OTOF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mutations in this gene are a cause of neurosensory nonsyndromic recessive deafness, DFNB9. The short form of the encoded protein has 3 C2 domains, a single carboxy-terminal transmembrane domain found also in the C. elegans spermatogenesis factor FER-1 and human dysferlin, while the long form has 6 C2 domains. The homology suggests that this protein may be involved in vesicle membrane fusion. Several transcript variants encoding multiple isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to type I interferon (GO:0071357)7.74988495
2type I interferon signaling pathway (GO:0060337)7.74988495
3response to type I interferon (GO:0034340)7.67632810
4response to interferon-alpha (GO:0035455)7.52499381
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.84209056
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.51625329
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.48235070
8negative regulation of cell killing (GO:0031342)6.48235070
9cellular response to interferon-alpha (GO:0035457)6.33324033
10antigen processing and presentation of endogenous antigen (GO:0019883)6.08969728
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.03360921
12negative regulation of viral genome replication (GO:0045071)5.79781657
13positive regulation by symbiont of host defense response (GO:0052509)5.74706082
14modulation by symbiont of host defense response (GO:0052031)5.74706082
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.74706082
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.74706082
17positive regulation by organism of defense response of other organism involved in symbiotic interact5.74706082
18modulation by symbiont of host immune response (GO:0052553)5.74706082
19auditory receptor cell differentiation (GO:0042491)5.66627752
20regulation of short-term neuronal synaptic plasticity (GO:0048172)5.65344802
21positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.61551313
22locomotory exploration behavior (GO:0035641)5.53828550
23synaptic vesicle maturation (GO:0016188)5.51669407
24positive regulation of gamma-delta T cell activation (GO:0046645)5.28184401
25detection of other organism (GO:0098543)5.25919960
26detection of bacterium (GO:0016045)5.21474476
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.15269803
28vocalization behavior (GO:0071625)5.08809646
29response to interferon-beta (GO:0035456)4.94579687
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.86262452
31macrophage activation involved in immune response (GO:0002281)4.77480316
32regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.73322350
33response to peptidoglycan (GO:0032494)4.69235833
34glutamate secretion (GO:0014047)4.66106493
35neuromuscular process controlling balance (GO:0050885)4.62570106
36synaptic vesicle docking involved in exocytosis (GO:0016081)4.53699141
37negative regulation of lymphocyte mediated immunity (GO:0002707)4.53671314
38neutrophil activation involved in immune response (GO:0002283)4.50935084
39* synaptic vesicle exocytosis (GO:0016079)4.50251653
40regulation of glutamate receptor signaling pathway (GO:1900449)4.47064006
41regulation of synaptic vesicle exocytosis (GO:2000300)4.43582645
42righting reflex (GO:0060013)4.41839546
43response to interleukin-15 (GO:0070672)4.38773825
44dendritic spine morphogenesis (GO:0060997)4.36982596
45detection of external biotic stimulus (GO:0098581)4.36863743
46negative regulation of interleukin-12 production (GO:0032695)4.29435292
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.28756759
48response to host immune response (GO:0052572)4.28756759
49regulation of B cell receptor signaling pathway (GO:0050855)4.27949361
50leukocyte migration involved in inflammatory response (GO:0002523)4.26819666
51interferon-gamma-mediated signaling pathway (GO:0060333)4.24040517
52immunoglobulin mediated immune response (GO:0016064)4.21381588
53positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.20351105
54cellular response to interleukin-15 (GO:0071350)4.18737008
55detection of molecule of bacterial origin (GO:0032490)4.16249244
56layer formation in cerebral cortex (GO:0021819)4.15348006
57regulation of long-term neuronal synaptic plasticity (GO:0048169)4.15051291
58regulation of neuronal synaptic plasticity (GO:0048168)4.14608200
59transmission of nerve impulse (GO:0019226)4.14496369
60ionotropic glutamate receptor signaling pathway (GO:0035235)4.14023989
61regulation of synapse structural plasticity (GO:0051823)4.11158206
62neurotransmitter secretion (GO:0007269)4.04002048
63negative regulation of leukocyte mediated immunity (GO:0002704)4.01795386
64response to host (GO:0075136)3.99674151
65response to host defenses (GO:0052200)3.99674151
66response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.99674151
67gamma-aminobutyric acid transport (GO:0015812)3.98564108
68negative regulation of T cell mediated immunity (GO:0002710)3.95904204
69exploration behavior (GO:0035640)3.95709761
70positive regulation of interferon-alpha production (GO:0032727)3.92975461
71regulation of viral genome replication (GO:0045069)3.92138206
72protein localization to synapse (GO:0035418)3.90663893
73regulation of interferon-beta biosynthetic process (GO:0045357)3.89089578
74regulation of gamma-delta T cell activation (GO:0046643)3.86500367
75regulation of synaptic vesicle transport (GO:1902803)3.83447722
76leukocyte aggregation (GO:0070486)3.80862213
77positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.80487600
78auditory behavior (GO:0031223)3.79941096
79detection of biotic stimulus (GO:0009595)3.79835122
80neutrophil activation (GO:0042119)3.79762206
81positive regulation of type 2 immune response (GO:0002830)3.79168332
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.79138688
83regulation of T cell tolerance induction (GO:0002664)3.76931754
84T cell migration (GO:0072678)3.73529709
85neuronal action potential propagation (GO:0019227)3.72281455
86regulation of type I interferon-mediated signaling pathway (GO:0060338)3.71759584
87defense response to virus (GO:0051607)3.70963112
88neuron cell-cell adhesion (GO:0007158)3.70906838
89synaptic transmission, glutamatergic (GO:0035249)3.67142418
90positive regulation of synaptic transmission, GABAergic (GO:0032230)3.64365144
91glutamate receptor signaling pathway (GO:0007215)3.63510215
92regulation of interferon-alpha production (GO:0032647)3.62384303
93regulation of dendritic spine morphogenesis (GO:0061001)3.61608619
94neurotransmitter-gated ion channel clustering (GO:0072578)3.60935603
95cellular potassium ion homeostasis (GO:0030007)3.58339445
96microglial cell activation (GO:0001774)3.57000060
97respiratory burst (GO:0045730)3.56412436
98negative regulation of viral process (GO:0048525)3.55755460
99hair cell differentiation (GO:0035315)3.55643835
100prepulse inhibition (GO:0060134)3.54363260
101regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52214983
102negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.50190962
103regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.49996247
104cellular extravasation (GO:0045123)3.47675885
105dendritic cell chemotaxis (GO:0002407)3.47194499
106neuron-neuron synaptic transmission (GO:0007270)3.47072432
107neuromuscular process (GO:0050905)3.47005516
108inner ear receptor cell differentiation (GO:0060113)3.46856505
109regulation of tolerance induction (GO:0002643)3.45817420
110activation of protein kinase A activity (GO:0034199)3.45786722
111neuronal ion channel clustering (GO:0045161)3.43609199
112long-term memory (GO:0007616)3.43479140
113granulocyte activation (GO:0036230)3.43426495
114cerebellar Purkinje cell differentiation (GO:0021702)3.42829906
115antigen processing and presentation via MHC class Ib (GO:0002475)3.39428775
116myeloid cell activation involved in immune response (GO:0002275)3.37743364
117regulation of excitatory postsynaptic membrane potential (GO:0060079)3.37652312
118regulation of type 2 immune response (GO:0002828)3.37168763
119negative regulation of innate immune response (GO:0045824)3.37119400
120positive regulation of neurotransmitter transport (GO:0051590)3.33902736
121negative regulation of type 2 immune response (GO:0002829)3.33401776
122mechanosensory behavior (GO:0007638)3.33349264
123positive regulation of T cell mediated cytotoxicity (GO:0001916)3.32379814
124regulation of T cell mediated cytotoxicity (GO:0001914)3.32347437
125positive regulation of membrane potential (GO:0045838)3.32193232
126sodium ion export (GO:0071436)3.31567217
127production of molecular mediator involved in inflammatory response (GO:0002532)3.31522363
128positive regulation of toll-like receptor signaling pathway (GO:0034123)3.30585962
129response to auditory stimulus (GO:0010996)3.30522273
130positive regulation of neurotransmitter secretion (GO:0001956)3.30074425
131B cell mediated immunity (GO:0019724)3.29777188
132positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.29692647
133negative regulation of viral entry into host cell (GO:0046597)3.29323085
134regulation of synaptic plasticity (GO:0048167)3.28527420
135cytidine deamination (GO:0009972)3.27265549
136cytidine metabolic process (GO:0046087)3.27265549
137cytidine catabolic process (GO:0006216)3.27265549
138proline transport (GO:0015824)3.25264514
139regulation of postsynaptic membrane potential (GO:0060078)3.23985496
140neuron recognition (GO:0008038)3.23283411
141germinal center formation (GO:0002467)3.21897595
142neurotransmitter transport (GO:0006836)3.21689072
143dendritic cell migration (GO:0036336)3.20206241
144mechanoreceptor differentiation (GO:0042490)3.19654195
145glycine transport (GO:0015816)3.19470616
146regulation of dendritic cell antigen processing and presentation (GO:0002604)3.17274518
147positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.16958859
148G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.15135082
149membrane hyperpolarization (GO:0060081)3.13790404
150macrophage activation (GO:0042116)3.13702475
151regulation of T-helper 2 cell differentiation (GO:0045628)3.11814647
152negative regulation of cytokine production involved in immune response (GO:0002719)3.09638636
153pyrimidine ribonucleoside catabolic process (GO:0046133)3.08798168
154lymphocyte chemotaxis (GO:0048247)3.08788818
155cellular response to interferon-gamma (GO:0071346)3.08100242
156response to muramyl dipeptide (GO:0032495)3.05568923
157cellular response to virus (GO:0098586)3.05401183
158positive regulation of interferon-beta production (GO:0032728)3.04063972
159cellular sodium ion homeostasis (GO:0006883)3.03698529
160regulation of mast cell degranulation (GO:0043304)3.03056799
161dendritic spine organization (GO:0097061)3.02031025
162response to interferon-gamma (GO:0034341)3.01514439
163activated T cell proliferation (GO:0050798)3.01334228
164regulation of viral entry into host cell (GO:0046596)3.01286821
165regulation of neurotransmitter levels (GO:0001505)3.01215508
166regulation of gamma-delta T cell differentiation (GO:0045586)3.01202955
167vesicle transport along microtubule (GO:0047496)3.00922558
168axonal fasciculation (GO:0007413)2.98474624
169B cell receptor signaling pathway (GO:0050853)2.98363927
170neuromuscular process controlling posture (GO:0050884)2.98168006
171regulation of dendritic spine development (GO:0060998)2.96719691
172regulation of toll-like receptor signaling pathway (GO:0034121)2.96122086
173negative regulation of cytosolic calcium ion concentration (GO:0051481)2.96029503
174regulation of synaptic transmission, glutamatergic (GO:0051966)2.95819364
175regulation of T cell mediated immunity (GO:0002709)2.93682673
176regulation of neurotransmitter secretion (GO:0046928)2.89596357
177regulation of glutamate secretion (GO:0014048)2.86951729
178regulation of vesicle fusion (GO:0031338)2.86153611
179dopamine receptor signaling pathway (GO:0007212)2.84672154
180long term synaptic depression (GO:0060292)2.84555288
181synapse assembly (GO:0007416)2.84266604
182long-term synaptic potentiation (GO:0060291)2.83122389
183behavioral response to cocaine (GO:0048148)2.82799102
184adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.82235630
185cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.82180858
186striatum development (GO:0021756)2.81338518
187postsynaptic membrane organization (GO:0001941)2.80632862
188mating behavior (GO:0007617)2.80039333
189pentose metabolic process (GO:0019321)2.79459099
190synaptic vesicle endocytosis (GO:0048488)2.79207158
191regulation of voltage-gated calcium channel activity (GO:1901385)2.78590193
192regulation of neurotransmitter transport (GO:0051588)2.77107752
193dendrite morphogenesis (GO:0048813)2.76770924
194cytoskeletal anchoring at plasma membrane (GO:0007016)2.76624111
195membrane depolarization during action potential (GO:0086010)2.76136271
196membrane depolarization (GO:0051899)2.75483092
197* sensory perception of mechanical stimulus (GO:0050954)2.75168942
198cell communication by electrical coupling (GO:0010644)2.75111501
199startle response (GO:0001964)2.73610134
200behavioral defense response (GO:0002209)2.73602871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.03870485
2EZH2_22144423_ChIP-Seq_EOC_Human5.24789317
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.13446573
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.57196866
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.33810070
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.54140845
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.38161264
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.12899681
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08357261
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.97222328
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96963786
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96416914
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90055985
