ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	6.69367865
2	dopamine transport (GO:0015872)	6.55778699
3	regulation of isotype switching to IgG isotypes (GO:0048302)	6.31931980
4	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	5.92374611
5	regulation of immunoglobulin secretion (GO:0051023)	5.85647089
6	dopamine biosynthetic process (GO:0042416)	4.42864261
7	proteasome assembly (GO:0043248)	4.36088276
8	iron ion import (GO:0097286)	4.33477471
9	peptidyl-histidine modification (GO:0018202)	4.22777872
10	negative regulation of B cell apoptotic process (GO:0002903)	4.19737814
11	catecholamine transport (GO:0051937)	4.09000765
12	regulation of podosome assembly (GO:0071801)	3.99602364
13	regulation of chronic inflammatory response (GO:0002676)	3.95448447
14	phenol-containing compound catabolic process (GO:0019336)	3.88207173
15	regulation of regulatory T cell differentiation (GO:0045589)	3.82261598
16	ribosome assembly (GO:0042255)	3.81167447
17	otic vesicle formation (GO:0030916)	3.78255534
18	response to lead ion (GO:0010288)	3.76229378
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.55211385
20	water-soluble vitamin biosynthetic process (GO:0042364)	3.54297402
21	negative regulation of acute inflammatory response (GO:0002674)	3.53563117
22	response to manganese ion (GO:0010042)	3.52487499
23	regulation of B cell apoptotic process (GO:0002902)	3.49053086
24	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.44261852
25	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.44261852
26	retinal cone cell development (GO:0046549)	3.34753940
27	positive regulation of DNA recombination (GO:0045911)	3.31211438
28	pteridine-containing compound biosynthetic process (GO:0042559)	3.29702467
29	positive regulation of interleukin-17 production (GO:0032740)	3.26144942
30	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.18849212
31	tRNA processing (GO:0008033)	3.15387298
32	regulation of cellular amino acid metabolic process (GO:0006521)	3.15303483
33	tRNA metabolic process (GO:0006399)	3.04670038
34	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.03895191
35	pseudouridine synthesis (GO:0001522)	3.01926687
36	DNA deamination (GO:0045006)	3.01362217
37	cullin deneddylation (GO:0010388)	3.00795196
38	neurotransmitter biosynthetic process (GO:0042136)	2.99511636
39	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.97681591
40	regulation of meiosis I (GO:0060631)	2.97300919
41	histone H2A acetylation (GO:0043968)	2.94509033
42	zinc ion transmembrane transport (GO:0071577)	2.94126354
43	ATP synthesis coupled proton transport (GO:0015986)	2.93987950
44	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.93987950
45	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.92148821
46	DNA double-strand break processing (GO:0000729)	2.92136593
47	response to insecticide (GO:0017085)	2.92030392
48	positive regulation of granulocyte differentiation (GO:0030854)	2.91723365
49	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.91024703
50	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.91024703
51	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.91024703
52	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.90501906
53	positive regulation of immunoglobulin production (GO:0002639)	2.89817532
54	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.85089710
55	catechol-containing compound biosynthetic process (GO:0009713)	2.82135501
56	catecholamine biosynthetic process (GO:0042423)	2.82135501
57	positive regulation of activated T cell proliferation (GO:0042104)	2.81461585
58	mitochondrial RNA metabolic process (GO:0000959)	2.81182384
59	forebrain morphogenesis (GO:0048853)	2.80715000
60	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.80712921
61	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.80712921
62	aldehyde catabolic process (GO:0046185)	2.80180694
63	prepulse inhibition (GO:0060134)	2.78345606
64	S-adenosylmethionine metabolic process (GO:0046500)	2.76983279
65	positive regulation of isotype switching (GO:0045830)	2.76135803
66	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.75376993
67	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.74300941
68	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.74300941
69	negative regulation of ligase activity (GO:0051352)	2.74141579
70	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.74141579
