OSTCP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of interleukin-17 production (GO:0032740)9.08730419
2positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)8.06420711
3regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)7.58994221
4regulation of isotype switching to IgG isotypes (GO:0048302)7.10394073
5protein neddylation (GO:0045116)6.57511104
6positive regulation of natural killer cell differentiation (GO:0032825)6.04409159
7regulation of regulatory T cell differentiation (GO:0045589)5.27809484
8positive regulation of isotype switching (GO:0045830)5.20051821
9regulation of interleukin-17 production (GO:0032660)5.01945568
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.93919356
11positive regulation of DNA recombination (GO:0045911)4.82942745
12regulation of immunoglobulin secretion (GO:0051023)4.73412688
13regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)4.63321966
14regulation of natural killer cell differentiation (GO:0032823)4.47813621
15cellular response to interleukin-15 (GO:0071350)4.39678395
16positive regulation of activated T cell proliferation (GO:0042104)4.26781110
17adenosine metabolic process (GO:0046085)4.17017305
18regulation of chronic inflammatory response (GO:0002676)4.08839323
19response to interleukin-15 (GO:0070672)3.98184355
20positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.97877342
21negative regulation of B cell apoptotic process (GO:0002903)3.89736620
22positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.82663865
23DNA deamination (GO:0045006)3.80337080
24sequestering of actin monomers (GO:0042989)3.66950795
25positive regulation of immunoglobulin production (GO:0002639)3.65181472
26UMP metabolic process (GO:0046049)3.64006137
27pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.64006137
28UMP biosynthetic process (GO:0006222)3.64006137
29pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.64006137
30signal peptide processing (GO:0006465)3.55901082
31positive regulation of tissue remodeling (GO:0034105)3.49754902
32serotonin receptor signaling pathway (GO:0007210)3.49590864
33positive regulation of immunoglobulin mediated immune response (GO:0002891)3.49131428
34positive regulation of B cell mediated immunity (GO:0002714)3.49131428
35regulation of isotype switching (GO:0045191)3.46665554
36regulation of tyrosine phosphorylation of STAT protein (GO:0042509)3.45885289
37proteasome assembly (GO:0043248)3.44500280
38positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.41487740
39positive regulation of JAK-STAT cascade (GO:0046427)3.41355787
40negative regulation of T cell differentiation in thymus (GO:0033085)3.39526556
41pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.38426096
42regulation of activated T cell proliferation (GO:0046006)3.35757407
43mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.31927642
44positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.31927642
45positive regulation of natural killer cell mediated immunity (GO:0002717)3.28947913
46negative regulation of acute inflammatory response (GO:0002674)3.26764558
47water-soluble vitamin biosynthetic process (GO:0042364)3.22589193
48pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.20858946
49positive regulation of interleukin-10 production (GO:0032733)3.20180875
50CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.17875468
51L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.11358508
52cytidine deamination (GO:0009972)3.11260742
53cytidine metabolic process (GO:0046087)3.11260742
54cytidine catabolic process (GO:0006216)3.11260742
55IMP metabolic process (GO:0046040)3.03819425
56positive regulation of cell fate commitment (GO:0010455)3.01482130
57positive regulation of B cell proliferation (GO:0030890)3.01004249
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.00648851
59antigen processing and presentation via MHC class Ib (GO:0002475)2.97938736
60deoxyribonucleotide biosynthetic process (GO:0009263)2.96641895
61negative regulation of membrane potential (GO:0045837)2.95877375
62negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.95203102
63regulation of cellular amino acid metabolic process (GO:0006521)2.92736601
64pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.91858362
