OTUD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)6.77075148
2cell wall macromolecule catabolic process (GO:0016998)6.38522405
3cell wall macromolecule metabolic process (GO:0044036)6.38522405
4sperm-egg recognition (GO:0035036)6.02734629
5sperm motility (GO:0030317)5.94446656
6multicellular organism reproduction (GO:0032504)5.88030020
7binding of sperm to zona pellucida (GO:0007339)5.74231914
8detection of chemical stimulus involved in sensory perception of smell (GO:0050911)5.56905125
9cell-cell recognition (GO:0009988)5.53272584
10reproduction (GO:0000003)5.23653777
11piRNA metabolic process (GO:0034587)5.16951300
12synaptonemal complex assembly (GO:0007130)5.09446686
13acrosome assembly (GO:0001675)5.02940138
14plasma membrane fusion (GO:0045026)4.88336207
15synaptonemal complex organization (GO:0070193)4.84621315
16spermatid development (GO:0007286)4.74396683
17cilium or flagellum-dependent cell motility (GO:0001539)4.59455440
18motile cilium assembly (GO:0044458)4.57468282
19acrosome reaction (GO:0007340)4.56791258
20negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.53543542
21negative regulation of T-helper cell differentiation (GO:0045623)4.53543542
22righting reflex (GO:0060013)4.40534663
23attachment of spindle microtubules to kinetochore (GO:0008608)4.39609711
24monoubiquitinated protein deubiquitination (GO:0035520)4.37466653
25male meiosis (GO:0007140)4.35104552
26positive regulation of RNA splicing (GO:0033120)4.33129874
27axonemal dynein complex assembly (GO:0070286)4.08092976
28tooth mineralization (GO:0034505)3.96850954
29synapsis (GO:0007129)3.90634631
30nuclear pore complex assembly (GO:0051292)3.87907813
31chromosome condensation (GO:0030261)3.73943964
32positive regulation of protein sumoylation (GO:0033235)3.72423303
33nuclear pore organization (GO:0006999)3.70683525
34detection of chemical stimulus involved in sensory perception (GO:0050907)3.70223636
35negative regulation of alpha-beta T cell differentiation (GO:0046639)3.70103712
36negative regulation of DNA-dependent DNA replication (GO:2000104)3.62619192
37regulation of DNA endoreduplication (GO:0032875)3.60068583
38DNA replication-dependent nucleosome organization (GO:0034723)3.56957088
39DNA replication-dependent nucleosome assembly (GO:0006335)3.56957088
40chaperone-mediated protein complex assembly (GO:0051131)3.55843812
41neural tube formation (GO:0001841)3.53542390
42intestinal cholesterol absorption (GO:0030299)3.52920752
43epithelial cilium movement (GO:0003351)3.48917170
44DNA packaging (GO:0006323)3.45841519
45regulation of meiosis I (GO:0060631)3.43623878
46replication fork processing (GO:0031297)3.39035624
47DNA replication checkpoint (GO:0000076)3.37791399
48male meiosis I (GO:0007141)3.36377402
49negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.34098707
50heterochromatin organization (GO:0070828)3.32048380
51negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.31822403
52negative regulation of translation, ncRNA-mediated (GO:0040033)3.31822403
53regulation of translation, ncRNA-mediated (GO:0045974)3.31822403
54dendritic spine morphogenesis (GO:0060997)3.31676850
55regulation of translational termination (GO:0006449)3.31536014
56gene silencing by RNA (GO:0031047)3.30577233
57single fertilization (GO:0007338)3.30484034
58spermatogenesis (GO:0007283)3.28435454
59male gamete generation (GO:0048232)3.27494400
60regulation of hippo signaling (GO:0035330)3.26891668
61negative regulation of inclusion body assembly (GO:0090084)3.20281814
624-hydroxyproline metabolic process (GO:0019471)3.19825868
63cellular response to arsenic-containing substance (GO:0071243)3.17099797
64microtubule anchoring (GO:0034453)3.16765652
65DNA methylation involved in gamete generation (GO:0043046)3.15941274
66sister chromatid cohesion (GO:0007062)3.15276155
67amino-acid betaine transport (GO:0015838)3.14866893
68carnitine transport (GO:0015879)3.14866893
69negative regulation of cytosolic calcium ion concentration (GO:0051481)3.13252665
70carnitine transmembrane transport (GO:1902603)3.12274291
71fertilization (GO:0009566)3.10158631
72regulation of inclusion body assembly (GO:0090083)3.04835082
73meiotic nuclear division (GO:0007126)3.02367585
74maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02341105
75gamete generation (GO:0007276)3.02075543
76ncRNA catabolic process (GO:0034661)3.00969928
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98849120
78interferon-gamma secretion (GO:0072643)2.98528405
79sexual reproduction (GO:0019953)2.98336928
80regulation of DNA methylation (GO:0044030)2.97286097
81chromosome organization involved in meiosis (GO:0070192)2.96913586
82gene silencing (GO:0016458)2.96892128
83peptidyl-proline hydroxylation (GO:0019511)2.96715409
84seminiferous tubule development (GO:0072520)2.95484887
85epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95006398
86regulation of centriole replication (GO:0046599)2.94730797
87negative regulation of cell size (GO:0045792)2.92426329
88retina layer formation (GO:0010842)2.92397075
89cellular process involved in reproduction in multicellular organism (GO:0022412)2.92309632
90positive regulation of histone H3-K4 methylation (GO:0051571)2.91495370
91regulation of chromatin binding (GO:0035561)2.89490248
92nephron tubule morphogenesis (GO:0072078)2.88643438
93nephron epithelium morphogenesis (GO:0072088)2.88643438
94mitotic sister chromatid cohesion (GO:0007064)2.88090796
95regulation of RNA export from nucleus (GO:0046831)2.87649641
96activation of protein kinase A activity (GO:0034199)2.86300928
97meiosis I (GO:0007127)2.86016850
98somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85750875
99somatic hypermutation of immunoglobulin genes (GO:0016446)2.85750875
100regulation of cilium movement (GO:0003352)2.85083006
101protein hydroxylation (GO:0018126)2.84908204
102chemosensory behavior (GO:0007635)2.84840899
103protein localization to chromosome, centromeric region (GO:0071459)2.84666225
104centriole replication (GO:0007099)2.84435706
105retinal cone cell development (GO:0046549)2.83882445
106germ cell development (GO:0007281)2.81921395
107organic cation transport (GO:0015695)2.81818035
108NLS-bearing protein import into nucleus (GO:0006607)2.81106723
109nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80053874
110enteric nervous system development (GO:0048484)2.79127160
111regulation of acrosome reaction (GO:0060046)2.78547592
112sperm capacitation (GO:0048240)2.77763491
113regulation of T-helper 1 cell differentiation (GO:0045625)2.77267852
114regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74406476
115regulation of mitotic spindle checkpoint (GO:1903504)2.74406476
