OSTCP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.69689784
2positive regulation of interleukin-17 production (GO:0032740)5.63432317
3regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.17439216
4DNA deamination (GO:0045006)5.09110577
5respiratory chain complex IV assembly (GO:0008535)4.40870988
6RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.27770635
7regulation of isotype switching to IgG isotypes (GO:0048302)4.27192190
8proteasome assembly (GO:0043248)4.26558352
9regulation of regulatory T cell differentiation (GO:0045589)4.25961766
10regulation of immunoglobulin secretion (GO:0051023)4.19882550
11positive regulation of DNA recombination (GO:0045911)4.00340498
12positive regulation of isotype switching (GO:0045830)3.96068910
13regulation of B cell apoptotic process (GO:0002902)3.68254711
14negative regulation of B cell apoptotic process (GO:0002903)3.63842466
15cytochrome complex assembly (GO:0017004)3.61217123
16DNA double-strand break processing (GO:0000729)3.53335170
17indole-containing compound catabolic process (GO:0042436)3.46719547
18indolalkylamine catabolic process (GO:0046218)3.46719547
19tryptophan catabolic process (GO:0006569)3.46719547
20somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.46705951
21somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.46705951
22isotype switching (GO:0045190)3.46705951
23negative regulation of T-helper cell differentiation (GO:0045623)3.36631592
24negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.36631592
25tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.34943061
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.34943061
27response to pheromone (GO:0019236)3.26735502
28immunoglobulin mediated immune response (GO:0016064)3.24843892
29regulation of chronic inflammatory response (GO:0002676)3.24207070
30maturation of 5.8S rRNA (GO:0000460)3.16610342
31positive regulation of immunoglobulin mediated immune response (GO:0002891)3.12527705
32positive regulation of B cell mediated immunity (GO:0002714)3.12527705
33positive regulation of granulocyte differentiation (GO:0030854)3.12058347
34positive regulation of natural killer cell differentiation (GO:0032825)3.11856497
35pseudouridine synthesis (GO:0001522)3.07794101
36prenylation (GO:0097354)3.07501898
37protein prenylation (GO:0018342)3.07501898
38RNA phosphodiester bond hydrolysis (GO:0090501)3.06116602
39kynurenine metabolic process (GO:0070189)3.04160697
40B cell mediated immunity (GO:0019724)3.01678553
41regulation of interleukin-17 production (GO:0032660)2.99430346
42positive regulation of activated T cell proliferation (GO:0042104)2.98695245
43DNA catabolic process, exonucleolytic (GO:0000738)2.95626556
44positive regulation of interleukin-10 production (GO:0032733)2.94271529
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92761556
46negative regulation of alpha-beta T cell differentiation (GO:0046639)2.89925939
47tryptophan metabolic process (GO:0006568)2.89274667
48hepatocyte apoptotic process (GO:0097284)2.87671674
49neutrophil activation involved in immune response (GO:0002283)2.85793813
50cell wall macromolecule catabolic process (GO:0016998)2.85063842
51ATP synthesis coupled proton transport (GO:0015986)2.84058119
52energy coupled proton transport, down electrochemical gradient (GO:0015985)2.84058119
53natural killer cell activation (GO:0030101)2.82364846
54gonadal mesoderm development (GO:0007506)2.82075488
55positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.79453532
56positive regulation of alpha-beta T cell proliferation (GO:0046641)2.79035633
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.76276895
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.73303971
59production of molecular mediator of immune response (GO:0002440)2.72444459
60cell wall macromolecule metabolic process (GO:0044036)2.72135444
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.70836454
62CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.70591240
63positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.69953713
64base-excision repair, AP site formation (GO:0006285)2.69942277
65positive regulation of immunoglobulin production (GO:0002639)2.69345650
