OTP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription factors that play key roles in the specification of cell fates. This protein may function during brain development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)9.53499029
2nucleobase catabolic process (GO:0046113)7.53776773
3drinking behavior (GO:0042756)5.71251321
4regulation of feeding behavior (GO:0060259)5.62895297
5regulation of glutamate secretion (GO:0014048)5.53068039
6response to pheromone (GO:0019236)5.41318351
7negative regulation of amino acid transport (GO:0051956)5.34125769
8positive regulation of amino acid transport (GO:0051957)5.26216236
9neuron fate specification (GO:0048665)5.22281486
10female mating behavior (GO:0060180)5.11101942
11adult feeding behavior (GO:0008343)5.06210226
12aggressive behavior (GO:0002118)4.87712629
13adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.84252446
14regulation of female receptivity (GO:0045924)4.76943189
15mating behavior (GO:0007617)4.68035118
16respiratory system process (GO:0003016)4.65129759
17positive regulation of mitochondrial fission (GO:0090141)4.62771315
18establishment of mitochondrion localization (GO:0051654)4.51940463
19opioid receptor signaling pathway (GO:0038003)4.46866331
20daunorubicin metabolic process (GO:0044597)4.44271125
21polyketide metabolic process (GO:0030638)4.44271125
22doxorubicin metabolic process (GO:0044598)4.44271125
23cell migration in hindbrain (GO:0021535)4.36959861
24mitochondrion transport along microtubule (GO:0047497)4.21187928
25establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.21187928
26positive regulation of prostaglandin secretion (GO:0032308)3.98625258
27establishment of nucleus localization (GO:0040023)3.96810244
28regulation of transmission of nerve impulse (GO:0051969)3.93669335
29positive regulation of organic acid transport (GO:0032892)3.92927958
30synapse assembly (GO:0007416)3.92276559
31central nervous system projection neuron axonogenesis (GO:0021952)3.89678611
32positive regulation of uterine smooth muscle contraction (GO:0070474)3.82027625
33neuronal ion channel clustering (GO:0045161)3.80305901
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.78877449
35positive regulation of amine transport (GO:0051954)3.78198720
36eosinophil chemotaxis (GO:0048245)3.77921957
37regulation of amino acid transport (GO:0051955)3.76522073
38regulation of chromatin binding (GO:0035561)3.75161533
39response to dietary excess (GO:0002021)3.74653985
40spinal cord development (GO:0021510)3.72842120
41positive regulation of synaptic transmission, GABAergic (GO:0032230)3.71840078
42neuron cell-cell adhesion (GO:0007158)3.68380972
43response to parathyroid hormone (GO:0071107)3.68239675
44synaptic vesicle maturation (GO:0016188)3.66873701
45cerebellar Purkinje cell layer development (GO:0021680)3.66304036
46positive regulation of synapse assembly (GO:0051965)3.66129164
47regulation of uterine smooth muscle contraction (GO:0070472)3.65362823
48axonal fasciculation (GO:0007413)3.58925371
49negative chemotaxis (GO:0050919)3.58904378
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.58394703
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.55654990
52eating behavior (GO:0042755)3.55437607
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.53580201
54neuromuscular process controlling posture (GO:0050884)3.50875007
55neuron recognition (GO:0008038)3.50708599
56calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.48680863
57positive regulation of protein homooligomerization (GO:0032464)3.48309788
58inner ear receptor stereocilium organization (GO:0060122)3.47452555
59sequestering of actin monomers (GO:0042989)3.46591034
60regulation of prostaglandin secretion (GO:0032306)3.45768538
61energy homeostasis (GO:0097009)3.45304458
62axon extension involved in axon guidance (GO:0048846)3.43867123
63neuron projection extension involved in neuron projection guidance (GO:1902284)3.43867123
64neurofilament cytoskeleton organization (GO:0060052)3.41558180
65dendritic spine morphogenesis (GO:0060997)3.41397430
66regulation of NFAT protein import into nucleus (GO:0051532)3.41025149
67ionotropic glutamate receptor signaling pathway (GO:0035235)3.39719882
68retinal ganglion cell axon guidance (GO:0031290)3.39305269
69negative regulation of amine transport (GO:0051953)3.38873403
70regulation of glutamate receptor signaling pathway (GO:1900449)3.38552875
71auditory receptor cell stereocilium organization (GO:0060088)3.38191962
72positive regulation of icosanoid secretion (GO:0032305)3.38153272
73regulation of synapse structural plasticity (GO:0051823)3.37749584
74maternal behavior (GO:0042711)3.37627449
75response to histamine (GO:0034776)3.33697140
76vocalization behavior (GO:0071625)3.31214787
77kidney mesenchyme development (GO:0072074)3.29527933
78eosinophil migration (GO:0072677)3.29096574
79regulation of protein kinase A signaling (GO:0010738)3.27099167
80dendrite morphogenesis (GO:0048813)3.26072573
81locomotory exploration behavior (GO:0035641)3.25581298
82presynaptic membrane assembly (GO:0097105)3.25053173
83regulation of synaptic vesicle exocytosis (GO:2000300)3.24126685
84primary amino compound metabolic process (GO:1901160)3.23403406
85serotonin metabolic process (GO:0042428)3.23003988
86protein localization to synapse (GO:0035418)3.22600207
87axon extension (GO:0048675)3.19165656
88positive regulation of action potential (GO:0045760)3.18986993
89central nervous system neuron axonogenesis (GO:0021955)3.18128590
90cilium movement (GO:0003341)3.17962457
91mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.17452062
92ovulation cycle (GO:0042698)3.16222645
93synapse organization (GO:0050808)3.15984985
94neuronal stem cell maintenance (GO:0097150)3.14867465
95regulation of axon guidance (GO:1902667)3.12684391
96postsynaptic membrane organization (GO:0001941)3.10890179
97regulation of axon extension involved in axon guidance (GO:0048841)3.10112590
98grooming behavior (GO:0007625)3.08719730
99behavioral response to nicotine (GO:0035095)3.08048855
100negative regulation of axon guidance (GO:1902668)3.07935205
101transmission of nerve impulse (GO:0019226)3.07877879
102positive regulation of catecholamine secretion (GO:0033605)3.07724041
103presynaptic membrane organization (GO:0097090)3.07223676
104glutamate receptor signaling pathway (GO:0007215)3.05382540
105peroxisome fission (GO:0016559)3.04110126
106startle response (GO:0001964)3.03804647
107regulation of mitochondrial fission (GO:0090140)3.03476058
108negative regulation of axon extension involved in axon guidance (GO:0048843)3.02593495
109sleep (GO:0030431)3.01577996
110pattern specification involved in kidney development (GO:0061004)3.00802792
111innervation (GO:0060384)3.00567008
112negative regulation of cytosolic calcium ion concentration (GO:0051481)2.99645673
113regulation of short-term neuronal synaptic plasticity (GO:0048172)2.98053101
114protein localization to cilium (GO:0061512)2.96926201
115axon ensheathment in central nervous system (GO:0032291)2.96534012
116central nervous system myelination (GO:0022010)2.96534012
117mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.96475774
118neuromuscular synaptic transmission (GO:0007274)2.96328651
119axonemal dynein complex assembly (GO:0070286)2.95579078
120proline transport (GO:0015824)2.95491344
121regulation of synapse assembly (GO:0051963)2.95343747
122negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94865700
123positive regulation of fatty acid transport (GO:2000193)2.92961750
124parental behavior (GO:0060746)2.92696322
125feeding behavior (GO:0007631)2.90913546
126dendrite development (GO:0016358)2.90772055
127protein insertion into membrane (GO:0051205)2.89857268
128regulation of microtubule-based movement (GO:0060632)2.89244492
129negative regulation of neurotransmitter secretion (GO:0046929)2.88732856
130synaptic transmission, glutamatergic (GO:0035249)2.88246682
131regulation of synaptic vesicle transport (GO:1902803)2.86747654
132negative regulation of axon extension (GO:0030517)2.86245677
133regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.83612278
134detection of calcium ion (GO:0005513)2.82607928
135positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.82312513
136multicellular organismal reproductive behavior (GO:0033057)2.82255612
137negative regulation of axonogenesis (GO:0050771)2.81966679
138hippocampus development (GO:0021766)2.81564559
139regulation of beta-amyloid formation (GO:1902003)2.80379584
140motile cilium assembly (GO:0044458)2.78702783
141hyperosmotic salinity response (GO:0042538)2.77521205
142regulation of chemokine-mediated signaling pathway (GO:0070099)2.76763399
143establishment of melanosome localization (GO:0032401)2.76729008
144synaptic vesicle exocytosis (GO:0016079)2.76430654
145nonmotile primary cilium assembly (GO:0035058)2.76355764
146establishment of protein localization to mitochondrial membrane (GO:0090151)2.76227858
147neuropeptide signaling pathway (GO:0007218)2.76098256
148adult locomotory behavior (GO:0008344)2.75348926
149microtubule severing (GO:0051013)2.74728520
150response to prostaglandin E (GO:0034695)2.74706175
151cilium or flagellum-dependent cell motility (GO:0001539)2.73824316
152regulation of synaptic transmission, GABAergic (GO:0032228)2.73314049
153positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.72475950
154neuron remodeling (GO:0016322)2.72436038
155cerebellum development (GO:0021549)2.71862459
156positive regulation of potassium ion transmembrane transport (GO:1901381)2.71614094
157negative regulation of neurotransmitter transport (GO:0051589)2.70738897
158aminoglycoside antibiotic metabolic process (GO:0030647)2.69148012
159neuronal action potential propagation (GO:0019227)2.67810030
160regulation of norepinephrine secretion (GO:0014061)2.66798129
161neuron migration (GO:0001764)2.66185923
162multi-organism reproductive behavior (GO:0044705)2.65336397
163metanephric mesenchyme development (GO:0072075)2.65284799
164positive regulation of cellular amide metabolic process (GO:0034250)2.65166585
165homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.64780239
166establishment of pigment granule localization (GO:0051905)2.64389148
167negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.64180058
168glycosphingolipid biosynthetic process (GO:0006688)2.63150079
169spinal cord association neuron differentiation (GO:0021527)2.62605773
170pyrimidine dimer repair (GO:0006290)2.61782723
171cerebral cortex radially oriented cell migration (GO:0021799)2.61667581
172nervous system development (GO:0007399)2.61259398
173phagosome maturation (GO:0090382)2.60489854
174* forebrain neuron differentiation (GO:0021879)2.60391970
175righting reflex (GO:0060013)2.60054997
176adult walking behavior (GO:0007628)2.59303924
177positive regulation of digestive system process (GO:0060456)2.58447846
178neurotransmitter-gated ion channel clustering (GO:0072578)2.56520023
179activation of protein kinase A activity (GO:0034199)2.56030054