116chromatin remodeling at centromere (GO:0031055)2.74173948
117carnitine shuttle (GO:0006853)2.73918814
118reflex (GO:0060004)2.73747485
119urea cycle (GO:0000050)2.73550474
120urea metabolic process (GO:0019627)2.73550474
121double-strand break repair via homologous recombination (GO:0000724)2.70582997
122meiotic cell cycle (GO:0051321)2.70368912
123low-density lipoprotein particle clearance (GO:0034383)2.70329342
124recombinational repair (GO:0000725)2.68806547
125pore complex assembly (GO:0046931)2.67873860
126glycine metabolic process (GO:0006544)2.67470063
127* protein K11-linked deubiquitination (GO:0035871)2.67430152
128histone exchange (GO:0043486)2.65965104
129anterior/posterior axis specification, embryo (GO:0008595)2.65511069
130response to pheromone (GO:0019236)2.63823537
131positive regulation of mitochondrial fission (GO:0090141)2.62404826
132fatty acid transmembrane transport (GO:1902001)2.62231479
133hemidesmosome assembly (GO:0031581)2.60984403
134phosphatidylinositol acyl-chain remodeling (GO:0036149)2.60608870
135metaphase plate congression (GO:0051310)2.59043804
136protein K6-linked ubiquitination (GO:0085020)2.58960261
137mitotic metaphase plate congression (GO:0007080)2.58901623
138intestinal absorption (GO:0050892)2.58218774
139CENP-A containing nucleosome assembly (GO:0034080)2.57940040
140embryonic digestive tract morphogenesis (GO:0048557)2.57206003
141detection of chemical stimulus (GO:0009593)2.56858660
142cysteine metabolic process (GO:0006534)2.56136466
143regulation of sister chromatid segregation (GO:0033045)2.54571496
144regulation of mitotic sister chromatid separation (GO:0010965)2.54571496
145regulation of mitotic sister chromatid segregation (GO:0033047)2.54571496
146regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.54515110
147response to arsenic-containing substance (GO:0046685)2.54320635
148cell adhesion mediated by integrin (GO:0033627)2.54253764
149mitotic nuclear envelope disassembly (GO:0007077)2.53498411
150cilium movement (GO:0003341)2.52397112
151spindle checkpoint (GO:0031577)2.52395243
152fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.51295581
153regulation of protein sumoylation (GO:0033233)2.50845569
154intestinal epithelial cell development (GO:0060576)2.50191604
155regulation of centrosome cycle (GO:0046605)2.49542406
156regulation of protein polyubiquitination (GO:1902914)2.49233012
157resolution of meiotic recombination intermediates (GO:0000712)2.48455961
158phosphatidylserine acyl-chain remodeling (GO:0036150)2.48278906
159protein prenylation (GO:0018342)2.47629461
160prenylation (GO:0097354)2.47629461
161DNA double-strand break processing (GO:0000729)2.47404518
162chromatin silencing (GO:0006342)2.47118220
163mRNA stabilization (GO:0048255)2.46991972
164RNA stabilization (GO:0043489)2.46991972
165serine family amino acid catabolic process (GO:0009071)2.46975334
166renal system development (GO:0072001)2.46618057
167regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.45965393
168regulation of mitotic metaphase/anaphase transition (GO:0030071)2.45965393
169mitotic spindle checkpoint (GO:0071174)2.45917290
170regulation of fatty acid beta-oxidation (GO:0031998)2.45829947
171histone H2A acetylation (GO:0043968)2.45619953
172cAMP biosynthetic process (GO:0006171)2.43891941
173regulation of nuclear cell cycle DNA replication (GO:0033262)2.43458299
174left/right axis specification (GO:0070986)2.43356017
175microtubule depolymerization (GO:0007019)2.43322939
176negative regulation of astrocyte differentiation (GO:0048712)2.43158961
177positive regulation of mitotic sister chromatid separation (GO:1901970)2.42919600
178positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.42919600
179positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.42919600
180regulation of nucleobase-containing compound transport (GO:0032239)2.42831393
181membrane disassembly (GO:0030397)2.42502445
182nuclear envelope disassembly (GO:0051081)2.42502445
183pre-miRNA processing (GO:0031054)2.42368531
184protein deneddylation (GO:0000338)2.42343122
185positive regulation of chromosome segregation (GO:0051984)2.42108841
186multicellular organismal reproductive process (GO:0048609)2.41791789
187somite rostral/caudal axis specification (GO:0032525)2.41372789

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.50537324
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.08995594
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.66948498
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.24412995
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.18007241
6VDR_22108803_ChIP-Seq_LS180_Human3.14317822
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.04938537
8ZNF274_21170338_ChIP-Seq_K562_Hela2.88774367
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.72690870
10IGF1R_20145208_ChIP-Seq_DFB_Human2.70152516
11GBX2_23144817_ChIP-Seq_PC3_Human2.65326777
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52800897
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.47346807
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.43387001
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.41485497
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.37668934
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34134041
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.32697312
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32394980
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27792832
21FUS_26573619_Chip-Seq_HEK293_Human2.27408730
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25655042
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.23656752
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18791449
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11775838
26EWS_26573619_Chip-Seq_HEK293_Human2.06823194
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.04366930
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02205657
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98244307
30MYC_22102868_ChIP-Seq_BL_Human1.94893164
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93912176
32E2F7_22180533_ChIP-Seq_HELA_Human1.92307824
33* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.92245316
34EZH2_22144423_ChIP-Seq_EOC_Human1.87581006
35AR_21572438_ChIP-Seq_LNCaP_Human1.84852488
36P300_19829295_ChIP-Seq_ESCs_Human1.79504549
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78154147
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.77638336
39TCF7_22412390_ChIP-Seq_EML_Mouse1.75342130
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.75154849
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74657080
42AR_21909140_ChIP-Seq_LNCAP_Human1.73217374