66platelet dense granule organization (GO:0060155)2.68295763
67regulation of isotype switching (GO:0045191)2.67076664
68regulation of thymocyte apoptotic process (GO:0070243)2.63854767
69embryonic hemopoiesis (GO:0035162)2.63731937
70neural tube formation (GO:0001841)2.59896091
71indolalkylamine metabolic process (GO:0006586)2.59848236
72negative regulation of acute inflammatory response (GO:0002674)2.55841469
73somatic recombination of immunoglobulin gene segments (GO:0016447)2.54940443
74synapsis (GO:0007129)2.53366348
75regulation of memory T cell differentiation (GO:0043380)2.53267891
76tRNA processing (GO:0008033)2.53078130
77double-strand break repair via homologous recombination (GO:0000724)2.52520175
78somatic diversification of immunoglobulins (GO:0016445)2.50445173
79regulation of germinal center formation (GO:0002634)2.50442976
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.50012839
81purine deoxyribonucleotide catabolic process (GO:0009155)2.49772239
82positive regulation of mitotic sister chromatid separation (GO:1901970)2.49671020
83positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.49671020
84positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.49671020
85nucleotide transmembrane transport (GO:1901679)2.48068361
86mucosal-associated lymphoid tissue development (GO:0048537)2.47663506
87Peyers patch development (GO:0048541)2.47663506
88recombinational repair (GO:0000725)2.47430068
89regulation of T-helper cell differentiation (GO:0045622)2.46977821
90positive regulation of interferon-gamma production (GO:0032729)2.46541757
91GTP biosynthetic process (GO:0006183)2.44938184
92positive regulation of B cell proliferation (GO:0030890)2.44561494
93establishment of protein localization to mitochondrial membrane (GO:0090151)2.43618557
94protein complex biogenesis (GO:0070271)2.43068698
95regulation of hypersensitivity (GO:0002883)2.40236684
96regulation of activated T cell proliferation (GO:0046006)2.40226369
97regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.40154344
98replication fork processing (GO:0031297)2.40013739
99positive regulation of tissue remodeling (GO:0034105)2.39847503
100regulation of immunoglobulin production (GO:0002637)2.39588802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.32256943
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.20363124
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.92586747
4TAF15_26573619_Chip-Seq_HEK293_Human2.92325599
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.92301673
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.82685407
7VDR_22108803_ChIP-Seq_LS180_Human2.81871111
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.72808662
9ZNF274_21170338_ChIP-Seq_K562_Hela2.71070350
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.69673598
11ELK1_19687146_ChIP-ChIP_HELA_Human2.61346791
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.60881893
13VDR_23849224_ChIP-Seq_CD4+_Human2.44332891
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.44047913
15EWS_26573619_Chip-Seq_HEK293_Human2.27653133
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26929781
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16624491
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.11255893
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10834163
20FUS_26573619_Chip-Seq_HEK293_Human1.96239026
21E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95828657
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95420507
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94433689
24PADI4_21655091_ChIP-ChIP_MCF-7_Human1.75217833
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71517351
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69305662
27P300_19829295_ChIP-Seq_ESCs_Human1.62641995
28FOXP3_21729870_ChIP-Seq_TREG_Human1.61675432
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60650787
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60484113
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57918711
32GATA3_26560356_Chip-Seq_TH2_Human1.56982325
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.56623401
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54887098
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54565516