65retinal rod cell development (GO:0046548)2.89763984
66positive regulation of interferon-gamma production (GO:0032729)2.89002495
67natural killer cell activation (GO:0030101)2.88902989
68regulation of B cell receptor signaling pathway (GO:0050855)2.88693593
69platelet dense granule organization (GO:0060155)2.87711927
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.84739789
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.84739789
72pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.82215385
73cullin deneddylation (GO:0010388)2.81314027
74protein peptidyl-prolyl isomerization (GO:0000413)2.80477050
75negative regulation of heart contraction (GO:0045822)2.80154262
76pyrimidine nucleotide biosynthetic process (GO:0006221)2.79387879
77fucose catabolic process (GO:0019317)2.78367072
78L-fucose metabolic process (GO:0042354)2.78367072
79L-fucose catabolic process (GO:0042355)2.78367072
80negative regulation of mast cell activation (GO:0033004)2.77515635
81regulation of immunoglobulin production (GO:0002637)2.75998968
82pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.75340903
83deoxyribose phosphate biosynthetic process (GO:0046385)2.74611873
842-deoxyribonucleotide biosynthetic process (GO:0009265)2.74611873
85pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.74245371
86negative regulation of calcium ion transport into cytosol (GO:0010523)2.73775762
87sphingosine metabolic process (GO:0006670)2.71696253
88positive regulation of lymphocyte mediated immunity (GO:0002708)2.71005435
89regulation of interleukin-8 secretion (GO:2000482)2.69295525
90regulation of natural killer cell activation (GO:0032814)2.67657935
91positive regulation of natural killer cell activation (GO:0032816)2.67471517
92positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.67409043
93positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.66788471
94pyrimidine ribonucleoside metabolic process (GO:0046131)2.65472683
95aldehyde catabolic process (GO:0046185)2.63200402
96sleep (GO:0030431)2.62718239
97protein deneddylation (GO:0000338)2.61718701
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.60900135
99diol metabolic process (GO:0034311)2.59068368
100pyrimidine ribonucleoside catabolic process (GO:0046133)2.58356268

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.19419260
2TAF15_26573619_Chip-Seq_HEK293_Human4.14557030
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.58217843
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.47277725
5VDR_22108803_ChIP-Seq_LS180_Human3.30100657
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14187370
7FLI1_27457419_Chip-Seq_LIVER_Mouse3.07643265
8EWS_26573619_Chip-Seq_HEK293_Human2.65552835
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.49322443
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.46078966
11VDR_23849224_ChIP-Seq_CD4+_Human2.45395106
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.42847311
13ZNF274_21170338_ChIP-Seq_K562_Hela2.42704532
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33073040
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31818467
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31684052
17GATA1_22025678_ChIP-Seq_K562_Human2.20815160
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14924973
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14831713
20PCGF2_27294783_Chip-Seq_NPCs_Mouse2.09285433
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08841297
22FOXP3_21729870_ChIP-Seq_TREG_Human1.96732316
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96104672
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95702717
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92548934
26ELK1_19687146_ChIP-ChIP_HELA_Human1.89880436
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79779601
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.78300697
29P300_19829295_ChIP-Seq_ESCs_Human1.73946449
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66851253
31FUS_26573619_Chip-Seq_HEK293_Human1.66438814
32GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.64330913
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63450883
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.60359622
