OTOR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the melanoma-inhibiting activity gene family. The encoded protein is secreted via the Golgi apparatus and may function in cartilage development and maintenance. A frequent polymorphism in the translation start codon of this gene can abolish translation and may be associated with forms of deafness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)9.97727049
2axon regeneration (GO:0031103)9.95662116
3negative regulation of chemokine production (GO:0032682)9.90203979
4axon development (GO:0061564)7.86978689
5hyaluronan metabolic process (GO:0030212)7.60600155
6positive regulation of astrocyte differentiation (GO:0048711)7.48272870
7neuron projection regeneration (GO:0031102)7.31737893
8glycoprotein catabolic process (GO:0006516)7.28356095
9cell-cell junction maintenance (GO:0045217)7.15977795
10auditory receptor cell differentiation (GO:0042491)6.92248847
11regulation of gonadotropin secretion (GO:0032276)6.90987376
12regulation of cardioblast proliferation (GO:0003264)6.64903541
13regulation of secondary heart field cardioblast proliferation (GO:0003266)6.64903541
14regulation of response to osmotic stress (GO:0047484)6.31457813
15basement membrane organization (GO:0071711)6.15001095
16hypotonic response (GO:0006971)6.07560801
17regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033396.03695724
18regulation of T cell migration (GO:2000404)5.89208689
19hyperosmotic salinity response (GO:0042538)5.76946116
20enteric nervous system development (GO:0048484)5.71024584
21negative regulation of smooth muscle cell proliferation (GO:0048662)5.68443553
22cell junction maintenance (GO:0034331)5.57631923
23negative regulation of cell-matrix adhesion (GO:0001953)5.56204183
24cochlea morphogenesis (GO:0090103)5.55131555
25cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.40839959
26transmission of nerve impulse (GO:0019226)5.20449927
27lipopolysaccharide biosynthetic process (GO:0009103)5.07603546
28* sensory perception of sound (GO:0007605)5.04587934
29dorsal/ventral axis specification (GO:0009950)5.02315624
30collagen catabolic process (GO:0030574)5.02145835
31negative regulation of homotypic cell-cell adhesion (GO:0034111)4.99892876
32* sensory perception of mechanical stimulus (GO:0050954)4.96281780
33regulation of somitogenesis (GO:0014807)4.91759266
34collagen metabolic process (GO:0032963)4.90223877
35diterpenoid biosynthetic process (GO:0016102)4.87491782
36regulation of alkaline phosphatase activity (GO:0010692)4.82518140
37type B pancreatic cell proliferation (GO:0044342)4.81933201
38tissue regeneration (GO:0042246)4.80599840
39negative regulation of leukocyte migration (GO:0002686)4.79033624
40pentose metabolic process (GO:0019321)4.73213384
41outer ear morphogenesis (GO:0042473)4.67828035
42pattern specification involved in kidney development (GO:0061004)4.67451233
43regulation of extracellular matrix disassembly (GO:0010715)4.63339788
44multicellular organismal catabolic process (GO:0044243)4.60608672
45multicellular organismal macromolecule metabolic process (GO:0044259)4.59343163
46hair cell differentiation (GO:0035315)4.58145123
47regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.57780622
48chondroitin sulfate catabolic process (GO:0030207)4.54837273
49cellular response to vitamin D (GO:0071305)4.54044280
50inner ear receptor cell differentiation (GO:0060113)4.50610987
51regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.45462386
52establishment of tissue polarity (GO:0007164)4.44866933
53establishment of planar polarity (GO:0001736)4.44866933
54regulation of adherens junction organization (GO:1903391)4.41765140
55dermatan sulfate biosynthetic process (GO:0030208)4.41595322
56regulation of heart morphogenesis (GO:2000826)4.39225845
57regulation of focal adhesion assembly (GO:0051893)4.38658540
58regulation of cell-substrate junction assembly (GO:0090109)4.38658540
59lateral sprouting from an epithelium (GO:0060601)4.38075534
60regulation of cell proliferation involved in heart morphogenesis (GO:2000136)4.33770710
61dermatan sulfate metabolic process (GO:0030205)4.32086399
62type B pancreatic cell development (GO:0003323)4.31729709
63lung vasculature development (GO:0060426)4.31544349
64multicellular organismal metabolic process (GO:0044236)4.29951330
65lipopolysaccharide metabolic process (GO:0008653)4.29213872
66G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.25206758
67negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.25045693
68negative regulation of sodium ion transport (GO:0010766)4.13351097
69artery smooth muscle contraction (GO:0014824)4.11340179
70regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.08416519
71regulation of lymphocyte migration (GO:2000401)4.07851237
72response to axon injury (GO:0048678)4.05166289
73cell volume homeostasis (GO:0006884)4.01235406
74positive regulation of metanephros development (GO:0072216)3.97370186
75collagen fibril organization (GO:0030199)3.95550907
76positive regulation of osteoblast proliferation (GO:0033690)3.88577441
77negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.86790708
78planar cell polarity pathway involved in neural tube closure (GO:0090179)3.86375321
79positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.85677049
80regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.85677049
81glial cell migration (GO:0008347)3.82241427
82cellular response to prostaglandin stimulus (GO:0071379)3.80438050
83glycosphingolipid biosynthetic process (GO:0006688)3.73707507
84cAMP biosynthetic process (GO:0006171)3.73353144
85non-canonical Wnt signaling pathway (GO:0035567)3.72681716
86aorta morphogenesis (GO:0035909)3.72319775
87righting reflex (GO:0060013)3.71930648
88negative regulation of catenin import into nucleus (GO:0035414)3.70835963
89reflex (GO:0060004)3.69258907
90neural crest cell migration (GO:0001755)3.68657439
91face development (GO:0060324)3.67456887
92chondroitin sulfate biosynthetic process (GO:0030206)3.66538454
93endothelial cell morphogenesis (GO:0001886)3.63909769
94SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.63776872
95cellular sodium ion homeostasis (GO:0006883)3.62740861