180epithelial cilium movement (GO:0003351)2.55743223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.03266447
2GBX2_23144817_ChIP-Seq_PC3_Human3.63188644
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.15757103
4TAF15_26573619_Chip-Seq_HEK293_Human3.15078643
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64442014
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60836253
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.57656824
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.52992987
9* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.48373006
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.45032791
11* EED_16625203_ChIP-ChIP_MESCs_Mouse2.44906460
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41508089
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39790959
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36436578
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34544405
16* EZH2_27304074_Chip-Seq_ESCs_Mouse2.32548553
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27347101
18* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22052452
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20823542
20IGF1R_20145208_ChIP-Seq_DFB_Human2.12644290
21* REST_21632747_ChIP-Seq_MESCs_Mouse2.12028316
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11145167
23* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07424308
24P300_19829295_ChIP-Seq_ESCs_Human2.05252376
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05136832
26* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02913128
27* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02913128
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00294310
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96062492
30* CBX2_27304074_Chip-Seq_ESCs_Mouse1.95693311
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92055657
32* RNF2_27304074_Chip-Seq_NSC_Mouse1.91810575
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.90503554
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.88876135
35* EZH2_27294783_Chip-Seq_ESCs_Mouse1.87625635
36* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82860563
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81114791
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80203746
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78876064
40AR_21572438_ChIP-Seq_LNCaP_Human1.76279770
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.73973901
42* RNF2_27304074_Chip-Seq_ESCs_Mouse1.73183636
43SMAD4_21799915_ChIP-Seq_A2780_Human1.72612898
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67798929
45* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61992652
46* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61934141
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59773317
48ER_23166858_ChIP-Seq_MCF-7_Human1.55585999
49* RING1B_27294783_Chip-Seq_ESCs_Mouse1.54312468
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54138924
51FUS_26573619_Chip-Seq_HEK293_Human1.51461487
52* TP53_20018659_ChIP-ChIP_R1E_Mouse1.49718951
53* REST_18959480_ChIP-ChIP_MESCs_Mouse1.49154351
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.49123028
55* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49041522
56OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.47983997
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.44604429
58AR_25329375_ChIP-Seq_VCAP_Human1.43544461
59* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43413570
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41635068
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.41273984
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41216172
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40254904
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.39459580
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.38968867
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35778940
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.31820417
68ZNF274_21170338_ChIP-Seq_K562_Hela1.30810026
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.30704272
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30396134
71P53_22387025_ChIP-Seq_ESCs_Mouse1.29823572
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29573573
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29524191
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.28773177
75DROSHA_22980978_ChIP-Seq_HELA_Human1.27150929
76RUNX2_22187159_ChIP-Seq_PCA_Human1.25709923
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24674255
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23984525
79JUN_21703547_ChIP-Seq_K562_Human1.23708840
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.23507976
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.22958360
82IRF1_19129219_ChIP-ChIP_H3396_Human1.22477739
83EWS_26573619_Chip-Seq_HEK293_Human1.22408755
84RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22322536
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.18917952
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16189553
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15834305
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15128062
89TCF4_23295773_ChIP-Seq_U87_Human1.14964118
90ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13915230
91RARB_27405468_Chip-Seq_BRAIN_Mouse1.13851585
92P300_18555785_Chip-Seq_ESCs_Mouse1.12099761
93VDR_22108803_ChIP-Seq_LS180_Human1.11471255
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11304575
95* RING1B_27294783_Chip-Seq_NPCs_Mouse1.11232207
