OTOA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1auditory receptor cell differentiation (GO:0042491)7.96296952
2inner ear receptor cell differentiation (GO:0060113)6.41176067
3mechanoreceptor differentiation (GO:0042490)5.10186809
4regulation of cardioblast proliferation (GO:0003264)4.80051740
5regulation of secondary heart field cardioblast proliferation (GO:0003266)4.80051740
6hair cell differentiation (GO:0035315)4.51433789
7cartilage condensation (GO:0001502)4.45219535
8cell aggregation (GO:0098743)4.45219535
9tryptophan catabolic process (GO:0006569)4.44707681
10indole-containing compound catabolic process (GO:0042436)4.44707681
11indolalkylamine catabolic process (GO:0046218)4.44707681
12diterpenoid biosynthetic process (GO:0016102)4.41627385
13righting reflex (GO:0060013)4.38943546
14response to pheromone (GO:0019236)4.14778359
15water-soluble vitamin biosynthetic process (GO:0042364)4.01982958
16detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.94029563
17* sensory perception of sound (GO:0007605)3.93568217
18kynurenine metabolic process (GO:0070189)3.92995792
19polyketide metabolic process (GO:0030638)3.92255414
20doxorubicin metabolic process (GO:0044598)3.92255414
21daunorubicin metabolic process (GO:0044597)3.92255414
22* sensory perception of mechanical stimulus (GO:0050954)3.89883554
23indolalkylamine metabolic process (GO:0006586)3.86892483
24behavioral response to nicotine (GO:0035095)3.86075366
25positive regulation of cellular amide metabolic process (GO:0034250)3.76525903
26type B pancreatic cell development (GO:0003323)3.76361184
27fucose catabolic process (GO:0019317)3.76353004
28L-fucose metabolic process (GO:0042354)3.76353004
29L-fucose catabolic process (GO:0042355)3.76353004
30reflex (GO:0060004)3.68395187
31piRNA metabolic process (GO:0034587)3.66974222
32urinary tract smooth muscle contraction (GO:0014848)3.65804041
33platelet dense granule organization (GO:0060155)3.62884458
34face development (GO:0060324)3.60702132
35tryptophan metabolic process (GO:0006568)3.58282777
36negative regulation of telomere maintenance (GO:0032205)3.56923297
37mesenchyme morphogenesis (GO:0072132)3.51537913
38pentose metabolic process (GO:0019321)3.43995588
39inner ear morphogenesis (GO:0042472)3.41510368
40DNA deamination (GO:0045006)3.34872719
41regulation of somitogenesis (GO:0014807)3.34630729
42negative regulation of mast cell activation (GO:0033004)3.33882938
43cellular biogenic amine catabolic process (GO:0042402)3.32226676
44amine catabolic process (GO:0009310)3.32226676
45negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.32167837
46mesenchymal cell differentiation (GO:0048762)3.30739407
47myoblast migration (GO:0051451)3.26333441
48cellular ketone body metabolic process (GO:0046950)3.26278749
49detection of light stimulus involved in sensory perception (GO:0050962)3.24866057
50detection of light stimulus involved in visual perception (GO:0050908)3.24866057
51embryonic eye morphogenesis (GO:0048048)3.23720561
52glandular epithelial cell development (GO:0002068)3.22086895
53multicellular organism reproduction (GO:0032504)3.19628603
54regulation of non-canonical Wnt signaling pathway (GO:2000050)3.18360503
55dorsal/ventral axis specification (GO:0009950)3.12571178
56pharyngeal system development (GO:0060037)3.12371797
57positive regulation of hormone biosynthetic process (GO:0046886)3.10636177
58DNA methylation involved in gamete generation (GO:0043046)3.09092996
59synapsis (GO:0007129)3.07506315
60signal peptide processing (GO:0006465)3.07372602
61regulation of cilium movement (GO:0003352)3.05945303
62ketone body metabolic process (GO:1902224)3.03115794
63axoneme assembly (GO:0035082)3.02434606
64regulation of rhodopsin mediated signaling pathway (GO:0022400)3.02207943
65neural tube formation (GO:0001841)3.01692142
66glycoprotein catabolic process (GO:0006516)3.01290385
67female gonad development (GO:0008585)3.01211697
68regulation of meiosis I (GO:0060631)3.00962989
69cochlea morphogenesis (GO:0090103)3.00602344
70detection of molecule of bacterial origin (GO:0032490)2.99830472
71glycerophospholipid catabolic process (GO:0046475)2.99727135
72regulation of extracellular matrix disassembly (GO:0010715)2.99601946
73epithelial cilium movement (GO:0003351)2.99536605
74endocardial cushion morphogenesis (GO:0003203)2.98195316
75NAD biosynthetic process (GO:0009435)2.96383600
76indole-containing compound metabolic process (GO:0042430)2.95709587
77DNA double-strand break processing (GO:0000729)2.95537856
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94964636
79positive regulation of prostaglandin secretion (GO:0032308)2.94183381
80embryonic camera-type eye morphogenesis (GO:0048596)2.91515624
81kidney morphogenesis (GO:0060993)2.90421898
82synaptic transmission, cholinergic (GO:0007271)2.89552633
83regulation of activation of Janus kinase activity (GO:0010533)2.89192842
84photoreceptor cell maintenance (GO:0045494)2.89181360
85rhodopsin mediated signaling pathway (GO:0016056)2.88965379
86regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.86719059
87positive regulation of endothelial cell differentiation (GO:0045603)2.82810574
88cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.81751141
89male meiosis (GO:0007140)2.80160057
90protein complex biogenesis (GO:0070271)2.79254811
91mitochondrial respiratory chain complex I assembly (GO:0032981)2.77080801
92NADH dehydrogenase complex assembly (GO:0010257)2.77080801
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.77080801
94respiratory chain complex IV assembly (GO:0008535)2.76849176
95chondrocyte differentiation (GO:0002062)2.76061952
96inner ear receptor stereocilium organization (GO:0060122)2.75168683
97mesenchymal-epithelial cell signaling (GO:0060638)2.72636676
98negative regulation of homotypic cell-cell adhesion (GO:0034111)2.71674674
99sperm motility (GO:0030317)2.71074680
100terpenoid biosynthetic process (GO:0016114)2.70892496
101retinal cone cell development (GO:0046549)2.70737766
102mesenchymal cell differentiation involved in renal system development (GO:2001012)2.69604374
103mesenchymal cell differentiation involved in kidney development (GO:0072161)2.69604374
104negative regulation of osteoblast proliferation (GO:0033689)2.68790816
105gamma-aminobutyric acid transport (GO:0015812)2.68383229
106negative regulation of systemic arterial blood pressure (GO:0003085)2.68256758
107generation of neurons (GO:0048699)2.68225357
108auditory receptor cell stereocilium organization (GO:0060088)2.67836789
109adaptation of signaling pathway (GO:0023058)2.67493248
110regulation of nuclear cell cycle DNA replication (GO:0033262)2.66352179
111regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.66214195
112regulation of telomere maintenance (GO:0032204)2.65207974
113replication fork processing (GO:0031297)2.63790867
114behavioral response to pain (GO:0048266)2.63149939
115regulation of mesenchymal cell apoptotic process (GO:2001053)2.62350144
116cilium morphogenesis (GO:0060271)2.61475634
117cytochrome complex assembly (GO:0017004)2.60796545
118behavioral response to ethanol (GO:0048149)2.59562805
119positive regulation of defense response to virus by host (GO:0002230)2.58965298
120protein localization to cilium (GO:0061512)2.58656768
121regulation of lymphocyte chemotaxis (GO:1901623)2.57647905
122positive regulation of interleukin-1 beta secretion (GO:0050718)2.57608417
123male meiosis I (GO:0007141)2.57518102
124cell wall macromolecule metabolic process (GO:0044036)2.57404304
125benzene-containing compound metabolic process (GO:0042537)2.57039809
126regulation of chemokine-mediated signaling pathway (GO:0070099)2.57001713
127regulation of organ formation (GO:0003156)2.56818330
128aromatic amino acid family catabolic process (GO:0009074)2.56792416
129positive regulation of DNA-dependent DNA replication (GO:2000105)2.56732976
130centriole replication (GO:0007099)2.56292177
131dopamine transport (GO:0015872)2.56279462
132negative regulation of keratinocyte proliferation (GO:0010839)2.55072465
133histone H3-K36 demethylation (GO:0070544)2.54784844
134protein polyglutamylation (GO:0018095)2.54652371
135mitochondrial respiratory chain complex assembly (GO:0033108)2.53646679
136metanephric mesenchyme development (GO:0072075)2.53297835
137detection of mechanical stimulus involved in sensory perception (GO:0050974)2.53087560
138positive regulation of fatty acid transport (GO:2000193)2.52111789
139prostate gland growth (GO:0060736)2.51533369
140recombinational repair (GO:0000725)2.50838736
141photoreceptor cell development (GO:0042461)2.50585155
142retinal ganglion cell axon guidance (GO:0031290)2.50319689
143double-strand break repair via homologous recombination (GO:0000724)2.49644238
144cartilage development (GO:0051216)2.48227408
145interferon-gamma production (GO:0032609)2.47176054
146regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.47114125
147regulation of microtubule-based movement (GO:0060632)2.45908686
148L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.44487679
149vitamin biosynthetic process (GO:0009110)2.43146136
150energy homeostasis (GO:0097009)2.42753502
151epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.41022892
152regulation of heart morphogenesis (GO:2000826)2.40426108
153negative regulation of reactive oxygen species metabolic process (GO:2000378)2.39930002
154cranial nerve development (GO:0021545)2.39071830
155cilium or flagellum-dependent cell motility (GO:0001539)2.38848471
156regulation of alkaline phosphatase activity (GO:0010692)2.38719166
157superoxide anion generation (GO:0042554)2.38426941
158negative regulation of transcription regulatory region DNA binding (GO:2000678)2.38140774
159negative regulation of interleukin-1 beta production (GO:0032691)2.37655628
160positive regulation of T cell apoptotic process (GO:0070234)2.36876395
161replicative senescence (GO:0090399)2.36859241
162transepithelial transport (GO:0070633)2.36749538
163RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.36733362
164cilium movement (GO:0003341)2.36427393
165somite development (GO:0061053)2.35649049
166regulation of T cell chemotaxis (GO:0010819)2.35222137
167positive regulation of T cell chemotaxis (GO:0010820)2.35222137
168cellular response to ATP (GO:0071318)2.35119360
169regulation of prostaglandin secretion (GO:0032306)2.34557146
170regulation of interleukin-1 beta secretion (GO:0050706)2.34473856
171sphingoid metabolic process (GO:0046519)2.34416028
172positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.34023807
173ganglion development (GO:0061548)2.33721243
174eye photoreceptor cell development (GO:0042462)2.33106196
175adenosine metabolic process (GO:0046085)2.32655824
176alanine transport (GO:0032328)2.31993419
177cell wall macromolecule catabolic process (GO:0016998)2.31707086
178regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.31629997
179cranial nerve morphogenesis (GO:0021602)2.29877784
180positive regulation of interleukin-1 secretion (GO:0050716)2.29490034
181oxidative demethylation (GO:0070989)2.29053401
182negative regulation of cytosolic calcium ion concentration (GO:0051481)2.29034741
183regulation of keratinocyte proliferation (GO:0010837)2.28877344
184protein K6-linked ubiquitination (GO:0085020)2.28865658
185aorta morphogenesis (GO:0035909)2.28436011
186columnar/cuboidal epithelial cell development (GO:0002066)2.28399949
187dentate gyrus development (GO:0021542)2.28165500
188epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.27349026
189hair follicle development (GO:0001942)2.26253078
190positive regulation of heat generation (GO:0031652)2.25261393
191detection of mechanical stimulus (GO:0050982)2.24722591
192positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.23856222
193presynaptic membrane organization (GO:0097090)2.23633947
194mesonephros development (GO:0001823)2.22574090
195regulation of transforming growth factor beta2 production (GO:0032909)2.22328385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.04453969
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.89716949
3VDR_22108803_ChIP-Seq_LS180_Human3.15594980
4GBX2_23144817_ChIP-Seq_PC3_Human3.02619525
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.63525751
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.58819313
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.49410898
8IGF1R_20145208_ChIP-Seq_DFB_Human2.40461910
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.34049212
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30593775
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.27769755
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.19010096
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08504622
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01573687
15SUZ12_27294783_Chip-Seq_NPCs_Mouse1.97500947
16PCGF2_27294783_Chip-Seq_NPCs_Mouse1.96132848
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.94757429
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94016379
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92686372
20POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.89470862
21TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89470862
22P300_19829295_ChIP-Seq_ESCs_Human1.86292982
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.85646274
24ER_23166858_ChIP-Seq_MCF-7_Human1.83294530
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80270279
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79062614
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.78895657
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78060915
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78001739
30NANOG_18555785_Chip-Seq_ESCs_Mouse1.77733051
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77435947
32P53_22387025_ChIP-Seq_ESCs_Mouse1.77103397
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.76590848
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76206249
35E2F1_18555785_Chip-Seq_ESCs_Mouse1.75034934
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.74115945
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74085395
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.74023090
39EZH2_22144423_ChIP-Seq_EOC_Human1.70820639
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69123760
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.67646675
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.66883674
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65936192
44SUZ12_18555785_Chip-Seq_ESCs_Mouse1.63126540
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62908920
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62774621
47STAT3_18555785_Chip-Seq_ESCs_Mouse1.60632264
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.59039753
49BCAT_22108803_ChIP-Seq_LS180_Human1.58727511
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58634989
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.57458971
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56327874
53CBP_20019798_ChIP-Seq_JUKART_Human1.56327874
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55154499
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54468632
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53673750
57SMAD4_21799915_ChIP-Seq_A2780_Human1.53128834
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51334504
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51066713
60AR_25329375_ChIP-Seq_VCAP_Human1.51028317
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.50893602
62CMYC_18555785_Chip-Seq_ESCs_Mouse1.50702895
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50365848
64NANOG_19829295_ChIP-Seq_ESCs_Human1.49476253
65SOX2_19829295_ChIP-Seq_ESCs_Human1.49476253
66TP53_18474530_ChIP-ChIP_U2OS_Human1.49317898
67TP53_22573176_ChIP-Seq_HFKS_Human1.47712572
68TAF15_26573619_Chip-Seq_HEK293_Human1.47026549
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46971357
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46426903
71FUS_26573619_Chip-Seq_HEK293_Human1.45245027
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.45156324
73NMYC_18555785_Chip-Seq_ESCs_Mouse1.45103661
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.44725995
75P300_18555785_Chip-Seq_ESCs_Mouse1.43136149
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40839006
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40053544
78SOX2_18555785_Chip-Seq_ESCs_Mouse1.39999619
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39506404
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38047439
81ZFX_18555785_Chip-Seq_ESCs_Mouse1.37242755
82TCF4_23295773_ChIP-Seq_U87_Human1.37121131
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.36136034
84EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.36064055
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35891436
86OCT4_18555785_Chip-Seq_ESCs_Mouse1.35777497
87GATA1_22025678_ChIP-Seq_K562_Human1.35670777
88AHR_22903824_ChIP-Seq_MCF-7_Human1.35314893
89EWS_26573619_Chip-Seq_HEK293_Human1.35280340
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34535803
91GABP_17652178_ChIP-ChIP_JURKAT_Human1.34318289
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.33412603
93RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32084865
94EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32084865
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31118103
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30988725
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.30762661
98RUNX1_27457419_Chip-Seq_LIVER_Mouse1.30734261
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30012046
100PU1_27457419_Chip-Seq_LIVER_Mouse1.30008660
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29864781
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29852038
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29808769
104TCF4_22108803_ChIP-Seq_LS180_Human1.29437364
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28412039
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28148008
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.28148008
108* TAL1_26923725_Chip-Seq_HPCs_Mouse1.27905982
109KLF4_18555785_Chip-Seq_ESCs_Mouse1.27807970
110ESR1_21235772_ChIP-Seq_MCF-7_Human1.27434482
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26914758
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26866430
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.26487270
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26262398
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25758551
116CBX2_27304074_Chip-Seq_ESCs_Mouse1.24678375
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23866555
118* STAT3_23295773_ChIP-Seq_U87_Human1.23324363
119IRF8_22096565_ChIP-ChIP_GC-B_Human1.22293445
120SALL1_21062744_ChIP-ChIP_HESCs_Human1.21072290
121IRF1_19129219_ChIP-ChIP_H3396_Human1.20887961
122OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19753498
123EP300_21415370_ChIP-Seq_HL-1_Mouse1.19743714
124FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19539279
125CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19476853
126EST1_17652178_ChIP-ChIP_JURKAT_Human1.19301534
127AR_20517297_ChIP-Seq_VCAP_Human1.19278365
128VDR_24787735_ChIP-Seq_THP-1_Human1.19085777
129SMAD1_18555785_Chip-Seq_ESCs_Mouse1.19079241
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.18906423
131KDM2B_26808549_Chip-Seq_REH_Human1.18784222
132RUNX2_22187159_ChIP-Seq_PCA_Human1.18234601
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17930292
134ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17336436
135* NCOR_22424771_ChIP-Seq_293T_Human1.17308662
136* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17016430
137SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16952506
138NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14892102
139EZH2_27294783_Chip-Seq_ESCs_Mouse1.14675231
140CTCF_18555785_Chip-Seq_ESCs_Mouse1.14570096
141FLI1_21867929_ChIP-Seq_TH2_Mouse1.14511285
142GATA3_21878914_ChIP-Seq_MCF-7_Human1.13058461
143IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12678595
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12370417
145MYC_18940864_ChIP-ChIP_HL60_Human1.11307995
146* CDX2_22108803_ChIP-Seq_LS180_Human1.10650419
147RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09812828
148LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08294800
149* HOXB7_26014856_ChIP-Seq_BT474_Human1.06433503
150PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06089618
151GATA3_26560356_Chip-Seq_TH2_Human1.04406016
152* REST_21632747_ChIP-Seq_MESCs_Mouse1.00052987
153FOXH1_21741376_ChIP-Seq_EPCs_Human0.98813105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003879_abnormal_hair_cell8.04258778
2MP0001485_abnormal_pinna_reflex4.95331358
3MP0005377_hearing/vestibular/ear_phenot4.94574106
4MP0003878_abnormal_ear_physiology4.94574106
5MP0000026_abnormal_inner_ear4.01571226
6MP0001963_abnormal_hearing_physiology3.80676641
7MP0005248_abnormal_Harderian_gland3.77621892
8MP0003195_calcinosis3.20433228
9MP0002254_reproductive_system_inflammat3.03177227
10MP0002837_dystrophic_cardiac_calcinosis2.96655088
11MP0003646_muscle_fatigue2.86245438
12MP0008877_abnormal_DNA_methylation2.79194896
13MP0001346_abnormal_lacrimal_gland2.68086439
14MP0000566_synostosis2.51597772
15MP0005551_abnormal_eye_electrophysiolog2.46764828
16MP0003941_abnormal_skin_development2.10466531
17MP0001501_abnormal_sleep_pattern2.04527755
18MP0002277_abnormal_respiratory_mucosa2.00489121
19MP0005410_abnormal_fertilization1.89665016
20MP0005646_abnormal_pituitary_gland1.86880723
21MP0004742_abnormal_vestibular_system1.81780314
22MP0005253_abnormal_eye_physiology1.81387951
23MP0002938_white_spotting1.77629926
24MP0002102_abnormal_ear_morphology1.73222723
25MP0009046_muscle_twitch1.70926562
26MP0004134_abnormal_chest_morphology1.70874321
27MP0009745_abnormal_behavioral_response1.64404303
28MP0008875_abnormal_xenobiotic_pharmacok1.64004640
29MP0006082_CNS_inflammation1.62055523
30MP0006072_abnormal_retinal_apoptosis1.60436402
31MP0001188_hyperpigmentation1.58808851
32MP0003787_abnormal_imprinting1.55813147
33MP0009764_decreased_sensitivity_to1.54407760
34MP0008872_abnormal_physiological_respon1.53323282
35MP0001502_abnormal_circadian_rhythm1.48099086
36MP0000049_abnormal_middle_ear1.46697738
37MP0000613_abnormal_salivary_gland1.45323989
38MP0010030_abnormal_orbit_morphology1.44636770
39MP0003942_abnormal_urinary_system1.44395943
40MP0005171_absent_coat_pigmentation1.44376108
41MP0003011_delayed_dark_adaptation1.44215847
42MP0001986_abnormal_taste_sensitivity1.42212420
43MP0001486_abnormal_startle_reflex1.40793149
44MP0002933_joint_inflammation1.39408446
45MP0006292_abnormal_olfactory_placode1.38174004
46MP0002163_abnormal_gland_morphology1.37814642
47MP0001764_abnormal_homeostasis1.37440105
48MP0005167_abnormal_blood-brain_barrier1.37389854
49MP0000569_abnormal_digit_pigmentation1.36708354
50MP0004043_abnormal_pH_regulation1.36030604
51MP0002233_abnormal_nose_morphology1.35645183
52MP0000678_abnormal_parathyroid_gland1.33416728
53MP0001270_distended_abdomen1.32737844
54MP0005508_abnormal_skeleton_morphology1.29996872
55MP0002139_abnormal_hepatobiliary_system1.29243142
56MP0004133_heterotaxia1.28174452
57MP0000516_abnormal_urinary_system1.27938169
58MP0005367_renal/urinary_system_phenotyp1.27938169
59MP0005503_abnormal_tendon_morphology1.27421345
60MP0004147_increased_porphyrin_level1.26736573
61MP0002249_abnormal_larynx_morphology1.25853010
62MP0005647_abnormal_sex_gland1.23067792
63MP0002638_abnormal_pupillary_reflex1.22635487
64MP0000163_abnormal_cartilage_morphology1.22230861
65MP0000372_irregular_coat_pigmentation1.22214970
66MP0005379_endocrine/exocrine_gland_phen1.22043381
67MP0003880_abnormal_central_pattern1.21280030
68MP0009697_abnormal_copulation1.21138685
69MP0002736_abnormal_nociception_after1.18954301
70MP0002064_seizures1.17868809
71MP0005075_abnormal_melanosome_morpholog1.14635562
72MP0009250_abnormal_appendicular_skeleto1.13653091
73MP0003718_maternal_effect1.13089633
74MP0005645_abnormal_hypothalamus_physiol1.12720002
75MP0000230_abnormal_systemic_arterial1.08951978
76MP0002116_abnormal_craniofacial_bone1.08625234
77MP0000762_abnormal_tongue_morphology1.08438678
78MP0005390_skeleton_phenotype1.05098907
79MP0001919_abnormal_reproductive_system1.04107591
80MP0001970_abnormal_pain_threshold1.03635224
81MP0003136_yellow_coat_color1.03084329
82MP0002733_abnormal_thermal_nociception1.00190864
83MP0000681_abnormal_thyroid_gland0.98715544
84MP0003806_abnormal_nucleotide_metabolis0.98664375
85MP0004142_abnormal_muscle_tone0.98472589
86MP0005389_reproductive_system_phenotype0.98281780
87MP0010386_abnormal_urinary_bladder0.96621930
88MP0002653_abnormal_ependyma_morphology0.96327667
89MP0005195_abnormal_posterior_eye0.95762026
90MP0008789_abnormal_olfactory_epithelium0.95600901
91MP0002572_abnormal_emotion/affect_behav0.94968462
92MP0003698_abnormal_male_reproductive0.94614706
93MP0001929_abnormal_gametogenesis0.94051187
94MP0002282_abnormal_trachea_morphology0.93740106
95MP0002115_abnormal_skeleton_extremities0.93372869
96MP0002557_abnormal_social/conspecific_i0.93085188
97MP0005387_immune_system_phenotype0.92640339
98MP0001790_abnormal_immune_system0.92640339
99MP0004885_abnormal_endolymph0.92582641
100MP0002109_abnormal_limb_morphology0.92184275
101MP0001324_abnormal_eye_pigmentation0.91628541
102MP0002229_neurodegeneration0.90516449
103MP0002090_abnormal_vision0.90239882
104MP0002098_abnormal_vibrissa_morphology0.90227202
105MP0002132_abnormal_respiratory_system0.89218534
106MP0006054_spinal_hemorrhage0.88910128
107MP0001835_abnormal_antigen_presentation0.88595546
108MP0000647_abnormal_sebaceous_gland0.88450389
109MP0002113_abnormal_skeleton_development0.88105181
110MP0000534_abnormal_ureter_morphology0.87937797
111MP0004924_abnormal_behavior0.87907920
112MP0005386_behavior/neurological_phenoty0.87907920
113MP0000383_abnormal_hair_follicle0.86945825
114MP0002932_abnormal_joint_morphology0.86869726
115MP0002735_abnormal_chemical_nociception0.85437468
116MP0000015_abnormal_ear_pigmentation0.84132227
117MP0002177_abnormal_outer_ear0.83611637
118MP0006276_abnormal_autonomic_nervous0.83543637
119MP0000631_abnormal_neuroendocrine_gland0.83386139
120MP0003172_abnormal_lysosome_physiology0.83345457
121MP0006036_abnormal_mitochondrial_physio0.83185832
122MP0002089_abnormal_postnatal_growth/wei0.82671097
123MP0001533_abnormal_skeleton_physiology0.82210738
124MP0003938_abnormal_ear_development0.81382301
125MP0000579_abnormal_nail_morphology0.80374781
126MP0004215_abnormal_myocardial_fiber0.80290035
127MP0004145_abnormal_muscle_electrophysio0.80198785
128MP0001286_abnormal_eye_development0.79976755
129MP0000538_abnormal_urinary_bladder0.79484057
130MP0001984_abnormal_olfaction0.79305791
131MP0009785_altered_susceptibility_to0.78064908
132MP0004782_abnormal_surfactant_physiolog0.77421496
133MP0003137_abnormal_impulse_conducting0.77393074
134MP0005310_abnormal_salivary_gland0.76826251
135MP0004264_abnormal_extraembryonic_tissu0.76702466
136MP0010678_abnormal_skin_adnexa0.75775830
137MP0002693_abnormal_pancreas_physiology0.75632069
138MP0005085_abnormal_gallbladder_physiolo0.75629468
139MP0005671_abnormal_response_to0.75164190
140MP0002734_abnormal_mechanical_nocicepti0.73972870
141MP0009780_abnormal_chondrocyte_physiolo0.73550284
142MP0002877_abnormal_melanocyte_morpholog0.72805272
143MP0003755_abnormal_palate_morphology0.72486174
144MP0002148_abnormal_hypersensitivity_rea0.71876782
145MP0001968_abnormal_touch/_nociception0.71018313
146MP0001293_anophthalmia0.69202816
147MP0002396_abnormal_hematopoietic_system0.68239266
148MP0003121_genomic_imprinting0.67859427
149MP0008004_abnormal_stomach_pH0.66998297
150MP0002998_abnormal_bone_remodeling0.64963561
151MP0002095_abnormal_skin_pigmentation0.64395298
152MP0001299_abnormal_eye_distance/0.63987183
153MP0005257_abnormal_intraocular_pressure0.62869523
154MP0002876_abnormal_thyroid_physiology0.61737231
155MP0002138_abnormal_hepatobiliary_system0.61136747
156MP0002752_abnormal_somatic_nervous0.60184635
157MP0002751_abnormal_autonomic_nervous0.59274611
158MP0005174_abnormal_tail_pigmentation0.58255347
159MP0002272_abnormal_nervous_system0.58028029
160MP0000427_abnormal_hair_cycle0.57502661
161MP0000465_gastrointestinal_hemorrhage0.54394721

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)8.94433764
2Vitreoretinal degeneration (HP:0000655)6.70082995
3Irregular epiphyses (HP:0010582)5.72809692
4Severe Myopia (HP:0011003)4.88966284
5Hypoplastic ischia (HP:0003175)4.83934166
6Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.68993265
7Abnormality of the ischium (HP:0003174)4.33785628
8Mild short stature (HP:0003502)4.31054818
9Pancreatic cysts (HP:0001737)4.30826880
10Congenital stationary night blindness (HP:0007642)3.89360952
11Congenital sensorineural hearing impairment (HP:0008527)3.77469631
12Pancreatic fibrosis (HP:0100732)3.66358235
13Mixed hearing impairment (HP:0000410)3.64800329
14Genu varum (HP:0002970)3.63421694
15Absent epiphyses (HP:0010577)3.58059757
16Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.58059757
17Abolished electroretinogram (ERG) (HP:0000550)3.56172472
18Small epiphyses (HP:0010585)3.50346797
19Attenuation of retinal blood vessels (HP:0007843)3.47222407
20Lip pit (HP:0100267)3.46022506
21Flattened epiphyses (HP:0003071)3.35944804
22Nephronophthisis (HP:0000090)3.33885097
23Aplasia/Hypoplasia of the fovea (HP:0008060)3.29733933
24Hypoplasia of the fovea (HP:0007750)3.29733933
25Abnormality of the pubic bones (HP:0003172)3.22965523
26Increased neuronal autofluorescent lipopigment (HP:0002074)3.05571375
27Abnormality of the renal medulla (HP:0100957)3.00561247
28Abnormality of the renal cortex (HP:0011035)2.97410763
29Pendular nystagmus (HP:0012043)2.92580584
30Enlarged epiphyses (HP:0010580)2.89448604
31Bell-shaped thorax (HP:0001591)2.86258365
32Increased cerebral lipofuscin (HP:0011813)2.84269153
33Hyperventilation (HP:0002883)2.78507218
34Abnormal rod and cone electroretinograms (HP:0008323)2.75093791
35Abnormality of the fovea (HP:0000493)2.74919668
36Type II lissencephaly (HP:0007260)2.68389788
37Gaze-evoked nystagmus (HP:0000640)2.65144763
38Delayed epiphyseal ossification (HP:0002663)2.64211800
39Abnormality of the vitreous humor (HP:0004327)2.62254627
40Abnormal drinking behavior (HP:0030082)2.61713218
41Polydipsia (HP:0001959)2.61713218
42Abnormality of liposaccharide metabolism (HP:0010968)2.59770278
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.59770278
44Abnormality of glycolipid metabolism (HP:0010969)2.59770278
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58958848
46Abnormality of alanine metabolism (HP:0010916)2.58958848
47Hyperalaninemia (HP:0003348)2.58958848
48Vacuolated lymphocytes (HP:0001922)2.58672508
49Optic neuritis (HP:0100653)2.55624733
50Retrobulbar optic neuritis (HP:0100654)2.55624733
51Osteoarthritis (HP:0002758)2.55509462
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54541001
53Micromelia (HP:0002983)2.53832009
54Abnormality of the vertebral endplates (HP:0005106)2.53758663
55Abnormality of incisor morphology (HP:0011063)2.53425020
56Tubular atrophy (HP:0000092)2.50073411
57Cystic liver disease (HP:0006706)2.48047622
58Unilateral renal agenesis (HP:0000122)2.46849306
59Renal dysplasia (HP:0000110)2.46509178
60Medial flaring of the eyebrow (HP:0010747)2.42635785
61Chronic hepatic failure (HP:0100626)2.42606902
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.35720778
63Flat capital femoral epiphysis (HP:0003370)2.33878396
64Decreased central vision (HP:0007663)2.31927298
65Abnormality of the femoral head (HP:0003368)2.29753751
66Vertebral clefting (HP:0008428)2.29355639
67Morphological abnormality of the middle ear (HP:0008609)2.28862013
68Furrowed tongue (HP:0000221)2.28182555
69Abnormality of the epiphysis of the femoral head (HP:0010574)2.27047893
70Stomatitis (HP:0010280)2.25454466
71Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.25167278
72Abnormality of femoral epiphyses (HP:0006499)2.25167278
73Hematochezia (HP:0002573)2.24492021
74Sclerocornea (HP:0000647)2.21983199
75Bony spicule pigmentary retinopathy (HP:0007737)2.21841472
763-Methylglutaconic aciduria (HP:0003535)2.20992689
77Abnormal biliary tract physiology (HP:0012439)2.19051565
78Bile duct proliferation (HP:0001408)2.19051565
79Aplasia/Hypoplasia of the macula (HP:0008059)2.17550667
80Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17049150
81Recurrent pneumonia (HP:0006532)2.16820093
82Metaphyseal dysplasia (HP:0100255)2.16754389
83Increased CSF lactate (HP:0002490)2.16343491
84Keratoconjunctivitis sicca (HP:0001097)2.15723488
85Renal cortical cysts (HP:0000803)2.15603610
86Recurrent corneal erosions (HP:0000495)2.14849014
87Decreased circulating renin level (HP:0003351)2.13725051
88Increased corneal curvature (HP:0100692)2.13499163
89Keratoconus (HP:0000563)2.13499163
90Platyspondyly (HP:0000926)2.12752808
91Sprengel anomaly (HP:0000912)2.12510608
92Inability to walk (HP:0002540)2.11687037
93Large for gestational age (HP:0001520)2.10841050
94Congenital hepatic fibrosis (HP:0002612)2.09611851
95Anencephaly (HP:0002323)2.08593478
96Chromsome breakage (HP:0040012)2.07719060
97Abnormality of the intervertebral disk (HP:0005108)2.07107147
98Optic nerve hypoplasia (HP:0000609)2.05221088
99Abnormal hair whorl (HP:0010721)2.04454232
100Cerebellar dysplasia (HP:0007033)2.04068999
101Aplasia/Hypoplasia of the tongue (HP:0010295)2.03723333
102Polyuria (HP:0000103)2.03244448
103Abnormality of the renal collecting system (HP:0004742)2.02567211
104Absent eyelashes (HP:0000561)2.02312555
105Chorioretinal atrophy (HP:0000533)2.02303768
106Hemiparesis (HP:0001269)1.99844847
107Exostoses (HP:0100777)1.99391702
108Absent speech (HP:0001344)1.98295490
109Osteomalacia (HP:0002749)1.96769146
110Progressive inability to walk (HP:0002505)1.96043389
111Keratoconjunctivitis (HP:0001096)1.95223634
112Optic disc pallor (HP:0000543)1.95209518
113Male pseudohermaphroditism (HP:0000037)1.93746077
114Genu valgum (HP:0002857)1.93514597
115Synostosis of carpal bones (HP:0005048)1.92755512
116Molar tooth sign on MRI (HP:0002419)1.91947740
117Abnormality of midbrain morphology (HP:0002418)1.91947740
118Cervical subluxation (HP:0003308)1.91162009
119Progressive macrocephaly (HP:0004481)1.91120433
120Mitochondrial inheritance (HP:0001427)1.90650585
121Congenital, generalized hypertrichosis (HP:0004540)1.90497396
122Methylmalonic acidemia (HP:0002912)1.90456671
123Acute necrotizing encephalopathy (HP:0006965)1.90434381
124Hip dysplasia (HP:0001385)1.89954191
125Intestinal atresia (HP:0011100)1.89853939
126Inappropriate behavior (HP:0000719)1.89698163
127Clumsiness (HP:0002312)1.88985851
128Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87489311
129Orchitis (HP:0100796)1.87153795
130Agnosia (HP:0010524)1.86717761
131Absent eyebrow (HP:0002223)1.86660081
132Dynein arm defect of respiratory motile cilia (HP:0012255)1.86498773
133Absent/shortened dynein arms (HP:0200106)1.86498773
134Methylmalonic aciduria (HP:0012120)1.86102998
135Morphological abnormality of the inner ear (HP:0011390)1.84860138
136Abnormality of macular pigmentation (HP:0008002)1.84460718
137Astigmatism (HP:0000483)1.83851032
138Severe visual impairment (HP:0001141)1.82834920
139Lissencephaly (HP:0001339)1.82557824
140Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82410982
141Focal seizures (HP:0007359)1.81814477
142Gait imbalance (HP:0002141)1.80804708
143Dialeptic seizures (HP:0011146)1.79275791
144Congenital primary aphakia (HP:0007707)1.78598474
145Hypoplastic ilia (HP:0000946)1.78334227
146Submucous cleft hard palate (HP:0000176)1.77339273
147Alveolar cell carcinoma (HP:0006519)1.77117598
148Volvulus (HP:0002580)1.76973075
149Retinal atrophy (HP:0001105)1.76957221
150White forelock (HP:0002211)1.76339286
151Disinhibition (HP:0000734)1.76071700
152Generalized aminoaciduria (HP:0002909)1.75625841
153Aplasia/Hypoplasia affecting the retina (HP:0008061)1.75573613
154Ketosis (HP:0001946)1.75063257
155Ketoacidosis (HP:0001993)1.74514444
156Mesomelia (HP:0003027)1.73761095
157Midline defect of the nose (HP:0004122)1.73556426
158Acute encephalopathy (HP:0006846)1.73123052
159Absent frontal sinuses (HP:0002688)1.72461897
160Febrile seizures (HP:0002373)1.71798933
161Progressive cerebellar ataxia (HP:0002073)1.70738458
162Hypoproteinemia (HP:0003075)1.69887883
163Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.69866489
164Hepatic necrosis (HP:0002605)1.69711197
165Oculomotor apraxia (HP:0000657)1.68380257
166Nephrogenic diabetes insipidus (HP:0009806)1.67663788
167Pachygyria (HP:0001302)1.67198428
168Subacute progressive viral hepatitis (HP:0006572)1.65914749
169Abnormality of the lacrimal duct (HP:0011481)1.63542999
170Alopecia of scalp (HP:0002293)1.58546199
171Abnormal auditory evoked potentials (HP:0006958)1.57182685
172Abnormality of the nasolacrimal system (HP:0000614)1.57042317
173True hermaphroditism (HP:0010459)1.55588611
174Arthralgia (HP:0002829)1.55412437
175Patchy hypopigmentation of hair (HP:0011365)1.53401390
176Prostate neoplasm (HP:0100787)1.53064300
177Protruding tongue (HP:0010808)1.52841090
178Nasolacrimal duct obstruction (HP:0000579)1.51967251
179Short palm (HP:0004279)1.51676552
180Retinopathy (HP:0000488)1.51573812
181Eczematoid dermatitis (HP:0000976)1.50395831
182Short femoral neck (HP:0100864)1.50148462
183Bulbous nose (HP:0000414)1.49713335
184Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.49285024
185Septo-optic dysplasia (HP:0100842)1.49252402
186Protuberant abdomen (HP:0001538)1.48680541
187Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.48553695
188Round face (HP:0000311)1.48285083
189Cupped ribs (HP:0000887)1.47902975
190Flared metaphyses (HP:0003015)1.47228264

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.04080107
2MAP4K23.58733878
3EPHA33.54794598
4SIK33.30712781
5STK38L3.22402195
6ACVR1B3.19051084
7INSRR3.13754599
8LATS12.87643436
9CASK2.76086795
10MAP3K142.73116214
11TRPM72.66999120
12WNK32.53829197
13TLK12.48168452
14ERBB32.31366398
15ZAK2.16009645
16FLT32.11425978
17BMPR22.04181290
18IRAK32.03109459
19WNK41.99345822
20TXK1.96065835
21AKT31.90930341
22TAOK21.88132533
23NUAK11.79464410
24PASK1.77423594
25ADRBK21.73200302
26STK391.73057344
27MAP2K61.69460436
28IRAK41.67617873
29JAK31.67232575
30IRAK11.51628075
31SGK21.47938248
32OXSR11.46656704
33TRIM281.40502180
34YES11.37436874
35NLK1.35922825
36EPHA21.35511544
37STK31.34164037
38NTRK11.31699905
39CHUK1.27267147
40STK241.26413362
41MAP3K41.25931376
42GRK71.22078948
43CAMKK21.15722006
44PDK21.14015149
45CSNK1G21.10421189
46MARK31.09504631
47FGFR41.07384370
48MST41.06255206
49CSNK1G31.05262455
50CDK81.03596675
51MAPK131.03105403
52TEC1.02101207
53SIK11.01857967
54MKNK21.01838417
55EIF2AK21.01260945
56PRPF4B1.00690725
57TNIK1.00348358
58ADRBK10.99510486
59FGFR30.94416140
60MAPK150.93875890
61EPHB10.90630018
62PLK20.88859939
63TGFBR10.88529401
64MAPKAPK30.87264584
65PRKCE0.86603944
66NEK60.86539672
67PINK10.83474391
68EIF2AK30.83396541
69DAPK20.83255819
70PKN10.81576017
71BRSK20.78441817
72IKBKB0.78097508
73CSNK1A1L0.78046441
74PRKCG0.78004307
75PAK30.77021720
76MATK0.76006924
77SGK30.72961834
78PLK30.72789532
79PNCK0.70856465
80MAP3K130.70810420
81MAP2K70.70413245
82IKBKE0.70150657
83VRK10.69666966
84MAP3K50.69174187
85MUSK0.67590967
86BMPR1B0.67524486
87JAK10.66624891
88HIPK20.66399294
89BTK0.65680385
90MAP3K120.65584091
91GRK10.65090440
92DYRK20.62626595
93ERBB20.61118302
94WEE10.57502161
95TAOK30.56870491
96FRK0.55406917
97BCKDK0.55005309
98PLK40.54919517
99TGFBR20.52804303
100PTK2B0.51866600
101SGK4940.51012143
102SGK2230.51012143
103MARK10.49611072
104OBSCN0.48889302
105PRKCQ0.47727643
106TAF10.46925049
107PIM20.45254478
108PHKG20.44554151
109PHKG10.44554151
110BRAF0.43470672
111SRPK10.43016222
112FGFR20.42082275
113KIT0.42011901
114FER0.41323428
115CSNK1G10.41103151
116CSNK1A10.40823828
117BCR0.40741434
118BUB10.40299288
119CAMK2A0.39883887
120IRAK20.39677827
121MET0.39410230
122PIM10.37919323
123STK160.37788928
124LYN0.37535316
125TNK20.37289662
126PRKD30.36381684
127TBK10.35778362
128PRKCD0.35246108
129ITK0.34954893
130BRD40.34910487
131MAPKAPK50.34615709
132ERBB40.34602159
133PIK3CA0.34021223
134NTRK30.33545415
135PRKACA0.33056852
136CDK120.32717129
137IGF1R0.32496774
138CDK30.32334973
139PLK10.31074014
140MAP3K30.30648513
141PAK40.29753572
142PRKAA20.29670952
143EPHB20.29018218
144TIE10.28517576
145PRKG10.28166226
146ATR0.28089462
147RPS6KB10.27966732
148CCNB10.27932793
149PRKCA0.27735154
150SYK0.27148256
151AKT10.27056513
152ABL10.26677717
153RPS6KA50.26400074
154PIK3CG0.24804904
155PRKCH0.23802538
156MAPK30.23667019
157MKNK10.22863872
158RPS6KA60.22555948
159RPS6KA40.22077962

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.86059809
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28958988
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.20275161
4Nitrogen metabolism_Homo sapiens_hsa009102.17044696
5Butanoate metabolism_Homo sapiens_hsa006502.11522437
6Asthma_Homo sapiens_hsa053102.01753189
7Tryptophan metabolism_Homo sapiens_hsa003801.96704568
8Protein digestion and absorption_Homo sapiens_hsa049741.96377899
9ECM-receptor interaction_Homo sapiens_hsa045121.93741093
10Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.90444871
11Linoleic acid metabolism_Homo sapiens_hsa005911.86649093
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.86440595
13Selenocompound metabolism_Homo sapiens_hsa004501.84530191
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81946396
15Homologous recombination_Homo sapiens_hsa034401.80093495
16Oxidative phosphorylation_Homo sapiens_hsa001901.80070778
17Collecting duct acid secretion_Homo sapiens_hsa049661.75771534
18Basal cell carcinoma_Homo sapiens_hsa052171.75730220
19Nicotine addiction_Homo sapiens_hsa050331.70497121
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69787815
21Graft-versus-host disease_Homo sapiens_hsa053321.66778595
22Ether lipid metabolism_Homo sapiens_hsa005651.65712666
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.64893708
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.63859009
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63745909
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63375590
27Circadian rhythm_Homo sapiens_hsa047101.60641076
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60411529
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59675350
30Protein export_Homo sapiens_hsa030601.58299026
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.57113853
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.54144447
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.52936602
34Caffeine metabolism_Homo sapiens_hsa002321.51842193
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.51151374
36Type I diabetes mellitus_Homo sapiens_hsa049401.48528397
37Rheumatoid arthritis_Homo sapiens_hsa053231.48153716
38Allograft rejection_Homo sapiens_hsa053301.46294930
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44925131
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41207588
41Lysosome_Homo sapiens_hsa041421.39738795
42Leishmaniasis_Homo sapiens_hsa051401.36991727
43Measles_Homo sapiens_hsa051621.36404959
44Legionellosis_Homo sapiens_hsa051341.30053262
45Hematopoietic cell lineage_Homo sapiens_hsa046401.27816523
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27515905
47RNA polymerase_Homo sapiens_hsa030201.25775203
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22176897
49Hippo signaling pathway_Homo sapiens_hsa043901.22041636
50Wnt signaling pathway_Homo sapiens_hsa043101.21481753
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21342418
52Other glycan degradation_Homo sapiens_hsa005111.21138186
53Propanoate metabolism_Homo sapiens_hsa006401.20861581
54TNF signaling pathway_Homo sapiens_hsa046681.18231647
55Autoimmune thyroid disease_Homo sapiens_hsa053201.17989104
56Sulfur metabolism_Homo sapiens_hsa009201.16830023
57Parkinsons disease_Homo sapiens_hsa050121.15913702
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15877268
59Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12902026
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11868717
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08923326
62Regulation of autophagy_Homo sapiens_hsa041401.08783640
63TGF-beta signaling pathway_Homo sapiens_hsa043501.06446399
64Ovarian steroidogenesis_Homo sapiens_hsa049131.03780994
65ABC transporters_Homo sapiens_hsa020101.02327838
66Jak-STAT signaling pathway_Homo sapiens_hsa046301.02033953
67Herpes simplex infection_Homo sapiens_hsa051681.01581224
68Chemical carcinogenesis_Homo sapiens_hsa052040.99679145
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99509769
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99145613
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.97598265
72Prolactin signaling pathway_Homo sapiens_hsa049170.97234170
73Sphingolipid metabolism_Homo sapiens_hsa006000.96676962
74Insulin secretion_Homo sapiens_hsa049110.94358796
75Influenza A_Homo sapiens_hsa051640.93234787
76Malaria_Homo sapiens_hsa051440.93024898
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89136780
78Peroxisome_Homo sapiens_hsa041460.88825271
79Basal transcription factors_Homo sapiens_hsa030220.88651942
80Taste transduction_Homo sapiens_hsa047420.87829621
81Notch signaling pathway_Homo sapiens_hsa043300.87626718
82Glycerolipid metabolism_Homo sapiens_hsa005610.86430699
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85796972
84Fanconi anemia pathway_Homo sapiens_hsa034600.85616822
85Hepatitis C_Homo sapiens_hsa051600.85613707
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85091192
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85053519
88Melanoma_Homo sapiens_hsa052180.84397804
89Mineral absorption_Homo sapiens_hsa049780.84048888
90Hedgehog signaling pathway_Homo sapiens_hsa043400.82646494
91Arachidonic acid metabolism_Homo sapiens_hsa005900.81424757
92Hepatitis B_Homo sapiens_hsa051610.80010619
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79945813
94RNA degradation_Homo sapiens_hsa030180.79559488
95One carbon pool by folate_Homo sapiens_hsa006700.79458984
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78893907
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77327733
98GABAergic synapse_Homo sapiens_hsa047270.77282436
99Retinol metabolism_Homo sapiens_hsa008300.77196565
100Phagosome_Homo sapiens_hsa041450.77164869
101Proteasome_Homo sapiens_hsa030500.74832611
102Steroid biosynthesis_Homo sapiens_hsa001000.74715557
103Osteoclast differentiation_Homo sapiens_hsa043800.74607986
104Tuberculosis_Homo sapiens_hsa051520.74156882
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73377316
106Focal adhesion_Homo sapiens_hsa045100.72837454
107Staphylococcus aureus infection_Homo sapiens_hsa051500.72537420
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71870633
109Non-homologous end-joining_Homo sapiens_hsa034500.70276889
110Vibrio cholerae infection_Homo sapiens_hsa051100.69957688
111Salivary secretion_Homo sapiens_hsa049700.69420053
112Histidine metabolism_Homo sapiens_hsa003400.68933636
113Huntingtons disease_Homo sapiens_hsa050160.68478511
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68451566
115Colorectal cancer_Homo sapiens_hsa052100.66625005
116Type II diabetes mellitus_Homo sapiens_hsa049300.66578683
117Toxoplasmosis_Homo sapiens_hsa051450.66540516
118Endometrial cancer_Homo sapiens_hsa052130.64092860
119Prostate cancer_Homo sapiens_hsa052150.63764913
120Alzheimers disease_Homo sapiens_hsa050100.62971749
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62967106
122Circadian entrainment_Homo sapiens_hsa047130.62300394
123N-Glycan biosynthesis_Homo sapiens_hsa005100.62224092
124HTLV-I infection_Homo sapiens_hsa051660.61090687
125Primary immunodeficiency_Homo sapiens_hsa053400.60923509
126Melanogenesis_Homo sapiens_hsa049160.60655033
127Antigen processing and presentation_Homo sapiens_hsa046120.60214813
128Serotonergic synapse_Homo sapiens_hsa047260.60144829
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60058431
130Chronic myeloid leukemia_Homo sapiens_hsa052200.59765195
131Purine metabolism_Homo sapiens_hsa002300.58642272
132Phenylalanine metabolism_Homo sapiens_hsa003600.58325213
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57168465
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56890092
135Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56842474
136Chemokine signaling pathway_Homo sapiens_hsa040620.56830354
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56661711
138Pancreatic cancer_Homo sapiens_hsa052120.55933723
139Dorso-ventral axis formation_Homo sapiens_hsa043200.54011475
140Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53828508
141Glutamatergic synapse_Homo sapiens_hsa047240.53769030
142Olfactory transduction_Homo sapiens_hsa047400.53529547
143ErbB signaling pathway_Homo sapiens_hsa040120.53037928
144Glycosaminoglycan degradation_Homo sapiens_hsa005310.53033418
145Dilated cardiomyopathy_Homo sapiens_hsa054140.52702253
146Acute myeloid leukemia_Homo sapiens_hsa052210.52566669
147Lysine degradation_Homo sapiens_hsa003100.52444168
148Inositol phosphate metabolism_Homo sapiens_hsa005620.51807325
149FoxO signaling pathway_Homo sapiens_hsa040680.50751797
150Ras signaling pathway_Homo sapiens_hsa040140.50566412
151MicroRNAs in cancer_Homo sapiens_hsa052060.49837367
152African trypanosomiasis_Homo sapiens_hsa051430.49818131
153Pathways in cancer_Homo sapiens_hsa052000.49570305
154Metabolic pathways_Homo sapiens_hsa011000.48482333
155Morphine addiction_Homo sapiens_hsa050320.47237254
156Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47213155
157beta-Alanine metabolism_Homo sapiens_hsa004100.46227763
158Fatty acid elongation_Homo sapiens_hsa000620.45943478
159Fatty acid degradation_Homo sapiens_hsa000710.42958404
160Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42088881
161Glutathione metabolism_Homo sapiens_hsa004800.41594028
162Fatty acid metabolism_Homo sapiens_hsa012120.38930577
163Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38881382
164Synaptic vesicle cycle_Homo sapiens_hsa047210.38347281

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