96phasic smooth muscle contraction (GO:0014821)3.58105447
97tonic smooth muscle contraction (GO:0014820)3.57152646
98cell adhesion mediated by integrin (GO:0033627)3.56455076
99regulation of macrophage cytokine production (GO:0010935)3.56178839
100negative regulation of cell-substrate adhesion (GO:0010812)3.54873941
101regulation of timing of cell differentiation (GO:0048505)3.54013489
102mesenchyme morphogenesis (GO:0072132)3.52867013
103extracellular matrix disassembly (GO:0022617)3.51888682
104regulation of organ formation (GO:0003156)3.51643928
105regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.46976764
106melanocyte differentiation (GO:0030318)3.46123153
107peripheral nervous system development (GO:0007422)3.45584093
108mechanoreceptor differentiation (GO:0042490)3.45002340
109pigment cell differentiation (GO:0050931)3.44190996
110retinal metabolic process (GO:0042574)3.42870280
111phosphate ion transmembrane transport (GO:0035435)3.42235945
112midgut development (GO:0007494)3.41062837
113endocardial cushion morphogenesis (GO:0003203)3.39544024
114protein polyglutamylation (GO:0018095)3.38724457
115mucopolysaccharide metabolic process (GO:1903510)3.38121386
116positive regulation of hormone biosynthetic process (GO:0046886)3.35844983
117Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.35112789
118male genitalia development (GO:0030539)3.32398595
119glial cell proliferation (GO:0014009)3.32383759
120glandular epithelial cell development (GO:0002068)3.31823098
121mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.31720070
122terpenoid biosynthetic process (GO:0016114)3.29460874
123regulation of platelet aggregation (GO:0090330)3.28300660
124positive regulation of macrophage cytokine production (GO:0060907)3.26704304
125negative regulation of platelet activation (GO:0010544)3.23783525
126middle ear morphogenesis (GO:0042474)3.21786459
127gap junction assembly (GO:0016264)3.20151571
128negative regulation of chondrocyte differentiation (GO:0032331)3.17641409
129positive regulation of endothelial cell differentiation (GO:0045603)3.16490414
130digestive tract morphogenesis (GO:0048546)3.15865030
131positive regulation of protein depolymerization (GO:1901881)3.15180691
132regulation of development, heterochronic (GO:0040034)3.14532736
133inner ear morphogenesis (GO:0042472)3.13461010
134regulation of establishment of planar polarity (GO:0090175)3.13359864
135lung morphogenesis (GO:0060425)3.11896712
136convergent extension (GO:0060026)3.10391675
137retinoic acid receptor signaling pathway (GO:0048384)3.08223480
138cellular component maintenance (GO:0043954)3.07790082
139regulation of non-canonical Wnt signaling pathway (GO:2000050)3.07736928
140cellular response to vitamin (GO:0071295)3.07191353
141regulation of cell junction assembly (GO:1901888)3.05170417
142regulation of metanephros development (GO:0072215)3.03797687
143organ induction (GO:0001759)3.03458066
144detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.02994311
145pharyngeal system development (GO:0060037)2.98780842
146phosphate ion transport (GO:0006817)2.98755504
147regulation of chemokine-mediated signaling pathway (GO:0070099)2.98068632
148cardiac muscle cell proliferation (GO:0060038)2.96491287
149bone trabecula formation (GO:0060346)2.94950590
150positive regulation of gliogenesis (GO:0014015)2.94721413
151cartilage development (GO:0051216)2.92886127
152positive regulation of hormone metabolic process (GO:0032352)2.92220435
153negative regulation of cartilage development (GO:0061037)2.91676594
154nephron tubule formation (GO:0072079)2.90192101
155mesenchymal-epithelial cell signaling (GO:0060638)2.89464726
156tooth mineralization (GO:0034505)2.89345358
157positive regulation of bone resorption (GO:0045780)2.87917665
158positive regulation of bone remodeling (GO:0046852)2.87917665
159negative regulation of leukocyte chemotaxis (GO:0002689)2.85557766
160postsynaptic membrane organization (GO:0001941)2.84943432
161positive regulation of extracellular matrix organization (GO:1903055)2.83479960
162regulation of plasminogen activation (GO:0010755)2.82513649
163metanephros development (GO:0001656)2.82360930
164cell-matrix adhesion (GO:0007160)2.82159056
165microtubule polymerization or depolymerization (GO:0031109)2.80724198
166regulation of mesenchymal cell apoptotic process (GO:2001053)2.79636898
167pathway-restricted SMAD protein phosphorylation (GO:0060389)2.79515847
168regulation of corticosteroid hormone secretion (GO:2000846)2.76560077
169negative regulation of smooth muscle cell migration (GO:0014912)2.76555703
170embryonic eye morphogenesis (GO:0048048)2.75543904
171embryonic cranial skeleton morphogenesis (GO:0048701)2.73123446
172positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.73071321
173negative regulation of protein import into nucleus (GO:0042308)2.73058137
174glycosylceramide metabolic process (GO:0006677)2.72581041
175positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.71552465
176glycosaminoglycan metabolic process (GO:0030203)2.70112792
177regulation of transforming growth factor beta2 production (GO:0032909)2.69655988
178metanephric mesenchyme development (GO:0072075)2.68957741
179inositol phosphate-mediated signaling (GO:0048016)2.67851309
180branch elongation of an epithelium (GO:0060602)2.67774596
181chondrocyte differentiation (GO:0002062)2.67348655
182chondrocyte proliferation (GO:0035988)2.65041319
183regulation of lipoprotein metabolic process (GO:0050746)13.9006271
184negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)13.7129204
185regulation of cytokine production involved in inflammatory response (GO:1900015)13.6814584
186negative regulation of adherens junction organization (GO:1903392)12.8968698
187negative regulation of focal adhesion assembly (GO:0051895)12.8968698
188negative regulation of cell junction assembly (GO:1901889)12.8968698

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.13651958
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.43020692
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.66905176
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.11347369
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.09212598
