OTOP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)9.51338437
2phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)8.85668903
3intestinal cholesterol absorption (GO:0030299)8.72332355
4angiotensin maturation (GO:0002003)6.82086733
5desmosome organization (GO:0002934)6.20933332
6vitamin A metabolic process (GO:0006776)6.17480903
7retinal cone cell development (GO:0046549)6.14641481
8growth hormone secretion (GO:0030252)5.91391673
9adhesion of symbiont to host cell (GO:0044650)5.55792264
10virion attachment to host cell (GO:0019062)5.55792264
11regulation of rhodopsin mediated signaling pathway (GO:0022400)5.51481272
12peptide cross-linking (GO:0018149)5.43569709
13rhodopsin mediated signaling pathway (GO:0016056)5.36198423
14phospholipid efflux (GO:0033700)5.08211303
15regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.07549173
16regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.01000406
17flavonoid metabolic process (GO:0009812)5.00094473
18phototransduction (GO:0007602)4.97585052
19adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.97449827
20phototransduction, visible light (GO:0007603)4.88322429
21positive regulation of growth hormone secretion (GO:0060124)4.78502616
22detection of light stimulus (GO:0009583)4.77954341
23detection of visible light (GO:0009584)4.76949270
24adhesion of symbiont to host (GO:0044406)4.65699792
25Arp2/3 complex-mediated actin nucleation (GO:0034314)4.64245707
26drinking behavior (GO:0042756)4.61327851
27hydrogen peroxide biosynthetic process (GO:0050665)4.58938765
28photoreceptor cell development (GO:0042461)4.56121697
29photoreceptor cell maintenance (GO:0045494)4.48340055
30negative regulation of cAMP-mediated signaling (GO:0043951)4.43150682
31long term synaptic depression (GO:0060292)4.42553825
32eye photoreceptor cell development (GO:0042462)4.40530388
33detection of light stimulus involved in visual perception (GO:0050908)4.39073939
34detection of light stimulus involved in sensory perception (GO:0050962)4.39073939
35keratinocyte differentiation (GO:0030216)4.36247995
36regulation of water loss via skin (GO:0033561)4.29436210
37actin nucleation (GO:0045010)4.28312976
38establishment of skin barrier (GO:0061436)4.20564996
39triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.14552448
40bundle of His cell to Purkinje myocyte communication (GO:0086069)4.13238860
41regulation of ruffle assembly (GO:1900027)4.10897754
42synaptic transmission, dopaminergic (GO:0001963)4.09009586
43reactive oxygen species biosynthetic process (GO:1903409)4.07501282
44regulation of triglyceride catabolic process (GO:0010896)4.06540082
45keratinization (GO:0031424)4.05023577
46positive regulation of guanylate cyclase activity (GO:0031284)4.03391388
47regulation of guanylate cyclase activity (GO:0031282)4.02676032
48substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.00041193
49substrate-independent telencephalic tangential migration (GO:0021826)4.00041193
50cholesterol efflux (GO:0033344)3.96277894
51NIK/NF-kappaB signaling (GO:0038061)3.95460789
52regulation of systemic arterial blood pressure by hormone (GO:0001990)3.89874809
53regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.89874809
54endocrine process (GO:0050886)3.89874809
55diacylglycerol metabolic process (GO:0046339)3.88960701
56plasma lipoprotein particle assembly (GO:0034377)3.88457782
57digestive system process (GO:0022600)3.87803801
58regulation of penile erection (GO:0060405)3.87743915
59regulation of cholesterol esterification (GO:0010872)3.85895987
60coenzyme catabolic process (GO:0009109)3.84651379
61positive regulation of lipoprotein lipase activity (GO:0051006)3.84560376
62positive regulation of triglyceride lipase activity (GO:0061365)3.84560376
63radial glial cell differentiation (GO:0060019)3.84253437
64actin filament depolymerization (GO:0030042)3.82918946
65phenylpropanoid metabolic process (GO:0009698)3.82382519
66respiratory burst (GO:0045730)3.81876997
67drug catabolic process (GO:0042737)3.81410601
68positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.79623801
69positive regulation of T cell differentiation in thymus (GO:0033089)3.77719145
703-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.71752075
71purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.71752075
72protein-lipid complex assembly (GO:0065005)3.71667293
73eye photoreceptor cell differentiation (GO:0001754)3.71576103
74photoreceptor cell differentiation (GO:0046530)3.71576103
75mitochondrial calcium ion transport (GO:0006851)3.60281705
76transmission of nerve impulse (GO:0019226)3.58590699
77transepithelial transport (GO:0070633)3.55936612
78sphingomyelin metabolic process (GO:0006684)3.55563626
79dopamine transport (GO:0015872)3.53560462
80protein-chromophore linkage (GO:0018298)3.53464865
81I-kappaB phosphorylation (GO:0007252)3.51816288
82lymph node development (GO:0048535)3.50068131
83sphingoid metabolic process (GO:0046519)3.49933438
84modified amino acid transport (GO:0072337)3.46278647
85lipoprotein transport (GO:0042953)3.45677290
86B cell receptor signaling pathway (GO:0050853)3.45050046
87nucleoside diphosphate catabolic process (GO:0009134)3.44463311
88positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.44049316
89response to superoxide (GO:0000303)3.42198487
90glucose 6-phosphate metabolic process (GO:0051156)3.40988018
91very-low-density lipoprotein particle assembly (GO:0034379)3.39915831
92regulation of antigen processing and presentation (GO:0002577)3.39798563
93detection of external stimulus (GO:0009581)3.39173322
94detection of abiotic stimulus (GO:0009582)3.37007780
95negative regulation of thymocyte apoptotic process (GO:0070244)3.35567070
96epidermal cell differentiation (GO:0009913)3.34361507
97retinoid metabolic process (GO:0001523)3.31945172
98purine nucleotide salvage (GO:0032261)3.30431078
99regulation of systemic arterial blood pressure (GO:0003073)3.28980083
100hormone catabolic process (GO:0042447)3.26788813
101sensory perception of light stimulus (GO:0050953)3.25994127
102regulation of digestive system process (GO:0044058)3.25854006
