OTOS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Otospiralin is synthesized by nonsensory cells (fibrocytes) of the inner ear, and downregulation of otospiralin in guinea pigs leads to deafness (Lavigne-Rebillard et al., 2003 [PubMed 12687421]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.91297965
2viral transcription (GO:0019083)6.33989341
3translational termination (GO:0006415)6.01396382
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.72340656
5definitive hemopoiesis (GO:0060216)5.71769555
6ribosomal small subunit biogenesis (GO:0042274)5.47253044
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.36956010
8fucose catabolic process (GO:0019317)5.32652283
9L-fucose metabolic process (GO:0042354)5.32652283
10L-fucose catabolic process (GO:0042355)5.32652283
11translational elongation (GO:0006414)5.28491008
12cotranslational protein targeting to membrane (GO:0006613)5.27211385
13protein targeting to ER (GO:0045047)5.25132816
14regulation of cardioblast proliferation (GO:0003264)4.99211317
15regulation of secondary heart field cardioblast proliferation (GO:0003266)4.99211317
16auditory receptor cell differentiation (GO:0042491)4.99024784
17positive regulation of B cell differentiation (GO:0045579)4.98685974
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.98062332
19antigen processing and presentation via MHC class Ib (GO:0002475)4.97991701
20protein localization to endoplasmic reticulum (GO:0070972)4.92767989
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.72181052
22viral life cycle (GO:0019058)4.61208950
23lymphoid progenitor cell differentiation (GO:0002320)4.60199615
24cellular protein complex disassembly (GO:0043624)4.38575332
25lipopolysaccharide biosynthetic process (GO:0009103)4.36551545
26negative regulation of erythrocyte differentiation (GO:0045647)4.36392707
27cell aggregation (GO:0098743)4.26119057
28cartilage condensation (GO:0001502)4.26119057
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.18818772
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.18818772
31DNA deamination (GO:0045006)4.11467757
32maturation of SSU-rRNA (GO:0030490)4.05552252
33glycoprotein catabolic process (GO:0006516)4.02421168
34platelet dense granule organization (GO:0060155)3.97061776
35translational initiation (GO:0006413)3.89651919
36protein complex disassembly (GO:0043241)3.89002940
37response to interferon-beta (GO:0035456)3.82552324
38regulation of B cell differentiation (GO:0045577)3.81056456
39lipopolysaccharide metabolic process (GO:0008653)3.74428464
40pentose metabolic process (GO:0019321)3.67965903
41macromolecular complex disassembly (GO:0032984)3.59905539
42antigen processing and presentation of endogenous antigen (GO:0019883)3.51676840
43nuclear-transcribed mRNA catabolic process (GO:0000956)3.51449327
44diterpenoid biosynthetic process (GO:0016102)3.50964094
45protein targeting to membrane (GO:0006612)3.44762922
46pattern specification involved in kidney development (GO:0061004)3.36789284
47mRNA catabolic process (GO:0006402)3.34894006
48heparin metabolic process (GO:0030202)3.34292702
49heparin biosynthetic process (GO:0030210)3.34292702
50inner ear receptor cell differentiation (GO:0060113)3.33864996
51myeloid dendritic cell activation (GO:0001773)3.30069470
52leukotriene biosynthetic process (GO:0019370)3.29294982
53regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.27529237
54megakaryocyte development (GO:0035855)3.19595344
55deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.18250504
56positive regulation of granulocyte differentiation (GO:0030854)3.16538296
57regulation of heart morphogenesis (GO:2000826)3.16122687
58T cell homeostasis (GO:0043029)3.13795249
59secretory granule organization (GO:0033363)3.12452021
60T cell differentiation in thymus (GO:0033077)3.11296142
61positive regulation of receptor biosynthetic process (GO:0010870)3.09180068
62mast cell activation (GO:0045576)3.07092608
63galactose catabolic process (GO:0019388)3.04615370
64RNA catabolic process (GO:0006401)3.04107403
65regulation of T cell mediated cytotoxicity (GO:0001914)3.03488636
66negative regulation of phagocytosis (GO:0050765)3.02560347
67positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.99904544
68myeloid dendritic cell differentiation (GO:0043011)2.96564511
69positive regulation of T cell mediated cytotoxicity (GO:0001916)2.95038042
70positive regulation of gamma-delta T cell activation (GO:0046645)2.93976303
71negative regulation of glycoprotein biosynthetic process (GO:0010561)2.90916447
72response to interferon-alpha (GO:0035455)2.86002055
73positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84279084
74endosome to melanosome transport (GO:0035646)2.82900655
75endosome to pigment granule transport (GO:0043485)2.82900655
76regulation of gamma-delta T cell differentiation (GO:0045586)2.82664430
77regulation of erythrocyte differentiation (GO:0045646)2.81975017
78response to gravity (GO:0009629)2.80048163
79dendritic cell differentiation (GO:0097028)2.75921333
80Arp2/3 complex-mediated actin nucleation (GO:0034314)2.75179071
81negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.72776979
82dorsal/ventral axis specification (GO:0009950)2.71756821
83fucosylation (GO:0036065)2.70529144
84* sensory perception of sound (GO:0007605)2.69699622
85mast cell activation involved in immune response (GO:0002279)2.67113305
86mast cell degranulation (GO:0043303)2.67113305
87face development (GO:0060324)2.66413441
88germ cell migration (GO:0008354)2.66123831
89toxin transport (GO:1901998)2.64294269
90hair cell differentiation (GO:0035315)2.63070316
91fucose metabolic process (GO:0006004)2.62857371
92* sensory perception of mechanical stimulus (GO:0050954)2.62076706
93telomere maintenance via semi-conservative replication (GO:0032201)2.59602081
94generation of neurons (GO:0048699)2.59583844
95regulation of extracellular matrix disassembly (GO:0010715)2.59165454
96regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58889959
97type B pancreatic cell development (GO:0003323)2.57885708
98type B pancreatic cell proliferation (GO:0044342)2.56916259
99regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.56536964
100negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.56276368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.47239395
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.72035109
3SCL_19346495_ChIP-Seq_HPC-7_Human4.43588495
4E2F7_22180533_ChIP-Seq_HELA_Human4.40807155
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41496561
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.08051221
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.03606705
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.86467071
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.78831594
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.76890419
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76718607
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.76276327
13VDR_21846776_ChIP-Seq_THP-1_Human2.75079497
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.72352487
15TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.71806987
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.66692250
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.62492595
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55457704
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.43982247
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35971301
21MYC_22102868_ChIP-Seq_BL_Human2.33751255
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.29652536
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.28134542
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.27965876
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.27089157
26TRIM28_21343339_ChIP-Seq_HEK293_Human2.09329771
27VDR_24763502_ChIP-Seq_THP-1_Human2.01175912
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.98456393
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97187017
30ERG_20887958_ChIP-Seq_HPC-7_Mouse1.94981433
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92842405
32SPI1_23547873_ChIP-Seq_NB4_Human1.92479466
33MYB_26560356_Chip-Seq_TH2_Human1.86342378
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80445274
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76379075
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75062924