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.57465065
36GBX2_23144817_ChIP-Seq_PC3_Human1.56764114
37RUNX_20019798_ChIP-Seq_JUKART_Human1.56619215
38GATA3_26560356_Chip-Seq_TH2_Human1.54301806
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52486287
40IGF1R_20145208_ChIP-Seq_DFB_Human1.51178732
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.50924716
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46363797
43NANOG_19829295_ChIP-Seq_ESCs_Human1.45733885
44SOX2_19829295_ChIP-Seq_ESCs_Human1.45733885
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.45143952
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41082252
47AUTS2_25519132_ChIP-Seq_293T-REX_Human1.39536232
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38854813
49MYC_18940864_ChIP-ChIP_HL60_Human1.37859187
50CRX_20693478_ChIP-Seq_RETINA_Mouse1.36082753
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.33674412
52STAT3_18555785_Chip-Seq_ESCs_Mouse1.30112434
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30028635
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28669308
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.27647925
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27647925
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25746028
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24423394
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21328405
60P53_22387025_ChIP-Seq_ESCs_Mouse1.19115326
61TAL1_26923725_Chip-Seq_HPCs_Mouse1.18041345
62AR_20517297_ChIP-Seq_VCAP_Human1.18025265
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17533050
64MYB_26560356_Chip-Seq_TH2_Human1.16051168
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14552389
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.14544543
67TP53_22573176_ChIP-Seq_HFKS_Human1.14515679
68P300_18555785_Chip-Seq_ESCs_Mouse1.14163188
69ER_23166858_ChIP-Seq_MCF-7_Human1.13592541
70OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12775252
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11173629
72EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11008793
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10763435
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09640084
75CBP_20019798_ChIP-Seq_JUKART_Human1.09432241
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09432241
77OCT4_18555785_Chip-Seq_ESCs_Mouse1.07321482
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06499694
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.05571749
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04398654
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04163268
82TCF4_22108803_ChIP-Seq_LS180_Human1.03813251
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03515353
84PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03150691
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02556582
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02353675
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02291550
88SMAD_19615063_ChIP-ChIP_OVARY_Human0.99932575
89TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99607357
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99428186
91CDX2_22108803_ChIP-Seq_LS180_Human0.98688990
92NMYC_18555785_Chip-Seq_ESCs_Mouse0.98659231
93CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97493552
94MYC_18555785_ChIP-Seq_MESCs_Mouse0.97063256
95SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96746575
96NANOG_18555785_Chip-Seq_ESCs_Mouse0.96555180
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96549996
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96427290
99STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96280618
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.96087954

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.65004955
2MP0000465_gastrointestinal_hemorrhage3.17971012
3MP0008877_abnormal_DNA_methylation2.73001413
4MP0001853_heart_inflammation2.60186312
5MP0005084_abnormal_gallbladder_morpholo2.59976958
6MP0003300_gastrointestinal_ulcer2.59747816
7MP0006072_abnormal_retinal_apoptosis2.53822098
8MP0002102_abnormal_ear_morphology2.53713210
9MP0003195_calcinosis2.51325255
10MP0000372_irregular_coat_pigmentation2.51216480
