OSTCP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of natural killer cell differentiation (GO:0032825)9.22667692
2positive regulation of interleukin-17 production (GO:0032740)7.26361836
3positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)7.25422230
4regulation of natural killer cell differentiation (GO:0032823)6.27737160
5regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)6.16618262
6somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)5.65062615
7somatic diversification of immunoglobulins involved in immune response (GO:0002208)5.65062615
8isotype switching (GO:0045190)5.65062615
9positive regulation of interferon-gamma biosynthetic process (GO:0045078)5.08825512
10somatic recombination of immunoglobulin gene segments (GO:0016447)4.81620451
11positive regulation of natural killer cell activation (GO:0032816)4.73974403
12positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.63224410
13somatic diversification of immunoglobulins (GO:0016445)4.58039913
14regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.55027084
15regulation of mitotic spindle checkpoint (GO:1903504)4.50389983
16regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.50389983
17proteasome assembly (GO:0043248)4.36738686
18regulation of immunoglobulin secretion (GO:0051023)4.31362796
19CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.21706424
20response to pheromone (GO:0019236)4.14278444
21positive regulation of interleukin-10 production (GO:0032733)4.10810873
22regulation of isotype switching to IgG isotypes (GO:0048302)4.04164440
23positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.95846324
24DNA deamination (GO:0045006)3.92217375
25DNA double-strand break processing (GO:0000729)3.92088763
26protein K11-linked deubiquitination (GO:0035871)3.88359830
27positive regulation of isotype switching (GO:0045830)3.84281259
28positive regulation of natural killer cell mediated immunity (GO:0002717)3.78703789
29regulation of interferon-gamma biosynthetic process (GO:0045072)3.75511694
30replication fork processing (GO:0031297)3.67548155
31cytokine production involved in immune response (GO:0002367)3.65091451
32proline transport (GO:0015824)3.65073522
33positive regulation of DNA recombination (GO:0045911)3.61092140
34positive regulation of endothelial cell apoptotic process (GO:2000353)3.61073233
35positive regulation of cell cycle checkpoint (GO:1901978)3.58183422
36regulation of chronic inflammatory response (GO:0002676)3.56130872
37regulation of natural killer cell activation (GO:0032814)3.49976648
38positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)3.48351041
39production of molecular mediator of immune response (GO:0002440)3.39177586
40regulation of immunoglobulin production (GO:0002637)3.31046848
41regulation of interleukin-17 production (GO:0032660)3.23811059
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.21400097
43regulation of proton transport (GO:0010155)3.21170746
44negative regulation of T-helper cell differentiation (GO:0045623)3.19118095
45negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.19118095
46somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.16578117
47somatic cell DNA recombination (GO:0016444)3.16578117
48phospholipid homeostasis (GO:0055091)3.14820711
49water-soluble vitamin biosynthetic process (GO:0042364)3.13840472
50somatic diversification of immune receptors (GO:0002200)3.13301257
51positive regulation of chemokine biosynthetic process (GO:0045080)3.10770213
52kidney morphogenesis (GO:0060993)3.09961519
53nucleotide transmembrane transport (GO:1901679)3.06189919
54transcription elongation from RNA polymerase III promoter (GO:0006385)2.99283559
55termination of RNA polymerase III transcription (GO:0006386)2.99283559
56positive regulation of interleukin-12 production (GO:0032735)2.99071049
57negative regulation of acute inflammatory response (GO:0002674)2.98990422
58regulation of MHC class II biosynthetic process (GO:0045346)2.98797947
59positive regulation of histone H3-K4 methylation (GO:0051571)2.98305239
60GTP biosynthetic process (GO:0006183)2.97127329
61regulation of isotype switching (GO:0045191)2.96872442
62male meiosis I (GO:0007141)2.94975357
63regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)2.94220091
64regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.90167164
65regulation of natural killer cell mediated immunity (GO:0002715)2.88741562
66regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.88741562
67regulation of mitochondrial translation (GO:0070129)2.88407480
68inner mitochondrial membrane organization (GO:0007007)2.85795170
69double-strand break repair via homologous recombination (GO:0000724)2.83193198
70recombinational repair (GO:0000725)2.82878021
71positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)2.81550597
72transcription from mitochondrial promoter (GO:0006390)2.80526709
73regulation of hippo signaling (GO:0035330)2.79242914
74positive regulation of cell fate commitment (GO:0010455)2.78939985
75regulation of DNA recombination (GO:0000018)2.73191029
76T-helper cell differentiation (GO:0042093)2.72743614
77CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.72743614
78regulation of interleukin-10 production (GO:0032653)2.70980498
79rRNA modification (GO:0000154)2.70865766
80fucose catabolic process (GO:0019317)2.70456976
81L-fucose metabolic process (GO:0042354)2.70456976
82L-fucose catabolic process (GO:0042355)2.70456976
83exogenous drug catabolic process (GO:0042738)2.68910426
84B cell activation involved in immune response (GO:0002312)2.67198121
85positive regulation of T cell migration (GO:2000406)2.65005645
86regulation of acyl-CoA biosynthetic process (GO:0050812)2.64432566
87positive regulation of tissue remodeling (GO:0034105)2.64077508
88regulation of cofactor metabolic process (GO:0051193)2.63155290
89regulation of coenzyme metabolic process (GO:0051196)2.63155290
90regulation of centriole replication (GO:0046599)2.62888801
91estrogen biosynthetic process (GO:0006703)2.62498281
92pseudouridine synthesis (GO:0001522)2.60891659
93synapsis (GO:0007129)2.60509964
94positive regulation of immunoglobulin production (GO:0002639)2.59146452
95inositol phosphate catabolic process (GO:0071545)2.58099150
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.57823971
97protein neddylation (GO:0045116)2.57706478
98termination of RNA polymerase I transcription (GO:0006363)2.55846643
99positive regulation of activated T cell proliferation (GO:0042104)2.54118672
100reflex (GO:0060004)2.53180097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.80620015
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.79530883
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.49613447
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06509836
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.02834451
6VDR_22108803_ChIP-Seq_LS180_Human2.85492080
7ZNF274_21170338_ChIP-Seq_K562_Hela2.77704919
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.68173225
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.63357308
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.60616752
11GBX2_23144817_ChIP-Seq_PC3_Human2.54945207
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.44830308
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44059294
14EWS_26573619_Chip-Seq_HEK293_Human2.29442764
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27800763
16TAF15_26573619_Chip-Seq_HEK293_Human2.26052276
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.20571211
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12823339
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12074883
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.10975480
21PCGF2_27294783_Chip-Seq_NPCs_Mouse2.02760415
22TP53_22573176_ChIP-Seq_HFKS_Human2.01834576
23P300_19829295_ChIP-Seq_ESCs_Human1.98654396
24ELK1_19687146_ChIP-ChIP_HELA_Human1.94378179
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89914439
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75988045
27GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.70877174
28IGF1R_20145208_ChIP-Seq_DFB_Human1.67139910
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64129431
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62397568
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59045699
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54264940
33VDR_23849224_ChIP-Seq_CD4+_Human1.52243768