37GATA1_22025678_ChIP-Seq_K562_Human1.73714986
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.71906073
39IGF1R_20145208_ChIP-Seq_DFB_Human1.70389601
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.69959141
41* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69769541
42TCF7_22412390_ChIP-Seq_EML_Mouse1.69732607
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65219260
44RUNX_20019798_ChIP-Seq_JUKART_Human1.59875825
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58652399
46* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.56549857
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56472664
48* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51931675
49MAF_26560356_Chip-Seq_TH1_Human1.50024267
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.45102439
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.43327227
52* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40976596
53UTX_26944678_Chip-Seq_JUKART_Human1.40058117
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.37718282
55MYB_26560356_Chip-Seq_TH1_Human1.35428015
56* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33190490
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31567959
58XRN2_22483619_ChIP-Seq_HELA_Human1.31427400
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30317987
60* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29656339
61GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.28919407
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26668920
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23338898
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21425165
65MYC_18940864_ChIP-ChIP_HL60_Human1.21057193
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.19748523
67* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19240259
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11960566
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.11424798
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09317801
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.04218808
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04072503
73TTF2_22483619_ChIP-Seq_HELA_Human1.03663039
74GATA3_27048872_Chip-Seq_THYMUS_Human1.00999609
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00247859
76ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98607189
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97481242
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97463266
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97344466
80VDR_23849224_ChIP-Seq_CD4+_Human0.97141794
81ELK1_19687146_ChIP-ChIP_HELA_Human0.95060268
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94267979
83CIITA_25753668_ChIP-Seq_RAJI_Human0.92979868
84ELK3_25401928_ChIP-Seq_HUVEC_Human0.92938810
85MAF_26560356_Chip-Seq_TH2_Human0.88930674
86E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88040087
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88008260
88SRF_21415370_ChIP-Seq_HL-1_Mouse0.86073386
89SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.83988513
90GATA2_21666600_ChIP-Seq_HMVEC_Human0.83957130
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83692202
92RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82113054
93* PU_27001747_Chip-Seq_BMDM_Mouse0.82102542
94DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81725966
95FOXP3_21729870_ChIP-Seq_TREG_Human0.79891681
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.79705250
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77341389
98SPI1_23127762_ChIP-Seq_K562_Human0.76144787
99GATA3_26560356_Chip-Seq_TH2_Human0.75740846
100ELF5_23300383_ChIP-Seq_T47D_Human0.73392694

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003879_abnormal_hair_cell4.79720648
2MP0002396_abnormal_hematopoietic_system4.03218502
3* MP0001963_abnormal_hearing_physiology3.14781678
4MP0000685_abnormal_immune_system3.06785520
5* MP0000026_abnormal_inner_ear2.94865288
6MP0001835_abnormal_antigen_presentation2.85348505
7MP0001485_abnormal_pinna_reflex2.76921116
8MP0004808_abnormal_hematopoietic_stem2.66953978
9MP0005671_abnormal_response_to2.58743976
10MP0003763_abnormal_thymus_physiology2.52288909
