OSTM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)6.99831684
2melanin metabolic process (GO:0006582)6.29258030
3secondary metabolite biosynthetic process (GO:0044550)5.68280831
4negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.47125211
5developmental pigmentation (GO:0048066)4.14996787
6nodal signaling pathway (GO:0038092)3.80758058
7pigment cell differentiation (GO:0050931)3.55784495
8L-amino acid import (GO:0043092)3.50722948
9neutrophil activation involved in immune response (GO:0002283)3.44140088
10positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.43486293
11blood vessel maturation (GO:0001955)3.41962653
12adenosine receptor signaling pathway (GO:0001973)3.41576572
13keratan sulfate catabolic process (GO:0042340)3.40058443
14negative regulation of cell killing (GO:0031342)3.34548308
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.34548308
16cellular response to thyroid hormone stimulus (GO:0097067)3.31424245
17presynaptic membrane assembly (GO:0097105)3.28815401
18neuromuscular process controlling posture (GO:0050884)3.27970871
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.26174545
20melanocyte differentiation (GO:0030318)3.19855618
21regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.19168247
22regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.12827582
23melanosome organization (GO:0032438)3.11472943
24presynaptic membrane organization (GO:0097090)3.10939493
25positive regulation of protein autophosphorylation (GO:0031954)3.00031212
26detection of molecule of bacterial origin (GO:0032490)2.98098775
27oligosaccharide catabolic process (GO:0009313)2.97168813
28positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.95673124
29positive regulation of tolerance induction (GO:0002645)2.94870897
30signal peptide processing (GO:0006465)2.93100048
31pigment granule organization (GO:0048753)2.90630893
32amino acid import (GO:0043090)2.90307909
33negative regulation of neurotransmitter transport (GO:0051589)2.88386946
34activated T cell proliferation (GO:0050798)2.85735669
35negative regulation of lipid storage (GO:0010888)2.85541509
36neuronal action potential propagation (GO:0019227)2.83640417
37negative regulation of interleukin-1 production (GO:0032692)2.80721248
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80678434
39negative regulation of cation channel activity (GO:2001258)2.80663950
40regulation of neuron projection regeneration (GO:0070570)2.79443639
41regulation of axon regeneration (GO:0048679)2.79443639
42phagosome maturation (GO:0090382)2.79342209
43positive regulation of receptor recycling (GO:0001921)2.76893454
44positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.74791340
45cellular extravasation (GO:0045123)2.74711386
46granulocyte activation (GO:0036230)2.74262147
47endosome to melanosome transport (GO:0035646)2.73489644
48endosome to pigment granule transport (GO:0043485)2.73489644
49negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.73336419
50response to peptidoglycan (GO:0032494)2.71213874
51negative regulation of interleukin-1 beta production (GO:0032691)2.71114462
52synaptic vesicle exocytosis (GO:0016079)2.70034827
53regulation of tolerance induction (GO:0002643)2.69753789
54regulation of integrin-mediated signaling pathway (GO:2001044)2.68493715
55long-chain fatty acid biosynthetic process (GO:0042759)2.67604981
56neuron cell-cell adhesion (GO:0007158)2.67164268
57regulation of interferon-beta biosynthetic process (GO:0045357)2.66286049
58protein targeting to vacuole (GO:0006623)2.65819822
59protein targeting to lysosome (GO:0006622)2.65819822
60establishment of protein localization to vacuole (GO:0072666)2.65819822
61regulation of short-term neuronal synaptic plasticity (GO:0048172)2.65179819
62central nervous system myelination (GO:0022010)2.65122963
63axon ensheathment in central nervous system (GO:0032291)2.65122963
64tyrosine phosphorylation of STAT protein (GO:0007260)2.64476998
65interleukin-1-mediated signaling pathway (GO:0070498)2.64255356
66glutamate secretion (GO:0014047)2.63922828
67positive regulation of monocyte chemotaxis (GO:0090026)2.62013249
68regulation of glutamate secretion (GO:0014048)2.61949190
69substrate-dependent cell migration (GO:0006929)2.61875637
70lytic vacuole organization (GO:0080171)2.60888820
71lysosome organization (GO:0007040)2.60888820
72transferrin transport (GO:0033572)2.59988248
73phenol-containing compound biosynthetic process (GO:0046189)2.58884702
74glucosamine-containing compound catabolic process (GO:1901072)2.56436635
75response to histamine (GO:0034776)2.56196942
76neutrophil activation (GO:0042119)2.55861029
77parental behavior (GO:0060746)2.55726011
78macrophage activation involved in immune response (GO:0002281)2.55546142
79metanephric mesenchyme development (GO:0072075)2.54025283
80platelet dense granule organization (GO:0060155)2.53808788
81metanephric tubule development (GO:0072170)2.52836222
82metanephric nephron tubule development (GO:0072234)2.52836222
83negative regulation of bone resorption (GO:0045779)2.52470173
84modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.52309472
85modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.52309472
86positive regulation by organism of defense response of other organism involved in symbiotic interact2.52309472
87modulation by symbiont of host immune response (GO:0052553)2.52309472
88positive regulation by symbiont of host defense response (GO:0052509)2.52309472
89modulation by symbiont of host defense response (GO:0052031)2.52309472
90phagocytosis, recognition (GO:0006910)2.51955674
91regulation of synaptic vesicle exocytosis (GO:2000300)2.50106646
92negative regulation of calcium ion transmembrane transport (GO:1903170)2.49179428
93negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.49179428
94protein localization to endosome (GO:0036010)2.48140300