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78642194
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78642194
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66560370
17* DROSHA_22980978_ChIP-Seq_HELA_Human2.63647891
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62235548
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56114457
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54752741
21GBX2_23144817_ChIP-Seq_PC3_Human2.54611953
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.54213352
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49248302
24VDR_21846776_ChIP-Seq_THP-1_Human2.47550716
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44769197
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.44354444
27* VDR_24763502_ChIP-Seq_THP-1_Human2.42734696
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42410469
29REST_21632747_ChIP-Seq_MESCs_Mouse2.40325067
30MAF_26560356_Chip-Seq_TH1_Human2.37851828
31SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37643820
32RUNX_20019798_ChIP-Seq_JUKART_Human2.36649654
33EZH2_27294783_Chip-Seq_ESCs_Mouse2.34969857
34SPI1_23127762_ChIP-Seq_K562_Human2.30997246
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30013102
36RNF2_27304074_Chip-Seq_ESCs_Mouse2.25609473
37SPI1_23547873_ChIP-Seq_NB4_Human2.21132923
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20619422
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.20310028
40EED_16625203_ChIP-ChIP_MESCs_Mouse2.19683143
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19485128
42MYB_26560356_Chip-Seq_TH2_Human2.17245887
43STAT4_19710469_ChIP-ChIP_TH1__Mouse2.16673549
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14510375
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.13255262
46AR_21572438_ChIP-Seq_LNCaP_Human2.12509593
47MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12488839
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06726683
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02498396
50KDM2B_26808549_Chip-Seq_SUP-B15_Human2.00932212
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.97873466
52UTX_26944678_Chip-Seq_JUKART_Human1.95868606
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95431848
54MYC_22102868_ChIP-Seq_BL_Human1.91165172
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90947770
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.88790151
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.87213085
58KDM2B_26808549_Chip-Seq_DND41_Human1.80895311
59MAF_26560356_Chip-Seq_TH2_Human1.79885454
60MYB_26560356_Chip-Seq_TH1_Human1.79857256
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79326604
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.78148101
63* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78014833
64TCF7_22412390_ChIP-Seq_EML_Mouse1.76934570
65GATA1_22025678_ChIP-Seq_K562_Human1.76742861
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75579761
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73796528
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69551767
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67592072
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67033454
71* VDR_24787735_ChIP-Seq_THP-1_Human1.63675746
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63377228
73GATA3_27048872_Chip-Seq_THYMUS_Human1.62725190
74SCL_19346495_ChIP-Seq_HPC-7_Human1.62582574
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59604219
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55562692
77LXR_22292898_ChIP-Seq_THP-1_Human1.54968655
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53743935
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52187865
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48609458
81DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47722486
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47235349
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.46696982
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45645453
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45268817
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.43747385
87* GATA1_19941827_ChIP-Seq_MEL_Mouse1.38962976
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37196579
89SMAD4_21799915_ChIP-Seq_A2780_Human1.36767621
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32393719
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31514972
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30897183
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28757616
94KDM2B_26808549_Chip-Seq_K562_Human1.27932616
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.27514526
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27059196
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26582575
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.26438791
99* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26155362
100GATA3_26560356_Chip-Seq_TH2_Human1.25360331
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24577372
102CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24182186
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.23940318
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23698271
105SMAD3_21741376_ChIP-Seq_EPCs_Human1.23502359
106RING1B_27294783_Chip-Seq_NPCs_Mouse1.23190803
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.22008802
108AHR_22903824_ChIP-Seq_MCF-7_Human1.21000307
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20606787
110KDM2B_26808549_Chip-Seq_JURKAT_Human1.20476213
111* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20467179
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19284942
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16202208
114BCL6_27268052_Chip-Seq_Bcells_Human1.15932703
115GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14740237
116TP53_18474530_ChIP-ChIP_U2OS_Human1.14141785
117RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13863025
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13764869
119CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13302887
120TAF15_26573619_Chip-Seq_HEK293_Human1.13255716
121GATA2_21666600_ChIP-Seq_HMVEC_Human1.12933583
122AR_19668381_ChIP-Seq_PC3_Human1.12624847
123NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12441445
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11973012
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11695986
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10685339
127ZNF274_21170338_ChIP-Seq_K562_Hela1.10182856
128CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10119917
129SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10083039
130BCOR_27268052_Chip-Seq_Bcells_Human1.09684195
131FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09395852
132* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08611934
133GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08459626
134PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07011102
135CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06740501
136AR_25329375_ChIP-Seq_VCAP_Human1.06232035
137PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06092166
138SMAD_19615063_ChIP-ChIP_OVARY_Human1.05685326
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05159806
140STAT3_23295773_ChIP-Seq_U87_Human1.03950167
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03786937
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03786937
143RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03503607
144GATA1_19941826_ChIP-Seq_K562_Human1.03346658
145RXR_22108803_ChIP-Seq_LS180_Human1.03240652
146SMAD3_21741376_ChIP-Seq_ESCs_Human1.02165629
147YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02023692
148PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01056416
149GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00952850
150OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00663358
151BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99832564
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99196016
153P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99008879
154ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98649482
155CTCF_27219007_Chip-Seq_Bcells_Human0.98468173
156GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98409306
157SMAD4_21741376_ChIP-Seq_HESCs_Human0.98012396
158SA1_27219007_Chip-Seq_ERYTHROID_Human0.97852137
159SMAD3_21741376_ChIP-Seq_HESCs_Human0.97733673
160AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97701125
161* P300_19829295_ChIP-Seq_ESCs_Human0.97577618
162TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97343627
163PU_27001747_Chip-Seq_BMDM_Mouse0.97238524
164SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96731700
165MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96001281
166GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95700267
167CBX2_27304074_Chip-Seq_ESCs_Mouse0.94947122
168TRIM28_21343339_ChIP-Seq_HEK293_Human0.92496131
169ELF1_20517297_ChIP-Seq_JURKAT_Human0.91745435
170CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91742252
171TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91652037
172CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90499499
173ESR2_21235772_ChIP-Seq_MCF-7_Human0.90350071
174PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90258421
175CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88203064
176EP300_21415370_ChIP-Seq_HL-1_Mouse0.87987013
177NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87847669
178DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87759485
179* TCF4_23295773_ChIP-Seq_U87_Human0.87423026
180TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87325254
181SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87289186
182RACK7_27058665_Chip-Seq_MCF-7_Human0.85869738
183BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85342278
184* RUNX2_22187159_ChIP-Seq_PCA_Human0.83970414
185TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83924681
186EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83266774
187PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81819208
188SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.81304661
189SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80401669
190EGR1_19032775_ChIP-ChIP_M12_Human0.79968497
191CTCF_26484167_Chip-Seq_Bcells_Mouse0.79489626
192P68_20966046_ChIP-Seq_HELA_Human0.77841522
193SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.77645054
194SPI1_20517297_ChIP-Seq_HL60_Human0.77643769
195STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77628770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to6.31220511
2MP0004859_abnormal_synaptic_plasticity5.38353572
3MP0003878_abnormal_ear_physiology5.27707718
4MP0005377_hearing/vestibular/ear_phenot5.27707718
5* MP0003879_abnormal_hair_cell5.10639072
6* MP0001485_abnormal_pinna_reflex4.47217581
7MP0001835_abnormal_antigen_presentation4.10322570
8MP0003436_decreased_susceptibility_to4.04724566
9MP0003880_abnormal_central_pattern3.77575767
10MP0009785_altered_susceptibility_to3.68482774
11* MP0001486_abnormal_startle_reflex3.65914013
12MP0003635_abnormal_synaptic_transmissio3.34273896
13MP0005671_abnormal_response_to3.32190516
14MP0005025_abnormal_response_to3.26546098
15MP0002822_catalepsy3.26309225
16MP0006082_CNS_inflammation3.21889862
17MP0002419_abnormal_innate_immunity3.10222034
18MP0005387_immune_system_phenotype3.04600626
19MP0001790_abnormal_immune_system3.04600626
20MP0001800_abnormal_humoral_immune2.99596859
21MP0005000_abnormal_immune_tolerance2.97091085
22MP0004270_analgesia2.97004293
23MP0003303_peritoneal_inflammation2.89630232
24MP0000685_abnormal_immune_system2.75324786
25MP0002723_abnormal_immune_serum2.72772618
26MP0009745_abnormal_behavioral_response2.72574694
27MP0002063_abnormal_learning/memory/cond2.59367417
28MP0009046_muscle_twitch2.52959794
29MP0002420_abnormal_adaptive_immunity2.52560297
30MP0002452_abnormal_antigen_presenting2.50753061
31MP0001819_abnormal_immune_cell2.50617553
32* MP0000026_abnormal_inner_ear2.44158060
33* MP0001963_abnormal_hearing_physiology2.43332931
34MP0002064_seizures2.40349579
35MP0004742_abnormal_vestibular_system2.34948634
36MP0002272_abnormal_nervous_system2.29173242
37MP0002148_abnormal_hypersensitivity_rea2.26266895
38MP0001533_abnormal_skeleton_physiology2.24554227
39MP0003300_gastrointestinal_ulcer2.23133310
40MP0002572_abnormal_emotion/affect_behav2.16678699
41MP0002132_abnormal_respiratory_system2.02863283
42MP0003763_abnormal_thymus_physiology2.00300390
43MP0001968_abnormal_touch/_nociception1.99859743
44MP0005423_abnormal_somatic_nervous1.99319980
45MP0003191_abnormal_cellular_cholesterol1.95107075
46MP0002405_respiratory_system_inflammati1.94980732
47MP0010155_abnormal_intestine_physiology1.92901561
48MP0000465_gastrointestinal_hemorrhage1.91436824
49MP0000716_abnormal_immune_system1.88341477
50MP0002277_abnormal_respiratory_mucosa1.87893307
51MP0005248_abnormal_Harderian_gland1.85182602
52MP0002398_abnormal_bone_marrow1.84303468
53MP0003866_abnormal_defecation1.81771231
54MP0004885_abnormal_endolymph1.81011196
55MP0002734_abnormal_mechanical_nocicepti1.80254363
56MP0004510_myositis1.74285109
57MP0009780_abnormal_chondrocyte_physiolo1.72336039
58MP0009333_abnormal_splenocyte_physiolog1.71070465
59MP0006276_abnormal_autonomic_nervous1.70153412
60MP0001845_abnormal_inflammatory_respons1.70033833
61MP0001501_abnormal_sleep_pattern1.67960383
62MP0008469_abnormal_protein_level1.64663340
63MP0008260_abnormal_autophagy1.64344814
64MP0003828_pulmonary_edema1.64163282
65MP0002184_abnormal_innervation1.63884687
66MP0002067_abnormal_sensory_capabilities1.63607491
67MP0005645_abnormal_hypothalamus_physiol1.57333845
68MP0004947_skin_inflammation1.56134901
69MP0001502_abnormal_circadian_rhythm1.55759582
70MP0005310_abnormal_salivary_gland1.54784321
71MP0001440_abnormal_grooming_behavior1.53620317