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53896779
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.52787629
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49027992
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46804479
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46455372
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46204502
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42469608
43ER_23166858_ChIP-Seq_MCF-7_Human1.42357355
44TP53_22573176_ChIP-Seq_HFKS_Human1.42060414
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.39205798
46MYC_18940864_ChIP-ChIP_HL60_Human1.39142530
47NANOG_19829295_ChIP-Seq_ESCs_Human1.38381403
48SOX2_19829295_ChIP-Seq_ESCs_Human1.38381403
49CBP_20019798_ChIP-Seq_JUKART_Human1.38176654
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38176654
51AUTS2_25519132_ChIP-Seq_293T-REX_Human1.36662730
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36649841
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36507482
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33863530
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.33044658
56GBX2_23144817_ChIP-Seq_PC3_Human1.29343833
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.28861643
58BCAT_22108803_ChIP-Seq_LS180_Human1.24117283
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23026773
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.22803192
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22554815
62CDX2_22108803_ChIP-Seq_LS180_Human1.21060386
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20315622
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.19946011
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.14064389
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14064389
67STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13770254
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13487867
69MYB_26560356_Chip-Seq_TH2_Human1.10722866
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10420054
71PHF8_20622853_ChIP-Seq_HELA_Human1.09141249
72PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08970443
73SALL4_22934838_ChIP-ChIP_CD34+_Human1.08656766
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07982940
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07376108
76TCF4_22108803_ChIP-Seq_LS180_Human1.07214431
77GATA3_27048872_Chip-Seq_THYMUS_Human1.06575528
78RBPJ_21746931_ChIP-Seq_IB4_Human1.05604921
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05357197
80ETV1_20927104_ChIP-Seq_GIST48_Human1.03697037
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03225829
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.03139178
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02688051
84GATA6_21074721_ChIP-Seq_CACO-2_Human1.02486779
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00884692
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98423927
87CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98214975
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.98097201
89SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96621322
90E2F1_18555785_Chip-Seq_ESCs_Mouse0.96562508
91NFYB_21822215_ChIP-Seq_K562_Human0.96456619
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95823542
93PRDM14_20953172_ChIP-Seq_ESCs_Human0.95793967
94P300_18555785_Chip-Seq_ESCs_Mouse0.95774768
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95471138
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95391752
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.95336445
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95311375
99HNFA_21074721_ChIP-Seq_CACO-2_Human0.95138911
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94893080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.75228494
2MP0002138_abnormal_hepatobiliary_system3.46947326
3MP0000569_abnormal_digit_pigmentation3.36538679
4MP0004147_increased_porphyrin_level2.99155213
5MP0002837_dystrophic_cardiac_calcinosis2.47015248
6MP0005360_urolithiasis2.45047152
7MP0008877_abnormal_DNA_methylation2.36685621
8MP0002102_abnormal_ear_morphology2.28435920
9MP0002638_abnormal_pupillary_reflex2.11290390
10MP0008057_abnormal_DNA_replication2.10164243