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50619321
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46819698
36FUS_26573619_Chip-Seq_HEK293_Human1.45818902
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45633948
38CBP_20019798_ChIP-Seq_JUKART_Human1.45633948
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41445911
40NANOG_19829295_ChIP-Seq_ESCs_Human1.40135350
41SOX2_19829295_ChIP-Seq_ESCs_Human1.40135350
42TCF4_22108803_ChIP-Seq_LS180_Human1.37054897
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.36485982
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34342671
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.32632725
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32120954
47BCAT_22108803_ChIP-Seq_LS180_Human1.30293520
48GATA1_22025678_ChIP-Seq_K562_Human1.28877668
49ER_23166858_ChIP-Seq_MCF-7_Human1.28726819
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28493619
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28217063
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.27430279
53MYC_18940864_ChIP-ChIP_HL60_Human1.26463791
54STAT3_23295773_ChIP-Seq_U87_Human1.25922265
55TCF4_23295773_ChIP-Seq_U87_Human1.25296915
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24915344
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23856729
58SMAD4_21799915_ChIP-Seq_A2780_Human1.20639447
59SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19179367
60GATA3_26560356_Chip-Seq_TH2_Human1.18211138
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17451909
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17332295
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17203143
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.14631832
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13733328
66STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13047878
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12444219
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12362002
69HTT_18923047_ChIP-ChIP_STHdh_Human1.10815979
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09982204
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.09424700
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08581241
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.07548956
74NMYC_18555785_Chip-Seq_ESCs_Mouse1.07444112
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07236705
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06123757
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05517477
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05340066
79FOXP3_21729870_ChIP-Seq_TREG_Human1.05160336
80P300_18555785_Chip-Seq_ESCs_Mouse1.04631744
81AR_25329375_ChIP-Seq_VCAP_Human1.04486808
82RUNX2_22187159_ChIP-Seq_PCA_Human1.03960501
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03679968
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03679968
85P53_22387025_ChIP-Seq_ESCs_Mouse1.02522571
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.01945407
87JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01690776
88SOX2_18555785_Chip-Seq_ESCs_Mouse1.01051351
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00449249
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98533552
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98269213
92TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97586169
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96870570
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96387195
95E2F1_18555785_Chip-Seq_ESCs_Mouse0.96291318
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.96104891
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94991965
98CMYC_18555785_Chip-Seq_ESCs_Mouse0.94897878
99OCT4_18555785_Chip-Seq_ESCs_Mouse0.93894915
100SRF_21415370_ChIP-Seq_HL-1_Mouse0.92275756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland4.52245033
2MP0000569_abnormal_digit_pigmentation4.25265006
3MP0008877_abnormal_DNA_methylation3.74815193
4MP0004742_abnormal_vestibular_system3.31610356
5MP0008872_abnormal_physiological_respon2.99402920
6MP0001873_stomach_inflammation2.52595642
7MP0001984_abnormal_olfaction2.52295042
8MP0001968_abnormal_touch/_nociception2.49567693
9MP0010386_abnormal_urinary_bladder2.45289341
