OTOP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)8.96039106
2cell wall macromolecule metabolic process (GO:0044036)8.96039106
3protein-chromophore linkage (GO:0018298)8.92523829
4desmosome organization (GO:0002934)8.80380403
5sulfate transmembrane transport (GO:1902358)7.58479740
6intermediate filament organization (GO:0045109)7.52952610
7keratinization (GO:0031424)7.20170886
8sulfate transport (GO:0008272)6.58235469
9positive regulation of respiratory burst (GO:0060267)6.50255039
10regulation of guanylate cyclase activity (GO:0031282)6.34875555
11receptor recycling (GO:0001881)6.18267857
12adhesion of symbiont to host cell (GO:0044650)6.14036320
13virion attachment to host cell (GO:0019062)6.14036320
14sperm motility (GO:0030317)6.10329977
15positive regulation of synaptic transmission, GABAergic (GO:0032230)6.02639592
16bicarbonate transport (GO:0015701)5.94434065
17glomerular filtration (GO:0003094)5.60567153
18phosphorylated carbohydrate dephosphorylation (GO:0046838)5.47673046
19inositol phosphate dephosphorylation (GO:0046855)5.47673046
20transcytosis (GO:0045056)5.30655497
21bundle of His cell to Purkinje myocyte communication (GO:0086069)5.25788239
22acrosome reaction (GO:0007340)5.21750588
23intestinal absorption (GO:0050892)5.11299710
24renal filtration (GO:0097205)5.07827519
25adhesion of symbiont to host (GO:0044406)5.01386409
26piRNA metabolic process (GO:0034587)4.98059461
27early endosome to late endosome transport (GO:0045022)4.96941022
28cullin deneddylation (GO:0010388)4.96842899
29peptide cross-linking (GO:0018149)4.95457228
30positive regulation of guanylate cyclase activity (GO:0031284)4.93477778
31proline transport (GO:0015824)4.87265546
32synaptonemal complex assembly (GO:0007130)4.80293087
33citrulline biosynthetic process (GO:0019240)4.77156694
34platelet dense granule organization (GO:0060155)4.75593171
35DNA methylation involved in gamete generation (GO:0043046)4.75255174
36synaptonemal complex organization (GO:0070193)4.71398819
37inositol phosphate catabolic process (GO:0071545)4.70464955
38endosome organization (GO:0007032)4.63441702
39inositol metabolic process (GO:0006020)4.54403488
40fusion of sperm to egg plasma membrane (GO:0007342)4.47888297
41one-carbon metabolic process (GO:0006730)4.45649856
42protein localization to Golgi apparatus (GO:0034067)4.43463869
43protein deneddylation (GO:0000338)4.36901367
44purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.31601798
453-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.31601798
46regulation of vesicle fusion (GO:0031338)4.28411498
47acrosome assembly (GO:0001675)4.20810225
48regulation of respiratory burst (GO:0060263)4.19930960
49artery development (GO:0060840)4.14045349
50calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.09504505
51positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.08650678
52mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.08650678
53intermediate filament cytoskeleton organization (GO:0045104)4.08278601
54phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.06905864
55regulation of systemic arterial blood pressure by hormone (GO:0001990)4.06695724
56regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.06695724
57endocrine process (GO:0050886)4.06695724
58retinol metabolic process (GO:0042572)4.03695884
59response to misfolded protein (GO:0051788)4.02805467
60hemidesmosome assembly (GO:0031581)4.00871745
61sulfur compound transport (GO:0072348)3.99066450
62positive regulation of meiotic cell cycle (GO:0051446)3.97087181
63cellular ketone body metabolic process (GO:0046950)3.93644220
64oligosaccharide biosynthetic process (GO:0009312)3.92981663
65keratinocyte differentiation (GO:0030216)3.92355870
66intermediate filament-based process (GO:0045103)3.89483317
67bile acid and bile salt transport (GO:0015721)3.86391208
68spermatid development (GO:0007286)3.83772757
69ethanol oxidation (GO:0006069)3.81057673
70negative regulation of exocytosis (GO:0045920)3.80309491
71male meiosis (GO:0007140)3.78756612
72regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.77783347
73negative regulation of inclusion body assembly (GO:0090084)3.76682528
74nucleoside diphosphate biosynthetic process (GO:0009133)3.76092872
75drug transmembrane transport (GO:0006855)3.73313722
76hair follicle morphogenesis (GO:0031069)3.71339484
77regulation of cGMP biosynthetic process (GO:0030826)3.70919302
78positive regulation of mitochondrial membrane permeability (GO:0035794)3.68733546
79renal system process involved in regulation of blood volume (GO:0001977)3.67601362
80sperm-egg recognition (GO:0035036)3.67238188
81glucocorticoid biosynthetic process (GO:0006704)3.66650791
82photoreceptor cell maintenance (GO:0045494)3.64169531
83cellular response to pH (GO:0071467)3.63274040
84L-ascorbic acid metabolic process (GO:0019852)3.62515443
85epidermis development (GO:0008544)3.61905653
86plasma membrane fusion (GO:0045026)3.59792370
87excretion (GO:0007588)3.58923569
88cellular glucuronidation (GO:0052695)3.58693809
89regulation of sequestering of triglyceride (GO:0010889)3.58096624
90flavonoid metabolic process (GO:0009812)3.57426939
91positive regulation of fatty acid beta-oxidation (GO:0032000)3.56032598
92sodium ion homeostasis (GO:0055078)3.55846260
93regulation of vitamin metabolic process (GO:0030656)3.53755616
94locomotory exploration behavior (GO:0035641)3.49467115
95positive regulation of dendritic spine morphogenesis (GO:0061003)3.48154148
96regulation of water loss via skin (GO:0033561)3.47536964
97establishment of skin barrier (GO:0061436)3.46764893
98regulation of systemic arterial blood pressure (GO:0003073)3.44879053
99ketone body metabolic process (GO:1902224)3.43627979
100cytoskeletal anchoring at plasma membrane (GO:0007016)3.41671231
101receptor guanylyl cyclase signaling pathway (GO:0007168)3.39181486
102cell-cell recognition (GO:0009988)3.38819693
103positive regulation of meiosis (GO:0045836)3.38662396
104negative regulation of cell fate specification (GO:0009996)3.38333354
105binding of sperm to zona pellucida (GO:0007339)3.36734868
106synaptic vesicle maturation (GO:0016188)3.34661805
107microtubule depolymerization (GO:0007019)3.34647609
