OSTF1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)9.75558858
2pyrimidine ribonucleoside catabolic process (GO:0046133)9.52383179
3Arp2/3 complex-mediated actin nucleation (GO:0034314)5.47788142
4cellular response to interleukin-15 (GO:0071350)5.11930071
5regulation of B cell receptor signaling pathway (GO:0050855)5.02874995
6positive regulation of natural killer cell mediated immunity (GO:0002717)5.01004684
7actin nucleation (GO:0045010)4.95735238
8pyrimidine nucleoside catabolic process (GO:0046135)4.94963025
9positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.90836716
10positive regulation of interleukin-8 secretion (GO:2000484)4.80118470
11T cell migration (GO:0072678)4.74368046
12negative regulation of viral genome replication (GO:0045071)4.59973490
13positive regulation of natural killer cell differentiation (GO:0032825)4.54177811
14negative regulation of T cell apoptotic process (GO:0070233)4.39632024
15regulation of natural killer cell mediated immunity (GO:0002715)4.35746725
16regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.35746725
17response to interleukin-15 (GO:0070672)4.33677916
18regulation of activation of Janus kinase activity (GO:0010533)4.22047009
19positive T cell selection (GO:0043368)4.20527704
20negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.11723736
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.10671822
22regulation of T cell receptor signaling pathway (GO:0050856)4.07150117
23positive regulation of gamma-delta T cell activation (GO:0046645)4.03865321
24positive thymic T cell selection (GO:0045059)4.03428800
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.97329664
26negative T cell selection (GO:0043383)3.96574098
27positive regulation of T cell chemotaxis (GO:0010820)3.91439789
28regulation of T cell chemotaxis (GO:0010819)3.91439789
29regulation of interleukin-8 secretion (GO:2000482)3.89630370
30regulation of lymphocyte chemotaxis (GO:1901623)3.75884444
31antigen processing and presentation via MHC class Ib (GO:0002475)3.75776173
32positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.70365303
33regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.68412882
34cytolysis (GO:0019835)3.67933052
35negative regulation of mast cell activation (GO:0033004)3.64463484
36positive regulation of B cell differentiation (GO:0045579)3.64292633
37eosinophil chemotaxis (GO:0048245)3.58252269
38regulation of chronic inflammatory response (GO:0002676)3.57325841
39positive regulation of calcium-mediated signaling (GO:0050850)3.55607093
40negative regulation of T cell receptor signaling pathway (GO:0050860)3.53296601
41proteasome assembly (GO:0043248)3.48482653
42positive regulation of tolerance induction (GO:0002645)3.45505923
43thymic T cell selection (GO:0045061)3.44594462
44regulation of leukocyte mediated cytotoxicity (GO:0001910)3.44155543
45macrophage chemotaxis (GO:0048246)3.42938260
46negative regulation by host of viral transcription (GO:0043922)3.40620518
47regulation of gamma-delta T cell differentiation (GO:0045586)3.39250697
48positive regulation of monocyte chemotaxis (GO:0090026)3.39072581
49regulation of T cell apoptotic process (GO:0070232)3.37313662
50T cell selection (GO:0045058)3.35250015
51regulation of T cell tolerance induction (GO:0002664)3.25121602
52regulation of viral genome replication (GO:0045069)3.24253533
53eosinophil migration (GO:0072677)3.23800941
54positive regulation of cell killing (GO:0031343)3.23030902
55negative thymic T cell selection (GO:0045060)3.21457617
56lymphocyte chemotaxis (GO:0048247)3.16797797
57pyrimidine-containing compound catabolic process (GO:0072529)3.16611024
58purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.15507832
59regulation of natural killer cell differentiation (GO:0032823)3.13592538
60T cell receptor signaling pathway (GO:0050852)3.12151511
61sequestering of actin monomers (GO:0042989)3.11386576
62positive regulation of defense response to virus by host (GO:0002230)3.10614733
63T cell costimulation (GO:0031295)3.10332454
64lymphocyte costimulation (GO:0031294)3.06437080
65mast cell activation involved in immune response (GO:0002279)3.06206180