11MP0005671_abnormal_response_to2.06608071
12MP0001873_stomach_inflammation2.04869335
13MP0002009_preneoplasia2.01556701
14MP0008872_abnormal_physiological_respon2.00575469
15MP0003252_abnormal_bile_duct1.99106788
16MP0002163_abnormal_gland_morphology1.95390540
17MP0006292_abnormal_olfactory_placode1.89972962
18MP0005379_endocrine/exocrine_gland_phen1.89920429
19MP0002166_altered_tumor_susceptibility1.82849202
20MP0003195_calcinosis1.80807476
21MP0003300_gastrointestinal_ulcer1.78239692
22MP0000372_irregular_coat_pigmentation1.77805984
23MP0005075_abnormal_melanosome_morpholog1.68281276
24MP0002396_abnormal_hematopoietic_system1.66971087
25MP0003567_abnormal_fetal_cardiomyocyte1.66661489
26MP0001348_abnormal_lacrimal_gland1.66175201
27MP0002148_abnormal_hypersensitivity_rea1.65613939
28MP0001853_heart_inflammation1.64046893
29MP0001800_abnormal_humoral_immune1.63765716
30MP0009333_abnormal_splenocyte_physiolog1.63215731
31MP0006072_abnormal_retinal_apoptosis1.60642735
32MP0005084_abnormal_gallbladder_morpholo1.55881161
33MP0008995_early_reproductive_senescence1.49573392
34MP0004043_abnormal_pH_regulation1.47744131
35MP0005000_abnormal_immune_tolerance1.46888692
36MP0006082_CNS_inflammation1.42617734
37MP0002006_tumorigenesis1.42082560
38MP0003786_premature_aging1.39161399
39MP0000465_gastrointestinal_hemorrhage1.38225470
40MP0003806_abnormal_nucleotide_metabolis1.38007575
41MP0001661_extended_life_span1.36037494
42MP0000427_abnormal_hair_cycle1.33178388
43MP0008775_abnormal_heart_ventricle1.31835188
44MP0005551_abnormal_eye_electrophysiolog1.31272906
45MP0003718_maternal_effect1.28971986
46MP0004145_abnormal_muscle_electrophysio1.28915854
47MP0001790_abnormal_immune_system1.28453844
48MP0005387_immune_system_phenotype1.28453844
49MP0005253_abnormal_eye_physiology1.26601715
50MP0005408_hypopigmentation1.25937443
51MP0000685_abnormal_immune_system1.24934471
52MP0010094_abnormal_chromosome_stability1.22980978
53MP0004084_abnormal_cardiac_muscle1.22719789
54MP0002928_abnormal_bile_duct1.20848183
55MP0003950_abnormal_plasma_membrane1.20293552
56MP0000383_abnormal_hair_follicle1.15641207
57MP0005174_abnormal_tail_pigmentation1.15427168
58MP0010678_abnormal_skin_adnexa1.13487960
59MP0006036_abnormal_mitochondrial_physio1.13258353
60MP0004782_abnormal_surfactant_physiolog1.10832971
61MP0006054_spinal_hemorrhage1.10214092
62MP0000604_amyloidosis1.08951349
63MP0001968_abnormal_touch/_nociception1.06309810
64MP0000647_abnormal_sebaceous_gland1.05095073
65MP0002723_abnormal_immune_serum1.04920854
66MP0004381_abnormal_hair_follicle1.04448233
67MP0002452_abnormal_antigen_presenting1.01984787
68MP0000538_abnormal_urinary_bladder1.01802533
69MP0008875_abnormal_xenobiotic_pharmacok1.01386660
70MP0009785_altered_susceptibility_to1.01381286
71MP0002095_abnormal_skin_pigmentation1.01136864
72MP0003656_abnormal_erythrocyte_physiolo0.99816499
73MP0002139_abnormal_hepatobiliary_system0.99146984
74MP0008058_abnormal_DNA_repair0.98829422
75MP0004134_abnormal_chest_morphology0.97297804
76MP0001986_abnormal_taste_sensitivity0.97138469
77MP0009697_abnormal_copulation0.94194896
78MP0004215_abnormal_myocardial_fiber0.90862317
79MP0009764_decreased_sensitivity_to0.90786998
80MP0002938_white_spotting0.90505886
81MP0002398_abnormal_bone_marrow0.90251642
82MP0000689_abnormal_spleen_morphology0.87319845
83MP0002420_abnormal_adaptive_immunity0.86219425
84MP0005085_abnormal_gallbladder_physiolo0.83690115
85MP0002693_abnormal_pancreas_physiology0.83256333
86MP0010329_abnormal_lipoprotein_level0.81555593
87MP0005367_renal/urinary_system_phenotyp0.81098473
88MP0000516_abnormal_urinary_system0.81098473
89MP0004142_abnormal_muscle_tone0.79649278
90MP0009046_muscle_twitch0.79006675
91MP0001819_abnormal_immune_cell0.78404059
92MP0001293_anophthalmia0.75633666
93MP0002234_abnormal_pharynx_morphology0.72510736
94MP0001845_abnormal_inflammatory_respons0.72496424
95MP0010386_abnormal_urinary_bladder0.70832004
96MP0004957_abnormal_blastocyst_morpholog0.70395912
97MP0000716_abnormal_immune_system0.68595898
98MP0002405_respiratory_system_inflammati0.68478633
99MP0005410_abnormal_fertilization0.66751890
100MP0001501_abnormal_sleep_pattern0.66334316