72MP0005464_abnormal_platelet_physiology1.53352858
73MP0003183_abnormal_peptide_metabolism1.53328365
74MP0002909_abnormal_adrenal_gland1.48062244
75MP0009278_abnormal_bone_marrow1.46329956
76MP0002429_abnormal_blood_cell1.45023407
77MP0000689_abnormal_spleen_morphology1.43849150
78MP0002722_abnormal_immune_system1.43318491
79MP0002557_abnormal_social/conspecific_i1.41976832
80MP0009764_decreased_sensitivity_to1.41334792
81MP0008569_lethality_at_weaning1.40244014
82MP0002396_abnormal_hematopoietic_system1.37956703
83MP0003329_amyloid_beta_deposits1.36843122
84MP0000703_abnormal_thymus_morphology1.34656190
85MP0004811_abnormal_neuron_physiology1.34255450
86MP0002736_abnormal_nociception_after1.34244479
87MP0001970_abnormal_pain_threshold1.33269420
88MP0002733_abnormal_thermal_nociception1.33147131
89MP0005451_abnormal_body_composition1.32598608
90MP0000778_abnormal_nervous_system1.32089572
91* MP0002882_abnormal_neuron_morphology1.31560437
92MP0000858_altered_metastatic_potential1.30724169
93MP0004858_abnormal_nervous_system1.29663588
94MP0003787_abnormal_imprinting1.23747661
95MP0010234_abnormal_vibrissa_follicle1.21533266
96MP0002066_abnormal_motor_capabilities/c1.21156520
97MP0005386_behavior/neurological_phenoty1.19009145
98MP0004924_abnormal_behavior1.19009145
99MP0000955_abnormal_spinal_cord1.18341095
100MP0002229_neurodegeneration1.16139891
101MP0002653_abnormal_ependyma_morphology1.15758029
102MP0001851_eye_inflammation1.14893703
103MP0003938_abnormal_ear_development1.11681208
104MP0000343_altered_response_to1.11551388
105MP0005646_abnormal_pituitary_gland1.09426040
106MP0005623_abnormal_meninges_morphology1.09344244
107MP0003283_abnormal_digestive_organ1.09076572
108MP0003806_abnormal_nucleotide_metabolis1.07857186
109MP0002166_altered_tumor_susceptibility1.07301241
110MP0002998_abnormal_bone_remodeling1.07081112
111MP0002735_abnormal_chemical_nociception1.06441464
112MP0003633_abnormal_nervous_system1.03394816
113MP0001873_stomach_inflammation1.01593437
114MP0003122_maternal_imprinting1.00793594
115MP0005166_decreased_susceptibility_to0.99343403
116MP0004883_abnormal_blood_vessel0.98258028
117MP0009763_increased_sensitivity_to0.98210344
118MP0001529_abnormal_vocalization0.97473560
119MP0005390_skeleton_phenotype0.97439032
120MP0001984_abnormal_olfaction0.97035345
121MP0003172_abnormal_lysosome_physiology0.96951764
122MP0003448_altered_tumor_morphology0.96335436
123* MP0002752_abnormal_somatic_nervous0.92652046
124MP0001986_abnormal_taste_sensitivity0.91937562
125MP0001177_atelectasis0.91872744
126MP0005397_hematopoietic_system_phenotyp0.91457999
127MP0001545_abnormal_hematopoietic_system0.91457999
128MP0002152_abnormal_brain_morphology0.86569543
129MP0003690_abnormal_glial_cell0.86490728
130MP0004381_abnormal_hair_follicle0.85006825
131MP0000751_myopathy0.84904711
132MP0001905_abnormal_dopamine_level0.83835033
133MP0004142_abnormal_muscle_tone0.82861292
134MP0003075_altered_response_to0.81602685
135MP0000631_abnormal_neuroendocrine_gland0.81121548
136MP0003631_nervous_system_phenotype0.80968412
137MP0001853_heart_inflammation0.77521835
138MP0000534_abnormal_ureter_morphology0.74633225
139MP0004145_abnormal_muscle_electrophysio0.74287124
140MP0008961_abnormal_basal_metabolism0.73779886
141MP0005535_abnormal_body_temperature0.72151879
142MP0004085_abnormal_heartbeat0.70854373
143MP0002138_abnormal_hepatobiliary_system0.70853841
144MP0005164_abnormal_response_to0.70844204
145MP0003221_abnormal_cardiomyocyte_apopto0.70312262
146MP0005083_abnormal_biliary_tract0.69758346
147MP0001299_abnormal_eye_distance/0.69045246
148MP0000920_abnormal_myelination0.68945094
149MP0005167_abnormal_blood-brain_barrier0.68915494
150MP0009765_abnormal_xenobiotic_induced0.68240644
151MP0008874_decreased_physiological_sensi0.67389254
152MP0002332_abnormal_exercise_endurance0.67190704
153MP0008872_abnormal_physiological_respon0.66755274
154MP0002069_abnormal_eating/drinking_beha0.66187914
155MP0000013_abnormal_adipose_tissue0.66015658
156MP0008004_abnormal_stomach_pH0.65111234
157MP0003634_abnormal_glial_cell0.64853872
158MP0001663_abnormal_digestive_system0.64474574
159MP0002933_joint_inflammation0.62279563
160MP0005551_abnormal_eye_electrophysiolog0.61252409
161MP0002006_tumorigenesis0.60287437
162MP0001346_abnormal_lacrimal_gland0.60041289
163MP0002168_other_aberrant_phenotype0.59648684
164MP0003795_abnormal_bone_structure0.58840210
165MP0000490_abnormal_crypts_of0.58727279
166MP0004808_abnormal_hematopoietic_stem0.58384943
167MP0001943_abnormal_respiration0.57922731
168MP0000569_abnormal_digit_pigmentation0.57588537
169MP0005319_abnormal_enzyme/_coenzyme0.56344012
170MP0003632_abnormal_nervous_system0.56102255
171MP0003137_abnormal_impulse_conducting0.55456211
172MP0000604_amyloidosis0.55254405
173MP0003045_fibrosis0.54527789
174MP0003123_paternal_imprinting0.53733571
175MP0002928_abnormal_bile_duct0.52517554
176MP0002693_abnormal_pancreas_physiology0.48545913
177MP0003861_abnormal_nervous_system0.48424171
178MP0005187_abnormal_penis_morphology0.46782047
179MP0005409_darkened_coat_color0.46764085
180MP0000249_abnormal_blood_vessel0.46713883
181MP0002089_abnormal_postnatal_growth/wei0.46670383
182MP0009115_abnormal_fat_cell0.46632020
183MP0003942_abnormal_urinary_system0.46003021
184MP0001348_abnormal_lacrimal_gland0.45526222
185MP0004130_abnormal_muscle_cell0.42989988
186MP0002090_abnormal_vision0.40838143
187MP0002249_abnormal_larynx_morphology0.39050328
188MP0004484_altered_response_of0.38387739

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.72625213
2Eczematoid dermatitis (HP:0000976)6.48383872
3Hypochromic microcytic anemia (HP:0004840)6.38436457
4Myositis (HP:0100614)6.32810768
5Focal motor seizures (HP:0011153)6.26398439
6Orchitis (HP:0100796)6.19576860
7Retrobulbar optic neuritis (HP:0100654)5.99036966
8Optic neuritis (HP:0100653)5.99036966
9Recurrent abscess formation (HP:0002722)5.42807233
10Abnormality of macrophages (HP:0004311)5.36533452
11Recurrent bacterial skin infections (HP:0005406)5.24322285
12Gastrointestinal infarctions (HP:0005244)5.06991172
13Elevated erythrocyte sedimentation rate (HP:0003565)5.05582565
14Focal seizures (HP:0007359)4.97569643
15Hypochromic anemia (HP:0001931)4.48970525
16Recurrent gram-negative bacterial infections (HP:0005420)4.47475823
17Stomatitis (HP:0010280)4.39396893
18Keratoconjunctivitis sicca (HP:0001097)4.23980186
19Recurrent fungal infections (HP:0002841)4.21777042
20Epiphyseal dysplasia (HP:0002656)4.21502145
21Visual hallucinations (HP:0002367)4.17739632
22Chronic mucocutaneous candidiasis (HP:0002728)4.16487586
23Recurrent cutaneous fungal infections (HP:0011370)4.16487586
24Abnormal delayed hypersensitivity skin test (HP:0002963)4.12713140
25Mediastinal lymphadenopathy (HP:0100721)4.11553303
26Meningitis (HP:0001287)4.04206952
27Keratoconjunctivitis (HP:0001096)3.91644761
28Chronic obstructive pulmonary disease (HP:0006510)3.89862598
29Obstructive lung disease (HP:0006536)3.89862598