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69788877
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66891936
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66670714
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.65996941
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63954465
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63484490
49ZNF263_19887448_ChIP-Seq_K562_Human1.61629615
50SMAD4_21799915_ChIP-Seq_A2780_Human1.60159090
51ATF3_27146783_Chip-Seq_COLON_Human1.57244915
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.57182703
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56733036
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56293774
55* STAT3_23295773_ChIP-Seq_U87_Human1.55910794
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.54892871
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54760902
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54760902
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54562815
60ER_23166858_ChIP-Seq_MCF-7_Human1.50870914
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50379487
62CBP_20019798_ChIP-Seq_JUKART_Human1.50368712
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50368712
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47755863
65* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44303723
66TP53_16413492_ChIP-PET_HCT116_Human1.44266976
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44208072
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.42899646
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.42144188
70* KDM2B_26808549_Chip-Seq_DND41_Human1.41252229
71TAF15_26573619_Chip-Seq_HEK293_Human1.40395809
72BCAT_22108803_ChIP-Seq_LS180_Human1.40253644
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39344735
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37393762
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.36374088
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35829167
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35804166
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35475385
79FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34185178
80GATA6_25053715_ChIP-Seq_YYC3_Human1.33614696
81* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33281171
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32380118
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.30005702
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.29513472
85RNF2_27304074_Chip-Seq_NSC_Mouse1.29512231
86TCF4_23295773_ChIP-Seq_U87_Human1.29432773
87* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28722530
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27531139
89AR_25329375_ChIP-Seq_VCAP_Human1.27401167
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26839873
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26415078
92FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26170842
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25987988
94NCOR1_26117541_ChIP-Seq_K562_Human1.25495276
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25117520
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24814495
97NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23484668
98ELK1_19687146_ChIP-ChIP_HELA_Human1.23189387
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21752043
100CLOCK_20551151_ChIP-Seq_293T_Human1.19979738
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.19791697
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.19456766
103TCF4_22108803_ChIP-Seq_LS180_Human1.17916956
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17115705
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16556708
106GATA1_26923725_Chip-Seq_HPCs_Mouse1.16310567
107* RACK7_27058665_Chip-Seq_MCF-7_Human1.15883763
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15760024
109ELK4_26923725_Chip-Seq_MESODERM_Mouse1.15482002
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15133878
111RUNX1_27514584_Chip-Seq_MCF-7_Human1.15037564
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15029695
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14650380
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14611935
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14429717
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.12883540
117SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12450869
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.11937237
119P53_22387025_ChIP-Seq_ESCs_Mouse1.10525438
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10292465
121SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09493388
122TBX20_22328084_ChIP-Seq_HEART_Mouse1.09403947
123TBX20_22080862_ChIP-Seq_HEART_Mouse1.09403947
124RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09037264
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08983861
126SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08920761
127P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08524947
128TP63_19390658_ChIP-ChIP_HaCaT_Human1.08468672
129PRDM14_20953172_ChIP-Seq_ESCs_Human1.08373801
130GATA4_25053715_ChIP-Seq_YYC3_Human1.07854438
131CMYC_18555785_Chip-Seq_ESCs_Mouse1.07608142
132FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07462203
133* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07433633
134E2F1_21310950_ChIP-Seq_MCF-7_Human1.06485861
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06375753
136MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05240095
137HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04947638
138NOTCH1_21737748_ChIP-Seq_TLL_Human1.04598923
139ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04428386
140SOX2_18555785_Chip-Seq_ESCs_Mouse1.04116353
141VDR_21846776_ChIP-Seq_THP-1_Human1.04104682
142MYC_18940864_ChIP-ChIP_HL60_Human1.04054426
143POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03726505
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03600895
145* CDX2_22108803_ChIP-Seq_LS180_Human1.03163966
146RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02815076
147SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02586648
148BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01617239
149CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01231337
150RARA_24833708_ChIP-Seq_LIVER_Mouse1.00563814
151FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00266713
152PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00051091
153CRX_20693478_ChIP-Seq_RETINA_Mouse0.99786811
154UTX_26944678_Chip-Seq_JUKART_Human0.99674285
155MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98305837
156* TBL1_22424771_ChIP-Seq_293T_Human0.98207352
157SMAD3_21741376_ChIP-Seq_HESCs_Human0.98038056