11MP0000465_gastrointestinal_hemorrhage2.41416581
12MP0005174_abnormal_tail_pigmentation2.34957856
13MP0001545_abnormal_hematopoietic_system2.29730066
14MP0005397_hematopoietic_system_phenotyp2.29730066
15MP0001853_heart_inflammation2.13930628
16MP0005464_abnormal_platelet_physiology2.08545486
17MP0002933_joint_inflammation1.96059099
18MP0009785_altered_susceptibility_to1.92032857
19MP0002166_altered_tumor_susceptibility1.91822666
20MP0005248_abnormal_Harderian_gland1.87330502
21MP0005075_abnormal_melanosome_morpholog1.85636541
22MP0000372_irregular_coat_pigmentation1.80796341
23MP0009379_abnormal_foot_pigmentation1.80735030
24MP0002420_abnormal_adaptive_immunity1.77265788
25MP0001800_abnormal_humoral_immune1.76484860
26MP0002398_abnormal_bone_marrow1.76447883
27MP0000490_abnormal_crypts_of1.75042767
28MP0002938_white_spotting1.75037186
29MP0004885_abnormal_endolymph1.73311429
30MP0001819_abnormal_immune_cell1.72989141
31MP0005025_abnormal_response_to1.72191415
32MP0002095_abnormal_skin_pigmentation1.69978843
33MP0002452_abnormal_antigen_presenting1.65944454
34MP0005000_abnormal_immune_tolerance1.63624304
35MP0004134_abnormal_chest_morphology1.59962357
36MP0010155_abnormal_intestine_physiology1.59937818
37MP0003724_increased_susceptibility_to1.55380127
38MP0000716_abnormal_immune_system1.54935704
39MP0009278_abnormal_bone_marrow1.51713874
40MP0002419_abnormal_innate_immunity1.51685444
41MP0008007_abnormal_cellular_replicative1.51132081
42MP0002723_abnormal_immune_serum1.50814182
43MP0001533_abnormal_skeleton_physiology1.49193224
44MP0005377_hearing/vestibular/ear_phenot1.47769173
45MP0003878_abnormal_ear_physiology1.47769173
46MP0000689_abnormal_spleen_morphology1.46954806
47MP0002006_tumorigenesis1.45452374
48MP0003866_abnormal_defecation1.43630053
49MP0002722_abnormal_immune_system1.42200056
50MP0002429_abnormal_blood_cell1.39547088
51MP0003941_abnormal_skin_development1.37321817
52MP0002148_abnormal_hypersensitivity_rea1.36076145
53MP0003938_abnormal_ear_development1.33235721
54MP0000703_abnormal_thymus_morphology1.31485070
55MP0002102_abnormal_ear_morphology1.27214689
56MP0003436_decreased_susceptibility_to1.27202923
57MP0001873_stomach_inflammation1.20094182
58MP0006054_spinal_hemorrhage1.19609652
59MP0001986_abnormal_taste_sensitivity1.18661936
60MP0000383_abnormal_hair_follicle1.17410970
61MP0003942_abnormal_urinary_system1.15910059
62MP0005390_skeleton_phenotype1.09048184
63MP0003638_abnormal_response/metabolism_1.08846123
64MP0009333_abnormal_splenocyte_physiolog1.06439167
65MP0002877_abnormal_melanocyte_morpholog1.06054122
66MP0000681_abnormal_thyroid_gland1.02850679
67MP0003656_abnormal_erythrocyte_physiolo1.01480393
68MP0002405_respiratory_system_inflammati0.98262804
69MP0002233_abnormal_nose_morphology0.97179955
70MP0002249_abnormal_larynx_morphology0.94782048
71MP0000858_altered_metastatic_potential0.93152122
72MP0002254_reproductive_system_inflammat0.92023638
73MP0001845_abnormal_inflammatory_respons0.88985859
74MP0002019_abnormal_tumor_incidence0.87990862
75MP0003828_pulmonary_edema0.84017607
76MP0004147_increased_porphyrin_level0.83611202
77MP0010678_abnormal_skin_adnexa0.82867701
78MP0001790_abnormal_immune_system0.82721407
79MP0005387_immune_system_phenotype0.82721407
80MP0002277_abnormal_respiratory_mucosa0.81715292
81MP0003567_abnormal_fetal_cardiomyocyte0.80170443
82MP0005508_abnormal_skeleton_morphology0.79983135
83MP0000049_abnormal_middle_ear0.79406204
84MP0000566_synostosis0.76554140
85MP0003011_delayed_dark_adaptation0.74145789
86MP0002113_abnormal_skeleton_development0.72426277
87MP0004957_abnormal_blastocyst_morpholog0.72042800
88MP0000534_abnormal_ureter_morphology0.71149891
89MP0002115_abnormal_skeleton_extremities0.70881090
90MP0000163_abnormal_cartilage_morphology0.68114189
91MP0005367_renal/urinary_system_phenotyp0.67344712
92MP0000516_abnormal_urinary_system0.67344712
93MP0002089_abnormal_postnatal_growth/wei0.66651701
94MP0002098_abnormal_vibrissa_morphology0.65018583
95MP0002282_abnormal_trachea_morphology0.63907520
96MP0010094_abnormal_chromosome_stability0.63050922
97MP0001293_anophthalmia0.62891555
98MP0003693_abnormal_embryo_hatching0.62395815