6LXR_22292898_ChIP-Seq_THP-1_Human2.86050379
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.71126222
8ZNF263_19887448_ChIP-Seq_K562_Human2.46682601
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.46017863
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.31246527
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18673197
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.15834357
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.14000761
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03395986
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat11.4839348
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99220315
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99220315
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94565893
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93414595
20RACK7_27058665_Chip-Seq_MCF-7_Human1.92306860
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.91983316
22EP300_21415370_ChIP-Seq_HL-1_Mouse1.88941942
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.85110360
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.85091113
25TP53_22127205_ChIP-Seq_IMR90_Human1.80205058
26EZH2_22144423_ChIP-Seq_EOC_Human1.76883735
27CLOCK_20551151_ChIP-Seq_293T_Human1.76583255
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.75273924
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75146700
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70640001
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68931244
32GATA1_26923725_Chip-Seq_HPCs_Mouse1.67613461
33CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.64203800
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62551826
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.61571925
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.60898836
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60498027
38TET1_21451524_ChIP-Seq_MESCs_Mouse1.60410706
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59085901
40TP53_23651856_ChIP-Seq_MEFs_Mouse1.58087362
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57425568
42VDR_21846776_ChIP-Seq_THP-1_Human1.56930542
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.56081455
44ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.54350758
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54271466
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.53902200
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53176562
48STAT1_20625510_ChIP-Seq_HELA_Human1.49411122
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.46442546
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46165162
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44866073
52KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44866073
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44866073
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.44734016
55CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.43586306
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43072389
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43072389
58TCF7_22412390_ChIP-Seq_EML_Mouse1.41117431
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40796386
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39413517
61AHR_22903824_ChIP-Seq_MCF-7_Human1.38984581
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.38707940
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.37745967
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36926033
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36720923
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.36134872
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32081698
68BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.31259509
69ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27627379
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25324412
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24149926
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23670688
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21708559
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21441145
75MITF_21258399_ChIP-Seq_MELANOMA_Human1.20106475
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19744081
77JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18883195
78POU5F1_16518401_ChIP-PET_MESCs_Mouse1.18232127
79SMC4_20622854_ChIP-Seq_HELA_Human1.18157549
80SOX11_22085726_ChIP-Seq_ESNs_Mouse1.17885633
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.17632609
82EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16864130
83JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.16737744
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15975094
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14326211
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13922940
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.13709640
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12908150
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12808315
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.11538638
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11418095
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10948628
93EZH2_27304074_Chip-Seq_ESCs_Mouse1.10869576
94TBX20_22080862_ChIP-Seq_HEART_Mouse1.09873915
95TBX20_22328084_ChIP-Seq_HEART_Mouse1.09873915
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09850126
97DROSHA_22980978_ChIP-Seq_HELA_Human1.09291337
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06698507
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06595384
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06216993
101TP53_20018659_ChIP-ChIP_R1E_Mouse1.05256710
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.04649910
103* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04053476
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03633644
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03305498
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01399301
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.00846503
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00317913
109ISL1_27105846_Chip-Seq_CPCs_Mouse0.99899450