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)3.82319373
2Acute necrotizing encephalopathy (HP:0006965)3.51608030
3True hermaphroditism (HP:0010459)3.43076387
4Increased CSF lactate (HP:0002490)3.40705398
5Absent rod-and cone-mediated responses on ERG (HP:0007688)3.39515088
6Pancreatic cysts (HP:0001737)3.39232429
7Abnormal biliary tract physiology (HP:0012439)3.38691121
8Bile duct proliferation (HP:0001408)3.38691121
9Acute encephalopathy (HP:0006846)3.38448730
10Congenital, generalized hypertrichosis (HP:0004540)3.37932995
11Abnormality of the prostate (HP:0008775)3.33072579
12Abnormal rod and cone electroretinograms (HP:0008323)3.33025329
13Congenital stationary night blindness (HP:0007642)3.24521742
14Progressive macrocephaly (HP:0004481)3.19379141
15Pancreatic fibrosis (HP:0100732)3.17803580
16Renal cortical cysts (HP:0000803)3.06870740
17Volvulus (HP:0002580)3.03761522
18Mitochondrial inheritance (HP:0001427)2.95161003
19Abnormality of B cell number (HP:0010975)2.85404182
20Abnormal mitochondria in muscle tissue (HP:0008316)2.80985633
21B lymphocytopenia (HP:0010976)2.79616645
22Nephronophthisis (HP:0000090)2.77405338
23Abnormality of the renal cortex (HP:0011035)2.74183809
24Aplastic anemia (HP:0001915)2.71245488
25Elevated erythrocyte sedimentation rate (HP:0003565)2.70862544
26Dyschromatopsia (HP:0007641)2.51044545
27Hepatic necrosis (HP:0002605)2.50397836
28Prostate neoplasm (HP:0100787)2.47587209
29Chronic diarrhea (HP:0002028)2.44175587
30Abnormality of T cell physiology (HP:0011840)2.44060033
31IgG deficiency (HP:0004315)2.43981618
32Abnormality of male internal genitalia (HP:0000022)2.41115634
33Asplenia (HP:0001746)2.40794414
34Progressive inability to walk (HP:0002505)2.40513587
35Abnormality of the renal medulla (HP:0100957)2.40243182
36Chromsome breakage (HP:0040012)2.36245406
37Severe muscular hypotonia (HP:0006829)2.34447682
38Constricted visual fields (HP:0001133)2.33861782
39Abnormality of alanine metabolism (HP:0010916)2.31431714
40Hyperalaninemia (HP:0003348)2.31431714
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.31431714
42Hypothermia (HP:0002045)2.31097826
43Abnormality of T cells (HP:0002843)2.27301464
44Attenuation of retinal blood vessels (HP:0007843)2.27185352
45Hepatocellular necrosis (HP:0001404)2.26646916
463-Methylglutaconic aciduria (HP:0003535)2.26630290
47Increased IgM level (HP:0003496)2.25379517
48Increased serum lactate (HP:0002151)2.21535828
49Cerebral edema (HP:0002181)2.21341648
50Severe combined immunodeficiency (HP:0004430)2.20140149
51Inability to walk (HP:0002540)2.19094774
52Autoimmune hemolytic anemia (HP:0001890)2.17575740
53Chronic hepatic failure (HP:0100626)2.16503482
54Aplasia/Hypoplasia of the spleen (HP:0010451)2.16497241
55Molar tooth sign on MRI (HP:0002419)2.16172892
56Abnormality of midbrain morphology (HP:0002418)2.16172892
57Colon cancer (HP:0003003)2.14079240
58Cystic liver disease (HP:0006706)2.11499101
59Abnormality of chromosome stability (HP:0003220)2.11321536
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.11139738
61Thyroiditis (HP:0100646)2.09531441
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03621618
63Optic disc pallor (HP:0000543)2.02464804
64Progressive microcephaly (HP:0000253)2.02068088
65Poor head control (HP:0002421)2.02054954
66Supernumerary spleens (HP:0009799)2.01186262
67Abolished electroretinogram (ERG) (HP:0000550)1.99151473
68Hematochezia (HP:0002573)1.94824821
69Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91405903
70Leukodystrophy (HP:0002415)1.91027068
71Lactic acidosis (HP:0003128)1.90058435
72Fatigue (HP:0012378)1.89858186
73Tongue fasciculations (HP:0001308)1.89093978
74Panhypogammaglobulinemia (HP:0003139)1.88424876
75Generalized aminoaciduria (HP:0002909)1.88171819
76Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.86847591
77Abnormality of T cell number (HP:0011839)1.86345568
78Combined immunodeficiency (HP:0005387)1.84958184
79Abnormality of the ileum (HP:0001549)1.83705982
80Fair hair (HP:0002286)1.82852065
81Aplasia/Hypoplasia of the uvula (HP:0010293)1.82464173
82T lymphocytopenia (HP:0005403)1.81807793
83Sclerocornea (HP:0000647)1.81279008
84Clubbing of toes (HP:0100760)1.80061771
