OSTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urinary tract smooth muscle contraction (GO:0014848)9.33246223
2regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO9.30312781
3muscle filament sliding (GO:0030049)8.82263363
4actin-myosin filament sliding (GO:0033275)8.82263363
5regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)8.52449187
6skeletal muscle contraction (GO:0003009)8.27141210
7regulation of skeletal muscle contraction (GO:0014819)7.84449970
8sarcoplasmic reticulum calcium ion transport (GO:0070296)7.77412154
9actin-mediated cell contraction (GO:0070252)7.41037151
10growth hormone secretion (GO:0030252)7.29337573
11negative regulation of cardiac muscle cell apoptotic process (GO:0010667)7.26719531
12skeletal muscle adaptation (GO:0043501)6.68039817
13cell communication by electrical coupling involved in cardiac conduction (GO:0086064)6.62248228
14tonic smooth muscle contraction (GO:0014820)6.46608131
15cranial nerve structural organization (GO:0021604)6.29305861
16motile cilium assembly (GO:0044458)6.14241435
17smooth muscle contraction (GO:0006939)6.09852142
18positive regulation of cardiac muscle cell differentiation (GO:2000727)6.04804299
19negative regulation of myotube differentiation (GO:0010832)5.83378503
20positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)5.81702027
21cell communication by electrical coupling (GO:0010644)5.51112695
22actin filament-based movement (GO:0030048)5.48503742
23hypotonic response (GO:0006971)5.41000920
24cytidine metabolic process (GO:0046087)5.28331987
25cytidine catabolic process (GO:0006216)5.28331987
26cytidine deamination (GO:0009972)5.28331987
27regulation of cell communication by electrical coupling (GO:0010649)5.16729287
28skeletal muscle fiber development (GO:0048741)5.14675060
29regulation of skeletal muscle cell differentiation (GO:2001014)5.08711691
30extracellular matrix assembly (GO:0085029)5.06596117
31nucleus localization (GO:0051647)5.04138562
32pyrimidine ribonucleoside catabolic process (GO:0046133)5.02501674
33interkinetic nuclear migration (GO:0022027)4.99399500
34myotube cell development (GO:0014904)4.98562923
35positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.95603144
36cellular response to epinephrine stimulus (GO:0071872)4.90369448
37polyketide metabolic process (GO:0030638)4.85462668
38doxorubicin metabolic process (GO:0044598)4.85462668
39daunorubicin metabolic process (GO:0044597)4.85462668
40positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.77329381
41anatomical structure arrangement (GO:0048532)4.64618567
42response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.60366302
43response to muscle activity (GO:0014850)4.57455749
44positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.55880517
45regulation of cardiac muscle cell differentiation (GO:2000725)4.52830269
46negative regulation of striated muscle cell apoptotic process (GO:0010664)4.50482787
47regulation of smooth muscle cell differentiation (GO:0051150)4.49209783
48striated muscle contraction (GO:0006941)4.39357359
49skeletal muscle tissue regeneration (GO:0043403)4.35239948
50SMAD protein complex assembly (GO:0007183)4.34492301
51cilium movement (GO:0003341)4.31993354
52regulation of alkaline phosphatase activity (GO:0010692)4.23317285
53smooth muscle tissue development (GO:0048745)4.21950978
54sarcomere organization (GO:0045214)4.19087914
55regulation of voltage-gated calcium channel activity (GO:1901385)4.18331472
56regulation of cardiac muscle contraction (GO:0055117)4.14484600
57positive regulation of SMAD protein import into nucleus (GO:0060391)4.14141764
58response to epinephrine (GO:0071871)4.13453443
59regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.05386900
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.05176834
61regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.04399662
62calcium ion transport into cytosol (GO:0060402)4.01209985
63regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.91223538
64cytosolic calcium ion transport (GO:0060401)3.88720735
65purine nucleotide salvage (GO:0032261)3.88567200
66glycogen catabolic process (GO:0005980)3.88372040
67positive regulation of cation channel activity (GO:2001259)3.88051138
68cardiac cell development (GO:0055006)3.87871604
69respiratory electron transport chain (GO:0022904)3.86828593
70heart valve formation (GO:0003188)3.84162445
71striated muscle atrophy (GO:0014891)3.83041426
72cAMP catabolic process (GO:0006198)3.80187792
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.78123579
74myofibril assembly (GO:0030239)3.77420227
75neuronal action potential propagation (GO:0019227)3.76831988
76smooth muscle cell differentiation (GO:0051145)3.76227284
77relaxation of smooth muscle (GO:0044557)3.73157737
78cardiac myofibril assembly (GO:0055003)3.72433348
79muscle contraction (GO:0006936)3.72359629
80electron transport chain (GO:0022900)3.72045777
81Notch signaling involved in heart development (GO:0061314)3.71623403
82energy coupled proton transport, down electrochemical gradient (GO:0015985)3.71590933
83ATP synthesis coupled proton transport (GO:0015986)3.71590933
84regulation of cardiac muscle cell apoptotic process (GO:0010665)3.71446252
85plasma membrane repair (GO:0001778)3.66124746
86response to hepatocyte growth factor (GO:0035728)3.64846276
87cellular response to hepatocyte growth factor stimulus (GO:0035729)3.64846276
88glucan catabolic process (GO:0009251)3.61533265
89negative regulation of skeletal muscle tissue development (GO:0048642)3.61032598
90muscle atrophy (GO:0014889)3.59005693
91sequestering of extracellular ligand from receptor (GO:0035581)3.58975108
92calcium ion import (GO:0070509)3.55887468
93glycogen biosynthetic process (GO:0005978)3.53539925
94glucan biosynthetic process (GO:0009250)3.53539925
95regulation of calcium ion transmembrane transporter activity (GO:1901019)3.51295125
96regulation of calcium ion transmembrane transport (GO:1903169)3.51295125
97cyclic nucleotide catabolic process (GO:0009214)3.48947197
98positive regulation of sodium ion transmembrane transport (GO:1902307)3.46739033
99positive regulation of phosphatase activity (GO:0010922)3.46668958
