OSTCP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)8.80195393
2regulation of isotype switching to IgG isotypes (GO:0048302)7.83451444
3regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)7.60549230
4regulation of immunoglobulin secretion (GO:0051023)6.16387303
5chaperone-mediated protein transport (GO:0072321)6.00830017
6negative regulation of B cell apoptotic process (GO:0002903)5.66447169
7positive regulation of isotype switching (GO:0045830)5.62927145
8positive regulation of interleukin-17 production (GO:0032740)5.49374590
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.30687802
10regulation of regulatory T cell differentiation (GO:0045589)5.07036589
11positive regulation of DNA recombination (GO:0045911)5.05600095
12positive regulation of activated T cell proliferation (GO:0042104)5.01351344
13kynurenine metabolic process (GO:0070189)4.94420310
14ATP synthesis coupled proton transport (GO:0015986)4.93073573
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.93073573
16negative regulation of T-helper cell differentiation (GO:0045623)4.62778514
17negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.62778514
18indole-containing compound catabolic process (GO:0042436)4.50140035
19indolalkylamine catabolic process (GO:0046218)4.50140035
20tryptophan catabolic process (GO:0006569)4.50140035
21respiratory chain complex IV assembly (GO:0008535)4.46913504
22activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.37487091
23ribosomal small subunit assembly (GO:0000028)4.35836308
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.29675494
25tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.29675494
26regulation of podosome assembly (GO:0071801)4.22613825
27regulation of B cell apoptotic process (GO:0002902)4.14706498
28glycerophospholipid catabolic process (GO:0046475)4.03115468
29regulation of activated T cell proliferation (GO:0046006)4.00103991
30positive regulation of immunoglobulin mediated immune response (GO:0002891)3.92252073
31positive regulation of B cell mediated immunity (GO:0002714)3.92252073
32proteasome assembly (GO:0043248)3.90551906
33regulation of helicase activity (GO:0051095)3.89171877
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.80515182
35positive regulation of immunoglobulin production (GO:0002639)3.79846237
36tryptophan metabolic process (GO:0006568)3.79426381
37negative regulation of alpha-beta T cell differentiation (GO:0046639)3.78012285
38negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.73084469
39regulation of isotype switching (GO:0045191)3.71006979
40cytochrome complex assembly (GO:0017004)3.67476083
41mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.65450237
42respiratory electron transport chain (GO:0022904)3.56371969
43electron transport chain (GO:0022900)3.56246852
44regulation of chronic inflammatory response (GO:0002676)3.53905831
45cellular biogenic amine catabolic process (GO:0042402)3.51349261
46amine catabolic process (GO:0009310)3.51349261
47negative regulation of acute inflammatory response (GO:0002674)3.44906780
48indolalkylamine metabolic process (GO:0006586)3.39793065
49purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.32010529
50protein complex biogenesis (GO:0070271)3.30115481
51cellular response to exogenous dsRNA (GO:0071360)3.29055535
52pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.28755598
53regulation of hypersensitivity (GO:0002883)3.21297176
54platelet dense granule organization (GO:0060155)3.16264145
55nucleotide transmembrane transport (GO:1901679)3.16058642
56viral transcription (GO:0019083)3.14326550
57SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14254077
58pseudouridine synthesis (GO:0001522)3.09011615
59cotranslational protein targeting to membrane (GO:0006613)3.07836091
60regulation of T-helper cell differentiation (GO:0045622)3.03627380
61protein targeting to ER (GO:0045047)3.03556338
62dopamine transport (GO:0015872)3.03483000
63positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.02561572
64ribosomal large subunit biogenesis (GO:0042273)3.02555774
65translational termination (GO:0006415)3.02126078
66mitochondrial respiratory chain complex assembly (GO:0033108)3.01666165
