difficulties (HP:0002880) | 2.11615104 |
| 91 | Cupped ribs (HP:0000887) | 2.11443443 |
| 92 | Exercise intolerance (HP:0003546) | 2.10683941 |
| 93 | Supernumerary spleens (HP:0009799) | 2.10583068 |
| 94 | Optic disc pallor (HP:0000543) | 2.10444031 |
| 95 | Nonimmune hydrops fetalis (HP:0001790) | 2.09468041 |
| 96 | Increased CSF lactate (HP:0002490) | 2.09401330 |
| 97 | Thrombocytosis (HP:0001894) | 2.08964336 |
| 98 | Metaphyseal irregularity (HP:0003025) | 2.08791969 |
| 99 | Acute encephalopathy (HP:0006846) | 2.06699447 |
| 100 | Lipid accumulation in hepatocytes (HP:0006561) | 2.04409774 |
| 101 | Vitreoretinal degeneration (HP:0000655) | 2.03337686 |
| 102 | Insulin-resistant diabetes mellitus (HP:0000831) | 2.02777590 |
| 103 | Small intestinal stenosis (HP:0012848) | 2.02489485 |
| 104 | Duodenal stenosis (HP:0100867) | 2.02489485 |
| 105 | Pancreatic fibrosis (HP:0100732) | 2.01382680 |
| 106 | Selective tooth agenesis (HP:0001592) | 2.00845706 |
| 107 | Abnormality of urine glucose concentration (HP:0011016) | 1.99601922 |
| 108 | Glycosuria (HP:0003076) | 1.99601922 |
| 109 | Megaloblastic anemia (HP:0001889) | 1.99589789 |
| 110 | Flattened epiphyses (HP:0003071) | 1.98973106 |
| 111 | Pancreatic cysts (HP:0001737) | 1.98140468 |
| 112 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 1.98084064 |
| 113 | CNS demyelination (HP:0007305) | 1.97569288 |
| 114 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.96780384 |
| 115 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.96562474 |
| 116 | Progressive neurologic deterioration (HP:0002344) | 1.96312524 |
| 117 | Abnormality of the distal phalanges of the toes (HP:0010182) | 1.96309961 |
| 118 | Abnormality of the duodenum (HP:0002246) | 1.94985346 |
| 119 | Protrusio acetabuli (HP:0003179) | 1.94932208 |
| 120 | Increased hepatocellular lipid droplets (HP:0006565) | 1.94678284 |
| 121 | Hyperphosphaturia (HP:0003109) | 1.93614971 |
| 122 | Chromsome breakage (HP:0040012) | 1.93545183 |
| 123 | Microvesicular hepatic steatosis (HP:0001414) | 1.93151224 |
| 124 | Septo-optic dysplasia (HP:0100842) | 1.91774271 |
| 125 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.91477938 |
| 126 | Hepatocellular necrosis (HP:0001404) | 1.91379798 |
| 127 | Abnormality of vitamin B metabolism (HP:0004340) | 1.91194234 |
| 128 | Disproportionate short-trunk short stature (HP:0003521) | 1.90218293 |
| 129 | Metaphyseal cupping (HP:0003021) | 1.89460383 |
| 130 | Large for gestational age (HP:0001520) | 1.89246293 |
| 131 | Reticulocytopenia (HP:0001896) | 1.88976534 |
| 132 | Short tibia (HP:0005736) | 1.88738090 |
| 133 | Absent epiphyses (HP:0010577) | 1.88340450 |
| 134 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.88340450 |
| 135 | Oral leukoplakia (HP:0002745) | 1.87959033 |
| 136 | Missing ribs (HP:0000921) | 1.87858349 |
| 137 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 1.87551727 |
| 138 | Triphalangeal thumb (HP:0001199) | 1.86581782 |
| 139 | Mucopolysacchariduria (HP:0008155) | 1.85754852 |
| 140 | Urinary glycosaminoglycan excretion (HP:0003541) | 1.85754852 |
| 141 | Abnormality involving the epiphyses of the lower limbs (HP:0006500) | 1.84509219 |
| 142 | Abnormality of femoral epiphyses (HP:0006499) | 1.84509219 |
| 143 | Progressive macrocephaly (HP:0004481) | 1.83942745 |
| 144 | Abnormality of renal resorption (HP:0011038) | 1.83134638 |
| 145 | Vertebral hypoplasia (HP:0008417) | 1.81999445 |
| 146 | Aplasia/Hypoplasia of the vertebrae (HP:0008515) | 1.81999445 |
| 147 | Abdominal distention (HP:0003270) | 1.81978913 |
| 148 | Microretrognathia (HP:0000308) | 1.81859899 |