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10558432
97RUNX1_27457419_Chip-Seq_LIVER_Mouse1.10463305
98KDM2B_26808549_Chip-Seq_REH_Human1.10446066
99SOX2_18555785_Chip-Seq_ESCs_Mouse1.09332073
100* STAT3_23295773_ChIP-Seq_U87_Human1.08862744
101NMYC_18555785_Chip-Seq_ESCs_Mouse1.08727951
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07168862
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07168862
104* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06804250
105WT1_19549856_ChIP-ChIP_CCG9911_Human1.05351318
106CTCF_18555785_Chip-Seq_ESCs_Mouse1.03062191
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02554931
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01761240
109KLF4_18555785_Chip-Seq_ESCs_Mouse1.01626265
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01403835
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00800745
112* SOX2_16153702_ChIP-ChIP_HESCs_Human1.00783630
113* TAL1_26923725_Chip-Seq_HPCs_Mouse0.99863432
114ZFX_18555785_Chip-Seq_ESCs_Mouse0.98443636
115* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98317618
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98150410
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97974736
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97477374
119P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96339272
120EGR1_19032775_ChIP-ChIP_M12_Human0.95869510
121* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.94763520
122AR_19668381_ChIP-Seq_PC3_Human0.91939610
123SALL1_21062744_ChIP-ChIP_HESCs_Human0.90618239
124ISL1_27105846_Chip-Seq_CPCs_Mouse0.89393011
125KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88833453
126* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88319319
127BCAT_22108803_ChIP-Seq_LS180_Human0.88194853
128TP63_19390658_ChIP-ChIP_HaCaT_Human0.86032453
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85114265
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82193311
131POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.80976422
132NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80936134
133* SOX9_26525672_Chip-Seq_HEART_Mouse0.80679670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting5.51650481
2MP0003880_abnormal_central_pattern4.81505361
3MP0006276_abnormal_autonomic_nervous4.49129222
4MP0005423_abnormal_somatic_nervous3.48934500
5* MP0005645_abnormal_hypothalamus_physiol3.40425238
6MP0003121_genomic_imprinting2.91182791
7MP0001440_abnormal_grooming_behavior2.79034934
8MP0003123_paternal_imprinting2.75964129
9MP0005646_abnormal_pituitary_gland2.73406466
10MP0002653_abnormal_ependyma_morphology2.70844462
11MP0003787_abnormal_imprinting2.67678116
12MP0001968_abnormal_touch/_nociception2.64316064
13MP0003635_abnormal_synaptic_transmissio2.45334607
14MP0001502_abnormal_circadian_rhythm2.39955617
15MP0004859_abnormal_synaptic_plasticity2.38562217
16MP0002736_abnormal_nociception_after2.37939799
17MP0009745_abnormal_behavioral_response2.35927225
18MP0002572_abnormal_emotion/affect_behav2.25572538
19MP0001986_abnormal_taste_sensitivity2.24760513
20MP0006292_abnormal_olfactory_placode2.23748767
21MP0002064_seizures2.18476056
22MP0001188_hyperpigmentation2.16740036
23MP0002876_abnormal_thyroid_physiology2.11362778
24MP0001501_abnormal_sleep_pattern2.10181560
25MP0009046_muscle_twitch2.06620794
26MP0004142_abnormal_muscle_tone2.02326150
27MP0002063_abnormal_learning/memory/cond1.96984149
28MP0005187_abnormal_penis_morphology1.95460060
29MP0002638_abnormal_pupillary_reflex1.94426063
30MP0001984_abnormal_olfaction1.91792053
31MP0002272_abnormal_nervous_system1.89460599
32MP0002735_abnormal_chemical_nociception1.88656529
33MP0001529_abnormal_vocalization1.87447374
34MP0001486_abnormal_startle_reflex1.86272349
35MP0005379_endocrine/exocrine_gland_phen1.81744636
36MP0000569_abnormal_digit_pigmentation1.73863503
37MP0002557_abnormal_social/conspecific_i1.72538115
38MP0002067_abnormal_sensory_capabilities1.70124845
39MP0003315_abnormal_perineum_morphology1.67514184
40MP0002163_abnormal_gland_morphology1.67291132
41MP0002734_abnormal_mechanical_nocicepti1.56629350
42MP0001970_abnormal_pain_threshold1.52581634
43MP0002733_abnormal_thermal_nociception1.45249887
44MP0000778_abnormal_nervous_system1.44497366
45MP0004742_abnormal_vestibular_system1.39338877
46MP0010386_abnormal_urinary_bladder1.37748428
47MP0000566_synostosis1.37172224
48MP0008789_abnormal_olfactory_epithelium1.36499181
49MP0004924_abnormal_behavior1.34646424
50MP0005386_behavior/neurological_phenoty1.34646424
51MP0002184_abnormal_innervation1.31335276
52MP0005394_taste/olfaction_phenotype1.30411401
53MP0005499_abnormal_olfactory_system1.30411401
54MP0002160_abnormal_reproductive_system1.30172294
55MP0003959_abnormal_lean_body1.24995997
56* MP0000631_abnormal_neuroendocrine_gland1.24883875
57MP0002102_abnormal_ear_morphology1.21015958
58MP0004270_analgesia1.17767958
59MP0009697_abnormal_copulation1.11687336
60MP0000751_myopathy1.10788676
61MP0002277_abnormal_respiratory_mucosa1.00213413
62MP0003136_yellow_coat_color0.98358896
63MP0005551_abnormal_eye_electrophysiolog0.98255357
64MP0000647_abnormal_sebaceous_gland0.96023440
65MP0006072_abnormal_retinal_apoptosis0.95857595
66MP0008004_abnormal_stomach_pH0.95390032
67MP0004885_abnormal_endolymph0.93838673
68MP0002066_abnormal_motor_capabilities/c0.92838365
69MP0003861_abnormal_nervous_system0.92679640
70MP0002069_abnormal_eating/drinking_beha0.92251175
71MP0001905_abnormal_dopamine_level0.90704117
72MP0008995_early_reproductive_senescence0.90630026
73MP0005171_absent_coat_pigmentation0.89236357