30Recurrent skin infections (HP:0001581)3.84639072
31Encephalitis (HP:0002383)3.79220053
32Epileptic encephalopathy (HP:0200134)3.75869795
33Vasculitis (HP:0002633)3.72832386
34Action tremor (HP:0002345)3.67415332
35Gingivitis (HP:0000230)3.65728194
36Ankle clonus (HP:0011448)3.45839888
37Hemoptysis (HP:0002105)3.42583527
38Increased IgE level (HP:0003212)3.40432807
39Progressive cerebellar ataxia (HP:0002073)3.36695695
40Supranuclear gaze palsy (HP:0000605)3.33782058
41Absence seizures (HP:0002121)3.29534978
42Atonic seizures (HP:0010819)3.27068088
43Spontaneous hematomas (HP:0007420)3.26800974
44Generalized tonic-clonic seizures (HP:0002069)3.26168223
45Chest pain (HP:0100749)3.24797920
46Peritonitis (HP:0002586)3.19843460
47Pulmonary infiltrates (HP:0002113)3.16720407
48Urticaria (HP:0001025)3.06315937
49Vitreoretinal degeneration (HP:0000655)3.04795828
50Febrile seizures (HP:0002373)3.04500270
51Cellulitis (HP:0100658)3.04417560
52Poor eye contact (HP:0000817)3.03379275
53Depression (HP:0000716)3.01868786
54Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.00993388
55Microcytic anemia (HP:0001935)2.99984712
56Broad-based gait (HP:0002136)2.98495819
57Increased IgM level (HP:0003496)2.98160932
58Episodic fever (HP:0001954)2.93089773
59Prolonged bleeding time (HP:0003010)2.92895400
60Anorexia (HP:0002039)2.90416282
61Anxiety (HP:0000739)2.90268644
62Dialeptic seizures (HP:0011146)2.88939286
63Toxemia of pregnancy (HP:0100603)2.88132398
64Arterial thrombosis (HP:0004420)2.87897175
65Recurrent viral infections (HP:0004429)2.86223332
66Torticollis (HP:0000473)2.83832048
67Abnormal social behavior (HP:0012433)2.81659055
68Impaired social interactions (HP:0000735)2.81659055
69Impaired vibration sensation in the lower limbs (HP:0002166)2.78757056
70Papilledema (HP:0001085)2.76202619
71Postural instability (HP:0002172)2.74871292
72Urinary bladder sphincter dysfunction (HP:0002839)2.74279120
73Dysdiadochokinesis (HP:0002075)2.73159564
74Abnormal hemoglobin (HP:0011902)2.72569856
75Leukocytosis (HP:0001974)2.69713997
76Pulmonary embolism (HP:0002204)2.69479665
77Panhypogammaglobulinemia (HP:0003139)2.69055198
78Aplasia involving bones of the upper limbs (HP:0009823)2.67107520
79Aplasia of the phalanges of the hand (HP:0009802)2.67107520
80Aplasia involving bones of the extremities (HP:0009825)2.67107520
81Neurofibrillary tangles (HP:0002185)2.66596416
82Chronic otitis media (HP:0000389)2.63887305
83Genetic anticipation (HP:0003743)2.63501222
84Dysmetria (HP:0001310)2.60604021
85Osteomyelitis (HP:0002754)2.59955792
86Annular pancreas (HP:0001734)2.59876473
87Inflammation of the large intestine (HP:0002037)2.59066954
88Abnormal eating behavior (HP:0100738)2.58819739
89Abnormality of the pericardium (HP:0001697)2.58252679
90Abnormality of the heme biosynthetic pathway (HP:0010472)2.57072451
91Gingival bleeding (HP:0000225)2.55042902
92Cerebral inclusion bodies (HP:0100314)2.53042217
93Gastrointestinal inflammation (HP:0004386)2.52549630
94Hypergammaglobulinemia (HP:0010702)2.52065117
95Abnormality of T cell number (HP:0011839)2.51709884
96Gaze-evoked nystagmus (HP:0000640)2.51241440
97Abnormality of the peritoneum (HP:0002585)2.50947714
98Truncal ataxia (HP:0002078)2.48432812
99Abnormality of the pleura (HP:0002103)2.47756854
100T lymphocytopenia (HP:0005403)2.47237256
101Abnormality of the endocardium (HP:0004306)2.45133441
102Mutism (HP:0002300)2.44068163
103Focal dystonia (HP:0004373)2.43672153
104Severe Myopia (HP:0011003)2.43125283
105Congenital sensorineural hearing impairment (HP:0008527)2.42786165
106Nasal polyposis (HP:0100582)2.42224305
107Pointed chin (HP:0000307)2.39211695
108Abnormality of T cells (HP:0002843)2.38246066
109Hemiplegia (HP:0002301)2.36670126
110Arterial tortuosity (HP:0005116)2.36518264
111Amyloidosis (HP:0011034)2.36185101
112Pustule (HP:0200039)2.35720173
113Urinary urgency (HP:0000012)2.34798344
114Epistaxis (HP:0000421)2.33826497
115Amblyopia (HP:0000646)2.33547422
116Acute hepatic failure (HP:0006554)2.32959951
117Impaired smooth pursuit (HP:0007772)2.29933007
118Petechiae (HP:0000967)2.29825282
119Hypoplastic ischia (HP:0003175)2.28299053
120Granulocytopenia (HP:0001913)2.28144576
121Intention tremor (HP:0002080)2.27665006
122Mild short stature (HP:0003502)2.27213585
123Mixed hearing impairment (HP:0000410)2.26904894
124Cheilitis (HP:0100825)2.26801473
125Polycythemia (HP:0001901)2.26661911
126Craniofacial dystonia (HP:0012179)2.26637051
127Hemiparesis (HP:0001269)2.26423163
128Spastic gait (HP:0002064)2.26383010
129Gangrene (HP:0100758)2.26318501
130Vertigo (HP:0002321)2.24923694
131Insomnia (HP:0100785)2.24692017
132Sepsis (HP:0100806)2.24329151
133Colitis (HP:0002583)2.24071813
134Stereotypic behavior (HP:0000733)2.23596884
135Abnormality of the lower motor neuron (HP:0002366)2.23032910
136Lower limb amyotrophy (HP:0007210)2.22527177
137Scanning speech (HP:0002168)2.22226723
138Acne (HP:0001061)2.20516437
139Glomerulopathy (HP:0100820)2.19875149
140Abnormality of T cell physiology (HP:0011840)2.19330000
141Skin ulcer (HP:0200042)2.17099284
142Hyperventilation (HP:0002883)2.16640281
143Abnormality of the pubic bones (HP:0003172)2.16153628
144Ventricular fibrillation (HP:0001663)2.15918548
145Loss of speech (HP:0002371)2.14396083
146Drooling (HP:0002307)2.13585761
147Excessive salivation (HP:0003781)2.13585761
148Keratitis (HP:0000491)2.13037017
149Ankyloglossia (HP:0010296)2.12535466
150Malnutrition (HP:0004395)2.11238293
151Megalencephaly (HP:0001355)2.11091715
152Resting tremor (HP:0002322)2.09637946
153Dysmetric saccades (HP:0000641)2.08528194
154Irregular epiphyses (HP:0010582)2.07277001
155Abnormality of the nasal mucosa (HP:0000433)2.05682137
156Lymphopenia (HP:0001888)2.03582424
157Abnormal ciliary motility (HP:0012262)2.03244196
158Recurrent bronchitis (HP:0002837)2.02607007
159Vascular tortuosity (HP:0004948)2.01183671
160Abnormality of cells of the lymphoid lineage (HP:0012140)2.00813551
161Bradykinesia (HP:0002067)1.99934293
162Agitation (HP:0000713)1.99340720
163Abnormality of binocular vision (HP:0011514)1.98457950
164Diplopia (HP:0000651)1.98457950
165Purpura (HP:0000979)1.96801193
166Fetal akinesia sequence (HP:0001989)1.95350825
167Premature loss of primary teeth (HP:0006323)1.94715035
168Abnormality of the ischium (HP:0003174)1.94617832
169Clonus (HP:0002169)1.93636240
170Polyneuropathy (HP:0001271)1.93621397
171Agammaglobulinemia (HP:0004432)1.93324437
172Insidious onset (HP:0003587)1.92260067
173Termporal pattern (HP:0011008)1.92260067
174Abnormality of ocular smooth pursuit (HP:0000617)1.92176351
175Progressive inability to walk (HP:0002505)1.91863566
176Status epilepticus (HP:0002133)1.91552231
177Obstructive sleep apnea (HP:0002870)1.91013219
178Epileptiform EEG discharges (HP:0011182)1.88449563
179Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.88007533
180Eosinophilia (HP:0001880)1.87675225
181Recurrent pneumonia (HP:0006532)1.85040974
182EEG with generalized epileptiform discharges (HP:0011198)1.83436045
183Peripheral hypomyelination (HP:0007182)1.83356846
184Lower limb muscle weakness (HP:0007340)1.82840631
185Distal arthrogryposis (HP:0005684)1.81204242
186Skin rash (HP:0000988)1.80643790
187Hypermelanotic macule (HP:0001034)1.80588794
188Aseptic necrosis (HP:0010885)1.80468258
189Autoimmune hemolytic anemia (HP:0001890)1.80235744
190Impaired vibratory sensation (HP:0002495)1.79697111
191Abnormal EKG (HP:0003115)1.79457137
192Hepatoblastoma (HP:0002884)1.79399907
193Difficulty running (HP:0009046)1.78526601
194Abnormal respiratory motile cilium physiology (HP:0012261)1.78436788
195Prolonged QT interval (HP:0001657)1.77767576
196Slow saccadic eye movements (HP:0000514)1.77617421
197Hypsarrhythmia (HP:0002521)1.77405882
198Abnormality of the corticospinal tract (HP:0002492)1.75773434
199Midline defect of the nose (HP:0004122)1.74694495
200Neuronal loss in central nervous system (HP:0002529)1.70921743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.90487787
2NTRK34.14631008
3MAP3K94.09962036
4TYK23.93980642
5MAP4K13.65479165
6BLK3.07660792
7DAPK22.74019953
8ERN12.71773799
9IKBKE2.69643864
10IRAK42.67159526
11MAP2K32.56569044
12DDR22.48557801
13FGFR42.46264065
14CSK2.43055996
15MAP3K42.39793016
16JAK12.36148989
17NTRK12.34275862
18KSR22.28012679
19MARK12.27570053
20MINK12.27212258
21PRKD32.23037669
22JAK32.14663659
23PAK62.12386632
24NTRK22.06856364
25TBK12.03458896
26ZAP702.01311733
27CAMKK11.95201754
28KIT1.91095916
29FGFR31.84442347
30GRK61.78279688
31TXK1.72773104
32BTK1.66953877
33RIPK41.64669982
34HCK1.64173351
35CDK51.60700652
36MAP2K71.58072672
37KSR11.49687940
38MAP2K41.47448549
39TAOK11.46639324
40JAK21.46358726
41TNIK1.45209903
42SYK1.44490794
43MAP3K131.44274609
44MAP3K111.42152896
45DAPK11.40440905
46FGR1.39543867
47MAP3K121.38374871
48SIK21.36565945
49STK381.35033338
50UHMK11.34016472
51MAP3K31.32675113
52MAP3K21.30732821
53EPHB11.28839655
54FES1.28055510
55PAK31.28055124
56CDK191.23710972
57ARAF1.22427744
58LYN1.22082916
59PNCK1.18982039
60LCK1.18590302
61ALK1.17800824
62PRKD21.17072792
63TYRO31.16059042
64MAP3K61.14763795
65SIK31.08531849
66PRKCH1.01411819
67PLK21.01323866
68SMG11.00406361
69PRKCG0.98617712
70EPHA20.98613132
71ITK0.95854518
72MAPK150.94742713
73YES10.91954209
74PRPF4B0.91217581
75RET0.90754133
76LATS20.90358036
77PTK60.89700667
78MAPK130.89290676
79CAMK10.89258626
80CSF1R0.89163060
81MAP3K140.88069647
82RIPK10.87366825
83STK110.87325112
84MAP3K10.87243837
85MATK0.84831509
86TAOK30.82134442
87CAMKK20.82102110
88GRK50.81343080
89FER0.79921223
90WNK10.79193042
91DMPK0.78927224
92SGK4940.77208246
93SGK2230.77208246
94CAMK2A0.75839174
95CDK140.75266924
96CDK150.74663187
97CDK180.73908420
98RAF10.72843591
99CAMK1G0.72170253
100CDC42BPA0.71903043
101IRAK10.70806382
102CAMK2B0.69693986
103MAPK70.69651133
104MARK20.68413430
105MARK30.67420601
106SGK10.67139308
107EPHA30.66684216
108CASK0.66682196
109PHKG20.65948226
110PHKG10.65948226
111MAPK120.64395183
112CDK11A0.63668412
113IKBKB0.63012736
114SGK30.62775952
115OXSR10.62377403
116PIK3CG0.61531045
117TEC0.61152624
118PRKCE0.60453438
119LMTK20.59593643
120SGK20.58933815
121HIPK20.58397981
122TAOK20.58378280
123TESK20.58346753
124NEK60.58275489
125PTK2B0.57149270
126BMX0.56777412
127CSNK1G20.56615227
128GRK70.55682890
129FYN0.55303424
130PDPK10.54316703
131RPS6KA30.54052239
132MAPK110.53687194
133PINK10.53298529
134PRKCZ0.50670103
135MAP3K50.48783447
136PDK10.48571839
137STK100.48161005
138MAP2K60.47790035
139DYRK1B0.47559725
140TNK20.47518328
141BMPR20.47498742
142IRAK20.47079366
143DYRK1A0.45444397
144MAPK100.44467073
145ERBB20.43545628
146CSNK1A1L0.42294548
147MAP2K10.42204190
148SIK10.41688119
149TRIB30.41303898
150ROCK20.41294994
151PRKG20.40957694
152NLK0.40809198
153CAMK40.40501994
154MAP3K70.40201358
155DAPK30.38860939
156STK390.37813512
157CDK120.37088271
158PRKCQ0.35953121
159WNK40.35726517
160SCYL20.34055646
161LRRK20.33496283
162RPS6KC10.28062802
163RPS6KL10.28062802
164PRKCD0.24738276
165PRKD10.24608449
166RPS6KA60.21552209

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.16599516
2Osteoclast differentiation_Homo sapiens_hsa043802.98277432
3Measles_Homo sapiens_hsa051622.84382593
4Olfactory transduction_Homo sapiens_hsa047402.83016973
5Synaptic vesicle cycle_Homo sapiens_hsa047212.77567932
6Leishmaniasis_Homo sapiens_hsa051402.76048024
7GABAergic synapse_Homo sapiens_hsa047272.58158046
8Circadian entrainment_Homo sapiens_hsa047132.52184419
9Glutamatergic synapse_Homo sapiens_hsa047242.41153486
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.38833976
11Amphetamine addiction_Homo sapiens_hsa050312.38788746
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.38339071
13Long-term potentiation_Homo sapiens_hsa047202.35211498
14Graft-versus-host disease_Homo sapiens_hsa053322.33773215
15Influenza A_Homo sapiens_hsa051642.33337284
16Morphine addiction_Homo sapiens_hsa050322.32777122
17Staphylococcus aureus infection_Homo sapiens_hsa051502.29888601
18Toll-like receptor signaling pathway_Homo sapiens_hsa046202.29524648
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.28327932
20Allograft rejection_Homo sapiens_hsa053302.20503841
21Primary immunodeficiency_Homo sapiens_hsa053402.13767137
22Autoimmune thyroid disease_Homo sapiens_hsa053202.13595645
23Dopaminergic synapse_Homo sapiens_hsa047282.04854482
24Malaria_Homo sapiens_hsa051442.04269544
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.04137686
26Salivary secretion_Homo sapiens_hsa049702.03238453
27Cocaine addiction_Homo sapiens_hsa050302.00988290
28B cell receptor signaling pathway_Homo sapiens_hsa046622.00227377
29Herpes simplex infection_Homo sapiens_hsa051681.99015980
30Tuberculosis_Homo sapiens_hsa051521.98784654
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97981294
32African trypanosomiasis_Homo sapiens_hsa051431.97484972
33Hepatitis C_Homo sapiens_hsa051601.92980652
34Insulin secretion_Homo sapiens_hsa049111.89024122
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83629513
36Cholinergic synapse_Homo sapiens_hsa047251.83117593
37Gastric acid secretion_Homo sapiens_hsa049711.82858202
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78835362
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75617364
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75034563
41Nitrogen metabolism_Homo sapiens_hsa009101.70116316
42Antigen processing and presentation_Homo sapiens_hsa046121.69022954
43Renin secretion_Homo sapiens_hsa049241.68117042
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66290234
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64124778
46Oxytocin signaling pathway_Homo sapiens_hsa049211.59540178
47Acute myeloid leukemia_Homo sapiens_hsa052211.57928394
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56269847
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54428695
50Long-term depression_Homo sapiens_hsa047301.52262494
