OTOP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid transmembrane transport (GO:1902001)9.46236961
2regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)8.88130827
3tricarboxylic acid cycle (GO:0006099)8.63461948
4biotin metabolic process (GO:0006768)8.45306765
5NADH metabolic process (GO:0006734)8.28506140
6regulation of acyl-CoA biosynthetic process (GO:0050812)8.15969712
7regulation of fatty acid oxidation (GO:0046320)7.98595084
8fatty acid beta-oxidation (GO:0006635)7.85651576
9carnitine transmembrane transport (GO:1902603)7.83259895
10regulation of cofactor metabolic process (GO:0051193)7.72993142
11regulation of coenzyme metabolic process (GO:0051196)7.72993142
12positive regulation of fatty acid beta-oxidation (GO:0032000)7.23826044
13positive regulation of fatty acid oxidation (GO:0046321)7.21960034
14carnitine transport (GO:0015879)7.17632046
15amino-acid betaine transport (GO:0015838)7.17632046
16brown fat cell differentiation (GO:0050873)6.90875934
17fatty acid oxidation (GO:0019395)6.54074397
18fatty acid catabolic process (GO:0009062)6.53526944
19lipid oxidation (GO:0034440)6.42816232
20regulation of sulfur metabolic process (GO:0042762)6.22062627
21triglyceride catabolic process (GO:0019433)6.15993191
22white fat cell differentiation (GO:0050872)6.01965639
23acetyl-CoA metabolic process (GO:0006084)5.86415602
24acyl-CoA biosynthetic process (GO:0071616)5.70967412
25thioester biosynthetic process (GO:0035384)5.70967412
26regulation of fatty acid beta-oxidation (GO:0031998)5.68778649
27intracellular lipid transport (GO:0032365)5.67498538
28coenzyme A biosynthetic process (GO:0015937)5.63903202
29lipid particle organization (GO:0034389)5.59803065
30acylglycerol catabolic process (GO:0046464)5.56717526
31neutral lipid catabolic process (GO:0046461)5.56717526
32succinate metabolic process (GO:0006105)5.52772381
33triglyceride biosynthetic process (GO:0019432)5.52478633
34branched-chain amino acid catabolic process (GO:0009083)5.34171703
35lipid storage (GO:0019915)5.33873950
36neutral lipid biosynthetic process (GO:0046460)5.27857112
37acylglycerol biosynthetic process (GO:0046463)5.27857112
38low-density lipoprotein particle clearance (GO:0034383)5.26587017
39quaternary ammonium group transport (GO:0015697)5.23201478
40fatty-acyl-CoA biosynthetic process (GO:0046949)5.01881876
41positive regulation of lipid storage (GO:0010884)5.00520573
42proline transport (GO:0015824)4.97500906
43valine metabolic process (GO:0006573)4.95132074
44monocarboxylic acid catabolic process (GO:0072329)4.92077193
45negative regulation of fatty acid biosynthetic process (GO:0045717)4.86124734
46glycine transport (GO:0015816)4.79245694
47branched-chain amino acid metabolic process (GO:0009081)4.78102456
48tricarboxylic acid metabolic process (GO:0072350)4.71685264
49lysine metabolic process (GO:0006553)4.71151151
50lysine catabolic process (GO:0006554)4.71151151
51regulation of triglyceride catabolic process (GO:0010896)4.70704287
52short-chain fatty acid metabolic process (GO:0046459)4.68760778
53regulation of cholesterol storage (GO:0010885)4.66406320
54alanine transport (GO:0032328)4.65009040
55fatty-acyl-CoA metabolic process (GO:0035337)4.60784314
56carnitine metabolic process (GO:0009437)4.49478044
57cardiolipin metabolic process (GO:0032048)4.45245961
58coenzyme A metabolic process (GO:0015936)4.42092554
59positive regulation of lipid catabolic process (GO:0050996)4.37071078
60negative regulation of fatty acid metabolic process (GO:0045922)4.34475308
61long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.22891527
62regulation of fatty acid metabolic process (GO:0019217)4.18951221
63glycerolipid catabolic process (GO:0046503)4.09977152
64negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.09466546
65long-chain fatty acid transport (GO:0015909)4.07776621
66acyl-CoA metabolic process (GO:0006637)4.03527123
67thioester metabolic process (GO:0035383)4.03527123
68positive regulation of glycolytic process (GO:0045821)3.99813962
69long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.87826247
70regulation of lipid storage (GO:0010883)3.85833052