100regulation of muscle contraction (GO:0006937)3.45206103
101striated muscle adaptation (GO:0014888)3.44884076
102uterus development (GO:0060065)3.44534035
103regulation of striated muscle contraction (GO:0006942)3.41369713
104cell communication involved in cardiac conduction (GO:0086065)3.40956850
105cardiac ventricle formation (GO:0003211)3.38795833
106cellular polysaccharide catabolic process (GO:0044247)3.37295561
107creatine metabolic process (GO:0006600)3.35525612
108muscle system process (GO:0003012)3.35235396
109regulation of release of sequestered calcium ion into cytosol (GO:0051279)3.32769771
110regulation of SMAD protein import into nucleus (GO:0060390)3.32443668
111negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.31295282
112positive regulation of ion transmembrane transporter activity (GO:0032414)3.30949059
113cardiac muscle cell development (GO:0055013)3.30885954
114response to gravity (GO:0009629)3.29508978
115polysaccharide catabolic process (GO:0000272)3.28635466
116negative regulation of inclusion body assembly (GO:0090084)3.27712706
117mesodermal cell differentiation (GO:0048333)3.27377246
118response to inactivity (GO:0014854)3.25294257
119regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.24548467
120negative regulation of muscle hypertrophy (GO:0014741)3.18824855
121carnitine shuttle (GO:0006853)3.18669801
122central nervous system projection neuron axonogenesis (GO:0021952)3.18177303
123regulation of relaxation of muscle (GO:1901077)3.16450242
124muscle fiber development (GO:0048747)3.15557672
125regulation of muscle system process (GO:0090257)3.14190268
126response to activity (GO:0014823)3.13300078
127muscle adaptation (GO:0043500)3.12629851
128regulation of activation of Janus kinase activity (GO:0010533)3.12533062
129negative regulation of nitric oxide biosynthetic process (GO:0045019)3.12400467
130regulation of myoblast differentiation (GO:0045661)3.09209492
131glomerular filtration (GO:0003094)3.08586810
132neuromuscular synaptic transmission (GO:0007274)3.07203057
133mesenchymal-epithelial cell signaling (GO:0060638)3.07095232
134cardiac chamber formation (GO:0003207)3.06510255
135regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.04213006
136cGMP-mediated signaling (GO:0019934)3.03277954
137regulation of sarcomere organization (GO:0060297)3.01052513
138epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.00330181
139mitochondrial genome maintenance (GO:0000002)2.99180700
140regulation of cardiac muscle cell contraction (GO:0086004)2.98739853
141cranial nerve morphogenesis (GO:0021602)2.98704882
142positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.98665922
143cartilage morphogenesis (GO:0060536)2.97552780
144coronary vasculature morphogenesis (GO:0060977)2.96685658
145regulation of cation channel activity (GO:2001257)2.96547289
146eosinophil chemotaxis (GO:0048245)2.96541797
147membrane depolarization during action potential (GO:0086010)2.95796023
148determination of left/right symmetry (GO:0007368)2.94141790
149regulation of cardiac muscle tissue development (GO:0055024)2.93665268
150inositol metabolic process (GO:0006020)2.93278053
151response to dietary excess (GO:0002021)2.92614497
152actomyosin structure organization (GO:0031032)2.92064135
153regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.90113725
154negative regulation of smooth muscle cell differentiation (GO:0051151)2.89560798
155regulation of striated muscle cell apoptotic process (GO:0010662)2.88575622
156muscle structure development (GO:0061061)2.86838615
157muscle organ development (GO:0007517)2.85684896
158skeletal muscle tissue development (GO:0007519)2.85079156
159muscle cell cellular homeostasis (GO:0046716)2.81841985
160aminoglycoside antibiotic metabolic process (GO:0030647)2.81295936
161negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.81254005
162negative regulation of protein localization to cell surface (GO:2000009)2.77292971
163regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.71777842
164regulation of acyl-CoA biosynthetic process (GO:0050812)2.71524442
165positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.71364549
166regulation of pseudopodium assembly (GO:0031272)2.69605044
167neuron fate determination (GO:0048664)2.66218346
168negative regulation of myoblast differentiation (GO:0045662)2.65542288
169regulation of actin filament-based movement (GO:1903115)2.65229489
170myoblast fusion (GO:0007520)2.62559445
171adenosine metabolic process (GO:0046085)2.61648596
172quinone biosynthetic process (GO:1901663)2.57699606
173ubiquinone biosynthetic process (GO:0006744)2.57699606
174cellular response to dexamethasone stimulus (GO:0071549)2.56422906
175negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.55992344
176positive regulation of Rho protein signal transduction (GO:0035025)2.55822042
177regulation of memory T cell differentiation (GO:0043380)2.55778318
178cellular ketone body metabolic process (GO:0046950)2.54436391
179positive regulation of mitochondrial fission (GO:0090141)2.52587758
180otic vesicle formation (GO:0030916)2.52457507
181detection of molecule of bacterial origin (GO:0032490)2.52322863
182eosinophil migration (GO:0072677)2.50804607
183positive regulation of interleukin-1 secretion (GO:0050716)2.50680584
184mitochondrial calcium ion homeostasis (GO:0051560)2.50049562
185ADP metabolic process (GO:0046031)2.49119906
186myotube differentiation (GO:0014902)2.49114732
187regulation of skeletal muscle fiber development (GO:0048742)2.47632377
188regulation of respiratory burst (GO:0060263)2.45934087
189regulation of hydrogen peroxide metabolic process (GO:0010310)2.45839614
190positive regulation of prostaglandin secretion (GO:0032308)2.45116455

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.20494752
2EZH2_22144423_ChIP-Seq_EOC_Human4.10404323
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.63166347
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.38129172
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.21913446
6GBX2_23144817_ChIP-Seq_PC3_Human2.94162087
7TP53_16413492_ChIP-PET_HCT116_Human2.87527288
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.77465783