95neuron remodeling (GO:0016322)2.48006962
96positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.47706937
97Rap protein signal transduction (GO:0032486)2.47706490
98negative regulation of interleukin-17 production (GO:0032700)2.46010526
99negative regulation of synaptic transmission, GABAergic (GO:0032229)2.45965019
100proline transport (GO:0015824)2.45304091
101positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.44728852
102regulation of mononuclear cell migration (GO:0071675)2.44324720
103antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.43733857
104actin nucleation (GO:0045010)2.43087043
105tyrosine metabolic process (GO:0006570)2.42615893
106glycosphingolipid catabolic process (GO:0046479)2.42530374
107regulation of vesicle fusion (GO:0031338)2.41475621
108negative regulation of mast cell activation (GO:0033004)2.41377003
109regulation of beta-amyloid formation (GO:1902003)2.41171301
110negative regulation of protein autophosphorylation (GO:0031953)2.40441697
111ferric iron transport (GO:0015682)2.40429097
112trivalent inorganic cation transport (GO:0072512)2.40429097
113positive regulation of T cell chemotaxis (GO:0010820)2.40317933
114regulation of T cell chemotaxis (GO:0010819)2.40317933
115positive regulation of mast cell activation (GO:0033005)2.39895253
116cell adhesion mediated by integrin (GO:0033627)2.39568902
117neutrophil mediated immunity (GO:0002446)2.38787034
118intracellular pH reduction (GO:0051452)2.38569413
119positive regulation of synaptic transmission, GABAergic (GO:0032230)2.37711675
120negative regulation of protein localization to plasma membrane (GO:1903077)2.37623437
121negative regulation of interleukin-12 production (GO:0032695)2.36289241
122synaptic transmission, glutamatergic (GO:0035249)2.36226418
123positive regulation of neurotransmitter secretion (GO:0001956)2.36027408
124regulation of membrane protein ectodomain proteolysis (GO:0051043)2.36002093
125metanephric nephron epithelium development (GO:0072243)2.35880770
126ionotropic glutamate receptor signaling pathway (GO:0035235)2.35760205
127negative regulation of phagocytosis (GO:0050765)2.34920184
128regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.34844831
129regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.33479328
130response to thyroid hormone (GO:0097066)2.32839711
131microglial cell activation (GO:0001774)2.32562515
132antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.32282772
133regulation of protein autophosphorylation (GO:0031952)2.32091236
134amino sugar catabolic process (GO:0046348)2.30808019
135ketone body metabolic process (GO:1902224)2.30777728
136daunorubicin metabolic process (GO:0044597)2.30485358
137polyketide metabolic process (GO:0030638)2.30485358
138doxorubicin metabolic process (GO:0044598)2.30485358
139L-serine transport (GO:0015825)2.30101797
140regulation of mast cell activation (GO:0033003)2.29824480
141regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.29690996
142glycosylceramide metabolic process (GO:0006677)2.28932219
143pH reduction (GO:0045851)2.28720911
144negative regulation of nitric oxide biosynthetic process (GO:0045019)2.28637412
145respiratory burst (GO:0045730)2.28581045
146eosinophil chemotaxis (GO:0048245)2.28279497
147regulation of amyloid precursor protein catabolic process (GO:1902991)2.27449847
148positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.26982426
149nerve growth factor signaling pathway (GO:0038180)2.26378955
150negative regulation of neurotransmitter secretion (GO:0046929)2.25564290
151positive regulation of gamma-delta T cell activation (GO:0046645)2.25437076
152regulation of excitatory postsynaptic membrane potential (GO:0060079)2.24764490
153cellular response to fluid shear stress (GO:0071498)2.24643333
154dopamine biosynthetic process (GO:0042416)2.24462867
155myeloid cell activation involved in immune response (GO:0002275)2.24001803
156neuron-neuron synaptic transmission (GO:0007270)2.23761571
157G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.23265967
158regulation of lymphocyte chemotaxis (GO:1901623)2.22197856
159regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.22121509
160regulation of platelet aggregation (GO:0090330)2.21584194
161positive regulation of cellular amide metabolic process (GO:0034250)2.21527751
162regulation of macrophage cytokine production (GO:0010935)2.20853977
163leukocyte migration involved in inflammatory response (GO:0002523)2.20689584
164sphingosine metabolic process (GO:0006670)2.20358508
165negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.19476358
166kidney mesenchyme development (GO:0072074)2.19220241
167clathrin coat assembly (GO:0048268)2.19147313
168regulation of interleukin-1 beta production (GO:0032651)2.18887737
169ER overload response (GO:0006983)2.18616588
170positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.18588898
171mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.18588898
172negative regulation of T cell receptor signaling pathway (GO:0050860)2.18540749
173locomotory exploration behavior (GO:0035641)2.18390469
174regulation of interleukin-1 production (GO:0032652)2.18377756
175cellular response to ethanol (GO:0071361)2.18181017
176regulation of chemokine biosynthetic process (GO:0045073)2.17839139
177N-acetylneuraminate metabolic process (GO:0006054)2.17746185
178positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.17683229
179maternal behavior (GO:0042711)2.17482990
180dendritic cell migration (GO:0036336)2.17464060
181regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.17372856

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.51919458
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.61307735
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55985278
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.54598565