158STAT3_18555785_Chip-Seq_ESCs_Mouse0.97889137
159LXR_22292898_ChIP-Seq_THP-1_Human0.97631845
160FLI1_21867929_ChIP-Seq_TH2_Mouse0.97316375
161BCOR_27268052_Chip-Seq_Bcells_Human0.97092223
162IRF1_19129219_ChIP-ChIP_H3396_Human0.97071160
163HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96939212
164MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96874115
165E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96726662
166* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96642329
167P68_20966046_ChIP-Seq_HELA_Human0.95866770
168CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95061688
169NANOG_19829295_ChIP-Seq_ESCs_Human0.94841311
170SOX2_19829295_ChIP-Seq_ESCs_Human0.94841311
171NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94581793
172TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94395716
173FOXA2_19822575_ChIP-Seq_HepG2_Human0.94065315
174SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92918118
175NANOG_21062744_ChIP-ChIP_HESCs_Human0.91417948
176SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91245662
177TP53_22127205_ChIP-Seq_IMR90_Human0.91173791
178SPI1_20517297_ChIP-Seq_HL60_Human0.90979144
179CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90908711
180PHF8_20622854_ChIP-Seq_HELA_Human0.90597889
181NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90451602
182NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90257455
183RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90250318
184ELF1_20517297_ChIP-Seq_JURKAT_Human0.90151898
185STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89222953
186KDM5A_27292631_Chip-Seq_BREAST_Human0.88942837
187MYB_26560356_Chip-Seq_TH1_Human0.88935433
188KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88598516
189ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87926149
190PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87586602
191PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87208582
192FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85233243
193MAF_26560356_Chip-Seq_TH1_Human0.85161242
194UBF1/2_26484160_Chip-Seq_HMECs_Human0.84639777
195NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84321756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.86874542
2MP0005084_abnormal_gallbladder_morpholo4.13676184
3MP0003705_abnormal_hypodermis_morpholog3.90528694
4MP0003718_maternal_effect3.49936536
5MP0005365_abnormal_bile_salt3.02454798
6MP0008057_abnormal_DNA_replication2.98589659
7MP0000372_irregular_coat_pigmentation2.59609010
8MP0006292_abnormal_olfactory_placode2.58913082
9MP0010352_gastrointestinal_tract_polyps2.50635275
10MP0010234_abnormal_vibrissa_follicle2.50184945
11MP0008058_abnormal_DNA_repair2.50140498
12MP0005360_urolithiasis2.43464171
13MP0003890_abnormal_embryonic-extraembry2.29345942
14MP0002139_abnormal_hepatobiliary_system2.28214714
15MP0005083_abnormal_biliary_tract2.26359299
16MP0001666_abnormal_nutrient_absorption2.25488894
17MP0005085_abnormal_gallbladder_physiolo2.23363464
18MP0002102_abnormal_ear_morphology2.21687214
19MP0005076_abnormal_cell_differentiation2.16191467
20MP0001929_abnormal_gametogenesis2.14533401
21MP0006072_abnormal_retinal_apoptosis2.14111377
22MP0010307_abnormal_tumor_latency2.09360141
23MP0004185_abnormal_adipocyte_glucose2.03252581
24MP0009840_abnormal_foam_cell1.98537106
25MP0001849_ear_inflammation1.92073609
26MP0003698_abnormal_male_reproductive1.91178628
27MP0002938_white_spotting1.84612635
28MP0003121_genomic_imprinting1.74675571
29MP0005670_abnormal_white_adipose1.72603303
30MP0003252_abnormal_bile_duct1.72172456
31MP0003646_muscle_fatigue1.67021187
32MP0003787_abnormal_imprinting1.66386870
33MP0005551_abnormal_eye_electrophysiolog1.65006995
34MP0005451_abnormal_body_composition1.63429157
35MP0005646_abnormal_pituitary_gland1.62475700
36MP0001293_anophthalmia1.59682180
37MP0003195_calcinosis1.57594794
38MP0005666_abnormal_adipose_tissue1.57082042
39MP0008877_abnormal_DNA_methylation1.56177496
40MP0003693_abnormal_embryo_hatching1.55300124
41MP0009780_abnormal_chondrocyte_physiolo1.52635551
42MP0005253_abnormal_eye_physiology1.52276980
43MP0004133_heterotaxia1.52092739
44MP0000631_abnormal_neuroendocrine_gland1.51894986
45MP0005623_abnormal_meninges_morphology1.50805206
46MP0001730_embryonic_growth_arrest1.46498597
47MP0003111_abnormal_nucleus_morphology1.46072954
48MP0002269_muscular_atrophy1.45061085
49MP0002210_abnormal_sex_determination1.41273107
50MP0004233_abnormal_muscle_weight1.40902517
51MP0003136_yellow_coat_color1.40862514
52MP0005408_hypopigmentation1.40206792
53MP0010329_abnormal_lipoprotein_level1.38747691
54MP0002751_abnormal_autonomic_nervous1.36553763
55MP0000569_abnormal_digit_pigmentation1.36506119
56MP0002234_abnormal_pharynx_morphology1.33941313
57MP0005395_other_phenotype1.29978106
58MP0005257_abnormal_intraocular_pressure1.29847292
59MP0004264_abnormal_extraembryonic_tissu1.29031416
60MP0008789_abnormal_olfactory_epithelium1.25905071
61MP0003943_abnormal_hepatobiliary_system1.24471327
62MP0003221_abnormal_cardiomyocyte_apopto1.23971460
63MP0000750_abnormal_muscle_regeneration1.23639510
64MP0002161_abnormal_fertility/fecundity1.22511979
65MP0003300_gastrointestinal_ulcer1.22432773
66MP0002160_abnormal_reproductive_system1.21443809
67MP0001145_abnormal_male_reproductive1.20618978
68MP0000609_abnormal_liver_physiology1.20033269
69MP0000427_abnormal_hair_cycle1.18783059
70MP0003806_abnormal_nucleotide_metabolis1.17544919
71MP0003303_peritoneal_inflammation1.16502562
72MP0005645_abnormal_hypothalamus_physiol1.16189984
73MP0003566_abnormal_cell_adhesion1.15489927
74MP0002653_abnormal_ependyma_morphology1.14081317
75MP0004087_abnormal_muscle_fiber1.12970405
76MP0002233_abnormal_nose_morphology1.12851947
77MP0008995_early_reproductive_senescence1.12845919
78MP0003984_embryonic_growth_retardation1.12147023
79MP0003786_premature_aging1.11900629
80MP0005379_endocrine/exocrine_gland_phen1.11074776
81MP0008438_abnormal_cutaneous_collagen1.09567458
82MP0000733_abnormal_muscle_development1.09424080
83MP0002088_abnormal_embryonic_growth/wei1.08802137
84MP0001944_abnormal_pancreas_morphology1.08554345
85MP0005023_abnormal_wound_healing1.08327567
86MP0005380_embryogenesis_phenotype1.08180909
87MP0001672_abnormal_embryogenesis/_devel1.08180909
88MP0005174_abnormal_tail_pigmentation1.07414360
89MP0003937_abnormal_limbs/digits/tail_de1.07372833
90MP0003567_abnormal_fetal_cardiomyocyte1.06457560
91MP0000350_abnormal_cell_proliferation1.05458639
92MP0005220_abnormal_exocrine_pancreas1.05223497
93MP0010630_abnormal_cardiac_muscle1.04304338
94MP0000653_abnormal_sex_gland1.03914329
95MP0005375_adipose_tissue_phenotype1.03802345
96MP0004130_abnormal_muscle_cell1.03427284