10MP0005379_endocrine/exocrine_gland_phen2.44221918
11MP0002102_abnormal_ear_morphology2.29040711
12MP0002736_abnormal_nociception_after2.27355731
13MP0002837_dystrophic_cardiac_calcinosis2.24508117
14MP0006082_CNS_inflammation2.01578091
15MP0008875_abnormal_xenobiotic_pharmacok1.97562880
16MP0005408_hypopigmentation1.96655103
17MP0003195_calcinosis1.93298369
18MP0003787_abnormal_imprinting1.93070642
19MP0002254_reproductive_system_inflammat1.92914168
20MP0010234_abnormal_vibrissa_follicle1.90730824
21MP0005174_abnormal_tail_pigmentation1.88348590
22MP0003890_abnormal_embryonic-extraembry1.87609898
23MP0001835_abnormal_antigen_presentation1.87289000
24MP0005310_abnormal_salivary_gland1.86015434
25MP0008057_abnormal_DNA_replication1.78954546
26MP0005645_abnormal_hypothalamus_physiol1.64328038
27MP0003329_amyloid_beta_deposits1.64106238
28MP0005551_abnormal_eye_electrophysiolog1.54914362
29MP0002876_abnormal_thyroid_physiology1.52825487
30MP0002163_abnormal_gland_morphology1.52396996
31MP0006072_abnormal_retinal_apoptosis1.49637890
32MP0003646_muscle_fatigue1.46934113
33MP0002009_preneoplasia1.45774735
34MP0000427_abnormal_hair_cycle1.44080484
35MP0009745_abnormal_behavioral_response1.41017857
36MP0008789_abnormal_olfactory_epithelium1.35208885
37MP0009840_abnormal_foam_cell1.34819945
38MP0003045_fibrosis1.33745500
39MP0005075_abnormal_melanosome_morpholog1.31749964
40MP0000685_abnormal_immune_system1.31040402
41MP0003693_abnormal_embryo_hatching1.30317997
42MP0000372_irregular_coat_pigmentation1.29042429
43MP0002928_abnormal_bile_duct1.27107040
44MP0000538_abnormal_urinary_bladder1.25540144
45MP0002166_altered_tumor_susceptibility1.22190240
46MP0003943_abnormal_hepatobiliary_system1.20041714
47MP0003567_abnormal_fetal_cardiomyocyte1.16567254
48MP0008775_abnormal_heart_ventricle1.16424266
49MP0004133_heterotaxia1.16034041
50MP0001501_abnormal_sleep_pattern1.13613002
51MP0010678_abnormal_skin_adnexa1.12227761
52MP0000604_amyloidosis1.11940447
53MP0001986_abnormal_taste_sensitivity1.10595823
54MP0004215_abnormal_myocardial_fiber1.10218615
55MP0010329_abnormal_lipoprotein_level1.09231286
56MP0005167_abnormal_blood-brain_barrier1.06654404
57MP0003786_premature_aging1.04977650
58MP0002638_abnormal_pupillary_reflex1.02850483
59MP0004381_abnormal_hair_follicle1.01908842
60MP0000015_abnormal_ear_pigmentation1.01384279
61MP0001529_abnormal_vocalization1.01130669
62MP0001486_abnormal_startle_reflex0.99503901
63MP0005387_immune_system_phenotype0.98210962
64MP0001790_abnormal_immune_system0.98210962
65MP0005410_abnormal_fertilization0.97243542
66MP0002735_abnormal_chemical_nociception0.94564518
67MP0002006_tumorigenesis0.93722839
68MP0002138_abnormal_hepatobiliary_system0.92988121
69MP0005253_abnormal_eye_physiology0.88558931
70MP0002229_neurodegeneration0.88399361
71MP0003136_yellow_coat_color0.85321521
72MP0005389_reproductive_system_phenotype0.83854566
73MP0003718_maternal_effect0.82769216
74MP0000383_abnormal_hair_follicle0.82726770
75MP0001919_abnormal_reproductive_system0.82320798
76MP0003937_abnormal_limbs/digits/tail_de0.81992144
77MP0002693_abnormal_pancreas_physiology0.79255957
78MP0008007_abnormal_cellular_replicative0.78216965
79MP0005084_abnormal_gallbladder_morpholo0.77908616
80MP0001485_abnormal_pinna_reflex0.74861812
81MP0002272_abnormal_nervous_system0.74420483
82MP0000631_abnormal_neuroendocrine_gland0.74267101
83MP0001905_abnormal_dopamine_level0.71743892
84MP0006036_abnormal_mitochondrial_physio0.71621946
85MP0003936_abnormal_reproductive_system0.70828820
86MP0003633_abnormal_nervous_system0.69970677
87MP0005636_abnormal_mineral_homeostasis0.68924401
88MP0002332_abnormal_exercise_endurance0.65494382
89MP0008058_abnormal_DNA_repair0.64669303
90MP0004043_abnormal_pH_regulation0.64487864
91MP0002168_other_aberrant_phenotype0.64482988
92MP0005671_abnormal_response_to0.63452419
93MP0001661_extended_life_span0.62378216
94MP0001188_hyperpigmentation0.62183088
95MP0001243_abnormal_dermal_layer0.62166837
96MP0000639_abnormal_adrenal_gland0.61244952
97MP0005367_renal/urinary_system_phenotyp0.60995149
98MP0000516_abnormal_urinary_system0.60995149
99MP0004019_abnormal_vitamin_homeostasis0.60247253
100MP0002184_abnormal_innervation0.60110786