108uronic acid metabolic process (GO:0006063)3.34493072
109glucuronate metabolic process (GO:0019585)3.34493072
110phosphatidylinositol phosphorylation (GO:0046854)3.34486840
111primary alcohol metabolic process (GO:0034308)3.34384058
112alanine transport (GO:0032328)3.30911937
113ADP metabolic process (GO:0046031)3.27944048
114drug transport (GO:0015893)3.27753618
115polyol biosynthetic process (GO:0046173)3.26852661
116regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.26116697
117thyroid gland development (GO:0030878)3.23418668
118regulation of prostaglandin secretion (GO:0032306)3.20472515
119protein polyglutamylation (GO:0018095)3.20323138
120ethanol metabolic process (GO:0006067)3.17986869
121oocyte development (GO:0048599)3.16754176
122skin morphogenesis (GO:0043589)3.15751787
123motile cilium assembly (GO:0044458)3.12702870
124response to acidic pH (GO:0010447)3.11431872
125regulation of inclusion body assembly (GO:0090083)3.10278416
126positive regulation of male gonad development (GO:2000020)3.09968190
127epidermal cell differentiation (GO:0009913)3.09314978
128calcium ion-dependent exocytosis (GO:0017156)3.06257368
129positive regulation of fatty acid oxidation (GO:0046321)3.04297535
130polyol catabolic process (GO:0046174)3.04173478
131spermatogenesis (GO:0007283)3.02106094
132omega-hydroxylase P450 pathway (GO:0097267)3.02092503
133multicellular organism reproduction (GO:0032504)3.01622449
134reproduction (GO:0000003)3.01159752
135sulfur amino acid catabolic process (GO:0000098)3.00124780
136male gamete generation (GO:0048232)2.99976010
137sexual reproduction (GO:0019953)2.99540314
138regulation of cGMP metabolic process (GO:0030823)2.99539281
139actin filament depolymerization (GO:0030042)2.96342403
140negative regulation of protein tyrosine kinase activity (GO:0061099)2.94916799
141histone H2A ubiquitination (GO:0033522)2.93925193
142regulation of heart rate by cardiac conduction (GO:0086091)2.93296297
143cellular sodium ion homeostasis (GO:0006883)2.90353734
144regulation of male gonad development (GO:2000018)2.89576802
145rhodopsin mediated signaling pathway (GO:0016056)2.86069156
146citrulline metabolic process (GO:0000052)2.85592728
147sperm capacitation (GO:0048240)2.82711701
148vocalization behavior (GO:0071625)2.78543611
149gamete generation (GO:0007276)2.78288194
150regulation of meiosis I (GO:0060631)2.77131146
151cardiac conduction (GO:0061337)2.76647493
152regulation of cardioblast differentiation (GO:0051890)2.75644470
153fat-soluble vitamin biosynthetic process (GO:0042362)2.74819127
154epithelial cilium movement (GO:0003351)2.74682239
155spermatid nucleus differentiation (GO:0007289)2.74212844
156axonemal dynein complex assembly (GO:0070286)2.72574451
157cell communication involved in cardiac conduction (GO:0086065)2.71344693
158lymph vessel development (GO:0001945)2.68846709
159hair cycle process (GO:0022405)2.67913551
160molting cycle process (GO:0022404)2.67913551
161male meiosis I (GO:0007141)2.67719514
162negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.67038219
163interferon-gamma secretion (GO:0072643)2.66826367
164transepithelial transport (GO:0070633)2.64397176
165germ cell development (GO:0007281)2.63807919
166ventricular cardiac muscle cell action potential (GO:0086005)2.62232053
167cellular potassium ion homeostasis (GO:0030007)2.61087970
168regulation of short-term neuronal synaptic plasticity (GO:0048172)2.58727579
169organic cation transport (GO:0015695)2.56087861
170cellular process involved in reproduction in multicellular organism (GO:0022412)2.55336955
171protein targeting to Golgi (GO:0000042)2.52641882
172vitamin transmembrane transport (GO:0035461)2.49598561
173chromosome organization involved in meiosis (GO:0070192)2.48500048
174negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.46374167
175polyol transport (GO:0015791)2.46361204
176chemosensory behavior (GO:0007635)2.45897325
177regulation of cilium movement (GO:0003352)2.44044357
178secondary heart field specification (GO:0003139)2.41972683
179heart field specification (GO:0003128)2.41972683
180regulation of somitogenesis (GO:0014807)2.40107974
181retrograde transport, vesicle recycling within Golgi (GO:0000301)2.37490602
182dendritic spine morphogenesis (GO:0060997)2.35126364
183G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.34693605
184negative regulation of cell fate commitment (GO:0010454)2.34360094
185establishment of protein localization to Golgi (GO:0072600)2.33579790
186molting cycle (GO:0042303)16.7764737
187hair cycle (GO:0042633)16.7764737

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.23505946
2CDX2_20551321_ChIP-Seq_CACO-2_Human3.95885142
3EZH2_22144423_ChIP-Seq_EOC_Human3.32510596
4IGF1R_20145208_ChIP-Seq_DFB_Human3.13925042
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.65374421
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.37671072
7SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05246270
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.03775097
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89935201
10GATA4_25053715_ChIP-Seq_YYC3_Human1.87463870
11GATA6_25053715_ChIP-Seq_YYC3_Human1.84475581
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79977464
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71672555
14JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69575434
15JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67180569
16PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.67110756
17EZH2_27294783_Chip-Seq_ESCs_Mouse1.66483255
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65980393
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65257619
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62614395
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62614395
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62070667
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.61635926
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61370317
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.58325487
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56046432
27PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.56044780