103negative thymic T cell selection (GO:0045060)3.25091889
104visual perception (GO:0007601)3.24458880
105lipoprotein metabolic process (GO:0042157)3.20248678
106positive thymic T cell selection (GO:0045059)3.19078192
107superoxide anion generation (GO:0042554)3.18865218
108cellular glucuronidation (GO:0052695)3.18843537
109regulation of metalloenzyme activity (GO:0048552)3.17847747
110fat-soluble vitamin biosynthetic process (GO:0042362)3.15763973
111embryonic process involved in female pregnancy (GO:0060136)3.12957425
112positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12677533
113mating behavior (GO:0007617)3.12643341
114phospholipid scrambling (GO:0017121)3.12085658
115icosanoid transport (GO:0071715)3.11853508
116fatty acid derivative transport (GO:1901571)3.11853508
117water homeostasis (GO:0030104)3.11487001
118diterpenoid metabolic process (GO:0016101)3.09097295
119negative regulation of sterol transport (GO:0032372)3.07488314
120negative regulation of cholesterol transport (GO:0032375)3.07488314
121sphingosine metabolic process (GO:0006670)3.06909392
122regulation of G0 to G1 transition (GO:0070316)3.06840141
123cholesterol transport (GO:0030301)3.06549427
124sterol transport (GO:0015918)3.06549427
125diol metabolic process (GO:0034311)3.06250043
126regulation of dendritic cell antigen processing and presentation (GO:0002604)3.05193009
127negative T cell selection (GO:0043383)3.03120226
128regulation of bile acid biosynthetic process (GO:0070857)3.02962615
129activation of adenylate cyclase activity (GO:0007190)3.02537006
130regulation of interferon-beta biosynthetic process (GO:0045357)3.01838444
131arachidonic acid secretion (GO:0050482)3.00031236
132icosanoid secretion (GO:0032309)3.00031236
133determination of adult lifespan (GO:0008340)2.98815869
134bile acid and bile salt transport (GO:0015721)2.98245745
135deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.96319621
136sulfate transmembrane transport (GO:1902358)2.94262503
137positive regulation of antigen processing and presentation (GO:0002579)2.93967367
138peristalsis (GO:0030432)2.92868650
139response to oxygen radical (GO:0000305)2.91132995
140uronic acid metabolic process (GO:0006063)2.89707269
141glucuronate metabolic process (GO:0019585)2.89707269
142peptide hormone processing (GO:0016486)2.87358301
143atrioventricular valve morphogenesis (GO:0003181)2.87174732
144reverse cholesterol transport (GO:0043691)2.87047027
145digestion (GO:0007586)2.86664562
146terpenoid metabolic process (GO:0006721)2.85405656
147regulation of germinal center formation (GO:0002634)2.85087481
148regulation of transforming growth factor beta1 production (GO:0032908)2.83591077
149multicellular organismal water homeostasis (GO:0050891)2.80846405
150long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.80395559
151negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.79489207
152positive regulation of lyase activity (GO:0051349)2.79157132
153detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.78964602
154intestinal epithelial cell development (GO:0060576)2.78524935
155positive regulation of fatty acid biosynthetic process (GO:0045723)2.77993368
156histamine secretion (GO:0001821)2.77517084
157pyrimidine ribonucleoside catabolic process (GO:0046133)2.77349489
158polyol transport (GO:0015791)2.76363086
159regulation of cellular extravasation (GO:0002691)2.76179790
160negative regulation of digestive system process (GO:0060457)2.75828401
161retinal rod cell development (GO:0046548)2.75614537
162glomerular visceral epithelial cell development (GO:0072015)2.73704027
163cholesterol homeostasis (GO:0042632)2.73088817
164oligosaccharide catabolic process (GO:0009313)2.71721710
165citrulline biosynthetic process (GO:0019240)2.69988459
166regulation of growth hormone secretion (GO:0060123)2.69374378
167sequestering of actin monomers (GO:0042989)2.68622975
168immunoglobulin mediated immune response (GO:0016064)2.68462824
169negative regulation of gene silencing (GO:0060969)2.68354398
170positive regulation of cyclase activity (GO:0031281)2.68285833
171positive regulation of adenylate cyclase activity (GO:0045762)2.67173516
172developmental pigmentation (GO:0048066)2.63504091
173lens fiber cell development (GO:0070307)2.63382294
174regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.61902021
175regulation of interferon-gamma biosynthetic process (GO:0045072)2.59398235
176epoxygenase P450 pathway (GO:0019373)2.56604011
177negative regulation of telomere maintenance (GO:0032205)2.56398108
178regulation of interleukin-4 production (GO:0032673)2.53871525
179antigen receptor-mediated signaling pathway (GO:0050851)2.53825102
180tongue development (GO:0043586)2.53271347
181asymmetric protein localization (GO:0008105)2.52028246
182somatic stem cell division (GO:0048103)2.52012430
183positive regulation of B cell differentiation (GO:0045579)2.50450977
184cofactor catabolic process (GO:0051187)2.49454135
185tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.48359242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat9.88969426
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.95361644
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.49575960
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.36533734
5CDX2_20551321_ChIP-Seq_CACO-2_Human3.29787814
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.05343010
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.93650581
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.80124237
9GATA1_22025678_ChIP-Seq_K562_Human2.18096485
10SOX2_27498859_Chip-Seq_STOMACH_Mouse2.07693694
11TP63_17297297_ChIP-ChIP_HaCaT_Human12.2665885
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93327113
13SOX2_20726797_ChIP-Seq_SW620_Human1.83862388
14HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74967467
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70674969
16GATA4_25053715_ChIP-Seq_YYC3_Human1.70315352
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.69582344
18TCF4_18268006_ChIP-ChIP_LS174T_Human1.60215749