67establishment of protein localization to endoplasmic reticulum (GO:0072599)3.00045514
68hydrogen ion transmembrane transport (GO:1902600)2.96144189
69regulation of interleukin-17 production (GO:0032660)2.91417067
70RNA phosphodiester bond hydrolysis (GO:0090501)2.89025011
71protein localization to endoplasmic reticulum (GO:0070972)2.88827168
72positive regulation of B cell proliferation (GO:0030890)2.88617114
73translation (GO:0006412)2.88513096
74positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.88138029
75regulation of immunoglobulin production (GO:0002637)2.84101905
76rRNA modification (GO:0000154)2.81416224
77nucleotide-excision repair, DNA gap filling (GO:0006297)2.81295302
78pyrimidine nucleotide catabolic process (GO:0006244)2.80452938
79ATP biosynthetic process (GO:0006754)2.78656071
80proton transport (GO:0015992)2.78558890
81regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.78196119
82DNA deamination (GO:0045006)2.76099923
83positive regulation of granulocyte differentiation (GO:0030854)2.75081817
84positive regulation of toll-like receptor signaling pathway (GO:0034123)2.74771062
85hydrogen transport (GO:0006818)2.73800346
86translational elongation (GO:0006414)2.72053288
87regulation of immunoglobulin mediated immune response (GO:0002889)2.69392735
88positive regulation of dendritic spine development (GO:0060999)2.68596070
89positive regulation of JAK-STAT cascade (GO:0046427)2.67916910
90base-excision repair, AP site formation (GO:0006285)2.67735630
91negative regulation of heart contraction (GO:0045822)2.67526113
92positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.67181991
93viral life cycle (GO:0019058)2.66874699
94purine nucleoside triphosphate biosynthetic process (GO:0009145)2.66148320
95intracellular protein transmembrane import (GO:0044743)2.65804503
96CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.65661409
97T-helper cell differentiation (GO:0042093)2.65661409
98negative regulation of chemokine production (GO:0032682)2.64365207
99NADH dehydrogenase complex assembly (GO:0010257)2.64185156
100mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64185156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.50087481
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.10784218
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.03025493
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.67235629
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.52348658
6ZNF274_21170338_ChIP-Seq_K562_Hela3.18068957
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.17675171
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.16142591
9TAF15_26573619_Chip-Seq_HEK293_Human3.01963566
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.99304738
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.60060692
12VDR_23849224_ChIP-Seq_CD4+_Human2.44620163
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41191966
14FUS_26573619_Chip-Seq_HEK293_Human2.26996322
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.25121120
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10122665
17YY1_21170310_ChIP-Seq_MESCs_Mouse2.09190874
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.06864629
19EZH2_22144423_ChIP-Seq_EOC_Human1.92980113
20MYC_18940864_ChIP-ChIP_HL60_Human1.87691651
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.86334670
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.84194307
23ELK1_19687146_ChIP-ChIP_HELA_Human1.83553981
24FOXP3_21729870_ChIP-Seq_TREG_Human1.81096770
25EWS_26573619_Chip-Seq_HEK293_Human1.80359207
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.80125284
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77947414
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70323962
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.59439450
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53329631
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50718302
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49479673
33TP53_22573176_ChIP-Seq_HFKS_Human1.48170697
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46083123
35SOX2_19829295_ChIP-Seq_ESCs_Human1.45737235
36NANOG_19829295_ChIP-Seq_ESCs_Human1.45737235
37LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44527823
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44382702
39CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.42052990
40ETV2_25802403_ChIP-Seq_MESCs_Mouse1.41650740
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40112572
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35773268
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.31168181
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31150534
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30563283
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30410142
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28568141
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.28568141
49NCOR_22424771_ChIP-Seq_293T_Human1.25008992
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22998978
51ER_23166858_ChIP-Seq_MCF-7_Human1.19988262
52P300_19829295_ChIP-Seq_ESCs_Human1.19791096
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19391542
54RNF2_27304074_Chip-Seq_NSC_Mouse1.18038842
55TP53_16413492_ChIP-PET_HCT116_Human1.18029503
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17849344
57HTT_18923047_ChIP-ChIP_STHdh_Human1.14277303
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.13720965
59P53_21459846_ChIP-Seq_SAOS-2_Human1.12884455
60GBX2_23144817_ChIP-Seq_PC3_Human1.12735372
61TTF2_22483619_ChIP-Seq_HELA_Human1.12132196
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11650165
63TAF2_19829295_ChIP-Seq_ESCs_Human1.11319795
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11242933
65CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08519906
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07429814
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06147136
68MYC_19829295_ChIP-Seq_ESCs_Human1.05722272
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.05026768
70ERA_21632823_ChIP-Seq_H3396_Human1.05007488
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04576328
72GATA3_26560356_Chip-Seq_TH2_Human1.02946430
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02675050
74IGF1R_20145208_ChIP-Seq_DFB_Human1.02607860
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00765068
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00190996
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00047800
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00026977
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99872928
80CBX2_27304074_Chip-Seq_ESCs_Mouse0.99150152
81ELK1_22589737_ChIP-Seq_MCF10A_Human0.98067404
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97011250
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95538218
84BP1_19119308_ChIP-ChIP_Hs578T_Human0.94245497
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93373251
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92418742
87CBP_20019798_ChIP-Seq_JUKART_Human0.92418742
88ERG_20517297_ChIP-Seq_VCAP_Human0.90808932
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89684651
90NANOG_20526341_ChIP-Seq_ESCs_Human0.89323999
91TCF4_22108803_ChIP-Seq_LS180_Human0.87922082
92TAL1_26923725_Chip-Seq_HPCs_Mouse0.87682998
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87423075
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87337074
95PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85340537
96RBPJ_21746931_ChIP-Seq_IB4_Human0.84714575
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84163519
98PHF8_20622853_ChIP-Seq_HELA_Human0.84115574
99E2F7_22180533_ChIP-Seq_HELA_Human0.83936882
100SMRT_27268052_Chip-Seq_Bcells_Human0.83763544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer4.82988839
2MP0001835_abnormal_antigen_presentation4.45943707
3MP0006292_abnormal_olfactory_placode4.35327512
4MP0009379_abnormal_foot_pigmentation4.04465506
5MP0008877_abnormal_DNA_methylation2.60446565
6MP0002102_abnormal_ear_morphology2.49390742
7MP0000465_gastrointestinal_hemorrhage2.42393135
8MP0001873_stomach_inflammation2.27247946
9MP0001853_heart_inflammation2.26140045
10MP0002234_abnormal_pharynx_morphology2.08901312
11MP0000427_abnormal_hair_cycle2.07805708
12MP0000383_abnormal_hair_follicle2.01912605
13MP0005646_abnormal_pituitary_gland1.97769752