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.54120814
29ELK4_26923725_Chip-Seq_MESODERM_Mouse1.52313137
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51620303
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.51298570
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50350274
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50296425
34CTCF_27219007_Chip-Seq_Bcells_Human1.48555985
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48372996
36ERA_21632823_ChIP-Seq_H3396_Human1.48059830
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45290105
38EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.44846904
39CEBPB_22108803_ChIP-Seq_LS180_Human1.43384994
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42953744
41P63_26484246_Chip-Seq_KERATINOCYTES_Human1.42362923
42SOX2_19829295_ChIP-Seq_ESCs_Human1.33934278
43NANOG_19829295_ChIP-Seq_ESCs_Human1.33934278
44CTCF_20526341_ChIP-Seq_ESCs_Human1.32815256
45CDX2_22108803_ChIP-Seq_LS180_Human1.31212401
46OCT4_20526341_ChIP-Seq_ESCs_Human1.29971277
47PRDM14_20953172_ChIP-Seq_ESCs_Human1.29348572
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27712571
49DROSHA_22980978_ChIP-Seq_HELA_Human1.27607433
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26706235
51CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26500347
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26339980
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.25493808
54ER_23166858_ChIP-Seq_MCF-7_Human1.25066007
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24096722
56VDR_22108803_ChIP-Seq_LS180_Human1.23347716
57MYC_19829295_ChIP-Seq_ESCs_Human1.22865779
58STAT1_20625510_ChIP-Seq_HELA_Human1.21954590
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.21878136
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.20652482
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20123911
62RNF2_27304074_Chip-Seq_NSC_Mouse1.19742572
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.19048109
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17882731
65FOXA1_25552417_ChIP-Seq_VCAP_Human1.17529995
66AR_21572438_ChIP-Seq_LNCaP_Human1.17228631
67FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17003943
68P300_27268052_Chip-Seq_Bcells_Human1.16871613
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.16660711
70TAF2_19829295_ChIP-Seq_ESCs_Human1.16050287
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.15178466
72AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14973011
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14938200
74SOX2_20726797_ChIP-Seq_SW620_Human1.14504215
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14213193
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14175899
77AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14021721
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.14006121
79NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.13981187
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.13881242
81* REST_21632747_ChIP-Seq_MESCs_Mouse1.13719995
82* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.13412345
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10825385
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09188464
85TCF4_18268006_ChIP-ChIP_LS174T_Human1.08074847
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.07530165
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07053945
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05526309
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05525017
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05236028
91NANOG_20526341_ChIP-Seq_ESCs_Human1.03745699
92SPI1_20517297_ChIP-Seq_HL60_Human1.03353418
93SMAD3_21741376_ChIP-Seq_ESCs_Human1.01598921
94GATA3_21867929_ChIP-Seq_TH1_Mouse1.01423552
95TP53_18474530_ChIP-ChIP_U2OS_Human1.01288818
96ZNF263_19887448_ChIP-Seq_K562_Human1.00864651
97FUS_26573619_Chip-Seq_HEK293_Human0.99440872
98EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99434921
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98962706
100E2F1_20622854_ChIP-Seq_HELA_Human0.98928388
101SMC4_20622854_ChIP-Seq_HELA_Human0.97035127
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97010254
103YY1_22570637_ChIP-Seq_MALME-3M_Human0.96585698
104PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96490382
105ELF5_23300383_ChIP-Seq_T47D_Human0.96426689
106* TP63_22573176_ChIP-Seq_HFKS_Human0.96383650
107RARB_27405468_Chip-Seq_BRAIN_Mouse0.96063705
108RUNX2_22187159_ChIP-Seq_PCA_Human0.95781595
109GF1_26923725_Chip-Seq_HPCs_Mouse0.95687076
110PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95571689
111ERG_20517297_ChIP-Seq_VCAP_Human0.95517726
112KDM2B_26808549_Chip-Seq_REH_Human0.94835029
113KLF5_25053715_ChIP-Seq_YYC3_Human0.94018954
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93588997
115FOXH1_21741376_ChIP-Seq_ESCs_Human0.93135585
116P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.92897703
117TP53_20018659_ChIP-ChIP_R1E_Mouse0.92844220
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.92800257
119STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92395329
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91594307
121SA1_27219007_Chip-Seq_Bcells_Human0.91438590
122AHR_22903824_ChIP-Seq_MCF-7_Human0.91088124
123HTT_18923047_ChIP-ChIP_STHdh_Human0.91080325
124AR_25329375_ChIP-Seq_VCAP_Human0.91065914
125POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90826247
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90089683
127HNF4A_19822575_ChIP-Seq_HepG2_Human0.89372151
128SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89284952
129P53_21459846_ChIP-Seq_SAOS-2_Human0.89224798
130FOXA1_25329375_ChIP-Seq_VCAP_Human0.88759364
131FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88759364
132RUNX1_27514584_Chip-Seq_MCF-7_Human0.88681232
133LXR_22292898_ChIP-Seq_THP-1_Human0.88187677
134TET1_21490601_ChIP-Seq_MESCs_Mouse0.87870324
135CSB_26484114_Chip-Seq_FIBROBLAST_Human0.87688376
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.87610725
137KLF4_19829295_ChIP-Seq_ESCs_Human0.87482083
138WDR5_24793694_ChIP-Seq_LNCAP_Human0.87319919