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.33000001
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.23284366
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15757049
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.08629751
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05441171
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.02831197
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.01178798
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97746787
13RUNX_20019798_ChIP-Seq_JUKART_Human1.95104076
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92171283
15AR_21572438_ChIP-Seq_LNCaP_Human1.88886813
16IRF8_27001747_Chip-Seq_BMDM_Mouse1.87226343
17* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.83468650
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81682555
19EZH2_22144423_ChIP-Seq_EOC_Human1.81640886
20* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81401498
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76414582
22MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75955908
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75810100
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75525167
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75246739
26TAF15_26573619_Chip-Seq_HEK293_Human1.74692665
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.74173407
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73956988
29DROSHA_22980978_ChIP-Seq_HELA_Human1.73385899
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73173441
31IGF1R_20145208_ChIP-Seq_DFB_Human1.68880072
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68659911
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60021090
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59986665
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59986665
36* EZH2_27294783_Chip-Seq_NPCs_Mouse1.57087531
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55473616
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55045970
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.54077374
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52903430
41ER_23166858_ChIP-Seq_MCF-7_Human1.49671091
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46769806
43* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.46758917
44P300_19829295_ChIP-Seq_ESCs_Human1.46672479
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44393026
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42599171
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.42481755
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42013893
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38625733
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37853031
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37008746
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36726855
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35745201
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35745201
55TP53_18474530_ChIP-ChIP_U2OS_Human1.34563633
56TFEB_21752829_ChIP-Seq_HELA_Human1.33708986
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32555864
58BRD4_25478319_ChIP-Seq_HGPS_Human1.31806650
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31579000
60TP53_16413492_ChIP-PET_HCT116_Human1.31335245
61REST_21632747_ChIP-Seq_MESCs_Mouse1.30886052
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.30658095
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28661365
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28365409
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28245727
66RARB_27405468_Chip-Seq_BRAIN_Mouse1.26450424
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26295053
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25483209
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25441402
70* CRX_20693478_ChIP-Seq_RETINA_Mouse1.24711750
71TP63_23658742_ChIP-Seq_EP156T_Human1.24381261
72* PU_27001747_Chip-Seq_BMDM_Mouse1.24231839
73* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23978244
74SCL_19346495_ChIP-Seq_HPC-7_Human1.23644460
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.22755572
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22650634
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21872699
78* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.20701370
79JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20405659
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.19961063
81SMAD4_21799915_ChIP-Seq_A2780_Human1.19743927
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19090883
83P53_22387025_ChIP-Seq_ESCs_Mouse1.18650049
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17700068
85* RNF2_27304074_Chip-Seq_ESCs_Mouse1.17626875
86JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17323126
87AR_25329375_ChIP-Seq_VCAP_Human1.16255822
88GATA3_26560356_Chip-Seq_TH2_Human1.16226063
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15806034
90* CDX2_22108803_ChIP-Seq_LS180_Human1.14274414
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13370535
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13133777
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12939267
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11647652
95GATA1_22025678_ChIP-Seq_K562_Human1.11484774
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.09769976
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09695583
98BCAT_22108803_ChIP-Seq_LS180_Human1.09419400
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09329219
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08465851
101FUS_26573619_Chip-Seq_HEK293_Human1.08307975
102GATA2_21666600_ChIP-Seq_HMVEC_Human1.08087739
103ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07127682
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07016890
105RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06564307
106IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05865837
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05853837
108EZH2_27304074_Chip-Seq_ESCs_Mouse1.05799532
109TAL1_26923725_Chip-Seq_HPCs_Mouse1.05553075
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05474430
111REST_18959480_ChIP-ChIP_MESCs_Mouse1.05198501
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.04940368
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04406946
114JUN_21703547_ChIP-Seq_K562_Human1.04344756
115VDR_24787735_ChIP-Seq_THP-1_Human1.03944105
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03306019
117SPI1_23127762_ChIP-Seq_K562_Human1.03042595
118STAT3_18555785_Chip-Seq_ESCs_Mouse1.02767985
119RXR_22108803_ChIP-Seq_LS180_Human0.99202926
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98489144
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98482878
122* STAT3_23295773_ChIP-Seq_U87_Human0.97749763
123PU1_27457419_Chip-Seq_LIVER_Mouse0.97252313
124PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97163784
125P300_18555785_Chip-Seq_ESCs_Mouse0.97054919
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96629146
127LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96355290
128KDM2B_26808549_Chip-Seq_REH_Human0.95713741
129FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95016214
130EED_16625203_ChIP-ChIP_MESCs_Mouse0.94734134
131STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94452441
132TCF4_23295773_ChIP-Seq_U87_Human0.93746531
133FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93612192
134RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93138733
135RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92784257
136SOX2_21211035_ChIP-Seq_LN229_Gbm0.89306334
137MYB_26560356_Chip-Seq_TH2_Human0.87375628
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87031737
139* FLI1_21867929_ChIP-Seq_TH2_Mouse0.85801371
140CMYC_18555785_Chip-Seq_ESCs_Mouse0.85636207
141WT1_19549856_ChIP-ChIP_CCG9911_Human0.85602572
142CJUN_26792858_Chip-Seq_BT549_Human0.85494139
143SMAD3_21741376_ChIP-Seq_EPCs_Human0.84680698
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84042027
145E2F1_18555785_Chip-Seq_ESCs_Mouse0.83699509

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ4.49724070
2MP0004510_myositis3.97166120
3MP0005058_abnormal_lysosome_morphology3.65373427
4MP0005408_hypopigmentation3.39259993
5MP0000569_abnormal_digit_pigmentation3.27417822
6MP0006082_CNS_inflammation3.12204655
7MP0004859_abnormal_synaptic_plasticity3.08471418
8MP0003880_abnormal_central_pattern2.74986324
9MP0000371_diluted_coat_color2.72465284
10MP0003136_yellow_coat_color2.67415082
11MP0005075_abnormal_melanosome_morpholog2.67157459
12MP0002095_abnormal_skin_pigmentation2.31643000
13MP0004270_analgesia2.29734430
14MP0003172_abnormal_lysosome_physiology2.23192489
15MP0006054_spinal_hemorrhage2.23136553
16MP0009046_muscle_twitch2.22193420
17MP0002254_reproductive_system_inflammat2.21859927
18MP0002064_seizures2.20358796
19MP0004381_abnormal_hair_follicle2.17280345
20MP0003635_abnormal_synaptic_transmissio2.13263467
21MP0000920_abnormal_myelination2.12498163
22MP0005423_abnormal_somatic_nervous1.99071908
23MP0009745_abnormal_behavioral_response1.93000743
24MP0000343_altered_response_to1.88700508
25MP0002272_abnormal_nervous_system1.88475250
26MP0003690_abnormal_glial_cell1.88134199
27MP0001873_stomach_inflammation1.87991692
28MP0005671_abnormal_response_to1.86596538
29MP0005257_abnormal_intraocular_pressure1.83201650
30MP0002572_abnormal_emotion/affect_behav1.80795569
31MP0004885_abnormal_endolymph1.80014504
32MP0001968_abnormal_touch/_nociception1.76689329
33MP0003075_altered_response_to1.75924087
34MP0003828_pulmonary_edema1.68583457
35MP0004133_heterotaxia1.68252196
36MP0002419_abnormal_innate_immunity1.66451717
37MP0001324_abnormal_eye_pigmentation1.65892949
38MP0002063_abnormal_learning/memory/cond1.62673733
39MP0001905_abnormal_dopamine_level1.62047928
40MP0002736_abnormal_nociception_after1.61593490
41MP0002735_abnormal_chemical_nociception1.61540918
42MP0001835_abnormal_antigen_presentation1.60586925
43MP0005409_darkened_coat_color1.58356045
44MP0009764_decreased_sensitivity_to1.50912195
45MP0001986_abnormal_taste_sensitivity1.50827068
46MP0009780_abnormal_chondrocyte_physiolo1.48251315
47MP0003329_amyloid_beta_deposits1.48184659
48MP0005000_abnormal_immune_tolerance1.48182599
49* MP0002998_abnormal_bone_remodeling1.46682847
50MP0003183_abnormal_peptide_metabolism1.45667131
51MP0003300_gastrointestinal_ulcer1.45092454
52MP0003806_abnormal_nucleotide_metabolis1.43582889
53MP0005171_absent_coat_pigmentation1.40795011
54MP0002733_abnormal_thermal_nociception1.39952334
55MP0000604_amyloidosis1.39941744
56MP0002933_joint_inflammation1.38697590
57MP0003279_aneurysm1.34027476
58MP0002148_abnormal_hypersensitivity_rea1.33940782
59MP0010386_abnormal_urinary_bladder1.31513827
60MP0001970_abnormal_pain_threshold1.31207541
61MP0009840_abnormal_foam_cell1.30986725
62MP0000372_irregular_coat_pigmentation1.30279181
63MP0002102_abnormal_ear_morphology1.29745780
64MP0003303_peritoneal_inflammation1.29178248
65MP0001486_abnormal_startle_reflex1.28857357
66MP0003724_increased_susceptibility_to1.28781555
67MP0001501_abnormal_sleep_pattern1.28234906
68MP0004742_abnormal_vestibular_system1.27519844
69MP0002723_abnormal_immune_serum1.25336922
70* MP0002075_abnormal_coat/hair_pigmentati1.23814340
71MP0002067_abnormal_sensory_capabilities1.21140715
72MP0001440_abnormal_grooming_behavior1.21050870
73MP0001819_abnormal_immune_cell1.20945792
74MP0002452_abnormal_antigen_presenting1.19938131
75MP0002420_abnormal_adaptive_immunity1.19807056
76* MP0001186_pigmentation_phenotype1.19348095
77MP0005464_abnormal_platelet_physiology1.19336204
78MP0002734_abnormal_mechanical_nocicepti1.18262234
79MP0002184_abnormal_innervation1.17177018