19GATA6_25053715_ChIP-Seq_YYC3_Human1.58334692
20P63_26484246_Chip-Seq_KERATINOCYTES_Human1.58287452
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51140534
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50282649
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49532391
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46719092
25RUNX_20019798_ChIP-Seq_JUKART_Human1.45645786
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45267476
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42088401
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41553665
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.40964891
30* BCOR_27268052_Chip-Seq_Bcells_Human1.38506921
31PPARA_22158963_ChIP-Seq_LIVER_Mouse1.38504927
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37397786
33SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37332456
34PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.36898500
35CTCF_27219007_Chip-Seq_Bcells_Human1.36575632
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33560676
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.33424597
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.32586166
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.31243719
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.31013809
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29564990
42KLF5_25053715_ChIP-Seq_YYC3_Human1.29532637
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29490838
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.27337521
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26909445
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26620693
47* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26052324
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25200610
49VDR_22108803_ChIP-Seq_LS180_Human1.22733540
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.22373719
51E2F1_20622854_ChIP-Seq_HELA_Human1.22274638
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22140343
53AR_20517297_ChIP-Seq_VCAP_Human1.21430276
54GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.19392099
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19109859
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18972454
57PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18573266
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18513476
59SMC4_20622854_ChIP-Seq_HELA_Human1.14961093
60TAF2_19829295_ChIP-Seq_ESCs_Human1.11034805
61PHF8_20622854_ChIP-Seq_HELA_Human1.10577257
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10391934
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10252859
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10114141
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09958135
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.08555061
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08318590
68MYB_26560356_Chip-Seq_TH2_Human1.08189999
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07919875
70* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07564560
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05364655
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04722378
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04446598
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04163738
75KDM2B_26808549_Chip-Seq_K562_Human1.03955178
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03846381
77* CEBPB_22108803_ChIP-Seq_LS180_Human1.03729632
78* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03389354
79P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.01777057
80ERA_21632823_ChIP-Seq_H3396_Human1.01730222
81GATA3_24758297_ChIP-Seq_MCF-7_Human1.01300199
82SMAD3_21741376_ChIP-Seq_HESCs_Human0.99839077
83LXR_22292898_ChIP-Seq_THP-1_Human0.99422582
84TP63_23658742_ChIP-Seq_EP156T_Human0.99139198
85JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98414537
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98137597
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97860515
88CREB1_26743006_Chip-Seq_LNCaP_Human0.97682281
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97535832
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97316631
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97013404
92GATA1_19941826_ChIP-Seq_K562_Human0.96908296
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96112436
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95677686
95RACK7_27058665_Chip-Seq_MCF-7_Human0.95608662
96RAC3_21632823_ChIP-Seq_H3396_Human0.95177400
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94557609
98OCT1_27270436_Chip-Seq_PROSTATE_Human0.94185797
99OCT4_20526341_ChIP-Seq_ESCs_Human0.94127413
100* P300_27268052_Chip-Seq_Bcells_Human0.93717882
101ERG_20517297_ChIP-Seq_VCAP_Human0.93648565
102SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.93428672
103ATF3_27146783_Chip-Seq_COLON_Human0.93361503
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93290060
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92404494
106* SPI1_20517297_ChIP-Seq_HL60_Human0.92353370
107* TP63_22573176_ChIP-Seq_HFKS_Human0.90987651
108NANOG_20526341_ChIP-Seq_ESCs_Human0.90817279
109BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90515038
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90435875
111MYB_26560356_Chip-Seq_TH1_Human0.90218027
112EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90126659
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90046024
114JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89969059
115BCAT_22108803_ChIP-Seq_LS180_Human0.89733681
116IRF8_27001747_Chip-Seq_BMDM_Mouse0.89727724
117UTX_26944678_Chip-Seq_JUKART_Human0.89711622
118GATA3_27048872_Chip-Seq_THYMUS_Human0.89512025
119CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89200876
120EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89109526
121RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88789470
122KLF4_19829295_ChIP-Seq_ESCs_Human0.88646030
123STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88135315
124RNF2_18974828_ChIP-Seq_MESCs_Mouse0.88124960
125EZH2_18974828_ChIP-Seq_MESCs_Mouse0.88124960
126AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87057361
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87037650
128SA1_27219007_Chip-Seq_Bcells_Human0.87000174
129SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86677598
130GATA2_19941826_ChIP-Seq_K562_Human0.86362217
131ZNF263_19887448_ChIP-Seq_K562_Human0.86287125
132RXR_22108803_ChIP-Seq_LS180_Human0.85381104
133EZH2_22144423_ChIP-Seq_EOC_Human0.84861823
134* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.84274985
135SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.84158295
136GATA6_21074721_ChIP-Seq_CACO-2_Human0.83557045
137MTF2_20144788_ChIP-Seq_MESCs_Mouse0.83411616
138NCOR_22424771_ChIP-Seq_293T_Human0.83314104
139EGR1_19032775_ChIP-ChIP_M12_Human0.83016344
140SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.82156214
141PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.82104415
142* SOX2_21211035_ChIP-Seq_LN229_Human0.82046677
143PIAS1_25552417_ChIP-Seq_VCAP_Human0.79995897
144AHR_22903824_ChIP-Seq_MCF-7_Human0.79953462
145SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79514261
146SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79514261
147SCL_19346495_ChIP-Seq_HPC-7_Human0.78915657
148SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.78107086
149* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77183651
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76548370
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75953449
152DROSHA_22980978_ChIP-Seq_HELA_Human0.75907378
153CJUN_26792858_Chip-Seq_BT549_Human0.74373633
154* BCL6_27268052_Chip-Seq_Bcells_Human0.73303097
155FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73135681
156DNAJC2_21179169_ChIP-ChIP_NT2_Human0.72701950
157P300_27058665_Chip-Seq_ZR-75-30cells_Human0.72255986
158P68_20966046_ChIP-Seq_HELA_Human0.71203982
159MYC_19829295_ChIP-Seq_ESCs_Human0.71043267
160AR_21572438_ChIP-Seq_LNCaP_Human0.70657961
161CTCF_20526341_ChIP-Seq_ESCs_Human0.70286660
162FOXA1_21572438_ChIP-Seq_LNCaP_Human0.69940874
163CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.69442989
164SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.69366335
165UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.69321433
166RNF2_27304074_Chip-Seq_ESCs_Mouse0.68842838
167EED_16625203_ChIP-ChIP_MESCs_Mouse0.68662779
168RARG_19884340_ChIP-ChIP_MEFs_Mouse0.66954309

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.53925139
2MP0003011_delayed_dark_adaptation5.89376914
3MP0010234_abnormal_vibrissa_follicle4.90121637
4MP0001666_abnormal_nutrient_absorption4.66187611
5MP0003880_abnormal_central_pattern4.46943235
6MP0005551_abnormal_eye_electrophysiolog4.44022799
7MP0002796_impaired_skin_barrier4.29974855
8MP0005377_hearing/vestibular/ear_phenot3.43281126
9MP0003878_abnormal_ear_physiology3.43281126
10MP0006072_abnormal_retinal_apoptosis3.42907577
11MP0002139_abnormal_hepatobiliary_system3.26293340
12MP0003183_abnormal_peptide_metabolism3.02804795
13MP0005253_abnormal_eye_physiology2.81984011
14MP0003252_abnormal_bile_duct2.71449961
15MP0009840_abnormal_foam_cell2.63559106
16MP0005645_abnormal_hypothalamus_physiol2.58228321
17MP0005501_abnormal_skin_physiology2.46144241
18MP0002102_abnormal_ear_morphology2.40149462
19MP0003950_abnormal_plasma_membrane2.26139785
20MP0005671_abnormal_response_to2.08204171
21MP0003941_abnormal_skin_development2.07117158
22MP0005085_abnormal_gallbladder_physiolo2.03355646
23MP0005275_abnormal_skin_tensile2.02671932
24MP0001501_abnormal_sleep_pattern2.00598951
25MP0000462_abnormal_digestive_system1.94886230
26MP0009780_abnormal_chondrocyte_physiolo1.92418444
27MP0004019_abnormal_vitamin_homeostasis1.90678432
28MP0002254_reproductive_system_inflammat1.87752816
29MP0003172_abnormal_lysosome_physiology1.85413742
30MP0001485_abnormal_pinna_reflex1.77679963
31MP0008875_abnormal_xenobiotic_pharmacok1.76866492
32MP0004043_abnormal_pH_regulation1.73395535
33MP0010329_abnormal_lipoprotein_level1.73218399
34MP0002095_abnormal_skin_pigmentation1.66220503
35MP0000015_abnormal_ear_pigmentation1.65955538
36MP0005332_abnormal_amino_acid1.64832459
37MP0004264_abnormal_extraembryonic_tissu1.64122852
38MP0001800_abnormal_humoral_immune1.62696867
39MP0008004_abnormal_stomach_pH1.62495572
40MP0000026_abnormal_inner_ear1.61437794
41MP0002098_abnormal_vibrissa_morphology1.55557927
42MP0002090_abnormal_vision1.54448472
43MP0001216_abnormal_epidermal_layer1.53945779
44MP0005195_abnormal_posterior_eye1.53137542
45MP0010678_abnormal_skin_adnexa1.50140163
46MP0009785_altered_susceptibility_to1.50091244
47MP0006138_congestive_heart_failure1.48937821
48MP0003136_yellow_coat_color1.47660257
49MP0005387_immune_system_phenotype1.44082279
50MP0001790_abnormal_immune_system1.44082279
51MP0001324_abnormal_eye_pigmentation1.43697301
52MP0009643_abnormal_urine_homeostasis1.43129120
53MP0003705_abnormal_hypodermis_morpholog1.39909596
54MP0005075_abnormal_melanosome_morpholog1.36723812
55MP0003866_abnormal_defecation1.36445004
56MP0000467_abnormal_esophagus_morphology1.35933368
57MP0003879_abnormal_hair_cell1.33655101
58MP0002234_abnormal_pharynx_morphology1.32700051
59MP0001663_abnormal_digestive_system1.31501075
60MP0000647_abnormal_sebaceous_gland1.31306422
61MP0010771_integument_phenotype1.31046579
62MP0004381_abnormal_hair_follicle1.28850394
63MP0005381_digestive/alimentary_phenotyp1.27845993
64MP0004947_skin_inflammation1.25367191
65MP0005451_abnormal_body_composition1.22920689
66MP0000538_abnormal_urinary_bladder1.22471315
67MP0004782_abnormal_surfactant_physiolog1.21615865
68MP0005391_vision/eye_phenotype1.20130591
69MP0000465_gastrointestinal_hemorrhage1.19359145
70MP0003763_abnormal_thymus_physiology1.19130510
71MP0006054_spinal_hemorrhage1.17778103
72MP0002136_abnormal_kidney_physiology1.17659943
73MP0002452_abnormal_antigen_presenting1.17553687
74MP0009697_abnormal_copulation1.17441518
75MP0005025_abnormal_response_to1.15801800
76MP0002723_abnormal_immune_serum1.15662699
77MP0004270_analgesia1.13078839
78MP0002420_abnormal_adaptive_immunity1.12841131
79MP0001765_abnormal_ion_homeostasis1.11388950