71	adenosine metabolic process (GO:0046085)	2.74140445
72	regulation of catecholamine metabolic process (GO:0042069)	2.73548125
73	regulation of dopamine metabolic process (GO:0042053)	2.73548125
74	copper ion transport (GO:0006825)	2.72981610
75	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.72609449
76	tryptophan catabolic process (GO:0006569)	2.70141730
77	indole-containing compound catabolic process (GO:0042436)	2.70141730
78	indolalkylamine catabolic process (GO:0046218)	2.70141730
79	rRNA modification (GO:0000154)	2.69286224
80	termination of RNA polymerase III transcription (GO:0006386)	2.69252221
81	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.69252221
82	tRNA modification (GO:0006400)	2.69228969
83	cytochrome complex assembly (GO:0017004)	2.68936927
84	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.68172113
85	termination of RNA polymerase I transcription (GO:0006363)	2.67991186
86	mRNA cleavage (GO:0006379)	2.65215011
87	response to iron ion (GO:0010039)	2.64932245
88	tRNA aminoacylation for protein translation (GO:0006418)	2.63056523
89	ubiquinone biosynthetic process (GO:0006744)	2.61528030
90	respiratory chain complex IV assembly (GO:0008535)	2.60767799
91	cellular ketone body metabolic process (GO:0046950)	2.60408847
92	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.60281888
93	regulation of cellular amine metabolic process (GO:0033238)	2.59469735
94	alkaloid metabolic process (GO:0009820)	2.59259164
95	piRNA metabolic process (GO:0034587)	2.59172300
96	negative regulation of mast cell activation (GO:0033004)	2.57658787
97	tRNA aminoacylation (GO:0043039)	2.57429788
98	amino acid activation (GO:0043038)	2.57429788
99	monoamine transport (GO:0015844)	2.56795209
100	postreplication repair (GO:0006301)	2.56674513

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.43218599
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.72176030
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.48811844
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.37312271
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.70514630
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.55751339
7	ZNF274_21170338_ChIP-Seq_K562_Hela	3.12825877
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.00770324
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.63703929
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.54623009
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.54056568
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.41119014
13	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.30020547
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.23114859
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.22941974
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.17914965
17	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.13456070
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.12274887
19	VDR_22108803_ChIP-Seq_LS180_Human	2.03339750
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.03107113
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.00326863
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.95068440
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93633440
24	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.85539877
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.82239750
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.78888888
27	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.76326385
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73241988
29	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.71670399
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.70549230
31	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.66131298
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.62937326
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.45782098
34	EWS_26573619_Chip-Seq_HEK293_Human	1.43438422
35	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.42539118
36	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41449807
37	DCP1A_22483619_ChIP-Seq_HELA_Human	1.40787267
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.36869884
39	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.35515906
40	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.34853425
41	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.33426421