11MP0004147_increased_porphyrin_level2.34384530
12MP0002166_altered_tumor_susceptibility2.28385719
13MP0008872_abnormal_physiological_respon2.19399242
14MP0000604_amyloidosis2.10265930
15MP0004742_abnormal_vestibular_system2.10024220
16MP0010368_abnormal_lymphatic_system2.08588946
17MP0003787_abnormal_imprinting2.06991947
18MP0002138_abnormal_hepatobiliary_system2.04105161
19MP0002837_dystrophic_cardiac_calcinosis2.04065095
20MP0003136_yellow_coat_color2.02182680
21MP0003567_abnormal_fetal_cardiomyocyte1.90878874
22MP0009785_altered_susceptibility_to1.88264643
23MP0003045_fibrosis1.87819207
24MP0002148_abnormal_hypersensitivity_rea1.83859381
25MP0005671_abnormal_response_to1.81863906
26MP0006082_CNS_inflammation1.79843603
27MP0002405_respiratory_system_inflammati1.75591967
28MP0002163_abnormal_gland_morphology1.75051056
29MP0000569_abnormal_digit_pigmentation1.72992024
30MP0001790_abnormal_immune_system1.72423769
31MP0005387_immune_system_phenotype1.72423769
32MP0009697_abnormal_copulation1.70932296
33MP0001348_abnormal_lacrimal_gland1.68666515
34MP0002876_abnormal_thyroid_physiology1.68161349
35MP0002006_tumorigenesis1.65838981
36MP0005075_abnormal_melanosome_morpholog1.59875456
37MP0002638_abnormal_pupillary_reflex1.49824919
38MP0001984_abnormal_olfaction1.46193524
39MP0003880_abnormal_central_pattern1.44373944
40MP0004145_abnormal_muscle_electrophysio1.43731521
41MP0003172_abnormal_lysosome_physiology1.42992720
42MP0004084_abnormal_cardiac_muscle1.42932854
43MP0005000_abnormal_immune_tolerance1.40061313
44MP0010386_abnormal_urinary_bladder1.31799491
45MP0002090_abnormal_vision1.30899374
46MP0002938_white_spotting1.28279275
47MP0001800_abnormal_humoral_immune1.27972312
48MP0003786_premature_aging1.24685906
49MP0002009_preneoplasia1.19166260
50MP0003724_increased_susceptibility_to1.19131949
51MP0003252_abnormal_bile_duct1.18236123
52MP0002736_abnormal_nociception_after1.18048977
53MP0003011_delayed_dark_adaptation1.17140224
54MP0005187_abnormal_penis_morphology1.15835705
55MP0004381_abnormal_hair_follicle1.11343729
56MP0001873_stomach_inflammation1.03555912
57MP0003122_maternal_imprinting1.00865995
58MP0005220_abnormal_exocrine_pancreas1.00851183
59MP0004142_abnormal_muscle_tone0.99155805
60MP0003221_abnormal_cardiomyocyte_apopto0.96884606
61MP0004036_abnormal_muscle_relaxation0.96596961
62MP0005551_abnormal_eye_electrophysiolog0.95751458
63MP0002272_abnormal_nervous_system0.95142108
64MP0002420_abnormal_adaptive_immunity0.93378724
65MP0002723_abnormal_immune_serum0.93228903
66MP0008995_early_reproductive_senescence0.93198586
67MP0005167_abnormal_blood-brain_barrier0.92593343
68MP0001845_abnormal_inflammatory_respons0.92295339
69MP0008057_abnormal_DNA_replication0.90049928
70MP0000689_abnormal_spleen_morphology0.89095863
71MP0008775_abnormal_heart_ventricle0.88450691
72MP0002693_abnormal_pancreas_physiology0.88168162
73MP0003866_abnormal_defecation0.87746831
74MP0009745_abnormal_behavioral_response0.87660377
75MP0002452_abnormal_antigen_presenting0.87602155
76MP0005253_abnormal_eye_physiology0.86805664
77MP0008875_abnormal_xenobiotic_pharmacok0.85387424
78MP0003646_muscle_fatigue0.84474045
79MP0005379_endocrine/exocrine_gland_phen0.84142973
80MP0001819_abnormal_immune_cell0.84120888
81MP0005174_abnormal_tail_pigmentation0.82668392
82MP0001485_abnormal_pinna_reflex0.80669551
83MP0006036_abnormal_mitochondrial_physio0.80415105
84MP0004782_abnormal_surfactant_physiolog0.74993181
85MP0004019_abnormal_vitamin_homeostasis0.73347424
86MP0001243_abnormal_dermal_layer0.70908379
87MP0001968_abnormal_touch/_nociception0.70784178
88MP0001501_abnormal_sleep_pattern0.70649633
89MP0005025_abnormal_response_to0.70399922
90MP0003121_genomic_imprinting0.69697144
91MP0005310_abnormal_salivary_gland0.68194190
92MP0004883_abnormal_blood_vessel0.67207633
93MP0002751_abnormal_autonomic_nervous0.66450115
94MP0001502_abnormal_circadian_rhythm0.65697804
95MP0001119_abnormal_female_reproductive0.65554951
96MP0005645_abnormal_hypothalamus_physiol0.64837111
97MP0004215_abnormal_myocardial_fiber0.63473351
98MP0001293_anophthalmia0.62708119
99MP0003878_abnormal_ear_physiology0.61849070
100MP0005377_hearing/vestibular/ear_phenot0.61849070