66mast cell degranulation (GO:0043303)3.06206180
67regulation of cell killing (GO:0031341)3.05499044
68antigen processing and presentation of endogenous antigen (GO:0019883)3.03401024
69positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.02645985
70positive regulation of T cell apoptotic process (GO:0070234)3.01769274
71regulation of B cell differentiation (GO:0045577)3.01517170
72negative regulation of lymphocyte apoptotic process (GO:0070229)2.99604913
73immunoglobulin mediated immune response (GO:0016064)2.96287182
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.92301600
75positive regulation of alpha-beta T cell proliferation (GO:0046641)2.90954516
76lymphocyte migration (GO:0072676)2.90458792
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90120163
78deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89688050
79negative regulation of stress fiber assembly (GO:0051497)2.87601205
80regulation of gamma-delta T cell activation (GO:0046643)2.86692598
81B cell mediated immunity (GO:0019724)2.84618974
82regulation of interleukin-2 biosynthetic process (GO:0045076)2.83010525
83mast cell activation (GO:0045576)2.82437465
84positive regulation of lymphocyte migration (GO:2000403)2.81130617
85regulation of regulatory T cell differentiation (GO:0045589)2.80602497
86antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.78564282
87iron-sulfur cluster assembly (GO:0016226)2.76276103
88metallo-sulfur cluster assembly (GO:0031163)2.76276103
89regulation of tolerance induction (GO:0002643)2.74988557
90antigen receptor-mediated signaling pathway (GO:0050851)2.74743135
91heterotypic cell-cell adhesion (GO:0034113)2.74588122
92negative regulation of ligase activity (GO:0051352)2.72185919
93negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72185919
94positive regulation of granulocyte differentiation (GO:0030854)2.70152287
95negative regulation of viral process (GO:0048525)2.69274029
96regulation of cellular extravasation (GO:0002691)2.68658448
97cytidine deamination (GO:0009972)10.6413878
98cytidine metabolic process (GO:0046087)10.6413878
99cytidine catabolic process (GO:0006216)10.6413878
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509110.3457922

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.70266413
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.66105367
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.59072991
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.41205110
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.06499473
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.86407169
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.79110410
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.58851446
9MYB_26560356_Chip-Seq_TH2_Human3.16496979
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.86124239
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.74031375
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67805282
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.61888895
14RUNX_20019798_ChIP-Seq_JUKART_Human2.48783716
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44543664
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.20290880
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17536179
18GATA3_27048872_Chip-Seq_THYMUS_Human2.10005652
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.08308133
20VDR_23849224_ChIP-Seq_CD4+_Human2.03641345
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.01142252
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.00817713
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.96921897
24GATA3_26560356_Chip-Seq_TH2_Human1.94541978
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.90399974
26MYB_26560356_Chip-Seq_TH1_Human1.88319088
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71578088
28UTX_26944678_Chip-Seq_JUKART_Human1.68125407
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.67469617
30HTT_18923047_ChIP-ChIP_STHdh_Human1.63495995
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.62626312
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56067827
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52619822
34MAF_26560356_Chip-Seq_TH2_Human1.50976627
35RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.46463435
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.46444345
37MAF_26560356_Chip-Seq_TH1_Human1.45723323
38VDR_22108803_ChIP-Seq_LS180_Human1.40773265
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38653925
40SPI1_23547873_ChIP-Seq_NB4_Human1.36667335
41PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.35780291
42ELK1_19687146_ChIP-ChIP_HELA_Human1.35521897
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34681040
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31845459
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31548080
46BCL6_27268052_Chip-Seq_Bcells_Human1.28489995
47FOXP3_21729870_ChIP-Seq_TREG_Human1.28411878
48TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.26971856
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25795389
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25655021
51EZH2_22144423_ChIP-Seq_EOC_Human1.24186510
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.22772905
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21723815
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.21631915
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17533737
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17475231
57SCL_19346495_ChIP-Seq_HPC-7_Human1.17036410
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.11898138
59PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08701477
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.08002197
61FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04759740
62NCOR_22424771_ChIP-Seq_293T_Human1.04270989
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00961343
64RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99597289
65IGF1R_20145208_ChIP-Seq_DFB_Human0.98694047
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97933850
67CTCF_20526341_ChIP-Seq_ESCs_Human0.95698800
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94129720
69CIITA_25753668_ChIP-Seq_RAJI_Human0.93710198
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92316940
71HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90300594
72AR_20517297_ChIP-Seq_VCAP_Human0.88946430
73GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87844646
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87820975
75BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87032607
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85383501
77PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85303194
78ZNF274_21170338_ChIP-Seq_K562_Hela0.83649515
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83007298
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82927463
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82014759
82NFE2_27457419_Chip-Seq_LIVER_Mouse0.81512929
83ERG_20517297_ChIP-Seq_VCAP_Human0.81159419
84NANOG_20526341_ChIP-Seq_ESCs_Human0.80525229
85EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.80398590
86IRF1_19129219_ChIP-ChIP_H3396_Human0.80051836
87MYC_19829295_ChIP-Seq_ESCs_Human0.79484758
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78976238
89RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77813425
90TAF2_19829295_ChIP-Seq_ESCs_Human0.77456704
91RUNX1_22412390_ChIP-Seq_EML_Mouse0.75380513
92GATA3_26560356_Chip-Seq_TH1_Human0.75275035
93STAT1_20625510_ChIP-Seq_HELA_Human0.75115600
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74361728
95GATA6_21074721_ChIP-Seq_CACO-2_Human0.73854152
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73452259
97CBP_20019798_ChIP-Seq_JUKART_Human0.73383412
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.73383412
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.73148267
100SPI1_23127762_ChIP-Seq_K562_Human0.72926001

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.01321269
2MP0003763_abnormal_thymus_physiology4.67665842
3MP0009785_altered_susceptibility_to3.60441022
4MP0002166_altered_tumor_susceptibility3.07643891
5MP0005000_abnormal_immune_tolerance3.01327935
6MP0001873_stomach_inflammation2.99722425
7MP0001835_abnormal_antigen_presentation2.94424872
8MP0001790_abnormal_immune_system2.77017785
9MP0005387_immune_system_phenotype2.77017785