74MP0008877_abnormal_DNA_methylation0.88979706
75* MP0002882_abnormal_neuron_morphology0.85494646
76MP0005253_abnormal_eye_physiology0.84692888
77MP0002938_white_spotting0.83982647
78MP0001963_abnormal_hearing_physiology0.83365243
79MP0000534_abnormal_ureter_morphology0.80694397
80MP0000026_abnormal_inner_ear0.79430820
81MP0003878_abnormal_ear_physiology0.75857212
82MP0005377_hearing/vestibular/ear_phenot0.75857212
83MP0005535_abnormal_body_temperature0.74977260
84MP0003283_abnormal_digestive_organ0.74977173
85MP0003879_abnormal_hair_cell0.74519457
86MP0002909_abnormal_adrenal_gland0.73701975
87MP0003942_abnormal_urinary_system0.73409093
88MP0002751_abnormal_autonomic_nervous0.73398161
89MP0003183_abnormal_peptide_metabolism0.72758900
90MP0002928_abnormal_bile_duct0.72294207
91MP0005389_reproductive_system_phenotype0.72290363
92MP0000955_abnormal_spinal_cord0.71398464
93MP0005409_darkened_coat_color0.71269869
94MP0008872_abnormal_physiological_respon0.70389739
95MP0002332_abnormal_exercise_endurance0.70151758
96MP0002822_catalepsy0.69261253
97MP0001485_abnormal_pinna_reflex0.68904867
98MP0002752_abnormal_somatic_nervous0.68197342
99MP0005310_abnormal_salivary_gland0.68076239
100MP0004858_abnormal_nervous_system0.66760574
101MP0000681_abnormal_thyroid_gland0.66378262
102MP0001664_abnormal_digestion0.65220879
103MP0003646_muscle_fatigue0.64990125
104* MP0002152_abnormal_brain_morphology0.64794117
105MP0003948_abnormal_gas_homeostasis0.63647862
106MP0003690_abnormal_glial_cell0.63643252
107MP0003011_delayed_dark_adaptation0.63382515
108MP0009379_abnormal_foot_pigmentation0.62765087
109MP0003329_amyloid_beta_deposits0.61947483
110MP0001943_abnormal_respiration0.61858816
111MP0005195_abnormal_posterior_eye0.59953475
112MP0005448_abnormal_energy_balance0.58957183
113MP0003724_increased_susceptibility_to0.58423686
114MP0004811_abnormal_neuron_physiology0.58266185
115MP0002693_abnormal_pancreas_physiology0.57909287
116MP0003119_abnormal_digestive_system0.57727162
117MP0008260_abnormal_autophagy0.57247432
118MP0001346_abnormal_lacrimal_gland0.56851202
119MP0003698_abnormal_male_reproductive0.56737970
120MP0003941_abnormal_skin_development0.56592841
121MP0003634_abnormal_glial_cell0.55915898
122MP0002081_perinatal_lethality0.54853020
123MP0001299_abnormal_eye_distance/0.54529047
124MP0008770_decreased_survivor_rate0.53308230
125MP0004133_heterotaxia0.53034412
126MP0008569_lethality_at_weaning0.52436442
127MP0002229_neurodegeneration0.52326890
128MP0003633_abnormal_nervous_system0.52191875
129MP0003938_abnormal_ear_development0.52129553
130MP0000049_abnormal_middle_ear0.50903255
131MP0000015_abnormal_ear_pigmentation0.50788071
132MP0002210_abnormal_sex_determination0.48673558
133* MP0002082_postnatal_lethality0.47491100
134* MP0010770_preweaning_lethality0.47491100
135* MP0010769_abnormal_survival0.47446740
136* MP0010768_mortality/aging0.46629330
137MP0004085_abnormal_heartbeat0.45115377

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair whorl (HP:0010721)6.45482181
2Abnormal ciliary motility (HP:0012262)6.14478183
3Abnormal respiratory motile cilium morphology (HP:0005938)5.55001157
4Abnormal respiratory epithelium morphology (HP:0012253)5.55001157
5Focal motor seizures (HP:0011153)5.03210412
6Abnormal respiratory motile cilium physiology (HP:0012261)4.77250468
7Febrile seizures (HP:0002373)4.73494713
8Polyphagia (HP:0002591)4.68618365
9Atonic seizures (HP:0010819)4.68553436
10Absent/shortened dynein arms (HP:0200106)4.66372968
11Dynein arm defect of respiratory motile cilia (HP:0012255)4.66372968
12Cortical dysplasia (HP:0002539)4.34127081
13Failure to thrive in infancy (HP:0001531)4.22155701
14Oligomenorrhea (HP:0000876)4.05845283
15Abnormality of the labia minora (HP:0012880)3.98400495
16Rhinitis (HP:0012384)3.88008244
17Retinal dysplasia (HP:0007973)3.78623842
18Aplasia/Hypoplasia of the brainstem (HP:0007362)3.61847643
19Hypoplasia of the brainstem (HP:0002365)3.61847643
20Narrow nasal bridge (HP:0000446)3.49533642
21Lissencephaly (HP:0001339)3.31861802
22Megalencephaly (HP:0001355)3.29040485
23Abnormal eating behavior (HP:0100738)3.18738848
24Poor suck (HP:0002033)3.18567803
25Chronic sinusitis (HP:0011109)3.14678413
26Genetic anticipation (HP:0003743)3.13485773
27Medial flaring of the eyebrow (HP:0010747)3.08498829
28Focal seizures (HP:0007359)3.08269602
29Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.02297665
30Pachygyria (HP:0001302)2.95274490
31Sleep apnea (HP:0010535)2.95087912
32Gait imbalance (HP:0002141)2.94099105
33Epileptic encephalopathy (HP:0200134)2.91635236
34Absence seizures (HP:0002121)2.90468260
35Abnormality of the corticospinal tract (HP:0002492)2.90168269
36Abnormal number of erythroid precursors (HP:0012131)2.88451380
37Hyperphosphatemia (HP:0002905)2.86849006
38Menstrual irregularities (HP:0000858)2.84624221
39Hip dysplasia (HP:0001385)2.80298615
40Abnormality of calcium-phosphate metabolism (HP:0100530)2.78853968
41Nephrogenic diabetes insipidus (HP:0009806)2.78417353
42Congenital primary aphakia (HP:0007707)2.74597181
43Esotropia (HP:0000565)2.74502476
44Gonadotropin excess (HP:0000837)2.72094328
45Agitation (HP:0000713)2.71859087
46Molar tooth sign on MRI (HP:0002419)2.66771893
47Abnormality of midbrain morphology (HP:0002418)2.66771893
48Type II lissencephaly (HP:0007260)2.66269968
49Intestinal atresia (HP:0011100)2.64201514
50Dialeptic seizures (HP:0011146)2.63072876
51Nephronophthisis (HP:0000090)2.55264524
52Polymicrogyria (HP:0002126)2.52929663