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)5.95326689
2Hyperalaninemia (HP:0003348)5.95326689
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.95326689
4Chronic diarrhea (HP:0002028)4.73436737
5T lymphocytopenia (HP:0005403)4.20617548
6Abnormality of midbrain morphology (HP:0002418)3.88962891
7Molar tooth sign on MRI (HP:0002419)3.88962891
8Abnormality of T cell number (HP:0011839)3.74792729
9Severe combined immunodeficiency (HP:0004430)3.47071293
10Acute necrotizing encephalopathy (HP:0006965)3.46411568
11Aplastic anemia (HP:0001915)3.40446830
12Acute encephalopathy (HP:0006846)3.37245480
13Nephronophthisis (HP:0000090)3.35801674
14Stomatitis (HP:0010280)3.35489556
15Abnormality of serum amino acid levels (HP:0003112)3.22141636
16Renal cortical cysts (HP:0000803)3.17169982
17Thyroiditis (HP:0100646)3.10035810
18Increased CSF lactate (HP:0002490)2.97142547
19Abnormal mitochondria in muscle tissue (HP:0008316)2.95534732
20Mitochondrial inheritance (HP:0001427)2.94880651
21IgG deficiency (HP:0004315)2.91195561
22Abnormality of T cells (HP:0002843)2.88494432
23Methylmalonic acidemia (HP:0002912)2.85926581
24Progressive macrocephaly (HP:0004481)2.84234448
25Combined immunodeficiency (HP:0005387)2.72365889
26Abnormality of T cell physiology (HP:0011840)2.69264149
27Constricted visual fields (HP:0001133)2.64960007
28Acute hepatic failure (HP:0006554)2.64797224
29Elevated erythrocyte sedimentation rate (HP:0003565)2.61448275
30Hypoproteinemia (HP:0003075)2.51693276
31Abolished electroretinogram (ERG) (HP:0000550)2.48065070
32Abnormality of the prostate (HP:0008775)2.43174567
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.41481188
34Optic disc pallor (HP:0000543)2.41478023
35Panhypogammaglobulinemia (HP:0003139)2.40311499
36Adactyly (HP:0009776)2.38479490
37Anhidrosis (HP:0000970)2.38158605
38Acanthocytosis (HP:0001927)2.38062472
39Abnormality of the renal medulla (HP:0100957)2.37747696
40Supernumerary spleens (HP:0009799)2.36876491
41Cerebral edema (HP:0002181)2.33904737
42Abnormality of aspartate family amino acid metabolism (HP:0010899)2.29604504
43Confusion (HP:0001289)2.26622257
44Central scotoma (HP:0000603)2.24313338
45Short tibia (HP:0005736)2.23857829
46B lymphocytopenia (HP:0010976)2.22556980
47Hypomagnesemia (HP:0002917)2.22489940
48Poor speech (HP:0002465)2.20992813
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.17950020
50Abnormality of the renal cortex (HP:0011035)2.17576523
51Increased serum lactate (HP:0002151)2.16263671
52Poor head control (HP:0002421)2.14959020
53Sensorimotor neuropathy (HP:0007141)2.14669555
54Dyschromatopsia (HP:0007641)2.14197636
55Abnormality of B cell number (HP:0010975)2.11237558
56Lethargy (HP:0001254)2.07981763
57Inflammation of the large intestine (HP:0002037)2.07757448
58Hepatic necrosis (HP:0002605)2.05940340
59Abnormality of methionine metabolism (HP:0010901)2.04957749
60Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03924304
61Methylmalonic aciduria (HP:0012120)2.02392389
62Leukodystrophy (HP:0002415)2.01583797
63Pancytopenia (HP:0001876)1.99323265
64Concave nail (HP:0001598)1.97644489
65Conical tooth (HP:0000698)1.96593648
66Hepatocellular necrosis (HP:0001404)1.96181768
67Long foot (HP:0001833)1.93858723
68Abnormality of binocular vision (HP:0011514)1.93604910
69Diplopia (HP:0000651)1.93604910
70Megaloblastic anemia (HP:0001889)1.93305917
71Exertional dyspnea (HP:0002875)1.90207361
72Ureteral stenosis (HP:0000071)1.89708756
73Pancreatic cysts (HP:0001737)1.89117104
74Hyperglycinuria (HP:0003108)1.87080802
75Recurrent viral infections (HP:0004429)1.86896890
76Hepatoblastoma (HP:0002884)1.86665877
77Chronic mucocutaneous candidiasis (HP:0002728)1.86619182
78Recurrent cutaneous fungal infections (HP:0011370)1.86619182
79Abnormality of the vitamin B12 metabolism (HP:0004341)1.84783237
80Flared iliac wings (HP:0002869)1.82712936
81Abnormality of glycolipid metabolism (HP:0010969)1.82015068
82Abnormality of liposaccharide metabolism (HP:0010968)1.82015068
83Abnormality of glycosphingolipid metabolism (HP:0004343)1.82015068
84Respiratory difficulties (HP:0002880)1.81563114
85Tubular atrophy (HP:0000092)1.81307866
86Gastrointestinal inflammation (HP:0004386)1.80392070