80MP0003634_abnormal_glial_cell1.16415973
81MP0001533_abnormal_skeleton_physiology1.16301535
82MP0008569_lethality_at_weaning1.16252588
83MP0009785_altered_susceptibility_to1.14793524
84MP0004858_abnormal_nervous_system1.14680303
85MP0001529_abnormal_vocalization1.14363909
86MP0003633_abnormal_nervous_system1.13789174
87MP0002557_abnormal_social/conspecific_i1.13033172
88MP0001790_abnormal_immune_system1.11757440
89MP0005387_immune_system_phenotype1.11757440
90MP0010368_abnormal_lymphatic_system1.09879418
91MP0005379_endocrine/exocrine_gland_phen1.09677762
92MP0001542_abnormal_bone_strength1.08747835
93MP0005164_abnormal_response_to1.08072078
94MP0002166_altered_tumor_susceptibility1.05995419
95MP0000465_gastrointestinal_hemorrhage1.04313976
96MP0005166_decreased_susceptibility_to0.99940917
97MP0003950_abnormal_plasma_membrane0.98720795
98MP0003656_abnormal_erythrocyte_physiolo0.97846182
99MP0003195_calcinosis0.97764738
100MP0005197_abnormal_uvea_morphology0.97743330
101MP0002006_tumorigenesis0.97456161
102MP0001845_abnormal_inflammatory_respons0.96901724
103MP0001958_emphysema0.96637446
104MP0005025_abnormal_response_to0.96224497
105MP0004883_abnormal_blood_vessel0.94511816
106MP0004484_altered_response_of0.93223609
107MP0002090_abnormal_vision0.92830093
108MP0008438_abnormal_cutaneous_collagen0.92747088
109* MP0001851_eye_inflammation0.91796756
110MP0001800_abnormal_humoral_immune0.91217706
111MP0003448_altered_tumor_morphology0.90161066
112MP0003631_nervous_system_phenotype0.89906607
113MP0008260_abnormal_autophagy0.89857427
114MP0002405_respiratory_system_inflammati0.89684581
115MP0005310_abnormal_salivary_gland0.89388809
116MP0002837_dystrophic_cardiac_calcinosis0.89168222
117MP0001853_heart_inflammation0.87231566
118MP0002229_neurodegeneration0.85549878
119MP0001879_abnormal_lymphatic_vessel0.85174069
120MP0005253_abnormal_eye_physiology0.84726143
121MP0001502_abnormal_circadian_rhythm0.84093364
122MP0005167_abnormal_blood-brain_barrier0.84063960
123MP0000685_abnormal_immune_system0.83274053
124MP0003186_abnormal_redox_activity0.83072803
125MP0010234_abnormal_vibrissa_follicle0.83029217
126MP0003436_decreased_susceptibility_to0.82793958
127MP0003191_abnormal_cellular_cholesterol0.82138749
128MP0002877_abnormal_melanocyte_morpholog0.82016066
129MP0005451_abnormal_body_composition0.81413804
130MP0004924_abnormal_behavior0.80821473
131MP0005386_behavior/neurological_phenoty0.80821473
132MP0006276_abnormal_autonomic_nervous0.80490541
133MP0004142_abnormal_muscle_tone0.79060801
134MP0005595_abnormal_vascular_smooth0.78822282
135MP0002163_abnormal_gland_morphology0.78368196
136MP0004947_skin_inflammation0.77457363
137MP0000716_abnormal_immune_system0.77025763
138MP0002295_abnormal_pulmonary_circulatio0.76987914
139MP0000015_abnormal_ear_pigmentation0.76969237
140* MP0002066_abnormal_motor_capabilities/c0.75094268
141MP0005174_abnormal_tail_pigmentation0.74995066
142MP0005084_abnormal_gallbladder_morpholo0.74966842
143MP0003011_delayed_dark_adaptation0.74498951
144MP0008469_abnormal_protein_level0.72976273
145MP0002909_abnormal_adrenal_gland0.71142377
146MP0005275_abnormal_skin_tensile0.69587293
147MP0000767_abnormal_smooth_muscle0.64036722
148MP0005248_abnormal_Harderian_gland0.62862920
149MP0005390_skeleton_phenotype0.61966244
150MP0005165_increased_susceptibility_to0.61910258
151MP0004272_abnormal_basement_membrane0.59791334
152* MP0003795_abnormal_bone_structure0.56513001

Predicted human phenotypes

RankGene SetZ-score
1Entropion (HP:0000621)4.79031548
2Increased cerebral lipofuscin (HP:0011813)4.64212475
3Aplasia/Hypoplasia of the fovea (HP:0008060)4.51652020
4Hypoplasia of the fovea (HP:0007750)4.51652020
5Increased neuronal autofluorescent lipopigment (HP:0002074)4.50533592
6Aplasia/Hypoplasia of the macula (HP:0008059)4.49928153
7Double outlet right ventricle (HP:0001719)4.44856410
8Congenital malformation of the right heart (HP:0011723)4.44856410
9Dysostosis multiplex (HP:0000943)4.43704315
10Ocular albinism (HP:0001107)4.40330940
11Vacuolated lymphocytes (HP:0001922)4.17824654
12Aplasia/Hypoplasia affecting the retina (HP:0008061)4.11443496
13Abnormality of the fovea (HP:0000493)4.10980570
14Urinary glycosaminoglycan excretion (HP:0003541)3.99904187
15Mucopolysacchariduria (HP:0008155)3.99904187
16Iris hypopigmentation (HP:0007730)3.82535647
17Abnormality of mucopolysaccharide metabolism (HP:0011020)3.76768030
18Abnormality of polysaccharide metabolism (HP:0011012)3.76768030
19Abnormality of glycosaminoglycan metabolism (HP:0004371)3.76768030
20Blue irides (HP:0000635)3.65344391
21Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.55628664
22Degeneration of the lateral corticospinal tracts (HP:0002314)3.50849547
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.50849547
24Focal motor seizures (HP:0011153)3.48236395
25Albinism (HP:0001022)3.43546441
26Abnormality of the periventricular white matter (HP:0002518)3.41233333
27Hematochezia (HP:0002573)3.32296067
28White forelock (HP:0002211)3.32025693
29Poikiloderma (HP:0001029)3.27813414
30Abnormality of glycolipid metabolism (HP:0010969)3.27346897
31Abnormality of liposaccharide metabolism (HP:0010968)3.27346897
32Abnormality of glycosphingolipid metabolism (HP:0004343)3.27346897
33Patchy hypopigmentation of hair (HP:0011365)3.26339849
34Generalized hypopigmentation (HP:0007513)3.23991790
35Supranuclear gaze palsy (HP:0000605)3.19825915
36Recurrent abscess formation (HP:0002722)3.15577775
37Myocardial infarction (HP:0001658)3.09875042
38Abnormality of macrophages (HP:0004311)3.05462277
39Atonic seizures (HP:0010819)3.01059765
40Abnormality of the corticospinal tract (HP:0002492)2.94696810
41Hypothermia (HP:0002045)2.94383443
42Neurofibrillary tangles (HP:0002185)2.92456229
43Striae distensae (HP:0001065)2.91156674
44Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.80584368