85Furrowed tongue (HP:0000221)1.77402449
86Abnormality of the phalanges of the 5th finger (HP:0004213)1.76005489
87Male pseudohermaphroditism (HP:0000037)1.75025906
88Meckel diverticulum (HP:0002245)1.74168415
89Tubulointerstitial nephritis (HP:0001970)1.74018933
90Sensory axonal neuropathy (HP:0003390)1.72302292
91Aplasia/Hypoplasia of the tibia (HP:0005772)1.72292030
92Small hand (HP:0200055)1.71667244
93Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71126997
94Type II lissencephaly (HP:0007260)1.70044909
95Abnormality of serum amino acid levels (HP:0003112)1.69603090
96Limb hypertonia (HP:0002509)1.69295401
97Ependymoma (HP:0002888)1.69278963
98Arthropathy (HP:0003040)1.68763597
99Anencephaly (HP:0002323)1.68157213
100Abnormality of the preputium (HP:0100587)1.67942961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.95452022
2TRIM282.91365613
3MKNK22.87122568
4EIF2AK32.73911560
5MST42.61913038
6TAOK32.61800770
7SIK32.57002345
8EIF2AK12.36175943
9BMPR22.25520881
10BMPR1B2.10932797
11MKNK11.98301141
12ACVR1B1.93608127
13TEC1.86706001
14TSSK61.85463263
15ERBB31.79518933
16MAP3K121.71544366
17ADRBK21.68425711
18NEK11.65159331
19STK391.59365410
20WNK41.53164139
21NUAK11.52261124
22GRK11.51283850
23PLK41.42674512
24WNK31.37422178
25OXSR11.36539369
26STK161.36364263
27PIK3CG1.36132145
28MAP3K141.34989827
29BRSK21.31222105
30PLK31.29395542
31PBK1.22897547
32TRPM71.22658533
33SIK21.20429435
34PHKG11.17322958
35PHKG21.17322958
36CDK81.17270569
37BRD41.13668083
38BUB11.10994619
39ZAK1.10268732
40RIPK41.09108266
41PLK21.08954494
42ITK1.06106365
43IKBKB1.03818474
44TGFBR10.98572713
45RPS6KA40.97338259
46MAP4K20.91475199
47SYK0.86324533
48WEE10.84423603
49STK30.82847664
50MAP3K40.82641189
51BLK0.81417893
52LYN0.80402609
53TNIK0.80278061
54MARK30.78789808
55ATR0.75962977
56SRPK10.73939252
57PTK2B0.73835596
58DAPK10.73071452
59TLK10.72695899
60TTK0.71329212
61VRK10.69565450
62WNK10.69220980
63BCR0.68416267
64PDK20.67818081
65MAPK130.66340266
66PINK10.63655896
67PRKCE0.62398230
68IGF1R0.62022071
69PRKCQ0.61908630
70TYK20.60899276
71VRK20.59575309
72PAK30.58625450
73MYLK0.57280993
74KIT0.54638249
75FLT30.54201366
76BTK0.52270089
77ABL10.52174247
78LCK0.51152701
79IKBKE0.48908233
80RPS6KA50.48812661
81EIF2AK20.47315701
82PASK0.47131837
83PLK10.46929083
84MAPKAPK30.46469683
85ATM0.45662105
86CCNB10.44220792
87CSNK2A20.44032760
88PRKCG0.44032401
89EGFR0.43985007
90HCK0.43116982
91TXK0.42978936
92STK38L0.42445701
93OBSCN0.41426760
94GRK60.40136482
95MAPK110.39724305
96TNK20.39240508
97JAK30.38608535
98PNCK0.37006012
99FGFR10.36280691
100PRKG10.35227198

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.68184417
2Allograft rejection_Homo sapiens_hsa053304.42745061
3Autoimmune thyroid disease_Homo sapiens_hsa053204.29327491
4Intestinal immune network for IgA production_Homo sapiens_hsa046724.14610968
5Type I diabetes mellitus_Homo sapiens_hsa049403.53239552
6Graft-versus-host disease_Homo sapiens_hsa053323.44834974
7Proteasome_Homo sapiens_hsa030502.78341542
8Protein export_Homo sapiens_hsa030602.57168729
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.53958640
10One carbon pool by folate_Homo sapiens_hsa006702.34292629
11Homologous recombination_Homo sapiens_hsa034402.13448706
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06109853
13Nitrogen metabolism_Homo sapiens_hsa009101.80663832
14Oxidative phosphorylation_Homo sapiens_hsa001901.74719097
15Rheumatoid arthritis_Homo sapiens_hsa053231.70382435
16RNA degradation_Homo sapiens_hsa030181.70334405
17Viral myocarditis_Homo sapiens_hsa054161.69432086
18Primary immunodeficiency_Homo sapiens_hsa053401.59235441
19Antigen processing and presentation_Homo sapiens_hsa046121.54201571
20Staphylococcus aureus infection_Homo sapiens_hsa051501.54044439
21Hematopoietic cell lineage_Homo sapiens_hsa046401.50593683
22Parkinsons disease_Homo sapiens_hsa050121.49047552
23Basal transcription factors_Homo sapiens_hsa030221.43775643
24RNA transport_Homo sapiens_hsa030131.38220532
25Phototransduction_Homo sapiens_hsa047441.31042452
26Fanconi anemia pathway_Homo sapiens_hsa034601.24382396
27Selenocompound metabolism_Homo sapiens_hsa004501.23276840
28Ribosome_Homo sapiens_hsa030101.21322261