97MP0003077_abnormal_cell_cycle1.02665932
98MP0005394_taste/olfaction_phenotype1.02485583
99MP0005499_abnormal_olfactory_system1.02485583
100MP0008961_abnormal_basal_metabolism1.02273996
101MP0001485_abnormal_pinna_reflex1.02237156
102MP0004957_abnormal_blastocyst_morpholog1.01382752
103MP0002086_abnormal_extraembryonic_tissu1.01158336
104MP0001529_abnormal_vocalization1.00415983
105MP0004272_abnormal_basement_membrane1.00250498
106MP0001984_abnormal_olfaction0.99472994
107MP0003868_abnormal_feces_composition0.99368940
108MP0000516_abnormal_urinary_system0.98839917
109MP0005367_renal/urinary_system_phenotyp0.98839917
110MP0008932_abnormal_embryonic_tissue0.97984958
111MP0003950_abnormal_plasma_membrane0.97178620
112MP0009046_muscle_twitch0.96485537
113MP0001697_abnormal_embryo_size0.96199954
114MP0008875_abnormal_xenobiotic_pharmacok0.95631715
115MP0002638_abnormal_pupillary_reflex0.95355760
116MP0003119_abnormal_digestive_system0.94755001
117MP0002396_abnormal_hematopoietic_system0.94335358
118MP0002909_abnormal_adrenal_gland0.92953537
119MP0002084_abnormal_developmental_patter0.92828055
120MP0002118_abnormal_lipid_homeostasis0.91688030
121MP0003115_abnormal_respiratory_system0.91343675
122MP0005319_abnormal_enzyme/_coenzyme0.91219078
123MP0004043_abnormal_pH_regulation0.91005086
124MP0004197_abnormal_fetal_growth/weight/0.90305852
125MP0001270_distended_abdomen0.90076903
126MP0005391_vision/eye_phenotype0.89591003
127MP0003123_paternal_imprinting0.88644588
128MP0010094_abnormal_chromosome_stability0.87673659
129MP0001915_intracranial_hemorrhage0.86612906
130MP0001119_abnormal_female_reproductive0.86370926
131MP0003699_abnormal_female_reproductive0.85870349
132MP0004808_abnormal_hematopoietic_stem0.85738763
133MP0009703_decreased_birth_body0.85722628
134MP0004084_abnormal_cardiac_muscle0.85652076
135MP0002877_abnormal_melanocyte_morpholog0.85033285
136MP0001299_abnormal_eye_distance/0.84272465
137MP0003122_maternal_imprinting0.83364642
138MP0005389_reproductive_system_phenotype0.81786785
139MP0003755_abnormal_palate_morphology0.81018965
140MP0000598_abnormal_liver_morphology0.80062219
141MP0002163_abnormal_gland_morphology0.80030956
142MP0002080_prenatal_lethality0.79832304
143MP0001986_abnormal_taste_sensitivity0.79790025
144MP0005397_hematopoietic_system_phenotyp0.78921876
145MP0001545_abnormal_hematopoietic_system0.78921876
146MP0003091_abnormal_cell_migration0.77147123
147MP0008872_abnormal_physiological_respon0.77085734
148MP0005075_abnormal_melanosome_morpholog0.76696974
149MP0008007_abnormal_cellular_replicative0.76606977
150MP0009278_abnormal_bone_marrow0.76306725
151MP0004142_abnormal_muscle_tone0.75987033
152MP0003191_abnormal_cellular_cholesterol0.75768834
153MP0002138_abnormal_hepatobiliary_system0.75163087
154MP0002085_abnormal_embryonic_tissue0.74499026
155MP0002572_abnormal_emotion/affect_behav0.73259727
156MP0000747_muscle_weakness0.72948422
157MP0002272_abnormal_nervous_system0.72881391
158MP0002557_abnormal_social/conspecific_i0.72810704
159MP0000015_abnormal_ear_pigmentation0.71836878
160MP0004270_analgesia0.71280207
161MP0000751_myopathy0.71205841
162MP0010678_abnormal_skin_adnexa0.70464873
163MP0005332_abnormal_amino_acid0.70070466
164MP0003828_pulmonary_edema0.70065610
165MP0002971_abnormal_brown_adipose0.69618696
166MP0002928_abnormal_bile_duct0.68889342
167MP0003436_decreased_susceptibility_to0.68351706
168MP0005330_cardiomyopathy0.68211692
169MP0003453_abnormal_keratinocyte_physiol0.68084371
170MP0000858_altered_metastatic_potential0.67394502
171MP0000003_abnormal_adipose_tissue0.66565639
172MP0009115_abnormal_fat_cell0.65898206
173MP0002837_dystrophic_cardiac_calcinosis0.65434499
174MP0002060_abnormal_skin_morphology0.64565035
175MP0006054_spinal_hemorrhage0.63842894

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.66133178
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.39502146
3Absent/shortened dynein arms (HP:0200106)5.39502146
4Nasal polyposis (HP:0100582)4.31147253
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.23711065
6Chromsome breakage (HP:0040012)4.00721266
7Volvulus (HP:0002580)3.83851708
8Abnormality of the nasal mucosa (HP:0000433)3.65348276
9Infertility (HP:0000789)3.55052362
10Abnormality of midbrain morphology (HP:0002418)3.50292149
11Molar tooth sign on MRI (HP:0002419)3.50292149
12Chronic bronchitis (HP:0004469)3.42886374
13Abnormal respiratory motile cilium physiology (HP:0012261)3.41429453
14Male infertility (HP:0003251)3.41314921
15Aplasia/Hypoplasia of the uvula (HP:0010293)3.39922765
16Difficulty climbing stairs (HP:0003551)3.32244219
17Abnormality of chromosome stability (HP:0003220)3.26984349
18Abnormal respiratory motile cilium morphology (HP:0005938)3.24982879
19Abnormal respiratory epithelium morphology (HP:0012253)3.24982879
20Rhinitis (HP:0012384)3.13940158
21Meckel diverticulum (HP:0002245)3.12747918
22Abnormality of the ileum (HP:0001549)3.07562213
23Ectopic kidney (HP:0000086)3.07045413
24Increased connective tissue (HP:0009025)2.98414788
25Abnormality of the labia minora (HP:0012880)2.93180746
26Myocardial infarction (HP:0001658)2.92525509
27Ependymoma (HP:0002888)2.88078423
28Abnormality of the preputium (HP:0100587)2.86544327
29Intestinal atresia (HP:0011100)2.86475563
30Exercise-induced muscle cramps (HP:0003710)2.79605548
31Polyuria (HP:0000103)2.76667720
32Overgrowth (HP:0001548)2.74514234
33Osteomalacia (HP:0002749)2.67453895
34Bundle branch block (HP:0011710)2.67060221
35Hyporeflexia of lower limbs (HP:0002600)2.65169276
36Abnormality of calcium-phosphate metabolism (HP:0100530)2.60663995
37Deep venous thrombosis (HP:0002625)2.58869714
38Abnormality of endocrine pancreas physiology (HP:0012093)2.56377484
39Abnormality of the pancreatic islet cells (HP:0006476)2.56377484
40Gaze-evoked nystagmus (HP:0000640)2.53307444
41Pancreatic cysts (HP:0001737)2.52525686
42Nephronophthisis (HP:0000090)2.50531807
43Global brain atrophy (HP:0002283)2.50414645
44Polycythemia (HP:0001901)2.47833321
45Asymmetric septal hypertrophy (HP:0001670)2.45759335
46Impulsivity (HP:0100710)2.43033443
47Abnormality of the astrocytes (HP:0100707)2.42549031
48Astrocytoma (HP:0009592)2.42549031
49Abnormality of the lower motor neuron (HP:0002366)2.42423466
50Small intestinal stenosis (HP:0012848)2.40765804
51Duodenal stenosis (HP:0100867)2.40765804
52Amelogenesis imperfecta (HP:0000705)2.37342958
53Rhabdomyolysis (HP:0003201)2.35846268
54Clubbing of toes (HP:0100760)2.34478267
55Abnormality of monocarboxylic acid metabolism (HP:0010996)2.33392601
56Muscle fiber splitting (HP:0003555)2.32239917
57Abnormality of the duodenum (HP:0002246)2.31519594
58Ulnar deviation of the wrist (HP:0003049)2.30481027