14MP0008872_abnormal_physiological_respon1.94972701
15MP0000604_amyloidosis1.91351443
16MP0008875_abnormal_xenobiotic_pharmacok1.85838041
17MP0001348_abnormal_lacrimal_gland1.84503062
18MP0004147_increased_porphyrin_level1.80245470
19MP0003122_maternal_imprinting1.77342946
20MP0005253_abnormal_eye_physiology1.74308385
21MP0004142_abnormal_muscle_tone1.73212995
22MP0003880_abnormal_central_pattern1.72038579
23MP0004019_abnormal_vitamin_homeostasis1.71075492
24MP0006082_CNS_inflammation1.68121844
25MP0008995_early_reproductive_senescence1.60425105
26MP0009046_muscle_twitch1.57280862
27MP0003938_abnormal_ear_development1.54377079
28MP0003786_premature_aging1.50495938
29MP0002163_abnormal_gland_morphology1.45607305
30MP0001529_abnormal_vocalization1.41493604
31MP0006072_abnormal_retinal_apoptosis1.40391911
32MP0002876_abnormal_thyroid_physiology1.36700314
33MP0003195_calcinosis1.36635464
34MP0002233_abnormal_nose_morphology1.35864928
35MP0003787_abnormal_imprinting1.33457631
36MP0002009_preneoplasia1.27193307
37MP0008058_abnormal_DNA_repair1.26384450
38MP0006276_abnormal_autonomic_nervous1.26331321
39MP0005551_abnormal_eye_electrophysiolog1.25480582
40MP0010678_abnormal_skin_adnexa1.22932312
41MP0006036_abnormal_mitochondrial_physio1.19997772
42MP0005377_hearing/vestibular/ear_phenot1.18624563
43MP0003878_abnormal_ear_physiology1.18624563
44MP0000678_abnormal_parathyroid_gland1.16618820
45MP0010386_abnormal_urinary_bladder1.15617395
46MP0002938_white_spotting1.13807492
47MP0002837_dystrophic_cardiac_calcinosis1.09331802
48MP0000647_abnormal_sebaceous_gland1.09288808
49MP0000631_abnormal_neuroendocrine_gland1.07364185
50MP0003011_delayed_dark_adaptation1.04788110
51MP0005379_endocrine/exocrine_gland_phen1.04659153
52MP0009764_decreased_sensitivity_to1.04381778
53MP0002736_abnormal_nociception_after1.03658870
54MP0001765_abnormal_ion_homeostasis1.02152921
55MP0002693_abnormal_pancreas_physiology1.01997762
56MP0001905_abnormal_dopamine_level1.01544439
57MP0002282_abnormal_trachea_morphology1.00584802
58MP0001293_anophthalmia0.99865484
59MP0005636_abnormal_mineral_homeostasis0.98292648
60MP0001968_abnormal_touch/_nociception0.97869714
61MP0004084_abnormal_cardiac_muscle0.94718031
62MP0005000_abnormal_immune_tolerance0.94014150
63MP0005367_renal/urinary_system_phenotyp0.90546213
64MP0000516_abnormal_urinary_system0.90546213
65MP0005645_abnormal_hypothalamus_physiol0.86886818
66MP0005671_abnormal_response_to0.86411014
67MP0001346_abnormal_lacrimal_gland0.84146019
68MP0000639_abnormal_adrenal_gland0.82215653
69MP0001286_abnormal_eye_development0.80711979
70MP0003567_abnormal_fetal_cardiomyocyte0.80529594
71MP0003638_abnormal_response/metabolism_0.79466129
72MP0002095_abnormal_skin_pigmentation0.79386892
73MP0002098_abnormal_vibrissa_morphology0.75911407
74MP0002006_tumorigenesis0.75288268
75MP0008789_abnormal_olfactory_epithelium0.74040416
76MP0005085_abnormal_gallbladder_physiolo0.74008755
77MP0002148_abnormal_hypersensitivity_rea0.73972227
78MP0001502_abnormal_circadian_rhythm0.73966337
79MP0005220_abnormal_exocrine_pancreas0.73871195
80MP0002272_abnormal_nervous_system0.73679734
81MP0001845_abnormal_inflammatory_respons0.71747662
82MP0009745_abnormal_behavioral_response0.69811114
83MP0005391_vision/eye_phenotype0.68053827
84MP0001486_abnormal_startle_reflex0.65803783
85MP0001958_emphysema0.65735693
86MP0002277_abnormal_respiratory_mucosa0.64999931
87MP0001986_abnormal_taste_sensitivity0.63498503
88MP0005387_immune_system_phenotype0.62758278
89MP0001790_abnormal_immune_system0.62758278
90MP0009053_abnormal_anal_canal0.62348556
91MP0000049_abnormal_middle_ear0.61547795
92MP0001663_abnormal_digestive_system0.60822962
93MP0000538_abnormal_urinary_bladder0.60385791
94MP0009780_abnormal_chondrocyte_physiolo0.60132944
95MP0001764_abnormal_homeostasis0.58403776
96MP0005084_abnormal_gallbladder_morpholo0.55922962
97MP0002557_abnormal_social/conspecific_i0.55335931
98MP0001664_abnormal_digestion0.54615263
99MP0001756_abnormal_urination0.54472808
100MP0000467_abnormal_esophagus_morphology0.54268204

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.95733059
2Aplastic anemia (HP:0001915)4.84284965