45Choroideremia (HP:0001139)2.79524973
46Abnormality of binocular vision (HP:0011514)2.77854769
47Diplopia (HP:0000651)2.77854769
48Progressive inability to walk (HP:0002505)2.73496657
49Progressive neurologic deterioration (HP:0002344)2.69465799
50Congenital sensorineural hearing impairment (HP:0008527)2.69028716
51Febrile seizures (HP:0002373)2.66800968
52Akinesia (HP:0002304)2.64683670
53Eczematoid dermatitis (HP:0000976)2.64340641
54Disinhibition (HP:0000734)2.62212837
55Abnormality of the vasculature of the conjunctiva (HP:0008054)2.61001658
56Abdominal situs inversus (HP:0003363)2.58719931
57Abnormality of abdominal situs (HP:0011620)2.58719931
58Epileptic encephalopathy (HP:0200134)2.57376683
59Heterochromia iridis (HP:0001100)2.55683246
60Recurrent bacterial skin infections (HP:0005406)2.50966146
61Constricted visual fields (HP:0001133)2.50769163
62Slow saccadic eye movements (HP:0000514)2.48533142
63Clumsiness (HP:0002312)2.48336240
64Pheochromocytoma (HP:0002666)2.44036813
65Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.42249025
66Focal seizures (HP:0007359)2.40519080
67Retrobulbar optic neuritis (HP:0100654)2.38035410
68Optic neuritis (HP:0100653)2.38035410
69Mutism (HP:0002300)2.37154591
70Cerebral hemorrhage (HP:0001342)2.34849202
71Generalized hypopigmentation of hair (HP:0011358)2.33716763
72Ectropion (HP:0000656)2.33633592
73Asymmetric septal hypertrophy (HP:0001670)2.30467210
74Cutaneous melanoma (HP:0012056)2.29844864
75Neuroendocrine neoplasm (HP:0100634)2.29686541
76Sensory axonal neuropathy (HP:0003390)2.29171202
77Orchitis (HP:0100796)2.28904153
78Conjunctival telangiectasia (HP:0000524)2.28444609
79Papilledema (HP:0001085)2.28114115
80Tetraparesis (HP:0002273)2.27147887
81Peritonitis (HP:0002586)2.21429955
82Cerebral inclusion bodies (HP:0100314)2.21321100
83Generalized tonic-clonic seizures (HP:0002069)2.17591438
84Frequent falls (HP:0002359)2.15932023
85Global brain atrophy (HP:0002283)2.08760832
86Epidermoid cyst (HP:0200040)2.07104409
87Purpura (HP:0000979)2.06611986
88Abnormal hair whorl (HP:0010721)2.05651043
89Stomatitis (HP:0010280)2.04419825
90Hepatosplenomegaly (HP:0001433)2.04122053
91Freckling (HP:0001480)2.03982581
92Congenital stationary night blindness (HP:0007642)2.03678118
93Truncal ataxia (HP:0002078)2.01236471
94Basal ganglia calcification (HP:0002135)1.99671523
95Myositis (HP:0100614)1.99510669
96Hemiplegia (HP:0002301)1.99246162
97Bilateral sensorineural hearing impairment (HP:0008619)1.97727558
98Thick nail (HP:0001805)1.96778347
99Hyperventilation (HP:0002883)1.96567186
100Hypokinesia (HP:0002375)1.96180814
101Recurrent gram-negative bacterial infections (HP:0005420)1.95988006
102Pulmonary infiltrates (HP:0002113)1.95752623
103Limb hypertonia (HP:0002509)1.93843420
104Absence seizures (HP:0002121)1.93298758
105Spontaneous hematomas (HP:0007420)1.92903787
106Diminished movement (HP:0002374)1.91287273
107Progressive visual loss (HP:0000529)1.91192134
108Loss of speech (HP:0002371)1.90903070
109Gastrointestinal infarctions (HP:0005244)1.90855038
110Dialeptic seizures (HP:0011146)1.90363160
111Absent frontal sinuses (HP:0002688)1.90251980
112Visual hallucinations (HP:0002367)1.89970041
113Recurrent skin infections (HP:0001581)1.89004973
114Vascular tortuosity (HP:0004948)1.86610772
115Gingival bleeding (HP:0000225)1.85191190
116Lower limb muscle weakness (HP:0007340)1.84744451
117Progressive cerebellar ataxia (HP:0002073)1.84708878
118Tongue fasciculations (HP:0001308)1.84510247
119Arterial thrombosis (HP:0004420)1.82145251
120Follicular hyperkeratosis (HP:0007502)1.81933317
121Ovoid vertebral bodies (HP:0003300)1.81481649
122Spastic gait (HP:0002064)1.81029638
123Ketoacidosis (HP:0001993)1.80691529
124Muscle fibrillation (HP:0010546)1.80126538
125Osteolytic defects of the phalanges of the hand (HP:0009771)1.79467740
126Osteolytic defects of the hand bones (HP:0009699)1.79467740
127Hypopigmentation of the fundus (HP:0007894)1.78956409
128Mediastinal lymphadenopathy (HP:0100721)1.78194099
129Hypoplasia of the iris (HP:0007676)1.77303142
130Corneal dystrophy (HP:0001131)1.75357696
131Vertebral compression fractures (HP:0002953)1.72669641
132Arterial tortuosity (HP:0005116)1.72348957
133Papillary thyroid carcinoma (HP:0002895)1.72187981
134Abnormality of DNA repair (HP:0003254)1.71534619
135Chronic obstructive pulmonary disease (HP:0006510)1.71360227
136Obstructive lung disease (HP:0006536)1.71360227
137Widely spaced teeth (HP:0000687)1.70849793
138True hermaphroditism (HP:0010459)1.69729816
139Petechiae (HP:0000967)1.69462989
140Keratitis (HP:0000491)1.69179151
141Inability to walk (HP:0002540)1.69132897
142Skin nodule (HP:0200036)1.69044659
143Prolonged bleeding time (HP:0003010)1.68701075
144Oligodontia (HP:0000677)1.68234477
145Dysmetria (HP:0001310)1.67724119
146Nonprogressive disorder (HP:0003680)1.66588542
147Chronic mucocutaneous candidiasis (HP:0002728)1.65354341
148Recurrent cutaneous fungal infections (HP:0011370)1.65354341
149Spondylolisthesis (HP:0003302)1.65114215
150Mitral stenosis (HP:0001718)1.65061422
151Mucosal telangiectasiae (HP:0100579)1.65013105
152Abnormal eating behavior (HP:0100738)1.63890212
153Keratoconjunctivitis (HP:0001096)1.63796538
154Inappropriate behavior (HP:0000719)1.63083962
155Gowers sign (HP:0003391)1.62678100
156Clonus (HP:0002169)1.62311383
157Myoclonus (HP:0001336)1.61029747
158Axonal loss (HP:0003447)1.60588508
159Poor speech (HP:0002465)1.59773605
160Spinal muscular atrophy (HP:0007269)1.59332298
161Abnormality of the lumbar spine (HP:0100712)1.58710375
162Increased CSF protein (HP:0002922)1.58337086
163Rigidity (HP:0002063)1.58285150
164Myokymia (HP:0002411)1.57961117
165Generalized myoclonic seizures (HP:0002123)1.57592219
166Agitation (HP:0000713)1.57567830
167Keratoconjunctivitis sicca (HP:0001097)1.57535099