53Parakeratosis (HP:0001036)2.52090964
54Hypoventilation (HP:0002791)2.51697111
55Drooling (HP:0002307)2.50610807
56Osteomalacia (HP:0002749)2.50033717
57Myokymia (HP:0002411)2.48919406
58Abnormality of cells of the erythroid lineage (HP:0012130)2.48655553
59Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.45842648
60Generalized tonic-clonic seizures (HP:0002069)2.44588102
61Wrist flexion contracture (HP:0001239)2.40671793
62Abnormality of the lower motor neuron (HP:0002366)2.39835658
63Pancreatic cysts (HP:0001737)2.38403949
64Elfin facies (HP:0004428)2.36875739
65Hypothermia (HP:0002045)2.34881456
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.34118450
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.34118450
68Acute necrotizing encephalopathy (HP:0006965)2.33969781
69Supernumerary spleens (HP:0009799)2.33910368
70Morphological abnormality of the pyramidal tract (HP:0002062)2.31225374
71Excessive salivation (HP:0003781)2.29534155
72Specific learning disability (HP:0001328)2.26789234
73Amyotrophic lateral sclerosis (HP:0007354)2.25463160
74Methylmalonic acidemia (HP:0002912)2.23883942
75Urinary urgency (HP:0000012)2.23217400
76True hermaphroditism (HP:0010459)2.23100618
77Insomnia (HP:0100785)2.20321154
78Pheochromocytoma (HP:0002666)2.20049159
79Homocystinuria (HP:0002156)2.19876003
80Abnormality of homocysteine metabolism (HP:0010919)2.19876003
81Pancreatic fibrosis (HP:0100732)2.18556047
82Growth hormone deficiency (HP:0000824)2.16478652
83Mitochondrial inheritance (HP:0001427)2.15427598
84Ulnar claw (HP:0001178)2.15202064
85Abnormal mitochondria in muscle tissue (HP:0008316)2.14688315
86Morphological abnormality of the middle ear (HP:0008609)2.10038596
87Truncal obesity (HP:0001956)2.09522419
88Renovascular hypertension (HP:0100817)2.08644267
89Broad foot (HP:0001769)2.08537727
90Abnormality of the diencephalon (HP:0010662)2.07818193
91Anomalous pulmonary venous return (HP:0010772)2.07626331
92Hypoplasia of the corpus callosum (HP:0002079)2.06641802
93Submucous cleft hard palate (HP:0000176)2.03704501
94Overriding aorta (HP:0002623)2.02013232
95Progressive macrocephaly (HP:0004481)2.00960482
96Exotropia (HP:0000577)2.00343917
97Rib fusion (HP:0000902)2.00202886
98Chronic hepatic failure (HP:0100626)2.00177151
99Increased IgM level (HP:0003496)1.98738071
100Hyperventilation (HP:0002883)1.98458699
101Septo-optic dysplasia (HP:0100842)1.98032295
102Urinary bladder sphincter dysfunction (HP:0002839)1.97664642
103Bile duct proliferation (HP:0001408)1.96975124
104Abnormal biliary tract physiology (HP:0012439)1.96975124
105Abnormality of the renal medulla (HP:0100957)1.96766387
106Spastic gait (HP:0002064)1.96048370
107Supranuclear gaze palsy (HP:0000605)1.95895724
108Anxiety (HP:0000739)1.94989021
109Increased hepatocellular lipid droplets (HP:0006565)1.93307544
110Optic nerve coloboma (HP:0000588)1.93055394
111Psychosis (HP:0000709)1.93050383
112Torticollis (HP:0000473)1.92006652
113Meningocele (HP:0002435)1.91233724
114Fair hair (HP:0002286)1.91181971
115Genital tract atresia (HP:0001827)1.90794897
116Amblyopia (HP:0000646)1.89964296
117Vaginal atresia (HP:0000148)1.89730954
118Optic nerve hypoplasia (HP:0000609)1.89712790
119Broad-based gait (HP:0002136)1.89262668
120Abnormality of dental color (HP:0011073)1.88591396
121Hyperthyroidism (HP:0000836)1.88283099
122Apathy (HP:0000741)1.86398690
123Adrenal hypoplasia (HP:0000835)1.86209625
124Aplasia/Hypoplasia of the lens (HP:0008063)1.85100185
125Hypsarrhythmia (HP:0002521)1.84847286
126Epileptiform EEG discharges (HP:0011182)1.83946045
127Mutism (HP:0002300)1.83431865
128Blue irides (HP:0000635)1.82196112
129Poor coordination (HP:0002370)1.82024425
130Progressive inability to walk (HP:0002505)1.81577085
131Optic disc pallor (HP:0000543)1.81094035
132Abnormality of the pulmonary veins (HP:0011718)1.81005769
133Chorioretinal coloboma (HP:0000567)1.79966463
134Progressive cerebellar ataxia (HP:0002073)1.79914434
135EEG with generalized epileptiform discharges (HP:0011198)1.79677222
136Short foot (HP:0001773)1.79360397
137Postaxial hand polydactyly (HP:0001162)1.79122217
138Decreased testicular size (HP:0008734)1.79121884
139Increased CSF lactate (HP:0002490)1.78849352
140Hemiparesis (HP:0001269)1.78171663
141Generalized hypopigmentation (HP:0007513)1.78112430
142Hyperacusis (HP:0010780)1.77892824
143Narrow forehead (HP:0000341)1.77747905
144Growth hormone excess (HP:0000845)1.77282291
145Akinesia (HP:0002304)1.77127749
146Ankle clonus (HP:0011448)1.77031402
147Median cleft lip (HP:0000161)1.76748224
148Decreased central vision (HP:0007663)1.76641331
1493-Methylglutaconic aciduria (HP:0003535)1.76313689
150Abnormality of incisor morphology (HP:0011063)1.75242447
151Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75191214
152Hypocalcemia (HP:0002901)1.75031044
153Limb dystonia (HP:0002451)1.74968244
154Impaired vibration sensation in the lower limbs (HP:0002166)1.74601362
155Renal hypoplasia (HP:0000089)1.74444870
156Diminished motivation (HP:0000745)1.73695977
157Oligodactyly (hands) (HP:0001180)1.72297782
158Limb hypertonia (HP:0002509)1.71349452
159Prominent nasal bridge (HP:0000426)1.71077107
160Tubulointerstitial nephritis (HP:0001970)1.70089692
161Renal Fanconi syndrome (HP:0001994)1.69063329
162Nasal speech (HP:0001611)1.67942953
163Atelectasis (HP:0100750)1.66747523
164Generalized hypopigmentation of hair (HP:0011358)1.65649435
165Protruding tongue (HP:0010808)1.65533658
166Optic neuritis (HP:0100653)1.64172370
167Retrobulbar optic neuritis (HP:0100654)1.64172370