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20825746
30RNA polymerase_Homo sapiens_hsa030201.12520019
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03228811
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02862328
33Olfactory transduction_Homo sapiens_hsa047401.02746095
34Butanoate metabolism_Homo sapiens_hsa006500.99841930
35Leishmaniasis_Homo sapiens_hsa051400.99027869
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98018707
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96126526
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95107463
39NF-kappa B signaling pathway_Homo sapiens_hsa040640.88755618
40Propanoate metabolism_Homo sapiens_hsa006400.88084211
41Base excision repair_Homo sapiens_hsa034100.87821988
42Non-homologous end-joining_Homo sapiens_hsa034500.87339742
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84631284
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81271069
45Alzheimers disease_Homo sapiens_hsa050100.80709425
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.76150166
47Systemic lupus erythematosus_Homo sapiens_hsa053220.73391249
48Huntingtons disease_Homo sapiens_hsa050160.72759914
49Herpes simplex infection_Homo sapiens_hsa051680.72524666
50Tryptophan metabolism_Homo sapiens_hsa003800.72018758
51Legionellosis_Homo sapiens_hsa051340.70910019
52T cell receptor signaling pathway_Homo sapiens_hsa046600.69597580
53Linoleic acid metabolism_Homo sapiens_hsa005910.68850444
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67220478
55Spliceosome_Homo sapiens_hsa030400.66351031
56Pyrimidine metabolism_Homo sapiens_hsa002400.63900197
57Regulation of autophagy_Homo sapiens_hsa041400.57163125
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54497397
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53256513
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.52369956
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52344215
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51890806
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51018403
64Mismatch repair_Homo sapiens_hsa034300.50056806
65Caffeine metabolism_Homo sapiens_hsa002320.47577076
66Purine metabolism_Homo sapiens_hsa002300.46444121
67Sulfur metabolism_Homo sapiens_hsa009200.46428797
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41675199
69Fat digestion and absorption_Homo sapiens_hsa049750.40973533
70Peroxisome_Homo sapiens_hsa041460.40799450
71Measles_Homo sapiens_hsa051620.40569808
72Taste transduction_Homo sapiens_hsa047420.39094287
73Tuberculosis_Homo sapiens_hsa051520.38235337
74Toxoplasmosis_Homo sapiens_hsa051450.35938458
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32668980
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30095830
77Ether lipid metabolism_Homo sapiens_hsa005650.29885660
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29342299
79Cardiac muscle contraction_Homo sapiens_hsa042600.28202092
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27420934
81Nucleotide excision repair_Homo sapiens_hsa034200.26722537
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26122962
83Glutathione metabolism_Homo sapiens_hsa004800.25746607
84Steroid biosynthesis_Homo sapiens_hsa001000.25579755
85Mineral absorption_Homo sapiens_hsa049780.23769483
86Arachidonic acid metabolism_Homo sapiens_hsa005900.23747452
87Influenza A_Homo sapiens_hsa051640.23640918
88p53 signaling pathway_Homo sapiens_hsa041150.21638213
89Collecting duct acid secretion_Homo sapiens_hsa049660.21472275
90DNA replication_Homo sapiens_hsa030300.20955890
91Metabolic pathways_Homo sapiens_hsa011000.20866920
92Epstein-Barr virus infection_Homo sapiens_hsa051690.19364636
93HTLV-I infection_Homo sapiens_hsa051660.19339060
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.17643348
95Salivary secretion_Homo sapiens_hsa049700.17570894
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.14494964
97Chemical carcinogenesis_Homo sapiens_hsa052040.14213660
98Circadian rhythm_Homo sapiens_hsa047100.13727607
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13117403
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.11302911

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