OSTC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)9.40123926
2COPI coating of Golgi vesicle (GO:0048205)9.40123926
3signal peptide processing (GO:0006465)7.72334616
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.52512738
5protein retention in ER lumen (GO:0006621)5.76003353
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.57065987
7protein maturation by protein folding (GO:0022417)5.17428532
8COPII vesicle coating (GO:0048208)5.01816016
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.94690761
10cotranslational protein targeting to membrane (GO:0006613)4.84779315
11protein targeting to ER (GO:0045047)4.82896765
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.74218993
13ATP synthesis coupled proton transport (GO:0015986)4.74218993
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.73406986
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.71263625
16protein localization to endoplasmic reticulum (GO:0070972)4.59080932
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.57569140
18DNA deamination (GO:0045006)4.43486947
19CENP-A containing nucleosome assembly (GO:0034080)4.40819393
20chromatin remodeling at centromere (GO:0031055)4.36812431
21ribosomal small subunit assembly (GO:0000028)4.29505031
22chaperone-mediated protein transport (GO:0072321)4.29262230
23GDP-mannose metabolic process (GO:0019673)4.25397358
24protein neddylation (GO:0045116)4.18458713
25sequestering of metal ion (GO:0051238)4.10639910
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.93548124
27cullin deneddylation (GO:0010388)3.76518952
28exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.72026514
29nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.69393384
30DNA double-strand break processing (GO:0000729)3.66083657
31activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.64778434
32histone exchange (GO:0043486)3.64567099
33respiratory electron transport chain (GO:0022904)3.64496679
34proteasome assembly (GO:0043248)3.63999908
35positive regulation of nuclease activity (GO:0032075)3.62921303
36protein deneddylation (GO:0000338)3.60662801
37formation of translation preinitiation complex (GO:0001731)3.59924891
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.59338824
39endocrine pancreas development (GO:0031018)3.57174396
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.56484949
41termination of RNA polymerase III transcription (GO:0006386)3.56484949
42positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.56297691
43electron transport chain (GO:0022900)3.55921858
44protein complex biogenesis (GO:0070271)3.51439328
45ER overload response (GO:0006983)3.50949989
46translation (GO:0006412)3.50406205
47nucleotide-sugar biosynthetic process (GO:0009226)3.48364291
48vesicle coating (GO:0006901)3.47983741
49pteridine-containing compound biosynthetic process (GO:0042559)3.47978136
50ribosome assembly (GO:0042255)3.47851022
51mitochondrial respiratory chain complex assembly (GO:0033108)3.44878704
52folic acid-containing compound biosynthetic process (GO:0009396)3.44321623
53antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.42538413
54positive regulation of ligase activity (GO:0051351)3.40232789
55regulation of nuclease activity (GO:0032069)3.37875950
56antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.36500016
57peptide hormone processing (GO:0016486)3.36224461
58* protein N-linked glycosylation via asparagine (GO:0018279)3.36059369
59mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34516144
60mitochondrial respiratory chain complex I assembly (GO:0032981)3.34516144
61NADH dehydrogenase complex assembly (GO:0010257)3.34516144
62DNA replication checkpoint (GO:0000076)3.33925015
63rRNA modification (GO:0000154)3.30917176
64* peptidyl-asparagine modification (GO:0018196)3.30076811
65mitotic metaphase plate congression (GO:0007080)3.29655557
66exocrine pancreas development (GO:0031017)3.28084018
67endoplasmic reticulum unfolded protein response (GO:0030968)3.27669188
68peptidyl-histidine modification (GO:0018202)3.27181122
69dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.27113031
70protein peptidyl-prolyl isomerization (GO:0000413)3.26241451
71regulation of mitotic spindle checkpoint (GO:1903504)3.25014879
72regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.25014879
73deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.24275435
74histone mRNA metabolic process (GO:0008334)3.23874242
75regulation of ubiquitin-protein transferase activity (GO:0051438)3.22634320
76DNA replication-independent nucleosome organization (GO:0034724)3.22410352
77DNA replication-independent nucleosome assembly (GO:0006336)3.22410352
78tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22103426
79RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22103426
80regulation of type B pancreatic cell apoptotic process (GO:2000674)3.21744981
81cellular response to unfolded protein (GO:0034620)3.21452782
82ER to Golgi vesicle-mediated transport (GO:0006888)3.19453445
83deoxyribose phosphate biosynthetic process (GO:0046385)3.19446371
842-deoxyribonucleotide biosynthetic process (GO:0009265)3.19446371
85* protein N-linked glycosylation (GO:0006487)3.18660457
86viral transcription (GO:0019083)3.17921341
87cellular response to topologically incorrect protein (GO:0035967)3.17859804
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17632710
89DNA catabolic process, exonucleolytic (GO:0000738)3.17227658
90translational termination (GO:0006415)3.16947537
91protein targeting to membrane (GO:0006612)3.16029760
92proline biosynthetic process (GO:0006561)3.15951326
93establishment of viral latency (GO:0019043)3.15461019