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.47952895
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41858955
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.37572920
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35006559
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.32905529
14VDR_22108803_ChIP-Seq_LS180_Human2.27846237
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.26829925
16* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.19704832
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16828157
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16106047
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.15842228
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.13741621
21* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.12764428
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10510360
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07240118
24EWS_26573619_Chip-Seq_HEK293_Human2.05468428
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03574620
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00683260
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99863858
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99863858
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.97911424
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87707883
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.87521076
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87222779
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85936833
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.83878769
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79334228
36CTNNB1_20460455_ChIP-Seq_HCT116_Human1.73573904
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73251659
38AR_21572438_ChIP-Seq_LNCaP_Human1.71347532
39FUS_26573619_Chip-Seq_HEK293_Human1.68448103
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67724723
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66147381
42ER_23166858_ChIP-Seq_MCF-7_Human1.65577393
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65504248
44STAT3_23295773_ChIP-Seq_U87_Human1.61730054
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.57674935
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56392952
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54469327
48BCAT_22108803_ChIP-Seq_LS180_Human1.53905728
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.53506946
50* TCF4_23295773_ChIP-Seq_U87_Human1.52466342
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51843594
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50689460
53P300_19829295_ChIP-Seq_ESCs_Human1.48740593
54* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46212786
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.46075816
56CJUN_26792858_Chip-Seq_BT549_Human1.45553528
57YAP1_20516196_ChIP-Seq_MESCs_Mouse1.43671462
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43189869
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.36305777
60TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34507759
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.32879266
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.32318682
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31834469
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31079919
65TP53_18474530_ChIP-ChIP_U2OS_Human1.30923976
66JUN_21703547_ChIP-Seq_K562_Human1.30716558
67SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30345580
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30021037
69* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28243606
70TP53_20018659_ChIP-ChIP_R1E_Mouse1.27876730
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27434669
72SOX9_26525672_Chip-Seq_HEART_Mouse1.27253017
73* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26988599
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26209746
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.25948883
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25556615
77DROSHA_22980978_ChIP-Seq_HELA_Human1.25146079
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.23225619
79* RNF2_27304074_Chip-Seq_NSC_Mouse1.22004794
80P53_22387025_ChIP-Seq_ESCs_Mouse1.21637934
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.20948393
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20394872
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.19609306
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.19499707
85* RUNX2_22187159_ChIP-Seq_PCA_Human1.18971798
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18625641
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18528049
88ZNF274_21170338_ChIP-Seq_K562_Hela1.17326610
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16545621
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16396771
91KDM2B_26808549_Chip-Seq_REH_Human1.16245312
92GATA1_26923725_Chip-Seq_HPCs_Mouse1.15777775
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14411624
94CBP_20019798_ChIP-Seq_JUKART_Human1.14411624
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13478340
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.12260024
97SMAD4_21799915_ChIP-Seq_A2780_Human1.12175743
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.12111758
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12018560
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.11950149
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11774039
102* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09781358
103IGF1R_20145208_ChIP-Seq_DFB_Human1.09260727
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.06395437
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06379599
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.06234085
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06087618
108SOX2_18555785_Chip-Seq_ESCs_Mouse1.05997419
109ZFX_18555785_Chip-Seq_ESCs_Mouse1.05472683
110AR_19668381_ChIP-Seq_PC3_Human1.05457989
111ARNT_22903824_ChIP-Seq_MCF-7_Human1.04786773
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04784228
113RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04010670
114SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03583744
115RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03323817
116NMYC_18555785_Chip-Seq_ESCs_Mouse1.03276883
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03215420
118CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03202336
119* AR_25329375_ChIP-Seq_VCAP_Human1.02846310
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02175144
121* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02102886
122NANOG_19829295_ChIP-Seq_ESCs_Human1.01638281
123SOX2_19829295_ChIP-Seq_ESCs_Human1.01638281
124TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00319729
125PU1_27457419_Chip-Seq_LIVER_Mouse0.99715973
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99492866
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99149292
128OCT4_18555785_Chip-Seq_ESCs_Mouse0.98988267
129OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98648379
130P300_18555785_Chip-Seq_ESCs_Mouse0.98098295
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97915262
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97605288
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97605288
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97182984
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97182984
136SMAD3_21741376_ChIP-Seq_HESCs_Human0.97132632
137CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96892253
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96299891
139TAF15_26573619_Chip-Seq_HEK293_Human0.95244367
140REST_21632747_ChIP-Seq_MESCs_Mouse0.94470148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio6.55574633
2MP0003646_muscle_fatigue6.18522312
3MP0000749_muscle_degeneration5.15218467
4MP0000751_myopathy4.23001480
5MP0003045_fibrosis3.55532875
6MP0002106_abnormal_muscle_physiology3.24043621
7MP0004036_abnormal_muscle_relaxation3.05030587
8MP0005369_muscle_phenotype2.99425299
9MP0005503_abnormal_tendon_morphology2.87534297
10MP0004130_abnormal_muscle_cell2.84451766
11MP0000759_abnormal_skeletal_muscle2.81136554
12MP0002168_other_aberrant_phenotype2.78603200
13MP0002837_dystrophic_cardiac_calcinosis2.67425288
14MP0005620_abnormal_muscle_contractility2.61301943
15MP0003183_abnormal_peptide_metabolism2.54127588
16MP0000747_muscle_weakness2.48676986
17MP0002108_abnormal_muscle_morphology2.47956421
18MP0003705_abnormal_hypodermis_morpholog2.18445117
19MP0004087_abnormal_muscle_fiber2.17120977
20MP0008004_abnormal_stomach_pH2.10221335
21MP0002332_abnormal_exercise_endurance2.08917871
22MP0000534_abnormal_ureter_morphology2.07657964
23MP0002277_abnormal_respiratory_mucosa2.05790524
24MP0001661_extended_life_span2.01682791
25MP0002269_muscular_atrophy2.00328193
26MP0001984_abnormal_olfaction1.97560631
27MP0004233_abnormal_muscle_weight1.81778257
28MP0004272_abnormal_basement_membrane1.81186963
29MP0000750_abnormal_muscle_regeneration1.79457216
30MP0004484_altered_response_of1.77098764
31MP0002127_abnormal_cardiovascular_syste1.70216743
32MP0006276_abnormal_autonomic_nervous1.65760677
33MP0000566_synostosis1.63524799
34MP0009250_abnormal_appendicular_skeleto1.60260298
35MP0006292_abnormal_olfactory_placode1.59668107
36MP0003941_abnormal_skin_development1.58033978
37MP0003879_abnormal_hair_cell1.53851802
38MP0009697_abnormal_copulation1.52288483
39MP0001270_distended_abdomen1.51122200
40MP0000767_abnormal_smooth_muscle1.50374308
41MP0003942_abnormal_urinary_system1.49166392
42MP0005395_other_phenotype1.42965439
43MP0000569_abnormal_digit_pigmentation1.42701954
44MP0000778_abnormal_nervous_system1.38591458
45MP0010352_gastrointestinal_tract_polyps1.35115440
46MP0002132_abnormal_respiratory_system1.33724043
47MP0004134_abnormal_chest_morphology1.31000878
48MP0003880_abnormal_central_pattern1.30731801
49MP0000013_abnormal_adipose_tissue1.29497674
50MP0003283_abnormal_digestive_organ1.29374734
51MP0006036_abnormal_mitochondrial_physio1.28648551
52MP0002148_abnormal_hypersensitivity_rea1.28258066
53MP0000733_abnormal_muscle_development1.27889744
54MP0005377_hearing/vestibular/ear_phenot1.26952531
55MP0003878_abnormal_ear_physiology1.26952531
56MP0004085_abnormal_heartbeat1.26207025
57MP0000230_abnormal_systemic_arterial1.25909616
58MP0002063_abnormal_learning/memory/cond1.20929210
59MP0010386_abnormal_urinary_bladder1.19492235
60MP0009785_altered_susceptibility_to1.19430884
61MP0004215_abnormal_myocardial_fiber1.18896096
62MP0005171_absent_coat_pigmentation1.18708847
63MP0000372_irregular_coat_pigmentation1.17566782
64MP0001756_abnormal_urination1.17231512
65MP0000631_abnormal_neuroendocrine_gland1.15723966
66MP0002972_abnormal_cardiac_muscle1.13898677
67MP0002638_abnormal_pupillary_reflex1.11283582
68MP0005646_abnormal_pituitary_gland1.10545428
69MP0005187_abnormal_penis_morphology1.08768022
70MP0004142_abnormal_muscle_tone1.07517975
71MP0000579_abnormal_nail_morphology1.05626187
72MP0005330_cardiomyopathy1.04788154
73MP0003252_abnormal_bile_duct1.00876077
74MP0003279_aneurysm1.00656180
75MP0003890_abnormal_embryonic-extraembry1.00380383
76MP0000762_abnormal_tongue_morphology0.98598296
77MP0005645_abnormal_hypothalamus_physiol0.97902858
78MP0001440_abnormal_grooming_behavior0.94480828
79MP0004147_increased_porphyrin_level0.94420104
80MP0002928_abnormal_bile_duct0.93099392
81MP0009384_cardiac_valve_regurgitation0.93023888
82MP0003137_abnormal_impulse_conducting0.92986668
83MP0002736_abnormal_nociception_after0.92397334
84MP0002163_abnormal_gland_morphology0.91975008
85MP0004782_abnormal_surfactant_physiolog0.90725406
86MP0001968_abnormal_touch/_nociception0.90692752
87MP0001970_abnormal_pain_threshold0.90100124
88MP0002572_abnormal_emotion/affect_behav0.89973060
89MP0010630_abnormal_cardiac_muscle0.87911993
90MP0004859_abnormal_synaptic_plasticity0.85554140
91MP0002734_abnormal_mechanical_nocicepti0.85514356
92MP0003937_abnormal_limbs/digits/tail_de0.85126924
93MP0004043_abnormal_pH_regulation0.83959144
94MP0009745_abnormal_behavioral_response0.82283526
95MP0003950_abnormal_plasma_membrane0.81307219
96MP0006082_CNS_inflammation0.79977701
97MP0005670_abnormal_white_adipose0.79924411
98MP0003385_abnormal_body_wall0.79354170
99MP0009780_abnormal_chondrocyte_physiolo0.79323475
100MP0001879_abnormal_lymphatic_vessel0.79289782
101MP0002067_abnormal_sensory_capabilities0.78872548