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.32424365
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29107529
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29107529
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28301079
46	P300_19829295_ChIP-Seq_ESCs_Human	1.26452057
47	ER_23166858_ChIP-Seq_MCF-7_Human	1.26329542
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26314861
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26314861
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21807629
51	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.21429257
52	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17421555
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.17308514
54	FUS_26573619_Chip-Seq_HEK293_Human	1.16456253
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.16229690
56	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.14287582
57	AR_20517297_ChIP-Seq_VCAP_Human	1.12365191
58	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.12173029
59	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.11828764
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08684202
61	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.07927286
62	GBX2_23144817_ChIP-Seq_PC3_Human	1.07554962
63	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.06823553
64	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06667043
65	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.06574781
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05748830
67	CDX2_22108803_ChIP-Seq_LS180_Human	1.04587155
68	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04027279
69	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.03219000
70	GABP_19822575_ChIP-Seq_HepG2_Human	1.02787415
71	GATA3_26560356_Chip-Seq_TH2_Human	1.00546905
72	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.99808224
73	PHF8_20622853_ChIP-Seq_HELA_Human	0.99223293
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98393238
75	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.97115847
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96134050
77	RBPJ_21746931_ChIP-Seq_IB4_Human	0.94332850
78	CBP_20019798_ChIP-Seq_JUKART_Human	0.94049722
79	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.94049722
80	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.92879827
81	ETV1_20927104_ChIP-Seq_GIST48_Human	0.92483795
82	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.92427004
83	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.91341655
84	NCOR_22424771_ChIP-Seq_293T_Human	0.88408494
85	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.88245962
86	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.88006708
87	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.87549536
88	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.85979154
89	HOXB7_26014856_ChIP-Seq_BT474_Human	0.85807072
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.85569810
91	TTF2_22483619_ChIP-Seq_HELA_Human	0.85242164
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.82773363
93	GATA3_26560356_Chip-Seq_TH1_Human	0.81132262
94	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.80735450
95	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.80646976
96	ERG_20517297_ChIP-Seq_VCAP_Human	0.80440400
97	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.79470125
98	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.79045433
99	TCF4_23295773_ChIP-Seq_U87_Human	0.78040811
100	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.77113067

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	8.41802924
2	MP0004147_increased_porphyrin_level	5.27454460
3	MP0006292_abnormal_olfactory_placode	3.72956479
4	MP0002277_abnormal_respiratory_mucosa	3.11047709
5	MP0003195_calcinosis	2.97648206
6	MP0000538_abnormal_urinary_bladder	2.86305835
7	MP0003718_maternal_effect	2.82300855
8	MP0002138_abnormal_hepatobiliary_system	2.69516249
9	MP0008872_abnormal_physiological_respon	2.54248264
10	MP0004043_abnormal_pH_regulation	2.45525767
11	MP0001905_abnormal_dopamine_level	2.35451175
12	MP0001873_stomach_inflammation	2.26079810
13	MP0001835_abnormal_antigen_presentation	1.99813100
14	MP0008877_abnormal_DNA_methylation	1.94986958
15	MP0002102_abnormal_ear_morphology	1.91025065
16	MP0002736_abnormal_nociception_after	1.89797640
17	MP0003011_delayed_dark_adaptation	1.80768909
18	MP0003786_premature_aging	1.76111925