10MP0000685_abnormal_immune_system2.70137338
11MP0001800_abnormal_humoral_immune2.65620272
12MP0002006_tumorigenesis2.64149517
13MP0005025_abnormal_response_to2.63599825
14MP0003646_muscle_fatigue2.53495656
15MP0009333_abnormal_splenocyte_physiolog2.49934874
16MP0002723_abnormal_immune_serum2.46428853
17MP0002420_abnormal_adaptive_immunity2.43409235
18MP0002933_joint_inflammation2.41928809
19MP0004147_increased_porphyrin_level2.40707857
20MP0001819_abnormal_immune_cell2.34838782
21MP0002148_abnormal_hypersensitivity_rea2.28657705
22MP0006082_CNS_inflammation2.22428596
23MP0003866_abnormal_defecation2.13389248
24MP0002452_abnormal_antigen_presenting2.05315784
25MP0002405_respiratory_system_inflammati1.98635873
26MP0003448_altered_tumor_morphology1.98164023
27MP0006072_abnormal_retinal_apoptosis1.96155755
28MP0003436_decreased_susceptibility_to1.89703486
29MP0002398_abnormal_bone_marrow1.86297088
30MP0000716_abnormal_immune_system1.79717022
31MP0010155_abnormal_intestine_physiology1.79540953
32MP0001845_abnormal_inflammatory_respons1.70929548
33MP0000703_abnormal_thymus_morphology1.70919467
34MP0002009_preneoplasia1.66847976
35MP0002722_abnormal_immune_system1.64433259
36MP0003724_increased_susceptibility_to1.64384209
37MP0002419_abnormal_innate_immunity1.61291325
38MP0000689_abnormal_spleen_morphology1.59169800
39MP0004947_skin_inflammation1.49055589
40MP0003045_fibrosis1.46760748
41MP0000858_altered_metastatic_potential1.42054138
42MP0005083_abnormal_biliary_tract1.41742768
43MP0002429_abnormal_blood_cell1.37868195
44MP0003786_premature_aging1.34898087
45MP0005464_abnormal_platelet_physiology1.33232588
46MP0001533_abnormal_skeleton_physiology1.31692954
47MP0001542_abnormal_bone_strength1.23683000
48MP0001243_abnormal_dermal_layer1.15306956
49MP0004381_abnormal_hair_follicle1.11605667
50MP0003191_abnormal_cellular_cholesterol1.10974840
51MP0001501_abnormal_sleep_pattern1.09582851
52MP0009764_decreased_sensitivity_to1.08120075
53MP0009763_increased_sensitivity_to1.03937017
54MP0001919_abnormal_reproductive_system1.02246345
55MP0004145_abnormal_muscle_electrophysio1.02195976
56MP0008469_abnormal_protein_level0.96819008
57MP0009384_cardiac_valve_regurgitation0.94452654
58MP0003252_abnormal_bile_duct0.90965400
59MP0002693_abnormal_pancreas_physiology0.90903485
60MP0008877_abnormal_DNA_methylation0.89632084
61MP0008875_abnormal_xenobiotic_pharmacok0.88752658
62MP0005310_abnormal_salivary_gland0.86612198
63MP0001853_heart_inflammation0.85414865
64MP0002019_abnormal_tumor_incidence0.84640348
65MP0000383_abnormal_hair_follicle0.81879776
66MP0000604_amyloidosis0.81185423
67MP0003880_abnormal_central_pattern0.80668571
68MP0000465_gastrointestinal_hemorrhage0.79485013
69MP0000569_abnormal_digit_pigmentation0.77131336
70MP0002876_abnormal_thyroid_physiology0.77103184
71MP0009840_abnormal_foam_cell0.76652289
72MP0002653_abnormal_ependyma_morphology0.76430129
73MP0001905_abnormal_dopamine_level0.75065113
74MP0005166_decreased_susceptibility_to0.74787707
75MP0003329_amyloid_beta_deposits0.74651424
76MP0008057_abnormal_DNA_replication0.74358824
77MP0003567_abnormal_fetal_cardiomyocyte0.72624757
78MP0005167_abnormal_blood-brain_barrier0.71872466
79MP0005085_abnormal_gallbladder_physiolo0.71757956
80MP0009643_abnormal_urine_homeostasis0.70799735
81MP0005253_abnormal_eye_physiology0.70586012
82MP0001663_abnormal_digestive_system0.68719552
83MP0005410_abnormal_fertilization0.66487142
84MP0002277_abnormal_respiratory_mucosa0.66386198
85MP0005084_abnormal_gallbladder_morpholo0.63133517
86MP0003075_altered_response_to0.62903168
87MP0008872_abnormal_physiological_respon0.62599778
88MP0002136_abnormal_kidney_physiology0.62357089
89MP0002909_abnormal_adrenal_gland0.60418495
90MP0005075_abnormal_melanosome_morpholog0.60354853
91MP0001119_abnormal_female_reproductive0.59097939
92MP0001346_abnormal_lacrimal_gland0.58488469
93MP0000372_irregular_coat_pigmentation0.57920826
94MP0005389_reproductive_system_phenotype0.55769587
95MP0003137_abnormal_impulse_conducting0.55624827
96MP0005645_abnormal_hypothalamus_physiol0.54452430
97MP0005390_skeleton_phenotype0.54032187
98MP0005636_abnormal_mineral_homeostasis0.53690101
99MP0003638_abnormal_response/metabolism_0.53605154
100MP0002102_abnormal_ear_morphology0.53473819

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)7.09919425
2T lymphocytopenia (HP:0005403)5.51074948
3Abnormality of T cell number (HP:0011839)5.21180518
4IgG deficiency (HP:0004315)5.18047439
5Elevated erythrocyte sedimentation rate (HP:0003565)4.61304018
6Severe combined immunodeficiency (HP:0004430)4.34437015
7Increased IgM level (HP:0003496)4.32700218
8Stomatitis (HP:0010280)4.22911602
9Hypoproteinemia (HP:0003075)3.96732544
10Combined immunodeficiency (HP:0005387)3.65827569
11Autoimmune hemolytic anemia (HP:0001890)3.59286911
12Abnormality of T cells (HP:0002843)3.48498565
13Chronic mucocutaneous candidiasis (HP:0002728)3.34796365
14Recurrent cutaneous fungal infections (HP:0011370)3.34796365
15Abnormality of eosinophils (HP:0001879)3.34194409
16Thyroiditis (HP:0100646)3.29089566
17Hypoplasia of the thymus (HP:0000778)3.27384240
18Joint swelling (HP:0001386)3.26475524
19Pancytopenia (HP:0001876)3.19582392
20Abnormality of macrophages (HP:0004311)3.18946601
21Chronic diarrhea (HP:0002028)3.07007144
22Encephalitis (HP:0002383)3.02564809
23Rib fusion (HP:0000902)2.99946555
24Abnormality of the prostate (HP:0008775)2.95105858
25Anomalous pulmonary venous return (HP:0010772)2.91672421
26Mediastinal lymphadenopathy (HP:0100721)2.83078456
27Eosinophilia (HP:0001880)2.80236580
28Confusion (HP:0001289)2.76778364
29Meningitis (HP:0001287)2.67569953
30Generalized aminoaciduria (HP:0002909)2.65495438
31Recurrent fungal infections (HP:0002841)2.64608156
32Hypergammaglobulinemia (HP:0010702)2.60575146
33Abnormality of the pulmonary veins (HP:0011718)2.54993736
34Chronic obstructive pulmonary disease (HP:0006510)2.51991389
35Obstructive lung disease (HP:0006536)2.51991389
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.47663713
37Lymphopenia (HP:0001888)2.47363330
38Recurrent bronchitis (HP:0002837)2.46486110
39Hypoalbuminemia (HP:0003073)2.45702279
40Abnormal albumin level (HP:0012116)2.45702279
41Hepatocellular necrosis (HP:0001404)2.44402242
42Mesangial abnormality (HP:0001966)2.39069541
43Leukocytosis (HP:0001974)2.37398136
44Abnormality of cells of the lymphoid lineage (HP:0012140)2.34131166
45Lymphoma (HP:0002665)2.33723133
46Amyotrophic lateral sclerosis (HP:0007354)2.33124173
47Granulocytopenia (HP:0001913)2.32600338
48Increased intramyocellular lipid droplets (HP:0012240)2.30150024
49Renal Fanconi syndrome (HP:0001994)2.29679793
50Hyponatremia (HP:0002902)2.29546360
51Increased hepatocellular lipid droplets (HP:0006565)2.29398603
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.26723997
53Recurrent skin infections (HP:0001581)2.23858215
54Cerebral palsy (HP:0100021)2.22612058
55Hepatic necrosis (HP:0002605)2.21428535
56Mitochondrial inheritance (HP:0001427)2.20975965
57IgM deficiency (HP:0002850)2.17376532
58Neuroendocrine neoplasm (HP:0100634)2.16818718
59Autoimmune thrombocytopenia (HP:0001973)2.16596099
60Recurrent abscess formation (HP:0002722)2.15029054
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13139084
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13139084
63Hypokalemic alkalosis (HP:0001949)2.11453785
64Bronchitis (HP:0012387)2.10114833
65Acute hepatic failure (HP:0006554)2.09793176
66Alkalosis (HP:0001948)2.08336984
67Cutaneous melanoma (HP:0012056)2.07812550
68Abnormality of B cell number (HP:0010975)2.05767064
69Abnormality of T cell physiology (HP:0011840)2.04231731
70Polyuria (HP:0000103)2.03291031
71Hemoptysis (HP:0002105)1.99778924
72Polydipsia (HP:0001959)1.97506938
73Abnormal drinking behavior (HP:0030082)1.97506938
74Recurrent viral infections (HP:0004429)1.94641169
75Amniotic constriction ring (HP:0009775)1.94541144
76Abnormality of placental membranes (HP:0011409)1.94541144
77Skin rash (HP:0000988)1.92650323
78Increased CSF lactate (HP:0002490)1.92440162
79Cellular immunodeficiency (HP:0005374)1.91835183
80Lipid accumulation in hepatocytes (HP:0006561)1.90686940
81Fetal akinesia sequence (HP:0001989)1.90658921
82B lymphocytopenia (HP:0010976)1.90080203
83Type I transferrin isoform profile (HP:0003642)1.89321782
84Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88969829
85Recurrent bacterial skin infections (HP:0005406)1.88348066
86Palpitations (HP:0001962)1.88084549
87Myositis (HP:0100614)1.87193349
88Pulmonary infiltrates (HP:0002113)1.85902848
89Optic neuritis (HP:0100653)1.85286729
90Retrobulbar optic neuritis (HP:0100654)1.85286729
91Gangrene (HP:0100758)1.84297624
92Pustule (HP:0200039)1.83244843
93Agammaglobulinemia (HP:0004432)1.83065813
94Dyschromatopsia (HP:0007641)1.83002555
95Neoplasm of head and neck (HP:0012288)1.82370005
96Esophageal neoplasm (HP:0100751)1.82370005
97Hypokalemia (HP:0002900)1.80954138
98Metabolic alkalosis (HP:0200114)1.79995501
99Increased muscle lipid content (HP:0009058)1.79960501
100Polyneuropathy (HP:0001271)1.77926385

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.18626672
2KDR5.12200047
3TESK23.96577603
4TAOK33.42873581
5ZAK3.05989776
6MUSK2.79673412
7VRK22.46848540
8MAPKAPK32.28501277
9TLK12.26080671
10ITK2.23563728
11FES2.23339170
12TEC2.23179403
13SYK2.11504958
14TESK11.95435778
15MST41.95349595
16BTK1.94697688
17MAP4K11.93315091
18CSK1.88262031
19ZAP701.79922340
20TIE11.74870911
21SCYL21.64446437
22VRK11.56466866
23NUAK11.48749032
24LIMK11.35067169
25ADRBK21.33218230
26LCK1.18997457
27GRK11.14624475
28JAK31.14192909
29TYK21.10825891
30GRK61.10628444
31MAP3K111.09136572
32BCKDK1.04363894
33LYN1.03323903
34STK38L1.01113105
35MAP3K121.00607097
36PRKCQ0.97971539
37RIPK40.96821721
38IKBKE0.94737468
39IKBKB0.93414510
40BUB10.92661837
41DAPK10.90222239
42CSF1R0.87155250
43FGR0.85155757
44HCK0.84153399
45TNK20.75544990
46TRPM70.70658415
47MAP2K60.68109281
48ERBB30.67101120
49NLK0.66244235
50JAK20.65655792
51GRK70.64458186
52MAPKAPK50.63542084
53MATK0.63364569
54MAP3K140.61822628
55JAK10.59845602
56FYN0.59176480
57KIT0.57723252
58BCR0.57540352
59MYLK0.56792975
60MAP2K20.56076256
61BRSK20.53971122
62BLK0.53621716
63PIM10.52726505
64MAPK110.52565310
65IGF1R0.52454794
66TBK10.50976702
67ADRBK10.46227491
68TGFBR20.44960869
69MAPKAPK20.44883834
70CAMKK20.44696297
71INSR0.44527211
72BMPR1B0.44461031
73RPS6KA50.40772830
74MAPK130.40713795
75CCNB10.36897526
76BMPR20.36270662
77FRK0.34488247
78MAP3K50.33593134
79ATR0.32472210
80TYRO30.31280966
81PIK3CA0.29316969
82PRKCA0.28784979
83INSRR0.28536123
84ROCK10.27835767
85GRK50.27296182
86ACVR1B0.25503374
87PAK10.24976564
88MAPK30.24822489
89CSNK2A10.24261044
90PRKACA0.24225888
91PDGFRB0.24084137
92CDK80.23367552
93OBSCN0.22972822
94CAMK2A0.22793246
95CSNK1G30.22671932
96ABL10.22350984
97NTRK10.19800121
98CLK10.18838106
99SRC0.18763315
100PRKCD0.15381311

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.50765368
2Proteasome_Homo sapiens_hsa030504.56427700
3Graft-versus-host disease_Homo sapiens_hsa053323.52702737
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.03277899
5Oxidative phosphorylation_Homo sapiens_hsa001902.84452326
6Autoimmune thyroid disease_Homo sapiens_hsa053202.83410954
7Hematopoietic cell lineage_Homo sapiens_hsa046402.74826143
8Antigen processing and presentation_Homo sapiens_hsa046122.67266232
9Allograft rejection_Homo sapiens_hsa053302.60137625
10T cell receptor signaling pathway_Homo sapiens_hsa046602.58366317
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.31235951
12Parkinsons disease_Homo sapiens_hsa050122.13626391
13Type I diabetes mellitus_Homo sapiens_hsa049401.99145843
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96618867
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87729050
16Measles_Homo sapiens_hsa051621.79182239
17Rheumatoid arthritis_Homo sapiens_hsa053231.72919463
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.69953996
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.61791504
20Protein export_Homo sapiens_hsa030601.60652917
21Arginine biosynthesis_Homo sapiens_hsa002201.58056499
22Shigellosis_Homo sapiens_hsa051311.56214262
23Malaria_Homo sapiens_hsa051441.55185441
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42712870
25Alzheimers disease_Homo sapiens_hsa050101.32411735
26Nitrogen metabolism_Homo sapiens_hsa009101.28947119
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26419487
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23846642