3Acute encephalopathy (HP:0006846)4.70562765
4Hypothermia (HP:0002045)4.61348056
5Abnormal mitochondria in muscle tissue (HP:0008316)4.50954524
6Progressive macrocephaly (HP:0004481)4.24410305
7Mitochondrial inheritance (HP:0001427)3.86912925
8Increased CSF lactate (HP:0002490)3.76417710
9Chronic hepatic failure (HP:0100626)3.45494902
10Hepatocellular necrosis (HP:0001404)3.43838519
11Congenital stationary night blindness (HP:0007642)3.34942412
12Delayed CNS myelination (HP:0002188)3.28306417
13Hepatic necrosis (HP:0002605)3.24595569
14Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.19653500
15Testicular atrophy (HP:0000029)3.08466681
16Generalized aminoaciduria (HP:0002909)2.98263036
17Rib fusion (HP:0000902)2.89729714
18Abnormality of cells of the erythroid lineage (HP:0012130)2.85447610
19Increased serum lactate (HP:0002151)2.78355112
20Macrocytic anemia (HP:0001972)2.75356927
21Polydipsia (HP:0001959)2.73642978
22Abnormal drinking behavior (HP:0030082)2.73642978
23Poor head control (HP:0002421)2.72994662
24Ependymoma (HP:0002888)2.72058465
25Cerebral edema (HP:0002181)2.65867928
26Congenital, generalized hypertrichosis (HP:0004540)2.62546118
27Optic disc pallor (HP:0000543)2.57583379
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.55176840
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.55176840
303-Methylglutaconic aciduria (HP:0003535)2.46621906
31Abolished electroretinogram (ERG) (HP:0000550)2.45532693
32Pancreatic fibrosis (HP:0100732)2.43677549
33Disproportionate short-trunk short stature (HP:0003521)2.42026062
34Leukodystrophy (HP:0002415)2.40708647
35Atonic seizures (HP:0010819)2.40197909
36Pancreatic cysts (HP:0001737)2.39277892
37Abnormality of the renal cortex (HP:0011035)2.37447813
38Limb dystonia (HP:0002451)2.36569880
39Lactic acidosis (HP:0003128)2.34131240
40Hyperlipoproteinemia (HP:0010980)2.34082248
41Arthropathy (HP:0003040)2.31588729
42Hypomagnesemia (HP:0002917)2.28375037
43Delayed myelination (HP:0012448)2.23915664
44Abnormal respiratory motile cilium morphology (HP:0005938)2.22626223
45Abnormal respiratory epithelium morphology (HP:0012253)2.22626223
46Lethargy (HP:0001254)2.20872472
47Abnormal number of erythroid precursors (HP:0012131)2.15882713
48Volvulus (HP:0002580)2.15098907
49True hermaphroditism (HP:0010459)2.14026770
50Exercise intolerance (HP:0003546)2.12881308
51Sensory axonal neuropathy (HP:0003390)2.12732761
52Epileptic encephalopathy (HP:0200134)2.12535014
53Hypokinesia (HP:0002375)2.10517780
54Nephronophthisis (HP:0000090)2.08903569
55Bile duct proliferation (HP:0001408)2.08700308
56Abnormal biliary tract physiology (HP:0012439)2.08700308
57Abnormality of macular pigmentation (HP:0008002)2.07732370
58Abnormality of calcium-phosphate metabolism (HP:0100530)2.07555656
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04776925
60Abnormality of the costochondral junction (HP:0000919)2.01981417
61Tubulointerstitial nephritis (HP:0001970)1.98597543
62Stomatitis (HP:0010280)1.98094313
63Respiratory failure (HP:0002878)1.97753569
64Widely patent fontanelles and sutures (HP:0004492)1.97214853
65Pancytopenia (HP:0001876)1.96347478
66Ragged-red muscle fibers (HP:0003200)1.95765171
67Increased serum pyruvate (HP:0003542)1.95646373
68Chronic sinusitis (HP:0011109)1.94686255
69Renal cortical cysts (HP:0000803)1.90494376
70Redundant skin (HP:0001582)1.88628237
71Thyroid-stimulating hormone excess (HP:0002925)1.87645420
72Agitation (HP:0000713)1.87560034
73Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.87430307
74Abnormality of the renal medulla (HP:0100957)1.86855467
75Beaking of vertebral bodies (HP:0004568)1.86194806
76Polyuria (HP:0000103)1.84564815
77Barrel-shaped chest (HP:0001552)1.82850742
78Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80670451
79CNS hypomyelination (HP:0003429)1.80277750
80Constricted visual fields (HP:0001133)1.80079555
81Spastic paraparesis (HP:0002313)1.79667323
82Renal dysplasia (HP:0000110)1.79195619
83Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.78960965
84Abnormality of dental color (HP:0011073)1.78881493
85Oral leukoplakia (HP:0002745)1.78865375
86Bony spicule pigmentary retinopathy (HP:0007737)1.78547732