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99638304
111SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98734187
112HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98234339
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98069645
114TP53_18474530_ChIP-ChIP_U2OS_Human0.97321703
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97096786
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96591476
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96546346
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96354947
119OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96348072
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96179848
121IGF1R_20145208_ChIP-Seq_DFB_Human0.95889782
122CTCF_26484167_Chip-Seq_Bcells_Mouse0.95628558
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94697826
124ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94584217
125SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93427369
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92724258
127ESR1_20079471_ChIP-ChIP_T-47D_Human0.90499906
128* SOX2_21211035_ChIP-Seq_LN229_Gbm0.90354958
129CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89122248
130SOX2_20726797_ChIP-Seq_SW620_Human0.89090695
131STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88982769
132NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88327135
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87161735
134IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85844259
135TAF15_26573619_Chip-Seq_HEK293_Human0.84939859
136* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84371561
137ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82645552
138TCF4_18268006_ChIP-ChIP_LS174T_Human0.82399740
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82149869
140NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82149869
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81239482
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81114182
143TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81023352
144RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80851363
145P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78862825
146RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78720075
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78188754
148DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77541724
149LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76165537
150EOMES_21245162_ChIP-Seq_HESCs_Human0.76089282
151FOXO3_23340844_ChIP-Seq_DLD1_Human0.75975071
152KDM2B_26808549_Chip-Seq_K562_Human0.75952047
153VDR_24787735_ChIP-Seq_THP-1_Human0.75662139
154NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.74202720
155SMC1_22415368_ChIP-Seq_MEFs_Mouse0.73427501
156CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.73222487
157UBF1/2_26484160_Chip-Seq_HMECs_Human0.73142920
158NFIB_24661679_ChIP-Seq_LUNG_Mouse0.72768104
159GATA3_24758297_ChIP-Seq_MCF-7_Human0.72321823
160RUNX1_27514584_Chip-Seq_MCF-7_Human0.71964458

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003879_abnormal_hair_cell9.90340823
2MP0002822_catalepsy7.73819792
3MP0005171_absent_coat_pigmentation5.67435147
4MP0001963_abnormal_hearing_physiology4.75558522
5MP0000026_abnormal_inner_ear4.63815359
6MP0001485_abnormal_pinna_reflex4.17896704
7MP0005075_abnormal_melanosome_morpholog4.08002238
8MP0005248_abnormal_Harderian_gland3.64347480
9MP0003878_abnormal_ear_physiology3.58135507
10MP0005377_hearing/vestibular/ear_phenot3.58135507
11MP0004885_abnormal_endolymph3.49399222
12MP0004381_abnormal_hair_follicle3.13352043
13MP0003942_abnormal_urinary_system2.39755714
14MP0002751_abnormal_autonomic_nervous2.36750057
15MP0000534_abnormal_ureter_morphology2.23093856
16MP0003705_abnormal_hypodermis_morpholog2.18790539
17MP0008438_abnormal_cutaneous_collagen2.13856499
18MP0000920_abnormal_myelination2.06523285
19MP0010030_abnormal_orbit_morphology2.04659788
20MP0003941_abnormal_skin_development2.00391321
21MP0010234_abnormal_vibrissa_follicle1.96086712
22MP0003091_abnormal_cell_migration1.89718037
23MP0000049_abnormal_middle_ear1.87294475
24MP0009780_abnormal_chondrocyte_physiolo1.86267300
25MP0005623_abnormal_meninges_morphology1.73802142
26MP0005058_abnormal_lysosome_morphology1.73482674
27MP0004134_abnormal_chest_morphology1.68279815
28MP0002249_abnormal_larynx_morphology1.67018136
29MP0002933_joint_inflammation1.65387358
30MP0002233_abnormal_nose_morphology1.64461900
31MP0010678_abnormal_skin_adnexa1.63529689
32MP0001348_abnormal_lacrimal_gland1.62652566
33MP0004036_abnormal_muscle_relaxation1.62607602
34MP0005275_abnormal_skin_tensile1.61030631
35MP0003634_abnormal_glial_cell1.60253875
36MP0003938_abnormal_ear_development1.59173146
37MP0009384_cardiac_valve_regurgitation1.59014800
38MP0009053_abnormal_anal_canal1.58464699
39MP0002735_abnormal_chemical_nociception1.57935205
40MP0001849_ear_inflammation1.56350065
41MP0004272_abnormal_basement_membrane1.56202098
42MP0003045_fibrosis1.56194299
43MP0003123_paternal_imprinting1.52486403
44MP0005508_abnormal_skeleton_morphology1.50159979
45MP0000566_synostosis1.45511324
46MP0001346_abnormal_lacrimal_gland1.41896358
47MP0005503_abnormal_tendon_morphology1.40432374
48MP0004742_abnormal_vestibular_system1.39963705
49MP0000383_abnormal_hair_follicle1.39385747
50MP0002282_abnormal_trachea_morphology1.35361105
51MP0002932_abnormal_joint_morphology1.35306303
52MP0002272_abnormal_nervous_system1.35213470
53MP0000163_abnormal_cartilage_morphology1.34346264
54MP0000762_abnormal_tongue_morphology1.33273635
55MP0001299_abnormal_eye_distance/1.30492675
56MP0002837_dystrophic_cardiac_calcinosis1.30138084
57MP0000579_abnormal_nail_morphology1.29257387
58MP0000537_abnormal_urethra_morphology1.28244978
59MP0003279_aneurysm1.26420849
60MP0003633_abnormal_nervous_system1.25206135
61MP0009765_abnormal_xenobiotic_induced1.24053784
62MP0004510_myositis1.22965019
63MP0002108_abnormal_muscle_morphology1.22820987
64MP0002102_abnormal_ear_morphology1.16195664
65MP0002116_abnormal_craniofacial_bone1.13975220
66MP0002115_abnormal_skeleton_extremities1.12816632
67MP0004264_abnormal_extraembryonic_tissu1.11296209
68MP0005330_cardiomyopathy1.10883120
69MP0002098_abnormal_vibrissa_morphology1.07859157
70MP0005367_renal/urinary_system_phenotyp1.05135495
71MP0000516_abnormal_urinary_system1.05135495
72MP0005023_abnormal_wound_healing1.03323285
73MP0001501_abnormal_sleep_pattern1.03136821
74MP0003566_abnormal_cell_adhesion1.02035356
75MP0001243_abnormal_dermal_layer1.00595385
76MP0003315_abnormal_perineum_morphology0.98767769
77MP0009250_abnormal_appendicular_skeleto0.98639842
78MP0000428_abnormal_craniofacial_morphol0.97776833
79MP0003631_nervous_system_phenotype0.95539057
80MP0002998_abnormal_bone_remodeling0.93174278
81MP0008873_increased_physiological_sensi0.90093671
82MP0005408_hypopigmentation0.89010442
83MP0002089_abnormal_postnatal_growth/wei0.88058671
84MP0005390_skeleton_phenotype0.87717885
85MP0001286_abnormal_eye_development0.87291363
86MP0003011_delayed_dark_adaptation0.86636081
87MP0001533_abnormal_skeleton_physiology0.84478155
88MP0008789_abnormal_olfactory_epithelium0.83793434
89MP0001958_emphysema0.83639629
90MP0000613_abnormal_salivary_gland0.83250345
91MP0002009_preneoplasia0.83185032
92MP0002111_abnormal_tail_morphology0.82493972
93MP0003119_abnormal_digestive_system0.82087354
94MP0001486_abnormal_startle_reflex0.81056955
95MP0000733_abnormal_muscle_development0.80558193
96MP0002896_abnormal_bone_mineralization0.79364608
97MP0002234_abnormal_pharynx_morphology0.78742521
98MP0002113_abnormal_skeleton_development0.76923500
99MP0003935_abnormal_craniofacial_develop0.74631218
100MP0004858_abnormal_nervous_system0.74405354
101MP0002938_white_spotting0.73387876
102MP0005451_abnormal_body_composition0.72705050
103MP0002177_abnormal_outer_ear0.72139863
104MP0003755_abnormal_palate_morphology0.70244038
105MP0002877_abnormal_melanocyte_morpholog0.69697980
106MP0003329_amyloid_beta_deposits0.68849839
107MP0000604_amyloidosis0.68069398
108MP0008569_lethality_at_weaning0.67930262
109MP0002109_abnormal_limb_morphology0.66876961
110MP0005595_abnormal_vascular_smooth0.66570007
111MP0004043_abnormal_pH_regulation0.65205819
112MP0003567_abnormal_fetal_cardiomyocyte0.64273852
113MP0001340_abnormal_eyelid_morphology0.63634287
114MP0000432_abnormal_head_morphology0.62322544
115MP0000858_altered_metastatic_potential0.62316317
116MP0003795_abnormal_bone_structure0.62127920
117MP0002752_abnormal_somatic_nervous0.62043504
118MP0003385_abnormal_body_wall0.61992590
119MP0003283_abnormal_digestive_organ0.61448250
120MP0001293_anophthalmia0.58549697
121MP0005164_abnormal_response_to0.58212653
122MP0001614_abnormal_blood_vessel0.57931007
123MP0003115_abnormal_respiratory_system0.57806677
124MP0006054_spinal_hemorrhage0.56732626
125MP0008770_decreased_survivor_rate0.55307208
126MP0002277_abnormal_respiratory_mucosa0.55180507
127MP0001270_distended_abdomen0.54136847
128MP0003252_abnormal_bile_duct0.53326094
129MP0004859_abnormal_synaptic_plasticity0.53195906
130MP0002067_abnormal_sensory_capabilities0.52910009
131MP0010771_integument_phenotype0.52859481
132MP0005187_abnormal_penis_morphology0.52366261
133MP0001502_abnormal_circadian_rhythm0.51482751
134MP0002092_abnormal_eye_morphology0.51143780
135MP0002184_abnormal_innervation0.50540470
136MP0002796_impaired_skin_barrier0.49644776
137MP0000759_abnormal_skeletal_muscle0.49593993
138MP0002060_abnormal_skin_morphology0.49137771
139MP0000751_myopathy0.48296120
140MP0000462_abnormal_digestive_system0.47986668
141MP0004084_abnormal_cardiac_muscle0.47428235
142MP0001905_abnormal_dopamine_level0.47406197
143MP0002254_reproductive_system_inflammat0.47353964
144MP0000639_abnormal_adrenal_gland0.45587834
145MP0000358_abnormal_cell_content/0.44577332
146MP0002063_abnormal_learning/memory/cond0.44157181
147MP0002114_abnormal_axial_skeleton0.43422679
148MP0009763_increased_sensitivity_to0.43200557
149MP0002066_abnormal_motor_capabilities/c0.42392119
150MP0001915_intracranial_hemorrhage0.41392700
151MP0005620_abnormal_muscle_contractility0.39931034
152MP0001727_abnormal_embryo_implantation0.39515053
153MP0002168_other_aberrant_phenotype0.38894792
154MP0000627_abnormal_mammary_gland0.38483119
155MP0002972_abnormal_cardiac_muscle0.37888156
156MP0009931_abnormal_skin_appearance0.36170428
157MP0004085_abnormal_heartbeat0.36149728

Predicted human phenotypes

RankGene SetZ-score
1Vitreoretinal degeneration (HP:0000655)9.03067503
2Severe Myopia (HP:0011003)8.48125100
3Peripheral hypomyelination (HP:0007182)8.34145686
4Irregular epiphyses (HP:0010582)7.62149853
5Hand muscle atrophy (HP:0009130)6.99885025
6Mild short stature (HP:0003502)6.86941469
7Hypoplastic ischia (HP:0003175)6.79882673
8Stridor (HP:0010307)6.75362700
9Aplasia/Hypoplasia of the pubic bone (HP:0009104)6.69690794
10Upper limb muscle weakness (HP:0003484)6.21091304
11Abnormality of the ischium (HP:0003174)6.00200678
12Distal upper limb amyotrophy (HP:0007149)5.88002384
13Upper limb amyotrophy (HP:0009129)5.88002384
14Mixed hearing impairment (HP:0000410)5.42233606
15White forelock (HP:0002211)5.27612719
16Abnormality of the vitreous humor (HP:0004327)5.10547463
17Abnormality of the distal phalanges of the toes (HP:0010182)4.89967177
18Ulnar claw (HP:0001178)4.88909590
19Distal lower limb muscle weakness (HP:0009053)4.88496102
20Osteoarthritis (HP:0002758)4.84908743
21Patchy hypopigmentation of hair (HP:0011365)4.75519869
22Genu varum (HP:0002970)4.71743344
23Bell-shaped thorax (HP:0001591)4.67322878
24Termporal pattern (HP:0011008)4.64647736
25Insidious onset (HP:0003587)4.64647736
26Flattened epiphyses (HP:0003071)4.52944380
27Diaphragmatic weakness (HP:0009113)4.40304002
28Small epiphyses (HP:0010585)4.39953473
29J-shaped sella turcica (HP:0002680)4.39202745
30Aplasia of the musculature (HP:0100854)4.36192135
31Abnormal pupillary function (HP:0007686)4.30849950
32Segmental peripheral demyelination/remyelination (HP:0003481)4.12905885
33Enlarged epiphyses (HP:0010580)3.98446030
34Action tremor (HP:0002345)3.98233320
35Abnormality of the pubic bones (HP:0003172)3.96660533
36Hypoventilation (HP:0002791)3.87498630
37Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.79952577
38Absent epiphyses (HP:0010577)3.79952577
39Vertebral clefting (HP:0008428)3.79732282
40Limb-girdle muscle atrophy (HP:0003797)3.76257424
41Spinal muscular atrophy (HP:0007269)3.75113429
42Carpal bone hypoplasia (HP:0001498)3.71859787
43Fetal akinesia sequence (HP:0001989)3.71323059
44Obstructive sleep apnea (HP:0002870)3.70733116
45Cerebral aneurysm (HP:0004944)3.65988308
46Arterial tortuosity (HP:0005116)3.61937375
47Ulnar bowing (HP:0003031)3.59872369
48Muscle fiber splitting (HP:0003555)3.56321573
49Morphological abnormality of the middle ear (HP:0008609)3.50530101
50Delayed epiphyseal ossification (HP:0002663)3.48492220
51Glossoptosis (HP:0000162)3.46432502
52Protuberant abdomen (HP:0001538)3.44355394
53Lip pit (HP:0100267)3.43533918
54Morphological abnormality of the inner ear (HP:0011390)3.40305966
55Heterochromia iridis (HP:0001100)3.40185327
56Abnormality of the fetal cardiovascular system (HP:0010948)3.39832720
57Abnormal umbilical cord blood vessels (HP:0011403)3.39832720
58Single umbilical artery (HP:0001195)3.39832720
59Exostoses (HP:0100777)3.35412963
60Platyspondyly (HP:0000926)3.32049502
61Flat acetabular roof (HP:0003180)3.31205824
62Abnormality of the umbilical cord (HP:0010881)3.19724469
63Vascular tortuosity (HP:0004948)3.19591921
64Spinal cord compression (HP:0002176)3.17311446
65Hypoplasia of the capital femoral epiphysis (HP:0003090)3.16711893
66Recurrent corneal erosions (HP:0000495)3.14927466
67Abnormal auditory evoked potentials (HP:0006958)2.97911908
68Abnormality of the middle phalanges of the toes (HP:0010183)2.97857040
69Foot dorsiflexor weakness (HP:0009027)2.89743942
70Cervical subluxation (HP:0003308)2.79035006
71Protrusio acetabuli (HP:0003179)2.76360133
72Blue irides (HP:0000635)2.75959967
73Micromelia (HP:0002983)2.72138995
74Nonprogressive disorder (HP:0003680)2.70384199
75Abnormality of the musculature of the hand (HP:0001421)2.68179540
76Abnormality of the foot musculature (HP:0001436)2.64636555
77Hammertoe (HP:0001765)2.60505041
78Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.58698307
79Abnormality of the vertebral endplates (HP:0005106)2.53502417
80Synostosis of carpal bones (HP:0005048)2.51508834
81Alopecia of scalp (HP:0002293)2.51094675
82Coxa vara (HP:0002812)2.49842727
83Impaired proprioception (HP:0010831)2.49622704
84Hypoplasia of the uterus (HP:0000013)2.47215632
85Sprengel anomaly (HP:0000912)2.46812721
86Deformed sella turcica (HP:0002681)2.44512722
87Aplasia/Hypoplasia involving the musculature (HP:0001460)2.42115277
88Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.40388711
89Dislocated radial head (HP:0003083)2.40102654
90Spinal rigidity (HP:0003306)2.36682666
91Cerebral hypomyelination (HP:0006808)2.36211066
92Premature graying of hair (HP:0002216)2.34753660
93Unilateral renal agenesis (HP:0000122)2.32247072
94Onion bulb formation (HP:0003383)2.30588287
95Postural tremor (HP:0002174)2.27920211
96Retinopathy (HP:0000488)2.27603523
97Abnormality of the vocal cords (HP:0008777)2.27211009
98Achilles tendon contracture (HP:0001771)2.25589793
99Abnormality of the radial head (HP:0003995)2.23993234
100Abnormality of the intervertebral disk (HP:0005108)2.22443571
101Abnormality of carpal bone ossification (HP:0006257)2.22180290
102Increased CSF protein (HP:0002922)2.21932722
103Broad metatarsal (HP:0001783)2.19777061
104Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.18693857
105Peripheral demyelination (HP:0011096)2.17694717
106Premature rupture of membranes (HP:0001788)2.16128142
107Hypoplasia of the iris (HP:0007676)2.15850258
108Spastic paraparesis (HP:0002313)2.15466961
109Thin ribs (HP:0000883)2.15349804
110Slender long bone (HP:0003100)2.15043518
111Stenosis of the external auditory canal (HP:0000402)2.14717133
112Breast aplasia (HP:0100783)2.13423528
113Absent eyelashes (HP:0000561)2.13309933
114Genu valgum (HP:0002857)2.11885291
115Rough bone trabeculation (HP:0100670)2.09998166
116Disproportionate short-trunk short stature (HP:0003521)2.07189951
117Potter facies (HP:0002009)2.06219418
118Facial shape deformation (HP:0011334)2.06219418
119Hypoplasia of the odontoid process (HP:0003311)2.05325711
120Down-sloping shoulders (HP:0200021)2.01775592
121Rhizomelia (HP:0008905)2.01620549
122Bowed forearm bones (HP:0003956)2.01610338
123Bowing of the arm (HP:0006488)2.01610338
124Abnormal vertebral ossification (HP:0100569)2.01588849
125Underdeveloped nasal alae (HP:0000430)2.01452002
126Abnormality of the Achilles tendon (HP:0005109)2.00029103
127Epiphyseal dysplasia (HP:0002656)13.9429586
128Torticollis (HP:0000473)1.98601750
129Short palm (HP:0004279)1.96487996
130Abnormality of the calf musculature (HP:0001430)1.94124888
131Flared metaphyses (HP:0003015)1.93607315
132Short femoral neck (HP:0100864)1.93598934
133Mildly elevated creatine phosphokinase (HP:0008180)1.93457212
134Narrow nasal bridge (HP:0000446)1.90041223
135Long toe (HP:0010511)1.89171836
136Generalized amyotrophy (HP:0003700)1.89130501
137Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.88418663
138Shallow orbits (HP:0000586)1.86061436
139Renal dysplasia (HP:0000110)1.85745243
140Preauricular skin tag (HP:0000384)1.83005617
141Bulbous nose (HP:0000414)1.81889767
142Multifactorial inheritance (HP:0001426)1.81084720
143Carpal synostosis (HP:0009702)1.80587685
144Knee flexion contracture (HP:0006380)1.75210623
145Spondylolisthesis (HP:0003302)1.72756922
146Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.69225097
147Progressive sensorineural hearing impairment (HP:0000408)1.68559869
148Hypoplastic labia majora (HP:0000059)1.66974421
149Arthralgia (HP:0002829)1.64321111
150Abnormality of dentin (HP:0010299)1.60943352
151Oral leukoplakia (HP:0002745)1.59489377
152Skin tags (HP:0010609)1.58804277
153Aortic dissection (HP:0002647)1.58167908
154Autoamputation (HP:0001218)1.56509195
155Abdominal distention (HP:0003270)1.56505945
156Amniotic constriction ring (HP:0009775)1.56085869
157Abnormality of placental membranes (HP:0011409)1.56085869
158Congenital, generalized hypertrichosis (HP:0004540)1.55189512
159Retinal detachment (HP:0000541)1.53817715
160Alacrima (HP:0000522)1.53394379
161Abnormality of the 2nd finger (HP:0004100)1.51504712
162Synostosis involving the elbow (HP:0003938)1.51270930
163Humeroradial synostosis (HP:0003041)1.51270930
164Hypotrichosis (HP:0001006)1.50980416
165Preauricular pit (HP:0004467)1.50233456
166Periauricular skin pits (HP:0100277)1.50233456
167Bilateral microphthalmos (HP:0007633)1.49042362
168Pterygium (HP:0001059)1.48298366
169Plagiocephaly (HP:0001357)1.46864178
170Abnormality of the labia majora (HP:0012881)1.46093861
171Synostosis involving bones of the hand (HP:0004278)1.45286647
172Hip dysplasia (HP:0001385)1.44545823
173Hydroxyprolinuria (HP:0003080)1.38931749
174Abnormality of proline metabolism (HP:0010907)1.38931749
175Lumbar hyperlordosis (HP:0002938)1.38499111
176Abnormality of the salivary glands (HP:0010286)1.36142879
177Pectus carinatum (HP:0000768)1.36120038
178Subacute progressive viral hepatitis (HP:0006572)1.35319858
179Short ribs (HP:0000773)1.34598117
180Abnormality of nail color (HP:0100643)1.34366279
181Hypoplastic ilia (HP:0000946)1.33053309
182Renal duplication (HP:0000075)1.32160195
183Midface retrusion (HP:0011800)1.32136868
184Elbow flexion contracture (HP:0002987)1.31292671
185Skin pits (HP:0100276)1.30955475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.66442321
2ERBB46.29153338
3MOS4.01925764
4TRIB33.17786615
5MUSK3.07442377
6LATS12.91671200
7PKN22.56942760
8TRPM72.43085636
9STK392.12582574
10EPHA32.01813963
11DDR213.1343896
12NTRK11.89007040
13PRKD21.61639451
14WNK41.53833701
15AKT31.52693493
16MAP3K31.46313796
17RIPK11.40854990
18ERBB31.36468402
19DYRK1B1.35813605
20PTK61.35516723
21PDGFRA1.31906636
22MKNK21.30813833
23LIMK11.29464327
24DAPK11.23080558
25LRRK21.18983686
26KSR21.18702723
27PAK41.13908933
28ICK1.09939793
29MAP3K101.09424281
30EPHB11.07039594
31MAP3K111.06606310
32PAK61.04306355
33PAK31.02544469
34ZAP701.00542289
35CDK61.00005468
36BRSK10.96805635
37UHMK10.96464306
38EPHB20.89298884
39LATS20.89244293
40MET0.85021803
41ILK0.82990006
42LMTK20.81373045
43CSK0.81127724
44STK30.80830857
45WNK10.80699270
46SIK10.80520679
47CSNK1G10.80180796
48CSNK1A1L0.78579642
49PLK20.75156141
50CSNK1G20.74692987
51FER0.73537949
52BMPR20.72282524
53MAP3K90.72059126
54MAP3K60.72008517
55PAK10.68230967
56CSNK1G30.67821854
57KSR10.67750921
58FGFR10.67741596
59FGFR40.67642679
60NLK0.65333346
61RET0.64633255
62MAP3K20.64553113
63FLT30.63962574
64ERBB20.63134567
65MARK30.61339830
66CDK150.61016014
67PAK20.59550440
68DAPK20.58089970
69CDK180.56488176
70CDK11A0.55575718
71ROCK20.55383991
72NTRK30.54700721
73CDC42BPA0.54700586
74TESK20.54506544
75BMX0.50110262
76TIE10.49925466
77NEK20.49357206
78CLK10.48550384
79ROCK10.48011375
80PRKD30.47974448
81GRK60.47171527
82TAOK20.44213632
83PTK2B0.43714899
84MKNK10.43622713
85PTK20.43050642
86MINK10.41328583
87PRKCH0.40839130
88MAP2K10.38314460
89FGFR20.38063124
90ABL20.37822461
91CDK50.37714760
92ARAF0.37566532
93TGFBR20.36042043
94MST1R0.35841536
95MAP2K30.35156031
96YES10.34574109
97CDK190.32958881
98PDGFRB0.32550619
99PRKCZ0.32514505
100PIM20.32331158
101PRKCE0.31606000
102OXSR10.31365108
103PHKG20.31226030
104PHKG10.31226030
105STK160.30905531
106PRKCD0.30859205
107SIK30.30833993
108MAP3K130.29960695
109FYN0.29842039
110MAPKAPK30.28369204
111MAP3K70.28084954
112PDK10.27763666
113RIPK40.27199679
114HIPK20.26592876
115SCYL20.26164602
116EEF2K0.25539849
117JAK20.25429867
118GSK3A0.24219555
119TESK10.24208864
120DAPK30.23723648
121NUAK10.23294485
122CAMKK10.23257760
123TYRO30.22882213
124PKN10.22386644
125PDPK10.21705521
126CDK140.21072457
127TGFBR10.20601537
128MARK20.20211918
129ABL10.19979582
130PRKCG0.19550460
131SRC0.19098615
132RAF10.18998359
133ERN10.18989197
134MAP2K40.18453958
135TTN0.18239127
136CDK30.17624150
137MAP3K120.17520044
138EPHA20.17011527
139BTK0.16955656
140ALK0.16932145
141HCK0.16744741
142MAP3K10.16140153
143MAPKAPK20.14498422
144MAPK70.13663197
145VRK20.13585803
146MAPK110.13032833
147CCNB10.12285894
148MAPK10.11635530
149IGF1R0.11310431
150SGK10.10759984
151MTOR0.10227093
152JAK30.10074200
153PRKDC0.09262103

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein digestion and absorption_Homo sapiens_hsa049744.18796075
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.98053744
3ECM-receptor interaction_Homo sapiens_hsa045123.90470662
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.63055765
5Basal cell carcinoma_Homo sapiens_hsa052173.00259004
6Hippo signaling pathway_Homo sapiens_hsa043902.70184534
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.69853838
8Other glycan degradation_Homo sapiens_hsa005112.13469896
9Wnt signaling pathway_Homo sapiens_hsa043102.13106166
10Focal adhesion_Homo sapiens_hsa045102.06646650
11Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.05498343
12Histidine metabolism_Homo sapiens_hsa003401.93496023
13TGF-beta signaling pathway_Homo sapiens_hsa043501.92988005
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.81638402
15Phenylalanine metabolism_Homo sapiens_hsa003601.78003045
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.71427405
17Proteoglycans in cancer_Homo sapiens_hsa052051.66495851
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.65058848
19Melanogenesis_Homo sapiens_hsa049161.61332411
20Nitrogen metabolism_Homo sapiens_hsa009101.60971016
21Dorso-ventral axis formation_Homo sapiens_hsa043201.59323411
22Hedgehog signaling pathway_Homo sapiens_hsa043401.56531679
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.55351544
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49303713
25beta-Alanine metabolism_Homo sapiens_hsa004101.48979159
26Sphingolipid metabolism_Homo sapiens_hsa006001.35659295
27Colorectal cancer_Homo sapiens_hsa052101.29634707
28African trypanosomiasis_Homo sapiens_hsa051431.25464123
29Fatty acid biosynthesis_Homo sapiens_hsa000611.21811256
30Axon guidance_Homo sapiens_hsa043601.19713268
31Sulfur relay system_Homo sapiens_hsa041221.19061336
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18948737
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18203017
34Chronic myeloid leukemia_Homo sapiens_hsa052201.10888183
35Lysosome_Homo sapiens_hsa041421.07773916
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06791536
37N-Glycan biosynthesis_Homo sapiens_hsa005101.06236435
38Renal cell carcinoma_Homo sapiens_hsa052111.04358460
39Tight junction_Homo sapiens_hsa045301.03332331
40Lysine degradation_Homo sapiens_hsa003101.03171722