80MP0000678_abnormal_parathyroid_gland1.11325182
81MP0001819_abnormal_immune_cell1.09460042
82MP0003191_abnormal_cellular_cholesterol1.09331140
83MP0002089_abnormal_postnatal_growth/wei1.07070076
84MP0002060_abnormal_skin_morphology1.05773816
85MP0004147_increased_porphyrin_level1.05664152
86MP0000230_abnormal_systemic_arterial1.04232468
87MP0009379_abnormal_foot_pigmentation1.01878711
88MP0000377_abnormal_hair_follicle1.01042324
89MP0002148_abnormal_hypersensitivity_rea1.00929996
90MP0005174_abnormal_tail_pigmentation1.00034113
91MP0003453_abnormal_keratinocyte_physiol0.99778220
92MP0000537_abnormal_urethra_morphology0.99223303
93MP0002822_catalepsy0.99094215
94MP0001881_abnormal_mammary_gland0.98511370
95MP0002229_neurodegeneration0.97480806
96MP0001963_abnormal_hearing_physiology0.96582817
97MP0000579_abnormal_nail_morphology0.95667890
98MP0005584_abnormal_enzyme/coenzyme_acti0.95185750
99MP0001664_abnormal_digestion0.95002629
100MP0001764_abnormal_homeostasis0.93873628
101MP0010386_abnormal_urinary_bladder0.90984246
102MP0001756_abnormal_urination0.90330781
103MP0005636_abnormal_mineral_homeostasis0.88822681
104MP0000427_abnormal_hair_cycle0.84612883
105MP0005084_abnormal_gallbladder_morpholo0.82558709
106MP0010352_gastrointestinal_tract_polyps0.79380386
107MP0000383_abnormal_hair_follicle0.78395440
108MP0001845_abnormal_inflammatory_respons0.74710512
109MP0001486_abnormal_startle_reflex0.74501153
110MP0003959_abnormal_lean_body0.74447646
111MP0001191_abnormal_skin_condition0.74051893
112MP0000566_synostosis0.72640885
113MP0000477_abnormal_intestine_morphology0.72513698
114MP0002277_abnormal_respiratory_mucosa0.71707761
115MP0002138_abnormal_hepatobiliary_system0.69592742
116MP0005166_decreased_susceptibility_to0.68743869
117MP0000762_abnormal_tongue_morphology0.68557826
118MP0003656_abnormal_erythrocyte_physiolo0.68355352
119MP0004084_abnormal_cardiac_muscle0.68165283
120MP0002118_abnormal_lipid_homeostasis0.67995071
121MP0001905_abnormal_dopamine_level0.67783554
122MP0001177_atelectasis0.66832249
123MP0008469_abnormal_protein_level0.66528535
124MP0002909_abnormal_adrenal_gland0.66219269
125MP0005410_abnormal_fertilization0.65781196
126MP0000367_abnormal_coat/_hair0.65369929
127MP0001835_abnormal_antigen_presentation0.64723182
128MP0000627_abnormal_mammary_gland0.62457041
129MP0005448_abnormal_energy_balance0.62420989
130MP0000716_abnormal_immune_system0.61916161
131MP0010155_abnormal_intestine_physiology0.61777950
132MP0008961_abnormal_basal_metabolism0.61112337
133MP0002653_abnormal_ependyma_morphology0.60568968
134MP0002933_joint_inflammation0.58516716
135MP0009384_cardiac_valve_regurgitation0.58259206
136MP0002752_abnormal_somatic_nervous0.57245072
137MP0005266_abnormal_metabolism0.54712179
138MP0004185_abnormal_adipocyte_glucose0.53896605
139MP0009931_abnormal_skin_appearance0.52132939
140MP0002282_abnormal_trachea_morphology0.51844496
141MP0001502_abnormal_circadian_rhythm0.51498072
142MP0003638_abnormal_response/metabolism_0.50607925
143MP0004885_abnormal_endolymph0.49800597
144MP0005187_abnormal_penis_morphology0.49703125
145MP0008872_abnormal_physiological_respon0.48636254
146MP0005365_abnormal_bile_salt0.47925144
147MP0001873_stomach_inflammation0.44824339
148MP0003718_maternal_effect0.43293723
149MP0005376_homeostasis/metabolism_phenot0.43158831
150MP0001849_ear_inflammation0.42586020
151MP0003283_abnormal_digestive_organ0.42055170
152MP0008789_abnormal_olfactory_epithelium0.40615627
153MP0000490_abnormal_crypts_of0.40255090
154MP0002638_abnormal_pupillary_reflex0.39234377

Predicted human phenotypes

RankGene SetZ-score
1Vitreoretinal degeneration (HP:0000655)8.27418620
2Pigmentary retinal degeneration (HP:0001146)8.07418345
3Dyschromatopsia (HP:0007641)7.95621883
4Oral leukoplakia (HP:0002745)7.94345672
5Absent rod-and cone-mediated responses on ERG (HP:0007688)7.17974728
6Congenital stationary night blindness (HP:0007642)6.56932048
7Abnormal rod and cone electroretinograms (HP:0008323)5.99465216
8Cupped ribs (HP:0000887)5.69575351
9Abnormality of macular pigmentation (HP:0008002)5.60403940
10Chorioretinal atrophy (HP:0000533)5.28360911
11Bony spicule pigmentary retinopathy (HP:0007737)5.27084483
12Increased IgE level (HP:0003212)5.20996744
13Central scotoma (HP:0000603)5.06482948
14Pendular nystagmus (HP:0012043)5.00870677
15Abolished electroretinogram (ERG) (HP:0000550)4.94265357
16Broad face (HP:0000283)4.76086032
17Ileus (HP:0002595)4.72086317
18Agammaglobulinemia (HP:0004432)4.59094779
19Hypoplastic ischia (HP:0003175)4.27768557
20Decreased central vision (HP:0007663)4.25637967
21Aplastic anemia (HP:0001915)4.23504794
22Posterior subcapsular cataract (HP:0007787)4.20958495
23Scotoma (HP:0000575)4.19052641
24Cone-rod dystrophy (HP:0000548)4.13421906
25Abnormality of glutamine family amino acid metabolism (HP:0010902)4.00138880
26Epiphyseal dysplasia (HP:0002656)4.00080598
27Eczematoid dermatitis (HP:0000976)3.96588553
28Macular degeneration (HP:0000608)3.93114787
29Autoimmune thrombocytopenia (HP:0001973)3.89558264
30Abnormality of the ischium (HP:0003174)3.72487748
31Recurrent pneumonia (HP:0006532)3.63583609
32Cellulitis (HP:0100658)3.60076657
33Malnutrition (HP:0004395)3.58478276
34Right ventricular cardiomyopathy (HP:0011663)3.56636326
35Cervical subluxation (HP:0003308)3.55189688
36Hypobetalipoproteinemia (HP:0003563)3.54085046
37Recurrent bronchitis (HP:0002837)3.51258664
38Photophobia (HP:0000613)3.44428672
39Irregular epiphyses (HP:0010582)3.43404272
40Congenital ichthyosiform erythroderma (HP:0007431)3.42930679
41Acanthocytosis (HP:0001927)3.42883175
42Abnormality of proline metabolism (HP:0010907)3.38896508
43Hydroxyprolinuria (HP:0003080)3.38896508
44Autoimmune hemolytic anemia (HP:0001890)3.32202363
45Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.31317946
46Oligodactyly (HP:0012165)3.24509467
47Cerebral palsy (HP:0100021)3.18977618
48Severe Myopia (HP:0011003)3.09507293
49Oligodactyly (hands) (HP:0001180)3.05915842
50Severe visual impairment (HP:0001141)3.05868586
51Attenuation of retinal blood vessels (HP:0007843)3.05030875