102MP0004742_abnormal_vestibular_system0.77889572
103MP0004084_abnormal_cardiac_muscle0.74566764
104MP0001542_abnormal_bone_strength0.73975317
105MP0000516_abnormal_urinary_system0.73914475
106MP0005367_renal/urinary_system_phenotyp0.73914475
107MP0001486_abnormal_startle_reflex0.73814317
108MP0000678_abnormal_parathyroid_gland0.72171022
109MP0001664_abnormal_digestion0.71576198
110MP0001346_abnormal_lacrimal_gland0.71531061
111MP0005595_abnormal_vascular_smooth0.70633209
112MP0005275_abnormal_skin_tensile0.69360356
113MP0002733_abnormal_thermal_nociception0.69182177
114MP0009046_muscle_twitch0.69174021
115MP0002735_abnormal_chemical_nociception0.68164902
116MP0010030_abnormal_orbit_morphology0.67370128
117MP0002896_abnormal_bone_mineralization0.67279707
118MP0008057_abnormal_DNA_replication0.67034436
119MP0006138_congestive_heart_failure0.65405340
120MP0005508_abnormal_skeleton_morphology0.64937554
121MP0005253_abnormal_eye_physiology0.64888367
122MP0002089_abnormal_postnatal_growth/wei0.64191710
123MP0003938_abnormal_ear_development0.64050743
124MP0003195_calcinosis0.64002587
125MP0001501_abnormal_sleep_pattern0.62957698
126MP0001943_abnormal_respiration0.62774565
127MP0005166_decreased_susceptibility_to0.61584240
128MP0008438_abnormal_cutaneous_collagen0.61197717
129MP0003633_abnormal_nervous_system0.61142600
130MP0005266_abnormal_metabolism0.61019104
131MP0000026_abnormal_inner_ear0.60999004
132MP0000427_abnormal_hair_cycle0.60871902
133MP0001485_abnormal_pinna_reflex0.60870344
134MP0002249_abnormal_larynx_morphology0.60649641
135MP0003453_abnormal_keratinocyte_physiol0.60573774
136MP0004270_analgesia0.60515741
137MP0003011_delayed_dark_adaptation0.60140821
138MP0000266_abnormal_heart_morphology0.59468273
139MP0001663_abnormal_digestive_system0.59408260
140MP0009764_decreased_sensitivity_to0.58531733
141MP0004811_abnormal_neuron_physiology0.58352793
142MP0000462_abnormal_digestive_system0.57377220
143MP0000049_abnormal_middle_ear0.57207844
144MP0010770_preweaning_lethality0.56746551
145MP0002082_postnatal_lethality0.56746551
146MP0002109_abnormal_limb_morphology0.55747247
147MP0003635_abnormal_synaptic_transmissio0.54919966
148MP0002128_abnormal_blood_circulation0.54842025
149MP0008569_lethality_at_weaning0.54383989
150MP0003315_abnormal_perineum_morphology0.53942792
151MP0002697_abnormal_eye_size0.53168789
152MP0005023_abnormal_wound_healing0.53103735
153MP0002184_abnormal_innervation0.52106903
154MP0001348_abnormal_lacrimal_gland0.52100173
155MP0002971_abnormal_brown_adipose0.51354816
156MP0000538_abnormal_urinary_bladder0.50851809
157MP0005381_digestive/alimentary_phenotyp0.50653074

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)9.30487592
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.29923926
3Nemaline bodies (HP:0003798)8.86565587
4Abnormal ciliary motility (HP:0012262)8.21536019
5Exercise-induced myalgia (HP:0003738)7.73030295
6Type 1 muscle fiber predominance (HP:0003803)7.12296565
7Aortic dissection (HP:0002647)6.91096717
8Exercise-induced muscle cramps (HP:0003710)6.81180104
9Distal arthrogryposis (HP:0005684)6.01900446
10Myopathic facies (HP:0002058)6.01497864
11Abnormal respiratory motile cilium physiology (HP:0012261)5.85131056
12Muscle hypertrophy of the lower extremities (HP:0008968)5.69141971
13Absent phalangeal crease (HP:0006109)5.33346846
14Round ear (HP:0100830)4.85110920
15Calf muscle hypertrophy (HP:0008981)4.84973157
16Calcaneovalgus deformity (HP:0001848)4.77350689
17Ulnar deviation of the wrist (HP:0003049)4.69695953
18Muscle stiffness (HP:0003552)4.67522856
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.62736879
20Short 4th metacarpal (HP:0010044)4.62736879
21Facial shape deformation (HP:0011334)4.47811978
22Potter facies (HP:0002009)4.47811978
23Abnormal finger flexion creases (HP:0006143)4.45381798
24Scanning speech (HP:0002168)4.39245914
25Muscle fiber splitting (HP:0003555)4.37308131
26Difficulty running (HP:0009046)4.29720924
27Deformed tarsal bones (HP:0008119)4.27068578
28Renal dysplasia (HP:0000110)4.16704185
29Myoglobinuria (HP:0002913)4.12190913
30Vertebral arch anomaly (HP:0008438)4.07866188
31EMG: myopathic abnormalities (HP:0003458)3.81580681
32Prolonged QT interval (HP:0001657)3.70607557
33Rhabdomyolysis (HP:0003201)3.59848358
34Abnormality of the 4th metacarpal (HP:0010012)3.51378709
35Myotonia (HP:0002486)3.48159024
36Aortic regurgitation (HP:0001659)3.42877357
37Hyporeflexia of lower limbs (HP:0002600)3.39111255
38Abnormality of the calf musculature (HP:0001430)3.38014637
39Abnormality of skeletal muscle fiber size (HP:0012084)3.19357556
40Hypoventilation (HP:0002791)3.09769910
41Rectal prolapse (HP:0002035)3.09409673
42Abnormality of the phalanges of the hallux (HP:0010057)3.09373732
43Rimmed vacuoles (HP:0003805)3.05091785
44Broad ribs (HP:0000885)3.04312703
45Malignant hyperthermia (HP:0002047)3.02851605
46Colon cancer (HP:0003003)3.00002881
47Atrial fibrillation (HP:0005110)2.98261044
48Nonprogressive disorder (HP:0003680)2.97312908
49Syncope (HP:0001279)2.93925378
50Aneurysm (HP:0002617)2.89843118
51Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.85090798
52Increased connective tissue (HP:0009025)2.83708988
53Neck muscle weakness (HP:0000467)2.82982564
54Neoplasm of the heart (HP:0100544)2.80448610
55Fair hair (HP:0002286)2.77658253
56Bicornuate uterus (HP:0000813)2.76744363
57Focal motor seizures (HP:0011153)2.75691736
58Increased variability in muscle fiber diameter (HP:0003557)2.74255475
59Cutaneous finger syndactyly (HP:0010554)2.73572517
60Primary atrial arrhythmia (HP:0001692)2.69337899
61Stroke (HP:0001297)2.65580086
62Supraventricular arrhythmia (HP:0005115)2.63283660
63Bicuspid aortic valve (HP:0001647)2.63027658
64Chorioretinal atrophy (HP:0000533)2.62569228
65Broad metatarsal (HP:0001783)2.61640390
66Fatigable weakness (HP:0003473)2.60829928
67Abnormality of the neuromuscular junction (HP:0003398)2.60829928
68Shallow orbits (HP:0000586)2.60694365
69Supraventricular tachycardia (HP:0004755)2.60020947
70Long nose (HP:0003189)2.59721002
71Narrow palate (HP:0000189)2.58298225
72Malnutrition (HP:0004395)2.55955588
73Preaxial foot polydactyly (HP:0001841)2.54531106
74Subaortic stenosis (HP:0001682)2.53156616