87Abnormality of magnesium homeostasis (HP:0004921)1.76824899
88Pendular nystagmus (HP:0012043)1.76763527
89Anencephaly (HP:0002323)1.76309740
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73942411
91Carpal bone hypoplasia (HP:0001498)1.73575456
92Attenuation of retinal blood vessels (HP:0007843)1.72419763
93Abnormality of the phalanges of the 5th finger (HP:0004213)1.71326366
94Abnormal rod and cone electroretinograms (HP:0008323)1.71061273
95Premature ovarian failure (HP:0008209)1.70802209
96Microvesicular hepatic steatosis (HP:0001414)1.70294091
97Type II lissencephaly (HP:0007260)1.70102761
98Reticulocytopenia (HP:0001896)1.69340866
99Enlarged epiphyses (HP:0010580)1.65857699
100Male pseudohermaphroditism (HP:0000037)1.64713000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.02946592
2TRIM285.71487330
3MAP4K23.78753836
4SIK33.11252439
5MAP3K122.86090940
6PIK3CG2.61100499
7EIF2AK32.50377791
8FRK2.29804411
9CDK82.25535788
10ILK2.05460432
11TAOK32.02492937
12NUAK11.85538776
13NME11.82773777
14BMPR21.81539732
15RIPK41.72396901
16SIK21.68407688
17MYLK1.67608156
18NEK11.60075693
19CDK191.46603619
20ADRBK21.46545940
21TRPM71.42129293
22INSRR1.41767590
23IRAK11.35848788
24BRSK21.35309746
25PAK41.35201413
26MST41.32849566
27DYRK21.32204782
28PKN11.25174298
29MAPK131.10165272
30GRK11.10019878
31WNK31.03977866
32TNIK0.94643065
33ZAK0.93603034
34TEC0.92463386
35MKNK20.92392404
36CAMKK20.88768065
37IRAK40.86688202
38GRK70.85921852
39ABL20.85214916
40ERBB30.83679298
41IRAK20.82160174
42SIK10.78337890
43PRKCE0.77859753
44CDK40.77850446
45PBK0.77336746
46DAPK30.75791604
47PLK20.75625011
48PHKG10.71866529
49PHKG20.71866529
50EPHA40.71816573
51DAPK10.69092507
52BMPR1B0.66888584
53CDK70.63641516
54BRSK10.62974067
55MARK30.62798391
56TLK10.62753878
57MKNK10.62273673
58IKBKE0.61999289
59OXSR10.60370396
60PRKG10.59301338
61ADRBK10.56699901
62PRKCG0.56458435
63PIK3CA0.54488730
64TIE10.52546173
65RPS6KA50.52271497
66IKBKB0.49336096
67JAK30.48826468
68LYN0.48210848
69OBSCN0.46825593
70PLK30.46672937
71ATR0.44221464
72CSNK1G30.43302669
73CSNK1G20.43053800
74PDK20.42812708
75MATK0.41546307
76CDC70.40350322
77AURKB0.38593013
78CSNK2A20.37945340
79CSK0.37616970
80TXK0.37049315
81MAPKAPK50.36444239
82RPS6KB20.36346980
83PRKD30.35632408
84PRKD20.34558491
85MAPK120.32691809
86PRKACG0.32446300
87EGFR0.32070578
88PRKACA0.31877287
89BUB10.30945708
90ABL10.30781769
91CSNK1A1L0.30053377
92PRKCA0.29968120
93CSNK1A10.28175639
94IGF1R0.27035960
95PRKACB0.26983529
96ROCK20.25828220
97LCK0.25382791
98MARK10.25328580
99ITK0.24878427
100CAMK2D0.24871830

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.26494023
2Allograft rejection_Homo sapiens_hsa053303.99212207
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.92243621
4Autoimmune thyroid disease_Homo sapiens_hsa053203.79587435
5Protein export_Homo sapiens_hsa030603.34811786
6Oxidative phosphorylation_Homo sapiens_hsa001903.31147762
7Ribosome_Homo sapiens_hsa030103.20223750
8Parkinsons disease_Homo sapiens_hsa050122.89277403
9Type I diabetes mellitus_Homo sapiens_hsa049402.77324279
10Graft-versus-host disease_Homo sapiens_hsa053322.72202690
11Mismatch repair_Homo sapiens_hsa034302.41948358
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29324927
13Proteasome_Homo sapiens_hsa030501.97826875
14One carbon pool by folate_Homo sapiens_hsa006701.93350858
15Alzheimers disease_Homo sapiens_hsa050101.90573346
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83408203
17RNA polymerase_Homo sapiens_hsa030201.72385907
18Fanconi anemia pathway_Homo sapiens_hsa034601.61959834
19Huntingtons disease_Homo sapiens_hsa050161.54506232
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53349955
21Homologous recombination_Homo sapiens_hsa034401.53347751
22DNA replication_Homo sapiens_hsa030301.52742471
23Cardiac muscle contraction_Homo sapiens_hsa042601.52445951
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39226669
25Basal transcription factors_Homo sapiens_hsa030221.37267477
26Selenocompound metabolism_Homo sapiens_hsa004501.34633754
27Rheumatoid arthritis_Homo sapiens_hsa053231.28218926
28Glutathione metabolism_Homo sapiens_hsa004801.27412628
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25449538