99MP0003448_altered_tumor_morphology0.61837422
100MP0004264_abnormal_extraembryonic_tissu0.61228737

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)6.37590737
2Vitreoretinal degeneration (HP:0000655)6.25960346
3Severe Myopia (HP:0011003)5.70684611
4Mild short stature (HP:0003502)5.15363429
5Aplastic anemia (HP:0001915)4.74488003
6Thrombocytosis (HP:0001894)4.51965315
7Enlarged epiphyses (HP:0010580)4.20059653
8IgM deficiency (HP:0002850)4.07607580
9Abnormality of cells of the erythroid lineage (HP:0012130)4.04507364
10Genu varum (HP:0002970)3.96361711
11Delayed epiphyseal ossification (HP:0002663)3.85892500
12Abnormal number of erythroid precursors (HP:0012131)3.82229085
13Lip pit (HP:0100267)3.61394347
14Abnormality of the vitreous humor (HP:0004327)3.59785436
15Morphological abnormality of the inner ear (HP:0011390)3.42654119
16Metaphyseal dysplasia (HP:0100255)3.40929046
17Flattened epiphyses (HP:0003071)3.39249341
18Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.26362253
19Hypoplastic ischia (HP:0003175)3.24946166
20Small epiphyses (HP:0010585)3.23884657
21Reticulocytopenia (HP:0001896)3.22320134
22Chronic otitis media (HP:0000389)3.21804377
23Elevated erythrocyte sedimentation rate (HP:0003565)3.16185345
24Osteoarthritis (HP:0002758)3.14987076
25Colon cancer (HP:0003003)2.94100664
26Recurrent bacterial skin infections (HP:0005406)2.77983149
27Oral leukoplakia (HP:0002745)2.64887347
28Abnormality of the ischium (HP:0003174)2.62256000
29Microcytic anemia (HP:0001935)2.54268934
30Morphological abnormality of the middle ear (HP:0008609)2.54109882
31Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.50617894
32Absent epiphyses (HP:0010577)2.50617894
33Petechiae (HP:0000967)2.50495370
34Glossoptosis (HP:0000162)2.50177507
35Mixed hearing impairment (HP:0000410)2.49336306
36Macrocytic anemia (HP:0001972)2.49246183
37Inflammation of the large intestine (HP:0002037)2.46223521
38Gastrointestinal inflammation (HP:0004386)2.43184876
39Acute myeloid leukemia (HP:0004808)2.39114910
40Pallor (HP:0000980)2.38738883
41Recurrent skin infections (HP:0001581)2.34672256
42Recurrent bronchitis (HP:0002837)2.31309174
43Panhypogammaglobulinemia (HP:0003139)2.30964738
44Platyspondyly (HP:0000926)2.30722532
45Recurrent pneumonia (HP:0006532)2.30674142
46Arthralgia (HP:0002829)2.30618045
47Reduced antithrombin III activity (HP:0001976)2.29951205
48Abnormality of T cell physiology (HP:0011840)2.28965837
49Prolonged bleeding time (HP:0003010)2.27875219
50Thyroid-stimulating hormone excess (HP:0002925)2.23387428
51Beaking of vertebral bodies (HP:0004568)2.21886109
52Microretrognathia (HP:0000308)2.21399551
53Abnormality of the pubic bones (HP:0003172)2.20141246
54Hypothermia (HP:0002045)2.19923528
55Acute lymphatic leukemia (HP:0006721)2.19239209
56Vertebral clefting (HP:0008428)2.18805371
57Recurrent abscess formation (HP:0002722)2.17054884
58Retinopathy (HP:0000488)2.14265626
59Flared metaphyses (HP:0003015)2.13295349
60IgG deficiency (HP:0004315)2.11756572
61Cervical subluxation (HP:0003308)2.09298949
62Micromelia (HP:0002983)2.08976184
63Abnormal platelet function (HP:0011869)2.08748056
64Impaired platelet aggregation (HP:0003540)2.08748056
65Spondylolisthesis (HP:0003302)2.08497726
66Muscle fiber atrophy (HP:0100295)2.06032411
67Patchy hypopigmentation of hair (HP:0011365)2.04033339
68Generalized aminoaciduria (HP:0002909)2.02422462
69Epiphyseal dysplasia (HP:0002656)10.5959717
70Epistaxis (HP:0000421)1.99385978
71Colitis (HP:0002583)1.97873955
72Myositis (HP:0100614)1.97861398
73Type 2 muscle fiber atrophy (HP:0003554)1.96990231
74Gastrointestinal stroma tumor (HP:0100723)1.95674753
75Congenital, generalized hypertrichosis (HP:0004540)1.93843644
76Abnormality of the lumbar spine (HP:0100712)1.93816169
77Nonprogressive disorder (HP:0003680)1.92562415
78Thin bony cortex (HP:0002753)1.91771949
79Abnormality of the vertebral endplates (HP:0005106)1.91768776
80Recurrent lower respiratory tract infections (HP:0002783)1.87780867
81Exostoses (HP:0100777)1.83344456
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81885770
83Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81885770