59Glioma (HP:0009733)2.27763073
60Cerebral aneurysm (HP:0004944)2.27132825
61Hemorrhage of the eye (HP:0011885)2.27072474
62Myoglobinuria (HP:0002913)2.26993165
63Supernumerary spleens (HP:0009799)2.26481255
64Pancreatic fibrosis (HP:0100732)2.25604338
65Genu recurvatum (HP:0002816)2.24769767
66Xanthomatosis (HP:0000991)2.23188871
67Sloping forehead (HP:0000340)2.23172512
68Oligodactyly (hands) (HP:0001180)2.22823124
69Small hand (HP:0200055)2.22589009
70Milia (HP:0001056)2.21995971
71Abnormality of the renal cortex (HP:0011035)2.21927830
72Neoplasm of the adrenal cortex (HP:0100641)2.19468031
73Hypoplastic pelvis (HP:0008839)2.19073099
74Aplasia/Hypoplasia of the fovea (HP:0008060)2.18360478
75Hypoplasia of the fovea (HP:0007750)2.18360478
76Hematochezia (HP:0002573)2.16938437
77Abnormality of the renal medulla (HP:0100957)2.15812037
78Hypoalphalipoproteinemia (HP:0003233)2.15722152
79Abnormal lung lobation (HP:0002101)2.15341445
80Bifid tongue (HP:0010297)2.13654277
81Nephroblastoma (Wilms tumor) (HP:0002667)2.12196537
82Abnormality of glutamine family amino acid metabolism (HP:0010902)2.11674478
83Wrist flexion contracture (HP:0001239)2.11617150
84Progressive inability to walk (HP:0002505)2.11253951
85Difficulty running (HP:0009046)2.10782772
86Drooling (HP:0002307)2.09799466
87Abnormality of dental color (HP:0011073)2.09507201
88Rectal prolapse (HP:0002035)2.08773626
89Abnormal urine output (HP:0012590)2.08319600
90Congenital sensorineural hearing impairment (HP:0008527)2.07902851
91Chronic hepatic failure (HP:0100626)2.07697881
92Abdominal situs inversus (HP:0003363)2.06963752
93Abnormality of abdominal situs (HP:0011620)2.06963752
94Gout (HP:0001997)2.06228740
95Right ventricular cardiomyopathy (HP:0011663)2.05460152
96Birth length less than 3rd percentile (HP:0003561)2.04733303
97Protrusio acetabuli (HP:0003179)2.04528085
98Lip pit (HP:0100267)2.04340369
99Abnormality of the carotid arteries (HP:0005344)2.04166129
100Round ear (HP:0100830)2.03036994
101Septo-optic dysplasia (HP:0100842)2.02146276
102Ketoacidosis (HP:0001993)2.02066799
103Exercise-induced myalgia (HP:0003738)2.01567388
104Embryonal renal neoplasm (HP:0011794)2.01218908
105Heterotopia (HP:0002282)2.00380522
106Hydroxyprolinuria (HP:0003080)1.98120124
107Abnormality of proline metabolism (HP:0010907)1.98120124
108Gastrointestinal atresia (HP:0002589)1.98065972
109Bronchitis (HP:0012387)1.97081739
110Hypercholesterolemia (HP:0003124)1.96768806
111Esophageal varix (HP:0002040)1.96117834
112Hand muscle atrophy (HP:0009130)1.95449670
113Abnormality of the Achilles tendon (HP:0005109)1.95409623
114Cervical subluxation (HP:0003308)1.90800699
115Tubular atrophy (HP:0000092)1.90708936
116Abnormal ciliary motility (HP:0012262)1.89865300
117Mitral stenosis (HP:0001718)1.89722555
118Hyperacusis (HP:0010780)1.89389290
119Hypolipoproteinemia (HP:0010981)1.89271019
120Distal upper limb amyotrophy (HP:0007149)1.88878753
121Upper limb amyotrophy (HP:0009129)1.88878753
122Hyperglycemia (HP:0003074)1.88650287
123Malnutrition (HP:0004395)1.87260391
124Hamartoma of the eye (HP:0010568)1.86819369
125Abnormality of renal resorption (HP:0011038)1.86743682
126True hermaphroditism (HP:0010459)1.86575532
127Achilles tendon contracture (HP:0001771)1.86458172
128Hypoplastic labia majora (HP:0000059)1.85905203
129Bronchiectasis (HP:0002110)1.85067644
130Hyperglycinuria (HP:0003108)1.83358998
131Arterial thrombosis (HP:0004420)1.82945800
132Inability to walk (HP:0002540)1.82738408
133Excessive salivation (HP:0003781)1.82223455
134Hyperinsulinemic hypoglycemia (HP:0000825)1.82155440
135Abnormality of DNA repair (HP:0003254)1.81801082
136Cortical dysplasia (HP:0002539)1.81151496
137Recurrent otitis media (HP:0000403)1.80493754
138Tachypnea (HP:0002789)1.79184865
139Cutaneous melanoma (HP:0012056)1.79128954
140Abnormality of the fovea (HP:0000493)1.79126801
141Highly arched eyebrow (HP:0002553)1.79053355
142Abnormality of the metopic suture (HP:0005556)1.78831368
143Ulnar bowing (HP:0003031)1.78050597
144EMG: neuropathic changes (HP:0003445)1.77974800
145Renovascular hypertension (HP:0100817)1.77279868
146Carpal bone hypoplasia (HP:0001498)1.77173738
147Abnormality of the renal collecting system (HP:0004742)1.76927587
148Upper motor neuron abnormality (HP:0002127)1.76313990
149Alopecia of scalp (HP:0002293)1.76039732
150Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76011246
151Subcapsular cataract (HP:0000523)1.74477002
152Median cleft lip (HP:0000161)1.74146640
153Renal cortical cysts (HP:0000803)1.73357537
154Enlarged penis (HP:0000040)1.73213229
155Cafe-au-lait spot (HP:0000957)1.72971552
156Aneurysm (HP:0002617)1.71980113
157Abnormality of renal excretion (HP:0011036)1.71738057
158Duplicated collecting system (HP:0000081)1.71514377
159Rhabdomyosarcoma (HP:0002859)1.71475111
160Ankle contracture (HP:0006466)1.71009176
161Prominent metopic ridge (HP:0005487)1.70478640
162Astigmatism (HP:0000483)1.70247415
163Epidermoid cyst (HP:0200040)1.69343072
164Hypobetalipoproteinemia (HP:0003563)1.69154327
165Optic nerve hypoplasia (HP:0000609)1.69073214
166Attenuation of retinal blood vessels (HP:0007843)1.68859097
167High pitched voice (HP:0001620)1.68821099
168Triphalangeal thumb (HP:0001199)1.68101037
169Aplasia/Hypoplasia of the sternum (HP:0006714)1.68043924
170Oculomotor apraxia (HP:0000657)1.68027972
171Aqueductal stenosis (HP:0002410)1.67292181
172Aplasia/Hypoplasia of the tongue (HP:0010295)1.67246073
173Pancreatic islet-cell hyperplasia (HP:0004510)1.66924663
174Atrioventricular block (HP:0001678)1.66697314
175Congenital stationary night blindness (HP:0007642)1.66660270
176Aplasia/Hypoplasia of the tibia (HP:0005772)1.66582829
177Abnormality of the labia majora (HP:0012881)1.65849840
178Hyperglycinemia (HP:0002154)1.64865259
179Spastic diplegia (HP:0001264)1.64806391
180Hypoglycemic seizures (HP:0002173)1.64284011
181Intrahepatic cholestasis (HP:0001406)1.63993251
182Abnormality of the septum pellucidum (HP:0007375)1.63470271
183Preaxial hand polydactyly (HP:0001177)1.63265399
184Abnormality of sulfur amino acid metabolism (HP:0004339)1.62961282
185Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.62584800
186Fatigue (HP:0012378)1.62367250
187Absent septum pellucidum (HP:0001331)1.61622706
188Increased purine levels (HP:0004368)1.61435310
189Hyperuricemia (HP:0002149)1.61435310
190Multiple enchondromatosis (HP:0005701)1.61094588
191Absent radius (HP:0003974)1.60675623
192Hypoglycemic coma (HP:0001325)1.60542236
193Complement deficiency (HP:0004431)1.59753685
194Subacute progressive viral hepatitis (HP:0006572)1.56750557
195Abnormal spermatogenesis (HP:0008669)1.56682319