75Abnormality of the left ventricular outflow tract (HP:0011103)2.53156616
76Short metatarsal (HP:0010743)2.49813239
77Pulmonary artery stenosis (HP:0004415)2.48438222
78Increased intramyocellular lipid droplets (HP:0012240)2.43324577
79Mild short stature (HP:0003502)2.43011154
80Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.42398817
81Shoulder girdle muscle weakness (HP:0003547)2.40717044
82Pelvic girdle muscle weakness (HP:0003749)2.40106229
83Hyperkalemia (HP:0002153)2.39579268
84Areflexia of lower limbs (HP:0002522)2.38438361
85Abnormality of the hip-girdle musculature (HP:0001445)2.36998767
86Abnormality of the musculature of the pelvis (HP:0001469)2.36998767
87Vaginal atresia (HP:0000148)2.35158141
88Increased hepatocellular lipid droplets (HP:0006565)2.34740853
89Broad hallux (HP:0010055)2.34373275
90Abnormality of the calcaneus (HP:0008364)2.33988927
91Acute necrotizing encephalopathy (HP:0006965)2.33249197
92Frequent falls (HP:0002359)2.30503258
93Cerebral aneurysm (HP:0004944)2.30255746
94Abnormal mitochondria in muscle tissue (HP:0008316)2.29399263
95Genital tract atresia (HP:0001827)2.29027611
96Mesomelia (HP:0003027)2.27164831
97Weak cry (HP:0001612)2.26928233
98Paralysis (HP:0003470)2.25663960
99Exercise intolerance (HP:0003546)2.25637037
100Cutaneous syndactyly (HP:0012725)2.23087828
101Non-midline cleft lip (HP:0100335)2.22762934
102Hyperphosphatemia (HP:0002905)2.21376371
103Broad toe (HP:0001837)2.14169830
104Distal lower limb muscle weakness (HP:0009053)2.13506879
105Hematochezia (HP:0002573)2.12956482
106Mitochondrial inheritance (HP:0001427)2.11558986
107Increased muscle lipid content (HP:0009058)2.11180019
108Truncal ataxia (HP:0002078)2.10069130
109Abnormality of alanine metabolism (HP:0010916)2.09944713
110Hyperalaninemia (HP:0003348)2.09944713
111Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09944713
112Abdominal situs inversus (HP:0003363)2.06039104
113Abnormality of abdominal situs (HP:0011620)2.06039104
114Hypoplastic ischia (HP:0003175)2.03920448
115Slender build (HP:0001533)2.00088300
116Lipid accumulation in hepatocytes (HP:0006561)2.00010851
117Muscle fiber inclusion bodies (HP:0100299)10.0421720
118Tarsal synostosis (HP:0008368)1.99966560
119Impaired vibration sensation in the lower limbs (HP:0002166)1.98401491
120Impaired smooth pursuit (HP:0007772)1.98190459
121Hypoplasia of the maxilla (HP:0000327)1.98114873
122Chromsome breakage (HP:0040012)1.97684661
123Generalized hypopigmentation of hair (HP:0011358)1.97550449
124Hip contracture (HP:0003273)1.95926706
125Hydroureter (HP:0000072)1.95204750
126Urinary urgency (HP:0000012)1.95159480
127Type 2 muscle fiber atrophy (HP:0003554)1.94894732
1283-Methylglutaconic aciduria (HP:0003535)1.93416982
129Fetal akinesia sequence (HP:0001989)1.93199188
130Progressive macrocephaly (HP:0004481)1.92124511
131Synostosis involving bones of the feet (HP:0009140)1.91965768
132Synostosis involving bones of the lower limbs (HP:0009138)1.91965768
133Hepatoblastoma (HP:0002884)1.91726568
134Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.90804310
135Short 1st metacarpal (HP:0010034)1.90804310
136Difficulty climbing stairs (HP:0003551)1.89929706
137Papillary thyroid carcinoma (HP:0002895)1.89733525
138Childhood onset (HP:0011463)1.87527595
139Increased CSF lactate (HP:0002490)1.87157816
140Blue irides (HP:0000635)1.86428549
141Renal Fanconi syndrome (HP:0001994)1.86381619
142Broad phalanges of the hand (HP:0009768)1.84615830
143Preauricular pit (HP:0004467)1.84559450
144Periauricular skin pits (HP:0100277)1.84559450
145Abnormal EKG (HP:0003115)1.84072265
146Bronchiectasis (HP:0002110)1.83632938
147Asymmetric septal hypertrophy (HP:0001670)1.81868260
148Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.81262325
149Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80878601
150Muscular dystrophy (HP:0003560)1.80017961
151Acute encephalopathy (HP:0006846)1.79918005
152Hypokalemia (HP:0002900)1.79822459
153Bulbar palsy (HP:0001283)1.79154372
154Generalized muscle weakness (HP:0003324)1.78680924
155Mitral regurgitation (HP:0001653)1.78242098
156Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77807725
157Pancreatic cysts (HP:0001737)1.77416434
158Keratoconus (HP:0000563)1.76421818
159Increased corneal curvature (HP:0100692)1.76421818
160Left ventricular hypertrophy (HP:0001712)1.75956873
161Abnormality of potassium homeostasis (HP:0011042)1.75480018
162Coarctation of aorta (HP:0001680)1.75475035
163Increased density of long bones (HP:0006392)1.74452232
164Abnormality of the proximal phalanges of the hand (HP:0009834)1.73802260
165Waddling gait (HP:0002515)1.72793579
166Broad finger (HP:0001500)1.72636300
167Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72408181
168Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72006678
169Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72006678
170Limited hip movement (HP:0008800)1.71792463
171Follicular hyperkeratosis (HP:0007502)1.71595761
172Broad phalanx (HP:0006009)1.70094136
173Respiratory insufficiency due to muscle weakness (HP:0002747)1.68020486
174Abnormality of the ischium (HP:0003174)1.66891543
175Natal tooth (HP:0000695)1.66552077
176Short chin (HP:0000331)1.66145302
177Broad thumb (HP:0011304)1.65806356
178Facial hemangioma (HP:0000329)1.65208803
179Aplasia/Hypoplasia of the tongue (HP:0010295)1.64783141
180Broad-based gait (HP:0002136)1.64440639
181Ventricular arrhythmia (HP:0004308)1.63385958
182Distal lower limb amyotrophy (HP:0008944)1.63380997
183Fibular aplasia (HP:0002990)1.62786713
184Synostosis of carpal bones (HP:0005048)1.62528340
185Sudden death (HP:0001699)1.62506088
186Muscle fiber atrophy (HP:0100295)1.61720391
187Facial diplegia (HP:0001349)1.61519984
188Hyperventilation (HP:0002883)1.59283207
189Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.58804522
190Proximal amyotrophy (HP:0007126)1.58596734
191Limb-girdle muscle weakness (HP:0003325)1.57204859
192Respiratory difficulties (HP:0002880)1.56040434
193Ventricular tachycardia (HP:0004756)1.53601401
194Stridor (HP:0010307)1.52489883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.94786860
2NME14.78951009
3PHKG24.15224529