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25382368
31Olfactory transduction_Homo sapiens_hsa047401.23757774
32Hematopoietic cell lineage_Homo sapiens_hsa046401.19333782
33Nucleotide excision repair_Homo sapiens_hsa034201.17745886
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12404592
35Base excision repair_Homo sapiens_hsa034101.05968297
36Tryptophan metabolism_Homo sapiens_hsa003801.02848966
37RNA degradation_Homo sapiens_hsa030180.99251687
38Arachidonic acid metabolism_Homo sapiens_hsa005900.93465122
39Phototransduction_Homo sapiens_hsa047440.93202767
40Jak-STAT signaling pathway_Homo sapiens_hsa046300.90790146
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89237652
42Pyrimidine metabolism_Homo sapiens_hsa002400.84624745
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79262691
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78981818
45Butanoate metabolism_Homo sapiens_hsa006500.77299708
46Collecting duct acid secretion_Homo sapiens_hsa049660.75363762
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73091022
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69703414
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.65328170
50Primary immunodeficiency_Homo sapiens_hsa053400.64210905
51RNA transport_Homo sapiens_hsa030130.60892871
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59982491
53Non-homologous end-joining_Homo sapiens_hsa034500.58189118
54Retinol metabolism_Homo sapiens_hsa008300.55965241
55Thyroid hormone synthesis_Homo sapiens_hsa049180.54982529
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54457873
57Systemic lupus erythematosus_Homo sapiens_hsa053220.53060550
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50793698
59Staphylococcus aureus infection_Homo sapiens_hsa051500.49858838
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49782333
61Purine metabolism_Homo sapiens_hsa002300.48530291
62Legionellosis_Homo sapiens_hsa051340.47910187
63T cell receptor signaling pathway_Homo sapiens_hsa046600.45267994
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45207831
65Peroxisome_Homo sapiens_hsa041460.45132789
66Spliceosome_Homo sapiens_hsa030400.42874271
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.41689160
68Vitamin B6 metabolism_Homo sapiens_hsa007500.40677007
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38332122
70Propanoate metabolism_Homo sapiens_hsa006400.37795583
71Linoleic acid metabolism_Homo sapiens_hsa005910.37689640
72Antigen processing and presentation_Homo sapiens_hsa046120.37093394
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33049614
74Metabolic pathways_Homo sapiens_hsa011000.31465556
75Fatty acid degradation_Homo sapiens_hsa000710.31108766
76Tyrosine metabolism_Homo sapiens_hsa003500.28579439
77Folate biosynthesis_Homo sapiens_hsa007900.26810636
78Morphine addiction_Homo sapiens_hsa050320.26686047
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25940688
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25654819
81Circadian entrainment_Homo sapiens_hsa047130.25451729
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25366710
83Insulin secretion_Homo sapiens_hsa049110.25041519
84Leishmaniasis_Homo sapiens_hsa051400.24969761
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23768113
86Ether lipid metabolism_Homo sapiens_hsa005650.23301864
87Vitamin digestion and absorption_Homo sapiens_hsa049770.23255805
88Caffeine metabolism_Homo sapiens_hsa002320.22514969
89Taste transduction_Homo sapiens_hsa047420.22039354
90Nicotine addiction_Homo sapiens_hsa050330.20455658
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19942539
92Viral myocarditis_Homo sapiens_hsa054160.19628420
93Salivary secretion_Homo sapiens_hsa049700.19338031
94Chemical carcinogenesis_Homo sapiens_hsa052040.18718180
95Serotonergic synapse_Homo sapiens_hsa047260.18170797
96Mineral absorption_Homo sapiens_hsa049780.16289272
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16212993
98Measles_Homo sapiens_hsa051620.15619338
99African trypanosomiasis_Homo sapiens_hsa051430.14923104
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.13880813

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