196Abnormality of the common coagulation pathway (HP:0010990)1.56374022
197Stroke (HP:0001297)1.55737584
198Reticulocytosis (HP:0001923)1.55385176

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK24.57672131
2PDK34.30226499
3PDK44.30226499
4TRIB33.82843485
5CDK123.33874135
6PKN22.93669754
7TESK12.83421750
8MKNK22.73485621
9ZAK2.70337077
10WNK32.66711287
11BMPR1B2.65513118
12PDK22.51603371
13NEK22.51360359
14LATS12.49613047
15EIF2AK32.45113361
16ACVR1B2.43315283
17EEF2K2.41214224
18ICK2.20216405
19FRK2.11302096
20MKNK12.11136890
21TNIK2.09658167
22PRKD32.00647444
23TTN1.87728675
24EPHA21.85270726
25NUAK11.81366719
26TRIM281.76701068
27MAP3K101.73714363
28PLK31.70242178
29STK31.62572532
30RIPK11.58464489
31BCKDK1.53610097
32ERN11.52358268
33STK38L1.50730100
34BRD41.49358398
35PTK61.48591170
36TAOK11.48539567
37LATS21.43600835
38MAP2K21.43041870
39EIF2AK11.36717485
40STK381.36345708
41BUB11.36333143
42PAK41.31742874
43STK391.30697499
44PLK21.29579190
45TSSK61.26907272
46PNCK1.25922036
47MTOR1.25920686
48MAP3K41.24289525
49CASK1.23742728
50AKT31.20940353
51TTK1.18807606
52EPHB11.17164917
53MAP4K21.16029099
54SCYL21.14148048
55CDC71.13251647
56EPHA41.12538631
57MAP2K31.06678618
58GRK11.05491491
59PAK31.05185867
60NEK11.05131106
61MUSK1.04405859
62PTK2B1.03901383
63STK101.02786649
64SRPK11.02122411
65FGFR11.01351667
66INSRR0.99589928
67ATR0.99371899
68BRSK10.96572473
69MAPK130.96171075
70TLK10.95006121
71ERBB30.94916110
72CDK40.93837918
73DMPK0.93471365
74NTRK30.92154834
75CDK60.89999303
76PAK20.88357199
77CAMK1D0.87533592
78MAP3K30.87017961
79BMX0.86455719
80ALK0.86281806
81OXSR10.85300792
82PDGFRA0.84721647
83CAMK1G0.77870574
84TGFBR10.77291083
85ADRBK20.77080250
86NLK0.76834951
87MAP3K50.76790176
88MAP3K80.76138538
89PLK40.74608106
90DYRK1B0.74586725
91FGFR40.72427355
92MST40.70016592
93CHEK20.69626523
94SIK10.69621061
95WNK40.66911774
96PDGFRB0.65843260
97MAPK110.65807087
98KSR20.64957316
99MELK0.64603088
100PTK20.64583185
101MARK30.62168101
102PBK0.60935939
103CHEK10.60452033
104PDK10.59599798
105CDK10.59399619
106MAP4K10.59105889
107VRK10.58619007
108ZAP700.56660521
109CDK30.55268943
110CSNK1G10.55069438
111NEK60.53512485
112EIF2AK20.52681024
113MAP3K60.52462485
114TYRO30.51461658
115PIM10.50378496
116DDR20.50255486
117MAPKAPK30.49742029
118RET0.49450695
119PRKCE0.48917267
120PRKDC0.48098653
121MAP3K90.47967125
122LRRK20.47804028
123DYRK30.47637313
124JAK30.47627440
125PRKCI0.47541683
126PKN10.46518550
127MAP2K10.45919336
128PRKAA10.45672037
129PRKCG0.45235060
130RPS6KA40.44851056
131PDPK10.43351606
132RPS6KB20.43121872
133AURKB0.43106148
134WNK10.42290221
135GSK3B0.42280700
136PLK10.42072521
137CSK0.42014585
138CHUK0.41752444
139MST1R0.41295642
140PRKACB0.41117739
141PAK10.40912452
142FER0.40495524
143NEK90.40404102
144PHKG20.39672887
145PHKG10.39672887
146STK40.39661130
147CDK70.39100802
148PINK10.37279775
149CSNK1E0.35982960
150RPS6KA10.35698998
151FGFR20.35100930
152CAMK2A0.35025091
153ATM0.34922574
154MAP3K110.34872588
155MARK10.33899709
156CDK20.33767900
157BRSK20.33380139
158LMTK20.33013026
159PASK0.32366033
160WEE10.32238125
161MAPKAPK50.31107980
162CDK90.30476109
163CSNK1G20.29967694
164IRAK10.29501122
165ERBB40.28864466
166CSNK1D0.28637623
167STK110.28545650
168MAPK140.27952234
169PRKAA20.27363408
170CAMKK10.27170590
171DYRK1A0.26658321

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049752.99592898
2Non-homologous end-joining_Homo sapiens_hsa034502.83282935
3Olfactory transduction_Homo sapiens_hsa047402.75031200
4Fanconi anemia pathway_Homo sapiens_hsa034602.68464576
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.52666857
6Homologous recombination_Homo sapiens_hsa034402.50285751
7RNA degradation_Homo sapiens_hsa030182.34563049
8Vitamin B6 metabolism_Homo sapiens_hsa007502.23488129
9Ovarian steroidogenesis_Homo sapiens_hsa049132.22362461
10Selenocompound metabolism_Homo sapiens_hsa004502.16754386
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05894365
12Sulfur metabolism_Homo sapiens_hsa009202.03779111
13Mismatch repair_Homo sapiens_hsa034302.00495358
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.95781323
15Glycerolipid metabolism_Homo sapiens_hsa005611.85825413
16Arginine biosynthesis_Homo sapiens_hsa002201.84421489
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81709010
18Oocyte meiosis_Homo sapiens_hsa041141.80999543
19Nitrogen metabolism_Homo sapiens_hsa009101.73643655
20Biosynthesis of amino acids_Homo sapiens_hsa012301.70274330
21Insulin secretion_Homo sapiens_hsa049111.69087929
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68502480
23PPAR signaling pathway_Homo sapiens_hsa033201.65315754
24Circadian rhythm_Homo sapiens_hsa047101.64580321
25Pentose phosphate pathway_Homo sapiens_hsa000301.64564397
26Fatty acid degradation_Homo sapiens_hsa000711.64305578
27Propanoate metabolism_Homo sapiens_hsa006401.57719063
28Ether lipid metabolism_Homo sapiens_hsa005651.57543845
29Carbon metabolism_Homo sapiens_hsa012001.56880096
30Butanoate metabolism_Homo sapiens_hsa006501.55561387
31Pyruvate metabolism_Homo sapiens_hsa006201.52349490
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51849221
33DNA replication_Homo sapiens_hsa030301.51674846
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51265987
35Phototransduction_Homo sapiens_hsa047441.50784247
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.49172617
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43501697
38Taste transduction_Homo sapiens_hsa047421.40491904
39Fatty acid biosynthesis_Homo sapiens_hsa000611.39982961
40Protein export_Homo sapiens_hsa030601.37653074
41Protein digestion and absorption_Homo sapiens_hsa049741.31012243
42Glucagon signaling pathway_Homo sapiens_hsa049221.23464949
43Nicotine addiction_Homo sapiens_hsa050331.21830773
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21661965
45RNA transport_Homo sapiens_hsa030131.21516551
46Pancreatic secretion_Homo sapiens_hsa049721.20074982
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.20059925
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19171362
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.18340246
50Lysine degradation_Homo sapiens_hsa003101.17937814
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16260880
52Nucleotide excision repair_Homo sapiens_hsa034201.15852523
53Thyroid hormone synthesis_Homo sapiens_hsa049181.13245239
54mTOR signaling pathway_Homo sapiens_hsa041501.12811259
55Glutamatergic synapse_Homo sapiens_hsa047241.11285053
56Small cell lung cancer_Homo sapiens_hsa052221.10673584
57Cyanoamino acid metabolism_Homo sapiens_hsa004601.09886897
58Insulin resistance_Homo sapiens_hsa049311.09687794
59Base excision repair_Homo sapiens_hsa034101.08046908
60Circadian entrainment_Homo sapiens_hsa047131.07889130
61Morphine addiction_Homo sapiens_hsa050321.06917211
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06047880
63Central carbon metabolism in cancer_Homo sapiens_hsa052301.05801189
64Salivary secretion_Homo sapiens_hsa049701.04467771
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03938609
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03523556
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02592222
68Complement and coagulation cascades_Homo sapiens_hsa046101.01485331
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01313643
70RNA polymerase_Homo sapiens_hsa030201.01061511
71Fructose and mannose metabolism_Homo sapiens_hsa000511.00625312
72Linoleic acid metabolism_Homo sapiens_hsa005911.00188287
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99964183
74VEGF signaling pathway_Homo sapiens_hsa043700.97631401
75Dorso-ventral axis formation_Homo sapiens_hsa043200.97405092
76Caffeine metabolism_Homo sapiens_hsa002320.97133747
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.95426637
78Purine metabolism_Homo sapiens_hsa002300.94486454
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93688014
80GABAergic synapse_Homo sapiens_hsa047270.93609374
81Basal transcription factors_Homo sapiens_hsa030220.92712446
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92123547
83Viral myocarditis_Homo sapiens_hsa054160.90819299
84Collecting duct acid secretion_Homo sapiens_hsa049660.90599385
85Starch and sucrose metabolism_Homo sapiens_hsa005000.90418162
86Amphetamine addiction_Homo sapiens_hsa050310.89031943
87Hedgehog signaling pathway_Homo sapiens_hsa043400.88940554
88Bile secretion_Homo sapiens_hsa049760.88438014
89Adherens junction_Homo sapiens_hsa045200.87824153
90Fatty acid metabolism_Homo sapiens_hsa012120.87040744
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83418321
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.82131375
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82118583
94Chronic myeloid leukemia_Homo sapiens_hsa052200.81658667
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81348975
96Bladder cancer_Homo sapiens_hsa052190.81226743
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80849971
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.79788844
99AMPK signaling pathway_Homo sapiens_hsa041520.79303896
100Toxoplasmosis_Homo sapiens_hsa051450.78666196
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77105389
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.75938814
103Tryptophan metabolism_Homo sapiens_hsa003800.74229269
104Synaptic vesicle cycle_Homo sapiens_hsa047210.73889631
105Endometrial cancer_Homo sapiens_hsa052130.73809478
106One carbon pool by folate_Homo sapiens_hsa006700.73690866
107Gastric acid secretion_Homo sapiens_hsa049710.72613508
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72112056
109Cocaine addiction_Homo sapiens_hsa050300.71926891
110p53 signaling pathway_Homo sapiens_hsa041150.71602953
111Serotonergic synapse_Homo sapiens_hsa047260.71014639
112Sulfur relay system_Homo sapiens_hsa041220.70882675
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70738750
114Staphylococcus aureus infection_Homo sapiens_hsa051500.69941802
115Renin-angiotensin system_Homo sapiens_hsa046140.67437279
116Insulin signaling pathway_Homo sapiens_hsa049100.67255513
117Calcium signaling pathway_Homo sapiens_hsa040200.65699744
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.65580443
119mRNA surveillance pathway_Homo sapiens_hsa030150.65309263
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65224187
121Notch signaling pathway_Homo sapiens_hsa043300.64874568
122Fatty acid elongation_Homo sapiens_hsa000620.64634299
123Regulation of autophagy_Homo sapiens_hsa041400.64097679
124Melanogenesis_Homo sapiens_hsa049160.64068127
125Viral carcinogenesis_Homo sapiens_hsa052030.61639676
126Hippo signaling pathway_Homo sapiens_hsa043900.61417086
127Spliceosome_Homo sapiens_hsa030400.61019598
128HIF-1 signaling pathway_Homo sapiens_hsa040660.60258464
129Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59957760
130Pancreatic cancer_Homo sapiens_hsa052120.59898644
131Legionellosis_Homo sapiens_hsa051340.59408932
132Steroid biosynthesis_Homo sapiens_hsa001000.58738972
133Amoebiasis_Homo sapiens_hsa051460.57259348
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57068699
135Focal adhesion_Homo sapiens_hsa045100.57026969
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55662155
137Cell cycle_Homo sapiens_hsa041100.55148397
138beta-Alanine metabolism_Homo sapiens_hsa004100.54094901
139TGF-beta signaling pathway_Homo sapiens_hsa043500.53648793
140Apoptosis_Homo sapiens_hsa042100.53610892
141Non-small cell lung cancer_Homo sapiens_hsa052230.53459010
142Arginine and proline metabolism_Homo sapiens_hsa003300.53295098
143Antigen processing and presentation_Homo sapiens_hsa046120.53179768
144Oxytocin signaling pathway_Homo sapiens_hsa049210.53158981
145Galactose metabolism_Homo sapiens_hsa000520.52922031
146Arachidonic acid metabolism_Homo sapiens_hsa005900.52599800
147Folate biosynthesis_Homo sapiens_hsa007900.52206345
148Proteoglycans in cancer_Homo sapiens_hsa052050.49483460
149Acute myeloid leukemia_Homo sapiens_hsa052210.49199969
150Vitamin digestion and absorption_Homo sapiens_hsa049770.48144472
151Influenza A_Homo sapiens_hsa051640.47244033
152HTLV-I infection_Homo sapiens_hsa051660.46985242
153FoxO signaling pathway_Homo sapiens_hsa040680.46012642
154Glutathione metabolism_Homo sapiens_hsa004800.45694492
155Maturity onset diabetes of the young_Homo sapiens_hsa049500.45599048
156cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45515208
157Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45338621
158Gap junction_Homo sapiens_hsa045400.44689708
159Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44475875
160Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43922917
161ABC transporters_Homo sapiens_hsa020100.43842977
162Tight junction_Homo sapiens_hsa045300.43009295
163Renal cell carcinoma_Homo sapiens_hsa052110.42898270
164Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42579180
165cAMP signaling pathway_Homo sapiens_hsa040240.42438017
166Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41644482
167Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41429462
168Cholinergic synapse_Homo sapiens_hsa047250.41397015
169Wnt signaling pathway_Homo sapiens_hsa043100.39610413
170Inositol phosphate metabolism_Homo sapiens_hsa005620.39319048
171Dopaminergic synapse_Homo sapiens_hsa047280.38323271
172Pyrimidine metabolism_Homo sapiens_hsa002400.37867055

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