4PHKG14.15224529
5TTN3.78084961
6CASK2.69127437
7NLK2.58682927
8PIK3CG2.52239300
9PIK3CA2.46202216
10PAK22.37725635
11INSRR2.17358447
12MAP3K72.15928826
13SIK31.90928337
14PDK31.78861446
15PDK41.78861446
16ZAK1.72363691
17MAP3K121.72026576
18TRIB31.71680148
19CAMK1D1.68045721
20PIM21.60282730
21LMTK21.53662649
22MAP2K61.51025590
23PDK21.50786826
24PBK1.49493580
25MUSK1.47702290
26EPHB21.40741048
27CAMK1G1.36593051
28MELK1.32392760
29EPHA41.18308469
30MAPK121.17271852
31STK161.16785639
32ROCK11.15424737
33ERBB31.13917245
34TXK1.13022454
35ILK1.08313802
36PINK11.07864314
37BLK1.07150917
38CDC42BPA0.97498353
39WNK10.96469614
40MAPK40.96345124
41CAMK2G0.95308624
42PRKAA20.94483458
43BCR0.93300701
44STK240.92996351
45MAP2K30.91134734
46ARAF0.90850551
47FRK0.90360643
48MAP2K40.90170266
49MAP3K140.88788253
50PKN10.85085123
51DMPK0.84879020
52MAP2K20.82637765
53MARK10.82601069
54PTK20.81632377
55TRPM70.79844411
56ADRBK20.78646953
57BRAF0.76746207
58IRAK40.73952826
59PRKAA10.69426241
60NEK10.67758315
61VRK10.67668067
62ADRBK10.67417898
63BMPR20.66783889
64EIF2AK20.66307386
65NTRK30.66037292
66MYLK0.65219432
67CCNB10.65184303
68MAP2K70.65028614
69EEF2K0.63124276
70CDK50.63025537
71AKT30.62615878
72CDK120.61567675
73OXSR10.61489365
74MAPK130.60830845
75PRKCH0.59069253
76EPHA30.57105488
77BMPR1B0.55485585
78IRAK30.55398259
79PAK10.54783395
80CDK80.54606406
81PRKCE0.53443578
82CAMK2B0.53433322
83DDR20.52245622
84GSK3A0.51247137
85CAMK2D0.50835216
86AKT20.50598278
87MTOR0.50031291
88LIMK10.48887279
89NTRK20.48214019
90PRKG20.47836707
91DAPK30.46192993
92TEC0.45687580
93PRKG10.44717349
94STK38L0.44616482
95CAMK2A0.44582487
96PRKACA0.43991139
97MAP3K130.43893758
98YES10.43850358
99IRAK20.43534359
100TESK10.42024576
101PLK20.41421129
102PRKD10.41302642
103SIK20.40915863
104CAMK10.37911208
105MAPK70.37195764
106LATS10.36017058
107KIT0.35620721
108MKNK20.35345210
109RPS6KA30.34852562
110SGK20.34847866
111ERBB40.34677334
112SGK10.34042040
113CDK190.33399965
114NEK90.30357263
115PRKCA0.30285436
116PAK30.30282176
117CSNK1A1L0.30098251
118STK30.28402428
119MARK20.28337170
120BRSK20.27458130
121ACVR1B0.27252615
122MAPK110.27228353
123MAPK30.27091671
124MINK10.26864652
125MST1R0.26275707
126SGK2230.26099236
127SGK4940.26099236
128PLK40.25680928
129NUAK10.25420834
130RAF10.25074528
131ABL10.24819452
132TAOK20.24648306
133MAP3K100.24315455
134CDK90.24243413
135TNIK0.23811510
136MAPKAPK20.23808312
137MAPK10.23347602
138MAP3K40.23142773
139CLK10.22829162
140PRKCG0.22614871
141SGK30.22243764
142MAP3K30.22191095
143STK110.22063640
144PRKDC0.21941258
145CAMK40.21621686
146IRAK10.21415602
147CAMKK20.21219939
148RPS6KA60.19903225
149PRKACB0.19794381
150TBK10.19594762
151GRK70.19270934
152RPS6KC10.18972666
153RPS6KL10.18972666
154CDK30.17681673
155WNK30.17194094

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.28367883
2Cardiac muscle contraction_Homo sapiens_hsa042603.50007665
3Parkinsons disease_Homo sapiens_hsa050123.47036489
4Alzheimers disease_Homo sapiens_hsa050103.03935049
5Renin secretion_Homo sapiens_hsa049242.96357973
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.85519908
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.60115051
8Focal adhesion_Homo sapiens_hsa045102.60028709
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55037437
10ECM-receptor interaction_Homo sapiens_hsa045122.42835449
11Huntingtons disease_Homo sapiens_hsa050162.39802977
12Long-term potentiation_Homo sapiens_hsa047202.35453693
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.31450447
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.09724721
15Rheumatoid arthritis_Homo sapiens_hsa053232.08512127
16Dilated cardiomyopathy_Homo sapiens_hsa054142.03883336
17Graft-versus-host disease_Homo sapiens_hsa053321.90259430
18Sulfur metabolism_Homo sapiens_hsa009201.87260120
19Calcium signaling pathway_Homo sapiens_hsa040201.81710214
20Allograft rejection_Homo sapiens_hsa053301.81603921
21Starch and sucrose metabolism_Homo sapiens_hsa005001.78296470
22Nicotine addiction_Homo sapiens_hsa050331.70816150
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.65856382
24Type I diabetes mellitus_Homo sapiens_hsa049401.64894042
25Type II diabetes mellitus_Homo sapiens_hsa049301.60321107
26Arachidonic acid metabolism_Homo sapiens_hsa005901.56608195
27Circadian rhythm_Homo sapiens_hsa047101.56280940
28Amphetamine addiction_Homo sapiens_hsa050311.55364587
29cAMP signaling pathway_Homo sapiens_hsa040241.55070005
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53532013
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47328654
32Linoleic acid metabolism_Homo sapiens_hsa005911.40205091
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38965599
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37868691
35Oxytocin signaling pathway_Homo sapiens_hsa049211.37548306
36GnRH signaling pathway_Homo sapiens_hsa049121.37239799
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.33080979
38Salivary secretion_Homo sapiens_hsa049701.31122941
39Lysine degradation_Homo sapiens_hsa003101.30982657
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30169661
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.22010090
42Dopaminergic synapse_Homo sapiens_hsa047281.21094344
43Small cell lung cancer_Homo sapiens_hsa052221.18329711
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16825156
45Renal cell carcinoma_Homo sapiens_hsa052111.14127691
46Protein digestion and absorption_Homo sapiens_hsa049741.13731864
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13446082
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11685893
49Fanconi anemia pathway_Homo sapiens_hsa034601.10939114
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07759712
51Legionellosis_Homo sapiens_hsa051341.02283944
52Collecting duct acid secretion_Homo sapiens_hsa049661.01113638
53Regulation of autophagy_Homo sapiens_hsa041401.00277889
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99362518
55Malaria_Homo sapiens_hsa051440.98489105
56Platelet activation_Homo sapiens_hsa046110.96059912
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95932139
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95835247
59Long-term depression_Homo sapiens_hsa047300.95376096