71triglyceride metabolic process (GO:0006641)3.85225410
72cellular lipid catabolic process (GO:0044242)3.84142372
73positive regulation of fatty acid metabolic process (GO:0045923)3.81965060
74alpha-linolenic acid metabolic process (GO:0036109)3.76246907
75respiratory electron transport chain (GO:0022904)3.75762709
76pentose-phosphate shunt (GO:0006098)3.73875270
77negative regulation of lipid storage (GO:0010888)3.73256812
78electron transport chain (GO:0022900)3.66732683
79acylglycerol metabolic process (GO:0006639)3.64716807
80neutral lipid metabolic process (GO:0006638)3.60109246
81NADPH regeneration (GO:0006740)3.55165793
82temperature homeostasis (GO:0001659)3.52474164
83negative regulation of lipid catabolic process (GO:0050995)3.51771352
84response to phenylpropanoid (GO:0080184)3.51444599
85negative regulation of lipase activity (GO:0060192)3.50540172
86glycerol metabolic process (GO:0006071)3.49760275
87regulation of triglyceride biosynthetic process (GO:0010866)3.47632963
88regulation of lipid catabolic process (GO:0050994)3.46139132
89fatty acid transport (GO:0015908)3.44396534
90CDP-diacylglycerol biosynthetic process (GO:0016024)3.42524613
91purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.39671503
92ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.39671503
93nucleoside bisphosphate biosynthetic process (GO:0033866)3.39671503
94cellular response to lithium ion (GO:0071285)3.38778513
95amino-acid betaine metabolic process (GO:0006577)3.32469857
96positive regulation of triglyceride metabolic process (GO:0090208)3.32364680
97lipid modification (GO:0030258)3.27899624
98phosphatidic acid biosynthetic process (GO:0006654)3.27719243
99regulation of sequestering of triglyceride (GO:0010889)11.6158693
100carnitine shuttle (GO:0006853)10.2450259

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse8.00685453
2CLOCK_20551151_ChIP-Seq_293T_Human3.97544090
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.57195175
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.13102026
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.90757316
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.74920410
7ZNF263_19887448_ChIP-Seq_K562_Human2.60565347
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.47176077
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.44062204
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.39001141
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.28019448
12PPAR_26484153_Chip-Seq_NCI-H1993_Human2.13405168
13PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.10158526
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05407345
15PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.02352556
16ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.00633689
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse15.9724135
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.86191169
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74275004
20PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.68843959
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64122401
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62869065
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.53675004
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48370985
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.42232326
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33356096
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.32766034
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29046878
29* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25909691
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.25549898
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23803238
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23358625
33* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22030193
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.20055540
35TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10385974
36FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07330217
37CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06247808
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.04726383