19	MP0005645_abnormal_hypothalamus_physiol	1.74282239
20	MP0008875_abnormal_xenobiotic_pharmacok	1.73303219
21	MP0001756_abnormal_urination	1.71089681
22	MP0001968_abnormal_touch/_nociception	1.68932002
23	MP0000465_gastrointestinal_hemorrhage	1.63091818
24	MP0004782_abnormal_surfactant_physiolog	1.52365839
25	MP0001984_abnormal_olfaction	1.52173051
26	MP0005084_abnormal_gallbladder_morpholo	1.51579042
27	MP0008995_early_reproductive_senescence	1.46850763
28	MP0003656_abnormal_erythrocyte_physiolo	1.43202460
29	MP0001853_heart_inflammation	1.41561171
30	MP0005332_abnormal_amino_acid	1.39847856
31	MP0000604_amyloidosis	1.39336476
32	MP0005310_abnormal_salivary_gland	1.38918530
33	MP0009046_muscle_twitch	1.32632056
34	MP0002139_abnormal_hepatobiliary_system	1.31301286
35	MP0002163_abnormal_gland_morphology	1.30515579
36	MP0005636_abnormal_mineral_homeostasis	1.25776393
37	MP0005379_endocrine/exocrine_gland_phen	1.25183465
38	MP0006072_abnormal_retinal_apoptosis	1.23507191
39	MP0003806_abnormal_nucleotide_metabolis	1.21976856
40	MP0002837_dystrophic_cardiac_calcinosis	1.20365263
41	MP0005395_other_phenotype	1.18032762
42	MP0005551_abnormal_eye_electrophysiolog	1.12962311
43	MP0002166_altered_tumor_susceptibility	1.12698091
44	MP0005646_abnormal_pituitary_gland	1.12093830
45	MP0002160_abnormal_reproductive_system	1.11324377
46	MP0002006_tumorigenesis	1.07931783
47	MP0002009_preneoplasia	1.07436924
48	MP0010329_abnormal_lipoprotein_level	1.04880975
49	MP0000372_irregular_coat_pigmentation	1.03141571
50	MP0006036_abnormal_mitochondrial_physio	0.97283750
51	MP0009745_abnormal_behavioral_response	0.96708252
52	MP0001944_abnormal_pancreas_morphology	0.96470445
53	MP0005365_abnormal_bile_salt	0.96191845
54	MP0001764_abnormal_homeostasis	0.95987352
55	MP0004142_abnormal_muscle_tone	0.95243251
56	MP0001881_abnormal_mammary_gland	0.94708330
57	MP0002693_abnormal_pancreas_physiology	0.93673948
58	MP0000631_abnormal_neuroendocrine_gland	0.93664196
59	MP0001348_abnormal_lacrimal_gland	0.92372784
60	MP0002638_abnormal_pupillary_reflex	0.92130104
61	MP0002876_abnormal_thyroid_physiology	0.91248450
62	MP0003191_abnormal_cellular_cholesterol	0.87394034
63	MP0009697_abnormal_copulation	0.87152402
64	MP0002148_abnormal_hypersensitivity_rea	0.86997656
65	MP0009643_abnormal_urine_homeostasis	0.82649996
66	MP0000647_abnormal_sebaceous_gland	0.82181761
67	MP0002909_abnormal_adrenal_gland	0.80469695
68	MP0001501_abnormal_sleep_pattern	0.78303989
69	MP0009840_abnormal_foam_cell	0.78211738
70	MP0002557_abnormal_social/conspecific_i	0.74882313
71	MP0002234_abnormal_pharynx_morphology	0.74282361
72	MP0003866_abnormal_defecation	0.73478684
73	MP0002272_abnormal_nervous_system	0.73395006
74	MP0005253_abnormal_eye_physiology	0.72877373
75	MP0002210_abnormal_sex_determination	0.72746953
76	MP0000427_abnormal_hair_cycle	0.70731918
77	MP0002572_abnormal_emotion/affect_behav	0.70699358
78	MP0003936_abnormal_reproductive_system	0.70151765
79	MP0001661_extended_life_span	0.69378165
80	MP0005389_reproductive_system_phenotype	0.69329390
81	MP0000653_abnormal_sex_gland	0.69323018
82	MP0001293_anophthalmia	0.69264111
83	MP0001664_abnormal_digestion	0.67992887
84	MP0001919_abnormal_reproductive_system	0.65079397
85	MP0008058_abnormal_DNA_repair	0.64138329
86	MP0001145_abnormal_male_reproductive	0.63999894
87	MP0009780_abnormal_chondrocyte_physiolo	0.63006976
88	MP0000639_abnormal_adrenal_gland	0.62491568
89	MP0001765_abnormal_ion_homeostasis	0.61345221
90	MP0001929_abnormal_gametogenesis	0.60490525
91	MP0004957_abnormal_blastocyst_morpholog	0.58551715
92	MP0001119_abnormal_female_reproductive	0.58200135
93	MP0005386_behavior/neurological_phenoty	0.57807017
94	MP0004924_abnormal_behavior	0.57807017
95	MP0002090_abnormal_vision	0.57800652
96	MP0001845_abnormal_inflammatory_respons	0.57587499
97	MP0000569_abnormal_digit_pigmentation	0.57554649
98	MP0004145_abnormal_muscle_electrophysio	0.57365676
99	MP0003186_abnormal_redox_activity	0.56644503
100	MP0002733_abnormal_thermal_nociception	0.55825989

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Limb dystonia (HP:0002451)	4.74054516
2	Renal cortical cysts (HP:0000803)	4.34193064
3	Tongue fasciculations (HP:0001308)	3.98149084
4	Reduced antithrombin III activity (HP:0001976)	3.69398396
5	Hypoglycemic coma (HP:0001325)	3.68695454
6	Abnormality of the pons (HP:0007361)	3.58804766