60Autoimmune thyroid disease_Homo sapiens_hsa053200.95263075
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93968183
62GABAergic synapse_Homo sapiens_hsa047270.91864323
63Propanoate metabolism_Homo sapiens_hsa006400.90643958
64Dorso-ventral axis formation_Homo sapiens_hsa043200.87715697
65Morphine addiction_Homo sapiens_hsa050320.85946538
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84433350
67Mineral absorption_Homo sapiens_hsa049780.83833101
68Purine metabolism_Homo sapiens_hsa002300.83695593
69Homologous recombination_Homo sapiens_hsa034400.82352791
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.82048341
71TGF-beta signaling pathway_Homo sapiens_hsa043500.81727179
72Amoebiasis_Homo sapiens_hsa051460.80838945
73Fructose and mannose metabolism_Homo sapiens_hsa000510.79399700
74African trypanosomiasis_Homo sapiens_hsa051430.78820084
75Gap junction_Homo sapiens_hsa045400.78588401
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.77299424
77Viral myocarditis_Homo sapiens_hsa054160.76370464
78Arginine and proline metabolism_Homo sapiens_hsa003300.76060058
79Adherens junction_Homo sapiens_hsa045200.75960399
80Proteoglycans in cancer_Homo sapiens_hsa052050.74634400
81Ether lipid metabolism_Homo sapiens_hsa005650.73568645
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73269142
83Serotonergic synapse_Homo sapiens_hsa047260.72237116
84Galactose metabolism_Homo sapiens_hsa000520.71601931
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70734151
86Circadian entrainment_Homo sapiens_hsa047130.70193797
87Taste transduction_Homo sapiens_hsa047420.69349897
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69043321
89Choline metabolism in cancer_Homo sapiens_hsa052310.68579029
90Glucagon signaling pathway_Homo sapiens_hsa049220.68005247
91Colorectal cancer_Homo sapiens_hsa052100.67035480
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65959582
93Notch signaling pathway_Homo sapiens_hsa043300.65133491
94Vibrio cholerae infection_Homo sapiens_hsa051100.65079715
95Melanoma_Homo sapiens_hsa052180.64929854
96Tuberculosis_Homo sapiens_hsa051520.63967794
97Proteasome_Homo sapiens_hsa030500.63367813
98MicroRNAs in cancer_Homo sapiens_hsa052060.63297956
99Tight junction_Homo sapiens_hsa045300.62941275
100Carbon metabolism_Homo sapiens_hsa012000.62934573
101Synaptic vesicle cycle_Homo sapiens_hsa047210.62129032
102Ribosome_Homo sapiens_hsa030100.61023057
103MAPK signaling pathway_Homo sapiens_hsa040100.60523268
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60328409
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59626948
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59080126
107Pertussis_Homo sapiens_hsa051330.58500488
108Salmonella infection_Homo sapiens_hsa051320.58416953
109Phenylalanine metabolism_Homo sapiens_hsa003600.56510818
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56388854
111Leishmaniasis_Homo sapiens_hsa051400.55706531
112Gastric acid secretion_Homo sapiens_hsa049710.55377648
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54799282
114Glioma_Homo sapiens_hsa052140.53945262
115Butanoate metabolism_Homo sapiens_hsa006500.53859970
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52977034
117Phagosome_Homo sapiens_hsa041450.51118291
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49271502
119RNA polymerase_Homo sapiens_hsa030200.48959472
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48322242
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48093000
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47541097
123Asthma_Homo sapiens_hsa053100.47446676
124Insulin secretion_Homo sapiens_hsa049110.47029639
125Cocaine addiction_Homo sapiens_hsa050300.46045536
126Insulin signaling pathway_Homo sapiens_hsa049100.45589031
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45147520
128Fatty acid elongation_Homo sapiens_hsa000620.44781625
129Metabolic pathways_Homo sapiens_hsa011000.44482869
130Glutamatergic synapse_Homo sapiens_hsa047240.42374241
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42316646
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.42184409
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42142822
134FoxO signaling pathway_Homo sapiens_hsa040680.41997842
135Pathways in cancer_Homo sapiens_hsa052000.41855721
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41613828
137beta-Alanine metabolism_Homo sapiens_hsa004100.41336227
138HIF-1 signaling pathway_Homo sapiens_hsa040660.40776149
139Pancreatic secretion_Homo sapiens_hsa049720.40743667
140Inositol phosphate metabolism_Homo sapiens_hsa005620.40111459
141Protein export_Homo sapiens_hsa030600.37999950
142Non-homologous end-joining_Homo sapiens_hsa034500.37534097
143Sulfur relay system_Homo sapiens_hsa041220.37224406
144ErbB signaling pathway_Homo sapiens_hsa040120.36190351
145Pancreatic cancer_Homo sapiens_hsa052120.34440023
146Cholinergic synapse_Homo sapiens_hsa047250.33813869
147Glycerolipid metabolism_Homo sapiens_hsa005610.33744105
148Hematopoietic cell lineage_Homo sapiens_hsa046400.33595442
149Wnt signaling pathway_Homo sapiens_hsa043100.33339965
150Hippo signaling pathway_Homo sapiens_hsa043900.31963556
151Pyruvate metabolism_Homo sapiens_hsa006200.30137895
152Staphylococcus aureus infection_Homo sapiens_hsa051500.29887984
153Endometrial cancer_Homo sapiens_hsa052130.29151222
154Ras signaling pathway_Homo sapiens_hsa040140.28789593
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28725250
156Leukocyte transendothelial migration_Homo sapiens_hsa046700.28717463
157mTOR signaling pathway_Homo sapiens_hsa041500.27282617
158TNF signaling pathway_Homo sapiens_hsa046680.26704553
159Estrogen signaling pathway_Homo sapiens_hsa049150.26119351
160Axon guidance_Homo sapiens_hsa043600.25858406
161Olfactory transduction_Homo sapiens_hsa047400.25715349
162Ovarian steroidogenesis_Homo sapiens_hsa049130.24626644
163Chronic myeloid leukemia_Homo sapiens_hsa052200.24087239
164Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21645479
165One carbon pool by folate_Homo sapiens_hsa006700.21640372
166Cell cycle_Homo sapiens_hsa041100.20504032

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