84Spontaneous hematomas (HP:0007420)1.79922099
85Cellulitis (HP:0100658)1.79196207
86Annular pancreas (HP:0001734)1.76970633
87Abnormality of T cells (HP:0002843)1.76888388
88Hematochezia (HP:0002573)1.76555766
89Abnormal delayed hypersensitivity skin test (HP:0002963)1.75083958
90Bell-shaped thorax (HP:0001591)1.74470932
91Hypochromic anemia (HP:0001931)1.69208885
92Sprengel anomaly (HP:0000912)1.69148800
93Encephalitis (HP:0002383)1.69060569
94B lymphocytopenia (HP:0010976)1.68938061
95Abnormality of B cell number (HP:0010975)1.68938061
96Arterial tortuosity (HP:0005116)1.68569895
97Protrusio acetabuli (HP:0003179)1.68129750
98Agammaglobulinemia (HP:0004432)1.65400947
99Meningitis (HP:0001287)1.65048210
100Spinal cord lesions (HP:0100561)1.65036790

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.28289776
2CDK192.88316921
3FLT32.87693473
4BTK2.76413720
5EEF2K2.56773202
6TGFBR22.54369056
7KIT2.49482250
8PIM22.49470306
9MAP4K12.34490614
10TEC2.28273378
11TRPM72.19735263
12STK162.13072398
13PKN22.12677660
14MAP3K122.11739198
15TNIK1.98718953
16TGFBR11.87692333
17NME21.78856418
18CSF1R1.73062905
19MUSK1.73027095
20MAP2K31.64944570
21ACVR1B1.63573961
22EIF2AK31.60612182
23MAPKAPK31.49716987
24PAK41.42944579
25RPS6KB21.41027881
26LRRK21.35791560
27JAK31.30156806
28EIF2AK11.27164664
29MAP3K61.27049145
30MKNK11.21408561
31TESK21.17091455
32SYK1.17020710
33SCYL21.16635686
34EPHA31.16053056
35WEE11.13054624
36DAPK11.10073088
37FES1.07800955
38PASK1.05939408
39ITK1.00436027
40MAPKAPK50.99793544
41NLK0.97866927
42MATK0.95160805
43CDK60.90745959
44RIPK40.88549215
45IRAK40.87952420
46ILK0.85387244
47TBK10.84338286
48IKBKB0.84061571
49LYN0.82704078
50RAF10.82588567
51VRK10.81173168
52MKNK20.81088052
53GRK70.80585704
54EPHB10.80383544
55TXK0.80142094
56DYRK1B0.78538211
57ERBB30.77881776
58PTK60.77375594
59STK100.76481634
60BCKDK0.76234677
61MYLK0.75134560
62ZAP700.74896566
63CLK10.74753234
64CAMKK20.72920175
65BUB10.72591617
66MAP2K60.70266167
67MAPK40.70171911
68BLK0.70037850
69BMPR20.69717000
70HIPK20.69345356
71MAP3K30.67963934
72GRK60.67175860
73EIF2AK20.66331510
74KDR0.65224354
75TRIB30.65077930
76PAK20.64825327
77LCK0.64769634
78MOS0.64599689
79JAK20.59809180
80IKBKE0.58169648
81YES10.56749112
82PRKG20.55025977
83ADRBK20.53721690
84DYRK30.51617913
85PIM10.47100104
86PDK10.46834767
87RPS6KC10.45370065
88RPS6KL10.45370065
89HCK0.44978404
90CDC70.44513531
91BRSK20.43588539
92RPS6KA60.42755664
93CSNK1G10.41395689
94TYK20.39415432
95TAOK20.38615847
96CDK80.37814251
97BRSK10.36692021
98CSNK1G30.34059623
99MAP2K20.33339683
100ABL10.31847060

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.41853467
2DNA replication_Homo sapiens_hsa030303.85559515
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.36622133
4Primary immunodeficiency_Homo sapiens_hsa053402.73926030
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.58401567
6Mismatch repair_Homo sapiens_hsa034302.06731335
7Base excision repair_Homo sapiens_hsa034101.97431788
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95456529
9Protein digestion and absorption_Homo sapiens_hsa049741.88601585
10Leishmaniasis_Homo sapiens_hsa051401.86217335
11Antigen processing and presentation_Homo sapiens_hsa046121.77938809
12B cell receptor signaling pathway_Homo sapiens_hsa046621.71324578
13Spliceosome_Homo sapiens_hsa030401.67997442
14ECM-receptor interaction_Homo sapiens_hsa045121.67216802
15Transcriptional misregulation in cancer_Homo sapiens_hsa052021.64406868
16Histidine metabolism_Homo sapiens_hsa003401.61740033
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59344959
18Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.57823053
19Homologous recombination_Homo sapiens_hsa034401.57373842
20N-Glycan biosynthesis_Homo sapiens_hsa005101.55623042
21Protein export_Homo sapiens_hsa030601.48196520
22Pyrimidine metabolism_Homo sapiens_hsa002401.46192528
23Thyroid cancer_Homo sapiens_hsa052161.46100914
24Caffeine metabolism_Homo sapiens_hsa002321.37237481
25Shigellosis_Homo sapiens_hsa051311.28990002
26Chronic myeloid leukemia_Homo sapiens_hsa052201.28049989
27RNA degradation_Homo sapiens_hsa030181.26942918
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22684005