7	Generalized aminoaciduria (HP:0002909)	3.54636049
8	Hypoplasia of the pons (HP:0012110)	3.41384959
9	Muscle fibrillation (HP:0010546)	3.36332181
10	Hypothermia (HP:0002045)	3.31618173
11	Increased hepatocellular lipid droplets (HP:0006565)	3.31136151
12	Severe muscular hypotonia (HP:0006829)	3.23730504
13	Increased CSF lactate (HP:0002490)	3.11035069
14	Methylmalonic acidemia (HP:0002912)	3.03529263
15	Type I transferrin isoform profile (HP:0003642)	2.99767658
16	Testicular atrophy (HP:0000029)	2.97133586
17	Cerebellar dysplasia (HP:0007033)	2.96498225
18	Abnormality of vitamin B metabolism (HP:0004340)	2.93783702
19	Methylmalonic aciduria (HP:0012120)	2.91977044
20	Lipid accumulation in hepatocytes (HP:0006561)	2.83758109
21	Neoplasm of the adrenal gland (HP:0100631)	2.83078839
22	Hypokinesia (HP:0002375)	2.82052487
23	Renal Fanconi syndrome (HP:0001994)	2.76783461
24	Neoplasm of the adrenal cortex (HP:0100641)	2.74753944
25	Septo-optic dysplasia (HP:0100842)	2.74533239
26	Abnormality of the renal cortex (HP:0011035)	2.74497091
27	Hepatic necrosis (HP:0002605)	2.73898056
28	Hyperalaninemia (HP:0003348)	2.68429130
29	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.68429130
30	Abnormality of alanine metabolism (HP:0010916)	2.68429130
31	Increased serum lactate (HP:0002151)	2.64277708
32	Type II lissencephaly (HP:0007260)	2.63679930
33	Hypomagnesemia (HP:0002917)	2.60209679
34	Nephronophthisis (HP:0000090)	2.53135224
35	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.50399634
36	Medial flaring of the eyebrow (HP:0010747)	2.46603166
37	Glycosuria (HP:0003076)	2.46362626
38	Abnormality of urine glucose concentration (HP:0011016)	2.46362626
39	Respiratory difficulties (HP:0002880)	2.44643467
40	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.43669641
41	CNS hypomyelination (HP:0003429)	2.38125675
42	Muscular hypotonia of the trunk (HP:0008936)	2.37927724
43	Proximal tubulopathy (HP:0000114)	2.34268793
44	Nausea (HP:0002018)	2.32660447
45	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.29494397
46	Dicarboxylic aciduria (HP:0003215)	2.29494397
47	Mitochondrial inheritance (HP:0001427)	2.27403769
48	Lactic acidosis (HP:0003128)	2.26436405
49	Exertional dyspnea (HP:0002875)	2.26168642
50	Abnormality of methionine metabolism (HP:0010901)	2.25865206
51	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.25364071
52	Abnormal protein N-linked glycosylation (HP:0012347)	2.25364071
53	Abnormal protein glycosylation (HP:0012346)	2.25364071
54	Abnormal glycosylation (HP:0012345)	2.25364071
55	Optic nerve hypoplasia (HP:0000609)	2.24213346
56	Neuroendocrine neoplasm (HP:0100634)	2.23137542
57	Progressive inability to walk (HP:0002505)	2.20209490
58	Stomatitis (HP:0010280)	2.19911413
59	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.16537749
60	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.16537749
61	Increased serum pyruvate (HP:0003542)	2.15007158
62	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.13996089
63	Microvesicular hepatic steatosis (HP:0001414)	2.13616200
64	Abnormality of magnesium homeostasis (HP:0004921)	2.13441664
65	Acute necrotizing encephalopathy (HP:0006965)	2.12519304
66	Congenital, generalized hypertrichosis (HP:0004540)	2.11935333
67	Dyschromatopsia (HP:0007641)	2.11793010
68	Absent thumb (HP:0009777)	2.10553150
69	Progressive macrocephaly (HP:0004481)	2.10513484
70	Increased intramyocellular lipid droplets (HP:0012240)	2.04369875
71	Acute encephalopathy (HP:0006846)	2.04014768
72	Lethargy (HP:0001254)	2.02172531
73	Diminished movement (HP:0002374)	2.01274655
74	Abnormality of vitamin metabolism (HP:0100508)	2.01197376
75	Poor suck (HP:0002033)	1.99872395
76	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.97924594
77	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.95742002
78	Concave nail (HP:0001598)	1.93961160
79	Pheochromocytoma (HP:0002666)	1.93370339
80	Congenital stationary night blindness (HP:0007642)	1.93342410
81	Constricted visual fields (HP:0001133)	1.92397141
82	Arthropathy (HP:0003040)	1.91641728
83	Colon cancer (HP:0003003)	1.91466665
84	Conjunctival hamartoma (HP:0100780)	1.91024278
85	Meckel diverticulum (HP:0002245)	1.86458786
86	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.85342338
87	Large for gestational age (HP:0001520)	1.85147419
88	Abnormality of the renal medulla (HP:0100957)	1.84930093
89	Abnormality of the ileum (HP:0001549)	1.84699358