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87111424
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.86727401
141PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86212016
142STAT1_17558387_ChIP-Seq_HELA_Human0.86145938
143GATA1_19941826_ChIP-Seq_K562_Human0.86046662
144JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.85677388
145TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85024723
146POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85024723
147SOX2_21211035_ChIP-Seq_LN229_Human0.84816849
148CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84806683
149TP63_23658742_ChIP-Seq_EP156T_Human0.84373145
150BCL6_27268052_Chip-Seq_Bcells_Human0.84263121
151MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.84003919
152RAD21_21589869_ChIP-Seq_MESCs_Mouse0.83684966
153RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83114327
154TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82435233
155CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82230003
156WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82116739
157REST_18959480_ChIP-ChIP_MESCs_Mouse0.82037793
158RAC3_21632823_ChIP-Seq_H3396_Human0.81430622
159SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80832659
160BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.80662150
161RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80378447
162MYC_27129775_Chip-Seq_CORNEA_Mouse0.79435834
163JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79270591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract7.99672526
2MP0003011_delayed_dark_adaptation7.72591031
3MP0010234_abnormal_vibrissa_follicle6.38641438
4MP0005085_abnormal_gallbladder_physiolo5.61866999
5MP0000579_abnormal_nail_morphology5.45534086
6MP0002796_impaired_skin_barrier5.19636420
7MP0005365_abnormal_bile_salt4.82226880
8MP0005410_abnormal_fertilization4.75018509
9MP0002638_abnormal_pupillary_reflex4.60557706
10MP0002098_abnormal_vibrissa_morphology4.58734284
11MP0000647_abnormal_sebaceous_gland4.50428433
12MP0005084_abnormal_gallbladder_morpholo3.96177499
13MP0000383_abnormal_hair_follicle3.77571326
14MP0002139_abnormal_hepatobiliary_system3.71521623
15MP0010678_abnormal_skin_adnexa3.63550034
16MP0005275_abnormal_skin_tensile3.45184285
17MP0003705_abnormal_hypodermis_morpholog3.14792746
18MP0005501_abnormal_skin_physiology3.11292802
19MP0000427_abnormal_hair_cycle2.89238864
20MP0002138_abnormal_hepatobiliary_system2.84011019
21MP0000377_abnormal_hair_follicle2.83169105
22MP0001764_abnormal_homeostasis2.65967082
23MP0005670_abnormal_white_adipose2.32246206
24MP0009379_abnormal_foot_pigmentation2.16211131
25MP0001765_abnormal_ion_homeostasis2.15563568
26MP0003183_abnormal_peptide_metabolism2.14117099
27MP0001216_abnormal_epidermal_layer2.09561490
28MP0003868_abnormal_feces_composition2.04426540
29MP0004859_abnormal_synaptic_plasticity2.00912203
30MP0001664_abnormal_digestion1.97642148
31MP0002234_abnormal_pharynx_morphology1.97274315
32MP0010771_integument_phenotype1.96081236
33MP0002254_reproductive_system_inflammat1.93312612
34MP0004381_abnormal_hair_follicle1.92551595
35MP0004510_myositis1.90689194
36MP0002928_abnormal_bile_duct1.88117846
37MP0003698_abnormal_male_reproductive1.81311501
38MP0004947_skin_inflammation1.81205336
39MP0000467_abnormal_esophagus_morphology1.79101327
40MP0005379_endocrine/exocrine_gland_phen1.79066608
41MP0005645_abnormal_hypothalamus_physiol1.78972845
42MP0005253_abnormal_eye_physiology1.62619096
43MP0008877_abnormal_DNA_methylation1.59165319
44MP0006082_CNS_inflammation1.58782137
45MP0003453_abnormal_keratinocyte_physiol1.57441931
46MP0001243_abnormal_dermal_layer1.54184397
47MP0002060_abnormal_skin_morphology1.53702520
48MP0001663_abnormal_digestive_system1.51960274
49MP0000566_synostosis1.51193764
50MP0003878_abnormal_ear_physiology1.51015134
51MP0005377_hearing/vestibular/ear_phenot1.51015134
52MP0000537_abnormal_urethra_morphology1.50834129
53MP0006054_spinal_hemorrhage1.48717748
54MP0001929_abnormal_gametogenesis1.47192698
55MP0000762_abnormal_tongue_morphology1.46468034
56MP0003941_abnormal_skin_development1.40439001
57MP0000678_abnormal_parathyroid_gland1.39412012
58MP0002822_catalepsy1.37718153
59MP0004264_abnormal_extraembryonic_tissu1.37629449
60MP0000490_abnormal_crypts_of1.36861961
61MP0000367_abnormal_coat/_hair1.35670132
62MP0004270_analgesia1.33158882
63MP0003693_abnormal_embryo_hatching1.31573823
64MP0000230_abnormal_systemic_arterial1.30651558
65MP0005623_abnormal_meninges_morphology1.29066160
66MP0005636_abnormal_mineral_homeostasis1.25492625
67MP0001502_abnormal_circadian_rhythm1.23174909
68MP0005381_digestive/alimentary_phenotyp1.22324830
69MP0004885_abnormal_endolymph1.16213243
70MP0000477_abnormal_intestine_morphology1.16047959
71MP0001191_abnormal_skin_condition1.14823925
72MP0003566_abnormal_cell_adhesion1.13733859
73MP0006072_abnormal_retinal_apoptosis1.13062237
74MP0005310_abnormal_salivary_gland1.10248760
75MP0003943_abnormal_hepatobiliary_system1.09383591
76MP0002210_abnormal_sex_determination1.08140410
77MP0001727_abnormal_embryo_implantation1.04193385
78MP0010155_abnormal_intestine_physiology1.01838126
79MP0005409_darkened_coat_color1.01475877
80MP0003315_abnormal_perineum_morphology0.99661078
81MP0010386_abnormal_urinary_bladder0.99582451
82MP0005595_abnormal_vascular_smooth0.98353652
83MP0003635_abnormal_synaptic_transmissio0.98162801
84MP0009046_muscle_twitch0.96991711
85MP0002161_abnormal_fertility/fecundity0.96835171
86MP0004742_abnormal_vestibular_system0.96608007
87MP0010352_gastrointestinal_tract_polyps0.95860627
88MP0009931_abnormal_skin_appearance0.94299218
89MP0009780_abnormal_chondrocyte_physiolo0.94110812
90MP0002102_abnormal_ear_morphology0.93830625
91MP0003252_abnormal_bile_duct0.93540947
92MP0005666_abnormal_adipose_tissue0.90906100
93MP0003329_amyloid_beta_deposits0.90026117
94MP0003866_abnormal_defecation0.88835415
95MP0001145_abnormal_male_reproductive0.88700280
96MP0002249_abnormal_larynx_morphology0.86016333
97MP0003879_abnormal_hair_cell0.85515427
98MP0000465_gastrointestinal_hemorrhage0.84439030
99MP0005551_abnormal_eye_electrophysiolog0.83689400
100MP0009053_abnormal_anal_canal0.83146193
101MP0001188_hyperpigmentation0.81415344
102MP0001905_abnormal_dopamine_level0.80372578
103MP0000516_abnormal_urinary_system0.79549428
104MP0005367_renal/urinary_system_phenotyp0.79549428
105MP0004782_abnormal_surfactant_physiolog0.76492567
106MP0002090_abnormal_vision0.75587259
107MP0000653_abnormal_sex_gland0.73696158
108MP0002132_abnormal_respiratory_system0.73153833
109MP0002932_abnormal_joint_morphology0.73130887
110MP0008961_abnormal_basal_metabolism0.71086969
111MP0001873_stomach_inflammation0.70640522
112MP0000538_abnormal_urinary_bladder0.69880293
113MP0005167_abnormal_blood-brain_barrier0.69123251
114MP0004185_abnormal_adipocyte_glucose0.68330652
115MP0003123_paternal_imprinting0.67613317
116MP0000470_abnormal_stomach_morphology0.66854596
117MP0002118_abnormal_lipid_homeostasis0.66665245
118MP0009643_abnormal_urine_homeostasis0.66186158
119MP0003115_abnormal_respiratory_system0.65762460
120MP0000462_abnormal_digestive_system0.64300161
121MP0004019_abnormal_vitamin_homeostasis0.63359149
122MP0003787_abnormal_imprinting0.63242968
123MP0002063_abnormal_learning/memory/cond0.63048758
124MP0009384_cardiac_valve_regurgitation0.62584664
125MP0005451_abnormal_body_composition0.62034177
126MP0001346_abnormal_lacrimal_gland0.61500931
127MP0000627_abnormal_mammary_gland0.61092699
128MP0006138_congestive_heart_failure0.60463258
129MP0008569_lethality_at_weaning0.59991589
130MP0009745_abnormal_behavioral_response0.58598476
131MP0002136_abnormal_kidney_physiology0.57939395
132MP0004484_altered_response_of0.57479567
133MP0005220_abnormal_exocrine_pancreas0.55952167
134MP0002971_abnormal_brown_adipose0.54797114
135MP0002736_abnormal_nociception_after0.54708105
136MP0002282_abnormal_trachea_morphology0.53792244
137MP0003936_abnormal_reproductive_system0.52213171
138MP0002160_abnormal_reproductive_system0.52212020
139MP0004272_abnormal_basement_membrane0.51575559
140MP0001501_abnormal_sleep_pattern0.51511312
141MP0002697_abnormal_eye_size0.51259702
142MP0005360_urolithiasis0.50846331
143MP0003718_maternal_effect0.49820778
144MP0001984_abnormal_olfaction0.49803371
145MP0005647_abnormal_sex_gland0.49562714
146MP0003045_fibrosis0.49476248
147MP0001340_abnormal_eyelid_morphology0.49292145
148MP0002733_abnormal_thermal_nociception0.49177733
149MP0005376_homeostasis/metabolism_phenot0.47888866
150MP0003880_abnormal_central_pattern0.47733247
151MP0004147_increased_porphyrin_level0.46621881
152MP0008875_abnormal_xenobiotic_pharmacok0.46591801
153MP0003567_abnormal_fetal_cardiomyocyte0.44847630
154MP0010307_abnormal_tumor_latency0.44692530
155MP0003953_abnormal_hormone_level0.44651540
156MP0001968_abnormal_touch/_nociception0.44592416
157MP0005187_abnormal_penis_morphology0.44506397
158MP0002009_preneoplasia0.43149076
159MP0001849_ear_inflammation0.42883506
160MP0002896_abnormal_bone_mineralization0.42792467
161MP0008872_abnormal_physiological_respon0.42753851
162MP0004043_abnormal_pH_regulation0.42234521
163MP0001666_abnormal_nutrient_absorption0.41846583
164MP0003283_abnormal_digestive_organ0.41725104
165MP0002909_abnormal_adrenal_gland0.41104274
166MP0005391_vision/eye_phenotype0.38435061
167MP0004215_abnormal_myocardial_fiber0.37171129
168MP0008775_abnormal_heart_ventricle0.36761147
169MP0005389_reproductive_system_phenotype0.34127969

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)9.93250550
2Hypotrichosis (HP:0001006)9.13271959
3Woolly hair (HP:0002224)8.76708994
4Metabolic alkalosis (HP:0200114)7.13635580
5Decreased circulating renin level (HP:0003351)6.97046107
6Abnormality of renin-angiotensin system (HP:0000847)6.88596959
7Pili torti (HP:0003777)6.82104229
8Abnormality of hair growth rate (HP:0011363)6.10766002
9Slow-growing hair (HP:0002217)6.10766002
10Brittle hair (HP:0002299)5.96967807
11Abnormality of chloride homeostasis (HP:0011422)5.58811446
12Abnormal hair laboratory examination (HP:0003328)5.13357799
13Hyperaldosteronism (HP:0000859)5.04446579
14Abnormality of nail color (HP:0100643)4.96834202
15Right ventricular cardiomyopathy (HP:0011663)4.94788860
16Fragile nails (HP:0001808)4.84286374
17Nail dystrophy (HP:0008404)4.81496627
18Broad face (HP:0000283)4.69691359
19Dynein arm defect of respiratory motile cilia (HP:0012255)4.61642993
20Absent/shortened dynein arms (HP:0200106)4.61642993
21Amyotrophic lateral sclerosis (HP:0007354)4.52175448
22Alkalosis (HP:0001948)4.50910626
23Onycholysis (HP:0001806)4.30665932
24Hyponatremia (HP:0002902)4.24994252
25Increased IgE level (HP:0003212)4.23655908
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.22484469
27Flat acetabular roof (HP:0003180)4.20721296
28Upper motor neuron abnormality (HP:0002127)3.92862123
29Hyperkalemia (HP:0002153)3.77909459
30Plantar hyperkeratosis (HP:0007556)3.74513249
31Hypokalemia (HP:0002900)3.71422670
32Palmoplantar hyperkeratosis (HP:0000972)3.67800002
33Abnormality of potassium homeostasis (HP:0011042)3.62824267
34Flat capital femoral epiphysis (HP:0003370)3.60814538
35Abnormality of the lower motor neuron (HP:0002366)3.45794218
36Thick nail (HP:0001805)3.38913477
37Abnormal hair whorl (HP:0010721)3.38289415
38Abdominal distention (HP:0003270)3.37131475
39Palmar hyperkeratosis (HP:0010765)3.36307326
40Milia (HP:0001056)3.35373772
41Erythema (HP:0010783)3.27536403
42Alopecia of scalp (HP:0002293)3.27037781
43Abnormality of the distal phalanx of the thumb (HP:0009617)3.26652833
44Atrophy/Degeneration involving motor neurons (HP:0007373)3.25908382
45Symphalangism affecting the phalanges of the hand (HP:0009773)3.18997933
46Abnormality of sodium homeostasis (HP:0010931)3.17896112
47Fine hair (HP:0002213)3.17054652
48Abnormality of the 1st metacarpal (HP:0010009)3.08999213
49Hand muscle atrophy (HP:0009130)3.08904276
50Male infertility (HP:0003251)3.07775137
51Infertility (HP:0000789)3.07724873
52Flattened epiphyses (HP:0003071)3.05072497
53Spastic tetraparesis (HP:0001285)2.98752515
54Neonatal short-limb short stature (HP:0008921)2.97821055
55Abnormality of monocarboxylic acid metabolism (HP:0010996)2.93649845
56Adrenal overactivity (HP:0002717)2.91037762
57Abnormality of the frontal sinuses (HP:0002687)2.90737581
58Abnormality of the aortic arch (HP:0012303)2.89857471