| 149 | Trismus (HP:0000211) | 1.81767985 |
| 150 | Biconcave vertebral bodies (HP:0004586) | 1.81753179 |
| 151 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.81590375 |
| 152 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 1.81161276 |
| 153 | Abnormality of midbrain morphology (HP:0002418) | 1.81051289 |
| 154 | Molar tooth sign on MRI (HP:0002419) | 1.81051289 |
| 155 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.80835702 |
| 156 | Single umbilical artery (HP:0001195) | 1.80835702 |
| 157 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.80835702 |
| 158 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.80491131 |
| 159 | Glossoptosis (HP:0000162) | 1.80089575 |
| 160 | Increased intramyocellular lipid droplets (HP:0012240) | 1.79627747 |
| 161 | Abnormality of the femoral head (HP:0003368) | 1.78427053 |
| 162 | True hermaphroditism (HP:0010459) | 1.77369623 |
| 163 | Abnormality of the epiphysis of the femoral head (HP:0010574) | 1.77171646 |
| 164 | Hypoplasia of the pons (HP:0012110) | 1.76648909 |
| 165 | Type 2 muscle fiber atrophy (HP:0003554) | 1.76313001 |
| 166 | Exertional dyspnea (HP:0002875) | 1.75936514 |
| 167 | Joint stiffness (HP:0001387) | 1.75215687 |
| 168 | Nausea (HP:0002018) | 1.75173509 |
| 169 | Abnormal epiphyseal ossification (HP:0010656) | 1.75085185 |
| 170 | Secondary amenorrhea (HP:0000869) | 1.74083352 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PASK | 4.46586545 |
| 2 | EIF2AK3 | 3.81402205 |
| 3 | VRK2 | 3.55656969 |
| 4 | NME2 | 3.36976489 |
| 5 | STK16 | 2.86826765 |
| 6 | NEK1 | 2.83617883 |
| 7 | BUB1 | 2.66408289 |
| 8 | INSRR | 2.62163749 |
| 9 | FLT3 | 2.59065842 |
| 10 | EIF2AK1 | 2.54427068 |
| 11 | TRIM28 | 2.41685770 |
| 12 | MAP3K3 | 2.34676619 |
| 13 | ERN1 | 2.22004794 |
| 14 | MAP3K12 | 2.19228610 |
| 15 | TESK1 | 1.98622275 |
| 16 | BRSK2 | 1.96313044 |
| 17 | BCKDK | 1.90860543 |
| 18 | VRK1 | 1.90798562 |
| 19 | FRK | 1.87594215 |
| 20 | SRPK1 | 1.87245341 |
| 21 | SCYL2 | 1.82936340 |
| 22 | MAPK15 | 1.82179301 |
| 23 | WEE1 | 1.80246794 |
| 24 | PIM2 | 1.70047924 |
| 25 | TNIK | 1.65846833 |
| 26 | PDK2 | 1.57592948 |
| 27 | ACVR1B | 1.53082423 |
| 28 | TESK2 | 1.52416273 |
| 29 | MAP4K2 | 1.49615598 |
| 30 | MST4 | 1.49512596 |
| 31 | TAF1 | 1.48199133 |
| 32 | IRAK3 | 1.46522087 |
| 33 | PBK | 1.37430593 |
| 34 | NME1 | 1.36409212 |
| 35 | KDR | 1.32269609 |
| 36 | PIK3CG | 1.30112926 |
| 37 | LIMK1 | 1.29855355 |
| 38 | PLK2 | 1.28209242 |
| 39 | HIPK2 | 1.27715570 |
| 40 | TEC | 1.23282700 |
| 41 | BCR | 1.13657629 |
| 42 | ZAK | 1.13392578 |
| 43 | IRAK4 | 1.13143418 |
| 44 | PLK4 | 1.12605185 |
| 45 | BRAF | 1.10239403 |
| 46 | TAOK3 | 1.09966945 |
| 47 | RPS6KA4 | 1.09013194 |
| 48 | MAP3K2 | 1.04307818 |
| 49 | PRKG2 | 1.01568567 |
| 50 | ZAP70 | 1.01398853 |
| 51 | ERBB3 | 0.99015429 |
| 52 | CDK8 | 0.98038595 |
| 53 | EPHA2 | 0.95738052 |
| 54 | GRK1 | 0.94853203 |
| 55 | STK3 | 0.92246037 |
| 56 | DYRK3 | 0.90385086 |
| 57 | NLK | 0.89342649 |
| 58 | CDC7 | 0.86631388 |
| 59 | MUSK | 0.85016272 |
| 60 | TGFBR1 | 0.84870707 |
| 61 | ERBB4 | 0.83381865 |
| 62 | TLK1 | 0.82693073 |
| 63 | PLK3 | 0.82551276 |
| 64 | TSSK6 | 0.81981874 |
| 65 | WNK3 | 0.80656064 |
| 66 | BRSK1 | 0.80523475 |
| 67 | OXSR1 | 0.79026514 |
| 68 | BTK | 0.78310476 |
| 69 | CSNK1G1 | 0.77862600 |
| 70 | MKNK1 | 0.77202816 |
| 71 | EPHA3 | 0.75953070 |
| 72 | TIE1 | 0.75552416 |
| 73 | PRKCI | 0.75183030 |
| 74 | STK39 | 0.75016904 |
| 75 | CHEK2 | 0.74278285 |
| 76 | AURKB | 0.73339361 |
| 77 | YES1 | 0.69969713 |
| 78 | CAMKK2 | 0.69544086 |
| 79 | MAP2K2 | 0.69257002 |
| 80 | CDK7 | 0.68987366 |
| 81 | FGFR1 | 0.68417474 |
| 82 | PLK1 | 0.68075038 |
| 83 | BMPR1B | 0.68049472 |
| 84 | AURKA | 0.67254281 |
| 85 | PAK4 | 0.67048944 |
| 86 | JAK3 | 0.63300720 |
| 87 | CSNK1G3 | 0.63111879 |
| 88 | RPS6KB2 | 0.62804785 |
| 89 | MET | 0.61821906 |
| 90 | EIF2AK2 | 0.60993860 |
| 91 | CSNK2A1 | 0.60737869 |
| 92 | NEK9 | 0.59667673 |
| 93 | DYRK1B | 0.59254371 |
| 94 | PNCK | 0.59040236 |
| 95 | ITK | 0.58329952 |
| 96 | MKNK2 | 0.57464649 |
| 97 | NEK2 | 0.57081504 |
| 98 | AKT3 | 0.56600728 |
| 99 | IRAK1 | 0.55004680 |
| 100 | ARAF | 0.54048164 |
| 101 | CDK19 | 0.53589488 |
| 102 | CSNK1G2 | 0.53184289 |
| 103 | STK4 | 0.51448999 |
| 104 | CSNK2A2 | 0.51027167 |
| 105 | ATR | 0.49929540 |
| 106 | PRKCE | 0.49812577 |
| 107 | MYLK | 0.48727402 |
| 108 | LYN | 0.48716835 |
| 109 | DAPK1 | 0.48653709 |
| 110 | UHMK1 | 0.48148072 |
| 111 | ATM | 0.47180999 |
| 112 | MAP3K11 | 0.46906686 |
| 113 | ABL2 | 0.42221852 |
| 114 | DYRK2 | 0.42142774 |
| 115 | LRRK2 | 0.42023618 |
| 116 | CCNB1 | 0.39691855 |
| 117 | PRKD3 | 0.39600893 |
| 118 | PIM1 | 0.39214848 |
| 119 | CSNK1A1L | 0.37676772 |
| 120 | DAPK3 | 0.37414705 |
| 121 | ADRBK2 | 0.36741736 |
| 122 | NUAK1 | 0.36001383 |
| 123 | WNK4 | 0.35467713 |
| 124 | TGFBR2 | 0.35300893 |
| 125 | CHEK1 | 0.34737677 |
| 126 | RPS6KA5 | 0.32635623 |
| 127 | STK24 | 0.31985364 |
| 128 | CLK1 | 0.31405106 |
| 129 | ILK | 0.31073248 |
| 130 | MAP3K8 | 0.30945469 |
| 131 | DDR2 | 0.30689409 |
| 132 | PAK3 | 0.29626892 |
| 133 | STK38L | 0.29431823 |
| 134 | ALK | 0.29097893 |
| 135 | STK10 | 0.28822877 |
| 136 | PAK1 | 0.27806926 |
| 137 | KIT | 0.27709939 |
| 138 | CDK3 | 0.27697266 |
| 139 | TTK | 0.27302033 |
| 140 | MAP3K4 | 0.27250613 |
| 141 | GRK7 | 0.26912492 |
| 142 | PRKCG | 0.26739580 |
| 143 | ADRBK1 | 0.24738792 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Protein export_Homo sapiens_hsa03060 | 6.96316030 |
| 2 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 4.83055448 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 3.43587433 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.03643746 |
| 5 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 2.95636405 |
| 6 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.45100654 |
| 7 | DNA replication_Homo sapiens_hsa03030 | 2.34305744 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.24770123 |
| 9 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 2.14617168 |
| 10 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 2.06285144 |
| 11 | Mismatch repair_Homo sapiens_hsa03430 | 1.98311901 |
| 12 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.93896280 |
| 13 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.92469761 |
| 14 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.89827904 |
| 15 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.86642511 |
| 16 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.81319908 |
| 17 | Spliceosome_Homo sapiens_hsa03040 | 1.70514390 |
| 18 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.65565487 |
| 19 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.63688929 |
| 20 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.61792985 |
| 21 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.56159925 |
| 22 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.53362607 |
| 23 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.51944730 |
| 24 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.49462902 |
| 25 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.47467379 |
| 26 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.40469834 |
| 27 | RNA transport_Homo sapiens_hsa03013 | 1.39095587 |
| 28 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.37397230 |
| 29 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.36492293 |
| 30 | Homologous recombination_Homo sapiens_hsa03440 | 1.34662006 |
| 31 | Base excision repair_Homo sapiens_hsa03410 | 1.34628517 |
| 32 | Other glycan degradation_Homo sapiens_hsa00511 | 1.33332705 |
| 33 | Parkinsons disease_Homo sapiens_hsa05012 | 1.29249710 |
| 34 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.23334233 |
| 35 | Basal transcription factors_Homo sapiens_hsa03022 | 1.20344801 |
| 36 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.17946966 |
| 37 | Galactose metabolism_Homo sapiens_hsa00052 | 1.14462960 |
| 38 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.13539720 |
| 39 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.13018649 |
| 40 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.08897189 |
| 41 | RNA degradation_Homo sapiens_hsa03018 | 1.06733507 |
| 42 | Purine metabolism_Homo sapiens_hsa00230 | 0.97764568 |
| 43 | Legionellosis_Homo sapiens_hsa05134 | 0.97321635 |
| 44 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.96970155 |
| 45 | Huntingtons disease_Homo sapiens_hsa05016 | 0.96317127 |
| 46 | Cell cycle_Homo sapiens_hsa04110 | 0.95273696 |
| 47 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.91281024 |
| 48 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.89231081 |
| 49 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.88721225 |
| 50 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.88510690 |
| 51 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.88473436 |
| 52 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.87831711 |
| 53 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.87234432 |
| 54 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.84551661 |
| 55 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.84174864 |
| 56 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.81580634 |
| 57 | Alzheimers disease_Homo sapiens_hsa05010 | 0.80481877 |
| 58 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.80136297 |
| 59 | Lysosome_Homo sapiens_hsa04142 | 0.79736843 |
| 60 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.75748683 |
| 61 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.72448945 |
| 62 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.71924305 |
| 63 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.71489664 |
| 64 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.71280874 |
| 65 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.71089198 |
| 66 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.70855318 |
| 67 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.69461477 |
| 68 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.67727110 |
| 69 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.66922935 |
| 70 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.66816407 |
| 71 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.63666382 |
| 72 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.62241785 |
| 73 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.61561907 |
| 74 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.59148367 |
| 75 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.59102743 |
| 76 | Retinol metabolism_Homo sapiens_hsa00830 | 0.59014971 |
| 77 | Metabolic pathways_Homo sapiens_hsa01100 | 0.58497576 |
| 78 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.58412971 |
| 79 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.57867042 |
| 80 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.57744740 |
| 81 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.57480689 |
| 82 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.54868428 |
| 83 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.54486971 |
| 84 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.53505541 |
| 85 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.52036783 |
| 86 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.52012814 |
| 87 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.50980832 |
| 88 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.50673397 |
| 89 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.50206787 |
| 90 | Phagosome_Homo sapiens_hsa04145 | 0.50016688 |
| 91 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.48184990 |
| 92 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.45966948 |
| 93 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.44147376 |
| 94 | Sulfur relay system_Homo sapiens_hsa04122 | 0.43307850 |
| 95 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.42484396 |
| 96 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.41650272 |
| 97 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.39839013 |
| 98 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.39605948 |
| 99 | Thyroid cancer_Homo sapiens_hsa05216 | 0.39068008 |
| 100 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.38817388 |
| 101 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.38329453 |
| 102 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.36645809 |
| 103 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.36019749 |
| 104 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.35856631 |
| 105 | Phototransduction_Homo sapiens_hsa04744 | 0.33368950 |
| 106 | Histidine metabolism_Homo sapiens_hsa00340 | 0.31826814 |
| 107 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.31816203 |
| 108 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.31168474 |
| 109 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.31025862 |
| 110 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.29902876 |
| 111 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.29876264 |
| 112 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.28553459 |
| 113 | Asthma_Homo sapiens_hsa05310 | 0.27831187 |
| 114 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.26631152 |
| 115 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.25256698 |
| 116 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.25098737 |
| 117 | Mineral absorption_Homo sapiens_hsa04978 | 0.24476863 |
| 118 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.24449573 |
| 119 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.24375564 |
| 120 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.23637616 |
| 121 | Insulin secretion_Homo sapiens_hsa04911 | 0.22181474 |
| 122 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.21099103 |
| 123 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.20877193 |
| 124 | Alcoholism_Homo sapiens_hsa05034 | 0.20256067 |
| 125 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.19559141 |
| 126 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.18760772 |
| 127 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.18508139 |
| 128 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.17148722 |
| 129 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.16886497 |
| 130 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.13613789 |
| 131 | Apoptosis_Homo sapiens_hsa04210 | 0.13285532 |
| 132 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.11885429 |
| 133 | Peroxisome_Homo sapiens_hsa04146 | 0.11109150 |
| 134 | Carbon metabolism_Homo sapiens_hsa01200 | 0.10797277 |
| 135 | Malaria_Homo sapiens_hsa05144 | 0.10665868 |