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)7.38836715
2Chronic diarrhea (HP:0002028)6.02085409
3Increased IgM level (HP:0003496)5.15381070
4Abnormality of incisor morphology (HP:0011063)4.71142130
5Gaze-evoked nystagmus (HP:0000640)3.43787562
6IgA deficiency (HP:0002720)3.43756694
7Thyroiditis (HP:0100646)3.41328152
8Abdominal situs inversus (HP:0003363)3.24772626
9Abnormality of abdominal situs (HP:0011620)3.24772626
10Multiple enchondromatosis (HP:0005701)3.04732710
11Curly hair (HP:0002212)2.95359919
12Bilateral sensorineural hearing impairment (HP:0008619)2.75935780
13Intestinal atresia (HP:0011100)2.70927972
14Inflammation of the large intestine (HP:0002037)2.58490763
15Abnormality of the nasal septum (HP:0000419)2.58273803
16Progressive macrocephaly (HP:0004481)2.55987740
17Progressive inability to walk (HP:0002505)2.54367103
18IgG deficiency (HP:0004315)2.53348600
19Pancreatic cysts (HP:0001737)2.49444723
20Hematochezia (HP:0002573)2.48993258
21Abnormality of T cell physiology (HP:0011840)2.45222117
22Asplenia (HP:0001746)2.43346425
23Fatigue (HP:0012378)2.42954838
24Absent hand (HP:0004050)2.42031792
25Volvulus (HP:0002580)2.41076660
26Aplasia/Hypoplasia of the fovea (HP:0008060)2.35678702
27Hypoplasia of the fovea (HP:0007750)2.35678702
28Aplasia/Hypoplasia of the spleen (HP:0010451)2.34974056
29Aqueductal stenosis (HP:0002410)2.34630681
30Abnormality of the incisor (HP:0000676)2.34586566
31Nephronophthisis (HP:0000090)2.31616033
32Acute necrotizing encephalopathy (HP:0006965)2.28490018
33Dysmetric saccades (HP:0000641)2.26306939
34Abnormal pupillary function (HP:0007686)2.26150944
35Gastrointestinal inflammation (HP:0004386)2.24482707
36Congenital stationary night blindness (HP:0007642)2.21596999
37True hermaphroditism (HP:0010459)2.21186026
38Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16987432
39Abnormality of T cells (HP:0002843)2.12760406
40Renal cortical cysts (HP:0000803)2.12644386
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.07434530
42Megalencephaly (HP:0001355)2.03931618
43Progressive microcephaly (HP:0000253)1.99631410
44Aplasia/Hypoplasia of the macula (HP:0008059)1.98970073
45Abnormality of methionine metabolism (HP:0010901)1.98793425
46Abnormal albumin level (HP:0012116)1.96987233
47Hypoalbuminemia (HP:0003073)1.96987233
48Neutropenia (HP:0001875)1.96748953
49Delayed puberty (HP:0000823)1.96472246
50Type II lissencephaly (HP:0007260)1.94181307
51Chin dimple (HP:0010751)1.93542113
52Abnormality of vitamin B metabolism (HP:0004340)1.92459115
53Abnormality of B cell number (HP:0010975)1.90651883
54Cubitus valgus (HP:0002967)1.90299935
55Methylmalonic aciduria (HP:0012120)1.90184755
56Dyskinesia (HP:0100660)1.89848472
57Sclerocornea (HP:0000647)1.89794174
58Acute encephalopathy (HP:0006846)1.89577550
59Abnormality of the renal medulla (HP:0100957)1.87926834
60Pancreatic fibrosis (HP:0100732)1.87824638
61Aplasia/Hypoplasia of the uvula (HP:0010293)1.87277085
62Abnormality of midbrain morphology (HP:0002418)1.86280581
63Molar tooth sign on MRI (HP:0002419)1.86280581
64Attenuation of retinal blood vessels (HP:0007843)1.86227882
65Abnormality of the ileum (HP:0001549)1.86106634
66B lymphocytopenia (HP:0010976)1.85449850
67Abnormality of aromatic amino acid family metabolism (HP:0004338)1.84079025
68Aplasia/Hypoplasia affecting the retina (HP:0008061)1.83934878
69Concave nail (HP:0001598)1.83019100
70Abnormality of the parathyroid morphology (HP:0011766)1.82811301
71Methylmalonic acidemia (HP:0002912)1.81989079
72Medial flaring of the eyebrow (HP:0010747)1.81882502
73Optic disc pallor (HP:0000543)1.81262990
74Severe combined immunodeficiency (HP:0004430)1.81006467
75Abnormality of the renal cortex (HP:0011035)1.80647810
76Meckel diverticulum (HP:0002245)1.78681461
77Poor head control (HP:0002421)1.78512769
78Hypobetalipoproteinemia (HP:0003563)1.78424852
79Cerebral hemorrhage (HP:0001342)1.77706351
80Abnormal rod and cone electroretinograms (HP:0008323)1.76080874
81Increased CSF lactate (HP:0002490)1.74456748
82Polydipsia (HP:0001959)1.74056350
83Abnormal drinking behavior (HP:0030082)1.74056350
84Abnormality of the fovea (HP:0000493)1.73977415
85Neoplasm of the adrenal cortex (HP:0100641)1.73747006