39TBX20_22328084_ChIP-Seq_HEART_Mouse1.04726383
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.04059362
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02342158
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.00156706
43EGR1_19032775_ChIP-ChIP_M12_Human0.99536717
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98164515
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97408149
46BCAT_22108803_ChIP-Seq_LS180_Human0.96140457
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92838223
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85675338
49CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85378486
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83223505
51CBP_20019798_ChIP-Seq_JUKART_Human0.83223505
52ATF3_27146783_Chip-Seq_COLON_Human0.81836967
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81620838
54SALL1_21062744_ChIP-ChIP_HESCs_Human0.80774536
55* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.80219118
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79403398
57P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79173806
58SOX9_24532713_ChIP-Seq_HFSC_Mouse0.78396663
59RUNX1_27514584_Chip-Seq_MCF-7_Human0.76962144
60GATA1_22025678_ChIP-Seq_K562_Human0.76895227
61GATA3_24758297_ChIP-Seq_MCF-7_Human0.76839147
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.75767421
63* FOXA2_19822575_ChIP-Seq_HepG2_Human0.75478972
64* RXR_22108803_ChIP-Seq_LS180_Human0.75214212
65RACK7_27058665_Chip-Seq_MCF-7_Human0.75193683
66ESR2_21235772_ChIP-Seq_MCF-7_Human0.74371904
67STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73701551
68SOX2_27498859_Chip-Seq_STOMACH_Mouse0.73478608
69NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.73236075
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.72000125
71SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.72000125
72STAT6_21828071_ChIP-Seq_BEAS2B_Human0.70605461
73ERG_20517297_ChIP-Seq_VCAP_Human0.69688686
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.69203997
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.66226116
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.64257952
77CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.63763475
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.63186526
79PIAS1_25552417_ChIP-Seq_VCAP_Human0.62362458
80GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.61167513
81VDR_24787735_ChIP-Seq_THP-1_Human0.59989124
82GATA1_19941826_ChIP-Seq_K562_Human0.58756674
83KLF4_18555785_ChIP-Seq_MESCs_Mouse0.58361213
84AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.58302882
85SOX2_20726797_ChIP-Seq_SW620_Human0.57604513
86ZNF217_24962896_ChIP-Seq_MCF-7_Human0.57104617
87CEBPB_22108803_ChIP-Seq_LS180_Human0.56258699
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.55552392
89P63_26484246_Chip-Seq_KERATINOCYTES_Human0.54462171
90GATA4_25053715_ChIP-Seq_YYC3_Human0.54462048
91KLF4_19829295_ChIP-Seq_ESCs_Human0.54327083
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.51854293
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.51484842
94RUNX_20019798_ChIP-Seq_JUKART_Human0.51012227
95CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.50996734
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.50822895
97* HNF4A_19822575_ChIP-Seq_HepG2_Human0.50136870
98KDM2B_26808549_Chip-Seq_SUP-B15_Human0.49684404
99FOXA1_25552417_ChIP-Seq_VCAP_Human0.48318070
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.48137786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose8.56827740
2MP0005666_abnormal_adipose_tissue6.12007072
3MP0004130_abnormal_muscle_cell5.14471140
4MP0002971_abnormal_brown_adipose5.10383021
5MP0004185_abnormal_adipocyte_glucose5.00246689
6MP0002837_dystrophic_cardiac_calcinosis4.58697692
7MP0005375_adipose_tissue_phenotype4.13620816
8MP0005535_abnormal_body_temperature3.28421571
9MP0003646_muscle_fatigue3.11629476
10MP0000003_abnormal_adipose_tissue2.98156615
11MP0006036_abnormal_mitochondrial_physio2.90042723
12MP0000013_abnormal_adipose_tissue2.88319275
13MP0002970_abnormal_white_adipose2.74319305
14MP0009115_abnormal_fat_cell2.63497083