87Abnormal delayed hypersensitivity skin test (HP:0002963)1.80386068
88Recurrent bronchitis (HP:0002837)1.80252520
89Abnormality of the proximal phalanges of the hand (HP:0009834)1.79965052
90Increased hepatocellular lipid droplets (HP:0006565)1.79955795
91Attenuation of retinal blood vessels (HP:0007843)1.79894765
92Abnormality of serine family amino acid metabolism (HP:0010894)1.79594552
93Abnormality of glycine metabolism (HP:0010895)1.79594552
94Megalencephaly (HP:0001355)1.78827350
95True hermaphroditism (HP:0010459)1.78698844
96Rhabdomyolysis (HP:0003201)1.78073186
97Gastrointestinal infarctions (HP:0005244)1.77262920
98Lactic acidosis (HP:0003128)1.76351512
99Abnormality of the fovea (HP:0000493)1.75225298
100Respiratory failure (HP:0002878)1.74136841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.76275645
2EIF2AK22.98418752
3BCR2.97586404
4STK392.40744365
5EIF2AK12.28162564
6NEK12.05617882
7ERBB32.01605394
8CSNK1A1L1.99558072
9MAP4K21.91482523
10PDK21.91441764
11TXK1.90675525
12BMPR1B1.81636634
13CSNK1G31.81252754
14CSNK1G11.77754296
15WNK41.77314949
16PAK61.72567792
17STK161.71270950
18MAP3K141.65105382
19TRIM281.64219984
20FRK1.63249001
21TIE11.56907696
22CSNK1G21.53922222
23TEC1.53430191
24TSSK61.52877059
25MAPK131.50367280
26MAP3K121.50027037
27KDR1.49363751
28OXSR11.49187045
29TLK11.47724061
30UHMK11.44266973
31CDK81.38962636
32PAK31.33719005
33JAK11.33458848
34NEK91.31861944
35BMPR21.28890678
36IKBKE1.24642315
37ADRBK21.22815172
38SIK31.20794949
39BCKDK1.18260277
40MYLK1.06937738
41DYRK21.05225523
42GRK11.04688385
43RPS6KA41.03979408
44WNK31.01890303
45SRPK11.00557640
46MST40.99378844
47ITK0.96416500
48IKBKB0.93145820
49WEE10.90024330
50DAPK10.87102471
51PLK30.86248526
52PHKG20.83040681
53PHKG10.83040681
54PAK40.82328695
55LYN0.79421226
56MKNK10.75153290
57TGFBR20.73438028
58MAP3K40.72599658
59CAMK40.72168455
60ATR0.71562992
61TRPM70.71323602
62MKNK20.70659737
63NUAK10.64575769
64PRKCE0.63353114
65ZAK0.62651941
66GRK70.60565273
67VRK10.60028629
68INSRR0.59618951
69FGFR10.58736886
70CAMK2A0.57657478
71KIT0.56514992
72EGFR0.56122636
73KSR10.55399651
74CHUK0.55163544
75IGF1R0.55074826
76PKN10.54756040
77PIM10.51054198
78PRKCQ0.49994037
79FLT30.48919707
80NTRK20.48593331
81TGFBR10.47134421
82CSNK2A10.46334379
83PRKACB0.43726101
84INSR0.43222025
85VRK20.41992187
86CAMKK20.41889341
87CAMK2B0.41128462
88CSNK1A10.41057051
89LIMK10.40631862
90CSNK1D0.39657555
91ABL10.38592250
92CSNK2A20.37696736
93SCYL20.37429006
94PRKACG0.37145556
95PRKAA20.35938184
96OBSCN0.35110266
97PRKCA0.35084653
98PRKCB0.34904313
99JAK30.34413599
100CDK70.33703130

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.49196841
2Proteasome_Homo sapiens_hsa030503.65363925
3Asthma_Homo sapiens_hsa053103.45043405
4Allograft rejection_Homo sapiens_hsa053302.83687451
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.74317972
6Autoimmune thyroid disease_Homo sapiens_hsa053202.65441475
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.42906560
8Graft-versus-host disease_Homo sapiens_hsa053322.37723235
9Propanoate metabolism_Homo sapiens_hsa006402.31790348
10Primary immunodeficiency_Homo sapiens_hsa053402.28775389
11Oxidative phosphorylation_Homo sapiens_hsa001902.25387758
12Type I diabetes mellitus_Homo sapiens_hsa049402.20579248
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14267355
14Hematopoietic cell lineage_Homo sapiens_hsa046402.04774358
15Basal transcription factors_Homo sapiens_hsa030222.00125532
16Parkinsons disease_Homo sapiens_hsa050121.86090185
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85597754
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82202942
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.66029745
20Rheumatoid arthritis_Homo sapiens_hsa053231.59825903
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.57413517
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52852339
23RNA polymerase_Homo sapiens_hsa030201.45206338
24RNA degradation_Homo sapiens_hsa030181.45018514
25Nitrogen metabolism_Homo sapiens_hsa009101.44954312
26RNA transport_Homo sapiens_hsa030131.42285750
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41095372
28Antigen processing and presentation_Homo sapiens_hsa046121.22049137
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21775046