86Hydroxyprolinuria (HP:0003080)1.72621566
87Abnormality of proline metabolism (HP:0010907)1.72621566
88Colon cancer (HP:0003003)1.72129454
89Chronic hepatic failure (HP:0100626)1.72092624
90Large for gestational age (HP:0001520)1.70163903
91Scrotal hypoplasia (HP:0000046)1.69868185
92Increased serum pyruvate (HP:0003542)1.68692312
93Small hand (HP:0200055)1.68347023
94Abnormal mitochondria in muscle tissue (HP:0008316)1.66739308
95Male pseudohermaphroditism (HP:0000037)1.66596031
96Gonadal dysgenesis (HP:0000133)1.66545345
97Short chin (HP:0000331)1.65801247
98Central scotoma (HP:0000603)1.65374429
99Limb dystonia (HP:0002451)1.64015879
100Congenital sensorineural hearing impairment (HP:0008527)1.63082094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.33906563
2EIF2AK33.93088524
3MST43.11456509
4PAK32.85011623
5PAK62.64558525
6PDK22.56637665
7PBK2.51707937
8MKNK22.42990581
9WNK32.30997427
10FGFR22.04585900
11KSR12.04535443
12BMPR1B1.94205439
13BRSK21.86988028
14TSSK61.84139028
15PLK41.82502341
16TRIM281.81249840
17MAP3K41.74617627
18STK391.72522269
19CAMKK21.71860557
20ADRBK21.66081376
21ACVR1B1.62030958
22KSR21.60320691
23PINK11.57613968
24EIF2AK11.54356107
25OXSR11.48016984
26PNCK1.43220027
27PLK31.41903491
28GRK11.41585196
29RAF11.37000760
30BRD41.33392733
31NEK11.33225233
32MKNK11.26862231
33MAP2K71.20075460
34NLK1.19609724
35FGFR11.17488479
36CSNK1G11.15235879
37NME11.14428776
38PRKAA21.10082514
39CASK1.06100961
40ZAK1.04886887
41STK160.97140274
42PHKG20.95609433
43PHKG10.95609433
44WNK40.92616209
45BCR0.85287584
46ERBB30.81065176
47AKT30.78934657
48ERBB40.78640705
49EIF2AK20.75948335
50CSNK1G30.72016790
51TNK20.71339732
52TRPM70.70093771
53SIK30.68795653
54STK40.67017506
55CSNK1A1L0.63806790
56PLK20.62918491
57MAPK130.62261413
58RPS6KA40.62045881
59MAPK110.60387451
60IKBKB0.59175343
61PRKCG0.58611023
62VRK10.58372933
63PRKCE0.57508623
64BMPR20.54165139
65CSNK1G20.52345980
66TTK0.50977923
67CSNK1A10.50386450
68WEE10.50159510
69NUAK10.49574744
70MAP4K20.49093238
71FGFR30.45713123
72NEK60.45426567
73ADRBK10.43966854
74MAP2K10.43174067
75CHUK0.41272798
76PLK10.38167671
77DAPK20.38090638
78STK30.37378115
79TEC0.37086932
80CDK30.37016283
81CSNK1D0.36491743
82SGK10.34992116
83TGFBR10.34916384
84CLK10.32627783
85INSRR0.32341116
86ALK0.31623019
87SCYL20.30772356
88PRKCZ0.30719415
89DYRK20.30058537
90CAMK2D0.29061510
91PRKCI0.27566914
92PTK2B0.27287685
93IGF1R0.27038719
94PRKCB0.26365544
95PRKG10.25589195
96CAMK40.25229938
97ATM0.25140363
98MAP3K120.24618654
99JAK10.24579720
100CHEK10.24180592

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.86784651
2Asthma_Homo sapiens_hsa053103.14183755
3Proteasome_Homo sapiens_hsa030502.86521736
4Allograft rejection_Homo sapiens_hsa053302.61477229
5Autoimmune thyroid disease_Homo sapiens_hsa053202.57087053
6RNA polymerase_Homo sapiens_hsa030202.46326203
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.37082683
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.36938828
9Protein export_Homo sapiens_hsa030602.31474421
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.31087119
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29364767
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26529810
13Homologous recombination_Homo sapiens_hsa034402.21511251
14Primary immunodeficiency_Homo sapiens_hsa053402.03983585
15Phototransduction_Homo sapiens_hsa047441.97142594
16Nitrogen metabolism_Homo sapiens_hsa009101.96905390
17Caffeine metabolism_Homo sapiens_hsa002321.94234267
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.78643345
19One carbon pool by folate_Homo sapiens_hsa006701.75531386
20Propanoate metabolism_Homo sapiens_hsa006401.69744119
21RNA transport_Homo sapiens_hsa030131.55911034
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.51589408
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45590965
24RNA degradation_Homo sapiens_hsa030181.42249784
25Oxidative phosphorylation_Homo sapiens_hsa001901.40155175
26Non-homologous end-joining_Homo sapiens_hsa034501.39167909
27Linoleic acid metabolism_Homo sapiens_hsa005911.28840839
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.27408578
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24420589