51Calcium signaling pathway_Homo sapiens_hsa040201.47322607
52Toxoplasmosis_Homo sapiens_hsa051451.46287790
53Viral myocarditis_Homo sapiens_hsa054161.45019953
54T cell receptor signaling pathway_Homo sapiens_hsa046601.42252829
55Taste transduction_Homo sapiens_hsa047421.42072342
56GnRH signaling pathway_Homo sapiens_hsa049121.41246653
57NF-kappa B signaling pathway_Homo sapiens_hsa040641.40639362
58Serotonergic synapse_Homo sapiens_hsa047261.37671356
59Jak-STAT signaling pathway_Homo sapiens_hsa046301.36984958
60Legionellosis_Homo sapiens_hsa051341.36621272
61Gap junction_Homo sapiens_hsa045401.35766058
62Hepatitis B_Homo sapiens_hsa051611.31208389
63cAMP signaling pathway_Homo sapiens_hsa040241.28485641
64Hematopoietic cell lineage_Homo sapiens_hsa046401.26541714
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25949809
66Estrogen signaling pathway_Homo sapiens_hsa049151.23876353
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22367857
68Dorso-ventral axis formation_Homo sapiens_hsa043201.20778504
69Phagosome_Homo sapiens_hsa041451.20218039
70Type II diabetes mellitus_Homo sapiens_hsa049301.19403625
71TNF signaling pathway_Homo sapiens_hsa046681.19032587
72Axon guidance_Homo sapiens_hsa043601.18200815
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16966824
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14604262
75Melanogenesis_Homo sapiens_hsa049161.14333052
76Glioma_Homo sapiens_hsa052141.12777368
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11855520
78ErbB signaling pathway_Homo sapiens_hsa040121.08172998
79Leukocyte transendothelial migration_Homo sapiens_hsa046701.07731797
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03631688
81Platelet activation_Homo sapiens_hsa046111.02106011
82cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01432402
83Dilated cardiomyopathy_Homo sapiens_hsa054140.96118343
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95798354
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94126036
86Thyroid hormone synthesis_Homo sapiens_hsa049180.91319374
87Pancreatic cancer_Homo sapiens_hsa052120.91243327
88Pertussis_Homo sapiens_hsa051330.90963457
89Prolactin signaling pathway_Homo sapiens_hsa049170.89691253
90Collecting duct acid secretion_Homo sapiens_hsa049660.87411466
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85201183
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.84131677
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.83676318
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82447736
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.81997502
96Cardiac muscle contraction_Homo sapiens_hsa042600.80791977
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80044819
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79821397
99Apoptosis_Homo sapiens_hsa042100.77647745
100Salmonella infection_Homo sapiens_hsa051320.76404504
101Pancreatic secretion_Homo sapiens_hsa049720.75040389
102Chronic myeloid leukemia_Homo sapiens_hsa052200.74428346
103MAPK signaling pathway_Homo sapiens_hsa040100.74274984
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73486321
105Notch signaling pathway_Homo sapiens_hsa043300.72979950
106Shigellosis_Homo sapiens_hsa051310.72444859
107Vibrio cholerae infection_Homo sapiens_hsa051100.71388611
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70589189
109Tight junction_Homo sapiens_hsa045300.70207530
110Rap1 signaling pathway_Homo sapiens_hsa040150.69569384
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68950041
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68297447
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.67030600
114Oocyte meiosis_Homo sapiens_hsa041140.65500435
115Choline metabolism in cancer_Homo sapiens_hsa052310.65348656
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.64836502
117Epstein-Barr virus infection_Homo sapiens_hsa051690.64224630
118Phenylalanine metabolism_Homo sapiens_hsa003600.63105040
119Viral carcinogenesis_Homo sapiens_hsa052030.62618996
120Bile secretion_Homo sapiens_hsa049760.62512228
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62197437
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61888317
123Other glycan degradation_Homo sapiens_hsa005110.60902933
124Renal cell carcinoma_Homo sapiens_hsa052110.60637888
125Wnt signaling pathway_Homo sapiens_hsa043100.60396123
126Ras signaling pathway_Homo sapiens_hsa040140.59402419
127VEGF signaling pathway_Homo sapiens_hsa043700.56195309
128Amoebiasis_Homo sapiens_hsa051460.56084564
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55452263
130Rheumatoid arthritis_Homo sapiens_hsa053230.54209995
131Glucagon signaling pathway_Homo sapiens_hsa049220.53078452
132Alcoholism_Homo sapiens_hsa050340.52864001
133Prion diseases_Homo sapiens_hsa050200.52752633
134Non-small cell lung cancer_Homo sapiens_hsa052230.52222554
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51736073
136FoxO signaling pathway_Homo sapiens_hsa040680.51614405
137Endometrial cancer_Homo sapiens_hsa052130.50807597
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50526064
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49091332
140Inositol phosphate metabolism_Homo sapiens_hsa005620.46583670
141Type I diabetes mellitus_Homo sapiens_hsa049400.46186789
142Asthma_Homo sapiens_hsa053100.45999708
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45423740
144Endocytosis_Homo sapiens_hsa041440.44968936
145Insulin resistance_Homo sapiens_hsa049310.44905780
146HTLV-I infection_Homo sapiens_hsa051660.44836865
147Hippo signaling pathway_Homo sapiens_hsa043900.42805709
148mTOR signaling pathway_Homo sapiens_hsa041500.42142970
149Phototransduction_Homo sapiens_hsa047440.42011805
150Ovarian steroidogenesis_Homo sapiens_hsa049130.42007008
151Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41970096
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41719463
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41417015
154Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40688721
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.40613737
156Sphingolipid signaling pathway_Homo sapiens_hsa040710.40559175
157Insulin signaling pathway_Homo sapiens_hsa049100.40534067
158Chemokine signaling pathway_Homo sapiens_hsa040620.39480281
159Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36821242
160HIF-1 signaling pathway_Homo sapiens_hsa040660.36621618
161Protein digestion and absorption_Homo sapiens_hsa049740.36460005
162Circadian rhythm_Homo sapiens_hsa047100.35034198
163Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34253176
164Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33758022
165Colorectal cancer_Homo sapiens_hsa052100.33728810
166Regulation of autophagy_Homo sapiens_hsa041400.33624830
167Proteoglycans in cancer_Homo sapiens_hsa052050.32596664
168Focal adhesion_Homo sapiens_hsa045100.32456038

Most similar genes based on co-expression Upload to Enrichr

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