90	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.83356458
91	Dyskinesia (HP:0100660)	1.77667313
92	Renal tubular dysfunction (HP:0000124)	1.77158060
93	Abnormality of glycolysis (HP:0004366)	1.76964774
94	Abnormal mitochondria in muscle tissue (HP:0008316)	1.76754509
95	Abnormal drinking behavior (HP:0030082)	1.76521066
96	Polydipsia (HP:0001959)	1.76521066
97	Acute hepatic failure (HP:0006554)	1.74054358
98	Megaloblastic anemia (HP:0001889)	1.72077232
99	Abnormality of small intestinal villus morphology (HP:0011472)	1.71723009
100	Villous atrophy (HP:0011473)	1.71723009

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR1B	4.39743069
2	PBK	4.15451503
3	FRK	3.96495920
4	BUB1	3.56047791
5	CDK8	3.37823320
6	TSSK6	2.90003285
7	EIF2AK3	2.87419864
8	ZAK	2.73964497
9	PKN2	2.49285582
10	EIF2AK1	2.42647879
11	PNCK	2.34818765
12	FLT3	2.15122481
13	GRK1	2.14514656
14	TGFBR1	2.11678602
15	MST4	2.02470120
16	AKT3	1.82863467
17	ACVR1B	1.77705125
18	ADRBK2	1.62959067
19	BCKDK	1.62344218
20	TLK1	1.57060335
21	MAP4K2	1.52931123
22	MKNK2	1.52819120
23	FGFR2	1.46434909
24	TAOK3	1.43762140
25	WNK3	1.42272633
26	PDK2	1.41939431
27	PHKG1	1.40902356
28	PHKG2	1.40902356
29	WNK4	1.40788916
30	PLK3	1.30820268
31	MAP3K12	1.30480513
32	NME1	1.29587712
33	NEK1	1.28551052
34	OXSR1	1.26461201
35	MAPKAPK5	1.23742504
36	TRIM28	1.20552452
37	PINK1	1.17759470
38	SIK3	1.15931304
39	TESK1	1.07384246
40	SCYL2	1.07377413
41	STK39	1.06593144
42	VRK2	1.02710426
43	TTK	0.91246925
44	NUAK1	0.87550569
45	EIF2AK2	0.84447610
46	ITK	0.80239086
47	PRKCG	0.77809283
48	FES	0.74876694
49	TEC	0.70626429
50	MKNK1	0.70502112
51	PLK1	0.70376701
52	FGFR1	0.70097280
53	MAP2K6	0.69973188
54	SRPK1	0.68975997
55	LIMK1	0.67880663
56	PLK2	0.67257839
57	CSNK1G1	0.65251817
58	INSRR	0.62530132
59	PASK	0.62190511
60	WEE1	0.59601195
61	PLK4	0.58634929
62	VRK1	0.58447851
63	BCR	0.54079046
64	CDK9	0.52625255
65	GRK5	0.52127187
66	PRKG2	0.52039497
67	NEK2	0.49052391
68	CAMK2D	0.47533353
69	CSNK1G2	0.46051955
70	PAK3	0.45562295
71	PRKCE	0.43815041
72	CAMK2A	0.41771040
73	CSNK1G3	0.39865978
74	ATR	0.39443344
75	NLK	0.38350632
76	PTK2B	0.34458517
77	PIK3CG	0.34435043
78	FGR	0.32501020
79	CSNK2A2	0.31807316
80	TNK2	0.31699639
81	ADRBK1	0.30697814
82	STK3	0.30642769
83	RPS6KA5	0.30171844
84	ATM	0.29455248
85	PTK2	0.29216867
86	RPS6KB1	0.29084583
87	PIM1	0.28437880
88	IKBKB	0.26242085
89	PRKAA1	0.24670369
90	PRKCA	0.24453885
91	CSNK1A1	0.23207387
92	CSNK2A1	0.22965904
93	DAPK2	0.21905840
94	OBSCN	0.20820579
95	PRKACB	0.20795582
96	CDK3	0.19510312
97	WNK1	0.19342641
98	TIE1	0.19009755
99	MAP3K4	0.18657330
100	BRSK2	0.18498490

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.86980175
2	Protein export_Homo sapiens_hsa03060	3.48214313
3	Asthma_Homo sapiens_hsa05310	3.05394790
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.92222124
5	RNA polymerase_Homo sapiens_hsa03020	2.65268984
6	Allograft rejection_Homo sapiens_hsa05330	2.58272475
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.48583802
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.27563461
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.08655760
10	Folate biosynthesis_Homo sapiens_hsa00790	2.02895765
11	Parkinsons disease_Homo sapiens_hsa05012	1.98907621
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.96873158
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.94953273
14	Propanoate metabolism_Homo sapiens_hsa00640	1.91872814
15	Butanoate metabolism_Homo sapiens_hsa00650	1.88065643
16	Fatty acid elongation_Homo sapiens_hsa00062	1.84135236
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.83054984
18	Basal transcription factors_Homo sapiens_hsa03022	1.82831838
19	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.77233114
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.76418538
21	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.68415660
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.52260715
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.44176138
24	Graft-versus-host disease_Homo sapiens_hsa05332	1.42210413
25	RNA degradation_Homo sapiens_hsa03018	1.41153013
26	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.40228856
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.36453366
28	Homologous recombination_Homo sapiens_hsa03440	1.36305795
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.33960491