168Congenital sensorineural hearing impairment (HP:0008527)1.63641387
169Microvesicular hepatic steatosis (HP:0001414)1.62449273
170Abnormal pupillary function (HP:0007686)1.62134536
171Visual hallucinations (HP:0002367)1.61514995
172Fetal akinesia sequence (HP:0001989)1.61373058
173Hypogonadotrophic hypogonadism (HP:0000044)1.60502664

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.29684566
2NTRK34.17494391
3MAP2K73.57493963
4SIK33.51417194
5CASK3.36770112
6GRK73.29304179
7DYRK23.14907973
8MAP3K42.97586701
9ADRBK22.81559154
10TYRO32.21966428
11MARK12.19148032
12MAP4K22.18758738
13NTRK22.13256728
14TNIK2.12126756
15ARAF1.99784644
16MAP2K41.99272771
17EPHA31.91373343
18TNK21.89909855
19MAPK131.68121148
20SIK21.63318564
21MKNK21.50496249
22ICK1.39769134
23PIM21.36005531
24AKT31.35592356
25BCKDK1.32730541
26PRPF4B1.23308891
27BMPR21.22626588
28EPHA41.19956126
29CLK11.19816829
30DYRK1B1.17138647
31MARK21.14485336
32LIMK11.12972921
33MINK11.10677410
34TRIM281.10438217
35PLK21.09265885
36BMPR1B1.09025205
37LMTK21.07365200
38MAP3K131.07269946
39ADRBK11.06777920
40PAK31.05891671
41TXK1.05697541
42BRAF1.02893077
43CSNK1G11.01654817
44DYRK30.96797108
45SGK20.96287016
46BCR0.96030633
47CAMK2A0.94947838
48PNCK0.94659942
49YES10.92325213
50CDK30.92063425
51PRKCE0.87479412
52MARK30.86325367
53PRKCG0.86004177
54TSSK60.85656443
55BRD40.82055302
56MAP3K100.81795810
57NME10.81763723
58SGK2230.81231252
59SGK4940.81231252
60ROCK10.80627535
61IRAK40.80326368
62ERBB30.78694505
63CAMK2G0.77631408
64RPS6KA20.75746772
65NEK60.74711025
66IRAK30.71100507
67CDK140.70772855
68OXSR10.69449482
69WNK30.68971210
70FES0.68489975
71KSR10.68477298
72CAMK10.67620436
73PRKD30.67329967
74UHMK10.66425333
75CDK11A0.66237948
76RIPK40.65173218
77CDK180.64807487
78INSRR0.64727870
79MAP3K90.63728036
80STK160.63240323
81CDK150.62904355
82CDK190.62705939
83MAP3K140.61637281
84STK38L0.60478476
85PRKCZ0.59338824
86MAPK150.58973820
87PKN10.58782837
88CDK50.58572046
89RPS6KA50.58061461
90IRAK20.56775540
91IRAK10.56453388
92FRK0.55602426
93CSNK1D0.55594860
94PAK60.55378555
95VRK10.53969087
96BLK0.53411407
97ERBB20.52537815
98GRK50.52224522
99MST1R0.52148222
100SGK10.49924047
101MUSK0.49402483
102MKNK10.49215559
103ZAK0.48445056
104GRK10.48306783
105SYK0.48220239
106CAMK2D0.48170700
107MAP3K60.47310767
108STK380.46792169
109PRKG10.45279943
110DYRK1A0.43587075
111CSNK1A1L0.42804498
112MAP3K10.42066894
113PRKCI0.41860730
114FGFR20.41611793
115STK110.41577424
116PRKACA0.41571003
117EPHA20.41569548
118RPS6KA40.40279315
119PINK10.39660708
120AURKA0.39644596
121TEC0.39550546
122WNK40.39218928
123SRPK10.38961465
124MYLK0.38510002
125PDGFRB0.38341295
126PHKG20.37886042
127PHKG10.37886042
128LATS20.37412768
129CAMK2B0.36867115
130TIE10.36776092
131EPHB20.36249242
132CAMK40.36007525
133CSNK1G20.35770544
134GSK3B0.35427713
135CSNK1G30.34655341
136NTRK10.34398270
137CSK0.34395103
138EIF2AK20.34224977
139ALK0.32774431
140EGFR0.32458012
141CSNK1E0.30038286
142PRKAA10.29508528
143FER0.29482302
144INSR0.29411181
145FGFR40.29025170
146PRKACB0.28996479
147MAPK100.26764658

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.67066821
2Oxidative phosphorylation_Homo sapiens_hsa001903.27363767
3Synaptic vesicle cycle_Homo sapiens_hsa047212.75429111
4GABAergic synapse_Homo sapiens_hsa047272.74189697
5Collecting duct acid secretion_Homo sapiens_hsa049662.72771352
6Taste transduction_Homo sapiens_hsa047422.68678085
7Morphine addiction_Homo sapiens_hsa050322.67206089
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62309734
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.52974421
10Parkinsons disease_Homo sapiens_hsa050122.38436710
11Alcoholism_Homo sapiens_hsa050342.24114647
12Olfactory transduction_Homo sapiens_hsa047402.21753209
13Circadian entrainment_Homo sapiens_hsa047132.09316575
14Alzheimers disease_Homo sapiens_hsa050102.07428190
15Serotonergic synapse_Homo sapiens_hsa047262.01494658
16Vibrio cholerae infection_Homo sapiens_hsa051101.91235684
17Glutamatergic synapse_Homo sapiens_hsa047241.90475376
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.81091053
19Notch signaling pathway_Homo sapiens_hsa043301.79332108
20Rheumatoid arthritis_Homo sapiens_hsa053231.78887232
21Huntingtons disease_Homo sapiens_hsa050161.77893537
22Insulin secretion_Homo sapiens_hsa049111.75032228
23Amphetamine addiction_Homo sapiens_hsa050311.68773316
24Cocaine addiction_Homo sapiens_hsa050301.66220366
25Type I diabetes mellitus_Homo sapiens_hsa049401.65281031
26Long-term depression_Homo sapiens_hsa047301.62288226
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57654330
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49197726
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.48647528
30Cardiac muscle contraction_Homo sapiens_hsa042601.48565950
31Renin secretion_Homo sapiens_hsa049241.42813312
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40251497
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39706651
34Dopaminergic synapse_Homo sapiens_hsa047281.37647489
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36893978
36Salivary secretion_Homo sapiens_hsa049701.31797735
37Long-term potentiation_Homo sapiens_hsa047201.29353962
38Calcium signaling pathway_Homo sapiens_hsa040201.27502150
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26396219
40Butanoate metabolism_Homo sapiens_hsa006501.22405705
41Cholinergic synapse_Homo sapiens_hsa047251.21034432
42Protein export_Homo sapiens_hsa030601.18318621
43Gastric acid secretion_Homo sapiens_hsa049711.12114089