94cytochrome complex assembly (GO:0017004)3.14647963
95UDP-N-acetylglucosamine metabolic process (GO:0006047)3.14028635
96ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.13158285
97spliceosomal snRNP assembly (GO:0000387)3.12884514
98regulation of ligase activity (GO:0051340)3.10544700
99DNA ligation (GO:0006266)3.09766629
100oxidative phosphorylation (GO:0006119)3.09743935
101nucleobase-containing small molecule interconversion (GO:0015949)3.05698961
102chaperone-mediated protein folding (GO:0061077)3.03989559
103regulation of protein heterodimerization activity (GO:0043497)3.03764299
104metaphase plate congression (GO:0051310)3.03411607
105protein targeting to mitochondrion (GO:0006626)3.02913229
106glandular epithelial cell differentiation (GO:0002067)3.00843179
107peptidyl-proline modification (GO:0018208)3.00396892
108ribosomal small subunit biogenesis (GO:0042274)3.00149992
109positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99143763
110IMP biosynthetic process (GO:0006188)2.98561383
111regulation of cellular amino acid metabolic process (GO:0006521)2.96789817
112ER-nucleus signaling pathway (GO:0006984)2.96299268
113inner mitochondrial membrane organization (GO:0007007)2.93474649
114aldehyde catabolic process (GO:0046185)2.92342894
115translational elongation (GO:0006414)2.91810168
116DNA damage response, detection of DNA damage (GO:0042769)2.90877223
117negative regulation of DNA-dependent DNA replication (GO:2000104)2.89864703
118regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88558233
119negative regulation of ligase activity (GO:0051352)2.88208772
120negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.88208772
121pseudouridine synthesis (GO:0001522)2.86632863
122maturation of 5.8S rRNA (GO:0000460)2.86572870
123negative regulation of protein ubiquitination (GO:0031397)2.86197712
124kinetochore organization (GO:0051383)2.84655980
125DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84522716
126kinetochore assembly (GO:0051382)2.83915584
127nucleobase biosynthetic process (GO:0046112)2.83861791
128G1/S transition of mitotic cell cycle (GO:0000082)2.83774174
129cell cycle G1/S phase transition (GO:0044843)2.83774174
130nucleotide transmembrane transport (GO:1901679)2.82719665
131protein localization to mitochondrion (GO:0070585)2.82148189
132cell redox homeostasis (GO:0045454)2.82138222
133rRNA methylation (GO:0031167)2.82119308
134regulation of cellular amine metabolic process (GO:0033238)2.81345494
135regulation of mitochondrial translation (GO:0070129)2.79744269
136positive regulation of cell cycle arrest (GO:0071158)2.79566427
137signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79383903
138intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79383903
139water-soluble vitamin biosynthetic process (GO:0042364)2.79292424
140signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.78789524
141signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.78789524
142signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.78789524
143establishment of protein localization to mitochondrion (GO:0072655)2.78296731
144translational initiation (GO:0006413)2.78293164
145nucleotide-sugar metabolic process (GO:0009225)2.77930171
146DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.76879728
147deoxyribonucleotide biosynthetic process (GO:0009263)2.76397761
148L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.75979301
149ribosomal large subunit biogenesis (GO:0042273)2.74979381
150purine nucleobase biosynthetic process (GO:0009113)2.73461661
151regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.71100772
152anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.71033746
153response to endoplasmic reticulum stress (GO:0034976)2.70815200
154guanosine-containing compound biosynthetic process (GO:1901070)2.69681177
155signal transduction involved in DNA damage checkpoint (GO:0072422)2.69192180
156signal transduction involved in DNA integrity checkpoint (GO:0072401)2.69192180
157viral life cycle (GO:0019058)2.67818868
1587-methylguanosine mRNA capping (GO:0006370)2.66844390
159telomere maintenance via semi-conservative replication (GO:0032201)2.65201957
160respiratory chain complex IV assembly (GO:0008535)2.64642179
161signal transduction involved in cell cycle checkpoint (GO:0072395)2.62658424
1627-methylguanosine RNA capping (GO:0009452)2.59497002
163RNA capping (GO:0036260)2.59497002
164establishment of integrated proviral latency (GO:0075713)2.58394165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.79470558
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.41909611
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.83207732
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.69595925
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.68428477
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.68056496
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.64717456
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.63953149
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.58856662
10E2F7_22180533_ChIP-Seq_HELA_Human3.53722203
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.30110839
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.17919742
13PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.87459822
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.74779557
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72660934
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56978135
17* VDR_23849224_ChIP-Seq_CD4+_Human2.56800467
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50495640
19DCP1A_22483619_ChIP-Seq_HELA_Human2.45464319
20ELK1_19687146_ChIP-ChIP_HELA_Human2.43030301