59Follicular hyperkeratosis (HP:0007502)2.89365045
60Curly hair (HP:0002212)2.88047046
61Abnormal sex determination (HP:0012244)2.82419727
62Sex reversal (HP:0012245)2.82419727
63Congenital sensorineural hearing impairment (HP:0008527)2.80741276
64Ventricular fibrillation (HP:0001663)2.76003279
65Abnormal respiratory motile cilium physiology (HP:0012261)2.71115097
66Conjugated hyperbilirubinemia (HP:0002908)2.63838428
67Intrahepatic cholestasis (HP:0001406)2.62623367
68Nasal polyposis (HP:0100582)2.59857448
69Visceral angiomatosis (HP:0100761)2.58744124
70Tetraplegia (HP:0002445)2.58050981
71Abnormality of the gastric mucosa (HP:0004295)2.54327738
72Enlarged epiphyses (HP:0010580)2.52343524
73Abnormal respiratory epithelium morphology (HP:0012253)2.51882814
74Abnormal respiratory motile cilium morphology (HP:0005938)2.51882814
75Chronic bronchitis (HP:0004469)2.50643563
76Amelogenesis imperfecta (HP:0000705)2.50147522
77Increased density of long bones (HP:0006392)2.47950350
78Congenital stationary night blindness (HP:0007642)2.47379913
79Intention tremor (HP:0002080)2.46867015
80Abnormal biliary tract morphology (HP:0012440)2.42374528
81Short phalanx of the thumb (HP:0009660)2.39618676
82Abnormal tarsal ossification (HP:0008369)2.39123522
83Ventricular tachycardia (HP:0004756)2.37900063
84Severe Myopia (HP:0011003)2.37421295
85Abnormal blistering of the skin (HP:0008066)2.35545977
86Vertebral clefting (HP:0008428)2.31522130
87Achilles tendon contracture (HP:0001771)2.31199315
88Upper limb muscle weakness (HP:0003484)2.29013563
89Annular pancreas (HP:0001734)2.28780183
90Akinesia (HP:0002304)2.28599297
91Ridged nail (HP:0001807)2.26309540
92Cone-rod dystrophy (HP:0000548)2.22335405
93Hemangiomatosis (HP:0007461)2.20207619
94Azoospermia (HP:0000027)2.19240270
95Abnormality of the vitamin B12 metabolism (HP:0004341)2.19093334
96Biliary tract neoplasm (HP:0100574)2.18974327
97Truncus arteriosus (HP:0001660)2.16059861
98Abnormality of glutamine family amino acid metabolism (HP:0010902)2.15695311
99Hemorrhage of the eye (HP:0011885)2.15387940
100Hoarse voice (HP:0001609)2.15358103
101Abnormal spermatogenesis (HP:0008669)2.15124088
102Progressive sensorineural hearing impairment (HP:0000408)2.14845313
103Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.13486888
104Short 1st metacarpal (HP:0010034)2.13486888
105Abnormality of the phalanges of the hallux (HP:0010057)2.13420360
106Abnormality of the Achilles tendon (HP:0005109)2.10519285
107Hematochezia (HP:0002573)2.08718131
108Urethral obstruction (HP:0000796)2.08527254
109Abnormality of the nasal mucosa (HP:0000433)2.07224828
110Protuberant abdomen (HP:0001538)2.07130261
111Gonadotropin excess (HP:0000837)2.06909360
112Syncope (HP:0001279)2.05181181
113Abnormality of the neuromuscular junction (HP:0003398)2.03734177
114Fatigable weakness (HP:0003473)2.03734177
115Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.03550616
116Rhinitis (HP:0012384)2.01556952
117Abnormality of the corticospinal tract (HP:0002492)2.01522405
118Abnormal foot bone ossification (HP:0010675)2.01187169
119Type II diabetes mellitus (HP:0005978)1.99038204
120Abnormality of vitamin B metabolism (HP:0004340)1.98737769
121Abnormality of the dental root (HP:0006486)1.98559593
122Taurodontia (HP:0000679)1.98559593
123Abnormality of permanent molar morphology (HP:0011071)1.98559593
124Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.98322298
125Clumsiness (HP:0002312)1.98148599
126Atrophic scars (HP:0001075)1.97933376
127Sparse eyelashes (HP:0000653)1.96436012
128Aplasia cutis congenita (HP:0001057)1.96342149
129Dehydration (HP:0001944)1.95749043
130Abnormality of the musculature of the pelvis (HP:0001469)1.95584633
131Abnormality of the hip-girdle musculature (HP:0001445)1.95584633
132Abnormal ciliary motility (HP:0012262)1.95504031
133Abnormal hand bone ossification (HP:0010660)1.93417417
134Aplasia/hypoplasia of the femur (HP:0005613)1.93357775
135Concave nail (HP:0001598)1.93163807
136Cerebral inclusion bodies (HP:0100314)1.93069626
137Abnormality of molar morphology (HP:0011070)1.92542021
138Abnormality of molar (HP:0011077)1.92542021
139Hyporeflexia of lower limbs (HP:0002600)1.91835351
140Advanced eruption of teeth (HP:0006288)1.88393347
141Abnormality of vitamin metabolism (HP:0100508)1.88057227
142Exotropia (HP:0000577)1.87493781
143Spontaneous hematomas (HP:0007420)1.87007157
144Tetany (HP:0001281)1.86572006
145Resting tremor (HP:0002322)1.85700754
146Focal motor seizures (HP:0011153)1.85637985
147Abnormality of carpal bone ossification (HP:0006257)1.83952019
148Abnormality of oral frenula (HP:0000190)1.83661734
149Intellectual disability, profound (HP:0002187)1.83188201
150Limb-girdle muscle atrophy (HP:0003797)1.82319514
151Increased circulating renin level (HP:0000848)1.81175483
152Bundle branch block (HP:0011710)1.81018369
153Abnormality of the proximal phalanges of the hand (HP:0009834)1.80882389
154Mildly elevated creatine phosphokinase (HP:0008180)1.80873193
155Generalized aminoaciduria (HP:0002909)1.80402280
156Abnormality of small intestinal villus morphology (HP:0011472)1.79997260
157Villous atrophy (HP:0011473)1.79997260
158Abnormal vertebral ossification (HP:0100569)1.79792671
159Poor speech (HP:0002465)1.79559549
160Natal tooth (HP:0000695)1.78994704
161Microretrognathia (HP:0000308)1.78659897
162Broad hallux (HP:0010055)1.78592868
163Malnutrition (HP:0004395)1.78534990
164Torticollis (HP:0000473)1.78242649
165Hypercortisolism (HP:0001578)1.75200106
166Ileus (HP:0002595)1.74586432
167Myokymia (HP:0002411)1.74297640
168Dry hair (HP:0011359)1.74140748
169Distal upper limb amyotrophy (HP:0007149)1.74049751
170Upper limb amyotrophy (HP:0009129)1.74049751
171Aplasia/Hypoplasia of the tibia (HP:0005772)1.73437451
172Irregular epiphyses (HP:0010582)1.73203868
173Opisthotonus (HP:0002179)1.72948113
174Rectal prolapse (HP:0002035)1.72865696
175Short middle phalanx of finger (HP:0005819)1.71998396
176Short tibia (HP:0005736)1.71505570
177Abnormality of the middle phalanges of the toes (HP:0010183)1.71146360
178Abnormality of the dental pulp (HP:0006479)1.70947245
179Double outlet right ventricle (HP:0001719)1.70154286