168Thyroid carcinoma (HP:0002890)1.57281946
169T lymphocytopenia (HP:0005403)1.57131690
170Abnormality of T cell number (HP:0011839)1.57078395
171Decreased central vision (HP:0007663)1.56684872
172Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.56407918
173J-shaped sella turcica (HP:0002680)1.55334196
174Metaphyseal dysplasia (HP:0100255)1.55180039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT4.26320493
2MAP3K34.22951256
3MAP2K34.21659570
4FRK3.49684515
5RIPK42.75642104
6PRKD22.57425659
7PRKCH2.53145804
8INSRR2.48393419
9ADRBK22.47161514
10CASK2.47028614
11SGK22.35965346
12MAP3K122.24506068
13MAPKAPK52.22785322
14ACVR1B2.22281152
15TAOK32.16888601
16SGK2232.11659812
17SGK4942.11659812
18CDK192.09302650
19NTRK32.02076335
20TXK1.95185883
21STK241.92393307
22MAP3K131.91637989
23SGK31.71316638
24STK38L1.66916856
25IRAK31.66331459
26FER1.65614804
27MAP2K71.64388089
28MAP3K141.61266235
29MUSK1.60756415
30MAP3K41.58824662
31TRIB31.55952858
32CAMKK21.49912418
33SYK1.48460522
34TNIK1.42897056
35MARK31.42183977
36EPHB11.41310810
37FES1.40346992
38BMPR1B1.36692683
39MAP4K21.34613236
40IRAK11.27530536
41NTRK11.24043003
42OXSR11.21500296
43MAP3K91.19219851
44DDR21.16182240
45STK31.16167867
46PRPF4B1.16007603
47PDK21.15144668
48STK391.13280420
49TGFBR21.10864732
50MAP4K11.09133985
51PRKCE1.08629128
52CSK1.08320028
53EPHA41.05865789
54TRIM281.03638001
55BLK1.03086444
56SCYL21.00490684
57IKBKB0.99629356
58BCR0.97390490
59FGR0.96778115
60ZAP700.95701165
61ABL20.91548937
62MST40.89371548
63TBK10.88979490
64GRK70.88575502
65JAK10.86167338
66MAP3K50.85159341
67BMPR20.84330139
68IKBKE0.83269905
69JAK30.80989006
70PINK10.79897647
71KSR10.78920833
72MOS0.78398150
73CDK50.77837944
74MAPKAPK30.76963241
75PTK2B0.76614512
76PLK20.75841525
77SIK30.74730066
78CSNK1G20.74553020
79ADRBK10.74340778
80TRPM70.74081038
81CSNK1A1L0.73244308
82GRK50.73127664
83CAMKK10.72788544
84TGFBR10.71280756
85GRK10.69083511
86MAP2K40.68993089
87MAPK130.67823689
88HCK0.67802225
89NEK90.66592362
90LCK0.66131638
91MAP3K20.65609041
92CDK60.65006962
93ABL10.64778918
94IRAK20.64299339
95EPHA30.64006413
96CSNK1G30.63992212
97LIMK10.63813187
98IGF1R0.63653081
99PIK3CG0.63569526
100MINK10.63420539
101GRK60.63199889
102PDK10.61936350
103NEK60.61710019
104PAK60.60962531
105IRAK40.59316376
106CAMK2B0.58388658
107FYN0.58161595
108MAPK120.57762024
109EGFR0.56167313
110PDPK10.55518356
111LYN0.54243178
112CAMK2A0.53941104
113WEE10.53233783
114CSNK1G10.52674358
115MAP2K60.52542571
116MAP3K60.51420434
117ARAF0.51265462
118TIE10.50756546
119TNK20.50574789
120ERBB40.50183788
121PRKCQ0.49857114
122PRKAA20.49477830
123EIF2AK30.49424980
124KSR20.47658750
125MAPK70.46527349
126MARK10.45778291
127WNK10.45337451
128SGK10.45098043
129ITK0.44950013
130PKN10.44486242
131HIPK20.44311793
132RET0.43832731
133MATK0.42518104
134PRKD10.41674548
135DAPK10.41575209
136PAK30.41397502
137FGFR30.41026712
138MAP2K10.40516726
139CSF1R0.39665023
140MYLK0.38736841
141BTK0.36715443
142GSK3A0.36175139
143TEC0.36113395
144JAK20.35254717
145CAMK2D0.35248478
146PAK20.34605317
147TYK20.34451705
148ERBB30.33512931

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysosome_Homo sapiens_hsa041422.52081617
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.35964142
3Collecting duct acid secretion_Homo sapiens_hsa049662.35372458
4Synaptic vesicle cycle_Homo sapiens_hsa047212.27974717
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.01111475
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.90526531
7Vibrio cholerae infection_Homo sapiens_hsa051101.84918510
8Rheumatoid arthritis_Homo sapiens_hsa053231.80875076
9Nicotine addiction_Homo sapiens_hsa050331.77342201
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72076776
11Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.68252621
12Other glycan degradation_Homo sapiens_hsa005111.57544388
13Serotonergic synapse_Homo sapiens_hsa047261.55852688
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54664976
15Glutamatergic synapse_Homo sapiens_hsa047241.53500182
16Phagosome_Homo sapiens_hsa041451.51712663
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.50443304
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46320324
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45300746
20Long-term potentiation_Homo sapiens_hsa047201.44946158
21Morphine addiction_Homo sapiens_hsa050321.43505601
22Sulfur metabolism_Homo sapiens_hsa009201.42172219
23Sphingolipid metabolism_Homo sapiens_hsa006001.41975864
24GABAergic synapse_Homo sapiens_hsa047271.40422190
25TNF signaling pathway_Homo sapiens_hsa046681.40194048
26Staphylococcus aureus infection_Homo sapiens_hsa051501.39445174
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31319459
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30456434
29Olfactory transduction_Homo sapiens_hsa047401.30304131
30Legionellosis_Homo sapiens_hsa051341.27791432
31Salivary secretion_Homo sapiens_hsa049701.27612754
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25255503
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.24009081
34Circadian entrainment_Homo sapiens_hsa047131.23249634
35Tuberculosis_Homo sapiens_hsa051521.22386657
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18335763
37Protein export_Homo sapiens_hsa030601.17625877
38Toxoplasmosis_Homo sapiens_hsa051451.16986264
39Amphetamine addiction_Homo sapiens_hsa050311.15718341
40Dopaminergic synapse_Homo sapiens_hsa047281.14592672
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.14071077
42GnRH signaling pathway_Homo sapiens_hsa049121.14049226
43Hematopoietic cell lineage_Homo sapiens_hsa046401.14017432
44Taste transduction_Homo sapiens_hsa047421.10065455
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10033808
46Leishmaniasis_Homo sapiens_hsa051401.09149430
47Renin secretion_Homo sapiens_hsa049241.08932358
48Graft-versus-host disease_Homo sapiens_hsa053321.05216337