30Nucleotide excision repair_Homo sapiens_hsa034201.21448736
31Pyruvate metabolism_Homo sapiens_hsa006201.19125798
32Pyrimidine metabolism_Homo sapiens_hsa002401.18158279
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16112839
34Phototransduction_Homo sapiens_hsa047441.12432601
35Vitamin B6 metabolism_Homo sapiens_hsa007501.10460358
36Measles_Homo sapiens_hsa051621.02445949
37T cell receptor signaling pathway_Homo sapiens_hsa046600.99634835
38Huntingtons disease_Homo sapiens_hsa050160.99175071
39NF-kappa B signaling pathway_Homo sapiens_hsa040640.96441145
40Alzheimers disease_Homo sapiens_hsa050100.92519767
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91102833
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87763581
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87701929
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.85844334
45Spliceosome_Homo sapiens_hsa030400.82695448
46Folate biosynthesis_Homo sapiens_hsa007900.82604241
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81809102
48Collecting duct acid secretion_Homo sapiens_hsa049660.80411794
49Purine metabolism_Homo sapiens_hsa002300.79529360
50Butanoate metabolism_Homo sapiens_hsa006500.73684085
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73372720
52Fatty acid metabolism_Homo sapiens_hsa012120.72883404
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62737232
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60404898
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.60303002
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54744588
57Caffeine metabolism_Homo sapiens_hsa002320.54588635
58One carbon pool by folate_Homo sapiens_hsa006700.53963438
59Retinol metabolism_Homo sapiens_hsa008300.53687327
60Epstein-Barr virus infection_Homo sapiens_hsa051690.51366514
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50364531
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50075937
63Chemical carcinogenesis_Homo sapiens_hsa052040.49376557
64Fatty acid biosynthesis_Homo sapiens_hsa000610.48728883
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48544248
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47939511
67Fanconi anemia pathway_Homo sapiens_hsa034600.46237270
68Fatty acid degradation_Homo sapiens_hsa000710.46233754
69Herpes simplex infection_Homo sapiens_hsa051680.45385517
70Fatty acid elongation_Homo sapiens_hsa000620.44541081
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43857316
72Glutathione metabolism_Homo sapiens_hsa004800.43562799
73Legionellosis_Homo sapiens_hsa051340.43517323
74Metabolic pathways_Homo sapiens_hsa011000.42921966
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42866038
76Systemic lupus erythematosus_Homo sapiens_hsa053220.41834143
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41832386
78Cardiac muscle contraction_Homo sapiens_hsa042600.41388050
79Sulfur metabolism_Homo sapiens_hsa009200.40509655
80Olfactory transduction_Homo sapiens_hsa047400.40393576
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.40153953
82Homologous recombination_Homo sapiens_hsa034400.39321043
83Glycerolipid metabolism_Homo sapiens_hsa005610.39317552
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36217658
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35800315
86Serotonergic synapse_Homo sapiens_hsa047260.34943495
87Taste transduction_Homo sapiens_hsa047420.33830654
88Nicotine addiction_Homo sapiens_hsa050330.33094883
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31648828
90Peroxisome_Homo sapiens_hsa041460.31382809
91Salmonella infection_Homo sapiens_hsa051320.29537896
92Regulation of autophagy_Homo sapiens_hsa041400.28663640
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28241759
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27850289
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27081904
96Tryptophan metabolism_Homo sapiens_hsa003800.24695702
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24308205
98Alcoholism_Homo sapiens_hsa050340.23655483
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.22379308
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22370808

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