21E2F1_18555785_ChIP-Seq_MESCs_Mouse2.41894101
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.36869033
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27269202
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25553979
25GABP_19822575_ChIP-Seq_HepG2_Human2.23619813
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22619003
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.18173917
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17326017
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17120170
30DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.16566454
31* FOXP3_21729870_ChIP-Seq_TREG_Human2.13414591
32XRN2_22483619_ChIP-Seq_HELA_Human2.12160436
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.10321077
34SRF_21415370_ChIP-Seq_HL-1_Mouse2.10010496
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09196254
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94700305
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92407089
38ERG_20887958_ChIP-Seq_HPC-7_Mouse1.90252281
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84350810
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82579077
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.81740612
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.81613710
43EWS_26573619_Chip-Seq_HEK293_Human1.78422689
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76115199
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75799670
46TTF2_22483619_ChIP-Seq_HELA_Human1.75500525
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.70640406
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.70511852
49TFEB_21752829_ChIP-Seq_HELA_Human1.68463772
50FUS_26573619_Chip-Seq_HEK293_Human1.67033729
51VDR_22108803_ChIP-Seq_LS180_Human1.65011045
52ZNF274_21170338_ChIP-Seq_K562_Hela1.59650355
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56305599
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.55942805
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55731381
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.52413790
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50757960
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.48596398
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45677360
60NANOG_16153702_ChIP-ChIP_HESCs_Human1.45321009
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43329585
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43001193
63GATA1_22025678_ChIP-Seq_K562_Human1.41312713
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40268281
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37869535
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36245193
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34940054
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33887002
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33023457
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32491524
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28106317
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27808121
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25515988
74CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.24311954
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23030900
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21870523
77P300_19829295_ChIP-Seq_ESCs_Human1.20161414
78KDM5A_27292631_Chip-Seq_BREAST_Human1.18633447
79CIITA_25753668_ChIP-Seq_RAJI_Human1.18374894
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18214284
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16786630
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.16679995
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16087924
84FOXM1_23109430_ChIP-Seq_U2OS_Human1.14686713
85AR_21909140_ChIP-Seq_LNCAP_Human1.14093386
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12803904
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12389997
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11561320
89SPI1_23547873_ChIP-Seq_NB4_Human1.08743615
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08592370
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08099988
92SOX17_20123909_ChIP-Seq_XEN_Mouse1.06575013
93TAF15_26573619_Chip-Seq_HEK293_Human1.03158131
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03123701
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02126253
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.01830793
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01518608
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00668675
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98296781
100SOX2_16153702_ChIP-ChIP_HESCs_Human0.98248334
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98071933
102PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96406471
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95764482
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95269304
105SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95082708
106NOTCH1_21737748_ChIP-Seq_TLL_Human0.92993585
107NFE2_27457419_Chip-Seq_LIVER_Mouse0.92085071
108TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91522913
109* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91239657
110EGR1_19374776_ChIP-ChIP_THP-1_Human0.88280500
111NANOG_19829295_ChIP-Seq_ESCs_Human0.87901309
112SOX2_19829295_ChIP-Seq_ESCs_Human0.87901309
113ELF5_23300383_ChIP-Seq_T47D_Human0.86041873
114FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85781171
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84452715
116IGF1R_20145208_ChIP-Seq_DFB_Human0.83835220
117SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82449767
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81442718