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01778161
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.01722806
43Dilated cardiomyopathy_Homo sapiens_hsa054141.01283232
44PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99542976
45Endometrial cancer_Homo sapiens_hsa052130.98591512
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94520291
47Amoebiasis_Homo sapiens_hsa051460.94119387
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93594407
49Adherens junction_Homo sapiens_hsa045200.90566896
50Linoleic acid metabolism_Homo sapiens_hsa005910.89390768
51Estrogen signaling pathway_Homo sapiens_hsa049150.86049852
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84591720
53Glioma_Homo sapiens_hsa052140.83279862
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82719365
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82449310
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81860810
57Fatty acid degradation_Homo sapiens_hsa000710.81546665
58Melanoma_Homo sapiens_hsa052180.78687773
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78386722
60Sulfur metabolism_Homo sapiens_hsa009200.74224929
61Bladder cancer_Homo sapiens_hsa052190.72865266
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70777814
63Malaria_Homo sapiens_hsa051440.70394334
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.66991553
65Ether lipid metabolism_Homo sapiens_hsa005650.66965629
66Pathways in cancer_Homo sapiens_hsa052000.65492924
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.65449743
68Prostate cancer_Homo sapiens_hsa052150.64160477
69ErbB signaling pathway_Homo sapiens_hsa040120.63500224
70Tyrosine metabolism_Homo sapiens_hsa003500.63280901
71Fatty acid metabolism_Homo sapiens_hsa012120.61413308
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59015619
73Notch signaling pathway_Homo sapiens_hsa043300.58997329
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.58568027
75Vibrio cholerae infection_Homo sapiens_hsa051100.57533565
76Pancreatic cancer_Homo sapiens_hsa052120.57512132
77Long-term depression_Homo sapiens_hsa047300.56763469
78Ovarian steroidogenesis_Homo sapiens_hsa049130.55928282
79Gap junction_Homo sapiens_hsa045400.55745655
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55739346
81VEGF signaling pathway_Homo sapiens_hsa043700.54562319
82Viral myocarditis_Homo sapiens_hsa054160.53888366
83Gastric acid secretion_Homo sapiens_hsa049710.53592758
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51889077
85Thyroid hormone synthesis_Homo sapiens_hsa049180.51770338
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51357245
87Toxoplasmosis_Homo sapiens_hsa051450.50960187
88Small cell lung cancer_Homo sapiens_hsa052220.50304468
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49232440
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48827392
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48413164
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48209296
93Butanoate metabolism_Homo sapiens_hsa006500.46790890
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.46781013
95GnRH signaling pathway_Homo sapiens_hsa049120.46202222
96Phagosome_Homo sapiens_hsa041450.45798025
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45707390
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45547906
99Dopaminergic synapse_Homo sapiens_hsa047280.45265016
100Ras signaling pathway_Homo sapiens_hsa040140.45024765
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44418273
102Cocaine addiction_Homo sapiens_hsa050300.44219294
103Rap1 signaling pathway_Homo sapiens_hsa040150.43980988
104Cholinergic synapse_Homo sapiens_hsa047250.43017175
105Choline metabolism in cancer_Homo sapiens_hsa052310.42898386
106Fat digestion and absorption_Homo sapiens_hsa049750.42585306
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41856900
108mTOR signaling pathway_Homo sapiens_hsa041500.40679620
109PPAR signaling pathway_Homo sapiens_hsa033200.40606661
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40421798
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40354512
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40306327
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40237765
114Non-small cell lung cancer_Homo sapiens_hsa052230.40004247
115MicroRNAs in cancer_Homo sapiens_hsa052060.39898392
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38640684
117Prion diseases_Homo sapiens_hsa050200.38440281
118Chemical carcinogenesis_Homo sapiens_hsa052040.38336373
119Thyroid cancer_Homo sapiens_hsa052160.38100515
120TNF signaling pathway_Homo sapiens_hsa046680.37879337
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37568933
122Fructose and mannose metabolism_Homo sapiens_hsa000510.36735039
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.35230595
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34779953
125Glutathione metabolism_Homo sapiens_hsa004800.34054826
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33512102
127Base excision repair_Homo sapiens_hsa034100.33282527
128Starch and sucrose metabolism_Homo sapiens_hsa005000.33194960
129Insulin secretion_Homo sapiens_hsa049110.32990065
130Galactose metabolism_Homo sapiens_hsa000520.29538960
131Apoptosis_Homo sapiens_hsa042100.29439578
132Endocytosis_Homo sapiens_hsa041440.28711733
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.24673097
134Nucleotide excision repair_Homo sapiens_hsa034200.22142750
135p53 signaling pathway_Homo sapiens_hsa041150.20401936
136Acute myeloid leukemia_Homo sapiens_hsa052210.19460332
137Insulin resistance_Homo sapiens_hsa049310.15747325
138Salivary secretion_Homo sapiens_hsa049700.15482615
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13022586
140Circadian rhythm_Homo sapiens_hsa047100.12191011
141RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11264679
142HIF-1 signaling pathway_Homo sapiens_hsa040660.10522386
143Salmonella infection_Homo sapiens_hsa051320.08666073
144Synaptic vesicle cycle_Homo sapiens_hsa047210.06142155
145Shigellosis_Homo sapiens_hsa051310.05088378
146Osteoclast differentiation_Homo sapiens_hsa043800.04662421

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