52Fibular aplasia (HP:0002990)2.99508907
53Chronic sinusitis (HP:0011109)2.98801952
54Verrucae (HP:0200043)2.97403258
55Papilloma (HP:0012740)2.97403258
56Type II diabetes mellitus (HP:0005978)2.95920768
57Split foot (HP:0001839)2.91519011
58Flattened epiphyses (HP:0003071)2.89920930
59Abnormality of macrophages (HP:0004311)2.85238511
60Alopecia of scalp (HP:0002293)2.81434670
61Flat acetabular roof (HP:0003180)2.77275814
62Abdominal distention (HP:0003270)2.75888607
63Radial bowing (HP:0002986)2.70029769
64Urticaria (HP:0001025)2.69608495
65Subcapsular cataract (HP:0000523)2.67547428
66Abnormality of the vitamin B12 metabolism (HP:0004341)2.63721953
67Sensory axonal neuropathy (HP:0003390)2.61428848
68Humeroradial synostosis (HP:0003041)2.60359730
69Synostosis involving the elbow (HP:0003938)2.60359730
70Decreased circulating renin level (HP:0003351)2.59235670
71Spastic paraparesis (HP:0002313)2.55844410
72Hyperactive renin-angiotensin system (HP:0000841)2.55025347
73Protuberant abdomen (HP:0001538)2.51049117
74Adactyly (HP:0009776)2.48639560
75Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.48509418
76Lower limb hyperreflexia (HP:0002395)2.47172680
77Recurrent lower respiratory tract infections (HP:0002783)2.44966049
78Recurrent gram-negative bacterial infections (HP:0005420)2.43315743
79Abnormality of vitamin B metabolism (HP:0004340)2.42817325
80J-shaped sella turcica (HP:0002680)2.41991613
81Hyperglycinuria (HP:0003108)2.40238398
82Mesangial abnormality (HP:0001966)2.40106071
83Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.39932420
84Hypoplastic pelvis (HP:0008839)2.39884490
85Gastrointestinal stroma tumor (HP:0100723)2.39387086
86Hypoplastic nipples (HP:0002557)2.39126540
87Abnormal tarsal ossification (HP:0008369)2.38767028
88Increased corneal curvature (HP:0100692)2.38515634
89Keratoconus (HP:0000563)2.38515634
90Conjugated hyperbilirubinemia (HP:0002908)2.38217235
91Pustule (HP:0200039)2.33583874
92Bronchitis (HP:0012387)2.33147756
93Congenital sensorineural hearing impairment (HP:0008527)2.32408981
94Sepsis (HP:0100806)2.31552234
95Corneal erosion (HP:0200020)2.28042692
96Choroideremia (HP:0001139)2.27638371
97Keratoconjunctivitis sicca (HP:0001097)2.22879464
98Woolly hair (HP:0002224)2.22370128
99Erythema (HP:0010783)2.21373028
100Recurrent bacterial skin infections (HP:0005406)2.21282666
101Skin rash (HP:0000988)2.20808608
102Obstructive lung disease (HP:0006536)2.20710297
103Chronic obstructive pulmonary disease (HP:0006510)2.20710297
104Aplasia/hypoplasia of the uterus (HP:0008684)2.19238968
105Abnormality of B cell number (HP:0010975)2.17827225
106B lymphocytopenia (HP:0010976)2.17827225
107Abnormal glucose tolerance (HP:0001952)2.17439901
108Hemorrhage of the eye (HP:0011885)2.16423755
109Poikilocytosis (HP:0004447)2.15057082
110Aplasia/hypoplasia of the femur (HP:0005613)2.14158516
111Amelogenesis imperfecta (HP:0000705)2.11549036
112Enlarged epiphyses (HP:0010580)2.10597186
113Tubular atrophy (HP:0000092)2.09918295
114Progressive visual loss (HP:0000529)2.08194120
115Dehydration (HP:0001944)2.07578280
116Plantar hyperkeratosis (HP:0007556)2.07329642
117Abnormality of renin-angiotensin system (HP:0000847)2.06961073
118Symphalangism affecting the phalanges of the hand (HP:0009773)2.06176511
119Obstructive sleep apnea (HP:0002870)2.05803740
120Abnormality of glycine metabolism (HP:0010895)2.05333547
121Abnormality of serine family amino acid metabolism (HP:0010894)2.05333547
122Poor speech (HP:0002465)2.03942234
123Keratoconjunctivitis (HP:0001096)2.00346654
124Fat malabsorption (HP:0002630)1.99915823
125Focal segmental glomerulosclerosis (HP:0000097)1.99494719
126Hypotrichosis (HP:0001006)1.99292196
127Meningitis (HP:0001287)1.98872870
128Lip pit (HP:0100267)1.98276494
129Xerostomia (HP:0000217)1.97221516
130Parakeratosis (HP:0001036)1.96811304
131Retinitis pigmentosa (HP:0000510)1.94981932
132Alkalosis (HP:0001948)1.94554425
133Aplasia involving forearm bones (HP:0009822)1.92571922
134Absent forearm bone (HP:0003953)1.92571922
135Flared iliac wings (HP:0002869)1.92116233
136Abnormal finger flexion creases (HP:0006143)1.92026069
137Hypolipoproteinemia (HP:0010981)1.91340095
138Hypoalbuminemia (HP:0003073)1.91183509
139Abnormal albumin level (HP:0012116)1.91183509
140Delayed epiphyseal ossification (HP:0002663)1.90889646
141Palmoplantar hyperkeratosis (HP:0000972)1.90219615
142Ventricular fibrillation (HP:0001663)1.88782778
143Aplasia/Hypoplasia of the clavicles (HP:0006710)1.88300445
144Glomerulosclerosis (HP:0000096)1.87882984
145Constricted visual fields (HP:0001133)1.86970027
146Dysostosis multiplex (HP:0000943)1.86700521
147Femoral bowing (HP:0002980)1.86456854
148Severe combined immunodeficiency (HP:0004430)1.86410220
149Palpebral edema (HP:0100540)1.85374820
150Recurrent skin infections (HP:0001581)1.84086276
151Increased IgM level (HP:0003496)1.82948802
152Pili torti (HP:0003777)1.81471298
153Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81057498
154Neonatal short-limb short stature (HP:0008921)1.81036230
155Unilateral renal agenesis (HP:0000122)1.79747243
156Hypohidrosis (HP:0000966)1.77794969
157Conjunctival hamartoma (HP:0100780)1.76679881
158Thyroiditis (HP:0100646)1.76201048
159Optic disc pallor (HP:0000543)1.75679285
160Polar cataract (HP:0010696)1.73893066
161Glycosuria (HP:0003076)1.72793462
162Abnormality of urine glucose concentration (HP:0011016)1.72793462
163Palmar hyperkeratosis (HP:0010765)1.70740660
164Abnormal foot bone ossification (HP:0010675)1.70598881
165Arthropathy (HP:0003040)1.68215222
166Genu varum (HP:0002970)1.66958277
167Anhidrosis (HP:0000970)1.66320082
168Osteoarthritis (HP:0002758)1.64528422
169Onycholysis (HP:0001806)1.63449219
170Curly hair (HP:0002212)1.59399875
171Fragile nails (HP:0001808)1.58339689
172Widely patent fontanelles and sutures (HP:0004492)1.58250887
173Abnormality of the vertebral endplates (HP:0005106)1.56520755
174Chronic diarrhea (HP:0002028)1.55608711
175Abnormality of nail color (HP:0100643)1.54062169
176Erythroderma (HP:0001019)1.52473700
177Long clavicles (HP:0000890)1.52425521
178Abnormal gallbladder physiology (HP:0012438)1.51667004
179Cholecystitis (HP:0001082)1.51667004
180Flat capital femoral epiphysis (HP:0003370)1.50143832

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.98115976
2MST1R5.16307490
3FRK4.66923338
4MST44.20451944
5MAP3K123.98100234
6TESK23.78533935
7IRAK43.75077075
8MAP3K33.62359057
9GRK13.25122511
10KDR3.20177605
11MAP3K22.97845677
12LMTK22.92773632
13DDR22.84511017
14NME12.72849689
15MET2.44181094
16MAP3K102.29993121
17BMPR22.25656551
18MAP3K62.25374568
19PRKG22.20899079
20TNIK2.19934254
21PASK2.11125284
22EPHB22.06641047
23CASK1.94651338
24EPHA21.88926808
25FGFR21.82080483
26ACVR1B1.81561569
27TYRO31.75068800
28IKBKE1.72736340
29ERN11.68552979
30SCYL21.68274888
31PTK61.66640087
32TESK11.65479251
33BCR1.60088352
34PIM21.59927654
35GRK61.58722445
36DAPK11.57822667
37FER1.49288161
38MAPK151.48975225
39MAP4K11.45474407
40PBK1.44476723
41NTRK21.33397506
42MYLK1.33078101
43NUAK11.26624018
44AKT31.25415114
45FGFR41.23678012
46MAP2K21.23529530
47ZAP701.22495616
48ERBB31.20373459
49DYRK1B1.20012481
50PKN11.16367227
51SYK1.12913203
52NLK1.10752623
53TAOK31.10577278
54BCKDK1.08355745
55RET1.08291455
56MAP3K41.05500450
57STK101.00804559
58MAP2K61.00512990
59CAMK2B0.99861497
60INSRR0.96623088
61ILK0.96488953
62OXSR10.96446061
63LYN0.95778547
64LIMK10.93096041
65TAOK10.92603086
66MAPK130.91762085
67DAPK30.91103957
68CAMK2G0.90739081
69RIPK10.90077414
70LATS10.89010225
71MATK0.89008136
72MAP3K70.88267995
73ERBB20.83901740
74ARAF0.80338300
75PRKCI0.79620078
76LRRK20.77065048
77KIT0.76695854
78TYK20.75862880
79PIK3CA0.75738459
80HIPK20.74651112
81STK390.74599908
82PINK10.74164124
83BLK0.73633267
84LCK0.73113853
85PRKD20.72331647
86MAP3K110.72272863
87CDK190.71927055
88WNK40.71254723
89RPS6KA40.70179317
90GRK70.68355220
91CSF1R0.65539864
92FGFR10.65453836
93ADRBK20.65111635
94PDGFRA0.63900920
95ICK0.63570018
96TAOK20.63026063
97FGFR30.61595725
98MAP3K10.61433893
99DMPK0.60666930
100CAMK2D0.59649278
101CAMKK10.56611776
102PTK20.56112674
103IKBKB0.56048271
104MELK0.54639512
105IRAK30.53570316
106IGF1R0.53509107
107MAP3K50.52500253
108FGR0.52431289
109CDK80.52322658
110ITK0.51826023
111PIM10.49397451
112DYRK1A0.48460295
113ADRBK10.47866399
114PRKAA20.46808507
115KSR20.46591843
116EPHB10.45460191
117GSK3A0.45239951
118CDK120.45046654
119SRC0.43021905
120MAP2K10.42483886
121TRPM70.42273806
122BRAF0.40276528
123CAMK10.39494937
124PRKD10.39325980
125TTK0.37984331
126STK240.37808068
127ROCK20.36614312
128PDGFRB0.35929648
129CAMKK20.35634811
130BMX0.35574819
131PAK30.35471633
132MAPK40.33386575
133PRKCB0.32988950
134CAMK2A0.32896116
135WNK10.32839637
136PRKCE0.32344184
137PRKACG0.32278041
138PRKG10.32221033
139MAP3K80.31529608
140PRKACA0.31417146
141CDK50.30452849
142PRKCQ0.30410490
143PRKCD0.30294401
144CDK90.29565517
145ERBB40.29508336
146PRKCZ0.29225067
147PIK3CG0.28435834
148MAPKAPK30.28434696
149ROCK10.28349100
150BRD40.26908216
151STK110.25389134
152MAPK70.25245011
153PRKCA0.24320266
154CSNK1D0.24313364
155CDC42BPA0.22413655
156CSK0.19933407
157FYN0.19608211
158CSNK1A1L0.19515301
159CDK60.18448181
160MAPK120.18346065
161MAPKAPK20.18271395

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.53225784
2Fat digestion and absorption_Homo sapiens_hsa049755.05402503
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.17943728
4Mineral absorption_Homo sapiens_hsa049783.89067549
5Primary immunodeficiency_Homo sapiens_hsa053403.34146911
6Vitamin digestion and absorption_Homo sapiens_hsa049772.87285255
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.81462286
8Renin-angiotensin system_Homo sapiens_hsa046142.56087563
9Caffeine metabolism_Homo sapiens_hsa002322.42884183
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.38954329
11Starch and sucrose metabolism_Homo sapiens_hsa005002.38479348
12Protein digestion and absorption_Homo sapiens_hsa049742.35187271
13Graft-versus-host disease_Homo sapiens_hsa053322.34165464
14Allograft rejection_Homo sapiens_hsa053302.34081981
15Autoimmune thyroid disease_Homo sapiens_hsa053202.26059702
16Folate biosynthesis_Homo sapiens_hsa007902.20503012
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.10852658
18Asthma_Homo sapiens_hsa053102.09889165
19Galactose metabolism_Homo sapiens_hsa000521.98727934
20Sphingolipid metabolism_Homo sapiens_hsa006001.98531819
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.95968381
22Antigen processing and presentation_Homo sapiens_hsa046121.86290639
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72843260
24Type I diabetes mellitus_Homo sapiens_hsa049401.70510542
25Bile secretion_Homo sapiens_hsa049761.66002261
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62731333
27Retinol metabolism_Homo sapiens_hsa008301.46746052
28Sulfur metabolism_Homo sapiens_hsa009201.44862430
29Hematopoietic cell lineage_Homo sapiens_hsa046401.36452624
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31799492
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31550298
32Fructose and mannose metabolism_Homo sapiens_hsa000511.30138266
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21900990
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.21061788
35Glycerolipid metabolism_Homo sapiens_hsa005611.20608474
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15665755
37Linoleic acid metabolism_Homo sapiens_hsa005911.15457535
38ABC transporters_Homo sapiens_hsa020101.13097611
39Rheumatoid arthritis_Homo sapiens_hsa053231.09768141
40Glutathione metabolism_Homo sapiens_hsa004801.03914230
41Staphylococcus aureus infection_Homo sapiens_hsa051501.03153743
42Proteasome_Homo sapiens_hsa030501.01013128
43Malaria_Homo sapiens_hsa051441.00790508
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00489670
45Histidine metabolism_Homo sapiens_hsa003400.97437533
46Arachidonic acid metabolism_Homo sapiens_hsa005900.96220102
47Viral myocarditis_Homo sapiens_hsa054160.93154538
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91193344
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84371824
50PPAR signaling pathway_Homo sapiens_hsa033200.83265299