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05890824
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00947667
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00268568
47Oxytocin signaling pathway_Homo sapiens_hsa049211.00115737
48Nitrogen metabolism_Homo sapiens_hsa009100.98492179
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98293266
50Graft-versus-host disease_Homo sapiens_hsa053320.97597941
51Hippo signaling pathway_Homo sapiens_hsa043900.97536529
52Ovarian steroidogenesis_Homo sapiens_hsa049130.95701014
53Oocyte meiosis_Homo sapiens_hsa041140.94465204
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92022007
55Phototransduction_Homo sapiens_hsa047440.89511681
56cAMP signaling pathway_Homo sapiens_hsa040240.89118954
57Phagosome_Homo sapiens_hsa041450.89099720
58Axon guidance_Homo sapiens_hsa043600.88040757
59GnRH signaling pathway_Homo sapiens_hsa049120.87805825
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87046080
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84368071
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83287686
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81896282
64Linoleic acid metabolism_Homo sapiens_hsa005910.80318597
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78337261
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77888081
67Steroid biosynthesis_Homo sapiens_hsa001000.75902326
68ErbB signaling pathway_Homo sapiens_hsa040120.74451477
69AMPK signaling pathway_Homo sapiens_hsa041520.73165482
70Melanogenesis_Homo sapiens_hsa049160.72860072
71Autoimmune thyroid disease_Homo sapiens_hsa053200.72837242
72Prion diseases_Homo sapiens_hsa050200.72312366
73Allograft rejection_Homo sapiens_hsa053300.71494456
74Tryptophan metabolism_Homo sapiens_hsa003800.70322581
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70115076
76Estrogen signaling pathway_Homo sapiens_hsa049150.67439808
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66250230
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.65228392
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.65129047
80Basal cell carcinoma_Homo sapiens_hsa052170.63520554
81African trypanosomiasis_Homo sapiens_hsa051430.63172157
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62643823
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61597904
84Systemic lupus erythematosus_Homo sapiens_hsa053220.60626479
85Hedgehog signaling pathway_Homo sapiens_hsa043400.59955041
86Sphingolipid metabolism_Homo sapiens_hsa006000.59902656
87Dilated cardiomyopathy_Homo sapiens_hsa054140.58413290
88MAPK signaling pathway_Homo sapiens_hsa040100.57442727
89Colorectal cancer_Homo sapiens_hsa052100.57403597
90Melanoma_Homo sapiens_hsa052180.55862298
91Phenylalanine metabolism_Homo sapiens_hsa003600.54890025
92Gap junction_Homo sapiens_hsa045400.54385876
93Dorso-ventral axis formation_Homo sapiens_hsa043200.52606324
94Wnt signaling pathway_Homo sapiens_hsa043100.51928280
95Type II diabetes mellitus_Homo sapiens_hsa049300.51785947
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51068588
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50073564
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.49530172
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48351252
100Ras signaling pathway_Homo sapiens_hsa040140.47155680
101Ether lipid metabolism_Homo sapiens_hsa005650.41937917
102Endometrial cancer_Homo sapiens_hsa052130.41880124
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41859928
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41780454
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41034050
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40358171
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39141558
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38847662
109Thyroid hormone synthesis_Homo sapiens_hsa049180.38197797
110Peroxisome_Homo sapiens_hsa041460.37636383
111Rap1 signaling pathway_Homo sapiens_hsa040150.36894957
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36232003
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36013308
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.35085337
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33977579
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33677414
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.33638544
118Caffeine metabolism_Homo sapiens_hsa002320.33608215
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32814277
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31560094
121Tight junction_Homo sapiens_hsa045300.31300991
122Circadian rhythm_Homo sapiens_hsa047100.27876309
123Regulation of autophagy_Homo sapiens_hsa041400.27192469
124Pancreatic secretion_Homo sapiens_hsa049720.24315470
125Mineral absorption_Homo sapiens_hsa049780.23516634
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.23263395
127Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.22925078
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22431438
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22015985
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21765653
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.21626944
132Prolactin signaling pathway_Homo sapiens_hsa049170.21150526
133Arachidonic acid metabolism_Homo sapiens_hsa005900.20760685
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20532386
135Inositol phosphate metabolism_Homo sapiens_hsa005620.19742462
136Chemokine signaling pathway_Homo sapiens_hsa040620.18730315

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »