OTUD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)6.06458920
2muscle filament sliding (GO:0030049)5.54923192
3actin-myosin filament sliding (GO:0033275)5.54923192
4response to peptidoglycan (GO:0032494)5.49346075
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.41582063
6sarcomere organization (GO:0045214)5.07543524
7desmosome organization (GO:0002934)4.94053743
8actin-mediated cell contraction (GO:0070252)4.70663811
9sarcoplasmic reticulum calcium ion transport (GO:0070296)4.65990752
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.41780181
11establishment of skin barrier (GO:0061436)4.39315433
12myofibril assembly (GO:0030239)4.28131156
13positive regulation by symbiont of host defense response (GO:0052509)4.26905228
14modulation by symbiont of host defense response (GO:0052031)4.26905228
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.26905228
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.26905228
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.26905228
18modulation by symbiont of host immune response (GO:0052553)4.26905228
19cardiac muscle hypertrophy (GO:0003300)4.23368361
20neutrophil activation involved in immune response (GO:0002283)4.21375653
21response to muramyl dipeptide (GO:0032495)4.20742194
22negative regulation of interleukin-12 production (GO:0032695)4.14908444
23regulation of water loss via skin (GO:0033561)4.12678517
24striated muscle hypertrophy (GO:0014897)4.08152426
25cardiac myofibril assembly (GO:0055003)4.05073922
26plasma membrane repair (GO:0001778)4.03298867
27lipopolysaccharide-mediated signaling pathway (GO:0031663)3.98332924
28actin filament-based movement (GO:0030048)3.96487990
29cellular extravasation (GO:0045123)3.84906780
30regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.81952387
31skeletal muscle contraction (GO:0003009)3.70464088
32bundle of His cell to Purkinje myocyte communication (GO:0086069)3.67184383
33G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.64267050
34skeletal muscle adaptation (GO:0043501)3.60077698
35cardiac muscle cell development (GO:0055013)3.59413096
36muscle hypertrophy (GO:0014896)3.59098747
37cardiac cell development (GO:0055006)3.55036540
38regulation of gamma-delta T cell activation (GO:0046643)3.48933674
39regulation of T-helper 1 cell differentiation (GO:0045625)3.48236915
40striated muscle adaptation (GO:0014888)3.48058203
41germinal center formation (GO:0002467)3.47678341
42regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.45455895
43regulation of T-helper 2 cell differentiation (GO:0045628)3.42822592
44cardiac muscle adaptation (GO:0014887)3.42666654
45cardiac muscle hypertrophy in response to stress (GO:0014898)3.42666654
46muscle hypertrophy in response to stress (GO:0003299)3.42666654
47positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.41409007
48macrophage activation (GO:0042116)3.39827278
49detection of other organism (GO:0098543)3.39405041
50positive regulation of chemokine secretion (GO:0090197)3.36093589
51regulation of interleukin-8 biosynthetic process (GO:0045414)3.35080914
52immunoglobulin mediated immune response (GO:0016064)3.34780331
53striated muscle contraction (GO:0006941)3.32712175
54skeletal muscle fiber development (GO:0048741)3.30708917
55regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.30566429
56detection of molecule of bacterial origin (GO:0032490)3.30396063
57regulation of interferon-alpha production (GO:0032647)3.29389793
58negative regulation of erythrocyte differentiation (GO:0045647)3.27872293
59regulation of germinal center formation (GO:0002634)3.27002720
60hepatocyte apoptotic process (GO:0097284)3.23914451
61positive regulation of cardiac muscle cell differentiation (GO:2000727)3.23891974
62granulocyte activation (GO:0036230)3.22806570
63positive regulation of interferon-alpha production (GO:0032727)3.22105843
64positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.21789256
65actomyosin structure organization (GO:0031032)3.20506186
66response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.20300355
67ventricular cardiac muscle cell action potential (GO:0086005)3.18523021
68germ cell migration (GO:0008354)3.18004088
69skeletal muscle tissue regeneration (GO:0043403)3.15872901
70striated muscle atrophy (GO:0014891)3.15727522
71regulation of vitamin D biosynthetic process (GO:0060556)3.14564141
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.14166076
73positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.12060804
74regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.11367182
75regulation of chemokine secretion (GO:0090196)3.09281740
76myeloid cell activation involved in immune response (GO:0002275)3.08477738
77myotube cell development (GO:0014904)3.06922728
78neutrophil mediated immunity (GO:0002446)3.05214353
79neutrophil activation (GO:0042119)3.02892467
80detection of bacterium (GO:0016045)3.02429258
81negative regulation of potassium ion transmembrane transport (GO:1901380)3.01007860
82leukocyte aggregation (GO:0070486)3.00577920
83keratinization (GO:0031424)2.99069359
84regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.98217690
85cardiac muscle tissue morphogenesis (GO:0055008)2.98055227
86negative regulation of cytokine production involved in immune response (GO:0002719)2.97931478
87chemical homeostasis within a tissue (GO:0048875)2.97644693
88positive regulation of chemokine biosynthetic process (GO:0045080)2.97607250
89T-helper 1 type immune response (GO:0042088)2.95768077
90regulation of cell communication by electrical coupling (GO:0010649)2.92791720
91regulation of alkaline phosphatase activity (GO:0010692)2.92778120
92cardiac muscle contraction (GO:0060048)2.92695381
93positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.92616246
94detection of biotic stimulus (GO:0009595)2.91769523
95negative regulation of T cell mediated immunity (GO:0002710)2.90920111
96negative regulation of stress fiber assembly (GO:0051497)2.90554743
97detection of external biotic stimulus (GO:0098581)2.90342087
98negative regulation of inclusion body assembly (GO:0090084)2.89039698
99positive thymic T cell selection (GO:0045059)2.88773806
100negative regulation of cAMP-mediated signaling (GO:0043951)2.86698361
101muscle fiber development (GO:0048747)2.86259593
102regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.85670926
103muscle adaptation (GO:0043500)2.84859185
104defense response to protozoan (GO:0042832)2.84145253
105regulation of striated muscle contraction (GO:0006942)2.83583347
106striated muscle cell development (GO:0055002)2.83137407
107neutrophil chemotaxis (GO:0030593)2.82789636
108negative regulation of skeletal muscle tissue development (GO:0048642)2.82496809
109negative regulation of T-helper cell differentiation (GO:0045623)2.82048150
110negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82048150
111monocyte differentiation (GO:0030224)2.81766993
112cardiac right ventricle morphogenesis (GO:0003215)2.81073611
113myeloid leukocyte mediated immunity (GO:0002444)2.80885231
114negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.79925456
115negative regulation of cell killing (GO:0031342)2.79925456
116positive regulation of gamma-delta T cell activation (GO:0046645)2.79179874
117CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.78947493
118T-helper cell differentiation (GO:0042093)2.78947493
119muscle cell cellular homeostasis (GO:0046716)2.77812401
120antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77267762
121protein localization to endosome (GO:0036010)2.77188199
122regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.77144072
123muscle tissue morphogenesis (GO:0060415)2.76577444
124neutrophil migration (GO:1990266)2.75561573
125regulation of sarcomere organization (GO:0060297)2.75160532
126microglial cell activation (GO:0001774)2.74207891
127antigen processing and presentation of endogenous antigen (GO:0019883)2.72709174
128interferon-gamma-mediated signaling pathway (GO:0060333)2.72084238
129negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.71995973
130regulation of interferon-beta biosynthetic process (GO:0045357)2.71448726
131establishment of endothelial barrier (GO:0061028)2.69662309
132positive regulation of interleukin-2 production (GO:0032743)2.69446532
133negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.69285768
134response to protozoan (GO:0001562)2.69259925
135regulation of relaxation of muscle (GO:1901077)2.69041474
136response to host immune response (GO:0052572)2.69036300
137response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.69036300
138response to inactivity (GO:0014854)2.68023103
139negative regulation of lymphocyte mediated immunity (GO:0002707)2.67410471
140positive regulation of type 2 immune response (GO:0002830)2.67287035
141keratinocyte differentiation (GO:0030216)2.66730689
142production of molecular mediator involved in inflammatory response (GO:0002532)2.65805154
143regulation of chemokine biosynthetic process (GO:0045073)2.64973022
144regulation of gamma-delta T cell differentiation (GO:0045586)2.64596974
145cellular response to arsenic-containing substance (GO:0071243)2.64459981
146antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.62781421
147regulation of dendritic cell antigen processing and presentation (GO:0002604)2.62605235
148regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.62440593
149heart trabecula formation (GO:0060347)2.62099795
150regulation of mast cell degranulation (GO:0043304)2.62013330
151positive regulation of interleukin-1 beta secretion (GO:0050718)2.61940736
152pathway-restricted SMAD protein phosphorylation (GO:0060389)2.61260595
153positive regulation of interferon-beta production (GO:0032728)2.60534429
154negative regulation of interleukin-6 production (GO:0032715)2.60472035
155positive regulation of mast cell activation (GO:0033005)2.60132095
156positive regulation of B cell differentiation (GO:0045579)2.58504418
157positive regulation of interleukin-6 production (GO:0032755)2.57703526
158negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.57528387
159coronary vasculature morphogenesis (GO:0060977)2.57487186
160tolerance induction (GO:0002507)2.57219212
161positive regulation of cellular amide metabolic process (GO:0034250)2.56915009
162cytidine metabolic process (GO:0046087)2.56903856
163cytidine catabolic process (GO:0006216)2.56903856
164cytidine deamination (GO:0009972)2.56903856
165regulation of B cell receptor signaling pathway (GO:0050855)2.56889634
166regulation of interleukin-12 production (GO:0032655)2.56137993
167fibroblast migration (GO:0010761)2.55929670
168regulation of T-helper cell differentiation (GO:0045622)2.55175243
169positive regulation of heat generation (GO:0031652)2.54154901
170regulation of interleukin-6 production (GO:0032675)2.53982393
171muscle contraction (GO:0006936)2.53942397
172negative regulation of interleukin-8 production (GO:0032717)2.53760603
173regulation of type 2 immune response (GO:0002828)2.53209302
174response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.52314332
175response to host defenses (GO:0052200)2.52314332
176negative regulation of systemic arterial blood pressure (GO:0003085)2.52246178
177surfactant homeostasis (GO:0043129)2.51686058
178positive regulation of myoblast differentiation (GO:0045663)2.50963133
179hemidesmosome assembly (GO:0031581)2.50883498
1803-UTR-mediated mRNA stabilization (GO:0070935)2.49110377
181muscle cell development (GO:0055001)2.48909145
182multicellular organismal water homeostasis (GO:0050891)2.47788397
183muscle system process (GO:0003012)2.47722962
184macrophage activation involved in immune response (GO:0002281)2.46803714
185cardiac muscle cell action potential (GO:0086001)2.46288821
186cell-substrate junction assembly (GO:0007044)2.45427629
187regulation of interleukin-12 biosynthetic process (GO:0045075)2.44926205

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.26797172
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.11128407
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.59130367
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.32194655
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.02706676
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.01342649
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.66394392
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.45079426
9VDR_24763502_ChIP-Seq_THP-1_Human2.24673304
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.14541908
11RUNX_20019798_ChIP-Seq_JUKART_Human2.12151924
12ZNF263_19887448_ChIP-Seq_K562_Human2.10472034
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.07665421
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05211967
15SCL_19346495_ChIP-Seq_HPC-7_Human2.02178161
16ESR1_20079471_ChIP-ChIP_T-47D_Human1.99702570
17ESR1_21235772_ChIP-Seq_MCF-7_Human1.98732705
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.96269637
19* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93465169
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90812368
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.90790298
22* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86111884
23SOX9_24532713_ChIP-Seq_HFSC_Mouse1.84805698
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.83147326
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82966343
26TCF7_22412390_ChIP-Seq_EML_Mouse1.82693784
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.81530436
28* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80122813
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79349490
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.74994096
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71215467
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70825468
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.69052106
34* TBX20_22328084_ChIP-Seq_HEART_Mouse1.68469051
35* TBX20_22080862_ChIP-Seq_HEART_Mouse1.68469051
36* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67557547
37VDR_21846776_ChIP-Seq_THP-1_Human1.63721832
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63450596
39* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62167545
40SPI1_23547873_ChIP-Seq_NB4_Human1.58994302
41* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58773488
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.58318307
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.54903025
44TCF4_18268006_ChIP-ChIP_LS174T_Human1.53971479
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.53608658
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.53566880
47KDM2B_26808549_Chip-Seq_DND41_Human1.53123612
48CJUN_26792858_Chip-Seq_BT549_Human1.50571541
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50528484
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50469243
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.47255599
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.47255599
53RUNX1_27514584_Chip-Seq_MCF-7_Human1.45480489
54NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44307174
55* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43884110
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.43065300
57P63_26484246_Chip-Seq_KERATINOCYTES_Human1.41538308
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41187645
59* MAF_26560356_Chip-Seq_TH1_Human1.38881113
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37465609
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35788555
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35563607
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35434217
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32706271
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32706271
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32706271
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31401146
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29255533
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28877498
70RXR_22108803_ChIP-Seq_LS180_Human1.26818828
71* ATF3_27146783_Chip-Seq_COLON_Human1.25865070
72MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24870843
73* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24209078
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.23938063
75JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23101099
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22325019
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22324323
78CLOCK_20551151_ChIP-Seq_293T_Human1.21015999
79VDR_24787735_ChIP-Seq_THP-1_Human1.20375099
80TP53_16413492_ChIP-PET_HCT116_Human1.20275998
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20107727
82* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19965292
83* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18812751
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.17767541
85GATA3_27048872_Chip-Seq_THYMUS_Human1.16863888
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16548389
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16509140
88MYC_22102868_ChIP-Seq_BL_Human1.16380669
89TRIM28_21343339_ChIP-Seq_HEK293_Human1.16030453
90GATA1_22025678_ChIP-Seq_K562_Human1.15369032
91TP63_23658742_ChIP-Seq_EP156T_Human1.14630075
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13954644
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12104510
94GATA2_19941826_ChIP-Seq_K562_Human1.11413998
95BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11159570
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10510209
97* UBF1/2_26484160_Chip-Seq_HMECs_Human1.09933972
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.09623170
99GATA1_19941826_ChIP-Seq_K562_Human1.09243488
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08968159
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07737654
102GATA1_19941827_ChIP-Seq_MEL_Mouse1.07186070
103STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06100309
104MYB_26560356_Chip-Seq_TH1_Human1.05536457
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05462194
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04183936
107KLF5_25053715_ChIP-Seq_YYC3_Human1.02494756
108FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02483032
109JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98327910
110BCAT_22108803_ChIP-Seq_LS180_Human0.97368983
111PU_27001747_Chip-Seq_BMDM_Mouse0.97004531
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96555634
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96344277
114KDM2B_26808549_Chip-Seq_K562_Human0.96069363
115* RACK7_27058665_Chip-Seq_MCF-7_Human0.95774914
116GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95551717
117* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95507179
118CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95373035
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95245344
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.93374664
121TP53_18474530_ChIP-ChIP_U2OS_Human0.93164407
122SPI1_23127762_ChIP-Seq_K562_Human0.92892393
123AHR_22903824_ChIP-Seq_MCF-7_Human0.91752115
124LXR_22158963_ChIP-Seq_LIVER_Mouse0.91603584
125PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91420317
126BRD4_25478319_ChIP-Seq_HGPS_Human0.91397246
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91089148
128CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90781830
129P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90428170
130UTX_26944678_Chip-Seq_JUKART_Human0.90287348
131SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90005991
132NCOR1_26117541_ChIP-Seq_K562_Human0.89560793
133CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89473561
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.88293069
135GATA3_26560356_Chip-Seq_TH2_Human0.87625890
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86891083
137* MYB_26560356_Chip-Seq_TH2_Human0.86858480
138* SMRT_27268052_Chip-Seq_Bcells_Human0.86667296
139MAF_26560356_Chip-Seq_TH2_Human0.83728870
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81502690
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80264636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development3.70838321
2MP0002796_impaired_skin_barrier3.31127162
3MP0003724_increased_susceptibility_to3.29523419
4MP0000751_myopathy3.21622733
5MP0003191_abnormal_cellular_cholesterol3.19679875
6MP0004510_myositis3.12558411
7MP0001835_abnormal_antigen_presentation3.05350045
8MP0000749_muscle_degeneration2.96437103
9MP0004145_abnormal_muscle_electrophysio2.95500816
10MP0002148_abnormal_hypersensitivity_rea2.94018829
11MP0003646_muscle_fatigue2.75932277
12MP0009785_altered_susceptibility_to2.75231356
13MP0003828_pulmonary_edema2.75004259
14MP0009278_abnormal_bone_marrow2.67013330
15MP0002419_abnormal_innate_immunity2.63201470
16MP0000750_abnormal_muscle_regeneration2.56950100
17MP0005000_abnormal_immune_tolerance2.53895970
18MP0004087_abnormal_muscle_fiber2.38610668
19MP0005025_abnormal_response_to2.31849093
20MP0005330_cardiomyopathy2.25112046
21MP0005451_abnormal_body_composition2.23424473
22MP0004484_altered_response_of2.21710620
23MP0004084_abnormal_cardiac_muscle2.21011299
24MP0002106_abnormal_muscle_physiology2.18679040
25MP0002723_abnormal_immune_serum2.16616468
26MP0004215_abnormal_myocardial_fiber2.08585715
27MP0003566_abnormal_cell_adhesion2.07497782
28MP0010234_abnormal_vibrissa_follicle2.05710846
29MP0000747_muscle_weakness2.01804368
30MP0010630_abnormal_cardiac_muscle1.94326739
31MP0002837_dystrophic_cardiac_calcinosis1.94289876
32MP0002269_muscular_atrophy1.93876711
33MP0004036_abnormal_muscle_relaxation1.92141337
34MP0002420_abnormal_adaptive_immunity1.88855183
35MP0005620_abnormal_muscle_contractility1.88849120
36MP0004947_skin_inflammation1.87618868
37MP0005058_abnormal_lysosome_morphology1.87410308
38MP0004185_abnormal_adipocyte_glucose1.86990843
39MP0001819_abnormal_immune_cell1.85878985
40MP0005275_abnormal_skin_tensile1.84645718
41MP0005670_abnormal_white_adipose1.84212768
42MP0009764_decreased_sensitivity_to1.82671390
43MP0003453_abnormal_keratinocyte_physiol1.81815218
44MP0002972_abnormal_cardiac_muscle1.78744346
45MP0005501_abnormal_skin_physiology1.78737316
46MP0001533_abnormal_skeleton_physiology1.76694624
47MP0003950_abnormal_plasma_membrane1.75959730
48MP0003045_fibrosis1.75546758
49MP0004130_abnormal_muscle_cell1.73154374
50MP0002998_abnormal_bone_remodeling1.68694883
51MP0005166_decreased_susceptibility_to1.68474578
52MP0003075_altered_response_to1.67113159
53MP0005369_muscle_phenotype1.63796666
54MP0003172_abnormal_lysosome_physiology1.63742330
55MP0009840_abnormal_foam_cell1.63295645
56MP0000759_abnormal_skeletal_muscle1.58787639
57MP0002405_respiratory_system_inflammati1.58407767
58MP0008004_abnormal_stomach_pH1.56491434
59MP0002254_reproductive_system_inflammat1.56412599
60MP0010155_abnormal_intestine_physiology1.54986050
61MP0002006_tumorigenesis1.54886125
62MP0001845_abnormal_inflammatory_respons1.54628731
63MP0002877_abnormal_melanocyte_morpholog1.52973773
64MP0003303_peritoneal_inflammation1.52898217
65MP0001544_abnormal_cardiovascular_syste1.48379627
66MP0005385_cardiovascular_system_phenoty1.48379627
67MP0001216_abnormal_epidermal_layer1.47440391
68MP0005666_abnormal_adipose_tissue1.42472474
69MP0000733_abnormal_muscle_development1.41948966
70MP0003656_abnormal_erythrocyte_physiolo1.40913305
71MP0004883_abnormal_blood_vessel1.38676768
72MP0003705_abnormal_hypodermis_morpholog1.37999535
73MP0009333_abnormal_splenocyte_physiolog1.34504615
74MP0000716_abnormal_immune_system1.32945433
75MP0008469_abnormal_protein_level1.32105161
76MP0002060_abnormal_skin_morphology1.29354748
77MP0005164_abnormal_response_to1.28028773
78MP0003690_abnormal_glial_cell1.26248537
79MP0002332_abnormal_exercise_endurance1.25562945
80MP0005167_abnormal_blood-brain_barrier1.24100399
81MP0002398_abnormal_bone_marrow1.23856320
82MP0005023_abnormal_wound_healing1.23521548
83MP0004381_abnormal_hair_follicle1.22602264
84MP0003195_calcinosis1.22475496
85MP0005076_abnormal_cell_differentiation1.21182692
86MP0000767_abnormal_smooth_muscle1.19395318
87MP0004808_abnormal_hematopoietic_stem1.17395570
88MP0001851_eye_inflammation1.15660593
89MP0002127_abnormal_cardiovascular_syste1.14877455
90MP0002138_abnormal_hepatobiliary_system1.13691277
91MP0000343_altered_response_to1.11633346
92MP0003221_abnormal_cardiomyocyte_apopto1.10834042
93MP0005310_abnormal_salivary_gland1.08612867
94MP0006138_congestive_heart_failure1.07604637
95MP0003137_abnormal_impulse_conducting1.05434115
96MP0000689_abnormal_spleen_morphology1.04819942
97MP0000858_altered_metastatic_potential1.04608615
98MP0003448_altered_tumor_morphology1.04584947
99MP0001800_abnormal_humoral_immune1.03500282
100MP0005397_hematopoietic_system_phenotyp1.03384754
101MP0001545_abnormal_hematopoietic_system1.03384754
102MP0000465_gastrointestinal_hemorrhage1.02661315
103MP0006082_CNS_inflammation1.02619115
104MP0003300_gastrointestinal_ulcer1.02188432
105MP0009384_cardiac_valve_regurgitation0.99686713
106MP0008260_abnormal_autophagy0.98832032
107MP0005387_immune_system_phenotype0.98758220
108MP0001790_abnormal_immune_system0.98758220
109MP0002971_abnormal_brown_adipose0.98743187
110MP0002277_abnormal_respiratory_mucosa0.97703646
111MP0003091_abnormal_cell_migration0.97320587
112MP0003279_aneurysm0.97198742
113MP0000604_amyloidosis0.96896881
114MP0002722_abnormal_immune_system0.96549168
115MP0002429_abnormal_blood_cell0.94644615
116MP0010678_abnormal_skin_adnexa0.92727428
117MP0000249_abnormal_blood_vessel0.91505091
118MP0001191_abnormal_skin_condition0.90776780
119MP0008961_abnormal_basal_metabolism0.90601718
120MP0002452_abnormal_antigen_presenting0.90438052
121MP0000377_abnormal_hair_follicle0.90108003
122MP0000383_abnormal_hair_follicle0.89674778
123MP0009931_abnormal_skin_appearance0.89447139
124MP0010771_integument_phenotype0.89100586
125MP0002132_abnormal_respiratory_system0.88529187
126MP0002933_joint_inflammation0.88394543
127MP0001853_heart_inflammation0.87318512
128MP0003567_abnormal_fetal_cardiomyocyte0.87136031
129MP0010352_gastrointestinal_tract_polyps0.85821846
130MP0010368_abnormal_lymphatic_system0.85085245
131MP0000266_abnormal_heart_morphology0.84380511
132MP0005623_abnormal_meninges_morphology0.83051356
133MP0005390_skeleton_phenotype0.82827529
134MP0002009_preneoplasia0.82812925
135MP0003436_decreased_susceptibility_to0.82179649
136MP0001784_abnormal_fluid_regulation0.80054204
137MP0005165_increased_susceptibility_to0.79843172
138MP0005671_abnormal_response_to0.78457409
139MP0009763_increased_sensitivity_to0.77357778
140MP0005464_abnormal_platelet_physiology0.76787000
141MP0000685_abnormal_immune_system0.76381473
142MP0005375_adipose_tissue_phenotype0.76192819
143MP0003763_abnormal_thymus_physiology0.75966144
144MP0001879_abnormal_lymphatic_vessel0.75926856
145MP0002166_altered_tumor_susceptibility0.75886705
146MP0002925_abnormal_cardiovascular_devel0.75772851
147MP0006054_spinal_hemorrhage0.75767789
148MP0002168_other_aberrant_phenotype0.75719127
149MP0002098_abnormal_vibrissa_morphology0.75361534
150MP0002128_abnormal_blood_circulation0.75157502
151MP0004233_abnormal_muscle_weight0.74547792
152MP0009115_abnormal_fat_cell0.73822510
153MP0000569_abnormal_digit_pigmentation0.73099039
154MP0001873_stomach_inflammation0.70237689
155MP0001663_abnormal_digestive_system0.64866050
156MP0001542_abnormal_bone_strength0.63816536
157MP0000703_abnormal_thymus_morphology0.62512637

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)5.28709679
2Muscle fiber inclusion bodies (HP:0100299)5.26392009
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.26199028
4Recurrent bacterial skin infections (HP:0005406)5.04851166
5Stomatitis (HP:0010280)5.03961977
6Hyporeflexia of lower limbs (HP:0002600)5.03253236
7Sudden death (HP:0001699)5.00551371
8Calf muscle hypertrophy (HP:0008981)4.69510772
9Exercise-induced myalgia (HP:0003738)4.67608164
10Right ventricular cardiomyopathy (HP:0011663)4.64414523
11Recurrent abscess formation (HP:0002722)4.60110778
12Nemaline bodies (HP:0003798)4.47446522
13Muscle hypertrophy of the lower extremities (HP:0008968)4.47045574
14Abnormality of macrophages (HP:0004311)4.42719874
15Abnormality of the calf musculature (HP:0001430)4.35846699
16Exercise-induced muscle cramps (HP:0003710)4.35388795
17Type 1 muscle fiber predominance (HP:0003803)4.18988171
18Elevated erythrocyte sedimentation rate (HP:0003565)4.17975616
19Areflexia of lower limbs (HP:0002522)4.15135510
20Myositis (HP:0100614)4.13616880
21Ventricular tachycardia (HP:0004756)4.04301220
22Optic neuritis (HP:0100653)4.03567110
23Retrobulbar optic neuritis (HP:0100654)4.03567110
24Orchitis (HP:0100796)3.97411648
25Round ear (HP:0100830)3.96889800
26Increased connective tissue (HP:0009025)3.96537775
27Abnormality of the left ventricular outflow tract (HP:0011103)3.81763283
28Subaortic stenosis (HP:0001682)3.81763283
29EMG: myopathic abnormalities (HP:0003458)3.74485981
30Distal lower limb muscle weakness (HP:0009053)3.67970448
31Abnormality of glycolipid metabolism (HP:0010969)3.63175081
32Abnormality of liposaccharide metabolism (HP:0010968)3.63175081
33Abnormality of glycosphingolipid metabolism (HP:0004343)3.63175081
34Arterial tortuosity (HP:0005116)3.44810476
35Mediastinal lymphadenopathy (HP:0100721)3.35663648
36Amyloidosis (HP:0011034)3.35253460
37Spontaneous hematomas (HP:0007420)3.29748503
38Ulnar deviation of the wrist (HP:0003049)3.29233569
39Distal arthrogryposis (HP:0005684)3.29014136
40Malignant hyperthermia (HP:0002047)3.23713335
41Difficulty running (HP:0009046)3.22838700
42Difficulty climbing stairs (HP:0003551)3.20301257
43Recurrent skin infections (HP:0001581)3.14020100
44Recurrent gram-negative bacterial infections (HP:0005420)3.10527993
45Vascular tortuosity (HP:0004948)3.07009581
46Distal lower limb amyotrophy (HP:0008944)3.04366254
47Keratoconjunctivitis sicca (HP:0001097)2.99917829
48Syncope (HP:0001279)2.99127190
49Atrial fibrillation (HP:0005110)2.97005752
50Eczematoid dermatitis (HP:0000976)2.92720471
51Meningitis (HP:0001287)2.91812322
52Increased cerebral lipofuscin (HP:0011813)2.91504714
53Systemic lupus erythematosus (HP:0002725)2.88299991
54Recurrent fungal infections (HP:0002841)2.82278458
55Asymmetric septal hypertrophy (HP:0001670)2.80234033
56Vasculitis (HP:0002633)2.80027898
57Aortic aneurysm (HP:0004942)2.78128421
58Primary atrial arrhythmia (HP:0001692)2.76976883
59Increased IgE level (HP:0003212)2.76735407
60Keratoconjunctivitis (HP:0001096)2.74763405
61Recurrent viral infections (HP:0004429)2.72743156
62Lipoatrophy (HP:0100578)2.72226071
63Disinhibition (HP:0000734)2.70341931
64Facial diplegia (HP:0001349)2.70186831
65T lymphocytopenia (HP:0005403)2.67683682
66Myopathic facies (HP:0002058)2.66779347
67Pustule (HP:0200039)2.65956044
68Lip pit (HP:0100267)2.59991001
69Episodic fever (HP:0001954)2.59403521
70Supraventricular tachycardia (HP:0004755)2.58969601
71Supraventricular arrhythmia (HP:0005115)2.54651033
72Abnormality of T cell number (HP:0011839)2.47725128
73Cerebral aneurysm (HP:0004944)2.46139587
74Hip contracture (HP:0003273)2.46095709
75Popliteal pterygium (HP:0009756)2.45561223
76Vacuolated lymphocytes (HP:0001922)2.44584718
77Dysostosis multiplex (HP:0000943)2.44444644
78Loss of speech (HP:0002371)2.43702399
79Ventricular arrhythmia (HP:0004308)2.40760456
80Fatigable weakness (HP:0003473)2.39932416
81Abnormality of the neuromuscular junction (HP:0003398)2.39932416
82Encephalitis (HP:0002383)2.39451192
83Hematochezia (HP:0002573)2.39107855
84Pulmonary infiltrates (HP:0002113)2.38850991
85Lower limb amyotrophy (HP:0007210)2.37538070
86Leukocytosis (HP:0001974)2.35642432
87Chronic mucocutaneous candidiasis (HP:0002728)2.34789932
88Recurrent cutaneous fungal infections (HP:0011370)2.34789932
89Urethral obstruction (HP:0000796)2.32787486
90Osteomyelitis (HP:0002754)2.31903503
91Arterial thrombosis (HP:0004420)2.31896914
92Abnormal delayed hypersensitivity skin test (HP:0002963)2.31656436
93Hemoptysis (HP:0002105)2.30921603
94Autoimmune thrombocytopenia (HP:0001973)2.30331690
95Increased neuronal autofluorescent lipopigment (HP:0002074)2.29804943
96Palmoplantar keratoderma (HP:0000982)2.28976304
97Obstructive lung disease (HP:0006536)2.28907112
98Chronic obstructive pulmonary disease (HP:0006510)2.28907112
99Abnormality of skeletal muscle fiber size (HP:0012084)2.27637258
100Gastrointestinal infarctions (HP:0005244)2.27248798
101Gangrene (HP:0100758)2.25404035
102Urticaria (HP:0001025)2.25276089
103Panhypogammaglobulinemia (HP:0003139)2.25038282
104EMG: neuropathic changes (HP:0003445)2.24476172
105Increased serum ferritin (HP:0003281)2.22992141
106Abnormality of the ischium (HP:0003174)2.21537993
107Frequent falls (HP:0002359)2.20482998
108Hypoplastic ischia (HP:0003175)2.19970967
109Dilated cardiomyopathy (HP:0001644)2.19465948
110Gingivitis (HP:0000230)2.16990847
111Mutism (HP:0002300)2.16916101
112Neck muscle weakness (HP:0000467)2.15611622
113Bundle branch block (HP:0011710)2.14724292
114Polyneuropathy (HP:0001271)2.13872036
115Chest pain (HP:0100749)2.10875661
116Myocardial infarction (HP:0001658)2.08276810
117Cellulitis (HP:0100658)2.07934812
118Interstitial pulmonary disease (HP:0006530)2.07607365
119Palmoplantar hyperkeratosis (HP:0000972)2.06928577
120Scapular winging (HP:0003691)2.06405770
121Autoimmune hemolytic anemia (HP:0001890)2.04160300
122Myoglobinuria (HP:0002913)2.03891592
123Myotonia (HP:0002486)2.01608946
124Absent phalangeal crease (HP:0006109)2.01127528
125Sudden cardiac death (HP:0001645)2.00584903
126Abnormal atrioventricular conduction (HP:0005150)1.99059554
127Increased CSF protein (HP:0002922)1.99012041
128Aortic dissection (HP:0002647)1.98063272
129Vertigo (HP:0002321)1.96045412
130Limited hip movement (HP:0008800)1.94860714
131Achilles tendon contracture (HP:0001771)1.94681081
132Bicuspid aortic valve (HP:0001647)1.94439707
133Testicular atrophy (HP:0000029)1.94437265
134Restrictive lung disease (HP:0002091)1.94022268
135Increased variability in muscle fiber diameter (HP:0003557)1.93519956
136Fatigue (HP:0012378)1.92617258
137Abnormality of iron homeostasis (HP:0011031)1.92402398
138Atrioventricular block (HP:0001678)1.92073583
139Rhabdomyolysis (HP:0003201)1.91931764
140Palmar hyperkeratosis (HP:0010765)1.91049736
141Centrally nucleated skeletal muscle fibers (HP:0003687)1.88476562
142Glomerulonephritis (HP:0000099)1.88421286
143Sepsis (HP:0100806)1.88062322
144Slow saccadic eye movements (HP:0000514)1.86587952
145Calcaneovalgus deformity (HP:0001848)1.86410310