51B cell receptor signaling pathway_Homo sapiens_hsa046620.83084282
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82792614
53Leishmaniasis_Homo sapiens_hsa051400.81871668
54Steroid biosynthesis_Homo sapiens_hsa001000.81383207
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80038420
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.80007775
57Tight junction_Homo sapiens_hsa045300.79264667
58Arginine biosynthesis_Homo sapiens_hsa002200.78534227
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78393177
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75904160
61Chemical carcinogenesis_Homo sapiens_hsa052040.75807467
62Oxidative phosphorylation_Homo sapiens_hsa001900.73700034
63Fatty acid elongation_Homo sapiens_hsa000620.73454318
64Ether lipid metabolism_Homo sapiens_hsa005650.71665176
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69981206
66Non-homologous end-joining_Homo sapiens_hsa034500.65112028
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61408168
68Parkinsons disease_Homo sapiens_hsa050120.61045200
69Thyroid hormone synthesis_Homo sapiens_hsa049180.60228754
70Sulfur relay system_Homo sapiens_hsa041220.59251482
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58730597
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57975128
73Phagosome_Homo sapiens_hsa041450.56632951
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.56435761
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56020709
76VEGF signaling pathway_Homo sapiens_hsa043700.53433409
77Fatty acid degradation_Homo sapiens_hsa000710.53307874
78Gastric acid secretion_Homo sapiens_hsa049710.52314624
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51120118
80Pancreatic secretion_Homo sapiens_hsa049720.50633155
81Arginine and proline metabolism_Homo sapiens_hsa003300.50437746
82Tuberculosis_Homo sapiens_hsa051520.50337285
83T cell receptor signaling pathway_Homo sapiens_hsa046600.49621046
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49089186
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48885101
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46814590
87Vibrio cholerae infection_Homo sapiens_hsa051100.46698570
88Insulin secretion_Homo sapiens_hsa049110.46535967
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45896413
90GnRH signaling pathway_Homo sapiens_hsa049120.45569403
91Nitrogen metabolism_Homo sapiens_hsa009100.45316945
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43806321
93Morphine addiction_Homo sapiens_hsa050320.43450747
94Synaptic vesicle cycle_Homo sapiens_hsa047210.43431927
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42820241
96Peroxisome_Homo sapiens_hsa041460.40324797
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39519273
98Pentose phosphate pathway_Homo sapiens_hsa000300.38506664
99Tryptophan metabolism_Homo sapiens_hsa003800.37951109
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.37466644
101Herpes simplex infection_Homo sapiens_hsa051680.36489866
102Serotonergic synapse_Homo sapiens_hsa047260.36470520
103Salivary secretion_Homo sapiens_hsa049700.36443903
104Olfactory transduction_Homo sapiens_hsa047400.36395369
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.36003903
106Cholinergic synapse_Homo sapiens_hsa047250.35667966
107Bladder cancer_Homo sapiens_hsa052190.35661439
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35337543
109Axon guidance_Homo sapiens_hsa043600.35266340
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35152050
111Ovarian steroidogenesis_Homo sapiens_hsa049130.34982463
112Shigellosis_Homo sapiens_hsa051310.34305321
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.33945758
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33835788
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.33759862
116Propanoate metabolism_Homo sapiens_hsa006400.33668047
117Adherens junction_Homo sapiens_hsa045200.33372721
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32633493
119Type II diabetes mellitus_Homo sapiens_hsa049300.31596493
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30349140
121TNF signaling pathway_Homo sapiens_hsa046680.30327411
122Pyruvate metabolism_Homo sapiens_hsa006200.30100442
123Long-term depression_Homo sapiens_hsa047300.29888726
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29726429
125Metabolic pathways_Homo sapiens_hsa011000.29233783
126Dopaminergic synapse_Homo sapiens_hsa047280.28998195
127Fatty acid biosynthesis_Homo sapiens_hsa000610.28328384
128Collecting duct acid secretion_Homo sapiens_hsa049660.28165538
129Phenylalanine metabolism_Homo sapiens_hsa003600.28103605
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26380669
131Renin secretion_Homo sapiens_hsa049240.25339515
132Choline metabolism in cancer_Homo sapiens_hsa052310.25171916
133Cardiac muscle contraction_Homo sapiens_hsa042600.24827795
134Nicotine addiction_Homo sapiens_hsa050330.22891848
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22340140
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.22292019
137Carbon metabolism_Homo sapiens_hsa012000.21262650
138Tyrosine metabolism_Homo sapiens_hsa003500.20883038
139Measles_Homo sapiens_hsa051620.20311752
140Salmonella infection_Homo sapiens_hsa051320.20173570
141Steroid hormone biosynthesis_Homo sapiens_hsa001400.20099833
142Glutamatergic synapse_Homo sapiens_hsa047240.19654973
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.18569602
144Cocaine addiction_Homo sapiens_hsa050300.18134583
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.17047452
146Circadian entrainment_Homo sapiens_hsa047130.16486311
147Biosynthesis of amino acids_Homo sapiens_hsa012300.15630336
148Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.14885877
149Hippo signaling pathway_Homo sapiens_hsa043900.14477154
150Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14313494
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.13829339
152Fatty acid metabolism_Homo sapiens_hsa012120.13715371
153Hepatitis C_Homo sapiens_hsa051600.12782091

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