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.32744423
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.31808038
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.28617784
33	One carbon pool by folate_Homo sapiens_hsa00670	1.25956876
34	RNA transport_Homo sapiens_hsa03013	1.23439668
35	Mineral absorption_Homo sapiens_hsa04978	1.20290874
36	Cocaine addiction_Homo sapiens_hsa05030	1.15948288
37	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.15015390
38	Phototransduction_Homo sapiens_hsa04744	1.10417370
39	Peroxisome_Homo sapiens_hsa04146	1.09716024
40	Purine metabolism_Homo sapiens_hsa00230	1.08860088
41	Base excision repair_Homo sapiens_hsa03410	1.03045651
42	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.97024435
43	Fanconi anemia pathway_Homo sapiens_hsa03460	0.95267322
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.91948337
45	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.91439821
46	Amphetamine addiction_Homo sapiens_hsa05031	0.90275302
47	Regulation of autophagy_Homo sapiens_hsa04140	0.89328631
48	Non-homologous end-joining_Homo sapiens_hsa03450	0.87547392
49	Linoleic acid metabolism_Homo sapiens_hsa00591	0.85204353
50	Rheumatoid arthritis_Homo sapiens_hsa05323	0.82692403
51	Sulfur metabolism_Homo sapiens_hsa00920	0.81511264
52	Nitrogen metabolism_Homo sapiens_hsa00910	0.81432202
53	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.80637075
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.80622755
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79109079
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.78419377
57	Mismatch repair_Homo sapiens_hsa03430	0.77092839
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.74585033
59	Ribosome_Homo sapiens_hsa03010	0.73700538
60	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.73570704
61	Huntingtons disease_Homo sapiens_hsa05016	0.72301182
62	Olfactory transduction_Homo sapiens_hsa04740	0.72199643
63	Sulfur relay system_Homo sapiens_hsa04122	0.71363900
64	Taste transduction_Homo sapiens_hsa04742	0.70855534
65	Alzheimers disease_Homo sapiens_hsa05010	0.67761995
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.64972371
67	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63972299
68	Metabolic pathways_Homo sapiens_hsa01100	0.63925685
69	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63786846
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.62238090
71	Insulin secretion_Homo sapiens_hsa04911	0.61552866
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61248607
73	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.61064873
74	Fatty acid degradation_Homo sapiens_hsa00071	0.60096451
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59907567
76	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.59279406
77	Antigen processing and presentation_Homo sapiens_hsa04612	0.59036315
78	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.55486845
79	Caffeine metabolism_Homo sapiens_hsa00232	0.54318890
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.54104081
81	Legionellosis_Homo sapiens_hsa05134	0.53388367
82	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.52883846
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.48542450
84	Carbon metabolism_Homo sapiens_hsa01200	0.47163268
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.44740182
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.44620940
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44193188
88	Cardiac muscle contraction_Homo sapiens_hsa04260	0.42421975
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40665860
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40298717
91	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38081156
92	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.37253329
93	Salivary secretion_Homo sapiens_hsa04970	0.36787683
94	Nicotine addiction_Homo sapiens_hsa05033	0.36332521
95	Spliceosome_Homo sapiens_hsa03040	0.34468196
96	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.31929867
97	Retinol metabolism_Homo sapiens_hsa00830	0.31842211
98	Vibrio cholerae infection_Homo sapiens_hsa05110	0.30421992
99	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30398077
100	Primary immunodeficiency_Homo sapiens_hsa05340	0.28151034

OSTCP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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