15MP0010329_abnormal_lipoprotein_level2.30423103
16MP0002118_abnormal_lipid_homeostasis2.30101417
17MP0005334_abnormal_fat_pad2.29970214
18MP0005330_cardiomyopathy1.98072661
19MP0005448_abnormal_energy_balance1.81468719
20MP0002078_abnormal_glucose_homeostasis1.71794281
21MP0005332_abnormal_amino_acid1.62748471
22MP0005452_abnormal_adipose_tissue1.60010295
23MP0008438_abnormal_cutaneous_collagen1.58463569
24MP0008961_abnormal_basal_metabolism1.51829360
25MP0000609_abnormal_liver_physiology1.50113612
26MP0005584_abnormal_enzyme/coenzyme_acti1.49877891
27MP0003221_abnormal_cardiomyocyte_apopto1.39717046
28MP0003959_abnormal_lean_body1.36582416
29MP0002332_abnormal_exercise_endurance1.35187129
30MP0008775_abnormal_heart_ventricle1.29876296
31MP0001661_extended_life_span1.29256559
32MP0005365_abnormal_bile_salt1.20519039
33MP0003724_increased_susceptibility_to1.17674521
34MP0004087_abnormal_muscle_fiber1.17541684
35MP0001881_abnormal_mammary_gland1.14893765
36MP0010234_abnormal_vibrissa_follicle1.12143814
37MP0003690_abnormal_glial_cell1.03900816
38MP0003191_abnormal_cellular_cholesterol1.03206739
39MP0006035_abnormal_mitochondrial_morpho1.00819127
40MP0006138_congestive_heart_failure1.00255952
41MP0003879_abnormal_hair_cell0.99454412
42MP0005385_cardiovascular_system_phenoty0.97201173
43MP0001544_abnormal_cardiovascular_syste0.97201173
44MP0004272_abnormal_basement_membrane0.95929484
45MP0003705_abnormal_hypodermis_morpholog0.95160990
46MP0005275_abnormal_skin_tensile0.92998661
47MP0008872_abnormal_physiological_respon0.92606865
48MP0002877_abnormal_melanocyte_morpholog0.89598471
49MP0003566_abnormal_cell_adhesion0.88919195
50MP0003953_abnormal_hormone_level0.87586545
51MP0010630_abnormal_cardiac_muscle0.84800978
52MP0003948_abnormal_gas_homeostasis0.84678275
53MP0001853_heart_inflammation0.83297545
54MP0001485_abnormal_pinna_reflex0.81429918
55MP0003878_abnormal_ear_physiology0.81147322
56MP0005377_hearing/vestibular/ear_phenot0.81147322
57MP0000759_abnormal_skeletal_muscle0.80946421
58MP0000343_altered_response_to0.76865067
59MP0005319_abnormal_enzyme/_coenzyme0.75945398
60MP0002909_abnormal_adrenal_gland0.75092479
61MP0005076_abnormal_cell_differentiation0.72597599
62MP0004147_increased_porphyrin_level0.71170936
63MP0006054_spinal_hemorrhage0.69980917
64MP0001879_abnormal_lymphatic_vessel0.69809808
65MP0004215_abnormal_myocardial_fiber0.68546268
66MP0003186_abnormal_redox_activity0.68293419
67MP0004233_abnormal_muscle_weight0.67343057
68MP0009643_abnormal_urine_homeostasis0.66941928
69MP0004134_abnormal_chest_morphology0.65466012
70MP0002269_muscular_atrophy0.65086978
71MP0001727_abnormal_embryo_implantation0.64853207
72MP0002876_abnormal_thyroid_physiology0.63421682
73MP0005620_abnormal_muscle_contractility0.63022882
74MP0002972_abnormal_cardiac_muscle0.62498728
75MP0003045_fibrosis0.59748607
76MP0005645_abnormal_hypothalamus_physiol0.58781744
77MP0003950_abnormal_plasma_membrane0.58603446
78MP0002796_impaired_skin_barrier0.57342828
79MP0002139_abnormal_hepatobiliary_system0.55784233
80MP0004043_abnormal_pH_regulation0.54664694
81MP0005266_abnormal_metabolism0.53390826
82MP0004484_altered_response_of0.51954174
83MP0010352_gastrointestinal_tract_polyps0.50133381
84MP0003329_amyloid_beta_deposits0.49597757
85MP0002060_abnormal_skin_morphology0.44987669
86MP0005085_abnormal_gallbladder_physiolo0.43286787
87MP0002106_abnormal_muscle_physiology0.42188780
88MP0004924_abnormal_behavior0.41855862
89MP0005386_behavior/neurological_phenoty0.41855862
90MP0000598_abnormal_liver_morphology0.40942665
91MP0001756_abnormal_urination0.40436185
92MP0000604_amyloidosis0.38879303
93MP0002166_altered_tumor_susceptibility0.38006313
94MP0009642_abnormal_blood_homeostasis0.37582606
95MP0000750_abnormal_muscle_regeneration0.37363733
96MP0003195_calcinosis0.35789921
97MP0000230_abnormal_systemic_arterial0.34235529
98MP0003300_gastrointestinal_ulcer0.33901893
99MP0003633_abnormal_nervous_system0.33574236
100MP0000747_muscle_weakness0.33447432

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)7.56402760
2Myoglobinuria (HP:0002913)6.96748715
3Hypoglycemic coma (HP:0001325)6.69386902
4Abnormality of fatty-acid metabolism (HP:0004359)6.43231370
5Rhabdomyolysis (HP:0003201)6.31773096
6Dicarboxylic aciduria (HP:0003215)6.20005082
7Abnormality of dicarboxylic acid metabolism (HP:0010995)6.20005082
8Abnormality of glycine metabolism (HP:0010895)5.94098180
9Abnormality of serine family amino acid metabolism (HP:0010894)5.94098180
10Hydroxyprolinuria (HP:0003080)5.28411263
11Abnormality of proline metabolism (HP:0010907)5.28411263
12Hepatic necrosis (HP:0002605)5.09997928
13Increased muscle lipid content (HP:0009058)5.02087599
14Renal cortical cysts (HP:0000803)4.56585804
15Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.56241195
16Generalized aminoaciduria (HP:0002909)4.54438893
17Oligomenorrhea (HP:0000876)4.52681903
18Difficulty running (HP:0009046)4.33149199
19Hyperammonemia (HP:0001987)4.27851432
20Ketoacidosis (HP:0001993)4.21179194
21Acanthosis nigricans (HP:0000956)3.99912516
22Limb hypertonia (HP:0002509)3.98212235
23Nausea (HP:0002018)3.88450387
24Ketosis (HP:0001946)3.83960494
25Hyperglycinemia (HP:0002154)3.83211198
26Hypertriglyceridemia (HP:0002155)3.75163308
27Hyperalaninemia (HP:0003348)3.65692147
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.65692147
29Abnormality of alanine metabolism (HP:0010916)3.65692147
30Methylmalonic aciduria (HP:0012120)3.63736712
31Increased serum pyruvate (HP:0003542)3.57483926
32Abnormality of glycolysis (HP:0004366)3.57483926
33Insulin-resistant diabetes mellitus (HP:0000831)3.41881278
34Hepatocellular necrosis (HP:0001404)3.28216864
35Proximal tubulopathy (HP:0000114)3.22678889
36Acute encephalopathy (HP:0006846)3.15570416
37Bone cyst (HP:0012062)3.14508923
38Cerebral edema (HP:0002181)3.13947547
39Conjunctival hamartoma (HP:0100780)3.12202144
40Lactic acidosis (HP:0003128)3.07630527
41Lethargy (HP:0001254)3.06152207
42Pheochromocytoma (HP:0002666)2.95051597
43Abnormal mitochondria in muscle tissue (HP:0008316)2.93170018
44Exercise-induced myalgia (HP:0003738)2.90267285
45Long foot (HP:0001833)2.90148032
46Muscle stiffness (HP:0003552)2.82357258
47Methylmalonic acidemia (HP:0002912)2.80533345
48Increased intramyocellular lipid droplets (HP:0012240)2.75459746
49Neonatal death (HP:0003811)2.73206814
50Esophageal neoplasm (HP:0100751)2.68320097
51Neoplasm of head and neck (HP:0012288)2.68320097
52Abnormality of serum amino acid levels (HP:0003112)2.66779667
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.63223554
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.60856779
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.60856779
56Athetosis (HP:0002305)2.59760989
57Acute necrotizing encephalopathy (HP:0006965)2.59544141
58Neuroendocrine neoplasm (HP:0100634)2.53818616
59Respiratory failure (HP:0002878)2.50571330
60Tachypnea (HP:0002789)2.43424115
61Facial diplegia (HP:0001349)2.42856062
62Increased CSF lactate (HP:0002490)2.42183917
63Large hands (HP:0001176)2.40472820
64Vomiting (HP:0002013)2.40346581
65Hamartoma of the eye (HP:0010568)2.37702768
66Lipid accumulation in hepatocytes (HP:0006561)2.37639614
67Metabolic acidosis (HP:0001942)2.31331761
68Progressive macrocephaly (HP:0004481)2.30289085
69Insulin resistance (HP:0000855)2.26412251
70Growth hormone excess (HP:0000845)2.24149306
71Hypoalphalipoproteinemia (HP:0003233)2.18384887
72Abnormality of the renal cortex (HP:0011035)2.16058519
73Cerebral hemorrhage (HP:0001342)2.12940019
74Palpitations (HP:0001962)2.12921452
75Prenatal maternal abnormality (HP:0002686)2.12695121
76Reduced subcutaneous adipose tissue (HP:0003758)2.10946228
77Pancreatitis (HP:0001733)2.10515726
78Mitochondrial inheritance (HP:0001427)2.06459013
79Tetraparesis (HP:0002273)1.98596494
80Multiple enchondromatosis (HP:0005701)1.98008191
81Dysmetric saccades (HP:0000641)1.90618374
82Neoplasm of the rectum (HP:0100743)1.89959166
83Neonatal hypoglycemia (HP:0001998)1.88840230
84Increased connective tissue (HP:0009025)1.88192078
85Exercise intolerance (HP:0003546)1.82867354
86Neoplasm of the adrenal gland (HP:0100631)1.81244440
87Clitoromegaly (HP:0000057)1.80765459
88Hypoglycemic seizures (HP:0002173)1.80427853
89Epidermoid cyst (HP:0200040)1.77989108
90Respiratory distress (HP:0002098)1.77542899
91Neoplasm of the small intestine (HP:0100833)1.74736836
92Neoplasm of the peripheral nervous system (HP:0100007)1.74129745
93Hyperglycemia (HP:0003074)1.72973975
94Increased serum lactate (HP:0002151)1.70815524
95Toxemia of pregnancy (HP:0100603)1.68362268
96Abnormal cartilage morphology (HP:0002763)1.67732246
97Adenoma sebaceum (HP:0009720)1.66287024
98Angiofibromas (HP:0010615)1.66287024
99Acute hepatic failure (HP:0006554)1.64545625
100Gliosis (HP:0002171)1.63307913

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.30766477
2PDK35.90152552
3PDK45.90152552
4CAMK1D5.65359745
5TRIB35.55030218
6CAMK1G3.94386418
7PDK23.66460181
8SIK12.94148643
9PRKAA22.06996830
10PKN22.03395242
11LATS11.48909212
12CDK91.36943629
13RIPK11.31242549
14PDPK11.30349397
15CDK61.27442904
16PRKD31.27144962
17INSRR1.21545610
18PDK11.14921486
19PRKAA11.09176297
20MAP2K11.02160920
21PDGFRA0.99883028
22FRK0.87198446
23MST1R0.85237584
24LMTK20.84939243
25FGFR30.84718627
26NEK10.82676099
27TIE10.74612224
28STK30.74370453
29LATS20.72968086
30CDK40.72407631
31TGFBR20.72331850
32PRKCH0.71176531
33PRKACG0.70154578
34ILK0.66122016
35MTOR0.65702261
36FLT30.64658512
37FGFR20.60505616
38FGFR40.59416937
39JAK10.57115507
40FER0.55630027
41RET0.55141335
42KSR20.52772226
43MAP3K60.51721785
44NEK90.50983256
45EPHA20.50228283
46ERN10.49875741
47PINK10.49044623
48MAPK110.48674271
49JAK20.48615863
50PRKD10.47902883
51AKT20.46972974
52GSK3A0.46367847
53EIF2AK20.43723047
54PTK60.42826655
55ICK0.39916783
56STK38L0.39546669
57IRAK30.38673766
58MAP3K20.38641350
59MET0.34650454
60DYRK1B0.33451224
61SCYL20.33206717
62PRKD20.32953486
63IGF1R0.32905582
64INSR0.32815807
65TRPM70.32482271
66STK110.31806066
67SGK30.30388077
68BMX0.30299632
69BCR0.29738357
70FGFR10.28627413
71PDGFRB0.28566092
72TTK0.27856581
73EPHB20.27374296
74CAMK10.27256021
75RPS6KB10.25980860
76DDR20.25342202
77AKT10.24731723
78EPHB10.24439202
79NTRK30.24193070
80ABL20.23641951
81PHKG20.22328672
82PHKG10.22328672
83TTN0.21673950
84LRRK20.20327715
85EEF2K0.20234305
86PAK60.20114020
87PRKCE0.19924864
88EPHA30.19251054
89IRAK10.18798500
90RPS6KA30.18288272
91SGK4940.18023157
92SGK2230.18023157
93CSNK1G10.16764109
94DYRK20.16748541
95CDK50.16719391
96RPS6KA10.15923894
97SRC0.15528166
98MAPK80.10685406
99PIK3CA0.10682171
100PRKACA0.10152992

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.57513096
2Propanoate metabolism_Homo sapiens_hsa006405.73519810
3Fatty acid metabolism_Homo sapiens_hsa012124.64765413
4Fatty acid degradation_Homo sapiens_hsa000714.54466228
5Fatty acid biosynthesis_Homo sapiens_hsa000614.02954752
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002804.02467338
7PPAR signaling pathway_Homo sapiens_hsa033203.60526352
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.31571897
9Fatty acid elongation_Homo sapiens_hsa000622.85248498
10Pyruvate metabolism_Homo sapiens_hsa006202.77630187
11Carbon metabolism_Homo sapiens_hsa012002.69334909
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66875304
13Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.25311216
14Butanoate metabolism_Homo sapiens_hsa006501.89545565
15Glycerolipid metabolism_Homo sapiens_hsa005611.65112127
16beta-Alanine metabolism_Homo sapiens_hsa004101.58639274
17Adipocytokine signaling pathway_Homo sapiens_hsa049201.54198856
18AMPK signaling pathway_Homo sapiens_hsa041521.39469649
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28363321
20Peroxisome_Homo sapiens_hsa041461.21371652
21Glucagon signaling pathway_Homo sapiens_hsa049221.21012391
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19441652
23Tryptophan metabolism_Homo sapiens_hsa003801.11512795
24Insulin resistance_Homo sapiens_hsa049311.06149424
25Parkinsons disease_Homo sapiens_hsa050121.05187832
26Oxidative phosphorylation_Homo sapiens_hsa001901.05169100
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02134664
28Insulin signaling pathway_Homo sapiens_hsa049101.01388466
29Lysine degradation_Homo sapiens_hsa003100.91544080
30Huntingtons disease_Homo sapiens_hsa050160.83921495
31Fat digestion and absorption_Homo sapiens_hsa049750.78416168
32Alzheimers disease_Homo sapiens_hsa050100.77903146
33Biosynthesis of amino acids_Homo sapiens_hsa012300.77750336
34Glycerophospholipid metabolism_Homo sapiens_hsa005640.75410685
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69472038
36Pentose phosphate pathway_Homo sapiens_hsa000300.64524274
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59420144
38Central carbon metabolism in cancer_Homo sapiens_hsa052300.58676648
39Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55707467
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55681227
41Sulfur metabolism_Homo sapiens_hsa009200.52134207
42Nitrogen metabolism_Homo sapiens_hsa009100.50034920
43Caffeine metabolism_Homo sapiens_hsa002320.49296631
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45534808
45Vitamin B6 metabolism_Homo sapiens_hsa007500.42980353
46Starch and sucrose metabolism_Homo sapiens_hsa005000.38430510
47HIF-1 signaling pathway_Homo sapiens_hsa040660.32848994
48Cardiac muscle contraction_Homo sapiens_hsa042600.32584323
49Metabolic pathways_Homo sapiens_hsa011000.32486488
50Renin secretion_Homo sapiens_hsa049240.30683183
51Fructose and mannose metabolism_Homo sapiens_hsa000510.28837690
52Phenylalanine metabolism_Homo sapiens_hsa003600.27560552
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23844808
54Galactose metabolism_Homo sapiens_hsa000520.22974585
55Thyroid cancer_Homo sapiens_hsa052160.22030973
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20088252
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.19448047
58mTOR signaling pathway_Homo sapiens_hsa041500.19028375
59Type II diabetes mellitus_Homo sapiens_hsa049300.18370750
60ECM-receptor interaction_Homo sapiens_hsa045120.17326397
61Tyrosine metabolism_Homo sapiens_hsa003500.15062802
62Small cell lung cancer_Homo sapiens_hsa052220.13002844
63ABC transporters_Homo sapiens_hsa020100.09434536
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.09423726
65Acute myeloid leukemia_Homo sapiens_hsa052210.06422313
66Salivary secretion_Homo sapiens_hsa049700.05754528
67FoxO signaling pathway_Homo sapiens_hsa040680.05108608
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.05014223
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.04852410
70Focal adhesion_Homo sapiens_hsa045100.03500556
71Ovarian steroidogenesis_Homo sapiens_hsa049130.03481846
72Renal cell carcinoma_Homo sapiens_hsa052110.00913748
73Choline metabolism in cancer_Homo sapiens_hsa05231-0.1034040
74Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.1021898
75Toxoplasmosis_Homo sapiens_hsa05145-0.1008101
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261-0.1000035
77Glutathione metabolism_Homo sapiens_hsa00480-0.0985273
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0942676
79Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0833069
80Thyroid hormone signaling pathway_Homo sapiens_hsa04919-0.0804621
81Chronic myeloid leukemia_Homo sapiens_hsa05220-0.0795684
82Viral myocarditis_Homo sapiens_hsa05416-0.0766508
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933-0.0764118
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0751141
85Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0725745
86Tight junction_Homo sapiens_hsa04530-0.0723042
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914-0.0709351
88PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0698216
89Bile secretion_Homo sapiens_hsa04976-0.0667425
90Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0622617
91Proteoglycans in cancer_Homo sapiens_hsa05205-0.0604257
92Amoebiasis_Homo sapiens_hsa05146-0.0579186
93cAMP signaling pathway_Homo sapiens_hsa04024-0.0527682
94Renin-angiotensin system_Homo sapiens_hsa04614-0.0509049
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0497111
96Estrogen signaling pathway_Homo sapiens_hsa04915-0.0405295
97Adherens junction_Homo sapiens_hsa04520-0.0334434
98Platelet activation_Homo sapiens_hsa04611-0.0226110
99Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0201892
100Protein digestion and absorption_Homo sapiens_hsa04974-0.0179181

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