180Congenital malformation of the right heart (HP:0011723)1.70154286
181Lower limb amyotrophy (HP:0007210)1.69919126
182Widely spaced teeth (HP:0000687)1.69632643
183Renal salt wasting (HP:0000127)1.68216970
184Hypoplasia of the uterus (HP:0000013)1.68006378
185Ankyloglossia (HP:0010296)1.67517115
186Neurofibrillary tangles (HP:0002185)1.67352384
187Testicular neoplasm (HP:0010788)1.67302317
188Atonic seizures (HP:0010819)1.67199246
189Colitis (HP:0002583)1.65619363

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME18.97246985
2TIE17.34671648
3ACVR1B5.58749774
4PIK3CA4.00278385
5PRKD33.27361854
6TESK13.12554321
7EPHA43.00552924
8ICK2.88917338
9MUSK2.79131675
10GRK12.78493102
11FER2.73844405
12PDK42.57221444
13PDK32.57221444
14EPHB22.50760162
15RIPK42.46802250
16MAPKAPK32.44901417
17BMX2.44361200
18EEF2K2.39516746
19PIK3CG2.35779181
20LMTK22.29946295
21LATS21.87607049
22ALK1.82826588
23DMPK1.68559605
24EPHA21.57130147
25PTK2B1.55412724
26PDK21.52808907
27OXSR11.50805456
28MET1.47785593
29MAP3K21.47489242
30ARAF1.42673599
31NTRK31.39354270
32DDR21.39210561
33CAMKK11.38465719
34LIMK11.27466071
35CAMKK21.27230720
36EPHB11.23659596
37CAMK1G1.19540878
38CAMK1D1.16447966
39PIM21.15969456
40KSR21.15551661
41MAP3K91.14122582
42PINK11.13230869
43DAPK21.06596289
44PAK61.04930304
45MST1R1.02781880
46PLK40.97614379
47PDK10.96919297
48PDPK10.96881764
49TAOK10.95925681
50MST40.94789737
51BRD40.93128533
52STK240.92926142
53STK380.90473931
54STK110.89128198
55TYRO30.87525386
56NEK60.79206063
57NEK90.78123964
58ERN10.75807468
59LATS10.73323525
60BRAF0.71700585
61NUAK10.70619233
62RPS6KA60.69984672
63MAPK150.69298371
64TESK20.69283477
65PRKCG0.68036570
66ERBB30.66238934
67MAP2K20.65537591
68CDK60.63277499
69MAP2K10.63014505
70RPS6KA20.61781561
71WNK40.61599317
72RPS6KC10.61195734
73RPS6KL10.61195734
74MINK10.60530099
75PAK40.59818443
76FRK0.59528196
77PRPF4B0.58655954
78CAMK2B0.58615351
79RPS6KB20.58144682
80RIPK10.57174180
81TRPM70.56854635
82MAP3K10.55969231
83PRKCE0.54758183
84EIF2AK10.53221655
85MAP3K100.50305595
86DYRK1B0.49343566
87MAP2K60.48129952
88KSR10.48047408
89NTRK20.47898828
90ABL20.47295086
91CAMK40.46301063
92CDK190.46121147
93CDK120.46002141
94PRKCQ0.45825855
95STK390.45109861
96MAP3K40.45061643
97TEC0.43455879
98PRKG20.43432619
99GRK60.43319022
100STK38L0.43007753
101CAMK2A0.42253513
102PRKCI0.42154504
103NTRK10.41994665
104PTK60.41270774
105WNK10.39233658
106ROCK10.37796566
107CAMK10.37174219
108INSRR0.36949057
109PRKCH0.36017482
110MAP2K40.35122598
111MATK0.35104190
112GRK50.35092782
113TNK20.35043490
114MARK10.34660608
115MAPK110.34037962
116STK30.33672486
117PRKAA20.33258600
118DAPK10.33169650
119CSNK1E0.32979915
120MAP3K60.32711572
121CAMK2G0.32677768
122PRKCZ0.31319935
123CDK50.30595184
124MYLK0.29632334
125PTK20.29169307
126CASK0.28949549
127PRKCA0.27598302
128RPS6KA10.27028272
129PAK20.26699368
130MAP3K70.26615295
131TAF10.26319610
132PRKAA10.25632999
133CAMK2D0.25290740
134PRKCB0.24565972
135PRKACG0.24361627
136SRC0.24105535
137PLK20.23941493
138BMPR1B0.23415250
139SGK10.22962938
140HCK0.22665998
141PAK30.22490532
142RPS6KB10.22397532
143MAPK130.22127950
144PDGFRA0.22064031
145PHKG20.18797807
146PHKG10.18797807
147AURKA0.17751436
148PRKACA0.15728520
149PRKD20.13571496
150CDK10.13473221
151MAP3K80.12409382
152MARK20.11208575

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.07341186
2Fat digestion and absorption_Homo sapiens_hsa049753.03315963
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.62621592
4Retinol metabolism_Homo sapiens_hsa008302.61156407
5Mineral absorption_Homo sapiens_hsa049782.53511924
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.46405238
7Linoleic acid metabolism_Homo sapiens_hsa005912.37217804
8Long-term potentiation_Homo sapiens_hsa047202.26382779
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.23706807
10Histidine metabolism_Homo sapiens_hsa003402.18307429
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.08574925
12Gastric acid secretion_Homo sapiens_hsa049712.02577792
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.99673923
14Caffeine metabolism_Homo sapiens_hsa002321.95576561
15Salivary secretion_Homo sapiens_hsa049701.92190520
16Dorso-ventral axis formation_Homo sapiens_hsa043201.89843622
17Amphetamine addiction_Homo sapiens_hsa050311.87461482
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79539425
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78610734
20Renin secretion_Homo sapiens_hsa049241.69959492
21Fatty acid degradation_Homo sapiens_hsa000711.69534677
22Bile secretion_Homo sapiens_hsa049761.62684779
23Nitrogen metabolism_Homo sapiens_hsa009101.60195788
24Fatty acid biosynthesis_Homo sapiens_hsa000611.57572832
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57404160
26Olfactory transduction_Homo sapiens_hsa047401.56620131
27Arginine and proline metabolism_Homo sapiens_hsa003301.44436718
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42843503
29Pancreatic secretion_Homo sapiens_hsa049721.40995172
30Circadian entrainment_Homo sapiens_hsa047131.39784290
31Glutamatergic synapse_Homo sapiens_hsa047241.39713984
32Tryptophan metabolism_Homo sapiens_hsa003801.39025881
33GnRH signaling pathway_Homo sapiens_hsa049121.38397034
34Chemical carcinogenesis_Homo sapiens_hsa052041.35817109
35Ether lipid metabolism_Homo sapiens_hsa005651.35290167
36Nicotine addiction_Homo sapiens_hsa050331.35287347
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34720581
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.31965217
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.31810112
40Vitamin digestion and absorption_Homo sapiens_hsa049771.31308023
41Synaptic vesicle cycle_Homo sapiens_hsa047211.30816639
42Insulin secretion_Homo sapiens_hsa049111.30726057
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29811420
44Phototransduction_Homo sapiens_hsa047441.27861774
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26341590
46Glucagon signaling pathway_Homo sapiens_hsa049221.25253320
47Melanogenesis_Homo sapiens_hsa049161.23675728
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.23413672
49Glycerophospholipid metabolism_Homo sapiens_hsa005641.22666226
50Oxytocin signaling pathway_Homo sapiens_hsa049211.21993256
51PPAR signaling pathway_Homo sapiens_hsa033201.21356063
52Estrogen signaling pathway_Homo sapiens_hsa049151.21107416
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20020548
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.19343110
55Selenocompound metabolism_Homo sapiens_hsa004501.19087958
56Long-term depression_Homo sapiens_hsa047301.15729053
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15682174
58Calcium signaling pathway_Homo sapiens_hsa040201.15489848
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10282774
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10249287
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10199851
62Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10054987
63Tight junction_Homo sapiens_hsa045301.07593451
64Arginine biosynthesis_Homo sapiens_hsa002201.05380975
65Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03900055
66Butanoate metabolism_Homo sapiens_hsa006501.03680964
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02271383
68Dopaminergic synapse_Homo sapiens_hsa047280.96892041
69Morphine addiction_Homo sapiens_hsa050320.96692691
70VEGF signaling pathway_Homo sapiens_hsa043700.94539618
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93895830
72Cholinergic synapse_Homo sapiens_hsa047250.91875193
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91743870
74Collecting duct acid secretion_Homo sapiens_hsa049660.91194958
75Oocyte meiosis_Homo sapiens_hsa041140.91097116
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91065257
77Starch and sucrose metabolism_Homo sapiens_hsa005000.90531105
78Renin-angiotensin system_Homo sapiens_hsa046140.90007911
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89619574
80Protein digestion and absorption_Homo sapiens_hsa049740.88841777
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88748435
82Sulfur relay system_Homo sapiens_hsa041220.88394986
83Axon guidance_Homo sapiens_hsa043600.88129104
84Arachidonic acid metabolism_Homo sapiens_hsa005900.87828971
85Taste transduction_Homo sapiens_hsa047420.87596646
86cAMP signaling pathway_Homo sapiens_hsa040240.86943015
87Sphingolipid metabolism_Homo sapiens_hsa006000.86690781
88Regulation of autophagy_Homo sapiens_hsa041400.85836152
89Thyroid hormone synthesis_Homo sapiens_hsa049180.85150513
90Fructose and mannose metabolism_Homo sapiens_hsa000510.84189653
91Rap1 signaling pathway_Homo sapiens_hsa040150.76635212
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74819830
93Hedgehog signaling pathway_Homo sapiens_hsa043400.74796183
94Glioma_Homo sapiens_hsa052140.71551074
95GABAergic synapse_Homo sapiens_hsa047270.70227346
96Wnt signaling pathway_Homo sapiens_hsa043100.69798584
97Glycerolipid metabolism_Homo sapiens_hsa005610.68429369
98Ras signaling pathway_Homo sapiens_hsa040140.67668053
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67038001
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66829858
101Gap junction_Homo sapiens_hsa045400.66717208
102Basal cell carcinoma_Homo sapiens_hsa052170.66662407
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66001094
104Inositol phosphate metabolism_Homo sapiens_hsa005620.65842824
105Fatty acid metabolism_Homo sapiens_hsa012120.64477316
106Adherens junction_Homo sapiens_hsa045200.62727997
107Cocaine addiction_Homo sapiens_hsa050300.61079926
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59379568
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.57931477
110Endocytosis_Homo sapiens_hsa041440.57084607
111Hippo signaling pathway_Homo sapiens_hsa043900.56658497
112HIF-1 signaling pathway_Homo sapiens_hsa040660.51596254
113Dilated cardiomyopathy_Homo sapiens_hsa054140.51565935
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51518105
115ABC transporters_Homo sapiens_hsa020100.51215317
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.49775499
117Other glycan degradation_Homo sapiens_hsa005110.48886670
118ErbB signaling pathway_Homo sapiens_hsa040120.46816308
119Salmonella infection_Homo sapiens_hsa051320.45705246
120Fatty acid elongation_Homo sapiens_hsa000620.45483398
121Ovarian steroidogenesis_Homo sapiens_hsa049130.44314450
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43247018
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.42225533
124Non-small cell lung cancer_Homo sapiens_hsa052230.41757101
125Tyrosine metabolism_Homo sapiens_hsa003500.41363676
126Pyruvate metabolism_Homo sapiens_hsa006200.40377842
127Glutathione metabolism_Homo sapiens_hsa004800.39316922
128Serotonergic synapse_Homo sapiens_hsa047260.38657777
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37238021
130Endometrial cancer_Homo sapiens_hsa052130.35925243
131Metabolic pathways_Homo sapiens_hsa011000.35881120
132Galactose metabolism_Homo sapiens_hsa000520.35362037
133beta-Alanine metabolism_Homo sapiens_hsa004100.35336612
134MAPK signaling pathway_Homo sapiens_hsa040100.34371555
135Choline metabolism in cancer_Homo sapiens_hsa052310.33298100
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32786421
137Type II diabetes mellitus_Homo sapiens_hsa049300.32044477
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.31866561
139TGF-beta signaling pathway_Homo sapiens_hsa043500.24997537
140Propanoate metabolism_Homo sapiens_hsa006400.24846774
141Hepatitis C_Homo sapiens_hsa051600.24622106
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21611811
143Cardiac muscle contraction_Homo sapiens_hsa042600.16967486
144Thyroid cancer_Homo sapiens_hsa052160.16556859
145Phenylalanine metabolism_Homo sapiens_hsa003600.12426732
146One carbon pool by folate_Homo sapiens_hsa006700.11571905
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.09570482
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09291238
149Lysine degradation_Homo sapiens_hsa003100.08180519
150Adipocytokine signaling pathway_Homo sapiens_hsa049200.08118066
151Peroxisome_Homo sapiens_hsa041460.05292764
152Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.05084032
153Huntingtons disease_Homo sapiens_hsa050160.04681292
154Insulin resistance_Homo sapiens_hsa049310.04504725

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