146Thick nail (HP:0001805)1.86174483
147Mildly elevated creatine phosphokinase (HP:0008180)1.85159377
148Gowers sign (HP:0003391)1.84677834
149Neuronal loss in central nervous system (HP:0002529)1.84454613
150Long clavicles (HP:0000890)1.83965013
151Abnormality of the endocardium (HP:0004306)1.83953454
152Colitis (HP:0002583)1.82337986
153Muscular dystrophy (HP:0003560)1.82269040
154Reduced subcutaneous adipose tissue (HP:0003758)1.81915471
155Aneurysm (HP:0002617)1.80839084
156Ventricular fibrillation (HP:0001663)1.80805147
157Fetal akinesia sequence (HP:0001989)1.80636272
158Malnutrition (HP:0004395)1.80230491
159Osteolytic defects of the hand bones (HP:0009699)1.79709732
160Osteolytic defects of the phalanges of the hand (HP:0009771)1.79709732
161Heart block (HP:0012722)1.79374979
162Agammaglobulinemia (HP:0004432)1.78726741
163Neoplasm of the tracheobronchial system (HP:0100552)1.77051237
164Pulmonary embolism (HP:0002204)1.76694637
165Plantar hyperkeratosis (HP:0007556)1.76490384
166Alveolar cell carcinoma (HP:0006519)1.76336410
167Mitral valve prolapse (HP:0001634)1.76239514
168Bulbar palsy (HP:0001283)1.75043490
169Abnormality of the Achilles tendon (HP:0005109)1.74168379
170Skin pits (HP:0100276)1.73685169
171Spinal rigidity (HP:0003306)1.71383446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR25.04372490
2OBSCN4.39945945
3IRAK33.09106505
4TTN2.92617232
5BLK2.76064394
6STK242.73320561
7PRPF4B2.68306595
8MAP3K32.63604739
9DMPK2.56756254
10RIPK42.49914405
11MAPK152.37519419
12IRAK42.32165277
13LATS12.11501866
14MAP3K132.06727085
15GRK72.03262276
16STK38L1.96030744
17STK101.91474300
18IKBKE1.89603352
19STK31.68330190
20MAPK121.63649681
21MUSK1.50937019
22IRAK11.49242933
23TAOK21.47477003
24MAPK71.46584552
25MAP2K31.45158020
26MAP3K71.45017566
27IRAK21.44917573
28MAPKAPK31.42749065
29CAMK1D1.39803414
30TAOK31.38048932
31ZAK1.37138751
32STK381.35393508
33PIK3CG1.34242411
34EPHA21.28867287
35MOS1.24914481
36MAP4K11.24192542
37FGFR41.23727719
38ITK1.23295312
39FGFR31.18461654
40CHUK1.17508920
41NEK91.17287009
42BTK1.15734028
43MST41.12834870
44SIK31.11491294
45FGR1.09459037
46TRPM71.08782916
47RIPK11.07552904
48JAK21.04800239
49FES1.04356552
50TNK21.04054550
51CDK61.03403674
52PHKG21.02689941
53PHKG11.02689941
54MATK1.01916450
55MAP3K61.00251958
56CDK120.97737659
57CAMK1G0.97533396
58JAK10.97393356
59MAP2K40.96684238
60MAP3K20.91905203
61MAP3K100.89809931
62NLK0.89584579
63RPS6KB20.88512877
64LATS20.87446052
65MAP3K50.87352468
66TIE10.85223664
67LYN0.84841493
68PINK10.84815838
69CSF1R0.81461770
70MST1R0.81445861
71MELK0.81183316
72LCK0.79409691
73PDK10.78863372
74TYK20.78451067
75PDK20.77284574
76IKBKB0.76234874
77KIT0.74653885
78PAK30.72733689
79CDC42BPA0.71932711
80RPS6KA40.71759097
81HCK0.70876213
82PDPK10.70860702
83TRIB30.70683765
84CDK30.69712584
85CSK0.69586273
86PDK30.68852884
87PDK40.68852884
88EPHB10.68524549
89BMPR20.67590623
90MAPK40.67346350
91RPS6KL10.65547958
92RPS6KC10.65547958
93PRKD10.62740597
94TXK0.62711266
95KSR20.61900487
96MARK20.60352626
97ALK0.59827341
98ZAP700.58838448
99ILK0.58508599
100CAMKK20.57418173
101MAP3K140.56494189
102PIM20.56145508
103MAPKAPK20.56061992
104SGK30.55831313
105YES10.55763667
106MAP3K90.55411553
107MARK30.54921705
108PLK20.53790309
109RPS6KA60.53722151
110GRK60.53584588
111PRKAA20.53329629
112MAPK110.52478953
113MAP2K10.51822925
114ABL10.50821775
115PKN20.50563184
116TAOK10.49767142
117SIK10.49384464
118JAK30.49282041
119DDR20.48906391
120MAP3K110.48179209
121RPS6KA10.47947088
122EPHA30.47651074
123SGK20.47527906
124RAF10.47329226
125LRRK20.47144652
126ERN10.46764670
127PIM10.45947644
128PDGFRB0.44982400
129SYK0.43859459
130FER0.43694984
131TYRO30.42732319
132CAMK40.42709781
133MAP3K10.40623144
134PIK3CA0.39229697
135HIPK20.39197042
136MAP2K20.39181987
137TEC0.39054094
138TBK10.38963154
139CDK40.37416407
140RPS6KA20.34356447

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.65121267
2NOD-like receptor signaling pathway_Homo sapiens_hsa046212.50991196
3Dilated cardiomyopathy_Homo sapiens_hsa054142.45438964
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.28535463
5Legionellosis_Homo sapiens_hsa051342.14708648
6B cell receptor signaling pathway_Homo sapiens_hsa046622.02840463
7Osteoclast differentiation_Homo sapiens_hsa043802.00583251
8Adherens junction_Homo sapiens_hsa045201.97804079
9Graft-versus-host disease_Homo sapiens_hsa053321.94161124
10Malaria_Homo sapiens_hsa051441.86962480
11Allograft rejection_Homo sapiens_hsa053301.84465219
12Rheumatoid arthritis_Homo sapiens_hsa053231.84271135
13Staphylococcus aureus infection_Homo sapiens_hsa051501.84040458
14Other glycan degradation_Homo sapiens_hsa005111.73385643
15Leishmaniasis_Homo sapiens_hsa051401.69011022
16Viral myocarditis_Homo sapiens_hsa054161.68360755
17Asthma_Homo sapiens_hsa053101.54803719
18Circadian rhythm_Homo sapiens_hsa047101.54315462
19Type I diabetes mellitus_Homo sapiens_hsa049401.53530906
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.52138511
21Oxytocin signaling pathway_Homo sapiens_hsa049211.50890355
22Autoimmune thyroid disease_Homo sapiens_hsa053201.50544153
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50199127
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.48914214
25VEGF signaling pathway_Homo sapiens_hsa043701.47140628
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42703695
27Pertussis_Homo sapiens_hsa051331.39401034
28Toxoplasmosis_Homo sapiens_hsa051451.32588068
29Insulin resistance_Homo sapiens_hsa049311.30513531
30Platelet activation_Homo sapiens_hsa046111.23561089
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23308207
32Lysosome_Homo sapiens_hsa041421.22249952
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.21979167
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.19893760
35Dorso-ventral axis formation_Homo sapiens_hsa043201.19638626
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19236554
37FoxO signaling pathway_Homo sapiens_hsa040681.19202284
38T cell receptor signaling pathway_Homo sapiens_hsa046601.16885849
39Focal adhesion_Homo sapiens_hsa045101.16731895
40African trypanosomiasis_Homo sapiens_hsa051431.16666499
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14847731
42Renal cell carcinoma_Homo sapiens_hsa052111.13766232
43GnRH signaling pathway_Homo sapiens_hsa049121.13760232
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12409132
45MAPK signaling pathway_Homo sapiens_hsa040101.11881342
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09487022
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08509995
48Pancreatic cancer_Homo sapiens_hsa052121.08282237
49Tuberculosis_Homo sapiens_hsa051521.06332105
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04952888
51Herpes simplex infection_Homo sapiens_hsa051681.04237350
52Tight junction_Homo sapiens_hsa045301.03585361
53Colorectal cancer_Homo sapiens_hsa052101.03161243
54Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02327734
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02306195
56Chronic myeloid leukemia_Homo sapiens_hsa052201.02272844
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01616724
58mTOR signaling pathway_Homo sapiens_hsa041501.00587486
59Proteoglycans in cancer_Homo sapiens_hsa052050.99686410
60Hepatitis B_Homo sapiens_hsa051610.98835783
61Phagosome_Homo sapiens_hsa041450.97862263
62Renin secretion_Homo sapiens_hsa049240.97452674
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.97391835
64Acute myeloid leukemia_Homo sapiens_hsa052210.96976757
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96042105
66Hepatitis C_Homo sapiens_hsa051600.95914343
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94931673
68HIF-1 signaling pathway_Homo sapiens_hsa040660.93768134
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91426573
70Salmonella infection_Homo sapiens_hsa051320.89389794
71Insulin signaling pathway_Homo sapiens_hsa049100.89167403
72Influenza A_Homo sapiens_hsa051640.87206615
73Antigen processing and presentation_Homo sapiens_hsa046120.86752176
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86589205
75Primary immunodeficiency_Homo sapiens_hsa053400.85594723
76Cardiac muscle contraction_Homo sapiens_hsa042600.85030920
77TNF signaling pathway_Homo sapiens_hsa046680.83261026
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83186466
79Caffeine metabolism_Homo sapiens_hsa002320.83048192
80Glucagon signaling pathway_Homo sapiens_hsa049220.81212445
81Rap1 signaling pathway_Homo sapiens_hsa040150.80498910
82Type II diabetes mellitus_Homo sapiens_hsa049300.79519435
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79495063
84Long-term potentiation_Homo sapiens_hsa047200.77723441
85ErbB signaling pathway_Homo sapiens_hsa040120.77285570
86MicroRNAs in cancer_Homo sapiens_hsa052060.77102099
87Estrogen signaling pathway_Homo sapiens_hsa049150.76685349
88Measles_Homo sapiens_hsa051620.75787061
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.75732524
90Glioma_Homo sapiens_hsa052140.73699053
91Calcium signaling pathway_Homo sapiens_hsa040200.73611613
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72338003
93HTLV-I infection_Homo sapiens_hsa051660.71295616
94TGF-beta signaling pathway_Homo sapiens_hsa043500.70823586
95Amoebiasis_Homo sapiens_hsa051460.70267133
96Small cell lung cancer_Homo sapiens_hsa052220.69689068
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67292539
98Non-small cell lung cancer_Homo sapiens_hsa052230.67178887
99Choline metabolism in cancer_Homo sapiens_hsa052310.66578760
100Apoptosis_Homo sapiens_hsa042100.66296871
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.65466695
102Shigellosis_Homo sapiens_hsa051310.65035592
103Prolactin signaling pathway_Homo sapiens_hsa049170.64326978
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64201127
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63666483
106Hippo signaling pathway_Homo sapiens_hsa043900.62258167
107Starch and sucrose metabolism_Homo sapiens_hsa005000.61700272
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.61092239
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61062426
110Olfactory transduction_Homo sapiens_hsa047400.59808486
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.59588583
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.58904614
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58599280
114Bladder cancer_Homo sapiens_hsa052190.57468069
115Chemokine signaling pathway_Homo sapiens_hsa040620.57456281
116Notch signaling pathway_Homo sapiens_hsa043300.56572355
117Ras signaling pathway_Homo sapiens_hsa040140.55766584
118Hematopoietic cell lineage_Homo sapiens_hsa046400.55394794
119Inositol phosphate metabolism_Homo sapiens_hsa005620.54414696
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.53831920
121Prion diseases_Homo sapiens_hsa050200.53559082
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53017987
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52765889
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52485220
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52394181
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51538646
127Prostate cancer_Homo sapiens_hsa052150.46603727
128Sphingolipid metabolism_Homo sapiens_hsa006000.46468821
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45062121
130Complement and coagulation cascades_Homo sapiens_hsa046100.43431026
131Epstein-Barr virus infection_Homo sapiens_hsa051690.39637877

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