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80928917
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78386014
121SALL4_22934838_ChIP-ChIP_CD34+_Human0.78122364
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78096013
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77744541
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.77666889
125ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76665921
126MYC_18940864_ChIP-ChIP_HL60_Human0.76305557
127NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.76207978
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75828093
129PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.75676364
130* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.75557953
131EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.75552064
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.75309658
133KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75137057
134KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.72993403
135MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.72389104
136TP53_22573176_ChIP-Seq_HFKS_Human0.72234078
137KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.70561836
138DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.69894131

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.76697500
2MP0006054_spinal_hemorrhage3.21474847
3MP0003941_abnormal_skin_development3.20461302
4MP0002877_abnormal_melanocyte_morpholog3.01238564
5MP0005220_abnormal_exocrine_pancreas2.92428889
6MP0003195_calcinosis2.63169020
7MP0008438_abnormal_cutaneous_collagen2.60303561
8MP0002693_abnormal_pancreas_physiology2.59904858
9MP0004957_abnormal_blastocyst_morpholog2.58409322
10MP0001944_abnormal_pancreas_morphology2.50270292
11MP0010030_abnormal_orbit_morphology2.39589702
12MP0003283_abnormal_digestive_organ2.27738811
13MP0005379_endocrine/exocrine_gland_phen2.26045195
14MP0000013_abnormal_adipose_tissue2.23929456
15MP0010386_abnormal_urinary_bladder2.21417466
16MP0004043_abnormal_pH_regulation2.16837833
17MP0005503_abnormal_tendon_morphology2.15289398
18MP0005408_hypopigmentation2.10187323
19MP0003806_abnormal_nucleotide_metabolis2.05625040
20MP0002102_abnormal_ear_morphology2.04543316
21MP0000678_abnormal_parathyroid_gland2.03428761
22MP0003183_abnormal_peptide_metabolism1.95552269
23MP0002933_joint_inflammation1.92805189
24MP0003123_paternal_imprinting1.92600991
25MP0001293_anophthalmia1.92187307
26MP0003186_abnormal_redox_activity1.77943812
27MP0000372_irregular_coat_pigmentation1.76955236
28MP0006292_abnormal_olfactory_placode1.73780435
29MP0008057_abnormal_DNA_replication1.67586170
30MP0003567_abnormal_fetal_cardiomyocyte1.65759699
31MP0001529_abnormal_vocalization1.63036707
32MP0005084_abnormal_gallbladder_morpholo1.62150871
33MP0001542_abnormal_bone_strength1.61365036
34MP0003122_maternal_imprinting1.58839435
35MP0009333_abnormal_splenocyte_physiolog1.57853043
36MP0003937_abnormal_limbs/digits/tail_de1.57546841
37MP0004147_increased_porphyrin_level1.54655280
38MP0002896_abnormal_bone_mineralization1.51025865
39MP0008932_abnormal_embryonic_tissue1.49270089
40MP0002909_abnormal_adrenal_gland1.46107872
41MP0003950_abnormal_plasma_membrane1.44972181
42MP0002254_reproductive_system_inflammat1.44640178
43MP0009780_abnormal_chondrocyte_physiolo1.42150656
44MP0008877_abnormal_DNA_methylation1.42060540
45MP0009379_abnormal_foot_pigmentation1.40838424
46MP0009697_abnormal_copulation1.40023985
47MP0003136_yellow_coat_color1.36686237
48MP0004264_abnormal_extraembryonic_tissu1.36670449
49MP0008007_abnormal_cellular_replicative1.32098271
50MP0000516_abnormal_urinary_system1.31047517
51MP0005367_renal/urinary_system_phenotyp1.31047517
52MP0002090_abnormal_vision1.30305080
53MP0002163_abnormal_gland_morphology1.29696893
54MP0004133_heterotaxia1.28867428
55MP0008789_abnormal_olfactory_epithelium1.27624184
56MP0002233_abnormal_nose_morphology1.26885607
57MP0003011_delayed_dark_adaptation1.26433662
58MP0003795_abnormal_bone_structure1.25864070
59MP0003077_abnormal_cell_cycle1.24592135
60MP0000163_abnormal_cartilage_morphology1.24191982
61MP0008058_abnormal_DNA_repair1.22396736
62MP0002938_white_spotting1.22268189
63MP0005257_abnormal_intraocular_pressure1.20821945
64MP0006035_abnormal_mitochondrial_morpho1.14735514
65MP0004782_abnormal_surfactant_physiolog1.14232921
66MP0001986_abnormal_taste_sensitivity1.11914928
67MP0001286_abnormal_eye_development1.11645564
68MP0009643_abnormal_urine_homeostasis1.10943525
69MP0000613_abnormal_salivary_gland1.10577552
70MP0001348_abnormal_lacrimal_gland1.09652760
71MP0001697_abnormal_embryo_size1.09380072
72MP0005636_abnormal_mineral_homeostasis1.09147008
73MP0006072_abnormal_retinal_apoptosis1.09087476
74MP0008995_early_reproductive_senescence1.08428568
75MP0002084_abnormal_developmental_patter1.08191361
76MP0005275_abnormal_skin_tensile1.07541199
77MP0001533_abnormal_skeleton_physiology1.05401706
78MP0002078_abnormal_glucose_homeostasis1.04570804
79MP0005360_urolithiasis1.03776658
80MP0005253_abnormal_eye_physiology1.03415275
81MP0000490_abnormal_crypts_of1.03347368
82MP0002638_abnormal_pupillary_reflex1.02949367
83MP0000462_abnormal_digestive_system1.02883834
84MP0005058_abnormal_lysosome_morphology1.00634963
85MP0001919_abnormal_reproductive_system0.99545279
86MP0001299_abnormal_eye_distance/0.99436655
87MP0005389_reproductive_system_phenotype0.99382652
88MP0002085_abnormal_embryonic_tissue0.99107273
89MP0005390_skeleton_phenotype0.98059878
90MP0005380_embryogenesis_phenotype0.97869393
91MP0001672_abnormal_embryogenesis/_devel0.97869393
92MP0003890_abnormal_embryonic-extraembry0.96710168
93MP0005083_abnormal_biliary_tract0.94350262
94MP0000681_abnormal_thyroid_gland0.94169881
95MP0005395_other_phenotype0.93275076
96MP0005508_abnormal_skeleton_morphology0.92935872
97MP0001764_abnormal_homeostasis0.92415995
98MP0000358_abnormal_cell_content/0.91478811
99MP0009250_abnormal_appendicular_skeleto0.90175791
100MP0001666_abnormal_nutrient_absorption0.90159905
101MP0002115_abnormal_skeleton_extremities0.90108636
102MP0002113_abnormal_skeleton_development0.88957376
103MP0001119_abnormal_female_reproductive0.88662052
104MP0006036_abnormal_mitochondrial_physio0.88574334
105MP0005671_abnormal_response_to0.87886363
106MP0000350_abnormal_cell_proliferation0.87632725
107MP0010094_abnormal_chromosome_stability0.86447405
108MP0004272_abnormal_basement_membrane0.85693893
109MP0002111_abnormal_tail_morphology0.85319307
110MP0005332_abnormal_amino_acid0.85147097
111MP0001756_abnormal_urination0.84114574
112MP0002295_abnormal_pulmonary_circulatio0.83308238
113MP0002234_abnormal_pharynx_morphology0.82867123
114MP0001243_abnormal_dermal_layer0.82533333
115MP0000647_abnormal_sebaceous_gland0.82089044
116MP0001730_embryonic_growth_arrest0.81926928
117MP0003868_abnormal_feces_composition0.81744271
118MP0002088_abnormal_embryonic_growth/wei0.81385530
119MP0003724_increased_susceptibility_to0.80934603
120MP0003984_embryonic_growth_retardation0.80907968
121MP0002210_abnormal_sex_determination0.80742683
122MP0002928_abnormal_bile_duct0.80590280
123MP0003436_decreased_susceptibility_to0.80137895
124MP0005023_abnormal_wound_healing0.79268961
125MP0000653_abnormal_sex_gland0.78928651
126MP0003111_abnormal_nucleus_morphology0.78550232
127MP0000049_abnormal_middle_ear0.78517056
128MP0003763_abnormal_thymus_physiology0.78270121
129MP0004215_abnormal_myocardial_fiber0.78054774
130MP0002160_abnormal_reproductive_system0.77839031
131MP0003385_abnormal_body_wall0.77735801
132MP0003119_abnormal_digestive_system0.76968634
133MP0000858_altered_metastatic_potential0.76300421
134MP0005085_abnormal_gallbladder_physiolo0.76218114
135MP0003786_premature_aging0.75883584
136MP0002697_abnormal_eye_size0.75223625
137MP0002837_dystrophic_cardiac_calcinosis0.74596505
138MP0003252_abnormal_bile_duct0.73564972
139MP0001929_abnormal_gametogenesis0.73522399
140MP0003942_abnormal_urinary_system0.73510088
141MP0001324_abnormal_eye_pigmentation0.73345411
142MP0005171_absent_coat_pigmentation0.72953184
143MP0001186_pigmentation_phenotype0.71829930
144MP0002751_abnormal_autonomic_nervous0.71719716
145MP0003315_abnormal_perineum_morphology0.71221736
146MP0001145_abnormal_male_reproductive0.71030808
147MP0003959_abnormal_lean_body0.70931011
148MP0003755_abnormal_palate_morphology0.70661220
149MP0001853_heart_inflammation0.70630847
150MP0002736_abnormal_nociception_after0.70565989
151MP0003718_maternal_effect0.70212494
152MP0000003_abnormal_adipose_tissue0.70089615
153MP0002080_prenatal_lethality0.69901213
154MP0005075_abnormal_melanosome_morpholog0.69560892
155MP0010352_gastrointestinal_tract_polyps0.68692286
156MP0002148_abnormal_hypersensitivity_rea0.68638876
157MP0009384_cardiac_valve_regurgitation0.68565877
158MP0000538_abnormal_urinary_bladder0.67014297
159MP0004134_abnormal_chest_morphology0.66892410
160MP0002282_abnormal_trachea_morphology0.65556564

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)4.24811353
2Hypoglycemic coma (HP:0001325)4.08183707
3Hyperinsulinemic hypoglycemia (HP:0000825)4.00452047
4Symptomatic seizures (HP:0011145)3.99090296
5Abnormal protein glycosylation (HP:0012346)3.97327370
6Abnormal glycosylation (HP:0012345)3.97327370
7Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.97327370
8Abnormal protein N-linked glycosylation (HP:0012347)3.97327370
9Hypoglycemic seizures (HP:0002173)3.97260318
10Irregular epiphyses (HP:0010582)3.79242409
11Epiphyseal dysplasia (HP:0002656)3.43636450
12Generalized aminoaciduria (HP:0002909)3.41581652
13Reduced antithrombin III activity (HP:0001976)3.32691280
14Cerebral edema (HP:0002181)3.32444290
15Abnormality of methionine metabolism (HP:0010901)3.22074722
16Abnormality of the intrinsic pathway (HP:0010989)3.13785026
17Irregular vertebral endplates (HP:0003301)3.08237714
18Abnormal pancreas size (HP:0012094)3.07347820
19Poor head control (HP:0002421)3.01403186
20Beaking of vertebral bodies (HP:0004568)2.97827561
21Aplastic anemia (HP:0001915)2.97548450
22Methylmalonic acidemia (HP:0002912)2.96201809
23Increased serum pyruvate (HP:0003542)2.95648072
24Flat capital femoral epiphysis (HP:0003370)2.93911392
25Thoracolumbar scoliosis (HP:0002944)2.93578674
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.91260602
27Renal Fanconi syndrome (HP:0001994)2.87424340
28Abnormality of the anterior horn cell (HP:0006802)2.83674311
29Degeneration of anterior horn cells (HP:0002398)2.83674311
30Delayed epiphyseal ossification (HP:0002663)2.79933116
3111 pairs of ribs (HP:0000878)2.78139556
32Colon cancer (HP:0003003)2.76549807
33Meckel diverticulum (HP:0002245)2.76236655
34Congenital, generalized hypertrichosis (HP:0004540)2.75393533
35Small epiphyses (HP:0010585)2.72122854
36Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.68589856
37Abnormality of the vertebral endplates (HP:0005106)2.68576081
38Abnormality of endocrine pancreas physiology (HP:0012093)2.66021583
39Abnormality of the pancreatic islet cells (HP:0006476)2.66021583
40Amniotic constriction ring (HP:0009775)2.64614380
41Abnormality of placental membranes (HP:0011409)2.64614380
42Increased serum lactate (HP:0002151)2.63855425
43Abnormal tarsal ossification (HP:0008369)2.62965020
44Abnormality of the ileum (HP:0001549)2.60020803
45Abnormality of serum amino acid levels (HP:0003112)2.56401247
46Hepatic necrosis (HP:0002605)2.54280123
47Abnormality of glycolysis (HP:0004366)2.53535323
48Bifid tongue (HP:0010297)2.52996627
49Methylmalonic aciduria (HP:0012120)2.50916424
50Pancreatic islet-cell hyperplasia (HP:0004510)2.47722708
51Acute necrotizing encephalopathy (HP:0006965)2.47659509
52Lactic acidosis (HP:0003128)2.47461667
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.43249542
543-Methylglutaconic aciduria (HP:0003535)2.41421364
55Hyperglycemia (HP:0003074)2.40945707
56Late onset (HP:0003584)2.39612816
57Respiratory failure (HP:0002878)2.39380242
58Abnormality of chromosome stability (HP:0003220)2.39117894
59Cervical subluxation (HP:0003308)2.39097290
60Vertebral compression fractures (HP:0002953)2.37714508
61Abnormality of the labia minora (HP:0012880)2.36587303
62Abnormal mitochondria in muscle tissue (HP:0008316)2.33673058
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33642056
64Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33642056
65Macrocytic anemia (HP:0001972)2.33315834
66Stenosis of the external auditory canal (HP:0000402)2.30499281
67Abnormality of cells of the erythroid lineage (HP:0012130)2.28984341
68Abnormal foot bone ossification (HP:0010675)2.28252425
69Abnormal lung lobation (HP:0002101)2.27259334
70Hyperglycinemia (HP:0002154)2.26500397
71Genu varum (HP:0002970)2.24916266
72Short middle phalanx of the 5th finger (HP:0004220)2.23376676
73Abnormal number of erythroid precursors (HP:0012131)2.23069426
74Mitochondrial inheritance (HP:0001427)2.22393976
75Abnormality of alanine metabolism (HP:0010916)2.21780610
76Hyperalaninemia (HP:0003348)2.21780610
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21780610
78Vacuolated lymphocytes (HP:0001922)2.20108806
79Platyspondyly (HP:0000926)2.19395243
80Abnormality of calcium-phosphate metabolism (HP:0100530)2.19261218
81Leukodystrophy (HP:0002415)2.17778102
82Protuberant abdomen (HP:0001538)2.17251415
83Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16341892
84Lethargy (HP:0001254)2.14397817
85Osteomalacia (HP:0002749)2.13547898
86Carpal bone hypoplasia (HP:0001498)2.13299706
87Hypothermia (HP:0002045)2.13047397
88Aplasia/Hypoplasia of the sacrum (HP:0008517)2.12935017
89Abnormality of the preputium (HP:0100587)2.11925912
90Respiratory difficulties (HP:0002880)2.11615104
91Cupped ribs (HP:0000887)2.11443443
92Exercise intolerance (HP:0003546)2.10683941
93Supernumerary spleens (HP:0009799)2.10583068
94Optic disc pallor (HP:0000543)2.10444031
95Nonimmune hydrops fetalis (HP:0001790)2.09468041
96Increased CSF lactate (HP:0002490)2.09401330
97Thrombocytosis (HP:0001894)2.08964336
98Metaphyseal irregularity (HP:0003025)2.08791969
99Acute encephalopathy (HP:0006846)2.06699447
100Lipid accumulation in hepatocytes (HP:0006561)2.04409774
101Vitreoretinal degeneration (HP:0000655)2.03337686
102Insulin-resistant diabetes mellitus (HP:0000831)2.02777590
103Small intestinal stenosis (HP:0012848)2.02489485
104Duodenal stenosis (HP:0100867)2.02489485
105Pancreatic fibrosis (HP:0100732)2.01382680
106Selective tooth agenesis (HP:0001592)2.00845706
107Abnormality of urine glucose concentration (HP:0011016)1.99601922
108Glycosuria (HP:0003076)1.99601922
109Megaloblastic anemia (HP:0001889)1.99589789
110Flattened epiphyses (HP:0003071)1.98973106
111Pancreatic cysts (HP:0001737)1.98140468
112Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.98084064
113CNS demyelination (HP:0007305)1.97569288
114Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96780384
115Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96562474
116Progressive neurologic deterioration (HP:0002344)1.96312524
117Abnormality of the distal phalanges of the toes (HP:0010182)1.96309961
118Abnormality of the duodenum (HP:0002246)1.94985346
119Protrusio acetabuli (HP:0003179)1.94932208
120Increased hepatocellular lipid droplets (HP:0006565)1.94678284
121Hyperphosphaturia (HP:0003109)1.93614971
122Chromsome breakage (HP:0040012)1.93545183
123Microvesicular hepatic steatosis (HP:0001414)1.93151224
124Septo-optic dysplasia (HP:0100842)1.91774271
125Abnormality of the vitamin B12 metabolism (HP:0004341)1.91477938
126Hepatocellular necrosis (HP:0001404)1.91379798
127Abnormality of vitamin B metabolism (HP:0004340)1.91194234
128Disproportionate short-trunk short stature (HP:0003521)1.90218293
129Metaphyseal cupping (HP:0003021)1.89460383
130Large for gestational age (HP:0001520)1.89246293
131Reticulocytopenia (HP:0001896)1.88976534
132Short tibia (HP:0005736)1.88738090
133Absent epiphyses (HP:0010577)1.88340450
134Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.88340450
135Oral leukoplakia (HP:0002745)1.87959033
136Missing ribs (HP:0000921)1.87858349
137Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.87551727
138Triphalangeal thumb (HP:0001199)1.86581782
139Mucopolysacchariduria (HP:0008155)1.85754852
140Urinary glycosaminoglycan excretion (HP:0003541)1.85754852
141Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.84509219
142Abnormality of femoral epiphyses (HP:0006499)1.84509219
143Progressive macrocephaly (HP:0004481)1.83942745
144Abnormality of renal resorption (HP:0011038)1.83134638
145Vertebral hypoplasia (HP:0008417)1.81999445
146Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.81999445
147Abdominal distention (HP:0003270)1.81978913
148Microretrognathia (HP:0000308)1.81859899
149Trismus (HP:0000211)1.81767985
150Biconcave vertebral bodies (HP:0004586)1.81753179
151Abnormalities of placenta or umbilical cord (HP:0001194)1.81590375
152Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.81161276
153Abnormality of midbrain morphology (HP:0002418)1.81051289
154Molar tooth sign on MRI (HP:0002419)1.81051289
155Abnormal umbilical cord blood vessels (HP:0011403)1.80835702
156Single umbilical artery (HP:0001195)1.80835702
157Abnormality of the fetal cardiovascular system (HP:0010948)1.80835702
158Aplasia/hypoplasia of the uterus (HP:0008684)1.80491131
159Glossoptosis (HP:0000162)1.80089575
160Increased intramyocellular lipid droplets (HP:0012240)1.79627747
161Abnormality of the femoral head (HP:0003368)1.78427053
162True hermaphroditism (HP:0010459)1.77369623
163Abnormality of the epiphysis of the femoral head (HP:0010574)1.77171646
164Hypoplasia of the pons (HP:0012110)1.76648909
165Type 2 muscle fiber atrophy (HP:0003554)1.76313001
166Exertional dyspnea (HP:0002875)1.75936514
167Joint stiffness (HP:0001387)1.75215687
168Nausea (HP:0002018)1.75173509
169Abnormal epiphyseal ossification (HP:0010656)1.75085185
170Secondary amenorrhea (HP:0000869)1.74083352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.46586545
2EIF2AK33.81402205
3VRK23.55656969
4NME23.36976489
5STK162.86826765
6NEK12.83617883
7BUB12.66408289
8INSRR2.62163749
9FLT32.59065842
10EIF2AK12.54427068
11TRIM282.41685770
12MAP3K32.34676619
13ERN12.22004794
14MAP3K122.19228610
15TESK11.98622275
16BRSK21.96313044
17BCKDK1.90860543
18VRK11.90798562
19FRK1.87594215
20SRPK11.87245341
21SCYL21.82936340
22MAPK151.82179301
23WEE11.80246794
24PIM21.70047924
25TNIK1.65846833
26PDK21.57592948
27ACVR1B1.53082423
28TESK21.52416273
29MAP4K21.49615598
30MST41.49512596
31TAF11.48199133
32IRAK31.46522087
33PBK1.37430593
34NME11.36409212
35KDR1.32269609
36PIK3CG1.30112926
37LIMK11.29855355
38PLK21.28209242
39HIPK21.27715570
40TEC1.23282700
41BCR1.13657629
42ZAK1.13392578
43IRAK41.13143418
44PLK41.12605185
45BRAF1.10239403
46TAOK31.09966945
47RPS6KA41.09013194
48MAP3K21.04307818
49PRKG21.01568567
50ZAP701.01398853
51ERBB30.99015429
52CDK80.98038595
53EPHA20.95738052
54GRK10.94853203
55STK30.92246037
56DYRK30.90385086
57NLK0.89342649
58CDC70.86631388
59MUSK0.85016272
60TGFBR10.84870707
61ERBB40.83381865
62TLK10.82693073
63PLK30.82551276
64TSSK60.81981874
65WNK30.80656064
66BRSK10.80523475
67OXSR10.79026514
68BTK0.78310476
69CSNK1G10.77862600
70MKNK10.77202816
71EPHA30.75953070
72TIE10.75552416
73PRKCI0.75183030
74STK390.75016904
75CHEK20.74278285
76AURKB0.73339361
77YES10.69969713
78CAMKK20.69544086
79MAP2K20.69257002
80CDK70.68987366
81FGFR10.68417474
82PLK10.68075038
83BMPR1B0.68049472
84AURKA0.67254281
85PAK40.67048944
86JAK30.63300720
87CSNK1G30.63111879
88RPS6KB20.62804785
89MET0.61821906
90EIF2AK20.60993860
91CSNK2A10.60737869
92NEK90.59667673
93DYRK1B0.59254371
94PNCK0.59040236
95ITK0.58329952
96MKNK20.57464649
97NEK20.57081504
98AKT30.56600728
99IRAK10.55004680
100ARAF0.54048164
101CDK190.53589488
102CSNK1G20.53184289
103STK40.51448999
104CSNK2A20.51027167
105ATR0.49929540
106PRKCE0.49812577
107MYLK0.48727402
108LYN0.48716835
109DAPK10.48653709
110UHMK10.48148072
111ATM0.47180999
112MAP3K110.46906686
113ABL20.42221852
114DYRK20.42142774
115LRRK20.42023618
116CCNB10.39691855
117PRKD30.39600893
118PIM10.39214848
119CSNK1A1L0.37676772
120DAPK30.37414705
121ADRBK20.36741736
122NUAK10.36001383
123WNK40.35467713
124TGFBR20.35300893
125CHEK10.34737677
126RPS6KA50.32635623
127STK240.31985364
128CLK10.31405106
129ILK0.31073248
130MAP3K80.30945469
131DDR20.30689409
132PAK30.29626892
133STK38L0.29431823
134ALK0.29097893
135STK100.28822877
136PAK10.27806926
137KIT0.27709939
138CDK30.27697266
139TTK0.27302033
140MAP3K40.27250613
141GRK70.26912492
142PRKCG0.26739580
143ADRBK10.24738792

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030606.96316030
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.83055448
3Proteasome_Homo sapiens_hsa030503.43587433
4Ribosome_Homo sapiens_hsa030103.03643746
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.95636405
6Sulfur metabolism_Homo sapiens_hsa009202.45100654
7DNA replication_Homo sapiens_hsa030302.34305744
8RNA polymerase_Homo sapiens_hsa030202.24770123
9N-Glycan biosynthesis_Homo sapiens_hsa005102.14617168
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.06285144
11Mismatch repair_Homo sapiens_hsa034301.98311901
12Folate biosynthesis_Homo sapiens_hsa007901.93896280
13Pyrimidine metabolism_Homo sapiens_hsa002401.92469761
14Propanoate metabolism_Homo sapiens_hsa006401.89827904
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86642511
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81319908
17Spliceosome_Homo sapiens_hsa030401.70514390
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65565487
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63688929
20Selenocompound metabolism_Homo sapiens_hsa004501.61792985
21Nucleotide excision repair_Homo sapiens_hsa034201.56159925
22Oxidative phosphorylation_Homo sapiens_hsa001901.53362607
23One carbon pool by folate_Homo sapiens_hsa006701.51944730
24Vibrio cholerae infection_Homo sapiens_hsa051101.49462902
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47467379
26Pyruvate metabolism_Homo sapiens_hsa006201.40469834
27RNA transport_Homo sapiens_hsa030131.39095587
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.37397230
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36492293
30Homologous recombination_Homo sapiens_hsa034401.34662006
31Base excision repair_Homo sapiens_hsa034101.34628517
32Other glycan degradation_Homo sapiens_hsa005111.33332705
33Parkinsons disease_Homo sapiens_hsa050121.29249710
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23334233
35Basal transcription factors_Homo sapiens_hsa030221.20344801
36Antigen processing and presentation_Homo sapiens_hsa046121.17946966
37Galactose metabolism_Homo sapiens_hsa000521.14462960
38Non-homologous end-joining_Homo sapiens_hsa034501.13539720
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13018649
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08897189
41RNA degradation_Homo sapiens_hsa030181.06733507
42Purine metabolism_Homo sapiens_hsa002300.97764568
43Legionellosis_Homo sapiens_hsa051340.97321635
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96970155
45Huntingtons disease_Homo sapiens_hsa050160.96317127
46Cell cycle_Homo sapiens_hsa041100.95273696
47Vitamin B6 metabolism_Homo sapiens_hsa007500.91281024
48Type I diabetes mellitus_Homo sapiens_hsa049400.89231081
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88721225
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88510690
51Butanoate metabolism_Homo sapiens_hsa006500.88473436
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87831711
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.87234432
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84551661
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.84174864
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81580634
57Alzheimers disease_Homo sapiens_hsa050100.80481877
58Cardiac muscle contraction_Homo sapiens_hsa042600.80136297
59Lysosome_Homo sapiens_hsa041420.79736843
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75748683
61Regulation of autophagy_Homo sapiens_hsa041400.72448945
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71924305
63Vitamin digestion and absorption_Homo sapiens_hsa049770.71489664
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71280874
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.71089198
66Caffeine metabolism_Homo sapiens_hsa002320.70855318
67Chemical carcinogenesis_Homo sapiens_hsa052040.69461477
68Steroid biosynthesis_Homo sapiens_hsa001000.67727110
69Biosynthesis of amino acids_Homo sapiens_hsa012300.66922935
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66816407
71Fatty acid degradation_Homo sapiens_hsa000710.63666382
72Glutathione metabolism_Homo sapiens_hsa004800.62241785
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61561907
74p53 signaling pathway_Homo sapiens_hsa041150.59148367
75Protein digestion and absorption_Homo sapiens_hsa049740.59102743
76Retinol metabolism_Homo sapiens_hsa008300.59014971
77Metabolic pathways_Homo sapiens_hsa011000.58497576
78Renin-angiotensin system_Homo sapiens_hsa046140.58412971
79Fanconi anemia pathway_Homo sapiens_hsa034600.57867042
80TGF-beta signaling pathway_Homo sapiens_hsa043500.57744740
81Fatty acid elongation_Homo sapiens_hsa000620.57480689
82Epstein-Barr virus infection_Homo sapiens_hsa051690.54868428
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54486971
84Arginine and proline metabolism_Homo sapiens_hsa003300.53505541
85Fatty acid metabolism_Homo sapiens_hsa012120.52036783
86Fructose and mannose metabolism_Homo sapiens_hsa000510.52012814
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50980832
88Sphingolipid metabolism_Homo sapiens_hsa006000.50673397
89Arachidonic acid metabolism_Homo sapiens_hsa005900.50206787
90Phagosome_Homo sapiens_hsa041450.50016688
91Starch and sucrose metabolism_Homo sapiens_hsa005000.48184990
92Nitrogen metabolism_Homo sapiens_hsa009100.45966948
93Oocyte meiosis_Homo sapiens_hsa041140.44147376
94Sulfur relay system_Homo sapiens_hsa041220.43307850
95Systemic lupus erythematosus_Homo sapiens_hsa053220.42484396
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41650272
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39839013
98Pentose phosphate pathway_Homo sapiens_hsa000300.39605948
99Thyroid cancer_Homo sapiens_hsa052160.39068008
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38817388
101Fat digestion and absorption_Homo sapiens_hsa049750.38329453
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.36645809
103beta-Alanine metabolism_Homo sapiens_hsa004100.36019749
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35856631
105Phototransduction_Homo sapiens_hsa047440.33368950
106Histidine metabolism_Homo sapiens_hsa003400.31826814
107Linoleic acid metabolism_Homo sapiens_hsa005910.31816203
108Basal cell carcinoma_Homo sapiens_hsa052170.31168474
109Viral carcinogenesis_Homo sapiens_hsa052030.31025862
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29902876
111Herpes simplex infection_Homo sapiens_hsa051680.29876264
112Collecting duct acid secretion_Homo sapiens_hsa049660.28553459
113Asthma_Homo sapiens_hsa053100.27831187
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26631152
115Hedgehog signaling pathway_Homo sapiens_hsa043400.25256698
116mRNA surveillance pathway_Homo sapiens_hsa030150.25098737
117Mineral absorption_Homo sapiens_hsa049780.24476863
118Tyrosine metabolism_Homo sapiens_hsa003500.24449573
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24375564
120Tryptophan metabolism_Homo sapiens_hsa003800.23637616
121Insulin secretion_Homo sapiens_hsa049110.22181474
122Phenylalanine metabolism_Homo sapiens_hsa003600.21099103
123Thyroid hormone synthesis_Homo sapiens_hsa049180.20877193
124Alcoholism_Homo sapiens_hsa050340.20256067
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19559141
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18760772
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18508139
128Hematopoietic cell lineage_Homo sapiens_hsa046400.17148722
129ECM-receptor interaction_Homo sapiens_hsa045120.16886497
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.13613789
131Apoptosis_Homo sapiens_hsa042100.13285532
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.11885429
133Peroxisome_Homo sapiens_hsa041460.11109150
134Carbon metabolism_Homo sapiens_hsa012000.10797277
135Malaria_Homo sapiens_hsa051440.10665868

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