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.23904195
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.21968226
32Parkinsons disease_Homo sapiens_hsa050121.20930780
33Fanconi anemia pathway_Homo sapiens_hsa034601.19738036
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13198962
35Taste transduction_Homo sapiens_hsa047421.11903329
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10928108
37Basal transcription factors_Homo sapiens_hsa030221.10731729
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09113932
39Folate biosynthesis_Homo sapiens_hsa007901.03259105
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02269943
41Peroxisome_Homo sapiens_hsa041461.01804947
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01124994
43Selenocompound metabolism_Homo sapiens_hsa004500.94996050
44Collecting duct acid secretion_Homo sapiens_hsa049660.93761572
45T cell receptor signaling pathway_Homo sapiens_hsa046600.93043279
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92570389
47Butanoate metabolism_Homo sapiens_hsa006500.91731811
48Circadian rhythm_Homo sapiens_hsa047100.89122343
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.87608508
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83785586
51Mineral absorption_Homo sapiens_hsa049780.81865288
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77464694
53Sphingolipid metabolism_Homo sapiens_hsa006000.76407568
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73318609
55Fat digestion and absorption_Homo sapiens_hsa049750.68089429
56Rheumatoid arthritis_Homo sapiens_hsa053230.67780295
57Sulfur metabolism_Homo sapiens_hsa009200.67083802
58Retinol metabolism_Homo sapiens_hsa008300.66969454
59Hematopoietic cell lineage_Homo sapiens_hsa046400.63406478
60Fatty acid metabolism_Homo sapiens_hsa012120.61299155
61beta-Alanine metabolism_Homo sapiens_hsa004100.60771361
62Arginine biosynthesis_Homo sapiens_hsa002200.60573009
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60509339
64Vitamin digestion and absorption_Homo sapiens_hsa049770.59999925
65mRNA surveillance pathway_Homo sapiens_hsa030150.57466487
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55952225
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55901480
68Chemical carcinogenesis_Homo sapiens_hsa052040.54638810
69Spliceosome_Homo sapiens_hsa030400.54398923
70Purine metabolism_Homo sapiens_hsa002300.53549160
71Pyrimidine metabolism_Homo sapiens_hsa002400.50618217
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50518188
73Fatty acid elongation_Homo sapiens_hsa000620.50082602
74Metabolic pathways_Homo sapiens_hsa011000.49053484
75Alzheimers disease_Homo sapiens_hsa050100.48833252
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48330471
77Glycerolipid metabolism_Homo sapiens_hsa005610.47230283
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46501751
79Huntingtons disease_Homo sapiens_hsa050160.46489691
80p53 signaling pathway_Homo sapiens_hsa041150.45161318
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43667959
82TGF-beta signaling pathway_Homo sapiens_hsa043500.43505113
83Arachidonic acid metabolism_Homo sapiens_hsa005900.43246050
84Tryptophan metabolism_Homo sapiens_hsa003800.43207522
85Pyruvate metabolism_Homo sapiens_hsa006200.41750928
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39683262
87Ether lipid metabolism_Homo sapiens_hsa005650.39150249
88Arginine and proline metabolism_Homo sapiens_hsa003300.38824170
89Type I diabetes mellitus_Homo sapiens_hsa049400.37090424
90Glucagon signaling pathway_Homo sapiens_hsa049220.36121833
91Steroid biosynthesis_Homo sapiens_hsa001000.35017247
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33434980
93Serotonergic synapse_Homo sapiens_hsa047260.32622787
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32466310
95Calcium signaling pathway_Homo sapiens_hsa040200.30994428
96Legionellosis_Homo sapiens_hsa051340.30294185
97Nicotine addiction_Homo sapiens_hsa050330.29662000
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29480339
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.29305009
100Cardiac muscle contraction_Homo sapiens_hsa042600.24972233

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