49Cholinergic synapse_Homo sapiens_hsa047251.03266966
50Long-term depression_Homo sapiens_hsa047301.02543870
51Sphingolipid signaling pathway_Homo sapiens_hsa040711.02208604
52Osteoclast differentiation_Homo sapiens_hsa043801.01312303
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99857391
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99207867
55Platelet activation_Homo sapiens_hsa046110.97868520
56B cell receptor signaling pathway_Homo sapiens_hsa046620.97662090
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97493839
58Allograft rejection_Homo sapiens_hsa053300.96069404
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95528989
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95319332
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94344063
62Calcium signaling pathway_Homo sapiens_hsa040200.93534846
63Malaria_Homo sapiens_hsa051440.93311143
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.91767255
65Insulin secretion_Homo sapiens_hsa049110.90336188
66Chemokine signaling pathway_Homo sapiens_hsa040620.89923608
67Gastric acid secretion_Homo sapiens_hsa049710.89147203
68T cell receptor signaling pathway_Homo sapiens_hsa046600.88755225
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86726638
70Ether lipid metabolism_Homo sapiens_hsa005650.86724549
71Cocaine addiction_Homo sapiens_hsa050300.86312572
72Oxytocin signaling pathway_Homo sapiens_hsa049210.84599419
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83932082
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.82274484
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81982205
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.81449981
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78199540
78Salmonella infection_Homo sapiens_hsa051320.76490142
79MAPK signaling pathway_Homo sapiens_hsa040100.76080974
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75920221
81Pancreatic secretion_Homo sapiens_hsa049720.75701972
82Amoebiasis_Homo sapiens_hsa051460.74680994
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74238342
84Choline metabolism in cancer_Homo sapiens_hsa052310.73654068
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72979451
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72638960
87Pertussis_Homo sapiens_hsa051330.72392437
88Endocytosis_Homo sapiens_hsa041440.71311395
89Ras signaling pathway_Homo sapiens_hsa040140.69388124
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68847347
91Steroid biosynthesis_Homo sapiens_hsa001000.68495747
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.67671364
93Mineral absorption_Homo sapiens_hsa049780.67609412
94Type II diabetes mellitus_Homo sapiens_hsa049300.66491395
95Shigellosis_Homo sapiens_hsa051310.65696396
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64951543
97Dorso-ventral axis formation_Homo sapiens_hsa043200.64743813
98Antigen processing and presentation_Homo sapiens_hsa046120.64158208
99Prolactin signaling pathway_Homo sapiens_hsa049170.64137532
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.62906684
101Autoimmune thyroid disease_Homo sapiens_hsa053200.62420744
102ErbB signaling pathway_Homo sapiens_hsa040120.62108132
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61155787
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61119997
105Measles_Homo sapiens_hsa051620.60437594
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60434673
107Axon guidance_Homo sapiens_hsa043600.60398311
108Thyroid hormone synthesis_Homo sapiens_hsa049180.59881005
109Fatty acid biosynthesis_Homo sapiens_hsa000610.59550020
110Hepatitis B_Homo sapiens_hsa051610.57620860
111Glioma_Homo sapiens_hsa052140.56652563
112cAMP signaling pathway_Homo sapiens_hsa040240.55957315
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55389695
114Influenza A_Homo sapiens_hsa051640.54828699
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53567428
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52819106
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52326444
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51913382
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.51448105
120Small cell lung cancer_Homo sapiens_hsa052220.51342237
121ECM-receptor interaction_Homo sapiens_hsa045120.51241678
122VEGF signaling pathway_Homo sapiens_hsa043700.51087621
123Primary immunodeficiency_Homo sapiens_hsa053400.50600358
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50480690
125African trypanosomiasis_Homo sapiens_hsa051430.49745495
126Focal adhesion_Homo sapiens_hsa045100.49434479
127Type I diabetes mellitus_Homo sapiens_hsa049400.48538121
128Prion diseases_Homo sapiens_hsa050200.48411363
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48174334
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48016358
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47863042
132Regulation of autophagy_Homo sapiens_hsa041400.47687596
133Melanoma_Homo sapiens_hsa052180.47609756
134Tryptophan metabolism_Homo sapiens_hsa003800.46360922
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.46133915
136mTOR signaling pathway_Homo sapiens_hsa041500.45923148
137Fatty acid elongation_Homo sapiens_hsa000620.45346262
138FoxO signaling pathway_Homo sapiens_hsa040680.44972373
139Viral myocarditis_Homo sapiens_hsa054160.44337177
140Asthma_Homo sapiens_hsa053100.41466967
141PPAR signaling pathway_Homo sapiens_hsa033200.40339549
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40271098
143Ovarian steroidogenesis_Homo sapiens_hsa049130.38940479
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38940108
145Rap1 signaling pathway_Homo sapiens_hsa040150.37431203
146Herpes simplex infection_Homo sapiens_hsa051680.36529642
147Maturity onset diabetes of the young_Homo sapiens_hsa049500.36404724

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