29Huntingtons disease_Homo sapiens_hsa050161.23753655
30RNA polymerase_Homo sapiens_hsa030201.16792906
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16451307
32Asthma_Homo sapiens_hsa053101.13676209
33Salmonella infection_Homo sapiens_hsa051321.13622284
34Viral myocarditis_Homo sapiens_hsa054161.12391641
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11041557
36Sulfur metabolism_Homo sapiens_hsa009201.05288942
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03107989
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99963217
39Linoleic acid metabolism_Homo sapiens_hsa005910.99188759
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98983438
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98585223
42Cardiac muscle contraction_Homo sapiens_hsa042600.95592462
43Propanoate metabolism_Homo sapiens_hsa006400.88212647
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82978506
45NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82967916
46Herpes simplex infection_Homo sapiens_hsa051680.81600815
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78969087
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78807434
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74084244
50Selenocompound metabolism_Homo sapiens_hsa004500.72137019
51Osteoclast differentiation_Homo sapiens_hsa043800.68194733
52Fanconi anemia pathway_Homo sapiens_hsa034600.67074368
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66751765
54Homologous recombination_Homo sapiens_hsa034400.66598524
55Phototransduction_Homo sapiens_hsa047440.65868661
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65743029
57Leishmaniasis_Homo sapiens_hsa051400.63909933
58Staphylococcus aureus infection_Homo sapiens_hsa051500.62746369
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62665187
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.62100622
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60163035
62Systemic lupus erythematosus_Homo sapiens_hsa053220.56418682
63DNA replication_Homo sapiens_hsa030300.55946382
64Pyrimidine metabolism_Homo sapiens_hsa002400.54500751
65Butanoate metabolism_Homo sapiens_hsa006500.53420866
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53102312
67HTLV-I infection_Homo sapiens_hsa051660.52257124
68Collecting duct acid secretion_Homo sapiens_hsa049660.50885652
69Chemokine signaling pathway_Homo sapiens_hsa040620.49785835
70Apoptosis_Homo sapiens_hsa042100.48731889
71Basal transcription factors_Homo sapiens_hsa030220.47209530
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47148654
73N-Glycan biosynthesis_Homo sapiens_hsa005100.41981469
74Ribosome_Homo sapiens_hsa030100.41619505
75Epstein-Barr virus infection_Homo sapiens_hsa051690.39038530
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37932081
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37499580
78Regulation of autophagy_Homo sapiens_hsa041400.35542540
79Chemical carcinogenesis_Homo sapiens_hsa052040.34883205
80Purine metabolism_Homo sapiens_hsa002300.34013403
81Non-homologous end-joining_Homo sapiens_hsa034500.33133829
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32561238
83Legionellosis_Homo sapiens_hsa051340.32470006
84Phagosome_Homo sapiens_hsa041450.29090300
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28064217
86Pertussis_Homo sapiens_hsa051330.27748130
87RNA degradation_Homo sapiens_hsa030180.27547054
88Lysosome_Homo sapiens_hsa041420.27235182
89Ether lipid metabolism_Homo sapiens_hsa005650.25411809
90Taste transduction_Homo sapiens_hsa047420.25299638
91One carbon pool by folate_Homo sapiens_hsa006700.25245997
92Nucleotide excision repair_Homo sapiens_hsa034200.25200632
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.20340966
94Metabolic pathways_Homo sapiens_hsa011000.20095020
95Fat digestion and absorption_Homo sapiens_hsa049750.20090153
96Arachidonic acid metabolism_Homo sapiens_hsa005900.18536883
97Peroxisome_Homo sapiens_hsa041460.18180373
98B cell receptor signaling pathway_Homo sapiens_hsa046620.16364761
99Mismatch repair_Homo sapiens_hsa034300.16162926
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.15882081

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