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21252648
30Acute myeloid leukemia_Homo sapiens_hsa052211.20802698
31Nucleotide excision repair_Homo sapiens_hsa034201.15974946
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.15652303
33Osteoclast differentiation_Homo sapiens_hsa043801.15266072
34Proteasome_Homo sapiens_hsa030501.12194683
35Other glycan degradation_Homo sapiens_hsa005111.07845107
36HTLV-I infection_Homo sapiens_hsa051661.07459712
37Non-homologous end-joining_Homo sapiens_hsa034501.06829946
38Cell cycle_Homo sapiens_hsa041101.06817857
39Herpes simplex infection_Homo sapiens_hsa051681.06399923
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06131621
41Hematopoietic cell lineage_Homo sapiens_hsa046401.05776820
42Wnt signaling pathway_Homo sapiens_hsa043101.02101305
43RNA polymerase_Homo sapiens_hsa030201.00278790
44Colorectal cancer_Homo sapiens_hsa052101.00194994
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.98990774
46Basal cell carcinoma_Homo sapiens_hsa052170.98841025
47Platelet activation_Homo sapiens_hsa046110.98480078
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.95459828
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90774457
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89346822
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87745448
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87606305
53Measles_Homo sapiens_hsa051620.85973563
54Malaria_Homo sapiens_hsa051440.84580491
55Toxoplasmosis_Homo sapiens_hsa051450.82303614
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.80440135
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79977745
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78050515
59Focal adhesion_Homo sapiens_hsa045100.76834132
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75884988
61Asthma_Homo sapiens_hsa053100.75841453
62Hepatitis B_Homo sapiens_hsa051610.74010620
63Pertussis_Homo sapiens_hsa051330.72678401
64Legionellosis_Homo sapiens_hsa051340.71377653
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71339589
66p53 signaling pathway_Homo sapiens_hsa041150.71119715
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70729759
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70261904
69beta-Alanine metabolism_Homo sapiens_hsa004100.69005554
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67669977
71Purine metabolism_Homo sapiens_hsa002300.62986850
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61912965
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58738289
74Small cell lung cancer_Homo sapiens_hsa052220.58305032
75Pathways in cancer_Homo sapiens_hsa052000.57116745
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56296859
77TGF-beta signaling pathway_Homo sapiens_hsa043500.55560487
78Apoptosis_Homo sapiens_hsa042100.54065592
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.53880815
80Systemic lupus erythematosus_Homo sapiens_hsa053220.52513038
81Pancreatic cancer_Homo sapiens_hsa052120.50154082
82T cell receptor signaling pathway_Homo sapiens_hsa046600.48072932
83Hippo signaling pathway_Homo sapiens_hsa043900.44793781
84Proteoglycans in cancer_Homo sapiens_hsa052050.44528804
85Non-small cell lung cancer_Homo sapiens_hsa052230.44410637
86TNF signaling pathway_Homo sapiens_hsa046680.44399417
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.43931479
88Notch signaling pathway_Homo sapiens_hsa043300.43621762
89Pentose phosphate pathway_Homo sapiens_hsa000300.40694387
90Galactose metabolism_Homo sapiens_hsa000520.38424287
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37617904
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37492657
93Hepatitis C_Homo sapiens_hsa051600.37458582
94Viral myocarditis_Homo sapiens_hsa054160.36045045
95RNA transport_Homo sapiens_hsa030130.34919999
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34861768
97Phenylalanine metabolism_Homo sapiens_hsa003600.34183914
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32712842
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32682511
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29608947

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